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1 ISL1) in the secondary heart field (SHF) are normoxic.
2 al hemorrhage (49%) of whom 1,084 (38%) were normoxic, 1,316 (46%) were hypoxic, and 450 (16%) were h
3 +/-SD) years old were randomly assigned to a normoxic (21% O2) and hypoxic (10% O2) trial with measur
5 tilated TBI patients, of whom 403 (33%) were normoxic, 553 (46%) were hypoxic and 256 (21%) were hype
7 f oxygen supplementation was equivalent to a normoxic 94% or higher target for infants admitted to ho
8 line rats are hyperproliferative and display normoxic activation of hypoxia-inducible factor-1alpha (
9 AH (P(50) = 16 +/- 1 mmHg), had them perform normoxic and acute hypoxic (15% inspired oxygen) maximal
10 lmonary and renal mitochondria isolated from normoxic and chronically hypoxic rats were infused into
12 vascular density of the labrynthine zone in normoxic and hypoxic (Hx) conditions, and mean vascular
13 The same measurements were repeated under normoxic and hypoxic (normobaric (NH) and hypobaric (HH)
14 cells and mediate the communication between normoxic and hypoxic areas of tumors to facilitate cance
17 ivity was induced by serum depletion both in normoxic and hypoxic cells and that activation of SREBP
19 hibited this hypertrophy response under both normoxic and hypoxic conditions (26% lower than control
20 sion of fur protected Salmonella grown under normoxic and hypoxic conditions against the bacteriostat
21 s, and stabilized HIF-1alpha protein in both normoxic and hypoxic conditions by blocking its proteaso
22 d delivery strategy was evaluated under both normoxic and hypoxic conditions in normal tissues as wel
24 min addition to these MCT-disrupted cells in normoxic and hypoxic conditions induced a rapid drop in
26 umor cells with low light fluence under both normoxic and hypoxic conditions, after activation by int
27 sformed human mammary epithelial cells under normoxic and hypoxic conditions, and applying in silico
28 formability, increasing sRBC occlusion under normoxic and hypoxic conditions, and increasing sRBC adh
29 ng, lowers HIF-1alpha protein levels in both normoxic and hypoxic conditions, consistent with a role
31 xic effects after 72 h of incubation in both normoxic and hypoxic conditions, unlike sulfonamide CA i
32 verexpressing CA IX and XII was tested under normoxic and hypoxic conditions, using 2D and 3D in vitr
44 ons achievable by dietary intervention under normoxic and hypoxic conditions; a moderate dose of nitr
45 ystem is validated by testing the effects of normoxic and hypoxic culture conditions on healthy and t
47 lastoma), we quantified miR-124 abundance in normoxic and hypoxic regions in glioblastoma patient tis
48 ibrary from 4(th) instar larvae subjected to normoxic and hypoxic treatments (respectively), and perf
52 ed ventilatory responses to acute hypoxia in normoxic animals without altering the output of the CB (
53 The expression pattern corresponded to the normoxic animals, as far as verifiable due to the existi
54 he animals were mechanically ventilated with normoxic artificial air with or without 2.5% methane.
55 he 3rd week of hypoxia regressed back toward normoxic baseline as the duration of re-oxygenation cont
56 mory (EM) CD4(+) T cells recirculate between normoxic blood and hypoxic tissues to screen for cognate
57 rat hearts (n = 5/group) were perfused with normoxic buffer for 30 min and then hypoxic buffer for 4
58 d acclimatization using four groups of rats: normoxic, caffeine-treated normoxic, chronically hypoxic
59 thetic pathway activation, favor hypoxic and normoxic cancer cell survival and correlate with pancrea
63 in hypoxic cells, whereas STAT3 knockdown in normoxic cells also reduces cell proliferation, motility
64 alised to distinct cytoplasmic aggregates in normoxic cells and underwent redistribution to the leadi
68 cells, and we propose that, via this route, normoxic cells supply hypoxic neighbors with acid-neutra
69 ubicin-induced accumulation of HIF-1alpha in normoxic cells was caused by increased expression and ac
71 f fluorescent CA IX signal in hypoxic versus normoxic cells, which could be blocked by 60%-70% with u
74 r groups of rats: normoxic, caffeine-treated normoxic, chronically hypoxic (12% O(2), 15 days), and c
76 resence of functional VHL-wt protein under a normoxic condition, which might then result in increasin
78 proteins, BAX and BIM, down-regulated under normoxic condition; (2) beta1 Integrin/FAK signaling pat
79 ion of NF-kappaB, S6, c-Myc, and c-Jun under normoxic condition; (2) blocked myeloma cell migration a
82 egradation, stabilized HIF-1 activity during normoxic conditions and elevated miR-429 levels, demonst
83 the alpha subunit of HIF1 (HIF1alpha) under normoxic conditions and enhances HIF1alpha accumulation
84 n results in myocardial ischemia under basal normoxic conditions and in acute cardiac decompensation
85 ly within cardiac myocyte mitochondria under normoxic conditions and is consistently associated with
86 ominant HIF-hydroxylase in neutrophils under normoxic conditions and link intrinsic regulation of gly
87 rexpressing cancer cells stabilize HIF under normoxic conditions and require HIF-1 for ERBB2-mediated
88 ive oxygen species-mediated phototoxicity in normoxic conditions and small molecule uncaging in hypox
89 ence and respond to CD44-ICD induction under normoxic conditions and therefore independent of Hif1alp
90 rom GBM cells grown at hypoxic compared with normoxic conditions are potent inducers of angiogenesis
91 erfused with 26 mm [1,6-(13)C2]glucose under normoxic conditions at 37 degrees C and monitored by (13
92 HIF-1 activity is usually suppressed under normoxic conditions because of rapid oxygen-dependent de
93 axis that is dispensable for survival under normoxic conditions but is critical for non-replicating
94 n factor HIF-1alpha, which is degraded under normoxic conditions by HIF-prolyl hydroxylase (HIF-PHD).
95 RNA and protein, the reversal of which under normoxic conditions decreased T-cell-suppressive effects
96 ntra-arterially with 3.4 mug.g(-1) FLX under normoxic conditions displayed a transient tachycardia an
97 e slowed in metastatic melanomas, even under normoxic conditions due to the persistence of a high nuc
99 itrogen in the presence of acetate and under normoxic conditions is accompanied by a marked increase
100 egradation by prolyl hydroxylase (PHD) under normoxic conditions is emerging as a promising option in
101 ic inhibition of complex II by atpenin A5 in normoxic conditions mimics hypoxia and induces hypoxic t
103 tag), we found that exposure to NO2(-) under normoxic conditions or exposure to ischemia alone result
105 eriods of hypoxia and recover development if normoxic conditions resume, an ability rarely found in m
106 exosomes derived from hypoxic compared with normoxic conditions showed increased autocrine, promigra
107 tion of HIF1A transcriptional activity under normoxic conditions through regulation of succinate dehy
108 vate anaerobic genes but are destabilized in normoxic conditions through the action of oxygen-sensing
109 , human RBCs constitutively produce NO under normoxic conditions via an active eNOS isoform, the acti
111 le, even under deviations from physiological normoxic conditions, and show minimal interference from
112 on hydrogen cyanamide (HC) application under normoxic conditions, and their levels peak at deepest do
113 ncreased HIF-2alpha protein expression under normoxic conditions, and up-regulated HIF-dependent gene
117 e indistinguishable from control cells under normoxic conditions, but are unable to survive and proli
118 ly more able to exploit food resources under normoxic conditions, but at the cost of being more sensi
119 marginally important to generate LG3 during normoxic conditions, cathepsin B activity was found to b
120 yl-hydroxylated by EglN family members under normoxic conditions, causing its rapid degradation.
121 end to utilize aerobic glycolysis even under normoxic conditions, commonly called the "Warburg effect
122 eactive oxygen species in these cells and in normoxic conditions, decreased the mitochondrial oxygen
128 essed under hypoxia, is down-regulated under normoxic conditions, leading to an increase in dephospho
130 not cause unfolded protein response and, in normoxic conditions, only marginally affects proinflamma
132 ibitor PLX5622, while having no effect under normoxic conditions, profoundly increased vascular leak
134 ctivity and trigger a hypoxic response under normoxic conditions, such as iron chelators and inhibito
135 or of this process, but its activation under normoxic conditions, termed pseudohypoxia, is not well d
136 ogenesis of renal cell carcinoma (RCC) under normoxic conditions, through the loss of the Von Hippel-
137 hance MDSC-mediated T-cell suppression under normoxic conditions, while targeting hypoxia-induced miR
138 (+) and the accumulation of HIF-1alpha under normoxic conditions, with parallels to Warburg reprogram
139 pression induced CD24 mRNA and protein under normoxic conditions, with this effect traced to a recrui
174 metabolism were compared under hyperglycemic normoxic conditions; 51% of the energy came from oxidati
175 TSM provided significant gains in hypoxic-to-normoxic contrast (14:1 for (64)Cu-2,3-butanedione bis(t
176 hold, only (64)Cu-CTS delivered a hypoxic-to-normoxic contrast of 3:1, and it therefore warrants in v
177 e pre-BotC of CIH rats, when compared to the normoxic control and hypoxic group with daily acute inte
181 stress (4-hydroxynonenal, 141.1 +/- 17.6% of normoxic control), reduced superoxide dismutase (60.7 +/
182 immunohistochemistry in four groups of ewes: normoxic control, normoxia + ketamine, hypoxic control a
183 er and lesser, respectively, relative to the normoxic control, thus leading to an increased T/E2 rati
193 lation whenever it was increased relative to normoxic controls; i.e. acute hypoxia in CON and CSH, an
194 inct functional areas (the rim, hypoxic, and normoxic cores) were clearly discernible based on spatia
196 We show that in Saccharomyces cerevisiae, normoxic COX activity measured in the presence of ATP is
207 enhanced induction by hypoxic compared with normoxic exosomes of tumor vascularization, pericyte ves
210 as wash-in MR imaging during inhalation of a normoxic fluorinated gas mixture (perfluoropropane) and
213 ed function in neonatal hypoxic and neonatal normoxic groups compared with saline-treated controls.
215 /tissue treated with Ndufs2 siRNA) decreased normoxic H(2)O(2), prevented hypoxic increases in [Ca(2+
217 lind randomized manner, while breathing: (i) normoxic helium-oxygen (HEL) to reduce the work of breat
218 rvival of class I nuclei are compatible with normoxic hESC derivation, and that chemical supplementat
219 r HIF1A in lung protection during ALI, where normoxic HIF1A stabilization and HIF-dependent control o
220 f succinate dehydrogenase (SDH) in mediating normoxic HIF1A stabilization, concomitant increases in g
223 ~43 mmHg, P(a) CO(2) ~33 mmHg, pH ~7.39), or normoxic hypercapnia (S(a) O(2) ~98%, P(a) O(2) ~105 mmH
224 In wakefulness, the ventilatory response to normoxic hypercapnia is higher in young SHRs (mean +/- S
225 e authors administered a series of identical normoxic hyperpolarized gas breaths to the subject; afte
227 mitochondria in vitro and in vivo, promoting normoxic hypoxia inducible factor-1alpha activation and
229 by retinal pigmented epithelial cells under normoxic, hypoxic, and lutein-pretreated conditions in a
231 ypoxia (three, 5 min hypoxic episodes, 5 min normoxic intervals) induced phrenic long-term facilitati
232 of dual-specificity phosphatase 16 increased normoxic levels of IL-6 and IL-1beta and reduced the hyp
235 modulates O(2) delivery to hypoxic (FME) and normoxic (LOX) human melanoma xenografts in a murine win
237 d higher amounts of mature IL-1beta than did normoxic macrophages after treatment with crystalline ch
240 that the NK cell immune synapse formed with normoxic melanoma cells is more stable and contains a hi
241 metabolism following hypoxia due to abnormal normoxic metabolism, which was associated with a functio
244 nd increased uterine artery contractility in normoxic mice, providing evidence that physiological lev
249 ) medium (+/- fetal bovine serum, FBS) under normoxic (N, p(O(2)) = 20%) or hypoxic (H, p(O(2)) < 2%)
252 ed cardiac function; however, mechanisms for normoxic neonatal CPC exosomes improved function indepen
254 capable of increasing circulating Epo under normoxic, nonanemic conditions in a previously unrecogni
256 ts were divided into 3 groups (n = 5/group): normoxic (Nx), HI and HI pre-treated with Src kinase inh
260 sies and on A549 LUAD cell lines cultured in normoxic or hypoxic conditions, we identified a subset o
264 (64)Cu][Cu(ATSM)] pharmacokinetics in either normoxic or hypoxic hearts, beyond decreasing cardiac ox
265 xation to acetylcholine in aged offspring of normoxic or hypoxic pregnancy but not in young offspring
266 g (4 mo) and aged (15 mo) adult offspring of normoxic or hypoxic pregnancy with or without maternal a
267 aused phenylephrine pre-constricted UtA from normoxic or hypoxic pregnant mice to dilate and this dil
269 del simulating high-density encapsulation to normoxic or ischemic culture for 12 hours, after which v
272 osphatidylglycerol species were increased in normoxic pellets, whereas phosphatidylinositol species w
275 lphide-synthesis blockers on HPV and also on normoxic pulmonary vasoconstriction (NPV) stimulated by
280 ies in transformed cell lines suggested that normoxic stabilization of HIF-1alpha explains the persis
281 ns in von Hippel-Lindau (VHL) and subsequent normoxic stabilization of hypoxia-inducible factor (HIF)
282 nt metabolic alterations are associated with normoxic stabilization of hypoxia-inducible factors (HIF
284 e ATP-mediated regulation of COX through the normoxic subunit Cox5a, homologue of human COX4i1, in a
286 forest fish to four DO levels, ranging from normoxic to hypoxic (8.7, 6.0, 4.1, and 2.2 mg O(2) /L).
289 tion, doxorubicin enhanced VEGF secretion by normoxic tumor cells and stimulated tumor angiogenesis.
291 nosis association was particularly strong in normoxic tumor samples and was linked to an increased ri
294 oxia and compared the results with those for normoxic turtles (25 degrees C) and mouse hearts exposed
297 ha deletion had no effect on the increase in normoxic ventilation with acclimatization to CH, indicat
298 that in systems with MeHg production in the normoxic water column eutrophication can increase phytop
299 tic Sea MeHgT budget, we inferred an average normoxic water column Hg(II) methylation rate constant o
300 hypoxia was not significantly different from normoxic WT mice and much lower than the RVSP values see