ライフサイエンスコーパス: norovirus

1 ant mediator of host defenses against murine norovirus.

2 these issues for hepatitis C virus (HCV) and norovirus.

3 immunoconverted to either GI (2) or GII (8) norovirus.

4 were associated with C. difficile and 1 with norovirus.

5 ric norovirus AGE cases were caused by GII.4 norovirus.

6 tors, have increased susceptibility to GII.4 noroviruses.

7 are a surrogate for neutralization in human noroviruses.

8 tralization activity against GII.4 and GII.6 noroviruses.

9 % vs 1.5%; p<0.01 for both) and outpatients (norovirus: 10.7%; C. difficile: 10.5%).

10 ses than controls (prevalence difference for norovirus: -11% [95% confidence interval [CI], -5 to -17

11 >=65 years old (AGE: 459; C. difficile: 91; norovirus: 26).

12 g outpatients (AGE: 2715; C. difficile: 285; norovirus: 291) and inpatients >=65 years old (AGE: 459;

13 dyl series of transition state inhibitors of norovirus 3CL protease, an enzyme essential for viral re

14 mucosal and systemic immune response against norovirus, 43 long-term care facilities were enrolled pr

15 es vs controls: C. difficile, 18.8% vs 8.4%; norovirus, 5.1% vs 1.5%; p<0.01 for both) and outpatient

16 Peak sporadic norovirus activity was often contemporaneous with outbre

17 outpatient and community-acquired inpatient norovirus AGE at 4 Veterans Affairs Medical Centers (VAM

18 Approximately half of sporadic pediatric norovirus AGE cases were caused by GII.4 norovirus.

19 of an in vitro cultivation system for human noroviruses allows the measurement of neutralizing antib

20 ent vomiting is the major source of airborne norovirus and imply a connection between airborne norovi

21 nanoconjugates has applied for detection of norovirus and influenza virus, respectively to confirm t

22 irus and imply a connection between airborne norovirus and outbreaks.

23 y immunodeficiency to protect against murine norovirus and rotavirus infections.

24 phage, a recognized surrogate for pathogenic norovirus and rotavirus.

25 o improve receptor affinity.IMPORTANCE Mouse norovirus and several other members of the Caliciviridae

26 nt antigens of genogroup I (GI) and II (GII) noroviruses and incubated with saliva.

27 cimens were tested by RT-qPCR for GI and GII noroviruses and subsequently genotyped by sequencing a p

28 ar bases behind the interplays between human noroviruses and their host glycan ligands, as well as th

29 requested diagnostic testing were tested for norovirus, and positive samples were genotyped.

30 ical for protection against influenza virus, norovirus, and reovirus.

31 viral pathogens, including influenza virus, norovirus, and rotavirus.

32 Results for Shigella spp, norovirus, and sapovirus suggested they had a stronger a

33 gastroenteritis and the presence of airborne norovirus, and to investigate the size of norovirus-carr

34 Our data are a resource for those studying noroviruses, and we provide a robust approach to identif

35 testinal PCR panel followed by genotyping of norovirus- and rotavirus-positive samples.

36 Abundant norovirus antigen and RNA are detected throughout the sm

37 ssfully generated T cells targeting multiple norovirus antigens with a mean 4.2 +/- 0.5-fold expansio

38 or conducting future birth cohort studies on norovirus are discussed.

39 Noroviruses are a leading cause of acute gastroenteritis

40 Noroviruses are a leading cause of foodborne illnesses w

41 Human noroviruses are a major cause of diarrheal illness, but

42 Globally, noroviruses are among the foremost causes of acute diarr

43 Phylogenetically, noroviruses are divided into seven genogroups, with each

44 Noroviruses are known to bind to histo-blood group antig

45 Noroviruses are nonenveloped, icosahedral viruses of glo

46 Human noroviruses are the leading cause of severe childhood di

47 Noroviruses are the main causative agents of acute viral

48 Noroviruses are the major cause of viral gastroenteritis

49 Noroviruses are the most common cause of epidemic and en

50 Human noroviruses are the most common viral agents of acute ga

51 As noroviruses are transmitted through the fecal-oral route

52 igh-resolution solution structures of murine norovirus as a model for human viruses.

53 orovirus infection and up to 70% experienced norovirus-associated diarrhea, most often affecting chil

54 genomes were generated from new episodes of norovirus at a pediatric tertiary referral hospital over

55 n recommends that food workers infected with norovirus be excluded from the workplace while symptomat

56 In particular, norovirus behavior through unit processes may be over- o

57 se data provide a resource for understanding norovirus biology and demonstrate a robust methodology f

58 Despite its prevalence, our understanding of norovirus biology is limited due to the difficulty in gr

59 e two participants who immunoconverted to GI norovirus both swallowed water during swimming (p = 0.08

60 he majority of outbreaks are caused by GII.4 noroviruses, but data supporting whether this is true fo

61 n trans These findings offer a model for how norovirus can regulate the timing of substrate cleavage

62 by antibodies mapping to the P domain of the norovirus capsid protein.

63 ne norovirus, and to investigate the size of norovirus-carrying particles.

64 June 2016, there were 755 pediatric sporadic norovirus cases and 45 reported outbreaks.

65 ypic distribution between sporadic pediatric norovirus cases and reported norovirus outbreaks in midd

66 led the number and proportion of symptomatic norovirus cases averted annually in the US population (u

67 ronologically overlapping, hospital-acquired norovirus cases were partitioned into 3 discrete transmi

68 Murine noroviruses cause diarrhea in interferon-deficient adult

69 Herein we report that a murine norovirus causes self-resolving diarrhea in the absence

70 or binding cellular ligands.IMPORTANCE Human norovirus causes ~20% of all acute gastroenteritis and ~

71 icant importance as it allows ultrasensitive norovirus detection rapidly within minutes, while also o

72 Routine norovirus diagnosis requires stool collection.

73 The greatest risk of severe norovirus disease (Vesikari score >=11) was associated w

74 ce, thus mirroring the key features of human norovirus disease and representing a norovirus small ani

75 The burden of norovirus disease in low-income settings is poorly under

76 s in US Veterans, highlighting the burden of norovirus disease in this adult population.

77 in the translatability of findings to human norovirus disease.

78 Norovirus enteritis can cause intractable diarrhea in so

79 orally administered human immunoglobulin for norovirus enteritis, and it appeared to be an effective

80 Norovirus evolution and diversity may be driven by local

81 re stratified by inflammation resulting from norovirus exposure.

82 micronutrient biomarkers from 0 to 35 d post-norovirus exposure.

83 vitamin B-12, and folate from 0 to 35 d post-norovirus exposure.

84 i) strains from case stool specimens matched norovirus found in frozen raspberries imported from Chin

85 August 2016, we investigated an outbreak of norovirus gastroenteritis in Minnesota that was linked t

86 In the United States, surveillance of norovirus gastroenteritis is largely restricted to outbr

87 s spanning the entire coding sequence of the norovirus genome.

88 genomic next-generation sequencing (mNGS) of norovirus genomes demonstrated that 10 chronologically o

89 Norovirus genomes were generated from new episodes of no

90 livary norovirus genotype-specific IgG using norovirus genotype from stool as reference.

91 rabbit hemorrhagic disease virus, and human norovirus genotype II.10) revealed a "floating" P domain

92 group 2 type 4 (GII.4) has been the dominant norovirus genotype worldwide since its emergence in the

93 ection status based on fold rise of salivary norovirus genotype-specific IgG using norovirus genotype

94 immunoglobulin G (IgG) responses to 5 common norovirus genotypes (GI.1, GII.2, GII.4, GII.6, and GII.

95 also protection due to prior infections for norovirus GII (cHR against diarrhea, 0.67; 95% CI, 0.49-

96 1, Shigella/enteroinvasive Escherichia coli, norovirus GII, sapovirus, and Cryptosporidium species.

97 Norovirus GII.17[P17] (GII.17 Kawasaki) strains from cas

98 stool specimens, 6% tested were positive for norovirus; GII.4 viruses (GII.4 New Orleans [17%] and GI

99 elucidated the molecular bases of the human norovirus-glycan interactions of this special genetic li

100 followed longitudinally; all were exposed to norovirus, half were infected.

101 Acute gastroenteritis caused by noroviruses has a major impact on public health worldwid

102 rall, we estimated that 6.0 million cases of norovirus have already been avoided annually under the r

103 However, noroviruses have recently been found in aerosols and air

104 Within a norovirus human challenge study, we aimed to model the i

105 use of the lack of a simple and robust human norovirus (HuNoV) cell culture system surrogate, caliciv

106 of human restricted pathogens such as human norovirus (HuNoV) have defied interrogation because they

107 Human norovirus (HuNoV) is a leading cause of acute gastroente

108 removal and inactivation of infectious human norovirus (HuNoV) is a major focus in water purification

109 A viruses, such as the GII.4 strain of human norovirus (HuNoV), and their vaccines elicit complex ser

110 Human noroviruses (HuNoV) are the leading cause of gastroenter

111 Human noroviruses (HuNoVs) are the leading cause of viral gast

112 Human noroviruses (huNoVs) recognize histo-blood group antigen

113 y support the observed interactions of human noroviruses (huNoVs) with histo-blood group antigens (HB

114 Human noroviruses (huNoVs), which cause epidemic acute gastroe

115 defined as at least 4-fold increase in anti-norovirus IgG antibody response from S1 to S2 and a 3-fo

116 No vaccine is currently available to prevent norovirus illness or infection.

117 , yet there are many unanswered questions on norovirus immunity, particularly following natural infec

118 extensive onward nosocomial transmission of norovirus in a pediatric hospital with a high proportion

119 enate, supporting the potential of detecting norovirus in complex matrices.

120 Given the high burden of norovirus in most communities, it can be difficult to di

121 Here, we investigate the cellular tropism of norovirus in specimens from four immunocompromised patie

122 ew data are available on immune responses to norovirus in the elderly.

123 -lambda) determine the persistence of murine norovirus in the gut(2,3).

124 quantify the clinical and economic burden of norovirus in the United States.

125 outpatient and inpatient community-acquired norovirus in US Veterans, highlighting the burden of nor

126 mited due to the difficulty in growing human norovirus in vitro and a lack of an animal model.

127 coli, Vibrio cholerae, Campylobacter jejuni, norovirus) in cohorts from Haiti, Kenya, and Tanzania.

128 outpatient and inpatient community-acquired norovirus incidence rates in the first and third years o

129 clusion, gastroenteritis outbreaks caused by noroviruses increased rapidly in the last years and thes

130 Norovirus-infected subjects had median (IQR) peak concen

131 p to 90% of children experienced atleast one norovirus infection and up to 70% experienced norovirus-

132 nfectious challenge model in healthy adults, norovirus infection elicited a time-limited inflammatory

133 cteristics analysis correctly assigned prior norovirus infection in 23 (92%) of 25 participants.

134 Chronic norovirus infection in immunocompromised patients can be

135 o perform a detailed investigation of murine norovirus infection in microbially deplete mice, reveali

136 underlying bacteria-dependent inhibition of norovirus infection in the proximal gut involves bile ac

137 rom immunosuppressed patients with long-term norovirus infection indicates that initial virus in vivo

138 n on mucosal and systemic immune response to norovirus infection is derived from human challenge stud

139 y, the regional effects of the microbiota on norovirus infection may result from distinct regional ex

140 on of these results, the virulence of murine norovirus infection was unaffected by antibiotic treatme

141 rains isolated from a patient with long-term norovirus infection were characterized.

142 s the role of tuft cells in type 2 immunity, norovirus infection, and thymocyte development.

143 esent a novel treatment approach for chronic norovirus infection.

144 valuated genotypes compared to PCR-diagnosed norovirus infection.

145 al enteroids were shown to be permissive for norovirus infection.

146 th polymerase chain reaction (PCR)-diagnosed norovirus infections (n = 175) and controls (n = 32).

147 ed a multiplex salivary immunoassay to study norovirus infections among 483 visitors to a Lake Michig

148 non-invasive salivary immunoassay to detect norovirus infections and an efficient approach to study

149 The salivary assay detected recent norovirus infections and correctly assigned the infectin

150 Norovirus infections are a major cause of acute viral ga

151 Most (n = 118; 85%) norovirus infections belonged to genogroup II (GII).

152 ure review on birth cohort studies assessing norovirus infections in children from birth to early chi

153 peutics for the treatment and prophylaxis of norovirus infections underscores the need for the develo

154 cteria stimulate acute and persistent murine norovirus infections(2-4).

155 peatedly performed close to 26 patients with norovirus infections.

156 Norovirus is a leading cause of acute gastroenteritis wo

157 Norovirus is a leading cause of epidemic acute gastroent

158 Norovirus is a leading cause of worldwide and nosocomial

159 Norovirus is an important cause of epidemic acute gastro

160 e effectiveness of disinfection processes on norovirus is largely unknown owing to the lack of a read

161 entifying new antiviral molecules.IMPORTANCE Norovirus is one of the leading causes of food-borne ill

162 Norovirus is one of the most common causes of gastroente

163 Human norovirus is the leading cause of acute gastroenteritis

164 Norovirus is the leading cause of acute gastroenteritis

165 Human norovirus is the leading cause of gastroenteritis worldw

166 target to identify new antiviral agents for norovirus is the viral polymerase, which has a pivotal r

167 Herein, the multivalent interaction of norovirus-like particles (noroVLPs) with H or B type 1 g

168 headlines, it is unclear how much attention norovirus may receive otherwise.

169 Murine norovirus (MNoV) infects a low percentage of enteric tuf

170 Murine norovirus (MNoV) is a model norovirus system because MNo

171 identify host genes that can inhibit murine norovirus (MNoV) replication in human cells.

172 s study describes the inactivation of murine norovirus (MNV) by Fe(VI) in phosphate buffer (PB) and s

173 s study, the inactivation kinetics of murine norovirus (MNV) by PFA, in phosphate buffer and municipa

174 Recent studies on the closely related murine norovirus (MNV) have identified CD300LF as an indispensa

175 w that both IFN-gamma stimulation and murine norovirus (MNV) infection induce GBP2 expression in muri

176 cently demonstrated that infection by murine norovirus (MNV) reverses intestinal abnormalities follow

177 iruses/mL) detection of the infective murine norovirus (MNV), a readily cultivable surrogate for NoV.

178 l members of the Caliciviridae family (mouse norovirus [MNV], rabbit hemorrhagic disease virus, and h

179 eropathogenic Escherichia coli (n = 14, 8%), norovirus (n = 14, 8%), and Yersinia enterocolitica (n =

180 nteropathogenic Escherichia coli (n=14, 8%), norovirus (n=14, 8%), and Yersinia enterocolitica (n=7,

181 We further demonstrate the robustness of the norovirus NanoZyme aptasensor by testing its performance

182 ested their suitability as a system to study norovirus neutralization.

183 and should be considered when investigating norovirus nosocomial transmission.

184 ion rule (ICR) and to a literature review of norovirus (NoV) densities in ambient surface waters.

185 Norovirus (NoV) infections are a leading cause of gastro

186 Large norovirus (NoV) outbreaks are explosive in nature and va

187 Human norovirus (NoV) remains the most common cause of viral g

188 Noroviruses (NoVs) are a leading cause of gastroenteriti

189 Human noroviruses (NoVs) are the main cause of epidemic and sp

190 ive antivirals against NoVs.IMPORTANCE Human noroviruses (NoVs) cause sporadic and epidemic gastroent

191 s, Aichi virus 1 (AiV-1), enteroviruses, and noroviruses of genogroups I, II, and IV] were tested by

192 thout glycan ligands of three representative noroviruses of the GII.17/13/21 genetic lineage, we eluc

193 We present solid evidence on how noroviruses of this genetic lineage evolved via differen

194 ategy offers the most sensitive detection of norovirus or a norovirus surrogate achieved to date usin

195 e prevalence of pathogenic Escherichia coli, norovirus, or Giardia genes in the domestic environment

196 urden of enteroaggregative Escherichia coli, norovirus, or Giardia.

197 ime metagenomic sequencing during an ongoing norovirus outbreak associated with a retrospective cohor

198 To our knowledge, this is the first norovirus outbreak due to commercially distributed froze

199 ed a systematic review for studies reporting norovirus outbreak or sporadic case genotypes and merged

200 ctures of GII.4, GII.2, GI.7, and GI.1 human norovirus outbreak strain virus-like particles (VLPs).

201 odies and remained elevated 3 months after a norovirus outbreak.

202 estigators should thoroughly investigate all norovirus outbreaks (including stool testing and genotyp

203 Norovirus outbreaks are associated with very significant

204 To detect norovirus outbreaks associated with commercially distrib

205 Severe outcomes more frequently occurred in norovirus outbreaks caused by GII.4 and those in healthc

206 Norovirus outbreaks due to commercially distributed food

207 e Network in a single county, while reported norovirus outbreaks from 7 middle Tennessee counties wer

208 e Network in a single county, while reported norovirus outbreaks from seven middle Tennessee counties

209 Norovirus outbreaks in hospital settings are a common ch

210 radic pediatric norovirus cases and reported norovirus outbreaks in middle Tennessee.

211 Most norovirus outbreaks occurred in primary schools and 94 o

212 Six nursing home norovirus outbreaks occurring in South Carolina, U.S. fr

213 Although norovirus outbreaks periodically make headlines, it is u

214 009-2016 were linked to laboratory-confirmed norovirus outbreaks reported to CaliciNet.

215 Acute norovirus outbreaks reported to the National Outbreak Re

216 A total of 3747 norovirus outbreaks were matched from NORS and CaliciNet

217 From January 2015 to December 2018, 213 norovirus outbreaks with 3,951 patients were reported in

218 strains accounted for 6 (5.5%) and 9 (8.3%) norovirus outbreaks, respectively.

219 GII.4 strains have been responsible for most norovirus outbreaks, the assembled virus shell structure

220 norovirus transmission in U.S. nursing home norovirus outbreaks.

221 e roles that specific cell types play during norovirus pathogenesis.

222 arting from the scaffold of a novel class of norovirus polymerase inhibitors recently discovered in o

223 ections from an unknown source; and 43% were norovirus positive on admission.

224 indings are consistent with the detection of norovirus-positive EECs in the other three immunocomprom

225 responsible for at least 178 (83.6%) of 213 norovirus-positive outbreaks with a peak in 2017 and 201

226 Overall, 636 (22%) samples were norovirus-positive, of which 567 (89%) were GII.

227 this individual-level trait may drive GII.4 norovirus predominance at the human population level.

228 Incidence was calculated by multiplying norovirus prevalence among tested specimens by AGE-coded

229 urden could help determine how to prioritize norovirus prevention and control.

230 we characterized how precursor forms of the norovirus protease accumulate during infection.

231 Because the norovirus protease represents a key target in antiviral

232 The concentrations of airborne norovirus ranged from 5-215 copies/m3, and detectable am

233 Study-level GII.4 proportion among all noroviruses ranged from 0% to 100%.

234 ese mice display defective control of murine norovirus, reovirus, and influenza virus and therefore g

235 scaffold for norovirus, which inhibits human norovirus replication at low-micromolar concentrations.

236 o identify improved agents effective against norovirus replication in cell-based assays.

237 We found 49 genes that could block murine norovirus replication in human cells.

238 A vital process for norovirus replication is the processing of the nonstruct

239 To identify host genes that can restrict norovirus replication when overexpressed, we performed g

240 mphocytes are critical for controlling acute norovirus replication while simultaneously contributing

241 still represent valuable research tools for norovirus research.

242 Samples were analyzed for norovirus RNA by reverse transcription quantitative poly

243 The presence of norovirus RNA in submicrometre particles indicates that

244 Airborne norovirus RNA was also strongly associated with a shorte

245 Norovirus RNA was found in 21 (24%) of 86 air samples fr

246 m 5-215 copies/m3, and detectable amounts of norovirus RNA were found in particles <0.95 um and >4.51

247 e a succeeding outbreak, tested positive for norovirus RNA.

248 l severity scores were highest for inpatient norovirus, rotavirus, and Shigella/EIEC cases.

249 and diarrhea were observed, particularly for noroviruses, rotaviruses, enterotoxigenic Escherichia co

250 Following infection, anti-norovirus salivary immunoglobulin G (IgG) rises steeply

251 as 92.8%, 84.9%, 93.0%, 100%, and 95.6%, for norovirus, sapovirus, astrovirus, rotavirus, and adenovi

252 ns were 7.3%, 4.5%, 3.5%, 2.4%, and 1.2% for norovirus, sapovirus, astrovirus, rotavirus, and adenovi

253 ntial diagnosis of enteric disease caused by norovirus, sapovirus, astrovirus, rotavirus, and adenovi

254 Emergent strains of human norovirus seed pandemic waves of disease.

255 Twenty-four clusters of related norovirus sequences ("sequence clusters") were observed,

256 Thirty-three percent of norovirus sequences were linked, suggesting nosocomial t

257 attributable pathogens included astrovirus, norovirus, Shigella, Salmonella, ETEC, sapovirus, and ty

258 f human norovirus disease and representing a norovirus small animal disease model in wild-type mice.

259 underscores the need for the development of norovirus-specific drugs.

260 Norovirus-specific immunoglobulin A (IgA) levels in base

261 Hence, we sought to generate human norovirus-specific T cells (NSTs) that can recognize dif

262 Norovirus-specific T cells comprised both CD4+ and CD8+

263 Norovirus-specific T cells were generated from periphera

264 there are frequent introductions of multiple norovirus strains with extensive onward nosocomial trans

265 0 years have been caused by type GII.4 human norovirus strains.

266 VADR has been used for Norovirus submissions since May 2018 and for Dengue viru

267 produce a blue color in the presence of this norovirus, such that the color intensity provides the vi

268 e and mustard with Rotavirus (RV) or a human norovirus surrogate (Tulane virus, TV) and then disinfec

269 e most sensitive detection of norovirus or a norovirus surrogate achieved to date using a biosensor a

270 data highlight the importance of continuous norovirus surveillance and provide important information

271 ferent scenario which assumed that 66.6 % of norovirus-symptomatic food workers and 0% of postsymptom

272 Murine norovirus (MNoV) is a model norovirus system because MNoV replicates robustly in cel

273 Our findings identify immunodominant human norovirus T-cell epitopes and demonstrate that it is fea

274 nd validate a noninvasive method to diagnose norovirus to complement stool diagnostics and to facilit

275 istics, such as symptoms or demographics, in norovirus transmissibility is poorly understood.

276 Understanding norovirus transmission dynamics is vital for improving p

277 based assay will be a useful tool to monitor norovirus transmission in high-risk settings such as day

278 vomit are more infectious and tend to drive norovirus transmission in U.S. nursing home norovirus ou

279 f symptoms and other case characteristics in norovirus transmission using the reproduction number (RE

280 While diarrhea also plays a role in norovirus transmission, it is to a lesser degree than vo

281 s after administration of an investigational norovirus vaccine and were compared with those measured

282 for improving preventive measures, including norovirus vaccine development.

283 nt virus-like particle (VLP)-based candidate norovirus vaccine formulations in adults.

284 in vitro model systems in which to evaluate norovirus vaccines and treatment.

285 rtant information on which strains pediatric norovirus vaccines should protect against.

286 nses in a phase 2 trial of Takeda's bivalent norovirus virus-like particle (VLP) vaccine candidate in

287 Levels of antibodies to both candidate norovirus VLP formulations persisted above baseline leve

288 This is the first time norovirus VLPs have been shown to interact specifically

289 Although norovirus VLPs have been thought to exist in a single-si

290 Norovirus was detected in 109 (18%) of 613 children with

291 Norovirus was detected year-round but peaked during wint

292 C. difficile and norovirus were detected year-round with a fall/winter pr

293 C. difficile and norovirus were leading AGE pathogens in outpatient and h

294 Clostridioides difficile and norovirus were most frequently detected among inpatients

295 sporadic cases and outbreaks, GII genogroup noroviruses were most prevalent (90.1% and 83.3%) with G

296 sporadic cases and outbreaks, GII genogroup noroviruses were most prevalent (90.1% and 83.3%), with

297 jurisdictions, and consider testing food for norovirus when appropriate.

298 entification of a new antiviral scaffold for norovirus, which inhibits human norovirus replication at

299 a prevalent model system for studying human norovirus, which is the leading cause of gastroenteritis

300 rovided novel insights into the evolution of norovirus within an immunocompromised host.