戻る
「早戻しボタン」を押すと検索画面に戻ります。 [閉じる]

コーパス検索結果 (１語後でソート)

通し番号をクリックするとPubMedの該当ページを表示します
1 g]isoquinolin-5-yl)isobenzo-furan-1(3H)-one (noscapine).
2 tic arrest and then apoptosis in response to noscapine.
3 bstituted aromatic halides including 9-bromo noscapine.
4 ignificantly lower than [9-Br-Nos]IBr(2) and Noscapine.
5 averine, papaverine, glaucine, rotundine and noscapine.
6  involved in the formation of papaverine and noscapine.
7 looxygenase-2 promoter was also inhibited by noscapine.
8 e antiproliferative and apoptotic effects of noscapine.
9 1 in the cellular response to treatment with noscapine.
10 fect tubulin polymerization differently from noscapine.
11 at mitosis at concentrations much lower than noscapine.
12 bserved arrest in mitosis in the presence of noscapine.
13 rt herein that two brominated derivatives of noscapine, 5-bromonoscapine (5-Br-nosc) and reduced 5-br
14 hat the cytotoxic agent 7A-O-demethoxy-amino-noscapine (7A-aminonoscapine) binds to the colchicine si
15    Here, we present one such analog, 9-nitro-noscapine (9-nitro-nos), which binds tubulin and induces
16 ike the other existing drugs in this regime; noscapine (a non-opioid alkaloid) is testified to be an
17  our workflow to the biosynthetic pathway of noscapine, a benzylisoquinoline alkaloid (BIA) with a lo
18                                              Noscapine, a benzylisoquinoline alkaloid derived from op
19                                              Noscapine, a microtubule-interfering agent, has been sho
20                                              Noscapine, a phthalideisoquinoline alkaloid derived from
21                             We now show that noscapine, a tubulin-binding agent, increases the time t
22 ndantly expressed in opium poppy stems where noscapine accumulation is highest among plant organs.
23  families, that were tightly correlated with noscapine accumulation.
24 levels resulted in a significant decrease in noscapine accumulation.
25 n vivo, and we describe a novel mechanism of noscapine action through EP2 prostaglandin E2 receptor-m
26                                              Noscapine alone suppressed proliferation of human leukem
27                                              Noscapine also abrogated the inducible expression of pro
28                                 Importantly, noscapine also demonstrated the ability to significantly
29                                              Noscapine also suppressed phosphorylation and nuclear tr
30 is study, we found that apoptosis induced by noscapine, an anti-microtubule drug previously shown to
31   Here we demonstrate that a tubulin-binding noscapine analog, (R)-9-bromo-5-((S)-4,5-dimethoxy-1,3-d
32                                   Thus, many noscapine analogs with different functional moieties at
33                                  A number of noscapine analogues possessing various modifications hav
34 ), have higher tubulin binding activity than noscapine and affect tubulin polymerization differently
35 lytic activity toward oxidation of morphine, noscapine and heroin at reduced overpotentials in wide p
36 ulse voltammetric determination of morphine, noscapine and heroin yields calibration curves with the
37  for simultaneous determination of morphine, noscapine and heroin.
38 ngements of prominent isoquinoline alkaloids Noscapine and Hydrastine.
39  these compounds bound to tubulin shows that noscapine and its 7-aniline derivative do not compete fo
40                                              Noscapine and its 7-hydroxy and 7-amino derivatives were
41  of three major narcotic components, heroin, noscapine and morphine at micromolar concentration witho
42 ll line and compared it to [9-Br-Nos]IBr(2), noscapine and Paclitaxel.
43  pharmaceutical compounds codeine, morphine, noscapine and papaverine.
44 ive discusses the advancing understanding of noscapine and related analogues in the fight against mal
45  improvement in the commercial production of noscapine and related bioactive molecules.
46 isiae to achieve the microbial production of noscapine and related pathway intermediates, complementi
47                                Nevertheless, noscapine and the two derivatives all affect the attachm
48 ylisoquinoline alkaloids including morphine, noscapine, and papaverine, in the specialized cytoplasm
49 ther propose that the anticancer activity of noscapine arises from a bioactive metabolite that binds
50                           Cells treated with noscapine arrest at mitosis with nearly normal bipolar s
51                       Interestingly, whereas noscapine-arrested cells have nearly normal bipolar spin
52 ave previously discovered the opium alkaloid noscapine as a microtubule interacting agent that binds
53 ave previously identified the opium alkaloid noscapine as a microtubule interacting agent that binds
54 the naturally occurring antitussive alkaloid noscapine as a tubulin-binding agent that attenuates mic
55                                 We show that noscapine binds stoichiometrically to tubulin, alters it
56 eviously that an antitussive plant alkaloid, noscapine, binds tubulin, displays anticancer activity,
57 mits set for morphine, codeine, thebaine and noscapine by Hungarian legislation.
58                                 Furthermore, noscapine causes apoptosis in many cell types and has po
59                                Consequently, noscapine could be a valuable chemotherapeutic agent, al
60                                 In contrast, noscapine did not activate PKA in human bronchial or alv
61                                              Noscapine did not affect gross microtubule content in HL
62 ies reveal that even at high concentrations, noscapine does not alter the tubulin polymer/monomer rat
63                            Here we show that noscapine does not compete with paclitaxel for tubulin b
64 t, unlike many other microtubule inhibitors, noscapine does not significantly promote or inhibit micr
65 s denatonium, quinine, dextromethorphan, and noscapine, dose-dependently relaxed the pre-contracted g
66 required for subsequent apoptosis induced by noscapine, establishing a link between the two events.
67 cence staining of microtubules after 24 h of noscapine exposure at 20 muM elucidated chromosomal abno
68 constitute a 14-step biosynthetic pathway of noscapine from the simple alkaloid norlaudanosoline by e
69                    Here, we reconstitute the noscapine gene cluster in Saccharomyces cerevisiae to ac
70 more than a century ago, the biosynthesis of noscapine has not been established.
71                                              Noscapine has since been discovered to arrest cells at m
72 ing enzymes responsible for the synthesis of noscapine have been recently discovered to be clustered
73 ved in the conversion of N-methylcanadine to noscapine have not been identified.
74 vation of PKA and the antifibrotic effect of noscapine in HLFs were blocked by the EP2 prostaglandin
75 ), which mediated the antifibrotic effect of noscapine in HLFs, as assessed with the PKA inhibitor, P
76 c and Rd 5-Br-nosc are also more active than noscapine in inhibiting the proliferation of various hum
77                 However, the biosynthesis of noscapine in opium poppy has not been established.
78 the first committed step in the formation of noscapine in opium poppy.
79 ioavailable and is 250-fold more potent than noscapine in reducing cell proliferation in rapidly divi
80 MT3 that correlated with the accumulation of noscapine in the eight cultivars.
81 findings thus indicate a great potential for noscapine in the treatment of paclitaxel-resistant human
82 or the first time the antifibrotic effect of noscapine in vitro and in vivo, and we describe a novel
83 posed pathway leading from (S)-reticuline to noscapine includes (S)-scoulerine, (S)-canadine, and (S)
84 ansfection with dominant-negative JNK blocks noscapine-induced apoptosis.
85                                              Noscapine inhibited TGF-beta-induced differentiation of
86                                        Thus, noscapine inhibits the proliferation of leukemia cells a
87 valuated novel 9'-substituted suzuki-coupled noscapine ionic liquid(s) as effectual anticancer drug(s
88                                              Noscapine is a benzylisoquinoline alkaloid produced in o
89                                              Noscapine is a natural alkaloid that is used as an antit
90                                              Noscapine is a phthalideisoquinoline alkaloid investigat
91                                              Noscapine is a potential anticancer drug isolated from t
92                                              Noscapine is an antitumor alkaloid from opium poppy that
93          Radiotracer studies have shown that noscapine is derived from the protoberberine alkaloid (S
94                                      Because noscapine is water-soluble and absorbed after oral admin
95                      An alkaloid from opium, noscapine, is used as an antitussive drug and has low to
96 a necessary but not sufficient condition for noscapine-mediated apoptosis.
97 angiogenesis in tumors, we hypothesized that noscapine mediates its effects by modulating the NF-kapp
98 sed a significant reduction in the levels of noscapine, narcotoline, and a putative downstream secobe
99 investigated the chemo-sensitizing effect of Noscapine (Nos) at low concentrations in conjunction wit
100              We studied in silico docking of noscapine onto tubulin, combined with calculations of su
101 pium alkaloids (morphine, codeine, thebaine, noscapine, papaverine and narceine) in poppy seeds and b
102                                We found that noscapine potentiates apoptosis induced by cytokines and
103      We suggest that the 7A-methoxy group of noscapine prevents binding to tubulin due to a steric cl
104 t were most abundant in aerial organs, where noscapine primarily accumulates.
105 oding five distinct enzyme classes in a high noscapine-producing poppy variety, HN1.
106 ntifibrotic effects of the antitussive drug, noscapine, recently found to bind microtubules and affec
107 vative, thereby advancing protoberberine and noscapine related drug discovery.
108 mitosis and resume a normal cell cycle after noscapine removal.
109 r results demonstrate that p.o.-administered noscapine significantly inhibits the progression of mela
110                                 Furthermore, noscapine stimulated a rapid and profound activation of
111                                              Noscapine suppressed both inducible and constitutive NF-
112 ates, allowing gene function to be linked to noscapine synthesis and a novel biosynthetic pathway to
113                          We demonstrate that noscapine-treated murine melanoma B16LS9 cells do not ar
114 y, cell cycle distribution, and apoptosis on noscapine treatment in four cell lines derived from the
115                        Our results show that noscapine treatment increases the expression of p53 over
116                                  Therapeutic noscapine treatment resulted in a significant attenuatio
117 c murine model of established s.c. melanoma, noscapine treatment resulted in an 85% inhibition of tum
118 ly, these cells undergo apoptotic death upon noscapine treatment, accompanied by activation of the c-
119 n accumulation in a time-dependent manner on noscapine treatment.
120 the inhibition of tumor volume observed when noscapine was combined with paclitaxel.
121             Analogues of the natural product noscapine were synthesized and their potential as antitu
122             Analogues of the natural product noscapine were synthesized, and their potential as antit
123  higher affinity than the founding compound, noscapine, without changing total microtubule polymer ma

 
Page Top