ライフサイエンスコーパス: notochordal

1 enitor and mature NP cells, corresponding to notochordal and chondrocyte-like cells, respectively.

2 l plate and at lower levels in the posterior notochordal and neural regions during convergent extensi

3 gh cell motility continues, and the anterior notochordal and somitic mesoderm differentiate in the pr

4 the pre-involution marginal zone, posterior notochordal and somitic mesoderm do not differentiate.

5 The emergence of notochordal brachyury expression could be attributed to

6 Humans and other species in which notochordal cells (NCs) disappear to be replaced by chon

7 l levels of nutrients may reduce the loss of notochordal cells and PG in the IVD.

8 eration is initiated by the disappearance of notochordal cells and progressive loss of proteoglycan (

9 der the in-vivo nutrient conditions while NP notochordal cells are likely to be more vulnerable to re

10 recordings show that presumptive somitic and notochordal cells move out of the roof of the gastrocoel

11 Bgm1 dysregulates eIF6 localization in notochordal cells, affecting nucleocytoplasmic transport

12 and do not undergo CE like the Gsc-negative notochordal cells, which subsequently emerge from the or

13 ortions of different tissue types, including notochordal cells.

14 , with prominent intracellular expression in notochordal cells.

15 This suggests the possibility of notochordal defects.

16 omas, and in chordoma, a rare cancer showing notochordal differentiation, TBXT acts as a putative onc

17 lignant, often incurable bone tumour showing notochordal differentiation.

18 doma is a rare malignant tumor demonstrating notochordal differentiation.

19 articipate in this process by modulating the notochordal expression of HNF-3 beta.

20 bsence of DLHPs at high spinal levels, where notochordal expression of Shh is strong.

21 hich seems likely to be regulated by another notochordal factor.

22 is dependent on brachyury (TBXT), a hallmark notochordal gene and transcription factor, and shares hi

23 Finally, our results demonstrate that the notochordal inducer also induces the reconstituted Hense

24 ion reduced the transcription of osterix and notochordal marker T by 40-75%.

25 %, and reduced the transcription of osterix, notochordal markers and chondrocytic markers by 60-80%.

26 a key mediator of FGF signaling in trunk non-notochordal mesoderm, since spadetail expression is regu

27 ochord, although adult NP lacks identifiable notochordal (NC) cells.

28 The results showed notochordal NP and AF cells responded differently to cha

29 nsgene can be reliably restricted to muscle, notochordal, or neuronal tissues.

30 ecular expression pattern derived from their notochordal origin, and reside in N-cadherin (CDH2) posi

31 Chordomas are rare tumors of notochordal origin, most commonly arising in the sacrum

32 hree cases of chordoma, a cancer of presumed notochordal origin.

33 tial roles in morphogenesis of the posterior notochordal plate (the node) and the midline.

34 de in mouse, Kupffer's vesicle in zebrafish, notochordal plate in rabbit and gastrocoel roof plate in

35 otochord precursors from the tail bud to the notochordal plate seems impaired, whereas notochord form

36 pithelial organization in the mouse node and notochordal plate through the assembly and radial interc

37 d-type cells in the midline neural plate and notochordal plate, consistent with a cell-autonomous dis

38 hat Cripto is essential for formation of the notochordal plate, prechordal mesoderm and foregut endod

39 rior-most region of the notochord and in the notochordal plate.

40 e streak, the head process, and the node and notochordal plate.

41 nnexin43.4 expression remained absent in the notochordal precursor cells and was lost in the tail bud

42 Despite lacking normal notochordal precursor cells, the notochord still forms i

43 Chordoma is a rare tumor originating from notochordal remnants that is usually diagnosed during mi

44 g the hypothesis that chordoma develops from notochordal remnants.

45 Notochordal signaling induces midline bending and simult

46 Consistent with the disorganization of notochordal signals in the alpha5-null embryos, reduced

47 urces of the missing laminin chain, although notochordal sources are also sufficient for rescue.

48 -null embryos due to (1) degeneration of the notochordal tissue structure, and (2) non-maintenance of

49 a, a rare, aggressive tumor originating from notochordal tissue, shows loss of SMARCB1 expression, a

50 grafted cells from each region give rise to notochordal tissue.

51 hord-inducing signals and differentiate into notochordal tissue.

52 but, in the absence of interactions with non-notochordal tissues, they neither invaginate nor converg

53 We reveal somatic duplications of the notochordal transcription factor brachyury (T) in up to

54 doma in 104 cases, revealing duplications in notochordal transcription factor brachyury (T), PI3K sig

55 that the spadetail gene is required for non-notochordal trunk mesoderm formation; spadetail mutant e

56 d tail, the pathways activated by FGF in non-notochordal trunk mesoderm have been uncertain.