ライフサイエンスコーパス: novel

1 ications for the screening and evaluation of novel adjuvants.

2 d ATPalphaS, we were also able to identify a novel agonist, the synthetic analogue 2-fluoro-ATP, and

3 This study proposed a novel analytical method for the separation and determina

4 Here, we devised novel analytical procedures enabling extensive and syste

5 The human FBN1+ FAP cell subtype is novel and a corresponding FBN1+ FAP cell type was also f

6 Here, a novel and cost-effective strategy is proposed to boost t

7 Here we identify a novel and critical function of IKK2 and its co-factor NE

8 180-bp and TR1 sequences, recruit their own novel and divergent kinesin-14 family members to form ne

9 aper-based sensor was then engineered with a novel and highly specific peptide nucleic acid (PNA) as

10 Our method relies on the novel and nontrivial adaption and application of spaced

11 rment of NR2B/PSD-95/MAP1A pathway, may be a novel and preferential option to ameliorate alpha-syn-in

12 A novel and promising application of sub-millimeter fMRI i

13 MRI-guided radiotherapy is a novel and rapidly evolving technology that might enhance

14 nt interactions are highly specific and that novel and stably inherited methylation variants are of b

15 files, these results suggest that ML417 is a novel and uniquely selective D3R agonist that may serve

16 upfront treatments such as chemotherapy and novel anti-androgen agents has further hampered progress

17 Novel antibiotics are urgently needed to combat multidru

18 Among these, the combined use of two novel antigens and one previously described antigen prov

19 lobin and are drug targets for the design of novel antimalarial agents.

20 lasmodial l-lactate transporter, PfFNT, as a novel antimalarial drug target.

21 zyme, providing a new approach to facilitate novel applications.

22 In this project, we demonstrate a novel approach aimed at protecting islets before Tx in n

23 Here, we present a novel approach for in situ extraction of organic compoun

24 These results demonstrate that this novel approach has promise for overcoming two major issu

25 s through their phenolic moiety represents a novel approach to enediyne ADC creation, while the pharm

26 targeting of epigenetic modulators offers a novel approach to the treatment of multiple diseases.

27 A novel approach was employed to quantify and value nitrog

28 acts P. aeruginosa behavior, and may inspire novel approaches for controlling P. aeruginosa infection

29 of the thioxotriazinoindole scaffold of the novel AR inhibitor cemtirestat by replacement of sulfur

30 um graveolens L.) as a model herb, we reveal novel associations between metabolite profile and sensor

31 associations at p < 5 x 10(-9), including 71 novel associations not found in EUR populations.

32 d chronic kidney disease in those with gout, novel associations of gout with other comorbidities have

33 Novel associations of sputum and oral microbiota to immu

34 d molecular dynamics simulations can provide novel atomic resolution details regarding mechanostabili

35 sistance crisis, there is an urgent need for novel bacterial targets and antibiotics with novel modes

36 This novel BAT-Kiss1r KO phenotype was of greater magnitude i

37 al network model of the inferior olive and a novel Bayesian model averaging approach.

38 These results provide novel behavioral and brain-based targets for treatment o

39 ries of genome-wide experiments coupled to a novel bioinformatic analysis approach.

40 We identified a novel, biological difference between RV and LV fibroblas

41 to retrieve both previously established and novel biologically relevant patterns, demonstrating the

42 A novel bis-pillar[5]arene dicarboxylic acid self-assemble

43 These results demonstrate that a novel bivalent Ebola VLP vaccine elicits strong humoral

44 For video stabilization, we adopt a novel brightness-invariant optical flow algorithm that h

45 lasses of antibiotics are rare, structurally novel broad-spectrum antibiotics exceptionally so.

46 prostate cancer gene (HOXB13), as well as a novel candidate gene (ILDR1), which encodes a receptor h

47 revealed that expression levels of known and novel candidate genes (putatively encoding beta-ketoacyl

48 6,7), raise doubts about others and identify novel candidates, including point mutations in the 5' re

49 Review, we discuss the innovative designs of novel CAR T cell products that are being developed to in

50 s and possible solutions for improving these novel catalytic materials are also highlighted.

51 nded known associations and reported several novel causal associations providing important insights a

52 These findings represent a novel cellular mechanism that supports reliable synaptic

53 e, and how PARP inhibitors have emerged as a novel clinical therapy to treat homologous recombination

54 Novel clinical trial designs offer potential solutions b

55 urrences across RBPs enable the discovery of novel co-interacting RBPs.

56 ith higher sensitivity and resolution, using novel collimator designs based on tungsten.

57 Our unique study uses a novel combination of human association analysis, CRISPR

58 aqueous medium, in particular by devising a novel composite material by coupling DMASnBr(3) to g-C(3

59 C model (FGbeta(3) cells) was used to test a novel compound (PAWI-2) to eradicate CSCs.

60 We identified 21 novel compounds that selectively inhibit this enzyme.

61 assay's ability to identify and characterize novel compounds with specific cellular potency for eithe

62 mmunotherapy, but are less well studied with novel compounds.

63 neuropsychological assessments to develop a novel computational phenotyping method that groups brain

64 The novel concept of Well-Associated Proteins (WAPs) introdu

65 ructure of DDM and evaluated the activity of novel congeners in triple negative breast and ovarian ca

66 We report a novel conjugation of N-terminal cysteines (NCys) that pr

67 The outbreak of a novel coronavirus (2019-nCoV) represents a pandemic thre

68 rst known community transmission case of the novel coronavirus disease (COVID-19) in the United State

69 be the use of discarded wound dressings as a novel, cost effective, accessible, and non-invasive meth

70 nto the sequence requirements for developing novel CPPs for transcellular delivery of cargo.

71 We previously identified a novel cullin-RING E3 ligase utilizing F-box only protein

72 To combat this effect, this work assessed a novel cyclical aggregation as a means of expanding MSCs

73 provide mechanistic insights into how these novel cyclotides interact with and permeabilize cell mem

74 The development of novel data-driven functional analytic tools has enabled

75 lied during the production of black onion, a novel derived product made from fresh onion, produces ch

76 Capitalizing on this knowledge, novel diagnostic tools can be developed to guide clinica

77 We designed a novel digital therapeutic that modifies patient-selected

78 lational research opportunity for uncovering novel disease mechanisms and therapies.

79 Novel drug development, testing and progression to clini

80 netics and holds great potential to identify novel drug targets and vaccine development.

81 such, we show that this system presents as a novel druggable target for the treatment of Alzheimer's

82 APIO-EE-07, a novel dual-target inhibitor of RSK1 and MSK2, can suppre

83 neering approach, for example, the design of novel dynamic functional soft materials for future use i

84 In addition to highlighting novel ecosystem impacts of alternate bioenergy landscape

85 These strategies include the use of novel electrolytes such as superconcentrated electrolyte

86 eosin (sixfold higher protein abundance) and novel endoplasmic reticulum morphology.

87 We and others have previously identified novel eNOS interactors, including G protein-coupled rece

88 iety-like behaviors, cannabimimetic effects, novel environment exploratory behavior, pre-pulse inhibi

89 tion can be enhanced by the exploration of a novel environment presented during a vulnerable early ph

90 iding a means to engineer crops for entirely novel environments, such as those in space travel.

91 reases the likelihood of detecting plausible novel enzyme-chemical relationships.

92 sed approaches and the pathobiology of these novel events.

93 These findings provide novel evidence for the participation of cerebellar struc

94 o our knowledge, the first one that provides novel evidence-based information for risk-adapted starti

95 The formation of memory for a novel experience is a critical cognitive capacity.

96 tions: a famous, highly familiar face with a novel face or two novel faces while undergoing fMRI.

97 ighly familiar face with a novel face or two novel faces while undergoing fMRI.

98 tein interaction detection system as well as novel FAP-based sensors.

99 ral determinant of a compartment composed of novel fibril-like substructures, which we identify here

100 Notably, we report the novel finding that stimulation of VLPO glutamatergic neu

101 These novel findings identify that transvalvular unloading lim

102 These novel findings need to be investigated for consistency i

103 These novel findings provide a better understanding of both th

104 meric antigen receptor (CAR) T cells offer a novel form of CAR-T-cell product that is available for i

105 form of social learning is argued to reflect novel forms of social hierarchy in human societies, and,

106 These novel formulations will address drug delivery challenges

107 regions in known CFSs and identification of novel fragile sites.

108 This paper aims to illustrate a novel framework for conceptualizing, collecting, and ana

109 SULT1E1 appears to have a novel function in the pathogenesis of AKI.

110 sassembly, and suggest cargo remodeling as a novel function of dynein adaptors.

111 roles in the adult pancreas and highlight a novel function of the Delta/Notch pathway in beta-cell i

112 multiple hypothalamic nuclei and elucidate a novel functional mechanism for the preoptic DA neurons i

113 with preserved 2D electronic properties and novel functionalities.

114 e novo-designed protein, conferring entirely novel functions on the peptide scaffolds.

115 able geometries that may be customizable for novel functions.

116 in the pathway to discovering materials with novel functions.

117 , allowing a more facile characterization of novel gene products and subcellular complexes.

118 Using a highly novel gene therapy approach in a canine, rapid atrial pa

119 approach led to the identification of seven novel genetic causes of monogenic diabetes, six by exome

120 roteinemia inflammatory (PAMI) syndrome is a novel genetic disorder, causing hypercalprotectinemia an

121 would enhance statistical power to identify novel genetic loci for depression.

122 The authors identified novel genome-wide significant associations near genes in

123 wide association study (GWAS) identified one novel genomic risk locus on chromosome 8 (lead SNP rs170

124 cation was largely driven by colonization of novel geographic areas and subsequent evolution in isola

125 Using a novel GLD model, we show that cross-correction does not

126 Despite excitement around ProQ as a novel global RNA-binding protein, and its potential to s

127 study is aimed to produce and characterize a novel gluten-free ingredient from oat through sprouting

128 In this study, we implemented novel golden angle radial MRI acquisition technique to s

129 munity dynamics in this population utilizing novel graphical network models that can explicitly incor

130 Finally, we identify a novel group of CA1 neurons that robustly encode freeze b

131 SK3beta can facilitate the identification of novel GSK3beta inhibitors of high potency and specificit

132 Novel H1N2 influenza A viruses (IAVs) in swine have been

133 In this study, we describe a novel high throughput, micro-macro approach for the iden

134 the colocalization of-and interplay between-novel high-penetrance monogenic variants and common vari

135 neration BTK inhibitor, with zanubrutinib, a novel highly selective BTK inhibitor, in patients with W

136 a competitive displacement assay to identify novel hit matter.

137 We propose a novel hourglass shaped lattice metastructure that takes

138 rison options that are designed to assist in novel hypothesis generation, as well as data management,

139 The findings from this work puts forth the novel hypothesis that the immunotherapeutic efficacy of

140 s for 459 cell traits at 70 loci (53 of them novel) identifying several molecules and mechanisms invo

141 therapies, anti-inflammatory therapies, and novel immunometabolic agents.

142 The genesis of novel influenza viruses through reassortment poses a con

143 rleaved processes: strengthening encoding of novel information and guiding exploration based on prior

144 e libraries (DELs) have enabled discovery of novel inhibitors for many distinct protein targets of th

145 In summary, this study provides novel insight into a possible mechanism for CBD interact

146 This study provides for the first time a novel insight into the molecular basis of sinonasal muco

147 users, making it a powerful tool for gaining novel insights into genome evolution.

148 Exciting recent data have provided novel insights into how these ABO effects are modulated

149 n or proteostatic pathway of mHTT, providing novel insights into such pathological activities.

150 /Li(x)Si/inner-SEI/outer-SEI), thus offering novel insights into the impact of SEI homogeneities on t

151 Overall, these data provide novel insights into the signalling molecules and mechani

152 t powerful neutrophilic oxidants may provide novel insights into treatment options that potentially c

153 Together, our findings highlight the novel interaction between endocan and EGFR and new oppor

154 ognition motifs for fullerenes, facilitating novel intermolecular, solvent tunable ground state elect

155 reward learning may be a viable approach for novel interventions in bipolar disorder.

156 uman immunodeficiency virus (HIV) has driven novel interventions, such as antiretrovirals, for pre-ex

157 (2019) describe how the novel KRAS-G12C inhibitor AMG 510 can potentiate immune

158 We report a novel lab-on-a-chip device integrating a multigate elect

159 nts in understanding TIM3 biology, including novel ligand identification and the discovery of loss-of

160 eening approach led to the discovery of this novel ligand, which was successfully applied in the prep

161 ctively, these findings unveil the role of a novel lncRNA in vascular inflammation by cis-regulating

162 n independent GWAS, including one of the two novel loci.

163 This pattern was negatively controlled by a novel long noncoding RNA (lncRNA) that we named Stem Cel

164 In contrast, our data define a novel macrophage population that controls overwhelming i

165 Here, a novel magnetic shape memory polymer composite is reporte

166 Gal d 7 represents a novel major chicken meat allergen.

167 rational design and holistic engineering of novel materials for more capable biocompatible triboelec

168 pt of aurophilicity and its use in designing novel materials is a true example of innovation on a mul

169 A novel mathematical-statistical framework that included E

170 Collectively, our study uncovered a novel mechanism by which AtPRMT3 cooperates with RPS2B t

171 Our results demonstrate a novel mechanism by which cystic epithelial cells stimula

172 These results support a novel mechanism for the selection of striatal circuit co

173 Ki plus MET inhibitor may delay or prevent a novel mechanism of acquired MEKi resistance, with clinic

174 = 1-2 uM), suggesting that BCH070 acts via a novel mechanism of action.

175 s of transpeptidase substrates, (b) reveal a novel mechanism of stereochemical editing within peptido

176 ynaptogenesis and synaptic transmission by a novel mechanism that is independent of neurexins and neu

177 lation of vascular tone and BP and suggest a novel mechanism, and therapeutic target, for aging-induc

178 The findings provide novel mechanistic insights into receptor-operated TRPC4

179 nderstanding of ionization that could enable novel membrane design.

180 min with serially diluted antibiotics with a novel, membrane-type micromixer consisting of two circul

181 Here, a novel method for targeted near-infrared (NIR) fluorescen

182 Here, we present and validate a novel method of MRI velocity-encoding combined with a mo

183 Herein, we introduce a novel method of photodynamic effect evaluation through i

184 Herein, we established a novel method to quantify SCFAs by coupling amidation der

185 Using a novel method to track neuronal firing, we analyzed micro

186 work-loop technique can provide an important novel method with which to assess detailed mechanisms of

187 Here, we present a novel method, Metalign, that performs efficient and accu

188 Novel methods are emerging for more efficiently sourcing

189 are time consuming and they do not consider novel microbial sequences when aligned with the referenc

190 issed by Illumina-based methods, including a novel micropia-like element that has recently invaded th

191 Metabolic-modeling, using a novel model for MG1655 and continuous weighing factor th

192 novel bacterial targets and antibiotics with novel modes of action.

193 In addition, three novel molecules (UBXN4, MFSD12, and ACTR6) from RNA-seq

194 These novel monitoring techniques could potentially be used to

195 electrochemical applications, which concerns novel monomer design, chemical methodology/strategy esta

196 To further analyze novel monomers, we applied SD to the set of recently gen

197 CP) with human CD73, we designed a series of novel monophosphonate small-molecule CD73 inhibitors.

198 Here, we identified a novel mTORC1-interacting protein called protein kinase A

199 , these peptide-based catalysts have enabled novel multifunctional substrate activation modes and unp

200 anostability and can serve as a platform for novel mutagenesis studies as well as a point for compari

201 genes MFRP and TMEM98 were negative, while a novel mutation, Thr518Met was detected in MYRF.

202 ults suggest the potential of solenopsins as novel natural drugs against neglected parasitic diseases

203 The objective of this study was to test a novel neuromodulation therapy of stimulation of epicardi

204 In this study, we identified a novel neutralizing epitope in the head region recognized

205 This paper proposes a novel nonlinear model of cascade failure in weighted com

206 erges in the OT within minutes of learning a novel odor-reward association, whereas the pPC lacks an

207 ay high conductivities and mobilities toward novel (opto)electronic devices.

208 Avadomide (CC-122) is a novel oral cereblon-modulating agent with promising acti

209 We examined the structure of two of the novel orbitides by NMR, finding one had a definable stru

210 s as being Fermi surface-driven, revealing a novel ordering mechanism in this nickelate that reflects

211 locks in which animals learned the values of novel pairs of objects, than across blocks in which they

212 segmented viruses and is the main source of novel pathogenic influenza viruses.

213 Subsequently, a severe and novel pediatric disorder termed multisystem inflammatory

214 Crystal structures of delta revealed novel pentameric folding repeats, which we term beta-bra

215 (18)F-flurpiridaz is a novel PET MPI agent with superior image and defect resol

216 Fifteen stable novel phases with in-plane chemical ordering are identif

217 Here, we introduce a novel platform that allows IC-FPOP to occur in a sterile

218 be of immense consequence towards developing novel point-of-care hematological analyzers for resource

219 ation of nonaromatic 2H-imidazoles to afford novel polyfluoroarylated azaheterocycles.

220 for this reason the system could represent a novel potential therapeutic target for DS.

221 ollowing the invasion and proliferation of a novel predator (spiny waterflea, Bythotrephes longimanus

222 with clinical outcomes should help identify novel predictive biomarkers and features as well as ther

223 graphene van der Waals heterostructures with novel properties and functionality not accessible by con

224 differentiation-related factor 1 (EDF1) as a novel protein recruited to collided ribosomes during tra

225 We developed a novel protocol to measure transporter-mediated histidine

226 from human cancer RNA-Seq, where we identify novel putative biomarker genes in different tumors, and

227 x cycle, we have successfully harnessed this novel radical strain-release amination as part of a mult

228 iated with this phenomenon, we identified 18 novel RALF-likes from multiple species of RKNs and showe

229 density of NMDARs, which are the targets of novel rapid-acting antidepressants.

230 ctivating transcription factor 4 (ATF4) as a novel regulator of fetal gamma-globin gene expression in

231 rtance of DC-mediated priming in identifying novel regulators of T cell differentiation.

232 within the bulk nuclear nanoenvironment as a novel regulatory framework for gene expression.

233 r variables during the same period to derive novel resilience phenotypes.

234 ity and determine previously undescribed and novel resistance variants.

235 These novel results are of relevance for breeding programs, an

236 ynyl-2-fluoro-2'-deoxyadenosine [EFdA]) is a novel reverse transcriptase-translocation inhibitor.

237 Using a novel robust analysis pipeline, we found broad regions w

238 Collectively, our results show a novel role for MondoA in the regulation of early vertebr

239 h ubiquitinated OAT1 degrades and unveiled a novel role of anticancer drugs bortezomib and carfilzomi

240 CFTR trafficking and function and suggested novel roles of EGR1 and SGK1 in the disease state.

241 r accurate antibiotic prescribing and thus a novel route to tackling the global challenge of AMR.

242 array of substituents is tolerated with this novel scaffold that increased cellular metabolic rates i

243 roxanthic acid A as the founding member of a novel secondary metabolite family.

244 ic influences upon the environment, creating novel selective pressures to which organisms must adapt.

245 A simple electrochemical method employing a novel semi-circular potential sweep voltammetry on a gla

246 Rolipram may therefore be a potential novel sepsis treatment, one that would bypass the time-c

247 We propose a novel severity score specifically for COVID-19 to help p

248 ed on Ag using microscopy, spectroscopy, and novel simulation methods.

249 Here, we discovered a novel size law that connects cell size to the inverse of

250 Starting from novel spirocyclic intermediates, we exemplified the prep

251 nal moulding and granulation, and also via a novel spray-drying powdering process without additives,

252 In summary, we introduce a novel statistical approach to systematically evaluate de

253 o humans through the occasional emergence of novel strains with enhanced zoonotic potential.

254 ted in behavioral regulation, and may inform novel strategies for therapeutic and preventative interv

255 ally, we highlight new areas of research and novel strategies that may shed light on this complex inf

256 ings suggest that targeting c-Myc may unlock novel strategies to combat asthma or asthma exacerbation

257 exocytosis proteins in T2D, with thoughts on novel strategies to protect functional beta-cell mass.

258 ess the challenges unique to this age group, novel strategies to provide the best preoperative, intra

259 ds the RNA editing toolkit and illustrates a novel strategy for base editor optimization.

260 In this work, a novel strategy for the straightforward synthesis of subs

261 challenging NHP model, this study proposes a novel strategy to minimize the number of donor islets re

262 entral to this debate is whether wings are a novel structure on the body wall resulting from gene co-

263 We herein reported a series of novel substituted N-(4-amino-2-chlorophenyl)-5-chloro-2-

264 ing insights for the potential prediction of novel substrates by combining additional approaches.

265 NEVKP may represent a novel, superior preservation option for donation after c

266 exchanger, has recently been identified as a novel susceptibility gene for inflammatory bowel disease

267 ty and Nova-2 relocation were connected by a novel synapto-nuclear signaling pathway that surprisingl

268 ings highlight that CoV G-N-7 MTase may be a novel target for rational design of live attenuated vacc

269 uch as biantennary galactose could represent novel targets for selective manipulation of CD11b functi

270 eral computational framework for adapting to novel tasks based on their relationship to prior tasks.

271 es for stroke recognition, and deployment of novel technical solutions such as smartphone application

272 gmentation could represent a mechanistically novel therapeutic approach for the treatment of affectiv

273 with relapsed disease remains poor, and thus novel therapeutic approaches are needed.

274 ing pathways and they hold the potential for novel therapeutic approaches as well as a deeper underst

275 TPCs might represent a novel therapeutic target against HIV-1 infection and HIV

276 se asthmatic Th cells, identifying them as a novel therapeutic target for obesity-related asthma, a d

277 To identify the molecular mechanisms and novel therapeutic targets of late-onset Alzheimer's Dise

278 athophysiology with the potential to unravel novel therapeutic targets.

279 is remarkable process may help the design of novel therapeutics for neurodegeneration and other patho

280 n increasingly important asset in developing novel therapies for cancer.

281 Alongside efficacy testing of novel therapies, effects on pulmonary pathology and dise

282 These data point to a novel "thiol-blocked" [(PDT)Mo(V)O(S(Cys))(thiolate)](-)

283 , hyaline cartilage and perichondrium, for a novel tissue identity assay.

284 physiologically relevant conditions using a novel, to our knowledge, experimental methodology called

285 hermore, these subtypes were associated with novel, to our knowledge, susceptibility loci.

286 roteins and that they complement each other, novel tools that accurately identify the hard-to-predict

287 design and synthesis of molecular cages with novel topologies targeting a broad range of applications

288 resolution in situ hybridization to identify novel transcriptional regulators, we show that chromatin

289 guide future studies for the development of novel treatments for this disease.

290 on of mutations can be exploited to identify novel tumor suppressor genes and to obtain a deeper char

291 Fueled by the identification of novel ubiquitin and UBL sites and the characterization o

292 Herein, organic photodetectors based on a novel ultranarrow-bandgap nonfullerene acceptor, CO1-4Cl

293 Novel unprecedented helical foldamers have been effectiv

294 are not silent, are capable of transcribing novel unspliced forms of HIV-RNA transcripts with compet

295 gen structure and immunobiology is advancing novel vaccine candidates into human trials.

296 aries, thereby raising the discovery cost of novel vectors.

297 We demonstrate a novel viral gene expression strategy to target cells wit

298 monkeys received extensive training to learn novel visuospatial discriminations (reward-guided learni

299 Uncovering this link might open novel ways of treatment and prevention to improve patien

300 luable starting point for the development of novel wound-healing promoters.