ライフサイエンスコーパス: novel gene

1 mbined data repository analysis identified a novel gene.

2 ation identified four structural clusters of novel genes.

3 structure of gene networks, epigenetics, and novel genes.

4 e list of mouse imprinted genes including 18 novel genes.

5 rostin-expressing cells identified known and novel genes.

6 confirming the domain-specific expression of novel genes.

7 y 11,000 expressed genes and more than 2,100 novel genes.

8 tinct structures with a higher proportion of novel genes.

9 ies to influence the (long-term) survival of novel genes.

10 he level of lung function identified several novel genes.

11 Half were in novel genes.

12 d conserved promoters, splice junctions, and novel genes.

13 ntal cortex (P <= 9.43 x 10-6), including 20 novel genes.

14 approach, and the opportunity of uncovering novel genes.

15 olve by modifying existing genes or creating novel genes.

16 infected murine macrophages identified three novel gene 50 transcripts initiating from 2 transcriptio

17 Novel gene acquisitions include a gene for a putative ex

18 ildren aged 3 to 12 yr and nominated several novel genes: ACTN2, EDARADD, EPHA7, LPO, MPPED2, MTR, an

19 (Lcn2), and keratin 8 (Krt8)-and of several novel genes (Ahnak, Sh3bgrl3, and Col18a1) not previousl

20 Genome-wide screening identifies novel genes and biological processes implicated in cispl

21 Numerous novel genes and candidate biomarkers were upregulated du

22 our functional genomics analysis highlighted novel genes and critical pathways associated with kidney

23 sequence evolution as well as the origin of novel genes and functions contributing toward evolution

24 hnologies, such as metagenomics, to identify novel genes and gene transfer mechanisms.

25 The comparison with MneRV2 has revealed novel genes and important conservation of protein coding

26 Importantly, the large majority of novel genes and isoforms are supported by direct evidenc

27 ly improves genome annotation and identifies novel genes and isoforms in the rat.

28 xpression cues, tomo-seq can serve to reveal novel genes and key transcription factors involved in sp

29 alysis provides a reliable method to uncover novel genes and mechanisms related to phenotypes, althou

30 Exome sequencing discovered 2 novel genes and mechanisms, PDE4DIP and ACOT4, associate

31 d with oxidative stress, but also identified novel genes and metabolic pathways controlled by Spx dur

32 available datasets, and the method detected novel genes and network modules that were biologically p

33 Along with other novel genes and non-coding RNAs, a Parkinson's disease g

34 We are particularly interested in novel genes and observed multiple lines of supporting ev

35 These transcriptomes included novel genes and pathways associated with exposure to HCA

36 Novel genes and pathways can be identified using the gen

37 unsaturated fatty acids [PUFAs]) to identify novel genes and pathways involved in EtOH-associated gut

38 icant progress made in the identification of novel genes and pathways involved in the pathogenesis of

39 stems, constitutes a significant resource of novel genes and pathways with potential biotechnological

40 In summary, we report novel genes and rare variants that potentially play a ro

41 wever, larger samples are required to reveal novel genes and specific biological mechanisms.

42 ation studies often identify loci containing novel genes and there is a need to infer their functions

43 protocol plays a central role in identifying novel genes and transcripts as well as in studying gene

44 nd cost-effective tools for the discovery of novel genes and transcripts compared with expressed sequ

45 remain genetically unexplained, implicating novel genes and unrecognized mutations in known genes.

46 tic architecture has the potential to reveal novel genes and variants associated with traits and dise

47 ential pathologic ligand-receptor crosstalk, novel genes, and the improved injury response in younger

48 Correspondingly, young novel genes are not preferentially under positive select

49 Among those, the 10 identified novel genes are part of pathways of kidney development,

50 r, other modes have also been found, such as novel genes arising from non-coding DNA, chimeric fusion

51 Our analysis presents an array of novel genes as putative corneal stem cell markers.

52 This screen identified the novel genes as rv2799 and rv0966c as be necessary for fa

53 Importantly, we identified Pcsk6 as a novel gene associated with ASD via a human genotyping st

54 n airway inflammation and identify FHL2 as a novel gene associated with asthma severity in human.

55 A novel gene associated with nanophthalmos, TMEM98 most li

56 We identified 2 novel genes associated with an increased risk of ischemi

57 Our goal was to identify novel genes associated with atopy in asthma-ascertained

58 enetic variants and has revealed a number of novel genes associated with blood and other diseases.

59 informative samples enable the discovery of novel genes associated with cancer, the network of relat

60 rm an exome-wide search for rare variants in novel genes associated with CRP levels.

61 s a fundamental step toward the discovery of novel genes associated with human disorders, especially

62 quencing data and use this model to identify novel genes associated with important biological functio

63 We identified novel genes associated with NPC that point to new areas

64 We uncover many novel genes associated with PD but also novel mechanisms

65 l metabolizing genes and KLB, and identifies novel gene associations that should be the focus of futu

66 Novel gene-based associations were followed up in an ind

67 and (2) can be successfully prevented with a novel, gene-based approach.

68 This inquiry did not elucidate novel genes, but instead demonstrated that variants dist

69 e sought to fine-map known loci and identify novel genes by determining putative regulatory regions f

70 We validate gland cell expression in two novel genes by in situ hybridisation and catalogue dorsa

71 Novel genes can arise not only via duplication or mutati

72 Novel genes can be created, for example, by duplication

73 The novel gene candidates discovered in this study by genome

74 Together, our findings identify novel gene candidates involved in periodicity, and revea

75 at nano-LDHs have potential application as a novel gene carrier to plants.

76 ing models with genetic data, we developed a novel "gene-centric" model and compared model variants o

77 Here, we describe a novel gene (CG14141; aka Nkt) that is required for norma

78 B. longum SC596 contains a novel gene cluster devoted to the utilization of fucosyl

79 Further, we developed a novel gene cluster expression summary score (GCESS) to q

80 Each of the seven novel genes code for proteins associated with one or mor

81 y cell-type-specific induction of Thbs1 as a novel gene conferring high regenerative capacity.

82 d method could identify some significant and novel genes (containing no genome-wide significant SNPs

83 Identification of novel genes contributing to the NKD phenotype can also b

84 esults will facilitate the identification of novel genes controlling crop timing and quality traits i

85 sed a classical genetic approach to identify novel genes controlling nerve conduction.

86 omparative analysis showed that few of these novel genes could be discovered by other existing method

87 Among the novel genes discovered, WNT3, KANSL1, CRHR1, BOLA2, and

88 families; however, none of these represented novel gene discoveries.

89 uencing has demonstrated great potential for novel gene discovery, confirming disease-causing genes a

90 d tests and highlights the value of MTAR for novel gene discovery.

91 We identified 3 factors that limited novel gene discovery: (1) imperfect sequencing coverage

92 , use of international databases to identify novel gene-disease associations, and additional phenotyp

93 Here, we used a novel gene disruption strategy to generate the whole bod

94 Here we propose a novel gene drive mechanism that could be engineered usin

95 We introduce a novel gene-drive strategy termed Y-CHromosome deletion u

96 , also allows for extraction of reproducible novel gene-drug interaction signatures as well as accura

97 et serves as a valuable tool for identifying novel genes during plant anther and pollen development.

98 Our method identifies novel genes dysregulated in PTB and provides a generaliz

99 Thus, CRISPR/Cas9 technology represents a novel gene-editing strategy with compelling robustness,

100 transcript is an essential early step during novel gene emergence.

101 e the validity of a PRS and to demonstrate a novel gene-environment interaction, whereby the effect o

102 tive approaches can empower the discovery of novel gene-environment interactions and discuss specific

103 Thus the method is capable of predicting novel genes even for well-characterized diseases.

104 RNA-seq data identified several expected and novel gene expression changes associated with early drug

105 Additionally, a novel gene expression classifier, which identifies tumor

106 Application of novel gene expression classifiers identified two new DLB

107 A novel gene expression prediction method (called TFChrome

108 Our method integrates novel gene expression profiles from each major non-malig

109 Additionally, expression of a novel gene expression program involving sonic hedgehog (

110 n or survival of TAMs, but rather controls a novel gene expression signature associated with cytoskel

111 A novel gene expression signature identified severely inju

112 Novel gene families that are not well studied in other a

113 We identify many novel gene families that arose early in the evolution of

114 We identified a novel gene family, blitzschnell (bls), that consists of

115 Our results highlight DNAJC7 as a novel gene for ALS.

116 AS have been useful and continue to identify novel genes for allergic diseases through increased samp

117 CryptoNet effectively identified novel genes for pathogenicity and drug resistance using

118 However, the importance of novel genes for rapid adaptation among populations has r

119 ular network is an important way to identify novel genes for targeted therapeutics.

120 In an attempt to unravel novel genes for the persistence of ADHD into adulthood,

121 The classic model for the evolution of novel gene function is through gene duplication followed

122 es increased the sensitivity for associating novel gene function.

123 cular systems biology and for characterizing novel gene function.

124 quencing and RNA sequencing, we identified a novel gene fusion and demonstrated that it produces a ne

125 d of protein domain components arranged as a novel gene fusion architecture and of distant evolutiona

126 spitzoid tumor from an adolescent revealed a novel gene fusion of MAP3K8, encoding a serine-threonine

127 dentification of a rapidly growing number of novel gene fusions caused by tumour-specific chromosomal

128 s, while more recent advances have uncovered novel gene fusions involving neurotrophic tyrosine recep

129 ta to discover and subsequently PCR validate novel gene fusions missed by other algorithms in the ova

130 ranscriptomes occurs within 1 megabase of 78 novel gene fusions that function as central markers of t

131 As proof of principle that MACHETE discovers novel gene fusions with high accuracy in vivo, we mined

132 iltering, we identified a total of 13 (12/13 novel) gene fusions, 231 nonsynonymous single nucleotide

133 s and it provides reliable identification of novel gene-gene associations by utilizing prior biologic

134 This approach has the potential to identify novel genes/genomic regions linked to other polygenic di

135 synthase (LIAS), BolA type 3 (BOLA3), and a novel gene glutaredoxin 5 (GLRX5).

136 cs platforms for the rapid identification of novel genes governing pathogenicity and drug resistance

137 The findings of our study indicate that a novel gene has evolved in guinea pigs through fusion of

138 ERE NEXT?: The identification of these seven novel genes has been important in unravelling the molecu

139 However, the effects of these novel genes have not yet been investigated in animal mod

140 ent signal in this region, and SNPs near two novel genes: HDGFL1 on chromosome 6 and MAF on chromosom

141 We identified an orphan GPCR, Gprc5b, as a novel gene highly enriched in podocytes that was signifi

142 Three novel genes, HOXA4, KLK1, and TIMM23, additionally repli

143 arative genomics is a powerful technique for novel gene identification/prioritization.

144 Novel genes identified as being sensitive to triclosan e

145 cated at novel SNPs, and 3 of 33 (9.1%) were novel genes identified with gene-based analysis.

146 We also detected associations in three novel genes: IGHG3 (p = 9.8 x 10(-7)), an immunoglobulin

147 dentify functionally and clinically relevant novel genes implicated in LFS.

148 Novel genes important at distinct stages of the meiotic

149 y transposon (Tn) mutant library to identify novel genes important for E. faecalis colonization and p

150 opmental disease, including the emergence of novel genes important in human brain evolution.

151 Our study establishes SCN8A as a novel gene in which a recurrent mutation causes BFIS/ICC

152 ers to exploit genome-wide datasets to infer novel genes in any biological function and to explore de

153 To identify novel genes in familial KC patients, we performed whole

154 We implicate novel genes in fat distribution, stressing the importanc

155 ions in the vast noncoding genome, uncovered novel genes in localized prostate cancer, and will foste

156 is further supported by the large number of novel genes in the complete and partial genomes showing

157 Using the chick embryo, we uncover novel genes in the gene regulatory network underlying ot

158 These data provide supportive evidence for novel genes in the pathogenesis of CDH associated with o

159 Many novel genes, including ACSM2A/2B, FAM47E, and PLXDC1, we

160 ns in the expression of well-established and novel genes, including an inverse association between NT

161 Here, we present the application of a novel, gene-independent and signature-based metagenomic

162 HGT likely contributed to the creation of a novel gene indispensable for reproduction in some insect

163 In summary, we have identified several novel genes influencing the major clinical risk predicto

164 study, we applied this strategy to identify novel gene interactions in KRAS-mutant cancer cells.

165 h biological properties, outlining known and novel gene interactions.

166 These findings thus describe a novel gene involved in cellular lipid homeostasis, which

167 Collectively, our results identify Ppid as a novel gene involved in regulating extinction via functio

168 ur findings suggest that PMVK is a potential novel gene involved in the pathogenesis of DSP and PMVK

169 RISPR-Cas9 screen to systematically identify novel genes involved in APAP-induced hepatotoxicity and

170 dinate during the M/E switch and to identify novel genes involved in follicle cell differentiation, w

171 Novel genes involved in secondary metabolism, including

172 To identify novel genes involved in seed Fe homeostasis, we screened

173 We can perform genetic screens to identify novel genes involved in specific disease processes and c

174 ggesting that the other 28 genes were likely novel genes involved in the mood disturbance mechanism.

175 ssisted predictions can effectively identify novel genes involved in virulence and antibiotic resista

176 Taken together, expression of the surviving novel genes is rapidly regulated, probably via epigeneti

177 Among a number of novel genes, isocitrate dehydrogenase (IDH) is recurrent

178 ype III RNA-targeting CRISPR-Cas system as a novel gene knockdown platform to investigate gene functi

179 We present GenePy, a novel gene-level scoring system for integration and anal

180 In summary, we present WDFY3 as a novel gene linked to mild to moderate neurodevelopmental

181 We identify 6 novel gene loci for height, 2 for BMI, and 3 for schizop

182 isoforms of known genes and 3% correspond to novel gene loci.

183 itional polymorphic markers, we identified a novel gene locus on chromosome 3q in this PRRT2-mutation

184 set of opportunities for the colonization of novel genes manifesting weakly advantageous or even tran

185 We characterize known and novel gene markers for ~800 clusters and provide an over

186 ne expression analysis performed to identify novel gene modulations associated with cell cycle dysreg

187 ecific gene expression markers, as well as a novel gene module whose overexpression in blood endothel

188 The analysis revealed known and novel gene modules regulated by the NF-Y motif.

189 rentially under positive selection but older novel genes more often overlap with F(ST) outlier region

190 urate, fast, and can identify both known and novel gene mutations.

191 Our genome-wide analyses identified one novel gene (NDUFB9) associated with the genetic predispo

192 to how the probiotic interacts to regulate a novel gene network involved in glucose metabolism and ap

193 dulation of the gut microbiome, highlights a novel gene network involved in lipid metabolism, provide

194 Our novel gene network provides a unique and comprehensive r

195 We first constructed a novel gene network via a pairwise comparison of all yeas

196 ed with bioinformatics pipelines to identify novel gene networks regulated by particular epigenetic m

197 eover, bioinformatic analysis identified two novel gene networks that may underlie normal MEC functio

198 ady known serum resistance factors, and many novel genes not previously associated with serum resista

199 Our transcriptome analysis reveals several novel genes not previously described in microglia.

200 Our analysis identifies novel genes not previously implicated in schizophrenia a

201 d invasion in 3D by inducing expression of a novel gene of interest, glycoprotein nonmetastatic B (GP

202 genetically predicted gene expression in 687 novel genes; of these, 54 are known to interact with FDA

203 ng signal detection power via uncovering (a) novel genes or (b) known associated genes in smaller coh

204 itness, possibly associated with the gain of novel genes or mutations.

205 nic transcription represents the activity of novel genes or noisy expression.

206 ccelerate the determination of causality for novel genes or variants.

207 Here, we describe a novel gene, OSTL (annotated as RNF217 in Genbank), which

208 e automated methodology for the discovery of novel genes, pathways and experimental phenotypes.

209 levels (P-value < 4.2 x 10-10), including 16 novel gene-peptide pairs.

210 In addition, we identified 18 significant novel gene-phenotype associations in our ancestry-specif

211 cross three ancestry groups, resulting in 20 novel gene-phenotype associations reaching experiment-wi

212 f the mutational landscape of ATC identifies novel genes potentially associated with ATC tumorigenesi

213 , allowing a more facile characterization of novel gene products and subcellular complexes.

214 agenesis study and growth studies to confirm novel gene products required for XoxF1 function.

215 Each of the novel genes provided here are potentially relevant to th

216 The identification of this novel gene provides a wider role for the inhibitor of ap

217 covery rate (FDR) </=0.05 were mapped to one novel gene PRPF6 and two previously reported genes (DHX1

218 We further identified a number of novel genes recurrently mutated in patients with MCL inc

219 The findings identify Vegfb as a novel gene regulated by the PGC-1alpha/ERR-alpha signali

220 ale interaction data can predict function of novel genes regulating development.

221 ay lead to their induction, and describe how novel gene regulatory and immune-related functions of th

222 Taken together, our results demonstrate a novel gene-regulatory mechanism in which HCV-induced cha

223 ideal testing ground for the development of novel gene replacement, gene editing, and cell replaceme

224 The novel genes reported here may implicate molecular pathwa

225 age-specific genes are often interpreted as "novel" genes, representing genetic novelty born anew wit

226 rtebrae following genome duplication, when a novel gene repressed ancestral spine programming.

227 ggesting that NL-association may represent a novel gene repression pathway.

228 Forced expression of these novel genes resulted in IL3-independent growth in vitro

229 disease subsets is important for identifying novel genes, risk stratification and potential clinical

230 The novel gene sets are indeed more correlated than the conv

231 Novel gene sets defined on the basis of regulatory inter

232 Analysis of individual variants identified a novel gene-sex interaction at locus 21q22.11.

233 Because these novel genes share common disease pathways with other gen

234 Here we present xCell, a novel gene signature-based method, and use it to infer 6

235 This paper shows that two novel genes, Sly and Asty are also present on mouse Yq a

236 We identified novel gene-smoking interaction for a variant upstream of

237 ost studies on the gain-and-loss dynamics of novel genes so far have compared genomes between species

238 indings thus establish miRNA regulation as a novel gene-specific dosage compensation mechanism.

239 Kap1 and Vrs1, respectively, whereas B is a novel gene specifically controlling awn development on L

240 We demonstrate here a novel gene stacking strategy by combining bidirectional

241 utions of alternative splicing in generating novel gene structures.

242 atic and the dynamic networks, we identified novel genes (such as OSBP2 and PDZK1IP1) that are potent

243 ng-Induced Paralysis (Swip), we identified a novel gene, swip-10, the expression of which in glia is

244 We therefore establish Fgf21 as a novel gene target of Fenretinide signalling via a retino

245 tify mechanisms of degeneration, and provide novel gene targets for therapeutic interventions.

246 dation with CRISPR-Cas9-induced mutations in novel genes Tead2, Spred1, and Nav3 demonstrates heighte

247 Another novel gene, TEAD2, is found to be associated with high-d

248 Our data identifies ADAMTS3 as a novel gene that can be mutated in individuals affected b

249 yos, as it does in humans; and highlighted a novel gene that plays a role in HRV (KIAA1755).

250 gene-9 (MDA-9), also known as syntenin, is a novel gene that positively regulates cancer cell motilit

251 Among these, we identified Bbox1 as a novel gene that specifically labels all neurons in the g

252 veral cell lineages revealing both known and novel genes that are expressed along a developmental tra

253 Recent studies in zebrafish have revealed novel genes that are required for HSC induction and nich

254 otation of a complete repertoire of thirteen novel genes that belong to the L1L paralogous gene famil

255 This study aimed to identify novel genes that cause familial Parkinson's disease.

256 y of fast neutron mutagenesis in identifying novel genes that contribute to soybean agronomic traits.

257 creened >10,000 blood samples and discovered novel genes that contribute to vertebrate genome mainten

258 ssential genes in mES cells, and to identify novel genes that control sprouting angiogenesis and line

259 mplicated in other human cancers, as well as novel genes that could allow new therapeutic options.

260 ng a Bayesian hierarchical model to identify novel genes that could potentially influence the pathway

261 cancer genomes and enabled the discovery of novel genes that drive and maintain tumorigenesis.

262 Here we present novel genes that may be causative for oculocutaneous dis

263 s provide new candidate genes for ataxias or novel genes that may be critical for cerebellar function

264 usual gene origin processes can give rise to novel genes that may facilitate evolution of novel devel

265 ng non-coding RNAs (lncRNAs) are a family of novel genes that regulate gene transcription and transla

266 cellularization and proliferation as well as novel genes that will be useful candidates for biotechno

267 We developed a novel gene therapy approach based on the use of the pigg

268 Using a highly novel gene therapy approach in a canine, rapid atrial pa

269 this system to demonstrate the effects of a novel gene therapy approach in human heart slices.

270 This novel gene therapy approach opens the prospect of NIS-me

271 promising strategy for the development of a novel gene therapy approach.

272 Herein we report a novel gene therapy delivery approach, suprachoroidal inj

273 ion that could provide potential targets for novel gene therapy.

274 As such, the miR-106b-25 cluster could be a novel gene-therapy target in AF associated with enhanced

275 assical candidate gene identification, links novel genes to IBD and can be applied to any existing GW

276 odels of 352 genes, including identifying 20 novel gene transcripts.

277 reviously reported in related disorders, and novel genes TRIP12 and PAX5.

278 Our findings suggest that novel genes typically start out as transcripts with low

279 In particular, we identify Abcc6 as a novel gene underlying a fibrosis locus by validating tha

280 To discover novel genes underlying amyotrophic lateral sclerosis (AL

281 sed this technique in an attempt to identify novel genes underlying monogenic dyslipidemias.

282 study also provides a framework to identify novel genes using comparative transcriptomic data to imp

283 phic lateral sclerosis (ALS) have implicated novel genes using gene-based collapsing methods.

284 e clinic and laboratory for the discovery of novel gene variants.

285 Among the novel genes, we find a viral-like mobile element, the te

286 Novel genes were confirmed by functional studies in the

287 s (e.g., CDYL2, MST1R, GPER1, and PARD3B), 3 novel genes were identified (FDR q < 0.05), including th

288 Several novel genes were identified with high weighted connectiv

289 e was improved in over 13% of genes, and 651 novel genes were predicted by the GC-specific MAKER prot

290 MHC-II genes and a few novel genes were regulated by CIITA; however, most other

291 Our results highlight a novel gene which regulates coffee consumption by regulat

292 1, TRIO, IRAK1, PNCK, and TAOK1 as potential novel genes whose knockdown induces various mitotic abno

293 ressive lymphoma cells and define NR4A1 as a novel gene with tumor suppressor properties involved in

294 Long considered a novel gene with unknown origin, oskar has evolved to ful

295 o-location and shared biological function of novel genes with genes known to associate with a specifi

296 Many novel genes with poorly defined functions were also diff

297 of the differentially methylated genes were novel genes with respect to biological effects of smokin

298 This study identified novel genes within the neuronal projection guidance path

299 sion shuffles the TFAP2A hNCC enhancers with novel genes within the same TAD, this does not result in

300 er, this is not a feasible option where many novel genes, without pre-existing models, would need to