ライフサイエンスコーパス: novel protein

1 id sequence ATTQWKTSAA and confirmed HM-3A a novel protein.

2 structure-function relationships and create novel proteins.

3 nt in evaluating the sensitizing capacity of novel proteins.

4 f Syn5 includes a number of genes coding for novel proteins.

5 plex morphologies without the acquisition of novel proteins.

6 ned thus far, lin-8 and lin-15A, both encode novel proteins.

7 asome co-purifying proteins, as well as some novel proteins.

8 n function correlates with immunogenicity of novel proteins.

9 tive enzymes, and other effectors, including novel proteins.

10 , corresponding to 29 known allergens and 61 novel proteins.

11 A novel protein, 14-3-3GF14f was observed to be upregulate

12 SPR measurements with use of a novel, protein A-based sandwich system for the immobiliz

13 generating samples suitable for detection of novel protein adducts (e.g. by mass spectroscopy).

14 r AD-related proteins and revealing numerous novel protein alterations enriched in the pathways of am

15 nable the efficient preparation of large and novel protein analogues.

16 i defective genes rde-10 and rde-11 encode a novel protein and a RING-type zinc finger domain protein

17 to infer their biological consequence (i.e. novel protein and increased gene expression).

18 proteins, as well as the potential roles of novel proteins and MAPKs in the polarity establishment r

19 er validated candidates will likely identify novel proteins and mechanisms by which TRIM9 and TRIM67

20 ucts encoding rcdBB, mmsdh, RMD1, actin, one novel protein, and a 14-3-3 hairpin.

21 bind to host RNA polymerase (RNAP): gp79, a novel protein, and gp36, a distant homolog of sigma(70)

22 Among these novel proteins are three mammalian rRNA methyltransferas

23 have inspired synthetic biologists to create novel protein assemblies via the precise manipulation of

24 Our results show that TsaP is a novel protein associated with T4P function and suggest t

25 We identified 332 known and 114 novel proteins associated with these histone-marked geno

26 alysis, fluorescent protein fusions revealed novel proteins at organelle interfaces such as plastid s

27 Novel protein-based antifibrotic drugs show high specifi

28 highly conserved OLF domain, and suggests a novel protein-based hypothesis for glaucoma pathogenesis

29 sed inactivated influenza virus vaccines and novel protein-based vaccines.

30 This novel, protein-based electrochemical sensing architectur

31 ing various approaches, we have identified a novel protein, BB0326, as a key component of the collar.

32 s and are essential to identify and validate novel protein binding partners.

33 Novel protein biomarker models improve identification of

34 Identification of novel protein biomarkers has been limited due to the mas

35 To identify novel protein biomarkers in stool that outperform or com

36 lational efforts, including the discovery of novel protein biomarkers of disease.

37 To identify novel protein biomarkers of prostate cancer risk, we stu

38 result in a +1-bp frameshift and generate a novel protein C terminus.

39 imental optimization were used to generate a novel protein called BINDI that binds BHRF1 with picomol

40 We report a novel protein, Callipygian (CynA), which localizes to th

41 uence of the amino acid substitutions in the novel protein candidates for direct input into epitope e

42 Previously, we described a novel protein, catabolite control protein E (CcpE) that

43 o assist in drug discovery and the design of novel protein catalysts.

44 nding of enzyme mechanisms and for design of novel protein catalysts.

45 In this work, we identify a small novel protein, CCS4, as a third component in this pathwa

46 Our study identifies several novel protein changes in Parkinson's disease cerebrospin

47 discovery and intracellular location of six novel proteins (cingulins) that are integral components

48 t the association of this network with three novel protein clusters involved in cell wall biogenesis,

49 enome contains a rich resource of shared and novel protein coding genes, a significantly higher amoun

50 ing annotation errors and identify potential novel protein coding regions and sRNA.

51 olution map enabled the identification of 14 novel protein coding regions as well as 44 potential nov

52 orly differentiated CRC cells, we identified novel protein-coding and lncRNA genes regulated by FOXA1

53 of transcripts from RNA-sequencing revealed novel protein-coding and long noncoding RNAs (lncRNAs).

54 ur results highlight already established and novel protein-coding and non-coding ceRNAs which could s

55 Collectively, our results uncover novel protein-coding and noncoding targets of FOXA1 and

56 We also report a novel protein-coding gene evolution-D6Ertd527e-in which

57 ong non-coding (lnc) RNA genes and part of a novel protein-coding gene.

58 Evidence has been found supporting 16 novel protein-coding genes being added to GENCODE.

59 Recent evidence demonstrates that novel protein-coding genes can arise de novo from non-ge

60 Novel protein-coding genes can arise either through re-o

61 Mb novel genomic sequences and at least 188 novel protein-coding genes missing in the human referenc

62 Altogether, we identified 635 novel protein-coding genes, 508 novel transcribed region

63 prised 28,294 expressed, annotated genes, 78 novel protein-coding genes, and 567 putative long interg

64 analysis enabled us to discover a number of novel protein-coding regions, which includes translated

65 er rigorous data filtering, 51 (presumptive) novel protein-coding transcripts, 5326 long and 679 smal

66 Here we identified novel protein-coding UPF2 (UP-Frameshift 2) variants in

67 We developed a novel protein complementation assay allowing quantificat

68 In conclusion, we describe a novel protein complex between ficolin-2 and ficolin-3 pr

69 We identified a novel protein complex containing the spine regulator Rac

70 Here we show that WTAP forms a novel protein complex including Hakai, Virilizer homolog

71 the yeast PKM2 homolog, Pyk1, is a part of a novel protein complex named SESAME (Serine-responsive SA

72 ere, we demonstrate that RAD51C is part of a novel protein complex that contains PALB2 and BRCA2.

73 phosphorylation patterns of BCAP and used a novel protein complex trapping strategy, called virotrap

74 ite stages of Plasmodium and it is part of a novel protein complex with an overall composition overla

75 ced silencing-defective 1), we here define a novel protein complex, PETISCO (PID-3, ERH-2, TOFU-6, an

76 lear mRNPs and DBC1 (ZIRD)) as subunits of a novel protein complex--named DBIRD--that binds directly

77 btain realistic estimates, we introduced two novel protein complex-aware cross-validation schemes.

78 lts presented here identify and validate two novel protein components of the putative tRNA translocon

79 Statin therapy downregulated novel proteins concerned with the modulation of pancreat

80 eating therapeutic conjugates and generating novel protein constructs.

81 , we have now identified and characterized a novel protein contact between the Y-family DNA polymeras

82 Seven of the novel proteins contain 7.5% or more of lysine mass, just

83 Novel protein crystallographic structures of the prototy

84 culminating in the discovery of CC-92480, a novel protein degrader and the first CELMoD to enter cli

85 In this study, we demonstrate a novel protein delivery method via encapsulating therapeu

86 A novel protein delivery platform has been created by comb

87 y unknown RNA segment (segment 7) encoding a novel protein designated VP7 was discovered in WFBV.

88 disA-1 abolishes the localization of the novel protein DisAp to T. thermophila striated fibers (k

89 uss a comprehensive overview on Nischarin, a novel protein discovered by our laboratory.

90 These novel proteins distinguish Lh from Lb VLPs; notably, som

91 tor inhibitor-1 (PAI-1) gene that recruits a novel protein-DNA complex responsible for TCDD-inducible

92 m GM12878 and K562 cells and identified many novel protein-DNA interactions in segmental duplication

93 We present a novel protein docking algorithm that utilizes imperfect

94 Thus, Tg appears to be a novel protein elaborated as a single event at the base o

95 The novel proteins elucidated in this work may provide new i

96 PA-X is a novel protein encoded by PA mRNA and is found to decreas

97 Among over 100 novel proteins enriched at a DSB were the phosphatase Si

98 The novel proteins exhibit significant selective constraint

99 Here, we developed a novel protein extraction method that does not use demine

100 er take place between 8-10 h of IVF, and the novel protein failed to inhibit G9a activity in time, re

101 us proteins help in functional annotation of novel protein families and in improving annotations of w

102 and draft genomes reveal a 10.5% increase in novel protein families as a function of phylogenetic div

103 al complexity enables us to rapidly identify novel protein families found in new genomes and to perfo

104 rminal domain of wild-type TnsE identified a novel protein fold including a central V-shaped loop tha

105 The first C-terminal domain D5 forms a novel protein fold of a four-stranded antiparallel beta-

106 73-NTD at 1.02 A resolution, which reveals a novel protein fold.

107 assesses methods on their ability to predict novel protein folds (the Zhang group placed first in the

108 The ability to engineer novel protein folds, conformations, and enzymatic activi

109 o determine the mechanistic function of this novel protein for vaccine or inhibitor development.

110 with symbiosis, immunity, and addiction; and novel proteins for membrane abscission and protein turno

111 randomly selected and deleted, revealing two novel proteins, FTL_1548 and FTL_1709, which are require

112 ajectories during the ancient evolution of a novel protein function.

113 t LNA and GNA in the application of learning novel protein functional knowledge, the two produce very

114 First, it computes our novel protein functional similarity scores by fusing inf

115 proteins can be helpful in understanding how novel protein functional sites evolved on an ancient pro

116 roteolysis by calpains potentially generates novel protein functions, it is important to understand h

117 Casp8p41, a novel protein generated when HIV-1 protease cleaves casp

118 ession of the cell-cycle inhibitor p16 and a novel protein homologous to Scp3, a synaptonemal complex

119 e Electrophile Response Element (EpRE) and a novel protein, human homolog of Xenopus gene which Preve

120 Depletion of three of these novel proteins, i.e. TbTim47, TbTim54, and TbTim62, sign

121 We report a novel protein immobilization matrix for fully integrated

122 Recently in our laboratory, we identified a novel protein in C. elegans involved in dietary choleste

123 This approach allowed the identification of novel proteins in E. oleoabundans, including two photopr

124 resent in a unique TIM complex consisting of novel proteins in T. brucei and is critical for mitochon

125 ially, we demonstrated for a subset of these novel proteins (including cullin1, ephexin, potassium ch

126 dition to Ago2 and PCBP2, identified several novel proteins, including IGF2BP1, hnRNP L, DHX9, ADAR1,

127 works present at the glial-leading edge, and novel proteins, including members of the Prohibitin fami

128 nd in authentic LBs in PD as well as several novel proteins, including the microtubule affinity-regul

129 Using this module, we developed a novel protein interaction assay, Light-Induced Co-cluste

130 In this study, we discovered a novel protein interaction between the glucocorticoid rec

131 roxyanilino)methylidene]naphthalen-2-one), a novel protein interaction inhibitor of replication prote

132 A new study has revealed a novel protein interaction linking microtubule plus-ends

133 ss of complex formation, thus validating the novel protein interaction mode in the 14-3-3beta.ChREBP

134 These results identify a novel protein interaction that links matrix degradation

135 These findings identify novel protein interactions involving CLEC14A, CD93 and C

136 -tune binding specificities or change/create novel protein interactions is a common task in structure

137 Novel protein interactions suggest a highly complicated

138 ion plays in promoting signal amplification, novel protein interactions, and protein turnover has pro

139 to protein complexes and pathways, and finds novel protein interactions, even within well-characteriz

140 or genome-wide PPI studies and has uncovered novel protein interactions, providing new insight into p

141 e for identifying transient and surprisingly novel protein interactions.

142 proteins we identified Matrin 3 (MATR3) as a novel protein interactor of PABPN1.

143 ating Wnt signalling and identify Axin1 as a novel protein interactor of the widely-expressed gamma-P

144 identify RV proteins in sIBM that included a novel protein involved in sIBM pathogenesis.

145 2A), through a yeast two-hybrid system, as a novel protein involved in the stabilization of VEGFR-2 b

146 Here we sought to identify novel proteins involved in IL-1beta secretion and intrac

147 the evolutionary path from ancestral gene to novel protein is challenging to trace, and therefore the

148 Here we show that TbTim62, a novel protein, is localized in the mitochondrial inner m

149 generated from human SMN genes and reveals a novel protein isoform predicted to be stably expressed d

150 The identification of novel protein isoforms derived from alternatively splice

151 oforms of CCM2 which eventually generated 22 novel protein isoforms.

152 H2Av are anchored to lipid droplets via the novel protein Jabba [3].

153 ication, and mass spectrometry to identify a novel protein, KHARON1 (KH1), which is important for the

154 Here, we demonstrate that classical and novel protein kinase C (PKC) isoforms distinctly regulat

155 cerol (DAG) content leading to activation of novel protein kinase C (PKC) resulting in decreased insu

156 hodology allows the development of potential novel protein kinase C delta (PKCdelta) analogues for be

157 Here we report that PKCtheta, a novel protein kinase C, down-regulates GIV's GEF functio

158 Therefore, to identify novel protein kinase G substrates in vascular cells, a l

159 on detection for the rapid identification of novel protein kinase inhibitors.

160 n two steps, with the second step defining a novel protein kinase regulatory mechanism.

161 onal RNA interference-based screen linked 30 novel protein kinases with ciliogenesis.

162 Functional annotation of novel proteins lags behind the number of sequences disco

163 whether these databases are good sources of novel protein ligands and how many molecules are obtaina

164 ning 160,000 compounds is a useful source of novel protein ligands by identifying a non-covalent synt

165 nsional structures, and ultimately to design novel protein-like architectures with properties unprece

166 generated by these cells identified multiple novel proteins linked to metastasis.

167 me in a validated iPSC SMC model to identify novel protein markers associated with MFS aneurysm pheno

168 ces between each monocyte subset to identify novel protein markers.

169 in orb spiders, coupled with the origin of a novel protein (MaSp2).

170 microbiota antigens was assessed by using a novel protein microarray.

171 Discovery of this novel protein modifier raised the possibility that the 4

172 n's C-terminal domain binds lipids through a novel protein motif, permitting complexin to inhibit spo

173 ken together our data show that METTL15 is a novel protein necessary for efficient translation in hum

174 e show that root gravitropism depends on the novel protein, NEGATIVE GRAVITROPIC RESPONSE OF ROOTS (N

175 texture were elucidated and quantified by a novel protein network analysis.

176 Collectively, these data reveal a novel protein network operating in the neural crest-deri

177 In this study, we identify a novel protein, NOP-1, that functions in parallel with CY

178 as IP-10, LBP, FCG3B, and TSP4, and for many novel proteins not previously associated with TB.

179 In addition, we also identified 12 novel proteins, not previously known to be physiological

180 ity of the approach in validating completely novel proteins, novel splice junctions, and single amino

181 ew Clr6 HDAC complex, I'', delineated by the novel proteins Nts1, Mug165, and Png3.

182 In this study, we demonstrate that Tda2 is a novel protein of the endocytic machinery necessary for n

183 ve reported previously the identification of novel proteins of Mycobacterium tuberculosis by the immu

184 draft H. bacteriophora genome sequence were novel proteins of unknown function lacking homologs in C

185 amina analogue NUP-1, represents a cohort of novel proteins operating at the nuclear periphery of try

186 gulated in spinal cords of ALS patients, the novel protein oxidative resistance 1 (Oxr1) protects neu

187 A novel protein, OZONE-RESPONSIVE APOPLASTIC PROTEIN1 (OsO

188 A novel protein, p18, anchors to the endosome membrane and

189 We have identified a novel protein partner called Hp0100 as a component of a

190 ly, our data suggest XRN2's association with novel protein partners and unravel synthetic lethality b

191 We identified a novel protein, POLAR, and demonstrate through time-lapse

192 The aim of this study was to test a novel protein polymer-based platform consisting of diblo

193 might exhibit phase behaviour and to design novel protein polymers consisting of biologically active

194 This work provides new insights into the novel protein-primed mechanism of calicivirus VPg-depend

195 In this study, we describe a novel protein production platform that provides both act

196 potential resistance traits that involve no novel protein production.

197 abeled antibodies, we show that two of these novel proteins, products of genes 53 and 54, are part of

198 To identify novel proteins promoting the final maturation of human 4

199 We identify a novel protein-protein interaction between Sam68 and AR-V

200 This effect is mediated by a novel protein-protein interaction between VP35 and NP th

201 es of the PRL-1.Peptide 1 complex revealed a novel protein-protein interaction whereby a sequence mot

202 ding domain of p53; and (iv) it stimulates a novel protein-protein interaction with the E2-ubiquitin

203 ic binding partners for PRRG4 and identified novel protein-protein interactions for the protein.

204 These results provide new evidence for novel protein-protein interactions on ECs that may contr

205 nelle and its surface as the active site for novel protein-protein interactions.

206 Computation-based design of novel protein-protein interfaces can serve as a bottom-u

207 Computational design of novel protein-protein interfaces is a test of our unders

208 Here we demonstrate that a novel protein/protein interaction between blood vessel e

209 Thus, this study characterizes a novel protein/protein interaction domain disrupted in a

210 Raf and PI3K, as well as a common set of 130 novel proteins proximal to all Ras isoforms.

211 Here we report the design of a novel protein, PS1, that binds a highly electron-deficie

212 nvelope membrane where it possibly confers a novel protein quality control mechanism for chloroplast

213 In the present study, we aimed to identify novel protein receptor targets for TCDD using computatio

214 differentiation-related factor 1 (EDF1) as a novel protein recruited to collided ribosomes during tra

215 A recently discovered novel protein, referred as neuroendocrine marker (NEM),

216 Overall, our studies reveal a novel protein-regulated PTR event in a vertebrate system

217 tional pre-mRNA splicing factor, WBP11, as a novel protein required for centriole duplication.

218 Here, we identify a novel protein required for paramutation at the maize pur

219 g the utility of this dataset in identifying novel proteins required for desmosome-dependent epiderma

220 To discover novel proteins required for these processes, we used bio

221 The novel proteins rKR95 and rTR18 possessed the greatest po

222 CLAM provides a useful tool to discover novel protein-RNA interactions and RNA modification site

223 ction of the Rho-GAP Rga7 are regulated by a novel protein, Rng10, during cytokinesis in fission yeas

224 ition of G9a activity depends on yet unknown novel protein(s) synthesis.

225 (18)F-FBEM-Cys-Z(EGFR:1907) is a novel protein scaffold-based PET probe for imaging EGFR

226 Recently, a novel protein secretion system, the Por secretion system

227 A novel protein secretion system, the type IX secretion sy

228 A novel protein secretion system, the type IX secretion sy

229 r crystal structure determination to explore novel protein sequence space and structure-based functio

230 n for structure-based function annotation of novel protein sequence space.

231 ripts, potentially capable of producing long novel protein sequences and a plethora of neoantigens.

232 ments have contributed to the acquisition of novel protein sequences during primate and human evoluti

233 ify new genomic alterations that may lead to novel protein sequences, which are attractive candidates

234 n sequence annotation pipeline for analysing novel protein sequences.

235 uencing, thus enabling the identification of novel protein sequences.

236 We have identified a novel protein, SHORT-ROOT INTERACTING EMBRYONIC LETHAL (

237 hat Skb1 forms nodes by interacting with the novel protein Slf1, which is a limiting factor for node

238 ed sugar specificity in contemporary BCoV or novel protein specificity in contemporary MHV.

239 of this CHIP-SirT6 interaction represents a novel protein-stabilizing mechanism and defines an inter

240 protein extensions, 231 exon extensions, 192 novel protein start sites, 19 novel translational frames

241 effective tool for engineering and design of novel protein structures (including naturally knotted pr

242 Here, we build novel protein structures by extending naturally occurrin

243 demonstrates the feasibility of determining novel protein structures using FELs.

244 Our studies identify a novel protein substrate for PTEN that couples PTEN to re

245 in brain (Rheb), an activator of mTOR, as a novel protein substrate of Sel1L/Hrd1 ERAD, which accumu

246 entified several previously known as well as novel protein substrates.

247 ses, defense against radiation injuries, and novel proteins such as ZBP-89.

248 In this study, a novel protein tagging technology was used to localize th

249 of drug-dependent plasticity and uncovering novel protein targets in the reward circuit may lead to

250 lso investigated the possible mechanisms and novel protein targets involved in rapamycin-induced pres

251 orm is envisioned to be widely applicable to novel protein targets, identifying starting points in th

252 ion of the 6K gene, yielding production of a novel protein, termed transframe (TF), comprised of a C-

253 The sao-1 gene encodes a novel protein that contains a GYF protein-protein intera

254 ese collective findings identify DEPTOR as a novel protein that functions in CD4(+) T cells to augmen

255 vides fundamental structural insights into a novel protein that has undergone multiple biochemical an

256 Collectively, this work identifies a novel protein that plays a role in the assembly of the m

257 continuous alpha-helical linker to design a novel protein that self assembles into a 750 kDa, 225 A

258 synMuv gene lin-56 and found it to encode a novel protein that shares a THAP-like C(2)CH motif with

259 These specific proteins include a novel protein that we term radular teeth matrix protein1

260 slation from antisense CCG repeats generates novel proteins that accumulate in ubiquitinated inclusio

261 e, we used a systematic approach to identify novel proteins that are involved in cancerous EGFR signa

262 rs of this stomatal transcription factor and novel proteins that could facilitate its activator and r

263 We have previously identified 7 novel proteins that could improve serodiagnosis.

264 Designing and producing novel proteins that fold into stable structures and prov

265 biochemical insights into IRES function and novel proteins that function as alternate met-tRNA(i)(me

266 e RNA interference (RNAi) screen to discover novel proteins that function in the replication stress r

267 nity purification and LC-MS/MS to search for novel proteins that interact with R7-RGS heterotrimers i

268 Characterizing novel proteins that offer crucial insights into the proc

269 We found known and novel proteins that warrant further studies for developi

270 r 70% of the tested compounds and elucidated novel proteins that were experimentally validated.

271 We demonstrate that CG42630 encodes a novel protein, the coiled coil domain-containing protein

272 A third novel protein, the product of gene 58, is assembled onto

273 A novel protein, Themis, is important in crossing the posi

274 ved growth factor fragment (LEDGF1-326) as a novel protein therapeutic.

275 This is critical for designing and screening novel protein therapeutics and for understanding their p

276 Novel protein therapeutics have become increasingly impo

277 gh understanding of the biotransformation of novel protein therapeutics.

278 t the idea that Laminin-111 could serve as a novel protein therapy for the treatment of DMD.

279 We present a novel protein threading method, CNFpred, which achieves

280 The present study delineates a number of novel proteins, TLR3-related pathways, and cellular phen

281 the airways of adults with COPD to identify novel proteins to investigate their role in adherence an

282 PETISCO is mediated not by PID-1 but by the novel protein TOST-1 (twenty-one U pathway antagonist).

283 powerful ChIP-MS technique and discovered a novel protein, TRIM24, enriched on OCT4-, SOX2-, and NAN

284 in two affected individuals we identified a novel protein-truncating mutation in the C12orf65 gene,

285 In this study, we identify eight novel protein-truncating variants, six de novo, in 13 pa

286 The novel protein tyrosine phosphatase PTPN14 was identified

287 Deep sequencing of CMG0 and CMG28 revealed novel protein variants in the hypothetical genes TC0237

288 ased on these novel transcripts, at least 36 novel proteins were detected from shotgun proteomics dat

289 GABA receptor subunits and gephyrin, several novel proteins were isolated in association with NL2.

290 ediated transcription, suggesting that these novel proteins were putative SBP-AR-interacting proteins

291 T cell targets for both known allergens and novel proteins, which may inform future diagnostics and

292 The novel protein will address the insufficient release of n

293 We identify PPIA as a novel protein with levels that are decreased in clinical

294 NdmD itself is a novel protein with one Rieske [2Fe-2S] cluster, one plan

295 ntly differ from their yeast homologues, and novel proteins with high homology to CORVET/HOPS subunit

296 fold proteins is a promising way to engineer novel proteins with pre-specified functionalities.

297 ry glands produce a small number of abundant novel proteins with yet unknown functions, in addition t

298 e and frequency was comparable for known and novel proteins, with 15 antigens (nine of which were nov

299 that facilitate the de novo generation of a novel protein within an ancestral ORF have remained poor

300 homologous region in IL-22, we engineered a novel protein (Z13-IL22-2) that contains the MPER epitop