ライフサイエンスコーパス: now

1 ex) and point-of-care instruments (Abbott ID NOW).

2 ave never been put under a strong test until now.

3 nd neck have received little attention until now.

4 eases but was long deemed impossible - until now.

5 plex tissues that have remained hidden until now.

6 iduous to avert a public health crisis - for now.

7 ere identified as priorities for eradication now.

8 (100% detection at 1,000 copies/ml), and ID NOW (20,000 copies/ml).

9 ard (98.3%) followed by ePlex (91.4%) and ID NOW (87.7%).

10 ng of anti-IL-6 therapeutics for COVID-19 is now a major line of investigation, with several ongoing

11 Telepsychotherapy, until now a promising but niche treatment, has suddenly become

12 Thus, it is now a real possibility, and of central importance at thi

13 treat drug-resistant tuberculosis, there is now a renewed interest in bicyclic nitroimidazole scaffo

14 ID-19 has spread worldwide since 2019 and is now a severe threat to public health.

15 Quality improvement is now a validated science, and there is clear evidence tha

16 While now a well-recognised non-motor feature of treated PD, m

17 Drought-related tree mortality is now a widespread phenomenon predicted to increase in mag

18 Now, a cationic nanoscale metal-organic framework, W-TBP

19 Now, a simple yet robust acid-treatment strategy is used

20 While we are now able to diagnose inherited thrombophilias in a subst

21 As a result, flexible bronchoscopy is now able to provide a new and expanding armamentarium of

22 Colon polyp surveillance now accounts for 25% of all colonoscopies performed.

23 Early data are now accumulating in progressive thyroid cancers treated

24 od and genetic manipulation of B. microti is now achievable and it is possible to obtain transfected

25 le customization of shape and composition is now achievable for assembling advanced functional compon

26 imetallic metal-organic frameworks (MOFs) is now achieved by polymerization of molecular Ru(2) [II,II

27 Even now, achieving a cure seems to be a rare occurrence amon

28 we demonstrate that the proteomics field is now actively embracing public open data policies.

29 reatment; patients with brain metastases are now addressed in the VTE treatment section; and the reco

30 However, until now advances in Lab-on-Chip have not been translated to

31 response and multisystem organ failure, are now affecting thousands of infected patients and causing

32 living with perinatal HIV infection who are now ageing into adulthood and becoming pregnant.

33 Importantly, it is now agreed that targeting transcription selectively limi

34 This platform will now allow for major drug discovery programmes that addre

35 were established to bypass this obstacle and now allow to image and quantify the entire murine organs

36 with the rapidly falling costs of sequencing now allows comparisons between multiple experiments to i

37 igher level of detail is a step forward that now allows designers to inspect and refine their designs

38 diodes and optical fiber technologies which now allows for a broad range of cost-effective fabricati

39 Now an approach is presented that uses the high sensitiv

40 e spread of invasive alien species (IAS) are now an essential aspect of IAS management.

41 hat led to such widespread use, why there is now an increasing drive to minimize usage, and what alte

42 Now, an unparalleled example of switching between homoly

43 Flow cytometers can now analyze up to 50 parameters per cell and millions of

44 on resources to underserved populations both now and in the future.

45 Launching actions now and learning from past experience can help deliver c

46 2 [Xpert Xpress], Abbott ID NOW COVID-19 [ID NOW], and GenMark ePlex SARS-CoV-2 Test [ePlex]) to dete

47 It is now apparent that p53 plays a critical role in controlli

48 Now, autonomous RAS is on the horizon and the first data

49 Potent C3aR antagonists are now available for interrogating C3a receptor activation

50 mutant collections and genome sequences are now available for these crops, making them attractive ex

51 We focus on the opportunities now available to biologists to study the developmental g

52 Surgical tools and IOLs are now available to bring these rates down to single digits

53 Oral-only anticoagulation strategies are now available, using apixaban or rivaroxaban therapy, be

54 al and genetic studies of higher quality are now available.

55 to define the patient population that would now be considered as refractory to ruxolitinib vs ruxoli

56 re of the U[Formula: see text] compounds may now be drawn, thereby providing suggestions for addition

57 that details of the generated ensembles can now be examined with a high degree of confidence.

58 any molecule that can be electrosprayed can now be explored.

59 two-dimensional infrared (2D-IR) spectra can now be obtained in a matter of seconds, opening up the p

60 biological activity of chitosans, which can now be recognized as bona fide information-carrying mole

61 Eosinophilic esophagitis can now be treated with biologic agents that target specific

62 Innovative SPECT radionuclide pairs have now become available for radiolabeling with the potentia

63 It now becomes clear that cell metabolism is an integral pa

64 -study drug targets at room temperature, has now been adapted for use in synchrotron radiation facili

65 All values have now been corrected to 0(0%).

66 This has now been corrected to: "Division of Life Sciences, State

67 agricultural and medicinal importance, have now been discovered in plant genomes.

68 lived short-scale mode-2 internal waves have now been documented in the Andaman Sea, and we report he

69 symptomatic severe aortic stenosis, TAVI has now been explored across the entire spectrum of operativ

70 sphine-directed C-H borylation of arenes has now been extended to benzylic substrates, providing high

71 dies in the early 2000s, major advances have now been made in the understanding of the pathological a

72 o CTQ during the reaction, two of which have now been structurally characterized by X-ray crystallogr

73 ty of bycaught marine turtles that has until now been unaccounted for in trawl fisheries not equipped

74 the biology and functions of IL-34 are only now beginning to be uncovered.

75 analyses of hormone signaling components are now being complemented by genetic studies in early diver

76 ised by expert chemists whose properties are now being exploited far beyond traditional applications.

77 he non-specific effects of some vaccines are now being tested for their ability to protect against CO

78 r original purposes to study neurons and are now being used to systematically document and interrogat

79 It is now believed that conserved multisubunit protein machine

80 herapies on the response to immunotherapy is now better understood, as well.

81 n coordinated with the two phosphonic groups now bonded to the metal center.

82 However, aircraft now broadcast their location in real-time using the Auto

83 organization of southeastern US salt marshes now burdened by rising sea levels.

84 emical energy storage technology for decades now, but their energy densities are limited by electrode

85 force microscopy, a feat only obtained until now by fluorescence microscopy set-ups with spatial reso

86 Now, by directly manipulating E7 binding to PTPN14 and u

87 udy investigating the BET inhibitor RVX-208 (now called apabetalone) has already been completed.

88 nresponsive to oral iron, iron isomaltoside (now called ferric derisomaltose), compared with ferric c

89 We now can appreciate how multisensory integration can alte

90 studies reveal that Alzheimer's pathologies now can be reliably quantified in vivo using regular blo

91 According to the now canonical theory, reward predictions are represented

92 Extreme heat wave events are now causing ecosystem degradation across marine ecosyste

93 It is now clear that convergence at the genetic level is also

94 However, it is now clear that each symptom can be linked individually t

95 However, it is now clear that modular and reversible PcG function is es

96 It is now clear that multiple astrocyte subsets or activation

97 Although it is now clear that VCA recipients can develop donor-specific

98 We now combine the CsgG nanopore with the 35-residue N-term

99 g field of noncoding RNA-based therapies has now come to the attention of cardiovascular research, in

100 nge coupled to Mass Spectrometry (HDX-MS) is now common practice in structural biology.

101 me psychiatric indication." The authors have now compiled the available evidence to make a clear stat

102 ze penicillins, emergent beta-lactamases can now confer resistance to other beta-lactam drugs, includ

103 Degradation of the glycocalyx is now considered a cornerstone in I/R-related endothelial

104 d on human infections and experimental data, now considered a zoonotic pathogen.

105 Upfront tumour genotyping is now considered an essential step in guiding treatment de

106 int that many aggregation-prone proteins are now considered bona fide prions.

107 mes in patients with pericarditis, and it is now considered standard of care as second-line treatment

108 cells of the peripheral nervous system, are now considered to be important players in the tumor micr

109 within billions of years or less) has until now consisted only of nearly equal-mass (q > 0.9) binari

110 pulation in the Northeast, where epidemic LB now constitutes the most important vector borne disease

111 The database now contains 139 genes-of which 44 are related to ExPEC-

112 Xpress SARS-CoV-2 [Xpert Xpress], Abbott ID NOW COVID-19 [ID NOW], and GenMark ePlex SARS-CoV-2 Test

113 and point-of-care tests such as Abbott's ID NOW COVID-19 Test.

114 using a tree-ring database of surviving and now-dead trees from 118 sites (22 species, >3,500 trees)

115 We now demonstrate that inhibiting NAA synthesis by intraci

116 We now demonstrate that these organic salts, specifically a

117 We now demonstrate that, following selection in the LZ, B c

118 A new study in zebrafish (Liu et al., 2020) now demonstrates a critical role of the Piezo1 mechanose

119 We now describe a computational rendering of our methodolog

120 dOx1 nCoV-19 (AZD1222), in young adults, and now describe the safety and immunogenicity of this vacci

121 We have now determined the atomic structure of the C. jejuni G50

122 We now directly address this question for NMDA receptor-dep

123 ecific in vitro transcription assay, we have now discovered that backbone interactions between the am

124 e an ecological phase shift so that seaweeds now dominate previously coral-rich reefs.(6-8) Discovery

125 drate has been considerably unfeasible until now due to the well-known condensation reaction.

126 es in tissue and regenerative engineering is now easily possible.

127 rical resistivity measurement systems, it is now easy to measure the weighted mobility (electron mobi

128 Although emerging imaging techniques now enable more precise molecular characterization of tu

129 so review how access to these substrates has now enabled biochemical studies that deepen our understa

130 This new assay now enables straightforward large-scale screening for PS

131 for low repetition rate MALDI-2 systems, but now enables substantially enhanced measurement speeds.

132 biology tools in this fascinating organism, now enabling exciting applications - from speeding up ou

133 n highly active for the past 50 years and is now enjoying unprecedented bench-to-bedside clinical suc

134 with ClinicalTrials.gov (NCT03194932) and is now enrolling to address secondary and exploratory objec

135 g interleukin-4 (IL-4), IL-5, and IL-13, are now established biological mechanisms in asthma.

136 gate the high-order structure of proteins is now established, it can be challenging for beta-barrel p

137 f several effective treatment options, it is now even more important to detect and monitor response i

138 We now examined the origin and the role of this innervation

139 vements in organic photovoltaic performance, now exceeding 18% power conversion efficiencies.

140 Although a myriad of methods now exist for the modification of peptides or proteins,

141 We have now expanded this technology to adeno-associated viral v

142 The 70S ribosome structure of E. faecalis now extends our knowledge of bacterial ribosome structur

143 Sample and data management is now feasible through the application, which allows great

144 oups using comparative genomic techniques is now feasible.

145 now find a role for the APP family in neuronal excitabil

146 Zika virus (ZIKV) infection is now firmly linked to congenital Zika syndrome (CZS), inc

147 vel treatment option, including that for the now Food and Drug Administration-approved peanut OIT pro

148 l significance for mitochondrial cristae has now, for the first time, been elucidated at a protonic b

149 Checkpoint inhibitors are now frequently used for oncologic conditions.

150 Flaviviruses are now globally distributed and infect up to 400 million pe

151 ch and drug development, and these cells are now gradually entering the clinical research phase for t

152 or challenge to chemists and the focus since now has mostly been on the synthesis of NH(3).

153 However, several studies have now highlighted the potential for ketone metabolic modul

154 Until now, however, the detailed changes associated with this

155 Until now, however, the protective mechanism has been unknown.

156 Up to now, however, translation of MS-based proteomics to the

157 in tropomyosin, with molecular interactions now identified between tropomyosin and both actin and my

158 ive affect and dysphoria, but recent studies now implicate the kappa opioid system in the modulation

159 Now in Cell Stem Cell, Sommerkamp et al.

160 z-Denoise and pre-trained general models are now included in Topaz.

161 Staging for breast cancer now includes anatomic and biologic factors, although the

162 and bis(2-ethyl hexyl) phthalate (DEHP), are now increasingly being replaced with more environmentall

163 ive site, whereby the beta-lactam antibiotic now is enabled to bind to the active site in its mechani

164 omical, and behavioral data, we believe that now is the time to create integrative benchmarking platf

165 The challenge now is to use limited genetic association studies to fin

166 spend most of their life off the host, until now it has been assumed that the blood and the water vap

167 Now it is shown that one member of a class of high-spin

168 Until now, it has been unclear how the origin DNA is guided by

169 , EBOVAC (grant 115861) and Crucell Holland (now Janssen Vaccines and Prevention B.V.), European Unio

170 Looking back, we now know that the analysis of these mutants revealed the

171 potential in theropods (>=3 times), which we now know was from ancestors already nearing associated t

172 activating MET mutations or fusions are all now known to be drivers of oncogenesis.

173 d sympathetic innervation of numerous organs now known to modulate immune cell function and therefore

174 e done, considerable preclinical evidence is now leading to the initiation of proof-of-concept clinic

175 JENVAC is now licensed as a single-dose Japanese encephalitis vacc

176 Millions of the world's poorest people now live in middle-income democracies that, in theory, c

177 ld Health Assembly resolution on RHD in 2018 now mandates a coordinated global response.

178 Now, molecular imaging methods for the detection of myoc

179 and some upper-MICs, deaths from cancer are now more common than those from cardiovascular disease,

180 The field is now moving from mostly large-scale supraregional studies

181 ll as some previously known genes, which are now newly shown to have functional evidence in humans as

182 able to activate carbon monoxide, and until now, none of them could catalyze its chemical transforma

183 the full scope of their cognition was, until now, not existent.

184 llutants can interact with human skin, it is now of even greater importance that the effects of air p

185 linical management of malignant melanoma and now offer hope to patients with advanced disease.

186 (ICB), chemotherapy, radiation, and/or diet now offer new approaches for cancer therapy.

187 Here I have selected six products that are now on the market, highlighting the underlying technolog

188 Alpha decoding was now only significant in the early (<200 ms) foreperiod.

189 With power conversion efficiency now over 17%, a long operational lifetime is essential f

190 We have now overcome this dilemma by using a multipronged approa

191 These confounds are now overcome, using phase contrast and time-lapse videog

192 Already a versatile research tool, the now oxygenated FABRICA provides easy-to-implement, in vi

193 This flexible tool is now part of routine sequencing analysis at the Departmen

194 eted mutagenesis approaches like CRISPR/Cas9 now permit gene-level investigation of these mechanisms,

195 l COVID-19 death data by racial/ethnic group now permits analysis of age-specific mortality rates for

196 valescent plasma outside such trials is also now permitted through U.S. Food and Drug Administration

197 Using this application, it is now possible to predict biological response along time t

198 ges to the original MiChroM potential, it is now possible to predict experimentally observed inter-ch

199 It is now possible to rapidly identify specific glycan recepto

200 Moreover, it is now possible to visualize not only single genomic loci b

201 le studies in resource-limited countries are now possible.

202 Nimonkar et al. now present a fusion protein between LPL and its physiol

203 ommonly elicited neutralizing antibodies are now present at low frequencies in circulating SARS-CoV-2

204 n vectors expressing PfLSA1 and PfLSAP2 will now proceed to manufacturing and clinical assessment und

205 We have now produced the first documented cloned Atlantic salmon

206 hropogenic climate change and that selection now promotes thermal canalization and robustness.

207 Overall, we now propose that DENV reconfigures phospholipids through

208 The first total synthesis now proves that the structure of this compound had origi

209 We now provide conclusive evidence that the epithelial comp

210 ic and mitochondrial glutamine metabolism is now provided by Yoo et al., identifying the mitochondria

211 ess of engineered cell-based immunotherapies now provides a mechanism to introduce modified FcgammaRs

212 It now provides unprecedented data coverage under an open a

213 We now quantitatively characterize gene repression in livin

214 apeutics, "the dose makes the poison," it is now realized that this aptly applies to the calorigenic

215 Chronic, non-communicable diseases are now recognised as diseases that need to be addressed in

216 rs have been described for many years, it is now recognised that perturbations of the autophagy pathw

217 Researchers now recognize the importance of the coral microbiome, bu

218 While elementary flux mode (EFM) analysis is now recognized as a cornerstone computational technique

219 Dispersal is now recognized as a driver of microbial diversity and fu

220 Excessive sugar intake is now recognized as a key risk factor for obesity, type 2

221 Since nonapoptotic membrane blebbing is now recognized as an important regulator of cell migrati

222 g between immune cells, glia, and neurons is now recognized as indispensable for the initiation and m

223 lation of adenine and cytidine residues, are now recognized as key regulators of both cellular and vi

224 analysis, the vaccination program in Finland now recommends LAIV4 and injectable, tetravalent inactiv

225 The World Health Organization now recommends that typhoid conjugate vaccines (TCV) be

226 for peptides and proteins, although this is now reinforced by extensive theoretical modeling.

227 topologically associating domains (TADs) is now relatively well understood, how chromatin is folded

228 her than deuterated (D(2)O) solvents, and we now report a method that uses the magnitude of the assoc

229 We now report that (1) S-nitrosothiols covalently modify bo

230 We now report that HOPS binds each of the four SNAREs.

231 We now report that mice deficient in conventional T lymphoc

232 We now report the identification and preclinical evaluation

233 We now report the location of this TAM as well as the pleio

234 We now report updated 5-year outcomes of the trial.

235 ational programs to inform of the danger are now required, as public perception has grown that vaping

236 uding that of the human head domain which we now resolve, suggest that ligand specificity derives fro

237 ne rodent once inhabited many islands but is now restricted to several small cays.

238 A new study in Drosophila now reveals that distinct classes of mechanosensory rece

239 We have now screened each member of this library for growth in h

240 (2020), we can all now see how HSCs behave in their niches!

241 We now show AP-1 is a critical component for HCMV reactivat

242 Fontenot et al. now show that Fur purified from Escherichia coli binds a

243 We now show that heparan sulfate proteoglycans (HSPGs) act

244 We now show that the FDA-approved histone deacetylase inhib

245 We now show that water oxidation with the cobalt-corrole Co

246 In fact, evidence has now shown that the stroma is multi-faceted, which illust

247 ctions with ynamides have been developed and now significantly enrich the toolbox of synthetic chemis

248 The most recent applications, now spanning across materials science, nanotechnology, b

249 The virus has now spread to over 168 countries including the United St

250 approaches involving checkpoint blockade are now standard of care in patients with advanced RCC.

251 nce, with applications to bio-image analysis now starting to emerge.

252 SIGNOR 2.0 now stores almost 23 000 manually-annotated causal relat

253 strongly argue that the Protein Data Bank is now sufficiently large to enable proteins to be designed

254 Emerging evidence now suggests that a significant component of sympathetic

255 Although both deserts now support more drier and warmer tolerant species, thei

256 of these secondary effects is becoming vital now that FUS-BBB opening treatments have entered clinica

257 xplanations for religion-health associations now that more people identify as spiritual but not relig

258 Now that predictive accuracies are improving, there is a

259 Now that this latent phenotyping model has been validate

260 The CLSI breakpoint is now the recognized standard that defines AZI susceptibil

261 For half a century now, the barrel cortex of common laboratory rodents has

262 But till now, the experimental progress in this direction in Weyl

263 Until now, the fastest diffusion has been attributed to the mo

264 Now, the first direct experimental evidence of gas-phase

265 Until now, the mechanism by which NIS transports different ani

266 However, until now, the mediators derived from the gut microbiome affec

267 Until now, the most sensitive torque sensor has achieved a rem

268 Until now, the onset and the underlying cause of the atypical

269 Now, the study of tumour metabolism is being redefined b

270 Until now, there has been a lack of analytical methods that ca

271 Now they can be used to remediate the COVID-19 outbreak.

272 field (through the candidate gene strategy), now they often lead the scientific advances in the field

273 uch as diacylglycerols and sphingolipids are now thought to play an important role.

274 Until now, thousands of organic hybrid-POMs have been reported

275 which has emerged in sub-Saharan Africa and now threatens regional food security, we illustrate the

276 xpansion of M. soledadinus, with populations now thriving in low altitude habitats.

277 Until now, time-gated imaging could not be used to develop LFM

278 Hoffmann et al (2020) now uncover that when the epigenetic chromatin cycle fal

279 receptor-driven sympathetic overactivity are now under investigation; thus, the ability to quantify t

280 non-membrane-bound bodies, many of which are now understood as phase-separated condensates.

281 Its general features are now understood, but little detail is known about how the

282 With Phase I/II clinical trials now underway using first-generation vaccines against PfR

283 We now use the composition of lipids that naturally surroun

284 Viruses are now used routinely to study the molecular and cellular f

285 Now, using NMR-based structural and biological approache

286 hort, these meaningful proof-of-concept data now warrant further investigation in a larger patient co

287 Further studies are now warranted to better determine the relevant microcirc

288 Now we argue that another phase can be stabilized in mul

289 Now, we have identified the corresponding gD contact sit

290 Now, we report SAPO-37 as a support for atomically dispe

291 FaceBase 3 now welcomes contributions of data on craniofacial and d

292 d drug discovery and development paradigm is now well established among the pharmaceutical industry a

293 sively studied in the recent years and it is now well-understood that coherence between different ene

294 Electronic health records (EHRs) are now widely adopted in the United States, but health syst

295 It is now widely appreciated that the spatial organization of

296 Non-consumptive predator effects (NCEs) are now widely recognised for their capacity to shape ecosys

297 he need to develop non-dietary treatments is now widely recognized(3), but no pathophysiologically re

298 s including polygenic risk scores (PRSs) are now widely used in medical research; however, few studie

299 cal trial of an investigational drug that is now widely used to treat breast cancer.

300 in 1921, during metal ore mining in what is now Zambia(1).