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1 r of indels made during replication of yeast nuclear DNA.
2 year, an order of magnitude higher than for nuclear DNA.
3 ut shared many haplotypes with the latter at nuclear DNA.
4 polymorphism is linked to differences in the nuclear DNA.
5 ation from organellar DNA in preparations of nuclear DNA.
6 , precluding their use on most alignments of nuclear DNA.
7 3 subunits encoded by both mitochondrial and nuclear DNA.
8 us, whereas APOBEC3A alone efficiently edits nuclear DNA.
9 ferent subunits encoded by mitochondrial and nuclear DNA.
10 different cells possess variable amounts of nuclear DNA.
11 ithful replication of both mitochondrial and nuclear DNA.
12 nstrating the inaccessibility of most of the nuclear DNA.
13 include components that are not specified by nuclear DNA.
14 n be caused by mutations in mitochondrial or nuclear DNA.
15 ch is thought to prevent cGAS from accessing nuclear DNA.
16 on and from contamination of cell debris and nuclear DNA.
17 H 3) 2} 1,2-intrastrand d(GpG) cross-link in nuclear DNA.
18 reactive oxygen species and fragmentation of nuclear DNA.
19 d Chk1/Chk2 phosphorylation and release from nuclear DNA.
20 mount of the triphosphate form (L-OddCTP) in nuclear DNA.
21 ation, and oligonucleosomal fragmentation of nuclear DNA.
22 II trials; however, all of these target only nuclear DNA.
23 ove approximately 20 muM, the complex images nuclear DNA.
24 D4-PLAG1; a fusion between mitochondrial and nuclear DNA.
25 thelia is associated with the degradation of nuclear DNA.
26 ften enriched in the cytoplasm away from the nuclear DNA.
27 -characterized function is repair of damaged nuclear DNA.
28 ell explored in central Europe using ancient nuclear DNA [1, 2], its genetic impact on northern and e
29 was found in 5 cases (mean ratio of mtDNA to nuclear DNA: 239 [95% CI, 217-239] vs 179 [95% CI, 165-1
31 and cytochrome c oxidase subunit I (COI)] or nuclear DNA [adenine nucleotide translocator 1 (ANT1) an
33 ntimicrobial strategy comprising decondensed nuclear DNA and associated histones that are extruded in
34 iminate invading microorganisms by expelling nuclear DNA and histones to form extracellular web-like
35 essential to prevent uracil accumulation in nuclear DNA and indicate that SHMT1-mediated nuclear de
37 ukaryotes (polymerases delta and epsilon for nuclear DNA and polymerase gamma for mitochondrial) are
38 d on the newly synthesized leading strand of nuclear DNA and were present upstream of (G+C)-rich trac
39 Although iPSCs and nt-ESCs shared the same nuclear DNA and yet carried different sources of mitocho
42 The amplicon curves for mitochondrial and nuclear DNA, and the correlations among the curves, were
44 anism by which Ty1 integrase gains access to nuclear DNA as a model for how other retroelements, incl
45 nters the nucleus and reacts with its target nuclear DNA, as determined by platinum atomic absorption
46 ophil extracellular traps (NETs) composed of nuclear DNA associated with histones and granule protein
47 t dendritic cells (DCs) can uptake and sense nuclear DNA-associated entities released by dying cells
50 t that ribonucleotides are incorporated into nuclear DNA beyond their role in priming Okazaki fragmen
52 otein (HMGB1), originally characterized as a nuclear DNA-binding protein, has also been described to
53 cted into wild-type and MNX mice (i.e., same nuclear DNA but different mitochondrial DNA), we showed
54 rison of cells with identical oocyte-derived nuclear DNA but different mtDNA shows that either mtDNA
56 not only are ribonucleotides present in the nuclear DNA, but that they can be incorporated by at lea
57 long noncoding RNAs (lncRNAs) are encoded by nuclear DNA, but the mechanisms that mediate their trans
58 ion between protein and transcript levels of nuclear DNA- but not mtDNA-encoded ETC complex subunits
59 jects, one of their strategies is to release nuclear DNA by the formation of extracellular web-like t
60 esults showed that the copy numbers of viral nuclear DNA can vary by as much as 1.8 orders of magnitu
61 en species (ROS) and the decondensing of the nuclear DNA catalyzed by peptidyl arginine deiminase-4.
62 gress in the study of circulating, cell-free nuclear DNA (ccf-nDNA) in cancer detection has led to th
63 ransferred gene has integrated into sea slug nuclear DNA comes from the finding of a highly diverged
65 l triggering of endocycles results in higher nuclear DNA content (C value) that in some cases has bee
67 use mutants to show that a 16-fold change in nuclear DNA content does not influence the relative size
68 on, as a link in coordinating cell shape and nuclear DNA content in endoreplicated Arabidopsis tricho
72 t visualization and estimation of changes in nuclear-DNA content in live cells during their developme
77 ed by extracellular neurotrophic factors and nuclear DNA damage are integrated by the AKT-mTORC1 path
78 espond to age-related increases in oxidative nuclear DNA damage by forming DNA damage repair foci; ho
79 ased nuclear localization of cDDP, increased nuclear DNA damage by platination, and increased apoptos
80 drial ROS, however, did not cause detectable nuclear DNA damage even when base excision repair was bl
86 find that low doses of RHPS4 do not induce a nuclear DNA damage response but do cause an acute inhibi
87 ngiectasia mutated (ATM) kinase orchestrates nuclear DNA damage responses but is proposed to be invol
89 ron's protective effect against H2O2-induced nuclear DNA damage was greater than the cellular antioxi
91 PCR-based measurements of mitochondrial and nuclear DNA damage, mtDNA damage was preferentially note
92 ial protein oxidation, and mitochondrial and nuclear DNA damage, without interfering with mitochondri
96 oint mutation of mitochondrial DNA or with a nuclear DNA defect (44% and 52%, respectively; P<0.001).
97 only independent predictor associated with a nuclear DNA defect (P=0.002; odds ratio 8.43, 95% confid
100 l feature in mitochondrial disease caused by nuclear DNA defects and single, large-scale mitochondria
107 BEC3A with a TRIB3 expression vector reduced nuclear DNA editing whereas siRNA knockdown of TRIB3 inc
108 A knockdown of TRIB3 increased the levels of nuclear DNA editing, indicating that TRIB3 functioned as
109 ervation may yield substantial quantities of nuclear DNA, enabling novel applications of ancient DNA
110 -binding factor 1), that associated with the nuclear DNA-encoded lncRNA RMRP and mobilized it to mito
111 n adipocytes similarly induced expression of nuclear DNA-encoded mitochondrial ETC genes, including t
112 d genes by regulating expression of multiple nuclear DNA-encoded mitochondrial ribosomal proteins.
113 tion, the basal expression levels of several nuclear DNA-encoded oxidative damage responsive genes wh
114 ith mutations in the gene NDUFS4, encoding a nuclear DNA-encoded subunit of CI (NADH dehydrogenase ub
115 I) and subcellular organelles (mitochondria, nuclear DNA, etc.) not known to affect either focal adhe
118 sults demonstrated there were alterations in nuclear DNA expression and DNA methylation driven by mtD
121 esults suggest that mitochondrial damage and nuclear DNA fragmentation are likely to be critical even
123 al release of apoptosis inducing factor, and nuclear DNA fragmentation resulting in centrilobular nec
124 this leads to mitochondrial dysfunction and nuclear DNA fragmentation, resulting in necrotic cell de
126 ase [GDH] and mitochondrial DNA [mtDNA]) and nuclear DNA fragments were measured in plasma from APAP-
129 r body transfer: all involve the transfer of nuclear DNA from an egg or zygote containing defective m
131 rial Nuclear eXchange mice, that contain the nuclear DNA from one inbred mouse strain, and the mtDNA
134 at low levels of genetic capture of maternal nuclear DNA from other species occur within otherwise an
136 lude the possibility that some mitochondrial-nuclear DNA fusions observed in cancer occurred years ea
137 chondrial genome encompasses over a thousand nuclear DNA genes plus hundreds to thousands of copies o
138 pecific targeting of the metalloinsertors to nuclear DNA gives rise to their cell-selective cytotoxic
139 Furthermore, interplay between mtDNA and nuclear DNA has been found in cancer cells, necessitatin
140 nor nuclei into recipient oocytes, whose own nuclear DNA has been removed, can result in large number
141 a result of DNA damage, mitochondrial DNA or nuclear DNA has been shown to enter the cytoplasm where
142 nscription and nucleotide excision repair of nuclear DNA, however, whether or not XPD exerts similar
144 at antiviral therapy leads to a reduction in nuclear DNA in a manner consistent with symmetrical dist
145 nd apoptotic cells, but whether C1q binds to nuclear DNA in apoptotic cells remains to be investigate
149 ochondrial DNA (mtDNA), the only form of non-nuclear DNA in eukaryotic cells, is a major activator of
154 Deletion of DNase1L2 causes retention of nuclear DNA in the tongue epithelium but not in the skin
156 mice exhibited decreased levels of uracil in nuclear DNA, indicating enhanced de novo thymidylate syn
158 ced enhancement of ROS formation, attenuated nuclear DNA injury, reduced the activation of the nuclea
159 chromosomal abnormalities and the release of nuclear DNA into the cytoplasm, activating the cGAS-STIN
160 iscordance between mitochondrial (mtDNA) and nuclear DNA introgression detected in North American pop
162 hysical studies and a significant portion of nuclear DNA is compacted, a unique effect different from
168 acene (DMBA), cisplatin and etoposide induce nuclear DNA leakage into the cytosol that intrinsically
169 nt correlations were observed between plasma nuclear DNA levels and ex vivo cytokine production.
173 d 467 amplified fragment-length polymorphism nuclear DNA markers, we show that the introduced white s
175 ed to uncouple the inheritance of mtDNA from nuclear DNA may enable affected women to have a genetica
178 bred mouse strain to examine the genome-wide nuclear DNA methylation and gene expression patterns of
179 tosis and micronucleus formation, by loss of nuclear DNA methylation, and by an increased fraction of
180 sial; whether DNMT2 functions primarily as a nuclear DNA methyltransferase or as a cytoplasmic tRNA m
181 We found non-coincident clines in mtDNA and nuclear DNA, mirroring directionality of premating isola
184 es, despite evidence both compounds increase nuclear DNA mutations and demonstrated B[a]P adduct form
185 luated the minimum prevalence of symptomatic nuclear DNA mutations and symptomatic and asymptomatic m
187 hip between concentrations of cell-free (cf) nuclear DNA (ncDNA) and mitochondrial DNA (mtDNA) within
188 ernally inherited mtDNA, the more than 1,000 nuclear DNA (nDNA) bioenergetic genes, and the epigenomi
189 caused greater mitochondrial DNA (mtDNA) and nuclear DNA (nDNA) damage in female mice, indicative of
192 genase (GDH), mitochondrial DNA (mtDNA), and nuclear DNA (nDNA) fragments can be measured in circulat
193 th differences in mitochondrial function and nuclear DNA (nDNA) gene expression, which are recapitula
194 an evolve different anatomical forms through nuclear DNA (nDNA) mutations permitting exploitation of
200 such as doxorubicin (DXR), intercalate into nuclear DNA of cancer cells, thereby inhibiting their gr
201 an epigenetic modification of thymine in the nuclear DNA of flagellated protozoa of the order Kinetop
202 l-hydroxymethyluracil) was discovered in the nuclear DNA of some pathogenic protozoa, such as trypano
203 to sequence 70 and 0.4 megabase pairs (Mbp) nuclear DNA of the Forbes' Quarry and Devil's Tower spec
204 Therefore, partial defects in either the nuclear DNA or mtDNA genes or combinations of the two ca
208 lear antigen (PCNA), the auxiliary factor of nuclear DNA polymerases, plays an important role in regu
210 used whole blood to analyze mitochondrial-to-nuclear DNA ratio (mtDNA/nDNA) using quantitative polyme
211 s, as evidenced by elevated mitochondrial-to-nuclear DNA ratio and increased expression of the mitoch
213 haromyces cerevisiae, we determined mtDNA-to-nuclear DNA ratios in 5148 strains lacking nonessential
214 ases in mitochondrial mass, mitochondrial-to-nuclear DNA ratios, and both nuclear and mitochondrial e
215 bal biological effects, that is, they damage nuclear DNA, reduce the mitochondrial membrane potential
219 However, Lig3 inactivation did not result in nuclear DNA repair deficiency, indicating essential DNA
221 d in detection of a protein complex with the nuclear DNA repair regulator MRE11 in both cell lines, a
222 These results suggest that, contrary to nuclear DNA repair, mitochondrial DNA repair is not able
224 with HAT1 knock-down display mitosis without nuclear DNA replication and also specific de-repression
225 C6-interacting factors also act in T. brucei nuclear DNA replication and demonstrate that TbORC1/CDC6
226 2) is essential in RNA primer removal during nuclear DNA replication and is important in repairing UV
227 an DNA2, originally identified in yeast as a nuclear DNA replication and repair factor, functions exc
228 Early embryonic development features rapid nuclear DNA replication cycles, but lacks mtDNA replicat
229 n MMR in light of increasing knowledge about nuclear DNA replication enzymology and the rate and spec
230 aintain genome stability, mismatch repair of nuclear DNA replication errors must be directed to the n
231 Perhaps surprisingly, our understanding of nuclear DNA replication in kinetoplastids was limited un
232 study, we show that TbOrc1 is essential for nuclear DNA replication in mammalian-infectious bloodstr
234 liest acting components of the kinetoplastid nuclear DNA replication machinery - the factors that dem
238 isiae homologs, Pif1p and Rrm3p, function in nuclear DNA replication, telomere length regulation, and
241 anscript levels of mitochondrial DNA but not nuclear DNA respiratory complex subunits, suggesting act
243 interferon-inducible protein IFI16 acts as a nuclear DNA sensor following HCMV infection, binding vir
244 reveal that KSHV utilizes the innate immune nuclear DNA sensor IFI16 to maintain its latency and rep
246 nted the standard barcoding locus (COI) with nuclear DNA sequence data (ITS2) and analyzed congruence
247 al description, as well as mitochondrial and nuclear DNA sequence data, from another molar (Denisova
250 imescale derived from analyses of multilocus nuclear DNA sequences for Holarctic genera of plethodont
251 amined approximately 32 kilobases of aligned nuclear DNA sequences from 19 independent loci for 169 s
256 clade "Syngnathiformes" following the latest nuclear DNA studies with some revisions on the included
258 ncient mitochondrial genomes and genome-wide nuclear DNA surveys to reveal that the wisent is the pro
263 incorporated in mitochondrial DNA, while in nuclear DNA the ribonucleotide pattern was only altered
265 learly distributes genome-wide in vertebrate nuclear DNA, the state of methylation in the vertebrate
267 ted cytoplasmic population of BAF that binds nuclear DNA to rapidly and transiently localize to the s
268 re formed when neutrophils externalize their nuclear DNA together with antimicrobial granule proteins
271 osomes) with over 70 polypeptides encoded in nuclear DNA, translated on cytoplasmic ribosomes, and im
272 PPD crystal-stimulated neutrophils and their nuclear DNA undergo morphological changes characteristic
275 plains a proportion of the mitochondrial and nuclear DNA variation among moths on different species o
276 the cytokine's activated state) and also to nuclear DNA via its N-terminal CCP module pair (CCP1/2),
278 ated herpesvirus (KSHV) is a human oncogenic nuclear DNA virus that expresses its genes using the hos
279 i's sarcoma-associated herpesvirus (KSHV), a nuclear DNA virus, inhibits mRNA export in a transcript-
281 platin 1,2-intrastrand d(GpG) cross-links on nuclear DNA was confirmed by using a monoclonal antibody
282 in 1,2-intrastrand d(GpG) cross-links on the nuclear DNA was demonstrated by use of a monoclonal anti
284 Relative mtDNA copy number as compared with nuclear DNA was measured by quantitative real-time polym
287 drial content, measured by mitochondrial DNA/nuclear DNA, was higher in sepsis on day 1-2 than contro
289 esions per 10 kb per genome in the mtDNA and nuclear DNA were measured with long-extension polymerase
291 0-fold increase in uracil content in hepatic nuclear DNA when fed a folate- and choline-deficient die
293 responsible for the anticancer activity, is nuclear DNA, which is packaged in nucleosomes that compr
294 e mechanism, mitaplatin thereby attacks both nuclear DNA with cisplatin and mitochondria with DCA sel
295 e were bred to female MNX mice having FVB/NJ nuclear DNA with either FVB/NJ, C57BL/6J, or BALB/cJ mtD
296 il extracellular traps (NETs), consisting of nuclear DNA with histones and microbicidal proteins, are