ライフサイエンスコーパス: nuclear envelope

1 17 and p17 colocalized with lamin A/C at the nuclear envelope.

2 arated centrosome pairs dissociated from the nuclear envelope.

3 elective, bidirectional transport across the nuclear envelope.

4 wever, owing to the complex structure of the nuclear envelope.

5 omatin compaction and repositioning from the nuclear envelope.

6 ytoskeletal linkages (LINC complexes) at the nuclear envelope.

7 g on it and the mechanical properties of the nuclear envelope.

8 s the transfer of physical forces across the nuclear envelope.

9 uclear membranes to form channels across the nuclear envelope.

10 ative regulator of TGFbeta signaling, at the nuclear envelope.

11 ent manner on the cytoplasmic surface of the nuclear envelope.

12 n that are consistent with disruption of the nuclear envelope.

13 ignals and forces are transmitted across the nuclear envelope.

14 ay link the central plaque of the SPB to the nuclear envelope.

15 onal TAN line reporter construct, within the nuclear envelope.

16 lation to the lamin expression levels in the nuclear envelope.

17 s and F-actin did not uniformly decorate the nuclear envelope.

18 7p/CHMP7 and downstream ESCRT factors to the nuclear envelope.

19 he transport of progeny viral capsids to the nuclear envelope.

20 mple physical perturbation of a pre-existing nuclear envelope.

21 wnregulation of the diffusion barrier in the nuclear envelope.

22 GRXS17 resides in both the cytoplasm and the nuclear envelope.

23 (NPCs) regulate all cargo traffic across the nuclear envelope.

24 ficking along microtubules targets it to the nuclear envelope.

25 nge between nucleus and cytoplasm across the nuclear envelope.

26 which are localized to the outer face of the nuclear envelope.

27 ates nucleocytoplasmic transport through the nuclear envelope.

28 physical process mediated by tension in the nuclear envelope.

29 translocating it from the nucleoplasm to the nuclear envelope.

30 hrough the nuclear pores or by rupturing the nuclear envelope.

31 protein lamin A/C is a key component of the nuclear envelope.

32 ing a linear binding of the genome along the nuclear envelope.

33 ion machinery maintains the integrity of the nuclear envelope.

34 indle microtubules that traverse the nascent nuclear envelope.

35 alog torsinB have conserved functions at the nuclear envelope.

36 cortex but remains attached via a thread of nuclear envelope.

37 y for transport of viral proteins across the nuclear envelope.

38 ive protein network that underlies the inner nuclear envelope.

39 loci are preferentially associated with the nuclear envelope.

40 n conduits for molecular exchange across the nuclear envelope.

41 nucleoskeleton and cytoskeleton through the nuclear envelope.

42 SYNE1 (synaptic nuclear envelope 1) encodes multiple isoforms of Nesprin

43 Chromatin and nuclear envelope A-type lamin proteins are known to be k

44 Taken together, this study reveals that the nuclear envelope acts as a reservoir, maintaining COP1 p

45 r tagging fusion (NTF) protein with an outer nuclear-envelope-anchored domain.

46 e endoplasmic reticulum (ER) consists of the nuclear envelope and a reticulated interconnected networ

47 ted a decrease in the elastic modulus of the nuclear envelope and an increase in the pre-tension in c

48 le into a filamentous meshwork, bridging the nuclear envelope and chromatin.

49 localization with ESCRT proteins at sites of nuclear envelope and ER fission and, by genetic analysis

50 al how relaxation of external tethers to the nuclear envelope and internal chromatin-chromatin tether

51 ultiple polymers that transmit forces to the nuclear envelope and into the nuclear interior.

52 Comparisons of shape and integrity of the nuclear envelope and its resistance to stresses found th

53 intain nuclear shape and the fidelity of the nuclear envelope and lamina.

54 The LINC complex spans the nuclear envelope and mediates nuclear mechanotransductio

55 egrity led to centrosome detachment from the nuclear envelope and migration defects.

56 Intriguingly, OPNR localizes to the nuclear envelope and mitochondria.

57 re usually located in close proximity to the nuclear envelope and outside of Yb bodies, whereas their

58 ments that provide structural support to the nuclear envelope and regulate gene expression.

59 rotein Les1, which is localized to the inner nuclear envelope and restricts the process of local nucl

60 ction in regulation of ESCRT proteins at the nuclear envelope and sites of ER tubule fission.

61 SMPD4 showed localization both to the outer nuclear envelope and the ER and additionally revealed in

62 pplying atomic force microscopy (AFM) to the nuclear envelope and the nuclear pore complexes, we demo

63 Telomeres become mobilized from sites on the nuclear envelope and the pericentromere expands after ex

64 n and Cytoskeleton (LINC) complexes span the nuclear envelope and transduce force from dynamic cytosk

65 ntial cellular process occurring in both the nuclear envelopes and mitochondria of dividing cells.

66 In OE CMs, YAP interacts with nuclear-envelope and cytoskeletal components, reflecting

67 tion by mediating the anchoring of L1 to the nuclear envelope, and a new functional link of the nucle

68 MTOCs may emerge on the plasma membrane, the nuclear envelope, and even organelles depending on types

69 icrotubule bundles, spindle-pole bodies, the nuclear envelope, and passive cross-linkers to predict s

70 are gathered into foci, located close to the nuclear envelope, and processed into piRNAs in the cytop

71 cytoskeleton (LINC) complex that bridges the nuclear envelope, and specifically to levels and PTMs of

72 umulates in nuclei, leading to disruption of nuclear envelope architecture, partial sequestration of

73 t al. (2019) find that lamin-A levels in the nuclear envelope are regulated in response to mechanical

74 Collectively, we decipher the MTOC at the nuclear envelope as a bi-layered structure generating tw

75 cytoplasmic components are displaced before nuclear envelope assembly by the movement of chromosomes

76 ent MTOCs in the division plane (eMTOCs) and nuclear-envelope associated MTOCs in interphase cells (i

77 y a marked decrease in expression of several nuclear envelope-associated components (Lamin B1, Lamin

78 gene expression in keratinocytes and suggest nuclear envelope-associated genes as important targets m

79 In humans, mutations affecting nuclear envelope-associated proteins cause laminopathies

80 ations in the nuclei shape and expression of nuclear envelope-associated proteins were accompanied by

81 d connection between stomatal regulation and nuclear envelope-associated proteins, and adds two new p

82 HGPS results from expression and abnormal nuclear envelope association of a farnesylated, truncate

83 chanisms of heterochromatin tethering to the nuclear envelope, autonomous behavior of small genomic s

84 est that nuclear volume is not determined by nuclear envelope availability but by one or more nucleop

85 branes to nuclear rupture sites and prevents nuclear envelope barrier function restoration.

86 Our data suggest that perturbation to the nuclear envelope barrier would lead to local nuclear mem

87 size before mitotic entry, in turn affecting nuclear envelope-based dynein density and motor capacity

88 concerted action of PP2A-B55/SUR-6-regulated nuclear envelope-based dynein pulling forces and centros

89 e-cell imaging platform, we demonstrate that nuclear envelope blebbing occurs rapidly and synchronous

90 n transition begins with germinal vesicle or nuclear envelope breakdown (GVBD) and is critical for oo

91 ted Myosin on the neuroblast cortex prior to nuclear envelope breakdown (NEB).

92 ribution of the mRNAs to the cytoplasm after nuclear envelope breakdown (NEBD) at prometaphase.

93 in interphase and prophase but released upon nuclear envelope breakdown (NEBD) by the action of Cdk1.

94 (CSV) and find that it is reduced soon after nuclear envelope breakdown (NEBD) in human cells.

95 In animal cells, nuclear envelope breakdown (NEBD) is required for proper

96 C first targets cyclin A2 for degradation at nuclear envelope breakdown (NEBD), we find that in zygot

97 erated exclusively by the kinetochores after nuclear envelope breakdown (NEBD).

98 m protein levels increase dramatically after nuclear envelope breakdown [11].

99 mmetric microtubule activities and polarized nuclear envelope breakdown allow for the preferential re

100 of exposing cGAS to chromosomes upon mitotic nuclear envelope breakdown are unknown.

101 The mechanism of local nuclear envelope breakdown in a closed mitosis therefore

102 n a closed mitosis therefore closely mirrors nuclear envelope breakdown in open mitosis(3), revealing

103 iated RNAs after chromosome condensation and nuclear envelope breakdown is unknown.

104 Since nuclear envelope breakdown occurs during mitosis in meta

105 reases in mice after birth, is essential for nuclear envelope breakdown prior to progression to metap

106 t it can be recruited to kinetochores before nuclear envelope breakdown to maintain genomic stability

107 envelope and restricts the process of local nuclear envelope breakdown to the bridge midzone to prev

108 From nuclear envelope breakdown until anaphase onset, GTSE1 b

109 iotic resumption, Plk1 cKO oocytes underwent nuclear envelope breakdown with the same timing as contr

110 on of the retinoblastoma protein and lamins, nuclear envelope breakdown, and duplication of centrosom

111 rier to mitotic establishment corresponds to nuclear envelope breakdown, which requires a decisive sh

112 g it off the apical and lateral cortex after nuclear envelope breakdown.

113 destroyed in prometaphase within minutes of nuclear envelope breakdown.

114 in interfaces to promote NPC disassembly and nuclear envelope breakdown.

115 ls that COP1 preferentially localizes to the nuclear envelope, but it is released from the nuclear en

116 stream regions are gathered into foci at the nuclear envelope, but Yb bodies are not assembled.

117 , which involve alpha-catenin capture at the nuclear envelope by nesprin upon its relaxation, thereby

118 sphorylated MDC1 is dynamically localized to nuclear envelopes, centrosomes, kinetochores, and midbod

119 SINE1, an outer nuclear envelope component of a plant Linker of Nucleosk

120 egradation of substrates in the ER membrane, nuclear envelope, cytoplasm, and nucleoplasm.

121 ever, there were no apparent FUS aggregates, nuclear envelope defects and cytosolic FUS accumulation.

122 MLKL activation in the nucleus, resulting in nuclear envelope disruption, leakage of DNA into the cyt

123 n but is prompted by release of GCL from the nuclear envelope during mitosis.

124 anizing centers move from centrosomes to the nuclear envelope during muscle development.

125 ination with reverse transcription or at the nuclear envelope during nuclear import.

126 P2A-B55/SUR-6 regulation of nuclear size and nuclear-envelope dynein density for proper centrosome se

127 We show that TorA accumulates at nuclear envelope-embedded spindle pole bodies (SPBs) in

128 During cell division, remodelling of the nuclear envelope enables chromosome segregation by the m

129 ion of translation from transcription by the nuclear envelope enables mRNA modifications such as capp

130 Pre-existing organelles, such as the nuclear envelope, endoplasmic reticulum and Golgi appara

131 TorA localizes within the lumen of the nuclear envelope/endoplasmic reticulum and binds to a me

132 Both Golgi and nuclear envelope exhibit MTOC activity utilizing either

133 pindle pole body separation, suggesting that nuclear envelope expansion follows cell-cycle cues rathe

134 Nuclear envelope fluctuations are suppressed on the stif

135 result in a dominant and damaging effect on nuclear envelope formation that correlates with microcep

136 We further found that, during nuclear envelope formation, recruitment of the ESCRT fac

137 smic transport, mitotic spindle assembly and nuclear envelope formation.

138 ed a heterozygous splice site variant in the nuclear envelope gene SYNE1 in a child with severe dilat

139 tachment of centromeres and telomeres to the nuclear envelope, helps to reduce the topological entang

140 and potential membrane delivery at sites of nuclear envelope herniation.

141 Nuclear envelope herniations (blebs) containing FG-nucle

142 es to interrogate the molecular basis behind nuclear envelope herniations seen in mammalian cells lac

143 entromeres and telomeres are attached to the nuclear envelope (i.e. the Rabl configuration) that the

144 first dismantling and later reassembling the nuclear envelope in an 'open mitosis' or by reshaping an

145 During mitosis, however, the nuclear envelope in animal and plant cells disassembles,

146 proteins have been implicated in sealing the nuclear envelope in mammals, spindle pole body dynamics

147 increases membrane flow into and out of the nuclear envelope in response to changes in membrane synt

148 n replication progression associate with the nuclear envelope in sap1 mutant cells.

149 anges in mechanoresponsive components at the nuclear envelope, increased F-actin/G-actin ratios, and

150 e it regulates ESCRT disassembly to maintain nuclear envelope integrity and proper ER architecture.

151 but none are involved in the maintenance of nuclear envelope integrity or ER morphology.

152 Maintenance of nuclear envelope integrity requires the EndoSomal Comple

153 Hallmarks of aged cells include compromised nuclear envelope integrity, impaired nucleocytoplasmic t

154 tractility has been implicated in regulating nuclear envelope integrity, the exact mechanism remains

155 LRRK2 plays an essential role in maintaining nuclear envelope integrity.

156 isease mechanisms linked to NPC assembly and nuclear envelope integrity.

157 uclear envelope, but it is released from the nuclear envelope into the nucleoplasm following Erk1/2 i

158 ckdown, leads to rapid COP1 release from the nuclear envelope into the nucleoplasm where it degrades

159 eRF1 accumulates within elaborate nuclear envelope invaginations in patient induced plurip

160 Nuclear envelope invaginations incorporating SERCA1 in t

161 Recent evidence suggests that the nuclear envelope is a site of regulation of lipid metabo

162 ow that the effective bending modulus of the nuclear envelope is an order of magnitude larger than a

163 Dynein anchored on the nuclear envelope is known to be important for centrosome

164 When the nuclear envelope is reformed, cytoplasmic components are

165 ntury(4), but how the double membrane of the nuclear envelope is split into two at the end of a close

166 at lamin A/C, a scaffolding component of the nuclear envelope, is critical to maintaining the NMJ in

167 f the Nesprin-2 LEWD sequence, implicated in nuclear envelope kinesin recruitment in other systems, i

168 urthermore, we demonstrate a requirement for nuclear envelope LINC (linker of nucleoskeleton and cyto

169 We therefore isolated nuclear envelope lipids from human kidney cells, analyze

170 Furthermore, the nuclear envelope localization of OPNR is dependent on it

171 dent of their kinetochore, spindle pole, and nuclear envelope localization.

172 In this study, we report that the nuclear envelope-localized AAA+ (ATPase associated with

173 results establish an essential role for the nuclear envelope-localized torsinA-LAP1 complex in hepat

174 protein annexin A1 (ANXA1) is present in the nuclear envelope lumen and, through interaction with a l

175 SC-derived neurons using heterochromatin and nuclear envelope markers, as well as DNA damage and glob

176 alculations support the possibility that the nuclear envelope may balance significant mechanical stre

177 disease, and suggest that dysfunction of the nuclear envelope may be an under-recognized component of

178 genome is enclosed within the nucleus by the nuclear envelope membrane, which contains a set of prote

179 pairs recruitment of LEM-domain proteins and nuclear envelope membranes to nuclear rupture sites and

180 size, suggesting that the proper assembly of nuclear envelope might be sensitive to membrane curvatur

181 with findings in mice, marked alterations in nuclear envelope morphology, abnormal localization of Ra

182 vels disrupts endoplasmic reticulum (ER) and nuclear envelope morphology, releasing the kinase Ballch

183 o required for formation and activity of the nuclear envelope MTOC in human osteoclasts.

184 e, we identify AKAP6 as key component of the nuclear envelope MTOC.

185 microtubule (MT) nucleation activity at the nuclear envelope (NE) [1-4].

186 The nuclear envelope (NE) aids in organizing the interphase

187 vising a novel method based on labelling the nuclear envelope (NE) and automatically distinguishing i

188 ate that endogenous RASSF1A localises to the nuclear envelope (NE) and is required for nucleocytoplas

189 involves detachment of chromosomes from the nuclear envelope (NE) and NE breakdown, whereas yeasts m

190 ells triggered CCTalpha translocation to the nuclear envelope (NE) and nuclear lipid droplets (nLDs)

191 omplexes are molecular tethers that span the nuclear envelope (NE) and physically connect the nucleus

192 d spindle pole body (SPB) is embedded in the nuclear envelope (NE) at fusion sites of the inner and o

193 r during interphase via linkages through the nuclear envelope (NE) at the spindle pole body (SPB) and

194 me propagation requires coordination between nuclear envelope (NE) breakdown, spindle formation, and

195 e positioned on the shortest nuclear axis at nuclear envelope (NE) breakdown.

196 te for nuclear escape, a process referred to nuclear envelope (NE) budding.

197 The nuclear envelope (NE) consists of two concentric nuclear

198 d cytoskeleton (LINC) complexes spanning the nuclear envelope (NE) contribute to nucleocytoskeletal f

199 r permeability barrier depends on closure of nuclear envelope (NE) holes.

200 ytoplasmic dynein, kinesin, and actin to the nuclear envelope (NE) in other cell types.

201 of closed mitosis (dinomitosis) wherein the nuclear envelope (NE) invaginates to form one or more tr

202 The nuclear envelope (NE) is continuous with the endoplasmic

203 The nuclear envelope (NE) is critical for numerous fundament

204 germinal vesicle) is unusually large and its nuclear envelope (NE) is densely packed with nuclear por

205 Selective transport across the nuclear envelope (NE) is mediated by the nuclear pore co

206 vide evidence that PLK-1 localization to the nuclear envelope (NE) is required for efficient NEBD.

207 t can cause defects in nuclear transport and nuclear envelope (NE) morphology; however, cellular mech

208 ar rounding, progressive plasma membrane and nuclear envelope (NE) permeabilization, nuclear lamin me

209 The nuclear envelope (NE) presents a physical boundary betwe

210 lines are induced by stretch stimulation and nuclear envelope (NE) proteins including nesprins, SUN2,

211 e muscles revealed cytoplasmic aggregates of nuclear envelope (NE) proteins, nuclear and mitochondria

212 fungi undergo a closed mitosis in which the nuclear envelope (NE) remains intact.

213 is process contributes to subsequent mitotic nuclear envelope (NE) remodeling remains unclear.

214 envelope spectrin 1) that associate with the nuclear envelope (NE) through a C-terminal KASH (Klarsic

215 The nuclear envelope (NE) undergoes dynamic remodeling to ma

216 oskeleton (LINC) complexes, which bridge the nuclear envelope (NE) via the interaction of Klarsicht/A

217 Here we extend brightness analysis to the nuclear envelope (NE), a double membrane barrier separat

218 The nucleus is delineated by the nuclear envelope (NE), which is a double membrane barrie

219 mediates dynein-dynactin localization at the nuclear envelope (NE), which is required for centrosome

220 Interactions occurring at the nuclear envelope (NE)-chromatin interface influence both

221 dies [SPBs]) into fenestrated regions of the nuclear envelope (NE).

222 er SPB (mSPB) on the cytoplasmic side of the nuclear envelope (NE).

223 n assemblies at the plasma membrane (PM) and nuclear envelope (NE).

224 -Cytoskeleton (LINC) bridging complex at the nuclear envelope (NE).

225 calized to the ER membrane, primarily to the nuclear envelope (NE).

226 The presence of herniations at the nuclear envelope of aged cells suggests that misassemble

227 umulation of HIV-1 subviral complexes at the nuclear envelope of macrophages and reduced infectivity.

228 n (FLAP) into higher order assemblies on the nuclear envelope of mast cells; these assemblies were li

229 errepresented relative to FG-nucleoporins in nuclear envelopes of Torsin-deficient cells.

230 ata demonstrate functional links between the nuclear envelope organization, chromatin architecture, a

231 found that both mutations result in similar nuclear envelope perturbations that were reversed in the

232 ctivation, COP1 is rapidly released from the nuclear envelope, promoting the degradation of its nucle

233 Mutation of the nuclear envelope protein barrier-to-autointegration fact

234 als of cells that overexpress the GFP-tagged nuclear envelope protein lamin A.

235 romatin organization by interacting with the nuclear envelope protein Lamin B1, and heterochromatin-a

236 C>T;p.Ser479Phe), the gene which encodes the nuclear envelope protein LEM domain-containing protein 2

237 Here, we identified the nuclear envelope protein nesprin-2 as a binding partner

238 with meiotic telomeres and interact with the nuclear envelope protein SUN1, with a possible crucial r

239 des lamina-associated protein LAP-1, myocyte nuclear envelope protein Syne1, BetaM itself, heme oxida

240 w barrier-to-autointegration factor (BAF), a nuclear envelope protein that shapes chromatin and recru

241 diomyocyte nuclear morphology with increased nuclear envelope proteins and nuclear lamins.

242 h combined deficiencies of three interacting nuclear envelope proteins have normal embryonic developm

243 oted through chromosome movement mediated by nuclear envelope proteins, microtubules, and dynein.

244 In so doing, the nuclear envelope provides a physical barrier between chr

245 s is highly sensitive to the geometry of the nuclear envelope, ranging from twofold to an order magni

246 f cytokinesis and its duration is coupled to nuclear envelope reassembly and the nuclear sequestratio

247 chromatid separation checkpoint" that delays nuclear envelope reassembly and, consequently, Pebble nu

248 Trailing chromatids induce a delay in nuclear envelope reassembly concomitant with prolonged c

249 rapidly and synchronously immediately after nuclear envelope reformation during mitosis.

250 actions, we explored the role of LEM2 during nuclear envelope reformation in human cells.

251 'clock' model, chromosome decondensation and nuclear envelope reformation when cells exit mitosis are

252 am, thereby influencing spindle disassembly, nuclear envelope reformation, and cytokinesis.

253 This acto-myosin network remains on nuclear envelope remnants soon after NEBD, and its myosi

254 Nuclear envelope remodeling drives the formation of a me

255 ng the correct polarity of LD budding at the nuclear envelope, restricting it to the outer membrane.

256 ned contractility causes nuclear dysmorphia, nuclear envelope rupture and genome instability.

257 We detect actin filaments at nuclear envelope rupture sites and define the Rho-ROCK p

258 ls experience extensive nuclear deformation, nuclear envelope rupture, and DNA damage.

259 R12A or PPP1CB causes nuclear fragmentation, nuclear envelope rupture, nuclear compartment breakdown

260 lines, DNA damage is closely associated with nuclear envelope rupture, we show that, in others, mecha

261 mation that may lead to nuclear blebbing and nuclear envelope rupture.

262 to cause DNA damage, even in the absence of nuclear envelope rupture.

263 This deformation-induced DNA damage, unlike nuclear-envelope-rupture-induced DNA damage, occurs prim

264 sting that the sealing of defective NPCs and nuclear envelope ruptures could proceed through similar

265 Cells exhibit transient nuclear envelope ruptures during interphase, but the res

266 Our findings implicate Cdc42 in nuclear envelope sealing and ER remodeling, where it reg

267 The nuclear envelope segregates the genome of Eukaryota from

268 The nuclear envelope serves as important messenger RNA (mRNA

269 UN2, which interact transluminally to form a nuclear envelope-spanning linker molecular bridge known

270 pe 1) encodes multiple isoforms of Nesprin1 (nuclear envelope spectrin 1) that associate with the nuc

271 Upon depletion of desmin (or nesprin [nuclear envelope spectrin repeat protein]-3, its binding

272 Nesprins, nuclear envelope spectrin-repeat proteins encoded by the

273 Lamin B1 plays an important role in the nuclear envelope stability, the regulation of gene expre

274 vates signaling to the actomyosin cortex via nuclear envelope stretch-sensitive proteins, up-regulati

275 beta (mAKAPbeta), which is localized to the nuclear envelope, such that C2C12 skeletal myoblast diff

276 , and 5-LO in higher order assemblies on the nuclear envelope support a model in which arachidonic ac

277 nuclei was redesigned by replacing the outer nuclear-envelope-targeting domain of the nuclear tagging

278 e-based dynein pulling forces and centrosome-nuclear envelope tethering.

279 nt experiments, may result in rupture of the nuclear envelope that can lead to cell death, if not pre

280 min-, and nuclear pore-based channels in the nuclear envelope that extend and retract as acentrics en

281 generates cytosolic DNA species with fragile nuclear envelopes that undergo spontaneous disruption.

282 matin channels capsids are able to reach the nuclear envelope, the site of their nuclear egress.

283 s, AKAP6 anchors centrosomal proteins to the nuclear envelope through its spectrin repeats, acting as

284 how that LINC complexes also signal from the nuclear envelope to critical regulators of the actin cyt

285 on yeast, growing microtubules push onto the nuclear envelope to deform it, which results in fission

286 the end of mitosis, cells must remodel their nuclear envelope to produce two identical daughter nucle

287 focal adhesions, adherens junctions, and the nuclear envelope to regulate YAP/TAZ.

288 ing the actin-dependent forces acting on the nuclear envelope to remodel nuclear shape, which might b

289 computational analysis of the bending of the nuclear envelope under applied force using a model that

290 At baseline, COP1 attaches to the nuclear envelope via interaction with translocated promo

291 Morphology of the nuclear envelope was assessed with immunofluorescence on

292 of subtelomeric domains and tethering to the nuclear envelope were impaired in mutant cells.

293 mating-type region and its boundaries to the nuclear envelope, where Amo1 mutants displayed milder ph

294 The nuclear envelope, which can be modeled as a double lipid

295 exes are multiprotein channels that span the nuclear envelope, which connects the nucleus to the cyto

296 This separation is achieved by the nuclear envelope, which controls the exchange of macromo

297 the proteasome and its anchor, Cut8, at the nuclear envelope, which in turn regulates proteostasis o

298 the cross-talk between the ER and the outer nuclear envelope, while its loss reveals a pathogenic me

299 chromatin and heterochromatin equally to the nuclear envelope will still preferentially locate hetero

300 r versus periphery (less than 1 mum from the nuclear envelope), with the interior DSBs being almost t