ライフサイエンスコーパス: nuclear export

1 to identify candidates that function in tRNA nuclear export.

2 uclear export, cofunctions with Los1 in tRNA nuclear export.

3 ex, known to function in mRNA biogenesis and nuclear export.

4 mpaction of mature transcripts to facilitate nuclear export.

5 e that the proteome can be regulated by tRNA nuclear export.

6 is critical for pre-mRNA processing and mRNA nuclear export.

7 cer of p53 sumoylation by enhancement of its nuclear export.

8 es in structural remodelling checkpoints and nuclear export.

9 SIRT6-mediated deacetylation results in PKM2 nuclear export.

10 cell lung cancer cells to receptor-dependent nuclear export.

11 protein O1 (FOXO1) phosphorylation and FOXO1 nuclear export.

12 4 as the specific transporter mediating PKM2 nuclear export.

13 serve overlapping but distinct roles in tRNA nuclear export.

14 n transcription state and not due to altered nuclear export.

15 and mRNA nuclear export machineries in tRNA nuclear export.

16 the recognition of CTE-RNA and promotes its nuclear export.

17 unspliced tRNA, a hallmark of defective tRNA nuclear export.

18 XPO5 has any additional functions other than nuclear export.

19 ch is accompanied by its destabilization and nuclear export.

20 ization through their direct interaction and nuclear export.

21 mport and nearly complete curtailment of its nuclear export.

22 designed to reversibly inhibit XPO1-mediated nuclear export.

23 d thereby provide a mechanism for initiating nuclear export.

24 e newly transcribed RNA before Xpo1-mediated nuclear export.

25 RNAs are fully processed and appropriate for nuclear export?

26 ient Rev-RcRE complex formation in vitro and nuclear export activity in cell culture.

27 The nuclear export activity of HDAg-L is important for HDV p

28 osomal proteins is coupled to release of the nuclear export adaptor Nmd3.

29 Here, we show that depletion of the nuclear export adaptor SRSF1 prevents neurodegeneration

30 In turn, inhibition of tRNA nuclear export also affected the levels of queuosine mod

31 together with how they are coordinated with nuclear export, also remain only partially characterized

32 NA-binding protein ALYREF plays key roles in nuclear export and also 3'-end processing of polyadenyla

33 D to the nucleus is limited by CRM1-mediated nuclear export and by an uncharacterized mechanism of cy

34 gical functions such as pre-mRNA processing, nuclear export and cap-dependent protein synthesis.

35 rome critical region gene 8 and promotes its nuclear export and degradation by calpain.

36 -induced CDK-interacting protein 1 (p21Cip1) nuclear export and degradation in facilitating human aor

37 le explanations for the relationship between nuclear export and disease.

38 n uncovered putative novel pathways for tRNA nuclear export and extensive links between tRNA biology

39 r of questions remain outstanding about mRNA nuclear export and how it is integrated into the nuclear

40 ells (ESCs) to identify unexpected roles for nuclear export and intracellular Ca(2+) homeostasis duri

41 tor (GPCR) agonist, thrombin-induced p21Cip1 nuclear export and its degradation in promoting HASMC pr

42 NA/Exportin-5 complex from Ran-GTP following nuclear export and its subsequent transfer to a cytoplas

43 However, the flg22-induced nuclear export and phospho-mobility shift can still be o

44 cubated with leptomycin b and MG132 to block nuclear export and proteasome activity, respectively.

45 ve for only GPCR but not RTK agonist-induced nuclear export and proteolytic degradation of p21Cip1 in

46 nting that Los1 participates in both primary nuclear export and re-export of tRNAs to the cytoplasm.

47 at steady state by phosphorylation-dependent nuclear export and subsequent proteolysis in the cytopla

48 uitin E3 ligase for PSD-95, which results in nuclear export and synaptic accumulation of Mdm2 as well

49 eIF4E drives nuclear export and translation of BCL6, MYC, and BCL2 mR

50 and SRSF7, regulators of pre-mRNA splicing, nuclear export and translation-interact with RNA in diff

51 for LTD as inhibition of STAT3-DNA binding, nuclear export, and gene transcription all prevented LTD

52 his process involves CP and RP dissociation, nuclear export, and independent vacuolar targeting of CP

53 th on Rev subcellular trafficking, viral RNA nuclear export, and infectious virion production.

54 The factors that mediate splicing, nuclear export, and translation initiation are recruited

55 h proteins play important roles in splicing, nuclear export, and translation.

56 n of COP1 that is conducive to CRM1-mediated nuclear export, and TRIB1 displaces this intramolecular

57 target of PKCmu, class II deacetylase HDAC5 nuclear export, and, consequently, inhibition of MEF2c a

58 Given that mRNA splicing and nuclear export are coordinated processes, we hypothesise

59 the elements and signals involved in MRTF-A nuclear export are largely unexplored.

60 , and EAR-like domain, which participates in nuclear export, are necessary to maintain higher nuclear

61 xport complex Mex67-Mtr2, for a role in tRNA nuclear export, as described previously in yeast.

62 tubules, various stages of capsid formation, nuclear export by budding into the perinuclear space, te

63 pression of importin-alpha and inhibition of nuclear export by leptomycin B resulted in predominant n

64 mRNA maturation marks and licenses mRNA for nuclear export by loading the export factor NXF1-NXT1.

65 The nuclear export carrier protein CRM1 recognizes this NES-

66 characterized for its essential role in mRNA nuclear export, cofunctions with Los1 in tRNA nuclear ex

67 Nuclear export complexes composed of rev response elemen

68 ers by inhibiting the interaction of TIM and nuclear export component, Exportin 1 (XPO1).

69 xor is the first oral selective inhibitor of nuclear export compound tested for cancer treatment.

70 Selinexor, a selective inhibitor of nuclear export compound that blocks exportin 1 (XPO1) an

71 of selinexor, an oral selective inhibitor of nuclear export compound, in patients with advanced soft

72 ovel, first-in-class, selective inhibitor of nuclear export compound, which blocks exportin 1 (XPO1)

73 Nuclear export control remains poorly understood, in any

74 ed with enhanced HDAC4 (histone deacetylase) nuclear export, creating a microdomain for transcription

75 r pore complex, and its deletion reverts the nuclear export defect of E3 ligase Rsp5 mutants.

76 Striking behaviors include "burst" RNA nuclear export dynamics regulated by HIV-1's Rev respons

77 ing the different steps and coupling them to nuclear export, ensuring that only mature transcripts re

78 a few E3 ligases have been shown to regulate nuclear export, evidence for deubiquitylases is currentl

79 expand on mechanisms known to be mediated by nuclear export factor 1 (NXF1) by describing SR proteins

80 Nuclear export factor 1 (NXF1) exports mRNA to the cytop

81 mportant for general mRNA export mediated by nuclear export factor 1 (Nxf1).

82 Here we show that Nuclear Export Factor 2 (Nxf2) and its co-factor, Nxt1,

83 enome-wide shRNA-based screen, we identified nuclear export factor 3 (NXF3) as a transporter that alt

84 ITA, impair its ability to interact with the nuclear export factor CRM1, and enhance CIITA-induced ge

85 ation by increasing the interaction with the nuclear export factor CRM1.

86 quires CG13741/Bootlegger and the Drosophila nuclear export factor family protein Nxf3.

87 he Mex67:Mtr2 complex is the principal yeast nuclear export factor for bulk mRNA and also contributes

88 at the Ran-binding protein RanBP3L acts as a nuclear export factor for Smad1/5/8.

89 ly inserted into the Drosophila melanogaster nuclear export factor gene nxf2.

90 ulted in cytoplasmic accumulation of the 60S nuclear export factor PA2G4, aberrant ribosome profiles,

91 ex (also known as TAP:p15) is a general mRNA nuclear export factor that is conserved from yeast to hu

92 The splicing and nuclear export factor U2AF65 has the opposite effect, de

93 Nuclear export factors mediate mRNA transit through nucl

94 However, depletion of the nuclear export factors XPO1 or MEX67 recapitulates the e

95 ta show that Mex67-Mtr2 functions in primary nuclear export for a subset of yeast tRNAs.

96 ion and acetylation of FOXO3a results in its nuclear export for degradation and consequent down-regul

97 lts reveal that IkappaBalpha, via its unique nuclear export function, enables, rather than inhibits 4

98 e years, a number of selective inhibitors of nuclear export have been developed.

99 Genome-wide analysis revealed that Hsf1 nuclear export immediately decreased basal transcription

100 ar nuclear export machinery to promote their nuclear export.IMPORTANCE Influenza A virus is a major p

101 yelocytic leukaemia (PML) is mediated by its nuclear export in a chromosomal maintenance 1 (CRM1)-dep

102 ephosphorylated Smad1/5/8 and mediates their nuclear export in a Ran-dependent manner.

103 5, and HDAC9 undergo phosphorylation-induced nuclear export in cardiomyocytes, freeing MEF2 to stimul

104 K signaling had virtually no effect on FoxO1 nuclear export in controls, in contrast to attenuated ex

105 protein, TPR, in regulating mRNA and lncRNA nuclear export in human cells.

106 To evaluate the role of nuclear export in maintaining localization, we inhibited

107 ified deubiquitylase Ubp15 as a regulator of nuclear export in Saccharomyces cerevisiae.

108 study, we sought to determine the role of AR nuclear export in the pathological manifestations of SBM

109 We here visualized nuclear export in trypanosomes by intra- and intermolecu

110 us mRNAs required individual SR proteins for nuclear export in vivo.

111 nt selinexor, an oral selective inhibitor of nuclear export, in patients with relapsed or refractory

112 proposed, including mRNA stabilization, mRNA nuclear export, increased polyadenylation, and transcrip

113 tion of ATM, and IKKgamma/NEMO-dependent ATM nuclear export, indicating activation of the DNA damage

114 Nuclear export inhibition by ORF10 requires an interacti

115 ocalized to the nucleus in the presence of a nuclear export inhibitor.

116 rogress and challenges in the development of nuclear export inhibitors and discuss the potential of e

117 rting in the nucleolus and terminating after nuclear export into the cytoplasm.

118 sis reveals a subset of cellular mRNAs whose nuclear export is blocked by ORF10 with the 3' UTRs of O

119 As tRNA nuclear export is essential, we previously interrogated

120 tRNA nuclear export is of particular interest because it is e

121 ulated by binding Galphai-GDP, whereas RGS14 nuclear export is regulated by Exportin 1 (XPO1).

122 While splicing has been shown to enhance nuclear export, it has remained unclear whether mRNAs ge

123 and show that KPT-335 inhibits XPO1-mediated nuclear export, leading to nuclear accumulation of RSV M

124 ata implicate roles for the protein and mRNA nuclear export machineries in tRNA nuclear export.

125 king viral RNAs to the cellular CRM1/Ran-GTP nuclear export machinery through the activity of Rev's p

126 adaptor between viral mRNAs and the cellular nuclear export machinery to promote their nuclear export

127 etween the viral mRNAs and the cellular mRNA nuclear export machinery.

128 y for nascent chain-60S complexes depends on nuclear export mediator factor (NEMF).

129 NA degradation is cytoplasmic such that mRNA nuclear export must represent an important level of regu

130 pathway, while ERK phosphorylation and FoxO1 nuclear export occur independently of insulin signaling.

131 62, and in L126A-expressing cells, host mRNA nuclear export occurred normally.

132 of FMRP and N(6)-methyladeonsine (m(6)A) on nuclear export of App mRNA.

133 Nuclear export of both HIV-1 and HERV-K mRNAs is depende

134 tration of SRSF1 triggers the NXF1-dependent nuclear export of C9ORF72 transcripts retaining expanded

135 genes is further enhanced by inhibiting the nuclear export of endogenous CIITA.

136 uggests that MBNL1 and U2AF65 play a role in nuclear export of expHTT RNA.

137 response element (RRE), which regulates the nuclear export of gRNAs and other intron-retaining viral

138 diated down-regulation of TAP or Aly reduced nuclear export of HDAg-L and assembly of HDV virions.

139 However, the mechanisms of HDAg-L-mediated nuclear export of HDV ribonucleoprotein are not clear.

140 Calcium-dependent nuclear export of histone deacetylase 1 (HDAC1) was show

141 t protein kinase II activation and prevented nuclear export of histone deacetylase 4 after adrenergic

142 ey mechanism of virulence by NS1 is blocking nuclear export of host messenger RNAs, including those e

143 Here we show that engineered nuclear export of Hsf1 results in cytotoxicity associate

144 binds to the HIV-1 Rev protein and mediates nuclear export of incompletely spliced viral RNAs.

145 1 (CRM1), the HIV-1 Rev protein mediates the nuclear export of incompletely spliced viral transcripts

146 ponse element (RRE) RNA element mediates the nuclear export of intron containing viral RNAs by formin

147 he essential viral Rev protein that mediates nuclear export of intron-bearing late-stage viral mRNAs.

148 iral regulatory protein that facilitates the nuclear export of intron-containing viral mRNAs.

149 factor that is specifically required for the nuclear export of intronless and intron-poor mRNAs and l

150 dentified ALYREF-binding motifs that promote nuclear export of intronless mRNAs.

151 t of p120ctn in complex with MUC1-CT and the nuclear export of kaiso in complex with p120ctn.

152 he possibility that a phenotypically similar nuclear export of large RNAs is cargo driven.

153 r, NXF1 cooperates with CFI-68 to facilitate nuclear export of long 3' UTR isoform with UGUA motifs.

154 scriptional dynamics, 3' end processing, and nuclear export of long 3' UTR transcripts, implicating N

155 We conclude that FMRP may affect the nuclear export of m(6)A-modified RNA targets.

156 is in part caused by the phosphorylation and nuclear export of MAF1 homolog negative regulator of Pol

157 Exportin-1 (XPO1) is the key mediator of nuclear export of many tumor suppressor proteins and is

158 The receptor CRM1 is responsible for the nuclear export of many tumor-suppressor proteins and vir

159 Gastrin-induced nuclear export of menin via cholecystokinin B receptor (

160 Nuclear export of messenger RNAs (mRNAs) is intimately c

161 ribozymes downstream of terminators to block nuclear export of messenger RNAs resulting from RNA poly

162 XPO5 mediates nuclear export of miRNA precursors in a RanGTP-dependent

163 atory mechanism involving the NMD3-dependent nuclear export of mRNA cargos, suggesting a shared platf

164 re where it carries out an essential role in nuclear export of mRNA.

165 dence that TPR is required for the efficient nuclear export of mRNAs and lncRNAs that are generated f

166 he coordination of synthesis, processing and nuclear export of mRNAs.

167 The TREX complex (TREX) plays key roles in nuclear export of mRNAs.

168 has been the only exporter known to execute nuclear export of newly transcribed intron-containing pr

169 ALYREF in coordinating 3'-end processing and nuclear export of non-polyadenylated mRNAs.

170 ls, and these TGF-beta-induced responses and nuclear export of NR4A1 are blocked by NR4A1 antagonists

171 Thus, TGF-beta-induced nuclear export of NR4A1 in TNBC cells plays an essential

172 ed migration of MDA-MB-231 cells by blocking nuclear export of NR4A1, which is an essential step in T

173 Further, blockage of nuclear export of p27 by inhibition of Exportin-1 (XPO1)

174 Nuclear export of partially spliced or unspliced HIV-1 R

175 eraction with NXF1 specifically inhibits the nuclear export of pathological C9ORF72 transcripts, the

176 he contribution of phosphorylation-dependent nuclear export of PER-TIM heterodimers to the maintenanc

177 ripts, and that NCBP3 positively impacts the nuclear export of polyadenylated RNAs and the expression

178 We demonstrate here that the nuclear export of polyQ-expanded AR is impaired, even pr

179 650, are likely responsible for the impaired nuclear export of polyQ-expanded AR.

180 ecessity of a GEF to promote GTP-binding and nuclear export of Ran, the nuclear localization of Ran w

181 HIV-1 Rev is able to mediate the nuclear export of RcRE-containing HERV-K mRNAs, which co

182 mammalian cells, loss of Nup88/214 inhibited nuclear export of recombination signal-binding protein f

183 ev protein to the RRE in vivo and influenced nuclear export of RNA.

184 of the RRE by the viral Rev protein induces nuclear export of RRE-containing RNAs, as required for v

185 f reduced XPO1 expression, disruption of the nuclear export of RSV M protein, and inactivation of the

186 T368 phosphorylation promoted nuclear export of SENP2, leading to downregulation of eN

187 However, how the nuclear export of Smad1/5/8 is regulated remains unclear

188 ere we show that PB components assist in the nuclear export of Ssd1and subsequent targeting of Ssd1 t

189 nhibition of NR4A1 nuclear export results in nuclear export of TGF-beta-induced beta-catenin, which t

190 cap-independent translation and inhibit the nuclear export of the 60S ribosomal subunit, respectivel

191 fine the division plane [5-8]; then, massive nuclear export of the anillin-like protein Mid1 at mitos

192 oss of RdDM in aly1 is a result of deficient nuclear export of the ARGONAUTE6 mRNA and subsequent dec

193 the HIV-1 Rev protein is able to mediate the nuclear export of the HERV-K RcRE, contributing to eleva

194 nvestigated whether Fmr1(KO) associates with nuclear export of the mRNAs for APP protein processing e

195 e breast cancer (TNBC) cells is dependent on nuclear export of the orphan receptor NR4A1, which plays

196 ndole-derived NR4A1 antagonists that inhibit nuclear export of the receptor and thereby block TGF-bet

197 h in turn phosphorylates NR4A1, resulting in nuclear export of the receptor.

198 nal regulators to activate transcription and nuclear export of the resulting messenger RNAs for cytop

199 The nuclear export of the RSV M protein, mediated by the nuc

200 ative splicing of BK channels; this requires nuclear export of the splicing factor Nova-2.

201 fraction of HERV-K loci (Type 2 proviruses), nuclear export of the unspliced HERV-K mRNA appears to b

202 slation of viral mRNAs, it also promotes the nuclear export of the viral late gene mRNAs by acting as

203 d arginine methyltransferase 1) promotes the nuclear export of these mRNAs by methylating the paraspe

204 l control systems act in parallel to prevent nuclear export of unprocessed mRNAs.

205 The HIV-1 Rev protein activates nuclear export of unspliced and partially spliced viral

206 recently reported that nuclear Naf1 promoted nuclear export of unspliced HIV-1 gag mRNA, leading to i

207 ht be an endogenous cellular process for the nuclear export of very large RNPs and protein aggregates

208 f/MEK/ERK) pathway is functionally linked to nuclear export of viral ribonucleoprotein (vRNP) complex

209 virus life cycle through the suppression of nuclear export of vRNP and also interfered with the host

210 ed HIV-1 transcripts for either Rev-mediated nuclear export or degradation.

211 on is dependent on the presence of an intact nuclear export pathway as c-Jun is stabilized and locali

212 HIV-1 requires a specialized nuclear export pathway to transport unspliced and partia

213 d surprising parallels with a novel cellular nuclear export process.

214 ding frames of nonstructural protein 1 (NS1)/nuclear export protein (NEP) for the modified NS segment

215 X (PA-X), Nonstructural Protein 1 (NS1), and Nuclear Export Protein (NEP) genes.

216 We also determine that Rph1 and nuclear export protein Crm1 interact, which is required

217 al studies have shown that inhibition of the nuclear export protein exportin 1 (XPO1) causes nuclear

218 export of the RSV M protein, mediated by the nuclear export protein exportin 1 (XPO1), is crucial for

219 ng by binding to the catalytic groove of the nuclear export protein XPO1 (also known as CRM1, chromos

220 ioavailable, first-in-class inhibitor of the nuclear export protein XPO1, in this phase 1 trial to as

221 oral selinexor, a selective inhibitor of the nuclear export protein XPO1.

222 esponding gene, ALY1, encodes an RNA binding nuclear export protein.

223 nuclear export uses it to complement its own nuclear export proteins (a site not targeted by current

224 s newly synthesized viral proteins with host nuclear export proteins and stabilizes microtubule compl

225 that trypanosomes regulate the completion of nuclear export, rather than the initiation.

226 Targeting nuclear export receptor (exportin 1 [XPO1]) is a novel a

227 ponse element (RRE), to recruit the cellular nuclear export receptor Crm1 and Ran-GTP.

228 Nuclear export receptor CRM1 binds highly variable nucle

229 SET-Nup214 nuclear bodies containing the nuclear export receptor CRM1 were observed in the leukem

230 of both pre-tRNAs and U6 snRNA requires the nuclear export receptor Exportin-5.

231 somal region maintenance 1 (CRM1), the major nuclear export receptor for proteins.

232 The Nxf1 protein is a major nuclear export receptor for the transport of mRNA, and i

233 15 leads to hyper-ubiquitylation of the main nuclear export receptor Mex67 and affects its associatio

234 Chemical perturbation of the nuclear export receptor XPO1 (also known as CRM1), with

235 findings challenge the current paradigm that nuclear export regulates the proteolysis of FOXO3A/4 tum

236 trast to other eukaryotes, the initiation of nuclear export requires neither the completion of transc

237 Inhibition of NR4A1 nuclear export results in nuclear export of TGF-beta-ind

238 ls for three major remodelling events before nuclear export: rotation of the 5S ribonucleoprotein, co

239 The selective inhibitor of nuclear export, selinexor, is in development for the tre

240 717-724 that bears strong homology to known nuclear export sequence (NES) domains.

241 L505R (LR) and R507Q (RQ) located within the nuclear export sequence (NES) of human RGS14.

242 rved nuclear localisation sequence (NLS) and nuclear export sequence (NES), suggesting a role in nucl

243 CD8 T cells harboring a mutated IkappaBalpha nuclear export sequence abnormally accumulate inactive c

244 th the addition of a nuclear localization or nuclear export sequence demonstrates that nuclear accumu

245 hich connects the second helix of Rev to its nuclear export sequence has structural requirements for

246 ility of hydrophobic residues (including the nuclear export sequence), providing a rationale for the

247 impaired in +TIP-TORC1 interactions or Stu2 nuclear export show increased nuclear but not cytoplasmi

248 Using an M mutant with a defective nuclear export signal (MNESmut), however, we revealed th

249 and mutagenesis analyses, we have identified nuclear export signal (NES) (19)LSLRELAI(26) of p17.

250 Furthermore, we identified a nuclear export signal (NES) at the N terminus (AAs 176-1

251 The consensus pattern of Nuclear Export Signal (NES) is a short sequence motif th

252 Nuclear export signal (NES) motifs function as essential

253 rtite nuclear localization signal (bNLS) and nuclear export signal (NES), as well as to a fluorescent

254 Glu571 of CRM1 is located in its nuclear export signal (NES)-binding groove, suggesting t

255 ild-type (wt) SOD1 exposes a normally buried nuclear export signal (NES)-like sequence.

256 l nuclear localization signal and C-terminal nuclear export signal (NES).

257 activity of Rev's prototypical leucine-rich nuclear export signal (NES).

258 ophagy (Atg3) or recombinant NIC tagged to a nuclear export signal (NIC-NES), restored autophagy and

259 BEX3 possess a conserved leucine-rich nuclear export signal and experimental data confirmed BE

260 but only HDAg-L contains a CRM1-independent nuclear export signal at its C terminus.

261 ng site is highly conserved within the first nuclear export signal consensus sequence identified in S

262 We also identified a key nuclear export signal in beta1-chimaerin that is absent

263 entification of an N-terminal Xpo1-dependent nuclear export signal in Dbp5, in addition to other sepa

264 The nuclear export signal of AR (NES(AR)) has an important r

265 Deletion of the nuclear export signal of CHK1 led to its hyperphosphoryl

266 endent phosphorylation of Stu2 adjacent to a nuclear export signal prevents nuclear accumulation of S

267 d that promoting AR export with an exogenous nuclear export signal substantially reduces its aggregat

268 in a leucine-rich stretch, which resembles a nuclear export signal, and could be inactivated by site-

269 ed to the cytoplasm employing a heterologous nuclear export signal, it is expressed at very low level

270 e-and find that the RcRE resembles the HIV-1 nuclear export signal, RRE.

271 hat CD151 is a critical novel host factor of nuclear export signaling whereby the IAV nuclear export

272 localization (NLS1 to -3) and two potential nuclear export signals (NES1 and -2) within MSH3.

273 Classical nuclear export signals (NESs) are short cognate peptides

274 r export receptor CRM1 binds highly variable nuclear export signals (NESs) in hundreds of different c

275 rt of diverse cargos containing leucine-rich nuclear export signals (NESs) through complex formation

276 localization signals (NLSs), as well as the nuclear export signals (NESs), in RPW8.2 is critical for

277 ed to YFP and either nuclear localization or nuclear export signals in N benthamiana showed that cell

278 Prp40 possesses two leucine-rich nuclear export signals, but little is known about the fu

279 Mutations in nuclear export stabilized substrates, and caused accumul

280 remodeling complex as an unanticipated mRNP nuclear export surveillance factor that retains export-i

281 unctional motifs for binding, degradation or nuclear export that function only when the key displaces

282 tion of HDAC4 at Ser(246) and preventing its nuclear export that leads to cytoplasmic degradation of

283 , 11, 21, and 27) demonstrated inhibition of nuclear export through a covalent addition at Cys528 of

284 CstF64- and PABPN1-mediated coupling of mRNA nuclear export to 3' processing.

285 tory syndrome virus (PRRSV) blocks host mRNA nuclear export to the cytoplasm, and nonstructural prote

286 Inhibition of nuclear export triggered the Zalpha-dependent activation

287 of nuclear export signaling whereby the IAV nuclear export uses it to complement its own nuclear exp

288 s inhibited through suppression of p120ctn's nuclear export using leptomycin-B.

289 identify SFiNX (silencing factor interacting nuclear export variant), an interdependent protein compl

290 ecular basis for the inhibition of host mRNA nuclear export was investigated.

291 defect in intronless hemagglutinin (HA) mRNA nuclear export was seen with an NS1 mutant virus.

292 amics of selinexor, a selective inhibitor of nuclear export, when combined with fludarabine and cytar

293 hances Nrf2-mRNA maturation and promotes its nuclear export, whereas AUF1 stabilizes Nrf2-mRNA.

294 gh levels of Paf1 on Pol2 promote transcript nuclear export, whereas low levels reflect nuclear reten

295 t the Nup214 parts mediate the inhibition of nuclear export, whereas the SET or SQSTM1 part determine

296 in release of AR from HSP90, suppression of nuclear export which otherwise dominates over import and

297 factors are required for mRNA biogenesis and nuclear export, which are central to the eukaryotic gene

298 The PRRSV nsp1beta protein blocks host mRNA nuclear export, which has been shown to be one of the vi

299 S1 and NES2 work synergistically to maximize nuclear export, with both being required for IL-6-induce

300 ubnuclear transport of vRNP, abolishing vRNP nuclear export without affecting viral RNA or protein ex