ライフサイエンスコーパス: nuclear family

1 l for the number of ASPs contributed by each nuclear family.

2 orithm-namely, genotype elimination within a nuclear family.

3 t residue 1126 of the mature receptor in one nuclear family.

4 rocesses that operate exclusively within the nuclear family.

5 ultiple parent-offspring pairs from the same nuclear family.

6 COME from 35 hospitals in the UK, and their nuclear family.

7 ated in our previous linkage analysis of 428 nuclear families.

8 ian population-based sample of 232 Caucasian nuclear families.

9 on the basis of data from arbitrary types of nuclear families.

10 t cases included 2,107 Pima Indians from 715 nuclear families.

11 xtended pedigrees were no more powerful than nuclear families.

12 grees and are not restricted to sib pairs or nuclear families.

13 nvolving 186 affected sibling pairs from 160 nuclear families.

14 Children expect saliva sharing to happen in nuclear families.

15 astic effects shared by cousins in different nuclear families.

16 ng of quantitative trait loci (QTL) based on nuclear families.

17 ix SNP and fed these into Transmit using 148 nuclear families.

18 d 29 SNP throughout this region in psoriatic nuclear families.

19 for quantitative traits and extended here to nuclear families.

20 relapsing individuals and 11 controls from 5 nuclear families.

21 aximum detection rate is 34% for four-person nuclear families.

22 hree of 18 unrelated BBS probands from small nuclear families.

23 Findings were confirmed in 52 nuclear families (132 members with clinical phenotypes,

24 rs2299620), in 7,351 Pima Indians from 4,549 nuclear families; 34% of participants had diabetes.

25 A cohort of 49 nuclear families, 40 with familial DCM and 9 with sporad

26 In the 52 nuclear families, 86 individuals (65.2%) were male and t

27 Current approaches using nuclear families accommodate at most several hundred can

28 ase and automated pedigree software, that 23 nuclear families affected with MCPHA are connected to a

29 A total of 234 Finnish JIA nuclear families and 639 elderly Finnish controls withou

30 EHR and geographical locations from 257,620 nuclear families and compile 1083 disease outcome measur

31 tric" linkage analysis of X-linked traits in nuclear families and extended pedigrees.

32 trios, and quartets of biallelic markers in nuclear families and in independent sib pairs.

33 Most families are nuclear families and the average household has 7 persons

34 antitative trait loci have been developed on nuclear-family and extended-pedigree data.

35 merican family-based study population (n=219 nuclear families) and two case-control populations--one

36 tions for a set of tightly linked markers in nuclear families, and the objective is to identify famil

37 ave implemented the basic model for use with nuclear families, and we illustrate its application thro

38 ng in rented homes; (iii) those belonging to nuclear families; and (iv) those with low monthly househ

39 esting, counseling, and risk calculation for nuclear families, as well as extended family members at

40 the MHC region on chromosome 6p21-22 in 225 nuclear families ascertained by African American proband

41 an based on 354 markers in 513 members of 92 nuclear families ascertained through extreme obesity and

42 Sixteen variants were genotyped in 580 nuclear families ascertained through offspring with asth

43 hm for sequence location approximation using nuclear families (ASLAN) to identify the region of origi

44 sease associations for both case-control and nuclear family-based data-including application of corre

45 ide some guidance to investigators designing nuclear family-based linkage disequilibrium studies for

46 sian population, with both case-control- and nuclear-family-based approaches.

47 Analysis of the Nuclear-Family-based cohort revealed that the rate of Eo

48 s, a few of them have been extended to small nuclear families, but none can be applied to large (e.g.

49 lso found in 12 Caucasian Amish kindreds (24 nuclear families) by both sib-pair and transmission dise

50 e phenotyping and genomic analysis utilizing nuclear families can provide a diagnosis in some cases a

51 st three carefully selected individuals in a nuclear family can recover >90% of the information avail

52 In the Nuclear-Family cohort, combined gene and common environm

53 udy, we examined genome screen data from 148 nuclear families, collected without reference to phenoty

54 es in different family structures, including nuclear families commonly used in complex disease gene m

55 l clones (TCC) directed against MOG in three nuclear families, comprised of four individuals affected

56 e performed a genomewide linkage scan in 204 nuclear families comprising 853 individuals and 270 affe

57 ounding by environmental differences between nuclear families, consistent with a possible role for ev

58 A total of 296 nuclear families consisting of a schizophrenia proband,

59 Using a sample of 201 nuclear families consisting of a total of 694 individual

60 The three kindreds, one extended and two nuclear families, contained 13 affected individuals, 11

61 -23 and 20p12 in a cohort of 115 multiethnic nuclear families containing 145 SLE-affected sibpairs.

62 Among 264 nuclear families containing 966 siblings, 516 autosomal

63 We demonstrate this method on a four-member nuclear family, correctly assembling and phasing three g

64 inkage disequilibrium typically are based on nuclear-family data including affected individuals and t

65 The methods are illustrated using nuclear-family data to evaluate the contribution of loci

66 mutation as an inheritance inconsistency in nuclear-family data, as a function of both the number of

67 packages for model-free linkage analysis of nuclear-family data, by applying them to single-marker d

68 d an extensive simulation study on simulated nuclear-family data, varying the number of trait loci, f

69 oach is applicable to either case/control or nuclear-family data, with case/control data modeled via

70 I (Heath 1997) in our simulation study using nuclear-family data.

71 applicable, as a test for linkage, only for nuclear-family data.

72 named XQTL, which uses X-linked markers in a nuclear family design.

73 tism Symptom Scale (BPASS), were measured in nuclear families, each ascertained through two probands

74 were conducted in 3,369 individuals from 906 nuclear families enrolled, without selection, in a longi

75 types from Swedish national samples: intact nuclear families, families with a not-lived-with biologi

76 of complex disease we have regenotyped five nuclear families first studied in the 1996 UK multiple s

77 analysis to obesity, and 236 sib pairs in 82 nuclear families, for linkage analysis to energy metabol

78 These comprised 451 sib pairs in 127 nuclear families, for linkage analysis to obesity, and 2

79 ned 92 affected individuals, representing 82 nuclear families, for mutations, using single-strand con

80 In this study, 413 subjects in 88 nuclear families from a general population sample were e

81 l study included participants from 3 related nuclear families from an Amish community in the primary

82 blood assay in 392 children belonging to 135 nuclear families from an area hyperendemic for tuberculo

83 The PDT can use data from related nuclear families from extended pedigrees and is valid ev

84 tests of association when data from related nuclear families from larger pedigrees are used.

85 Our previous research involving 167 nuclear families from the Autism Genetic Resource Exchan

86 Analyzing 726 meiotic events in 95 nuclear families from the CEPH panel pedigrees, we find

87 Here, we use 489 nuclear families from the mainland USA, Puerto Rico and

88 andard methods require selection of a single nuclear family from any extended pedigrees when testing

89 segregates with a disease phenotype in small nuclear families, from genome-wide oligonucleotide micro

90 Our previous genomewide linkage scan of 428 nuclear families (GeneQuest) identified a significant ge

91 This statistic, when applied to nuclear families, generalizes the transmission/disequili

92 e cousins; N = 10,913) to distinguish within-nuclear-family genetic-nurture effects from dynastic eff

93 In this study, 80 nuclear families have been examined for linkage of total

94 me-wide linkage scans with hundreds of small nuclear families have identified new susceptibility gene

95 Nuclear-Family heritability appeared to be high (72.0%).

96 of the peasant economy is based on autarkic nuclear family households.

97 is of data on multigenerational extended and nuclear families identified the features of structural a

98 asthma index families and randomly selected nuclear families in a rural community in China.

99 The sample included 155 siblings from 42 nuclear families in Brazil.

100 d depression and neuroticism using data from nuclear families in the UK Biobank, with data collected

101 The kindred consists of several related nuclear families in which all parent unions of affected

102 rt comprised 1,037 predominantly white (82%) nuclear families in which at least 1 member had SLE.

103 Nuclear families in which at least one sibling was born

104 transmission of memory disorders differs in nuclear families in which the AD-affected proband did ca

105 We recruited a sample of 393 small nuclear families (including 250 full-sib and 46 half-sib

106 uencing was performed for 43 EoE cases in 18 nuclear families, including 6 relatives without EoE.

107 WES was performed in two nuclear families, including a proband and a parent affec

108 Analysis of 150 nuclear families indicated statistically significant lin

109 ies in 1465 American white subjects from 218 nuclear families indicated that allelic variation at, or

110 At the same time, inferring phase from nuclear families may be hampered by missing family membe

111 encing on the 3 affected puppies, along with nuclear family members (ie, sire, dam, 4 unaffected litt

112 families have larger correlations within the nuclear family members but smaller correlations outside

113 adjusted for age, sex, percent body fat, and nuclear family membership).

114 e storage rate after adjusting for age, sex, nuclear family membership, and percentage of body fat (P

115 o show that what we may regard as the simple nuclear family (mom, dad, and a few kids) is anything bu

116 investigated blood pressure in 1,183 Chinese nuclear families (mother, father, and first two children

117 In a second sample of 298 nuclear families (n=1283 individuals), the Arg16Gly poly

118 In our previous genome-wide scan of Finnish nuclear families, obesity was linked to chromosome Xq24.

119 d nonsmokers, representing approximately 404 nuclear families of African American (AA) or European Am

120 tal of 2037 smokers and non-smokers from 602 nuclear families of African- or European-American (AA or

121 mple consisting of 2037 individuals from 602 nuclear families of African-American (AA) or European-Am

122 ruct a general approach that can accommodate nuclear families of any size, with or without parental i

123 ed out a complex segregation analysis in 636 nuclear families of consecutively ascertained and rigoro

124 found to be associated with total IgE in 420 nuclear families of Costa Rican children with asthma.

125 Participants were 2037 subjects from 602 nuclear families of either African-American (AA) or Euro

126 ch controls the functional activity of NFAT (nuclear family of activated T cell) proteins.

127 HCM in a nuclear family of Golden Retrievers was identified follo

128 scan of 1,261 individuals, representing 402 nuclear families, of African American (AA) origin.

129 The 2,527 offspring came from 1,303 nuclear families, of which 77.6% had two or more sibling

130 tinct units, which will usually be sibships, nuclear families, or small pedigrees.

131 d to include only one affected offspring per nuclear family per extended pedigree; multiple three-mar

132 obese (BMI >or=35 kg/m(2)), and 84.8% of the nuclear families possessed >or=1 morbidly obese sibling

133 of 914 EoE probands (n = 2192 first-degree "Nuclear-Family" relatives) and an international registry

134 tart site by sequencing, and analysis of 562 nuclear families revealed 6 haplotypes.

135 Whole-exome sequencing of a nuclear family revealed that three offspring with childh

136 ample (187 families, 564 subjects), a German nuclear family sample (211 families, 751 subjects) and a

137 211 families, 751 subjects) and a Pittsburgh nuclear family sample (247 families, 729 subjects).

138 ilies (n=1240 individuals) were added to the nuclear family sample, and the Gln27Glu polymorphism in

139 only to triads, whereas some are amenable to nuclear families (sibships).

140 Nuclear family structures are often thought to be essent

141 gregation and heritability based on twin and nuclear family study designs is summarized.

142 region in a sample of 181 sib pairs from 82 nuclear families that were selected on the basis of a dy

143 e prediction intervals, and indeed, in large nuclear families, the majority of children top-scoring f

144 de meals especially for working parents in a nuclear family therefore it is imperative to determine t

145 icate this finding; combined analysis of 194 nuclear families through use of the transmission/disequi

146 ificate data dating back to 1967 and allowed nuclear families to be reconstructed by linking children

147 ssue and then perform simulation studies for nuclear families to compare the methods in terms of powe

148 wo approaches to segregation analysis in 102 nuclear families to estimate genetic models for componen

149 We collected 70 families, ranging from small nuclear families to extended multigenerational pedigrees

150 le-nucleotide polymorphism data collected in nuclear families to localize crossovers with high spatia

151 ypothesis, we resequenced two 3-4 generation nuclear families (totaling 29 individuals) of olive babo

152 d if indirect genetic effects reflect within-nuclear-family transmission ('genetic nurture') or inste

153 one heterozygous for DRD4*7R), including 12 nuclear family trios and 52 trios from four large TS kin

154 Canadian replication cohort consisted of 364 nuclear family trios with one type 1 diabetes-affected o

155 Sample type (oral-vs-fecal) and nuclear family unit were the predominant variables expla

156 We analyzed intermarker LD in 62 nuclear families using microsatellite markers covering e

157 ng the number of affected individuals in the nuclear family was included.

158 iduals of Chinese and Japanese descent, from nuclear families, was genotyped for two polymorphisms, r

159 ed data from 716 Pima Indians comprising 217 nuclear families, we have tested a number of polymorphic

160 Through whole-genome sequencing of large nuclear families, we identified the genomic locations of

161 g all possible affected sib pairs (ASPs) per nuclear family, we obtained a peak maximum LOD score bet

162 the hoarding phenotype in a data set with 53 nuclear families, which were collected by the Tourette S

163 of data simulated for 956 siblings from 263 nuclear families who had participated in a linkage study

164 re generated using 9,291 subjects from 2,900 nuclear families who participated in the National Heart,

165 In a sample of 729 nuclear families with 1089 affected and 1165 unaffected

166 A total of 337 nuclear families with 2 parents and at least 1 biologic

167 enotyping these in an independent set of 636 nuclear families with 974 affected offspring revealed 75

168 Fifty-five nuclear families with at least two asthmatic siblings (2

169 sis of HLA class II alleles in 180 Caucasian nuclear families with at least two children with insulin

170 ng technology in finding causal mutations in nuclear families with dominantly inherited traits otherw

171 an also produce multimegabase haplotypes for nuclear families with just two children and can handle f

172 However, for nuclear families with more than one child, error detecti

173 If the sample contains independent nuclear families with multiple affected children, then o

174 data on a polymorphism of the SDR5A2 gene in nuclear families with multiple cases of prostate cancer.

175 RNA sequencing was performed in nuclear families with multiple EoE cases.

176 jects (815 siblings and 86 parents) from 222 nuclear families with multiple nicotine-addicted sibling

177 h rs2227476 (P = 0.01) was replicated in 240 nuclear families with one affected child from Mali.

178 Here we present a GWAS in 212 nuclear families with pediatric VTE followed by targeted

179 The only LoF variant was identified in a nuclear family with the relatively milder syndrome of ge

180 Analysis of a nuclear family with three affected offspring identified

181 es can be performed by genetic analysis of a nuclear family with three or more children.

182 in 38 702 offspring from 20 905 independent nuclear families, with most of these participants also r

183 It is applicable to any size of nuclear family, with or without ambiguous phase informat

184 Six hundred fifteen nuclear families yielded 870 sib pairs for linkage, with