ライフサイエンスコーパス: nuclear inclusion

1 ed by large intranuclear protein aggregates (nuclear inclusions).

2 accumulates in a single, ubiquitin-positive nuclear inclusion.

3 XN1 colocalized and interacted with ATXN1 in nuclear inclusions.

4 tion but increase the fraction of cells with nuclear inclusions.

5 g its sequestration away from promoters into nuclear inclusions.

6 omoted the accumulation of mutant ATXN7 into nuclear inclusions.

7 y by the presence of neuropil aggregates and nuclear inclusions.

8 to aggregate and form larger cytoplasmic or nuclear inclusions.

9 plicing defects in the absence of detectable nuclear inclusions.

10 redistributed Sp100 to mutant ataxin-1[82Q] nuclear inclusions.

11 Hsp70 decreases the percentage of cells with nuclear inclusions.

12 val lethality, but not neuronal apoptosis or nuclear inclusions.

13 ese neurons weeks prior to the appearance of nuclear inclusions.

14 n of the protein, with large cytoplasmic and nuclear inclusions.

15 th AR species but not to fragment-containing nuclear inclusions.

16 ensity of such cells to form cytoplasmic and nuclear inclusions.

17 ence the appearance or frequency of neuronal nuclear inclusions.

18 ost CBP was not co-localized with huntingtin nuclear inclusions.

19 om the depletion of transcription factors by nuclear inclusions.

20 oduced from the mutant allele is retained in nuclear inclusions.

21 huntingtin, but not normal huntingtin, forms nuclear inclusions.

22 eractive and that contain paramyxovirus-like nuclear inclusions.

23 med vacuoles and filamentous cytoplasmic and nuclear inclusions.

24 that relies on the tobacco etch virus (TEV) nuclear inclusion a (NIa) protease and leads to the coor

25 The WSMV NIb-CP junction containing the nuclear inclusion a (NIa) protease cleavage site was dup

26 e have shown that the protease domain of the nuclear inclusion a protease (NIaPro) from PVY is the el

27 ed that production of a single TuMV protein, Nuclear Inclusion a-Protease (NIa-Pro) domain, was respo

28 Production of a single TuMV protein, nuclear inclusion a-protease domain (NIa-Pro), increased

29 These fragments constituted neuronal nuclear inclusions and appeared before neurological symp

30 give rise to repeat expansion RNAs that form nuclear inclusions and compromise the function of myonuc

31 ainst neuronal dysfunction for polyglutamine nuclear inclusions and exclude significant impairment of

32 he toxic RNA is associated with formation of nuclear inclusions and late-onset degenerative changes i

33 Hallmark features of HD, including nuclear inclusions and neuropil aggregates, were observe

34 BAC-CAG mice show robust striatum-selective nuclear inclusions and transcriptional dysregulation res

35 lation of the mutant Atxn3 protein, abundant nuclear inclusions and, in select brain regions, extranu

36 r membrane blebbing, mitochondrial swelling, nuclear inclusions, and absence of junctional end feet.

37 in nuclear protein aggregation, filamentous nuclear inclusions, and an increase in cell death.

38 on and had tubulointerstitial nephritis with nuclear inclusions, apoptosis, and progressive destructi

39 in HD postmortem brains and by the fact that nuclear inclusions are only detected by antibodies to th

40 -glucuronidase (GUS) were placed between the nuclear inclusion b (NIb) and coat protein (CP) domains

41 and that such resistance is counteracted by NUCLEAR INCLUSION B (NIb), the viral RNA-dependent RNA p

42 no acid sequence of the potato virus Y (PVY) nuclear inclusion b protein is highly homologous to the

43 rganize the VICE domain component Hsc70 into nuclear inclusion bodies that resemble VICE domains.

44 Renal lead-containing nuclear inclusion bodies were frequently observed in WT

45 HDAC4) and MEF2 and colocalizes with them in nuclear inclusion bodies.

46 a large heterogeneity in the dynamics of the nuclear inclusions compared with the compact and immobil

47 c ganglion cells in PrP-SCA7-92Q mice harbor nuclear inclusions composed of transgene-derived ataxin-

48 Nuclear inclusions contained primarily cleaved N-termina

49 the anti-polyP and anti-C terminus mAbs bind nuclear inclusions containing htt.

50 Nuclear inclusions containing polyQ-expanded htt recruit

51 Nuclear inclusions did not appear until 18 months.

52 tant Arx in mouse brains results in neuronal nuclear inclusion formation.

53 icity on the proteins and is associated with nuclear inclusion formation.

54 ell signaling cascades, is incorporated into nuclear inclusions formed by polyglutamine-containing pr

55 tamine protein, ataxin-3, and establish that nuclear inclusions formed by this protein are aggregates

56 We also show CBP incorporation into nuclear inclusions formed in a cell culture model of ano

57 r polyQ tracts led to the formation of intra-nuclear inclusions in a polyQ length-dependent manner du

58 hich aggregate into neuronal cytoplasmic and nuclear inclusions in affected patients, however their c

59 ent of several non-neuronal tissues revealed nuclear inclusions in hepatocytes and choroid plexus epi

60 patients, aggregates were more prominent as nuclear inclusions in NADPH-diaphorase neurons, with les

61 nt is expressed in transgenic mice, it forms nuclear inclusions in neurons and causes early death.

62 similar clinical findings and of viral-like nuclear inclusions in osteoclasts, we hypothesized that

63 4 protein is associated with cytoplasmic and nuclear inclusions in productively infected keratinocyte

64 ology revealed by this reporter and ataxin-7 nuclear inclusions in the vulnerable neurons.

65 Q] in that ataxin-1[82Q]-A776 failed to form nuclear inclusions in tissue culture cells.

66 nd their relocalization into E4-ORF3-induced nuclear inclusions is required for this modification to

67 oxide synthase-positive neurons (which lack nuclear inclusions), loss of nerve fibers in the myenter

68 with an expanded polyglutamine repeat led to nuclear inclusion (NI) formation and late-onset cell deg

69 Nuclear inclusions (NI) are a common finding in hepatocy

70 rounding polyQ specifies the constituents of nuclear inclusions (NI) formed by the disease protein.

71 e 1 (SCA1), aggregates in ubiquitin-positive nuclear inclusions (NI) that alter proteasome distributi

72 lutamine proteins form aggregates, including nuclear inclusions (NI), within neurons, possibly due to

73 generative pathology, and ubiquitin-positive nuclear inclusions (NIs).

74 type-1 (SCA1) and triggers the formation of nuclear inclusions (NIs).

75 seases, the expanded protein aggregates into nuclear inclusions (NIs).

76 Attachment of an exogenous NLS forces nuclear inclusion of Cdc25 in damaged cells.

77 mal machinery, facilitating the reduction of nuclear inclusions of both wild-type and mutant huntingt

78 y play a role in various other diseases with nuclear inclusions or foci containing an RNA binding pro

79 opment in the field since the recognition of nuclear inclusions or the propensity of polyglutamine to

80 Neuronal changes in the striatum (nuclear inclusions) preceded the onset of phenotype, whe

81 e observed complexity in the dynamics of the nuclear inclusions provides a molecular explanation for

82 These cells also contain nuclear inclusions, reminiscent of those seen in paramyx

83 ore nucleated than normal and some contained nuclear inclusions similar to those observed in human PD

84 ar quality control site, a poorly understood nuclear inclusion that coordinates dynamic proteome tria

85 f ATXN7-92Q, inhibiting its aggregation into nuclear inclusions that sequester DUBm components, leadi

86 enic polyQ proteins accumulate in axonal and nuclear inclusions, titrate soluble motor proteins, and

87 pression, mutant ataxin-1, including that in nuclear inclusions, was cleared rapidly from Purkinje ce

88 Nuclear inclusions were present, suggesting that the dis

89 Nuclear inclusions were purified to near homogeneity, an

90 Cs, i.e., the short CTs reveal predominantly nuclear inclusions, whereas the long CTs prominently rev

91 plications in the formation of the insoluble nuclear inclusions, which are characteristic of codon re

92 Intriguingly, the enrichment of nuclear inclusions with slow dynamics parallels changes