ライフサイエンスコーパス: nuclear lamina

1 he chromatin was left "naked" (free from the nuclear lamina).

2 ssociated domains (LADs) are directed to the nuclear lamina.

3 roles in maintaining the organization of the nuclear lamina.

4 mina component lamin A/C, which disrupts the nuclear lamina.

5 tions showed impaired formation of the LMNB1 nuclear lamina.

6 C that is not associated with the peripheral nuclear lamina.

7 and UL53 are required for disruption of the nuclear lamina.

8 n domains that are in close contact with the nuclear lamina.

9 ex evolutionary trajectories for the NPC and nuclear lamina.

10 clear egress that includes disruption of the nuclear lamina.

11 les that were partially dissociated from the nuclear lamina.

12 impaired assembly of mutant lamins into the nuclear lamina.

13 this protein may be a novel component of the nuclear lamina.

14 nd approximately five times greater than the nuclear lamina.

15 from the A compartment and compacted by the nuclear lamina.

16 k underneath the inner nuclear membrane, the nuclear lamina.

17 ner layer of the nuclear envelope called the nuclear lamina.

18 esults in dissociation of LASs/LADs from the nuclear lamina.

19 lls also had significantly less HDAC3 at the nuclear lamina.

20 tted forces damage nuclei with a compromised nuclear lamina.

21 into inactive chromosomal domains along the nuclear lamina.

22 ement with a role for NE81 in formation of a nuclear lamina.

23 cytoskeleton, RNA splicing, DNA repair, and nuclear lamina.

24 of the LMNA gene, are key components of the nuclear lamina.

25 tienzyme complex that is associated with the nuclear lamina.

26 ve protein that changes the structure of the nuclear lamina.

27 proposed to connect the cytoskeleton to the nuclear lamina.

28 be modulated by compositional changes in the nuclear lamina.

29 ns and contributing to the disruption of the nuclear lamina.

30 18 but not 19 is dependent on such a stable nuclear lamina.

31 owing for dissociation of chromatin from the nuclear lamina.

32 products of Lmna, are key components of the nuclear lamina.

33 y the LMNA gene, are basic components of the nuclear lamina.

34 in (Vh) locus regularly colocalizes with the nuclear lamina.

35 amin A, which is a structural protein of the nuclear lamina.

36 d by an intact host cell chromatin layer and nuclear lamina.

37 he INM by rapamycin-mediated trapping at the nuclear lamina.

38 A to lamin A, a structural component of the nuclear lamina.

39 nnecting splicing speckles with sites at the nuclear lamina.

40 ts in loss of integrity and deformity of the nuclear lamina.

41 oding A-type lamins, major components of the nuclear lamina.

42 organization of lamin B1 into domains of the nuclear lamina.

43 in the nucleus, such as nuclear pores or the nuclear lamina.

44 jor filamentous component of the trypanosome nuclear lamina.

45 niations were associated with defects in the nuclear lamina.

46 promotes L1 association with elements of the nuclear lamina.

47 alization of mutant LEMD2 protein within the nuclear lamina.

48 ype I but not Type II probes enriched at the nuclear lamina.

49 , are important structural components of the nuclear lamina.

50 hic PD patients exhibit abnormalities of the nuclear lamina.

51 lation of lamin A/C and the rearrangement of nuclear lamina.

52 tin containing lineage-relevant genes to the nuclear lamina.

53 insights into their role in scaffolding the nuclear lamina.

54 d nuclear elements (LINEs) to the neutrophil nuclear lamina.

55 repeat RNA, is pathogenic by disrupting the nuclear lamina.

56 omatin domains are in close contact with the nuclear lamina.

57 ce from dynamic cytoskeletal networks to the nuclear lamina.

58 asmic domain of SUN2 that interacts with the nuclear lamina.

59 ed with estrogen establish contacts with the nuclear lamina.

60 d the domain of SUN2 that interacts with the nuclear lamina.

61 ner nuclear membrane in association with the nuclear lamina.

62 such as attraction of heterochromatin to the nuclear lamina(2,4), preferential attraction of similar

63 in A and C are fundamental components of the nuclear lamina, a dynamic meshwork of intermediate filam

64 amin B2 are essential building blocks of the nuclear lamina, a filamentous meshwork lining the nucleo

65 ells, lamin B1 is the major component of the nuclear lamina, a filamentous network underlying the nuc

66 Surrounding the chromatin layer is the nuclear lamina, a further host cell barrier to egress.

67 the regulation of nuclear morphology is the nuclear lamina, a meshwork of intermediate lamin filamen

68 Nuclear lamins are components of the nuclear lamina, a structural scaffolding for the cell nu

69 Lamin A/C is a major constituent of the nuclear lamina, a thin filamentous protein layer that li

70 The nuclear lamina-a meshwork of intermediate filaments term

71 LRRK2 knockdown caused nuclear lamina abnormalities and nuclear disruption.

72 defective prelamin A processing, leading to nuclear lamina alterations, severe cardiovascular pathol

73 ilament protein that is a constituent of the nuclear lamina, an important structural element of the n

74 One such structure is the nuclear lamina, an intermediate filament meshwork compos

75 The main function of the nuclear lamina, an intermediate filament meshwork lying

76 Lamins are key structural components of the nuclear lamina, an intermediate filament meshwork that l

77 the nucleus depends on the integrity of the nuclear lamina, an intermediate filament network associa

78 Lamins build the nuclear lamina and are required for chromatin organizati

79 mplex, which couples the cytoskeleton to the nuclear lamina and associated chromatin.

80 ilencing by recruiting the inactive X to the nuclear lamina and by doing so enables Xist to spread to

81 ts into the functional interplay between the nuclear lamina and cellular defenses against oxidative D

82 The nuclear lamina and chromatin interactions are regulated

83 n of a hole nucleated by deformations of the nuclear lamina and estimate the herniation of chromatin

84 es lamin A/C to promote the rearrangement of nuclear lamina and facilitate viral nuclear egress.

85 own a correlation between positioning at the nuclear lamina and gene repression, the functional conse

86 few hotspots that escape segregation to the nuclear lamina and inactivation during cardiogenesis.

87 The nuclear lamina and its associated proteins are important

88 /- mice display decreased circularity of the nuclear lamina and leakage of the nuclear protein 53BP1

89 entify additional roles for lamin A/C of the nuclear lamina and linkers of nucleus to cytoskeleton (L

90 nuclear defects including disorganization of nuclear lamina and loss of heterochromatin.

91 prophase, which promotes disassembly of the nuclear lamina and nuclear envelope breakdown (NEBD).

92 tem that regulates GLI1 movement between the nuclear lamina and nucleoplasm to achieve maximal activa

93 4/dDis3 and dRrp41/dSki6 colocalize with the nuclear lamina and often exhibit a restricted and asymme

94 ear envelope (NE) proteins interact with the nuclear lamina and participate in the architectural comp

95 irus nuclear egress, including disruption of nuclear lamina and particle budding through the inner nu

96 uently and stochastically associate with the nuclear lamina and pericentromeric heterochromatin in CD

97 e inner nuclear membrane with the underlying nuclear lamina and peripheral heterochromatin.

98 o the nuclear rim both for disruption of the nuclear lamina and phosphorylation of the NEC.

99 Lamin B1 is a component of the nuclear lamina and plays a critical role in maintaining

100 to phosphorylate lamin B to help modify the nuclear lamina and promote budding of nucleocapsids at t

101 NA regions that associate chromatin with the nuclear lamina and repress gene activity in fibroblasts.

102 s of actin with nuclear components including nuclear lamina and subnuclear organelles.

103 n proteins leading to the disassembly of the nuclear lamina and subsequent nuclear envelope breakdown

104 ms assemble into complex networks within the nuclear lamina and that A- and B-type lamins have distin

105 e disorganized, suggesting links between the nuclear lamina and the cytoskeleton were disrupted.

106 idence supporting an interaction between the nuclear lamina and the U(L)31/U(L)34 protein complex inc

107 e lamin A/C, resulting in a rearrangement of nuclear lamina and thus facilitating viral nuclear egres

108 ed to Xi chromosomes localized away from the nuclear lamina and were not observed in checkpoint-defic

109 ly with both the nucleolar periphery and the nuclear lamina, and generally display characteristics of

110 UL53 colocalization, prevented disruption of nuclear lamina, and halted productive virus replication

111 her insulator proteins, association with the nuclear lamina, and insulator activity in vivo.

112 n B1 being required for the integrity of the nuclear lamina, and lamin B2 being important for resista

113 dTopors associates with the nuclear lamina, and mutations in lamin disrupt dTopors l

114 min B receptor, an integral component of the nuclear lamina, and that this interaction is required fo

115 individual mitochondria, undulations in the nuclear lamina, and the HER2 receptor on membrane protru

116 f is associated with its detachment from the nuclear lamina, and translocation toward the nucleus cen

117 ar NEC-associated factors that jointly exert nuclear lamina- and membrane-rearranging functions (mult

118 of expanded CGG repeats into FMRpolyG alters nuclear lamina architecture and drives pathogenesis in F

119 lamina protein LAP2beta and disorganizes the nuclear lamina architecture in neurons differentiated fr

120 uclear envelope, nuclear pore complexes, and nuclear lamina are coordinately disassembled.

121 Chromatin domains associated with the nuclear lamina are generally heterochromatic and transcr

122 cells, the main protein constituents of the nuclear lamina are lamins A, C, B1, and B2.

123 show BAF-1 localization and mobility at the nuclear lamina are regulated by stress and unexpectedly

124 B-type lamins, the major components of the nuclear lamina, are believed to be essential for cell pr

125 As nuclear lamina assembled, but preceding DNA synthesis, a

126 on of the MN, which is induced by defects in nuclear lamina assembly, drastically reduces nuclear fun

127 ar level, to defects in the nuclear pore and nuclear lamina assembly.

128 inatorial patterns of histone modifications, nuclear lamina-associated domains, organization of large

129 Here we demonstrate that the nuclear lamina-associated nuclear envelope transmembrane

130 cluding mutations in LMNA, which encodes the nuclear lamina-associated protein lamin A/C.

131 these effects correlated with the segment's nuclear lamina association.

132 defects in telomere clustering and telomere-nuclear-lamina associations.

133 We show that dTopors localizes to the nuclear lamina at prophase, and also transiently to intr

134 lament proteins that form a scaffold, termed nuclear lamina, at the nuclear periphery.

135 or to mitosis, re-associate with the forming nuclear lamina before mitotic exit.

136 me aggregation, gamma-tubulin relocated to a nuclear lamina-bounded compartment in which meiosis-1 sp

137 een proposed to facilitate disruption of the nuclear lamina by recruiting cellular protein kinase C (

138 Because alterations to the nuclear lamina can affect both nuclear morphology and ge

139 es suggest that compositional changes in the nuclear lamina can influence both the steady-state level

140 here it interferes with the integrity of the nuclear lamina, causes misshapen cell nuclei, and leads

141 eal direct control of a conserved LEM domain nuclear lamina component by beta-N-acetylglucosaminyltra

142 n be explained by its phosphorylation of the nuclear lamina component lamin A/C, which disrupts the n

143 identifying NUP-2 as a second trypanosomatid nuclear lamina component.

144 autophagy machinery mediates degradation of nuclear lamina components in mammals.

145 Coincident with these changes, the nuclear lamina components lamin A/C and lamin-associated

146 Our data is consistent with mutations of nuclear lamina components leading to destabilization of

147 Spatiotemporal changes in nuclear lamina composition underlie cell-type-specific c

148 The nuclear lamina consists of A- and B-type lamins.

149 lation at the inner nuclear membrane and the nuclear lamina contributes to the aging process.

150 cytoskeleton) complex and components of the nuclear lamina couple cell spreading or integrin activat

151 n bundles or the LINC complex did not rescue nuclear lamina defects, a previously identified determin

152 and nuclear membrane ruptures at sites with nuclear lamina defects.

153 ers in the interphase nucleus to disrupt the nuclear lamina, demonstrating the importance of the lami

154 Consistent with this finding, nuclear lamina disassembly in the transition from propha

155 onset of chromosome condensation followed by nuclear lamina disassembly.

156 imuli, we show that deregulated Cdk5 induces nuclear lamina dispersion by direct phosphorylation of l

157 In this study, we show that nuclear lamina dispersion is an early and irreversible t

158 g nuclear defects including aberrant shapes, nuclear lamina disruption and reductions to peripheral h

159 (HCMV) kinase UL97 is required for efficient nuclear lamina disruption during nuclear egress.

160 which kinases that normally disassemble the nuclear lamina during apoptosis are recruited to the nuc

161 ase (Hdac3) organizes heterochromatin at the nuclear lamina during cardiac progenitor lineage restric

162 equired for nuclear egress and disruption of nuclear lamina during HCMV infection, and they recruit U

163 , which is associated with disruption of the nuclear lamina during infection, and phosphorylation of

164 retaining chromatin within the bounds of the nuclear lamina during neuronal migration.

165 tment of heterochromatin and nucleoli to the nuclear lamina facilitates the folding of the neutrophil

166 Here, we show that the nuclear lamina filament Lamin B2 (Lmnb2), whose expressi

167 urrently limited, there is evidence that the nuclear lamina filament protein Lamin A/C protects RB fr

168 (2020) show that Lamin B2, a nuclear lamina filament supporting cardiomyocyte karyoki

169 tal connections, Par3 clustering proximal to nuclear lamina folds, and retrograde movement of actin b

170 ytoplasm transport, chromatin remodeling and nuclear lamina formation.

171 otein lamin B, a component of the interphase nuclear lamina, functions in spindle assembly.

172 The association of Rif1 with insoluble nuclear lamina has thus far hampered exhaustive characte

173 f the genome dynamically associated with the nuclear lamina have been identified.

174 ochromatin proteins SUV39H1 and HP1alpha and nuclear lamina-heterochromatin anchoring protein LAP2bet

175 B-type lamins are major constituents of the nuclear lamina in all metazoan cells, yet have specific

176 with late replication and attachment to the nuclear lamina in human cell lines.

177 L)34 proteins modify the conformation of the nuclear lamina in infected cells, possibly by direct int

178 genomic regions, which are positioned at the nuclear lamina in interphase cells prior to mitosis, re-

179 ible system to target a genetic locus to the nuclear lamina in living mammalian cells.

180 The nuclear lamina in migrating neurons was pulled away from

181 s that disruption of the organisation of the nuclear lamina in neurons, perhaps through abnormal neur

182 microscopy reveals a significantly disrupted nuclear lamina in postmortem tissue from human Alzheimer

183 How the perturbation of the nuclear lamina in progeria is transduced into cellular c

184 oundation for redefining the function of the nuclear lamina in the context of tissue building and hom

185 Thus, we have uncovered a role for the nuclear lamina in the integration of EGF signaling to re

186 ur results suggest a mechanistic role of the nuclear lamina in the organization of chromosome territo

187 e useful models for studying the role of the nuclear lamina in various cellular processes.

188 s nucleosome chains and the filaments of the nuclear lamina, in situ.

189 ctase, SHMT, and thymidylate synthase to the nuclear lamina, indicating that SHMT serves as scaffold

190 Conversely, compromising nuclear lamina integrity led to centrosome detachment fr

191 ructure of host cell centrosomes and thereby nuclear lamina integrity.

192 regulated in part through dynamic chromatin-nuclear lamina interactions and that competence of a pro

193 These include the loss of DNA-nuclear lamina interactions, the distension of centromer

194 ere, the portion of CTCF associated with the nuclear lamina interacts with enhancer regions, limiting

195 E24 processes prelamin A, a component of the nuclear lamina intermediate filaments, by cleaving it at

196 lear lamina softening, chromatin stiffening, nuclear lamina invaginations, increase in nuclear height

197 xpression, abnormal histone methylation, and nuclear lamina invaginations.

198 The nuclear lamina is a filamentous structure subtending the

199 The nuclear lamina is a fundamental constituent of metazoan

200 Disassembly of the nuclear lamina is a key step during open mitosis in high

201 The nuclear lamina is a key structural element of the metazo

202 The nuclear lamina is a meshwork of intermediate-type filame

203 The nuclear lamina is a network of structural filaments, the

204 The nuclear lamina is an approximately 10 nm thick proteinac

205 The nuclear lamina is composed mainly of lamins A and C (A-t

206 The nuclear lamina is disassembled during mitosis and apopto

207 fusion, we provide direct evidence that the nuclear lamina is disrupted during HSV-1 infection and t

208 However, the structural organization of the nuclear lamina is poorly understood.

209 kinetics of transcriptional induction at the nuclear lamina is similar to that observed at an interna

210 cytoplasmic assembly compartment, where the nuclear lamina is specifically rearranged, the outer nuc

211 The nuclear lamina is thought to be the primary mechanical d

212 Thus, a key function of the nuclear lamina is to serve as a "fence" and prevent the

213 ysical regulators, including dynein, and the nuclear lamina is unclear.

214 Lamin A, a key component of the nuclear lamina, is generated from prelamin A by four pos

215 exclusively in very discrete regions of the nuclear lamina lacking lamin A/C in the absence of US3 k

216 Studying a key component of the nuclear lamina lamin B1 (LMNB1), we report dynamic alter

217 del that the accumulation of progerin in the nuclear lamina leads to altered H3K27me3 marks in hetero

218 a signaling node and that abnormality in the nuclear lamina leads to dysregulated signaling pathways

219 n of the nuclear envelope, thickening of the nuclear lamina, loss of peripheral heterochromatin, and

220 e results suggest that disintegration of the nuclear lamina mediated by gamma134.5 promotes HSV repli

221 We also identified that Lamin A, a cell nuclear lamina member, is a unique marker of PDL maturat

222 ve vesicles, likely through interaction with nuclear lamina, modulate CENPF localization and levels a

223 e24 processes prelamin A, a component of the nuclear lamina; mutations in the human ortholog of Ste24

224 N-terminal domain localized proteins to the nuclear lamina near sites where mRNA leaves the nucleus.

225 Emerin, a membrane component of nuclear "lamina" networks with lamins and barrier to aut

226 ensional space involves interactions between nuclear lamina (NL) and the lamina-associated domains (L

227 The nuclear lamina (NL) consists of lamin polymers and prote

228 mins, the major structural components of the nuclear lamina (NL) found beneath the nuclear envelope,

229 How the nuclear lamina (NL) impacts on global chromatin architec

230 The nuclear lamina (NL) is an extensive protein network that

231 ian interphase chromosomes interact with the nuclear lamina (NL) through hundreds of large lamina-ass

232 y inactive genes are often positioned at the nuclear lamina (NL), as part of large lamina-associated

233 the mammalian genome is associated with the nuclear lamina (NL), it is interesting to study how nati

234 iption, and increase FXN localization at the nuclear lamina (NL).

235 includes a connection of chromatin with the nuclear lamina (NL).

236 The opening lacks nuclear lamina, nuclear pore complexes, and nuclear memb

237 ssociations of numerous genomic regions with nuclear lamina, nucleoli and surface of chromosomes in t

238 Defects in the nuclear lamina of animal cell nuclei have dramatic effec

239 d, HSV induced conformational changes in the nuclear lamina of infected cells, as viewed after staini

240 trosomes with nuclei or the structure of the nuclear lamina of migrating nuclei.

241 phology and gene expression, we examined the nuclear lamina of senescent cells.

242 tochastically and at high frequency with the nuclear lamina or with pericentromeric heterochromatin i

243 Lamin B1, a key component of the nuclear lamina, plays an important role in brain develop

244 Lamin B1, a key component of the nuclear lamina, plays an important role in brain develop

245 nsation and blocks the formation of both the nuclear lamina-pore complex and nuclear membranes.

246 The reduced deformability of the HGPS nuclear lamina possibly could be due to the inability of

247 Given that the nuclear lamina potentially excludes nucleocapsids from e

248 It is well established that the nuclear lamina preferentially associates with repressed

249 (AGPAT2), a nuclear receptor (PPARgamma), a nuclear lamina protein (LMNA) and its processing endopro

250 Prelamin A, the unprocessed form of the nuclear lamina protein lamin A, accumulated in calcifyin

251 The nuclear lamina protein lamin A/C is a key component of t

252 The nuclear lamina protein lamin A/C is required for FSHD re

253 The mammalian nuclear lamina protein lamin B1 is posttranslationally m

254 the nucleus and directly interacts with the nuclear lamina protein lamin B1, and binds to lamin-asso

255 ype, or SASP), and reduced expression of the nuclear lamina protein LaminB1 (LMNB1) [1].

256 FMRpolyG interacts with the nuclear lamina protein LAP2beta and disorganizes the nuc

257 The Drosophila nuclear lamina protein YA binds to chromatin and is uniq

258 The Drosophila nuclear lamina protein YA is essential for the transitio

259 n CROWDED NUCLEI (CRWN), which are candidate nuclear lamina proteins in Arabidopsis (Arabidopsis thal

260 n, Arg527His, in the LMNA gene which encodes nuclear lamina proteins lamins A and C has been reported

261 M proteins EMR-1 and LEM-2, depletion of the nuclear lamina proteins LMN-1 or BAF-1, or the depletion

262 pathophysiology underlying HGPS, and how the nuclear lamina regulates proliferation and chromatin org

263 e chromatin formation and maintenance at the nuclear lamina remain poorly understood.

264 The nuclear lamina represents a protein network required for

265 gerin adversely affects the integrity of the nuclear lamina, resulting in misshapen nuclei and nuclea

266 E7 failed to restore gaps in the nuclear lamina seen in wild-type but not UL97-null virus

267 Removal of PP2A-B55/SUR-6 and the nuclear lamina simultaneously further disrupted centroso

268 nvolves disruption of the host chromatin and nuclear lamina so that the RC can approach the nuclear e

269 ons in the properties of the nucleus such as nuclear lamina softening, chromatin stiffening, nuclear

270 ain protein emerin, a conserved component of nuclear "lamina" structure, or with a complex containing

271 rough opposite effects on MAN1 levels at the nuclear lamina, suggesting a new perspective on disease

272 actor (BAF) is an essential component of the nuclear lamina that binds lamins, LEM-domain proteins, h

273 ns of emerin, another component of the inner nuclear lamina that directly interacts with LMNA.

274 ation abnormality is explained by a weakened nuclear lamina that interferes with nucleokinesis, a nuc

275 repositioning of chromosomal regions to the nuclear lamina that is dependent on breakdown and reform

276 ci enriched in cell cycle regulator genes to nuclear lamina that mediates the CTCF function.

277 ich subsequently leads to alterations of the nuclear lamina that repress active viral chromatin state

278 ) show disruption of the organization of the nuclear lamina that underlies the nuclear envelope.

279 leation around the nucleus that disrupts the nuclear lamina, the main structure limiting nuclear defo

280 ms that determine their association with the nuclear lamina, their dynamic links with other nuclear c

281 located adjacent to the nucleolus or to the nuclear lamina, thus defining nucleolus-associated domai

282 Igh relocated from the nuclear lamina to central domains only at the pro-B cell

283 nt, unanticipated interplay between CTCF and nuclear lamina to control the transcription of ER target

284 bridge the nuclear envelope, connecting the nuclear lamina to cytoskeletal components.

285 heterochromatin enhances the ability of the nuclear lamina to maintain the sturdiness and shape of t

286 ponent of the LINC complex that connects the nuclear lamina to the actin cytoskeleton.

287 and cytoskeleton (LINC) complex connects the nuclear lamina to the cytoskeleton, in part to aid in nu

288 nd the outer nuclear membranes, connects the nuclear lamina to the cytoskeleton.

289 toskeleton (LINC) complex--which connect the nuclear lamina to the cytoskeleton.

290 ion during nuclear remodeling by linking the nuclear lamina to the cytoskeleton.

291 s localized to mitochondria-ER junctions and nuclear lamina, two compartments that are recalcitrant t

292 us, where it mediates the degradation of the nuclear lamina upon oncogenic insults to reinforce cellu

293 In animals, NPCs are anchored by the nuclear lamina, which ensures their even distribution an

294 The peripheral nuclear lamina, which is largely but not entirely associ

295 The nuclear lamina, which provides a structural scaffolding

296 at the nuclear periphery in contact with the nuclear lamina, which provides mechanical stability to t

297 n, depend critically on the integrity of the nuclear lamina, which suggest the existence of a functio

298 B cell factor (Ebf1) was sequestered at the nuclear lamina, which thereby preserved their multipoten

299 this is due to its role in disruption of the nuclear lamina, which would otherwise impede nuclear egr

300 r envelope, and a new functional link of the nuclear lamina with transcriptional repression.