ライフサイエンスコーパス: nuclear pore complex

1 ckade of the phenylalanine-glycine (FG)-rich nuclear pore complex.

2 clear periphery through interaction with the nuclear pore complex.

3 beta1, which drives the receptor through the nuclear pore complex.

4 Nup35 gene, which encodes a component of the nuclear pore complex.

5 rtin beta1 and Ran-GTPase, components of the nuclear pore complex.

6 ed promoter region (TPR), a component of the nuclear pore complex.

7 and in achieving proper configuration of the nuclear pore complex.

8 and is stabilized by an interaction with the nuclear pore complex.

9 erlie mechanistic and kinetic control in the nuclear pore complex.

10 l channel, or on the cytoplasmic face of the nuclear pore complex.

11 ng protein cargoes for transport through the nuclear pore complex.

12 eptor TAP/NXF, which guides mRNA through the nuclear pore complex.

13 d the assembly of the coatomer module of the nuclear pore complex.

14 ction of cis-acting "DNA zip codes" with the nuclear pore complex.

15 gel using protein fragments derived from the nuclear pore complex.

16 cleus, including several constituents of the nuclear pore complex.

17 of cells lacking Pom152, a component of the nuclear pore complex.

18 tified as the protein that disintegrates the nuclear pore complex.

19 oplasmic reticulum (ER) that is gated by the nuclear pore complex.

20 sically interacts with key components of the nuclear pore complex.

21 of the AAL signal localizes in proximity to nuclear pore complexes.

22 al properties of the permeability barrier of nuclear pore complexes.

23 cient to ensure the even distribution of the nuclear pore complexes.

24 senger RNAs (mRNAs) to the cytoplasm through nuclear pore complexes.

25 mRNAs bound to the transport factor NXF1 to nuclear pore complexes.

26 ery and requires Nup2, suggesting a role for nuclear pore complexes.

27 lear translocation through components of the nuclear pore complex(2-4).

28 Grima et al. (2017) describe defects in the nuclear pore complex and impaired nucleocytoplasmic tran

29 ependent on the Nup107-160 subcomplex of the nuclear pore complex and is modulated through interactio

30 t of nucleoporins (Nups) can detach from the nuclear pore complex and move into the nuclear interior

31 s, might help vaults safely pass through the nuclear pore complex and potentiate their role as self-r

32 mbrane-less organelles such as nucleoli, the nuclear pore complex and stress granules.

33 rallel CC of the dynein stalk region and the nuclear pore complex and suggests that this one-dimensio

34 modeling as they are first acted upon by the nuclear pore complex and then by the ribosome.

35 vealing the octameric arrangement of Xenopus nuclear pore complexes and by quantifying the diffusion

36 ess the ability to enter the nucleus through nuclear pore complexes and can infect interphase cells,

37 istic step in Gle1's mRNA export function at nuclear pore complexes and directly implicate altered ex

38 compaction that facilitates movement through nuclear pore complexes and the length of transcript poly

39 olecule exchange, it has become evident that nuclear pore complexes and their components also have mu

40 indings that highlight the dynamic nature of nuclear pore complexes and their roles in many cell type

41 s membranes, by shuttling cargos through the nuclear pore complex, and by triggering the formation of

42 nteracts with both RNA polymerase II and the nuclear pore complex, and its deletion reverts the nucle

43 NUP107 is a component of the nuclear pore complex, and the NUP107-associated protein

44 stration between fluorescently labeled mRNA, nuclear pore complexes, and chromatin, we obtained globa

45 The opening lacks nuclear lamina, nuclear pore complexes, and nuclear membrane, but it is

46 tosol by employing anti-beta-tubulin or anti-nuclear pore complex antibody as cargo.

47 e nuclear periphery and interaction with the nuclear pore complex are prerequisites for gene clusteri

48 Nuclear pore complexes are composed of approximately 30

49 Nuclear pore complexes are fundamental components of all

50 Nuclear pore complexes are multiprotein channels that sp

51 included in developing models and using the nuclear pore complex as an example to illustrate the pra

52 e stereotypic arrangement of proteins in the nuclear pore complex as in situ reference structures to

53 Increasing evidence points to nuclear pore complexes as important regulators of cell f

54 lar or identical to those needed for de novo nuclear pore complex assembly.

55 smic transport and accumulations of specific nuclear-pore-complex-associated proteins have been repor

56 Moreover, we provide evidence that a nuclear pore complex associates with the duplicating SPB

57 nk between the Torsin/cofactor system and NE/nuclear pore complex biogenesis or homeostasis and estab

58 mutants are insensitive to a Nup62-mediated nuclear pore complex blockade in cells that potently blo

59 Here, we use an inducible nuclear pore complex blockade to monitor the kinetics of

60 east, some inducible genes interact with the nuclear pore complex both when active and for several ge

61 Most models propose transport through the nuclear pore complexes, but a central outstanding questi

62 umulate in a storage of improperly assembled nuclear pore complexes compartment, or SINC.

63 Nuclear pore complex components (Nups) have been implica

64 The Hog1 SAPK associates with nuclear pore complex components and directly phosphoryla

65 of studies have reported the involvement of nuclear pore complex components in embryogenesis, cell d

66 Nuclear pore complexes consist of several subcomplexes.

67 Nuclear pore complexes control the exchange of macromole

68 The nuclear pore complex controls the passage of molecules v

69 ous intracellular compartments including the nuclear pore complex, COPII-coated vesicles, and inside

70 e provide insight into how compartmentalized nuclear pore complex disassembly allows cells that under

71 The NIMA kinase is required for mitotic nuclear pore complex disassembly and potentially control

72 rdered Phe-Gly nucleoporins (FG Nups) within nuclear pore complexes exert multivalent interactions wi

73 Tpr, a component of the NPCs (nuclear pore complexes), facilitates the formation of th

74 While NUP107 is required for nuclear pore complex function in somatic cells of flies

75 Nuclear pore complexes have emerged in recent years as c

76 ddition to its well-defined interaction with nuclear pore complexes, here we find that Gle1 is enrich

77 omolecular complexes with an emphasis on the nuclear pore complex, holding great potential for applic

78 process occurs for the core subunits of the nuclear pore complex in both young and aged cells.

79 Our study also unveils a role for the nuclear pore complex in resolving replication defects at

80 fission yeast, and surveillance of defective nuclear pore complexes in budding yeast.

81 ith nuclear membrane but devoid of lamin and nuclear pore complexes in Drosophila melanogaster.

82 that facilitate selective transport through nuclear pore complexes in eukaryotic cells.

83 tructured substrates and the distribution of nuclear pore complexes in myoblasts differentiated on a

84 entional fluorophores, we have imaged single nuclear pore complexes in the nuclear membrane and aggre

85 Recording nanobody-labeled nuclear pore complexes in Xenopus laevis cells showed th

86 , which is shared by several proteins of the nuclear pore complex, including those in the central cha

87 that an increase (decrease) in the number of nuclear pore complexes increases (decreases) the number

88 is activity is also important for interphase nuclear pore complex insertion into growing germline nuc

89 , thereby inhibiting mRNA export through the nuclear pore complex into the cytoplasm for translation.

90 It initiates assembly of nuclear pore complexes into functional nuclear pores tow

91 Here, we genetically show that an intact nuclear pore complex is important for cell survival and

92 lear pore complex; its exact function in the nuclear pore complex is still unknown.

93 The nuclear pore complex is the primary conduit for nuclear

94 The nuclear pore complex is the sole mediator of bidirection

95 f HIV-1 replication complexes through intact nuclear pore complexes is critical for successful infect

96 is a nuclear membrane protein comprising the nuclear pore complex; its exact function in the nuclear

97 lo-like kinase 1 (PLK-1) is recruited to the nuclear pore complexes, just prior to NEBD, through its

98 are stacked ER-derived membranes containing nuclear pore complex-like structures whose fate and func

99 The nuclear pore complex mediates nucleocytoplasmic transpor

100 exerts its function and whether it modulates nuclear pore complex (NPC) activity remain unknown.

101 Multiple components of the nuclear pore complex (NPC) and a second coiled-coil prot

102 uncover two metformin response elements: the nuclear pore complex (NPC) and acyl-CoA dehydrogenase fa

103 found that SARS-CoV-2 Orf6 localizes at the nuclear pore complex (NPC) and directly interacts with N

104 NUP188 encodes a scaffold component of the nuclear pore complex (NPC) and has been implicated as a

105 ding yeast, targeting of active genes to the nuclear pore complex (NPC) and interchromosomal clusteri

106 Nuclear transport is facilitated by the Nuclear Pore Complex (NPC) and is essential for life in

107 We detected two exceptions: the nuclear pore complex (NPC) and the spindle pole body (SP

108 The molecular structure of the yeast nuclear pore complex (NPC) and the translocation of mode

109 generated nanobodies against the vertebrate nuclear pore complex (NPC) and used them in STORM imagin

110 e associated with shedding of NUP62 from the nuclear pore complex (NPC) and/or retention of NUP62 in

111 The cytoplasmic filament nucleoporins of the nuclear pore complex (NPC) are critically involved in nu

112 The nuclear pore complex (NPC) arose in evolution as the cel

113 However, how nuclear pore complex (NPC) barrier selectivity, Kap traf

114 The intricacy of nuclear pore complex (NPC) biogenesis imposes risks of f

115 Nup358, a late marker for interphase nuclear pore complex (NPC) biogenesis, is underrepresent

116 elusive mechanism of membrane fusion during nuclear pore complex (NPC) biogenesis.

117 ing; here we show that it is targeted to the nuclear pore complex (NPC) by binding an acidic face of

118 show that PfSR1 is localized adjacent to the Nuclear Pore Complex (NPC) clusters in the nucleus of ea

119 directly in vitro with the FG repeats of the nuclear pore complex (NPC) components Nup62, Nup98, and

120 Here, we show that nuclear pore complex (NPC) components Nup93 and Nup153 b

121 The nuclear pore complex (NPC) constitutes the sole gateway

122 While the static structure of the nuclear pore complex (NPC) continues to be refined with

123 The key component of the nuclear pore complex (NPC) controlling permeability, sel

124 The nuclear pore complex (NPC) controls the transport of mac

125 mechanism to explain how a component of the nuclear pore complex (NPC) could cause Htx/CHD was undef

126 These findings are attributed to nuclear pore complex (NPC) disintegration by nsp1beta, r

127 The nuclear pore complex (NPC) employs the intrinsically dis

128 esized membrane proteins traffic through the nuclear pore complex (NPC) en route to the inner nuclear

129 Here we tested if the nuclear pore complex (NPC) facilitates the targeting of

130 /RanGAP1*SUMO1/Ubc9 localizes at cytoplasmic nuclear pore complex (NPC) filaments and is a docking si

131 nterest and represents a central paradigm to nuclear pore complex (NPC) function, where nuclear trans

132 nucleocytoplasmic information transfer, the nuclear pore complex (NPC) has been studied in great det

133 The nuclear pore complex (NPC) has dual roles in nucleocytop

134 In recent years, the nuclear pore complex (NPC) has emerged as a key player i

135 The Nuclear Pore Complex (NPC) has emerged as an important h

136 l T cell signaling, direct regulation of the nuclear pore complex (NPC) has not been reported.

137 Interactions between the genome and the nuclear pore complex (NPC) have been implicated in multi

138 lluring proposal outlining functions for the nuclear pore complex (NPC) in transcription and nuclear

139 ential for the transport of mRNA through the nuclear pore complex (NPC) in yeast, but the molecular m

140 At the center of the nuclear pore complex (NPC) is a uniquely versatile centr

141 oporin 62 (Nup62), and as a consequence, the nuclear pore complex (NPC) is disintegrated and the nucl

142 The basket of the nuclear pore complex (NPC) is generally depicted as a di

143 nups) that line the transport channel of the nuclear pore complex (NPC) is investigated by means of c

144 Binding of the capsid to the nuclear pore complex (NPC) is mediated by the capsid pro

145 The nuclear pore complex (NPC) is responsible for nucleocyto

146 The nuclear pore complex (NPC) is the gate for transport bet

147 The nuclear pore complex (NPC) is the principal gateway for

148 The nuclear pore complex (NPC) is the proteinaceous nanopore

149 The prevailing model poses that the nuclear pore complex (NPC) is the sole gatekeeper for tr

150 The nuclear pore complex (NPC) mediates nucleocytoplasmic tr

151 Interference with the nuclear pore complex (NPC) or the actin cytoskeleton in

152 The nuclear pore complex (NPC) plays a critical role in gene

153 Tpr is a conserved nuclear pore complex (NPC) protein implicated in the spi

154 iated Esc1, the SUMO E3 ligase Siz2, and the nuclear pore complex (NPC) protein Nup170-physically and

155 enterovirus 2A protease directly cleaves the nuclear pore complex (NPC) protein, Nup98, at amino acid

156 ring Aspergillus nidulans mitosis peripheral nuclear pore complex (NPC) proteins (Nups) disperse from

157 Enteroviruses proteolyze nuclear pore complex (NPC) proteins (Nups) during infect

158 Loss of nuclear pore complex (NPC) proteins, transcription facto

159 SLiM-dependent proximity to centrosomal and nuclear pore complex (NPC) proteins-structures where Ca(

160 The nuclear pore complex (NPC) regulates transport between t

161 his process is regulated at the level of the nuclear pore complex (NPC) remains unclear.

162 in receptor (p75(NTR)) is a component of the nuclear pore complex (NPC) required for glial scar forma

163 Translocation of mRNA through the nuclear pore complex (NPC) requires interactions with di

164 Selective transport through the nuclear pore complex (NPC) requires nucleoporins contain

165 Lectin blockade of the nuclear pore complex (NPC) resulted in inhibition of nuc

166 The nuclear pore complex (NPC) selectively gates the transpo

167 The nuclear pore complex (NPC) serves as both the unique gat

168 The nuclear pore complex (NPC) serves as the sole bidirectio

169 The nuclear pore complex (NPC) solely mediates molecular tra

170 es for some ER proteins in the NE for proper nuclear pore complex (NPC) structure and function.

171 The nuclear pore complex (NPC) tethers chromatin to create a

172 We propose that NUP153 links the nuclear pore complex (NPC) to chromatin architecture all

173 nsport, however, is tightly regulated by the nuclear pore complex (NPC) with the hydrophobic transpor

174 novirus (AdV) to the cytoplasmic face of the nuclear pore complex (NPC), a key step during delivery o

175 the nuclear envelope (NE) is mediated by the nuclear pore complex (NPC), a massive ~100-MDa assembly

176 One such assembly is the nuclear pore complex (NPC), an ~50 MDa assembly comprise

177 tether transcriptionally active loci to the nuclear pore complex (NPC), and it also promotes large-s

178 etic modifiers that encode components of the nuclear pore complex (NPC), as well as the machinery tha

179 The nuclear pore complex (NPC), assembled from approximately

180 ls involves regulatory interactions with the nuclear pore complex (NPC), followed by translocation to

181 2, a component of the central channel of the nuclear pore complex (NPC), for forced dimerization by t

182 g, transport, and cytoplasmic release from a nuclear pore complex (NPC), is fast ( approximately 200

183 this study we used BioID to study the human nuclear pore complex (NPC), one of the largest macromole

184 ic reticulum to the Golgi apparatus, and the nuclear pore complex (NPC), which facilitates nucleo-cyt

185 Nuclear pore complex (NPC)-mediated nucleocytoplasmic tr

186 of a non-dividing cell, is exclusive to the nuclear pore complex (NPC).

187 Nucleoporins are essential components of the nuclear pore complex (NPC).

188 mammalian nucleoporin 98, a component of the nuclear pore complex (NPC).

189 rved assembly at the cytoplasmic face of the nuclear pore complex (NPC).

190 5, a core component of the inner ring of the nuclear pore complex (NPC).

191 repeats that fill the central channel of the nuclear pore complex (NPC).

192 hat localizes to the cytoplasmic side of the nuclear pore complex (NPC).

193 s) are exported to the cytoplasm through the nuclear pore complex (NPC).

194 o transport cargos directionally through the nuclear pore complex (NPC).

195 king site for protein-cargo complexes at the nuclear pore complex (NPC).

196 nslocation of transport complexes across the nuclear pore complex (NPC).

197 for unstructured proteins (polymers) in the nuclear pore complex (NPC).

198 lasmic transport is tightly regulated by the nuclear pore complex (NPC).

199 to and out of the nucleus occurs through the nuclear pore complex (NPC).

200 cleocytoplasmic transport events through the nuclear pore complex (NPC).

201 ontaining nucleoporin proteins (Nups) within nuclear pore complexes (NPC).

202 Nuclear pore complexes (NPCs) accumulate at TAN lines pr

203 Nuclear Pore complexes (NPCs) act as docking sites to an

204 Nuclear pore complexes (NPCs) allow selective import and

205 lasmic reticulum (ER), translocation through nuclear pore complexes (NPCs) and retention on nuclear p

206 ic systems such as Saccharomyces cerevisiae, nuclear pore complexes (NPCs) and the spindle pole body

207 eraction of non-chromosomal DNA circles with nuclear pore complexes (NPCs) and thereby promotes their

208 hp1:Sem1:Sus1:Cdc31 (TREX2) complex binds to nuclear pore complexes (NPCs) and, in addition to integr

209 Nuclear pore complexes (NPCs) are 110-megadalton assembl

210 Nuclear pore complexes (NPCs) are approximately 100 MDa

211 Nuclear pore complexes (NPCs) are composed of several co

212 embranes coupled to the selective barrier of nuclear pore complexes (NPCs) are essential for the segr

213 Nuclear pore complexes (NPCs) are essential protein asse

214 Nuclear pore complexes (NPCs) are huge assemblies formed

215 Nuclear pore complexes (NPCs) are important for cellular

216 Nuclear Pore Complexes (NPCs) are key cellular transport

217 Nuclear pore complexes (NPCs) are large macromolecular a

218 Nuclear pore complexes (NPCs) are large macromolecular s

219 long-term protein persistence, we found that nuclear pore complexes (NPCs) are maintained over a cell

220 Nuclear pore complexes (NPCs) are multiprotein channels

221 Nuclear pore complexes (NPCs) are the main conduits for

222 e nucleus, possibly due to delocalization of nuclear pore complexes (NPCs) at the nuclear envelope.

223 Nuclear pore complexes (NPCs) conduct massive transport

224 Nuclear pore complexes (NPCs) conduct selective, bidirec

225 The transport channel of nuclear pore complexes (NPCs) contains a high density of

226 The permeability barrier of nuclear pore complexes (NPCs) controls bulk nucleocytopl

227 Transport through nuclear pore complexes (NPCs) during interphase is facil

228 es but also on its binding to Megator/Tpr at nuclear pore complexes (NPCs) during interphase.

229 of mitosis and modulates distribution of the nuclear pore complexes (NPCs) during mitotic NE expansio

230 Nucleocytoplasmic transport is mediated by nuclear pore complexes (NPCs) embedded in the nuclear en

231 Nuclear pore complexes (NPCs) emerged as nuclear transpo

232 Nuclear pore complexes (NPCs) form a selective filter th

233 Nuclear pore complexes (NPCs) form gateways for material

234 Oocytes stockpile nuclear pore complexes (NPCs) in cytoplasmic membrane sh

235 Here we show that nuclear pore complexes (NPCs) in interphase cells also f

236 es can lead to an uneven distribution of the nuclear pore complexes (NPCs) in the interphase nuclear

237 Here, we have shown that during mitosis nuclear pore complexes (NPCs) in the mother nucleus are

238 Nuclear pore complexes (NPCs) influence gene expression

239 The interior of nuclear pore complexes (NPCs) is densely filled with FG-

240 artmentalization by the nuclear envelope and nuclear pore complexes (NPCs) is essential for cell func

241 epletions suggest that translocation through nuclear pore complexes (NPCs) is rate-limiting and restr

242 Passive macromolecular diffusion through nuclear pore complexes (NPCs) is thought to decrease dra

243 cleus and cytoplasm, is tightly regulated by nuclear pore complexes (NPCs) made up of nucleoporins (N

244 Nuclear pore complexes (NPCs) mediate cargo traffic betw

245 Nuclear pore complexes (NPCs) mediate nucleocytoplasmic

246 Nuclear pore complexes (NPCs) mediate the exchange of ma

247 er RNA:protein complexes (mRNPs) through the nuclear pore complexes (NPCs) of eukaryotic cells.

248 Nuclear pore complexes (NPCs) perforate the nuclear enve

249 Nuclear pore complexes (NPCs) regulate all cargo traffic

250 nuclear envelope (NE) is densely packed with nuclear pore complexes (NPCs) that are stockpiled for em

251 Chromatin and nuclear pore complexes (NPCs) undergo dramatic changes d

252 to p53-SUMO-1 and their accumulation in the nuclear pore complexes (NPCs), as well as their persiste

253 GANP is required to recruit ENY2 to nuclear pore complexes (NPCs), but ENY2 is not necessary

254 horylation-driven partial disassembly of the nuclear pore complexes (NPCs), increasing their permeabi

255 ucleocytoplasmic transport are maintained by nuclear pore complexes (NPCs), large structures composed

256 known as the constituent building blocks of nuclear pore complexes (NPCs), membrane-embedded channel

257 ucleocytoplasmic transport is facilitated by nuclear pore complexes (NPCs), which are massive protein

258 selective and efficient biomachines known as nuclear pore complexes (NPCs).

259 nuclei showed a round shape and presence of nuclear pore complexes (NPCs).

260 ar envelope, so Mad1 does not anchor them to nuclear pore complexes (NPCs).

261 when tRNA synthesis peaks, tDNAs localize at nuclear pore complexes (NPCs).

262 nucleocytoplasmic transport (NCT) to bypass nuclear pore complexes (NPCs).

263 les and contribute to the quality control of nuclear pore complexes (NPCs); whether these processes a

264 air; neuron pruning; extraction of defective nuclear pore complexes; nuclear envelope reformation; pl

265 sample preservation with a structure of the nuclear pore complex obtained from a single tomogram.

266 Because NIMA triggers nuclear pore complex opening during mitosis, our finding

267 uding capsid transport, decapsidation at the nuclear pore complex, particle assembly, and secondary e

268 rins implicated in maintaining the selective nuclear pore complex permeability barrier.

269 Our finding suggested that the nuclear pore complex plays an important role in mammalia

270 Here we review transport through the nuclear pore complex, pointing out vulnerabilities that

271 The nuclear pore complex protein NUP88 is frequently elevate

272 that the Arabidopsis (Arabidopsis thaliana) nuclear pore complex protein Nup88/MOS7 is essential for

273 itionally revealed interactions with several nuclear pore complex proteins by proteomics analysis.

274 Kee et al. now propose that nuclear pore complex proteins form a fundamental part of

275 duals, while the total number and density of nuclear pore complexes remained normal.

276 RNAs from the nucleus to the cytosol through nuclear pore complexes represents an important step in t

277 eraction partners of VAPB at the INM and the nuclear pore complex, respectively.

278 Analysis of a large dynamic structure-the nuclear pore complex-revealed variations detectable at t

279 itulate "dilation" and "constriction" of the nuclear pore complex's central transport channel.

280 subset of 8, including key components of the nuclear pore complex scaffold and the transmembrane nucl

281 Rodriguez-Bravo et al. report that the nuclear pore complex scaffolds spindle assembly checkpoi

282 Beyond their role at nuclear pore complexes, some nucleoporins function in th

283 provided a high-resolution understanding of nuclear pore complex structure and transport, revealing

284 Depletion of nuclear pore complex subunits in the context of POT1 dys

285 ld-type full-length NUP98 is a member of the nuclear pore complex, the chromosomal translocations lea

286 ssical nuclear import pathway, involving the nuclear pore complex, the small GTPase Ran, and cellular

287 Within the nuclear pore complex, this underlies how transport recep

288 human cells, this dynein pool is anchored to nuclear pore complexes through RanBP2-Bicaudal D2 (BICD2

289 Nuclear pore complexes tightly regulate nucleo-cytoplasm

290 rate complicated molecular gates such as the nuclear pore complex to control the transport of biologi

291 mprehensive architectural model of the human nuclear pore complex to date.

292 ion of identical daughter nuclei by coupling nuclear pore complexes to the segregating chromosomes.

293 onsiderations when studying the mechanism of nuclear pore complex transport in vivo.

294 onal hsp-16.2/41 promoter interacts with the nuclear pore complex upon activation by heat shock in th

295 entary studies that Plk1 is recruited to the nuclear pore complex upon mitotic entry, where it acts w

296 the cellular substrates, particularly in the nuclear pore complex, used by these proteases were indee

297 cking and translocation of mRNAs through the nuclear pore complex via interactions with nucleoporins(

298 oscopy (AFM) to the nuclear envelope and the nuclear pore complexes, we demonstrate that disposition

299 ants, and 3) transcripts being enriched near nuclear pore complexes when components of the mRNA expor

300 ins (NUPs) are an essential component of the nuclear-pore complex, which regulates nucleocytoplasmic