ライフサイエンスコーパス: nuclear receptor

1 orted by an evolutionarily conserved type of nuclear receptor.

2 d binding, leading to the designation orphan nuclear receptor.

3 ding structural evidence of ligand bias in a nuclear receptor.

4 ng an interaction between this bile acid and nuclear receptor.

5 are capable of binding and activating these nuclear receptors.

6 tors (NR4A1-3) belongs to the superfamily of nuclear receptors.

7 ), known to be regulated by ligand-activated nuclear receptors.

8 of Th17 cells through the activation of NR4A nuclear receptors.

9 environmental sensing as a novel function of nuclear receptors.

10 m the transcriptional action of estrogens on nuclear receptors.

11 oupled receptors, kinases, ion channels, and nuclear receptors.

12 ayer, alpha-helical ligand-binding domain of nuclear receptors.

13 BAs and express high levels of BA-sensitive nuclear receptors.

14 tabolites that can directly bind to multiple nuclear receptors.

15 usceptibility to inflammatory colitis via BA nuclear receptors.

16 ment or spontaneously in diabetic livers via nuclear receptors.

17 Nuclear receptor 2f1 (Nr2f1) and nuclear receptor 2f2 (N

18 Nuclear receptor 2f1 (Nr2f1) and nuclear receptor 2f2 (Nr2f2) in addition to Meis homeobo

19 tension of the molecular switch model of the nuclear receptor action is proposed.

20 Liver X receptors (LXRs) are nuclear receptors activated by oxidized lipids and were

21 at the abilities of FASN and MAGL to promote nuclear receptor activation and PCa metastasis are criti

22 Molecular pathways related to nuclear receptor activation, ECM turnover, and lipid bio

23 s, we replicated several genes implicated in nuclear receptor activations, acute phase response pathw

24 These changes are partially independent of nuclear receptor activity but, in the case of TNF-alpha

25 to quantitatively screen for chemicals with nuclear receptor activity in environmental samples.

26 Here, we show that the dHNF4 nuclear receptor acts at the onset of Drosophila adultho

27 egulates apoA-IV gene expression through its nuclear receptor alpha (ERalpha), which requires co-acti

28 17beta-estradiol (estrogen) through its two nuclear receptors, alpha and beta (ERalpha, ERbeta), is

29 FXR controls bile acid homeostasis, but both nuclear receptors also regulate numerous other metabolic

30 Rev-erbalpha is a ligand-dependent nuclear receptor and a key repressor of the molecular cl

31 Here we demonstrate that Rev-erbalpha, a nuclear receptor and circadian clock component, is a med

32 to function as a physiological ligand for a nuclear receptor and direct environmental sensing as a n

33 The mineralocorticoid receptor (MR) is a nuclear receptor and part of a large and diverse family

34 ator comprises high selectivity over related nuclear receptors and activates the two target transcrip

35 We found an enrichment of nuclear receptors and confirmed their role in cytokine r

36 how that liver X receptors (LXRs)-a class of nuclear receptors and transcription factors with diverse

37 ol metabolism and energy balance via several nuclear receptors and/or G-protein-coupled receptors(3,4

38 otein targets: sEH (a hydrolase), ERalpha (a nuclear receptor), and c-KIT (a kinase).

39 s conceptually new, unique for this specific nuclear receptor, and offers advantages over traditional

40 Nuclear receptors are a family of transcription factors

41 s) are poorly defined, despite the fact that nuclear receptors are a major drug target.

42 receptors decreased in Atp7b (-/-) mice, and nuclear receptors are critical for maintaining metabolic

43 Furthermore, nuclear receptors are encoded in the genomes of primitiv

44 The NR5A-family nuclear receptors are highly conserved and function with

45 As nuclear receptors are targets for both TPHP and TDCIPP,

46 NR4A nuclear receptors are tumor suppressors of AML that func

47 ferator-activated receptor-gamma (PPARgamma) nuclear receptor, are potent stimuli for adipocyte brown

48 Most transcription factors, including nuclear receptors, are widely modeled as binding regulat

49 arachidonic acid, thus providing ligands for nuclear receptors as key regulators of hepatic bile acid

50 that implicates DAF-12 and potentially other nuclear receptors as novel anthelmintic targets.

51 expression of members of the NR4A family of nuclear receptors, as well as Prdm1 and Xbp1 While delet

52 ated orphan receptor gammat (RORgammat) is a nuclear receptor associated with the pathogenesis of aut

53 lated the transcriptional activity of tested nuclear receptors at environmentally relevant concentrat

54 the current advances of clinical trials for nuclear receptor-based cancer therapeutics.

55 Histone methyltransferases of the nuclear receptor-binding SET domain protein (NSD) family

56 tes in cortical chromatin, we show that this nuclear receptor binds both differentially expressed ene

57 The nuclear receptor CAR (NR1I3) regulates hepatic drug and

58 to prototypical P450 inducers, expression of nuclear receptors CAR and pregnane X receptor, and struc

59 We examined whether a nuclear receptor cascade involving FXR and FXR-induced s

60 VEGF-C is negatively regulated by an orphan nuclear receptor, chicken ovalbumin upstream promoter-tr

61 gene in Ishikawa cells, we demonstrate that nuclear receptor co-activator 6 (NCOA6) is essential for

62 Nuclear receptor co-activator peroxisome proliferator-ac

63 irectly facilitates its interaction with the nuclear receptor co-repressor (NCoR1), resulting in repr

64 Here we show that the specific deletion of nuclear receptor co-repressor 1 (NCoR1) in T cells cause

65 NA-seq in human reticulocytes and identified nuclear receptor coactivator 4 (NCOA4) as a critical reg

66 NCOA4 (nuclear receptor coactivator 4) is a widely expressed in

67 ith higher affinity than to the coactivator, nuclear receptor coactivator-2 (Tif2), in coregulator pe

68 we report that heterozygous deletion of the nuclear receptor coactivator-5 (Ncoa5) gene resulted in

69 fferent coactivator activities to engage the nuclear receptor complex at different steps of transcrip

70 The Nr4a subfamily of nuclear receptor comprises three members in mammalian ce

71 Pregnane X receptor (PXR) is a nuclear receptor considered to be a master xenobiotic re

72 athway suppressor 2 (GPS2), a subunit of the nuclear receptor corepressor (NCOR) and histone deacetyl

73 the interaction of the MeCP2 with DNA or the nuclear receptor corepressor (NCoR)/silencing mediator o

74 Moreover, targeted inhibition of BCL6/nuclear receptor corepressor 1 (NCoR) complex by peptido

75 Nuclear receptor corepressor 1 (NCOR1) and NCOR2 (also k

76 Nuclear receptor corepressor 1 (NCoR1) and silencing med

77 study, we report that deletion of intestinal nuclear receptor corepressor 1 (NCoR1) completely dimini

78 Nuclear receptor corepressor 1 (NCoR1) is considered to

79 ction with the histone deacetylase 3 (HDAC3)-nuclear receptor corepressor 1 (NCoR1) repressor complex

80 The nuclear receptor corepressor 1 (NCOR1) was reported to m

81 due to loss of glucose homeostasis regulator nuclear receptor corepressor 2 repression, and chromatin

82 via downregulation of the tumor-suppressive nuclear receptor corepressor NCOR1.

83 Nuclear receptor corepressors (NCORs) are transcription

84 em, HDAC3 is unique in that interaction with nuclear receptor corepressors 1 and 2 (NCoR1/2) is requi

85 strogen-related receptor beta (ERRbeta) is a nuclear receptor critical for many biological processes.

86 NR1H3 and Lxrbeta/NR1H2 are ligand-dependent nuclear receptors critical for midbrain dopaminergic (mD

87 The activity of several nuclear receptors decreased in Atp7b (-/-) mice, and nuc

88 e effects of SUMOylation on other classes of nuclear receptors, dexamethasone (Dex)-induced trans-rep

89 et al. (2018) show that the Drosophila HNF4 nuclear receptor drives adults to convert lipids to very

90 or-activated receptor gamma (PPARgamma) is a nuclear receptor essential for adipocyte development and

91 to better understand the mechanisms of these nuclear receptors, evaluate their synergistic pathways a

92 elated receptor beta (ERR-beta) is an orphan nuclear receptor expressed in the brain, where alternati

93 nr4A encodes a nuclear receptor expressed predominantly in planarian mu

94 The fatty acid sensing nuclear receptor families retinoid X receptors (RXRs) an

95 ors (LXR) are transcription factors from the nuclear receptor family that are activated by oxysterols

96 R4A3 is a transcription factor of the orphan nuclear receptor family.

97 ranscriptional coactivator of the BA-sensing nuclear receptor farnesoid X receptor (FXR) and epigenet

98 ed cell-intrinsic responses dependent on the nuclear receptor Farnesoid X Receptor (FXR).

99 Nuclear receptors farnesoid X receptor (FXR) and small h

100 The bile acid (BA) nuclear receptor, farnesoid X receptor (FXR/NR1H4), main

101 We show that transcription induced by nuclear receptors for estrogen (E(2)) or retinoic acid (

102 discovered to be endogenous ligands for the nuclear receptor FXR.

103 factor Retineic acid receptor-related orphan nuclear receptor gamma (RORgammat) and Forkhead box prot

104 (AhR)-retinoic acid receptor-related orphan nuclear receptor-gammat (ROR-gammat) complex formation.

105 rneurons (INs) expressing the RORbeta orphan nuclear receptor gate sensory feedback to the spinal mot

106 ing-induced expression of the CREB-regulated nuclear receptor gene Nr4a2 is selectively impaired in a

107 tor (RXR), PPARgamma binds directly repeated nuclear receptor half sites spaced by one nucleotide (di

108 The TR4 nuclear receptor has been reported to play an important

109 Nuclear receptors have a broad spectrum of biological fu

110 s well-known therapeutic targets in mammals, nuclear receptors have begun to be studied in parasitic

111 roperties of druggability and actionability, nuclear receptors have demonstrated much promise as nove

112 Despite intensive efforts, most nuclear receptors have no known ligand, suggesting new l

113 ranscriptional targets of the PPAR family of nuclear receptors, Hdac3 deletion enhances their inducti

114 The repressive states of nuclear receptors (i.e., apo or bound to antagonists or

115 scular pleiotropic effects by activating its nuclear receptor in cardiomyocytes and vascular endothel

116 myelitis (EAE), highlighting a role for this nuclear receptor in limiting the development of CNS infl

117 Here, we summarize the roles of nuclear receptors in cancer biology and tumor immunology

118 haracterize a crucial role for retinoic acid nuclear receptors in controlling exit from the regenerat

119 re, we discover that Ftz-f1, one of the NR5A nuclear receptors in Drosophila, is transiently induced

120 Here, we focus on the role of nuclear receptors in podocyte biology and non-diabetic g

121 in Drosophila and the conserved role of NR5A nuclear receptors in regulating folliculogenesis and ovu

122 tastatic process and establish lipid-sensing nuclear receptors in the microenvironmental regulation o

123 s highlighted the essential roles of certain nuclear receptors in tumor immunology, suggesting the po

124 tools to study the role and interplay of the nuclear receptors in various pathologies.

125 Here we identify nhr-14, encoding a nuclear receptor, in a screen conducted for mutations th

126 on to a lipid-rich diet, mediated largely by nuclear receptors including Hnf4alpha, relied on activat

127 ch C-terminus of ARGLU1 coactivates multiple nuclear receptors including the glucocorticoid receptor

128 s in the liver that are modulated by several nuclear receptors, including peroxisome proliferator-act

129 Most ligand bound structures of nuclear receptors, including peroxisome proliferator-act

130 ption as part of a heterodimer with 14 other nuclear receptors, including the peroxisome proliferator

131 We previously showed that Nur77, an orphan nuclear receptor, induces apoptosis by targeting mitocho

132 ting mutation (c.279delG, p.Trp93fs*) of the nuclear receptor interacting protein 1 gene (NRIP1) in a

133 Furthermore, disruption of the LXXLL nuclear receptor-interacting motif present in ACTN4 resu

134 tein activator receptor gamma (PPARgamma), a nuclear receptor involved in inflammatory responses.

135 es suggested that differential expression of nuclear receptors involved in adipogenesis underlie the

136 liminarily been identified as a modulator of nuclear receptors involved in beta-amyloid (Abeta) metab

137 human target datasets constituting enzymes, nuclear receptors, ion channels, and G-protein-coupled r

138 One such nuclear receptor is DAF-12, which is required for normal

139 We found that no single TH nuclear receptor is required for TH-mediated induction o

140 ed that NHR-6, the sole C. elegans NR4A-type nuclear receptor, is required for BAG-mediated avoidance

141 (PXR, NR1I2), a member of the superfamily of nuclear receptors, is a transcription factor governing t

142 he Liver-X-Receptors (LXRalpha and LXRbeta), nuclear receptors known to regulate lipid metabolism and

143 s to TDCIPP in the presence or absence of 69 nuclear receptor ligands and, similar to TPHP, found tha

144 r results point to a complex interplay among nuclear receptor ligands, cytosine methylation, and the

145 The nuclear receptor liver receptor homolog 1 (LRH-1) is an

146 f action of RJW100, a racemic agonist of the nuclear receptors liver receptor homolog-1 (LRH-1) and s

147 The nuclear receptor LXR is necessary for Srebf-1c transcrip

148 ating intracellular cholesterol homeostasis, nuclear receptor LXR-alpha was up-regulated significantl

149 Liver X nuclear receptor (LXR) agonists are promising anti-ather

150 Here we found TR4 nuclear receptor might alter the sunitinib resistance to

151 t directs the biodistribution of parent drug nuclear receptor modulators into the CNS while masking t

152 vious studies identified small-molecule NR4A nuclear receptor modulators, but it remains unclear if t

153 Nuclear receptor modulators, which often feature carboxy

154 Here the authors show that the nuclear receptor NCoR1 suppresses Bim1 to inhibit negati

155 the reduction of pro-inflammatory mediators, nuclear receptor NF-kappaB expression and gastric mucosa

156 Our results show that farnesol modulates nuclear receptors, NF-kappaB, and MAPK-signaling pathway

157 into the nucleus to activate lipid regulated nuclear receptors NHR-49 and NHR-80 and consequently pro

158 Following the first isolation of nuclear receptor (NR) genes, genetic disorders caused by

159 nd allosteric communications in multi-domain nuclear receptor (NR) polypeptides has remained challeng

160 Members of the nuclear receptor (NR) superfamily orchestrate cellular p

161 Members of the nuclear receptor (NR) superfamily regulate both physiolo

162 Nuclear receptor (NR) transcription factors use a conser

163 ain-2 (AF-2) is a primary contributor to the nuclear receptor (NR) transcriptional activity.

164 The pregnane X receptor (PXR) is a nuclear receptor (NR), involved in the detoxification of

165 We further report the characterization of a nuclear receptor (NR), which we call Vitellogenic Factor

166 to form domain-domain interactions with DBDs.Nuclear receptors (NR) are multidomain proteins, which m

167 reatment of fibroblasts activates the orphan nuclear receptor NR4A (Nur77), with prolactin as a major

168 These findings show that the orphan nuclear receptor NR4A1 controls PD-L1 expression and ide

169 xpression of phagocytosis receptor Mertk and nuclear receptor Nr4a1 in cardiac macrophages, the latte

170 this study, we report overexpression of the nuclear receptor NR4A1 in rhabdomyosarcomas that is suff

171 cells, PD-L1 expression was regulated by the nuclear receptor NR4A1/Sp1 complex bound to the proximal

172 Nuclear receptors (NRs) are high-interest targets in dru

173 Nuclear receptors (NRs) are transcription factors that r

174 Nuclear receptors (NRs) form homo- and/or heterodimers a

175 The type II nuclear receptors (NRs) function as heterodimeric transc

176 Nuclear receptors (NRs) have historically been at the fo

177 Nuclear receptors (NRs) sense changing levels of nutrien

178 An important target of EDCs is nuclear receptors (NRs) that control endocrine and metab

179 The nuclear receptors (NRs), NR2F2 and NR2C2, can bind to (T

180 rodimerization partner for at least 20 other nuclear receptors (NRs).

181 oreign Ags express high levels of the orphan nuclear receptor Nur77, which is known to be upregulated

182 horylated Spleen tyrosine kinase (pSyk), and nuclear receptor Nur77.

183 The orphan nuclear receptor Nurr1 (also known as NR4A2) is an essen

184 d after exercise in mice revealed the orphan nuclear receptor NURR1/NR4A2 as a prominent component of

185 ing to the glucocorticoid receptor (GR), the nuclear receptor of endogenous cortisol.

186 g the main biological process, and canonical nuclear receptor pathways as their potential mediators.

187 ng the main biological process and canonical nuclear receptor pathways as their potential mediators.

188 re induces the expression of the steatogenic nuclear receptor peroxisome proliferator-activated gamma

189 ion of the genes involved in the steatogenic nuclear receptor peroxisome proliferator-activated gamma

190 Nuclear receptor peroxisome proliferator-activated recep

191 type-2 diabetes that binds and activates the nuclear receptor peroxisome proliferator-activated recep

192 e agonists on the conformational ensemble of nuclear receptor peroxisome proliferator-activated recep

193 tic drugs through their direct action on the nuclear receptor peroxisome proliferator-activated recep

194 Here we identify the nuclear receptor peroxisome proliferator-activated recep

195 During fasting, activation of the nuclear receptor peroxisome proliferator-activated recep

196 The nuclear receptor PPAR-beta/delta (PPARD) has essential r

197 uclear localization and interaction with the nuclear receptor PPARalpha to transcriptionally activate

198 These lipids are endogenous ligands for the nuclear receptor PPARalpha, and we demonstrate that Ppar

199 ted by the transcription factor ATF4 and the nuclear receptor PPARalpha, which participate in the tra

200 The nuclear receptors PPARalpha (encoded by NR1C1) and farne

201 nge the presumption that the function of the nuclear receptor PPARbeta/delta in cancer is dictated by

202 The nuclear receptor Pparg promotes urothelial differentiati

203 The PPARG gene encoding the nuclear receptor PPARgamma is activated in bladder cance

204 racellular domain of Lrp1 interacts with the nuclear receptor Ppargamma, a central regulator of lipid

205 or the lipid scavenger receptor CD36 and the nuclear receptor PPARgamma.

206 Ag-presenting glycoprotein CD1d through the nuclear receptors PPARgamma and RARalpha, as well as p38

207 We identify lipid-activated nuclear receptors PPARs as potential mediators of the ef

208 lters CYP3A4 expression by activation of the nuclear receptor pregnane X receptor (PXR).

209 dial hypothalamus (VMHdm/c) that express the nuclear receptor protein NR5A1 (also known as SF1) are n

210 Accumulation of PIP3 in complex with the nuclear receptor protein, SF1, at damage sites requires

211 4, a cytochrome P450 enzyme regulated by the nuclear receptor PXR, is involved in most of the drug me

212 Thus, our study suggests that nuclear receptor RARgamma provides a key checkpoint for

213 Nuclear receptors recruit multiple coactivators sequenti

214 Here we report that Nuclear receptor-related 1 (Nurr1):Retinoid X receptor a

215 Here, the authors show that the nuclear receptor retinoic acid receptor gamma is release

216 rising residues Gln275, Arg316 and Arg371 in nuclear receptor retinoid X receptor alpha (RXRalpha), w

217 usly reported that selective ablation of the nuclear receptors retinoid X receptor (RXR)-alpha and RX

218 The nuclear receptor REV-ERB suppresses myoblast differentia

219 hythmic transcription of genes including the nuclear receptor REV-ERBalpha, which represses BMAL1 and

220 The nuclear receptors REV-ERBalpha and -beta link circadian

221 Like other nuclear receptors, REV-ERB activity can be regulated by

222 The nuclear receptor REVERBalpha is a core component of the

223 ere we show that liver-specific depletion of nuclear receptors RORalpha and RORgamma, key components

224 methyl substrates-an inverse agonist for the nuclear receptor RORc and an antagonist of the sphingosi

225 synthesis program that is strongly linked to nuclear receptor RORgamma, compared to estrogen receptor

226 on the retinoic acid receptor-related orphan nuclear receptor RORgammat.

227 Intriguingly, although it is known as a nuclear receptor, RXRB shows a prominent cell surface lo

228 Inhibiting the nuclear receptor's activity using a chemical antagonist

229 A subset of cardiac-enriched nuclear receptors serve to match mitochondrial fuel pref

230 The orphan nuclear receptor SHP (small heterodimer partner) is a we

231 Substantial evidence indicates that nuclear receptor signaling is integral to dynamic change

232 lterations in hepatic metabolic profiles and nuclear receptor signaling were associated with improved

233 cytosolic lipid metabolism to pro-metastatic nuclear receptor signaling.

234 thogenic molecular pathways elicited by this nuclear receptor.Significance: These findings challenge

235 The nuclear receptor small heterodimer partner (Shp) plays a

236 dafachronic acid, an agonist of the parasite nuclear receptor Ss-DAF-12, significantly reduced the wo

237 The nuclear receptor steroidogenic factor 1 (Sf1, Nr5a1, Ad4

238 Our findings highlight that nuclear receptor structure and function are dictated by

239 structure and also one of only a few unknown nuclear receptor structures.

240 The nuclear receptor subfamily 0 group B member 2 (NR0B2, al

241 nvestigated whether the core clock component nuclear receptor subfamily 1 group D member 1 (NR1D1, al

242 BACKGROUND & AIMS: The nuclear receptor subfamily 1 group H member 4 (NR1H4 or

243 The nuclear receptor subfamily 1 group H member 4 (NR1H4, al

244 Here, we demonstrate that nuclear receptor subfamily 2 group E member 3 (NR2E3) pl

245 ent increases mRNA and protein expression of nuclear receptor subfamily 2 group F member 6, whereas t

246 Computational analysis revealed that NR2F2 (nuclear receptor subfamily 2, group F, member 2) sites w

247 High levels of methylation in the GR gene (nuclear receptor subfamily 3, group C, member 1; NR3C1)

248 TC1-dependent transcription of c-fos and the nuclear receptor subfamily 4 (Nr4a) genes Nr4a1-3 in the

249 ese effects with an emphasis on TGF-beta and nuclear receptor subfamily 4 group A member 1 (NR4A1) si

250 The transcription factor Nur77 (Nr4a1 [nuclear receptor subfamily 4 group A member 1]) mediates

251 SCPP gene cluster to the region upstream of Nuclear Receptor Subfamily 4 Group A Member 3 (NR4A3) at

252 Down syndrome critical region 1 (Dscr1) and Nuclear receptor subfamily 4, group A, member 3 (Nr4a3)

253 arnesoid X receptor (FXR) is a member of the nuclear receptor superfamily of bile acid-activated tran

254 ion of the liver X receptors, members of the nuclear receptor superfamily of transcription factors, b

255 eric association with several members of the nuclear receptor superfamily, including the human vitami

256 humans, leading to the identification of the nuclear receptor superfamily.

257 vated transcription factor and member of the nuclear receptor superfamily.

258 ome during gene activation by ligands of the nuclear receptor superfamily.

259 The farnesoid X receptor (FXR) is a nuclear receptor that acts as a master regulator of bile

260 eceptor-related receptor alpha (ERRalpha), a nuclear receptor that cooperates with the transcription

261 Farnesoid X receptor (FXR) is a nuclear receptor that has emerged as a key regulator in

262 eceptor (PXR, NR1I2) is a xenobiotic-sensing nuclear receptor that modulates the metabolic response t

263 te the glucocorticoid receptor, a ubiquitous nuclear receptor that not only causes widespread changes

264 elated orphan receptor gamma (RORgamma) is a nuclear receptor that plays an essential role in the dev

265 eptor gamma (PPAR-gamma), a ligand-activated nuclear receptor that promotes vasorelaxation by increas

266 RORgammat is an important nuclear receptor that regulates the production of severa

267 s in NR2F1, which encodes a highly conserved nuclear receptor that serves as a transcriptional regula

268 pal among these is NR0B1, an atypical orphan nuclear receptor that we show engages in a multimeric pr

269 Nr4a1-3 encode a small family of orphan nuclear receptors that are rapidly induced by B cell ant

270 (Nr4a1) belongs to a small family of orphan nuclear receptors that are rapidly induced by BCR stimul

271 vity.IMPORTANCE Liver X receptors (LXRs) are nuclear receptors that mediate cholesterol and fatty aci

272 many physiological processes through either nuclear receptors that modulate gene expression or membr

273 Consequently, EP300 is redirected away from nuclear receptors that promote differentiation towards b

274 ndrome, as RXR heterodimerizes with multiple nuclear receptors that regulate genes involved in metabo

275 nt absorption and are endogenous ligands for nuclear receptors that regulate lipid and energy metabol

276 demonstrated by the screening on a panel of nuclear receptors, the assessment of the physical and th

277 rmones that regulate homeostasis through two nuclear receptors, the glucocorticoid receptor (GR) and

278 For most nuclear receptors, the ligand-dependent activation funct

279 orylated ERalpha signaling enables these two nuclear receptors to communicate, activating the Sult1e1

280 demonstrate that MVI directly interacts with nuclear receptors to drive expression of target genes, t

281 lular chaperone that delivers fatty acids to nuclear receptors to enhance PCa metastasis.

282 inoid acid receptor-related orphan receptor) nuclear receptors to potentiate circadian oscillation an

283 ses in many organs, where they interact with nuclear receptors to regulate gene transcription.

284 Our data reveal how C. elegans utilizes nuclear receptors to regulate innate immunity and iron a

285 Nurr1/NR4A2 is an orphan nuclear receptor transcription factor implicated as a dr

286 ubin functions as a molecular switch for the nuclear receptor transcription factor peroxisome prolife

287 death were not dependent on PXR, which is a nuclear receptor transcription factor that plays a cruci

288 brafish with mutations in the three known TH nuclear receptor transcription factors (thraa, thrab, an

289 ity, associated with secondary activation of nuclear receptor transcription factors NR4A1 (also known

290 actor 4 (HNF4) is the most ancient family of nuclear receptor transcription factors with important ro

291 e of dietary vitamin A, acts as a ligand for nuclear receptor transcription factors with more than 50

292 which competitive recruitment of DNA-binding nuclear receptors/transcription factors in trans to hot

293 NRIP1 encodes a nuclear receptor transcriptional cofactor that directly

294 and a high-throughput, fluorescent imaging, nuclear receptor translocation assay.

295 hormone (TH) due to its high affinity for TH nuclear receptors (TRs), new data suggest that 3,5-diiod

296 Nuclear receptor tyrosine kinases (nRTKs) are aberrantly

297 (BBB) and its upregulation by the vitamin D nuclear receptor (VDR) could provide an alternative rout

298 Expression of CD69 and NR4A nuclear receptors was evaluated by reverse transcription

299 Nuclear receptors were originally defined as endocrine s

300 ecdysone controls gene expression through a nuclear receptor, which functions as a ligand-dependent