ライフサイエンスコーパス: nuclear cataract

1 7.1%) of the optometrists could not identify nuclear cataract.

2 of inner mature fiber cells led to the dense nuclear cataract.

3 n of crystallin proteins correlated with the nuclear cataract.

4 Lp82/85, which results in the formation of a nuclear cataract.

5 ss may be involved in the formation of human nuclear cataract.

6 a strikingly high incidence of postsurgical nuclear cataract.

7 f the vitreous gel may protect patients from nuclear cataract.

8 t of five examined, that was associated with nuclear cataracts.

9 Cx50-null mice exhibited microphthalmia and nuclear cataracts.

10 utophagy and apoptosis and thence congenital nuclear cataracts.

11 M) patients with moderate NPDR and grade 2-3 nuclear cataracts.

12 ic index (dGI), and the risk of cortical and nuclear cataracts.

13 nvironment in the eye protects the lens from nuclear cataracts.

14 bodies (MLBs), reported in human age-related nuclear cataracts.

15 en has been proposed to be a risk factor for nuclear cataracts.

16 tween elevated oxygen levels and the risk of nuclear cataracts.

17 lar to the size of aggregates found in human nuclear cataracts.

18 reous gel during aging increases the risk of nuclear cataracts.

19 connexin (Cx)50 produces microphthalmia with nuclear cataracts.

20 is associated with the rapid progression of nuclear cataracts.

21 5% confidence interval (CI): 0.91, 2.99) for nuclear cataract, 1.62 (95% CI: 0.92, 2.85) for cortical

22 The OR for nuclear cataract (366 eyes) comparing the third quartile

23 istent with a genetic effect for age-related nuclear cataract, a common and clinically significant fo

24 Nuclear cataract, an advanced stage of nuclear sclerosis

25 PXS is associated with an increased risk of nuclear cataract and cataract surgery.

26 Cross-sectional nuclear cataract and dietary measurements were available

27 dds ratio for siblings for affectedness with nuclear cataract and the sibling correlation of nuclear

28 Thick sections from human nuclear cataracts and aged normal lenses were stained wi

29 expressing connexin50D47A (Cx50D47A) exhibit nuclear cataracts and impaired differentiation.

30 Phenotypically, bs mice exhibit nuclear cataracts and male infertility; genetic analyses

31 There seems to be no role in nuclear cataract, and any role in cortical or posterior

32 ge, sex (male), cortical cataract, diabetes, nuclear cataract, and former cigarette smoking were rela

33 ition, slit lamp photographs were graded for nuclear cataracts, and retroillumination photographs wer

34 Age-related nuclear cataracts are associated with progressive post-s

35 of the changes observed in human age-related nuclear cataract (ARNC).

36 Homozygous mutant mice developed dense nuclear cataracts associated with disrupted inner lens f

37 ere we present an intriguing case of a human nuclear cataract-associated mutant of HGD--namely Glu107

38 ietary vitamin C was protective against both nuclear cataract at baseline and nuclear cataract progre

39 nutrient supplements were protective against nuclear cataract at baseline only (beta = -0.009, P = 0.

40 suggested genetic influences on age-related nuclear cataract but few genetic markers have been ident

41 elieved to play a role in the development of nuclear cataract, but little is known regarding the rela

42 ting at 4 months that progressed into severe nuclear cataract by 9 months.

43 The nuclear cataract caused by alphaA-Y118D mutation was ass

44 Association between nuclear cataract change and micronutrients was investiga

45 verexpressing the PD of Pax-6 have posterior nuclear cataracts composed of cell debris, whereas the r

46 ven in such a clearly age-related disease as nuclear cataract, explaining almost 50 percent of the va

47 sequently combined in one summary measure of nuclear cataract for each woman.

48 xperiments revealed a similar progression to nuclear cataract formation as seen in vivo.

49 ge-related event associated with age-related nuclear cataract formation in Cx46KO mice, and further s

50 otocol (cortical cataract: opacity >or=4/16; nuclear cataract grade >or=2) were collected.

51 lear cataract and the sibling correlation of nuclear cataract grade, after adjusting for covariates,

52 molecular mechanisms that lead to a dominant nuclear cataract in a mouse harboring the Y118D mutation

53 additional insights into the pathogenesis of nuclear cataract in Asians.

54 for incident cataract, of whom 57 developed nuclear cataract in at least one eye.

55 o3 (nuclear opacity 3) is a novel congenital nuclear cataract in mice.

56 nfirmed two genome-wide significant loci for nuclear cataract in the combined meta-analysis of four c

57 A total of 210 persons developed incident nuclear cataract in the interval from 1998-2000 to 2003-

58 The amount of nuclear cataract in the right and left eyes was determin

59 necessary for the formation of age-dependent nuclear cataracts in alpha3Cx46-/- mice.

60 Supra-nuclear cataracts in DS have been proposed as indicative

61 RYGC5bpd mutant gammaC-crystallin results in nuclear cataracts in which lens fiber cells begin to sho

62 ression to cataract surgery at 5 years were: nuclear cataract increase of 1.0 unit or more compared w

63 ns capsule, respectively, as the severity of nuclear cataract increases.

64 However, the dominant nuclear cataract is associated with a significant decrea

65 However, the association between myopia and nuclear cataract is explained by lens refraction rather

66 d that in 129alpha3Cx46-/- mice, age-related nuclear cataract is formed.

67 n aggregates during the development of human nuclear cataract is not well understood.

68 A major component of human nuclear cataracts is water-insoluble, high molecular wei

69 the 1,354 persons eligible, 246 developed a nuclear cataract (level 4 or 5 opacity) in at least one

70 noids were not significantly associated with nuclear cataract, marginal inverse associations with lut

71 gs were compatible with the possibility that nuclear cataract may be linked inversely to vitamin E st

72 that the MLBs observed in human age-related nuclear cataracts may be major sources of forward light

73 omography to directly examine an age-related nuclear cataract model in Cx46 knockout (Cx46KO) mice.

74 -3.30) among individuals with a sibling with nuclear cataract (nuclear grade > or = 3.0).

75 trolled for, myopia was related to prevalent nuclear cataract (odds ratio [OR], 1.67; 95% confidence

76 intake had the following associations: mild nuclear cataract: odds ratio (OR), 0.78; 95% confidence

77 el indicated a magnitude of heritability for nuclear cataract of 35.6% (95% CI: 21.0%-50.3%) after ad

78 new locus for autosomal recessive congenital nuclear cataracts on chromosome 19q13 in a consanguineou

79 However, the odds ratio for nuclear cataract (opalescence) among subjects whose birt

80 ecruited two Chinese families with bilateral nuclear cataract or zonular pulverulent phenotype.

81 aract: OR, 0.78; 95% CI, 0.63-0.96; moderate nuclear cataract: OR, 0.62; 95% CI, 0.43-0.88; and mild

82 onfidence interval (CI), 0.63-0.97; moderate nuclear cataract: OR, 0.62; 95% CI, 0.43-0.90; and mild

83 For B12, the results were: mild nuclear cataract: OR, 0.78; 95% CI, 0.63-0.96; moderate

84 ained 35% of the variation in progression of nuclear cataract over a 10-year period.

85 baseline and the 10-year incidence of either nuclear cataract (P < .0001) or cataract surgery (P < .0

86 prevalence of cortical cataract (P=.02) and nuclear cataract (P < .0001) than eyes without PXS.

87 acy (P = 0.02), pseudophakia (P = 0.04), and nuclear cataract (P = 0.05).

88 46), whereas the association between PXS and nuclear cataract persisted after adjustment for the abov

89 gainst both nuclear cataract at baseline and nuclear cataract progression (beta = -0.0002, P = 0.01 a

90 ing model estimated that the heritability of nuclear cataract progression was 35% (95% confidence int

91 y to have AMD and DR but more likely to have nuclear cataract, PSC, and POAG.

92 TG MLR21 embryos, result in severe bilateral nuclear cataracts readily observable in neonates under n

93 cause recessive whole cataracts and dominant nuclear cataracts, respectively.

94 ince quitting vs. current smoking: primarily nuclear cataract, RR = 0.82, 95% CI: 0.68, 0.97; primari

95 The overall heritability in the combined nuclear-cataract score (the proportion of the variance e

96 Quantitative genetic modeling of each of the nuclear-cataract scores invariably resulted in a best-fi

97 oss-sectional association between myopia and nuclear cataract seen in other population-based studies,

98 al axis of human eye lenses with age-related nuclear cataract showed increasing concentration of fluo

99 fed the galactose diet for 5 to 9 days, and nuclear cataracts subsequently developed in these lenses

100 zation of Sep15 KO mice revealed a prominent nuclear cataract that developed at an early age.

101 gous for the disrupted alpha3 gene developed nuclear cataracts that were associated with the proteoly

102 s (e.g., asteroid hyalosis), and lens (e.g., nuclear cataracts) that were not predefined by human lab

103 appears to be associated with lower risk of nuclear cataract, the most common type of age-related ca

104 n and vitamins E and C on the development of nuclear cataracts, the evidence in the present study pro

105 of genes and environment in the causation of nuclear cataracts, the most common form of age-related c

106 Five-year incidence of nuclear cataract was 12.2% in statin users compared with

107 Nuclear cataract was measured using a quantitative measu

108 cal significance of even the highest scoring nuclear cataract was negligible.

109 ovariates, the probability of development of nuclear cataract was significantly increased (odds ratio

110 of antioxidant nutrients to the incidence of nuclear cataracts was investigated in a cohort of adults

111 tocopherols to the incidence of age-related nuclear cataract were investigated in a random sample of

112 The in vitro AGEs and classified nuclear cataracts were analyzed by SF and immunochemical

113 In the overall group, nuclear cataracts were not significantly related to inta

114 gammaB(I4F/+) mutant lenses displayed severe nuclear cataracts, whereas the lens cortex remained unaf

115 th the severity of posterior subcapsular and nuclear cataracts, which was the only feature associated

116 develop microphthalmia with small lenses and nuclear cataracts, while the alpha8 heterozygous (+/-) m

117 The higher risk of nuclear cataract with increased birth weight was contrar

118 It soon progresses to a large white nuclear cataract with mild cortical changes.

119 ated the hypothesized inverse association of nuclear cataract with serum carotenoids.

120 on of Gja3 (alpha3 connexin), mice developed nuclear cataracts with a normal sized lens.

121 and were deemed to be at risk of developing nuclear cataract within 5 years.