ライフサイエンスコーパス: nucleation

1 he gamma-tubulin ring complex in microtubule nucleation.

2 through a process known as heterogeneous ice nucleation.

3 nsient oligomers generated through secondary nucleation.

4 many orders of magnitude faster than primary nucleation.

5 dendritic microtubule dynamics by inhibiting nucleation.

6 is followed by features exhibiting two-step nucleation.

7 tin-based motility induced by Arp2/3 complex nucleation.

8 pathway that regulates dendritic microtubule nucleation.

9 are disfavored at the earliest stages of FUS nucleation.

10 spatio-temporal regulation of actin filament nucleation.

11 nt of EB1 to the centrosome and regulates MT nucleation.

12 mDia1 complex that greatly enhances filament nucleation.

13 centration below which growth dominates over nucleation.

14 hydrophobic patches play a role in secondary nucleation.

15 than those in bulk samples, which delays PSB nucleation.

16 fore conclusively reconstitutes branching MT nucleation.

17 iency of TPX2-mediated branching microtubule nucleation.

18 mimic a filamentous actin dimer and template nucleation.

19 n important role in the process of microvoid nucleation.

20 challenging due to the difficulty in initial nucleation.

21 al cellular phenomenon termed 'branching' MT nucleation.

22 be rescued by disrupting APC-mediated actin nucleation.

23 ing the PVDF chains and promoting beta-phase nucleation.

24 otocol to promote ring closure and secondary nucleation, a maximum catenation number of 22 was confir

25 These particles possess ice-nucleation activities high enough to be relevant to mixe

26 The net charge correlates with the ice nucleation activity of the INP aggregates, which is mini

27 omal degradation through its endosomal actin nucleation activity.

28 al water molecules and the corresponding ice nucleation activity.

29 oduce a "seed" strand to control the crucial nucleation and assembly pathway in DNA brick assembly.

30 modification of the molecular actin filament nucleation and assembly rates.

31 toward the base of the pit, increasing actin nucleation and bending for increased force production.

32 tions ultimately disfavor growth compared to nucleation and can suppress yield completely.

33 th different shapes and sizes as affected by nucleation and crystal growth rates.

34 in the matrix can lead to coupled microvoid nucleation and early fiber breakage, and that small frag

35 g the kinetics and thermodynamics of amyloid nucleation and elongation of amyloidogenic proteins/pept

36 ve monomer concentration dependencies of the nucleation and elongation processes.

37 whereas PSMbeta2 aggregates through primary nucleation and elongation.

38 lexibility of DNA positively correlates with nucleation and extension of the RAD51 nucleoprotein fila

39 isulfide bonds and then proceeds via primary nucleation and fibril elongation processes.

40 in are important for delaying amyloid fibril nucleation and for disaggregating mature apolipoprotein

41 cidate the key factors that influence the Na nucleation and growth behaviors based on the existing th

42 All emulsifiers accelerated cocoa butter nucleation and growth from the melt, with PGPR showing t

43 s using COF-5 as an example, which show that nucleation and growth have second-order and first-order

44 s transition is unique in that it involves a nucleation and growth mechanism that converts to a faste

45 insufficient understanding of the governing nucleation and growth mechanisms in p-MOF systems.

46 impurity phases is hard to suppress, and the nucleation and growth mechanisms thereon have not been s

47 y amides may have important implications for nucleation and growth of atmospheric secondary organic a

48 or bilayer s-TMDs, we precisely control the nucleation and growth of diverse m-TMDs with designable

49 The nucleation and growth of macroscopic single crystals is

50 Nucleation and growth of new particles were observed in

51 of VC, whereby (OEG(2))(2)-IP4 disrupts the nucleation and growth of pathological calcification.

52 anocrystalline grain serve to accelerate the nucleation and growth of the BCC phase during irradiatio

53 cles plays a strong role both in guiding the nucleation and growth of the catalytically active ultras

54 tic transition temperatures and dictates the nucleation and growth of the magnetic phases.

55 hese three synergistic factors influence the nucleation and growth process both thermodynamically and

56 This mechanistic understanding of the nucleation and growth processes will inform the rational

57 e, we present a quantitative analysis of the nucleation and growth rates of 2D COFs via kinetic Monte

58 rimentally by systematic measurements of COF nucleation and growth rates performed via in situ X-ray

59 re attributed to the significantly different nucleation and growth rates, with a difference in the gr

60 g of the influence of confinement on crystal nucleation and growth will not only provide superior ins

61 Fundamental aspects, including perovskite nucleation and growth, heterojunction electron-hole tran

62 that the ant epicuticle catalyzes biomineral nucleation and growth.

63 that are otherwise not accessible by direct nucleation and growth.

64 Hence, the Na nucleation and initial stage of growth are critically im

65 rnary complex at filament barbed ends, or by nucleation and interaction at filament pointed ends.

66 nding highlights the generality of secondary nucleation and its independence of the detailed molecula

67 nt roles in promoting Arp2/3-dependent actin nucleation and lamellipodia formation, but distinct role

68 How microtubule nucleation and polarity are regulated within neurons rem

69 ons on the kinetic pathway of actin filament nucleation and polymerization and possibilities for futu

70 may conspire with each other to enhance the nucleation and propagation of different diseases, thus s

71 We also expect nitric acid and ammonia nucleation and rapid growth to be important in the relat

72 n interface type and spacing, damage (voids) nucleation and spall failure is observed to occur not on

73 ibrium self-assembly of domains, and bridges nucleation and spinodal decomposition via the sequential

74 nd their adaptors during early stages of CCP nucleation and stabilization and highlight the importanc

75 n that is the fundamental step in plectoneme nucleation and supercoil dynamics, which are critical fo

76 different surface conditions showed that the nucleation and the growth processes of condensate water

77 ntitative understanding of heterogeneous ice nucleation and the in silico design of materials to cont

78 Ice nucleation and the resulting cloud glaciation are signif

79 -liquid interfaces as favorable sites of ice nucleation and uses preconditioning with cryoprotective

80 eating before crystallization leads to fewer nucleations and faster removal of the precursors, improv

81 other phenomena, such as electrodeposition, nucleation, and membrane deformation.

82 wever, details of the mechanism that impedes nucleation are broadly considered irrelevant.

83 us, their modes of action during microtubule nucleation are distinct.

84 epresent direct identification of earthquake nucleation as a transient consequence of ongoing, locali

85 en mutants retain the dominance of secondary nucleation as the main mechanism of fibril proliferation

86 syringae by combining a high-throughput ice nucleation assay with surface-specific sum-frequency gen

87 uorescence (TIRF) microscopy-based real-time nucleation assay.

88 matical modeling, enabled us to quantify the nucleation, assembly, and disassembly kinetics of Tpm1.8

89 d that Ror may act by regulating microtubule nucleation at baseline and during dendrite regeneration.

90 enhancer-promoter contact, either by cluster nucleation at binding sites or by bulk spontaneous forma

91 homolog (WASH) complex that activates actin nucleation at endosomes.

92 gmin enable gamma-TuRC-dependent microtubule nucleation at preferred branching angles of less than 90

93 able in situ imaging of the initial steps of nucleation at the atomic scale.

94 ed to be on-path transients that precede the nucleation barrier.

95 e(2) crystals into rhombus due to the higher nucleation barriers for stable attachment on the (1,1) a

96 we develop a poroelastic model of earthquake nucleation based on rate-and-state friction in the manne

97 l understanding of the surface chemistry and nucleation behavior of iron(III) (hydr)oxides in subsurf

98 is discovery provides deep insights into the nucleation behavior of octahedra-array-based perovskite

99 ropose a model to relate electrochemical and nucleation behavior.

100 ght into the mechanism of gammaTuRC-mediated nucleation by determining the structure of human gammaTu

101 ssible regulatory mechanisms for microtubule nucleation by gammaTuRC closure.

102 Loss of barbed-end binding increases nucleation by Spire and synergy with Cappuccino in bulk

103 ins treadmilling, and also explains assembly nucleation by the same mechanisms.

104 esults are consistent with a model that Dmc1 nucleation can be facilitated by a structural component

105 f physical descriptors for heterogeneous ice nucleation can be identified.

106 In addition, ScDmc1 nucleation can be stimulated by short ScRad51 patches, b

107 Heterogeneous ice nucleation caused by ice-nucleating particles (INPs) ena

108 eat location shows that A-repeat serves as a nucleation center for multiple Xist-associated proteins

109 solvent, suggests that in this system a Pre-Nucleation Cluster (PNC) pathway is followed by features

110 r, the conformational pathway leading to the nucleation-competent state is unclear due to lack of hig

111 nteractions renders capturing this transient nucleation complex using traditional structural biology

112 e cytoplasmic receptor for the gamma-tubulin nucleation complex, as the most upstream determinant lin

113 ts, and two functional readouts of dendritic nucleation confirmed a role for Wnt signaling proteins.

114 In this work, we develop a nucleation-controlled solution method to grow large size

115 letion of Arl4D resulted in a centrosomal MT nucleation defect.

116 It is furthermore delineated how low nucleation density and large growth rates can be inferre

117 function as a capping layer that reduces the nucleation density and promotes lateral growth.

118 data show that the GNNQQNY sequence follows nucleation-dependent aggregation kinetics with a critica

119 sion in the 5'-to-3' polarity, while ScRad51 nucleation depends strongly on ssDNA lengths.

120 l Ostwald ripening, which prevents secondary nucleation despite high precursor concentrations.

121 ent of protein crystallization by a discrete nucleation domain may enable engineering of kinetically

122 rs of magnitude faster due to the N-terminal nucleation domain.

123 crystalline intermediate wherein N-terminal nucleation domains exhibit motional dynamics with respec

124 e pointed ends are retained, as expected for nucleation-driven synergy.

125 Replacing ordinary nucleation, each impurity opens up a proton ring generat

126 ion, while XMAP215 drastically increases the nucleation efficiency by strengthening the longitudinal

127 to a structural asymmetry explaining the low nucleation efficiency of purified human gammaTuRC.

128 ntrosymmetric columnar polymer, exhibiting a nucleation-elongation polymerization mechanism.

129 energy suppresses dendrites by enhancing the nucleation energy and suppressing the Li penetration int

130 modulate downstream elongation or secondary nucleation events.

131 independently of the widespread microtubule nucleation factor gamma-Tubulin.

132 Aldrich syndrome protein(N-Wasp) is an actin nucleation factor that promotes polymerization of branch

133 uding elevated mononuclear invasion, central nucleation, fibrosis and declined forelimb grip strength

134 l hallmarks of fibre size variation, central nucleation, fibrosis and necrosis/regeneration/inflammat

135 have been applied to effectively regulate Na nucleation for dendrite-free Na deposition.

136 three main processes prior to heterogeneous nucleation: formation of crystal nuclei directly from an

137 air/liquid interface followed by subsequent nucleations forming slightly less oriented 2D perovskite

138 s: with ARL2 and TBCD to support microtubule nucleation from centrosomes and with ARF6 in cytokinesis

139 n requires assembly of 8 alphabeta-tubulins, nucleation from gamma-TuRC occurs efficiently with a coo

140 growth of zeolite A where we show that layer nucleation from surface defects is the most common pathw

141 that EB1 binds APC-B and inhibits its actin nucleation function by blocking actin monomer recruitmen

142 The nucleation, growth, and transformation of anodized amorp

143 block copolymerization process to unravel a nucleation-growth mechanism, similar to that of chain co

144 Our data suggested that a nucleation-growth model is responsible for the adsorptio

145 lar hexosomes do not form via a conventional nucleation-growth self-assembly pathway, but rather via

146 composition of the metal salt precursors and nucleation/growth of multimetallic particles.

147 We investigate two key scenarios to delay nucleation: (i) by introducing a slow activation step fo

148 amics, it stimulates gamma-TuRC-dependent MT nucleation in a cell cycle-dependent manner.

149 mutations that affect ciliary structure and nucleation in PCD(4), but the regulation of mucociliary

150 PX2) is an effector of branching microtubule nucleation in spindles and functions with the substrate

151 ate with tubulin, which mediates microtubule nucleation in vitro and in isolated cytosol.

152 opposite side of gammaTuRC is in an "open," nucleation-incompetent conformation, leading to a struct

153 This suggests that ice-nucleation-induced wounding of the wheat leaf provides a

154 lerates the addition of subunits to existing nucleation intermediates formed either spontaneously or

155 Thus, increased nucleation is a critical element of synergy both in vitr

156 However, it is becoming apparent that nucleation is often more complicated than this simple pi

157 Template-directed nucleation is replicated in a bulk alloy as well as unde

158 Microtubule nucleation is spatiotemporally regulated in cells by sev

159 tions suggest that the essential step in the nucleation is the initial merger of lipid headgroups at

160 The role of XMAP215 in nucleation is under debate, specifically whether it acts

161 ranching, previously attributed to secondary nucleation, is reduced in absence of htt(NT).

162 The model could match nucleation kinetics of several flavors of FtsZ using the

163 assically defined nucleator that reduces the nucleation lag seen in bulk tubulin assembly.

164 ctures that promote acentrosomal microtubule nucleation, less is known about the structures that medi

165 including dsh and Axin, localize microtubule nucleation machinery in dendrites.

166 tudy gives a quantitative description of the nucleation mechanism and energetics of small metastable

167 h-resolution direct evidence of the twinning nucleation mechanism in HCP crystals.

168 scopy, we directly show a dual-step twinning nucleation mechanism in HCP rhenium nanocrystals.

169 on an explicit understanding on the twinning nucleation mechanism in hexagonal close-packed (HCP) cry

170 ucleus formation occurred through a two-step nucleation mechanism.

171 action coordinates and also to determine the nucleation mechanism.

172 particles was bimodal for all the fuels, the nucleation mode highly dominating the soot mode.

173 ng proteins (INPs) promote heterogeneous ice nucleation more efficiently than any other material.

174 ence that self-replication through secondary nucleation occurs along the sides of fibrils, which beco

175 rom homogeneous to heterogeneous dislocation nucleation occurs as the interface spacing is decreased

176 Nucleation of a growing tropomyosin domain proceeds with

177 single molecule assay to directly visualize nucleation of a MT from purified Xenopus laevis gamma-Tu

178 Transcription factor-dependent nucleation of a myosin motor propels the gene locus thro

179 mbrane curvature of ER tubules catalyzes the nucleation of a neutral lipid lens, an early step in LD

180 omote the development of membrane proximity, nucleation of a stalk, and triggered expansion of the fu

181 onal theory calculations, we report that the nucleation of a thermodynamically stable, atomically thi

182 on in the plane of the synapse through focal nucleation of actin via Wiskott-Aldrich syndrome protein

183 g, we find that the peptide inhibits primary nucleation of alphaS, but does not modulate downstream e

184 The nucleation of Alzheimer-associated Abeta peptide monomer

185 ation and modelling helped to understand the nucleation of anatase and rutile and the reorganization

186 nscription factors, and in the formation and nucleation of autophagic vesicles by cysteine modificati

187 he centriole in animals and functions in the nucleation of axonemal microtubules in the flagellum.

188 he explanations offered for the preferential nucleation of BCC over FCC in metallic alloys.

189 The method involves suppressing the nucleation of both layered and 3D perovskites inside the

190 n-mediated endocytosis (CME) begins with the nucleation of clathrin assembly on the plasma membrane,

191 on of step edges, which facilitates both the nucleation of crystal layers and step propagation throug

192 biochemistry, ranging from metabolism to the nucleation of cytoskeletal filaments.

193 By stopping barbed end growth, CP favors nucleation of daughter filaments at the functionalized s

194 hat Gag binding to Psi specifically promotes nucleation of Gag-Gag interactions at the early stages o

195 hts into the thermodynamic mechanism for the nucleation of intermixing-induced buffer layers that can

196 ofilms provided an organic framework for the nucleation of iron oxide minerals.

197 atalytic reaction network coupled with burst nucleation of nanoparticles above a critical supersatura

198 involves disassembly of old microtubules and nucleation of new microtubules.

199 assembly is that, for high production yield, nucleation of structures must be significantly slower th

200 genomic loci lower the energetic barrier for nucleation of TAF15 condensates, which in turn further r

201 species during the aggregation and secondary nucleation of the Abeta42 peptide.

202 Above 7 GPa, concomitantly to the nucleation of the amorphous phase, we observe a peculiar

203 egree of catenation stems from the secondary nucleation of the precursor molecules around the toroids

204 We find that nucleation of the predominant {1 0 -1 2} twinning is ini

205 tion theory calculations, we investigate the nucleation of the strengthening phase theta' onto a temp

206 ), is used to study the energy landscapes of nucleation of the two different fibrils derived from pat

207 has been proposed to stimulate the efficient nucleation of viral assembly.

208 However, these pre-nucleation oligomeric aggregates are transient and diffi

209 ng fundamental processes such as precipitate nucleation on bacteria, microbe-mineral interactions, an

210 on (E(a)) energies, of iron(III) (hydr)oxide nucleation on earth-abundant mineral surfaces have not b

211 ed alpha' and E(a) for iron(III) (hydr)oxide nucleation on quartz mineral surfaces by employing a flo

212 mains rationalizes efficient S-layer crystal nucleation on the curved cellular surface.

213 roliferation of amyloid fibrils by secondary nucleation on the fibril surface.

214 re are at least two independent processes in nucleation, one promoted by gamma-tubulin and one promot

215 This template-directed solid-state nucleation pathway is enabled by the large influx of sur

216 k provides a blueprint for other microtubule nucleation pathways and helps explain how microtubules a

217 he factors that constitute these microtubule nucleation pathways and their mode of action still need

218 o the growing body of evidence that suggests nucleation pathways are likely an amalgamation of multip

219 We identify two physically distinct nucleation pathways-protein-rich and lipid-rich-and quan

220 that DNAJB6 especially inhibits the primary nucleation pathways.

221 Our results suggest that the nucleation phase of Cascadia slow slip events may last f

222 embly through Arp2/3 complex-dependent actin nucleation, plays a critical role in CNS myelination, an

223 may serve as interaction, condensation, and nucleation points.

224 This nucleation preference is also conserved for mammalian RA

225 Nucleation proceeded normally at the RNA interference (R

226 This secondary nucleation process can be many orders of magnitude faste

227 n-transport molecular matrix, which controls nucleation process of perovskites, leading to PeLEDs wit

228 and that the specific implementation of the nucleation process plays a significant role in determini

229 y profile associated with this heterogeneous nucleation process, in which the surface itself particip

230 stals by temporally resolving the growth and nucleation processes.

231 In vitro, the nucleation-promoting factor SPIN90 promotes formation of

232 Here we investigate how nucleation-promoting factors mediate interactions betwee

233 Nucleation-promoting proteins tightly regulate actin pol

234 We purified human gammaTuRC and measured its nucleation properties in a total internal reflection flu

235 g proteins regulate localization of the core nucleation protein gammaTubulin (gammaTub).

236 th this hypothesis, localization of the core nucleation protein gammaTubulin was reduced in Ror RNAi

237 bolishing Arl4D-EB1 interaction decreased MT nucleation rate and diminished the centrosomal recruitme

238 lular junctions mediating an increase in aSF nucleation rate and lifetime in larger cells.

239 The lower nucleation rate of ScDmc1 results from its lower single-

240 the previously observed decrease in primary nucleation rate, strong binding of Abeta oligomers to DN

241 of protein-membrane interactions have on the nucleation rates of amyloid fibrils.

242 e in situ detection of iron(III) (hydr)oxide nucleation rates under different supersaturations (sigma

243 account for the Rayleigh-Taylor instability, nucleation rates, and superheat limits.

244 sible even in systems dominated by secondary nucleation rather than fragmentation.

245 d) phase, the PHD proteins are lost from the nucleation region and silencing is likely maintained by

246 A combination of noncoding SNPs in the nucleation region mediates instability in this long-term

247 s far, many aspects of the mechanisms of CaP nucleation remain unclear due to the absence of experime

248 Whereas spontaneous nucleation requires assembly of 8 alphabeta-tubulins, nu

249 proach may lead to a profound change in both nucleation research and industrial practice well beyond

250 anched oligomerization pathway that precedes nucleation, resulting in an increase in the populations

251 atomic-scale mechanisms associated with the nucleation, rotation and amorphization-crystallization o

252 e conformationally defined size of the Sup35 nucleation seed and suggest that amyloid is actively cle

253 , our observations establish the size of the nucleation seed as a previously unappreciated characteri

254 ating the formation of an assembly-competent nucleation seed, but we find an unanticipated role for t

255 show through a machine learning analysis of nucleation simulations on a database of diverse model su

256 roth vesicles and prompt reactivation of the nucleation site favoured the packing of vesicles and the

257 h an attenuation of H3K27me3 at the internal nucleation site in FLC, and reduction in H3K27me3 levels

258 led Na deposition behavior in the absence of nucleation site regulation.

259 on spreading around an artificially induced "nucleation site." We show that our model recreates both

260 leased smaller Au NPs as numerous cavitation nucleation sites and Mn(2+) for chemodynamic therapy (CD

261 d stress is approached, multiple dislocation nucleation sites appear simultaneously from the high-str

262 the new SPB promotes the correct balance of nucleation sites between the nuclear and cytoplasmic fac

263 Nucleation sites concentrate at dendrite branch points,

264 key role in the magnetic state by acting as nucleation sites for magnetization reversal.

265 on of the stacking-fault networks to provide nucleation sites for the hcp phase transformation.

266 at the defective T-graphite provide numerous nucleation sites for the nanoparticles to form.

267 lysis to explore the asymmetric landscape of nucleation sites inherently built into the spindle pathw

268 By selectively patterning nucleation sites on monolayer or bilayer s-TMDs, we prec

269 ns are housed on early endosomes and recruit nucleation sites to branch points.

270 er, we show these active colloids can act as nucleation sites, and switch rapidly the interactions be

271 the frequency of microtubule emergence from nucleation sites.

272 ases, and depends on the number of stable MT nucleation sites.

273 ompeting for monomers and blocking secondary nucleation sites.

274 lethality caused by partial defects in actin nucleation/stability caused, for example, through compro

275 ones because of the kinetically much reduced nucleation step.

276 ar mechanisms through which this accelerated nucleation takes place are not yet understood.

277 and predict the exact location of microvoid nucleation that occurs during damage initiation within t

278 ce allows us to study fundamental aspects of nucleation that remain elusive for classic, fast earthqu

279 m medicine to biotechnology to heterogeneous nucleation, the question about its dominant forces and c

280 s been directed toward understanding amyloid nucleation, the understanding of their optical propertie

281 mic-scale imaging, simulations and classical nucleation theory calculations, we investigate the nucle

282 examined by combining elements of classical nucleation theory to the large-scale hydrodynamics on th

283 By quantitative analyses based on classical nucleation theory, alpha' was obtained to be 34.6 mJ/m(2

284 Using fluid dynamical considerations and nucleation thermodynamics, we provide mechanistic unders

285 our results indicate that Arl4D modulates MT nucleation through regulation of the EB1-p150 associatio

286 ures the spatio-temporal regulation of actin nucleation to stimulate robust and localized actin filam

287 phenomenon has been elusive due to rapid ice nucleation under deeply supercooled conditions.

288 roach to grain refinement has been to reduce nucleation undercooling by the addition of potent nuclea

289 efinement can be achieved through increasing nucleation undercooling by using impotent nucleant parti

290 tunability in two areas: favorability of NP nucleation versus growth and phase formation.

291 xperiments involving spatially biasing actin nucleation via optogenetics and disruption of mitochondr

292 size ~7 monomers and that the efficiency of nucleation were found to be inversely related to the rea

293 D COF single crystals, growth dominates over nucleation when monomers are added slowly, so as to limi

294 a1, PSMalpha3 and PSMbeta1 display secondary nucleation whereas PSMbeta2 aggregates through primary n

295 hemically reconstitute branching microtubule nucleation, which is critical for chromosome segregation

296 iciency and spatially coordinate microtubule nucleation, which may facilitate rapid and accurate spin

297 ion domain of CDK5RAP2 h gamma-TuRC-mediated nucleation, while XMAP215 drastically increases the nucl

298 We studied actin filament polymerization and nucleation with molecular dynamics simulations and a pre

299 tic model is presented to relate dislocation nucleation with plasticity in silicon.

300 y, indicating a templating role of secondary nucleation with structural conversion at the fibril surf