ライフサイエンスコーパス: nucleic acid

1 tudy yielded positive results for SARS-CoV-2 nucleic acid.

2 teins to complementary sequences in invading nucleic acid.

3 scopes, but has been limited to proteins and nucleic acids.

4 tant tool to probe conformational changes in nucleic acids.

5 ptive immunity to target and degrade foreign nucleic acids.

6 onjugates of antibodies, growth factors, and nucleic acids.

7 olayer graphene channel for the detection of nucleic acids.

8 ant type I IFNs (IFN-I) in response to viral nucleic acids.

9 not require conjugation of organic dyes with nucleic acids.

10 gests that ZBP1 may recognize nuclear Z-form nucleic acids.

11 viruses by degradation of specific invading nucleic acids.

12 gen implicated in the damage of proteins and nucleic acids.

13 luding the polyanions glycosaminoglycans and nucleic acids.

14 em that protects prokaryotes against foreign nucleic acids.

15 analyzing 3D structures of both proteins and nucleic acids.

16 s and interact with lipids and intracellular nucleic acids.

17 detection of pathogen-specific sequences of nucleic acids.

18 n the detected level of human and SARS-CoV-2 nucleic acids.

19 ly using plasma-derived, cell-free microbial nucleic acids.

20 ir sequence homology with abundant wild-type nucleic acids.

21 rescence spectra of aromatic amino acids and nucleic acids (AAA + NA), tryptophan residues, nicotinam

22 These advances, together with nucleic acids' ability to respond to various stimuli (en

23 NA polymerase complex, subsequently reducing nucleic acid affinity.

24 s part of the adaptive response to exogenous nucleic acid-alkylating agents.

25 n-derived molecules (eg, lipopolysaccharide, nucleic acids) also translocate from the gastrointestina

26 luded an increase in the relative content of nucleic acids, alteration in the alpha-helical/beta-shee

27 technique, responsible for the generation of nucleic acid amplicons as RCA products (RCPs).

28 Combining loop-mediated isothermal nucleic acid amplification (LAMP) and bioluminescent ass

29 Gram-Positive (BCID-GP) Panel is a multiplex nucleic acid amplification assay based on competitive DN

30 Nucleic acid amplification for the detection of severe a

31 ion (C2CA) is a specific and precise cascade nucleic acid amplification method consisting of more tha

32 ollection) and a positive stool C. difficile nucleic acid amplification test were enrolled.

33 , we enrolled men who have sex with men with nucleic acid amplification test-diagnosed pharyngeal gon

34 94.7%, respectively, after 48 h compared to nucleic acid amplification testing (NAAT).

35 Digital nucleic acid amplification tests (digital NAATs) have em

36 Nucleic acid amplification tests (NAATs) are the primary

37 The development and maturation of automated nucleic acid amplification tests (NAATs) has greatly imp

38 Nucleic acid amplification tests (NAATs) such as real-ti

39 FA) testing, immunohistochemistry (IHC), and nucleic acid amplification tests (NAATs).

40 Highly sensitive and specific nucleic acid amplification tests have become the diagnos

41 The structure provides a model for nucleic acid/amyloid co-assembly as well as insight into

42 e hexopyranose chemical modification Altriol Nucleic Acid (ANA) within small interfering RNA (siRNA)

43 trates SPME as a sample preparation tool for nucleic acid analysis in plasma.

44 thermal biosensing strategy for quantitative nucleic acid analysis on microfluidics using a thermomet

45 on partitions, a key requirement for digital nucleic acid analysis.

46 Ts for the orphan XNA chemistries D-altritol nucleic acid and 2'-methoxyethyl RNA, for which previous

47 ments due to their ability to recognize both nucleic acid and non-nucleic acid targets, ease of synth

48 pically involves recombination between donor nucleic acids and acceptor genomic sequences subjected t

49 nt technologies have been limited to natural nucleic acids and are often incompatible with polymerase

50 overview of covalent labeling approaches for nucleic acids and highlight notable developments, in par

51 the gut microbiome, other resources such as nucleic acids and nucleosides are less studied.

52 ting in production of autoantibodies against nucleic acids and other cellular Ags.

53 etic mutation, and binding interactions with nucleic acids and small molecules.

54 fficient RTs for 2'-O-methyl RNA and hexitol nucleic acids and the discovery of RTs for the orphan XN

55 low concentrations of clinically significant nucleic acids and their sequence homology with abundant

56 metazoans and an essential cofactor for ATP, nucleic acids, and countless metabolic enzymes.

57 rtain biological properties of linear/cyclic nucleic acids, and enable antibody-level targeting using

58 o the interactions of domains with peptides, nucleic acids, and ligands.

59 cells to control the transport of proteins, nucleic acids, and other macromolecules.

60 nfirmed the presence of lipopolysaccharides, nucleic acids, and protein in OMVs; however, these assay

61 e COVID-19 via rapid testing, mainly through nucleic acid- and antibody- testing.

62 to analyze the cross-over) and the protein-, nucleic acid- and small ligand-binding proteins (to stud

63 by intracisternal administration of a locked nucleic acid antisense oligonucleotide to young-adult as

64 drate ligands, small molecules, peptides and nucleic acid aptamers and we portray work performed with

65 multivalent nucleic acid nanostructures, and nucleic acid aptamers, which, respectively, provide the

66 thermal responsiveness to theoretically any nucleic acid architecture, addressing a significant need

67 Recently, researchers are increasingly using nucleic acid architectures for multivalent ligand presen

68 Nucleic acids are a promising type of therapeutic for th

69 Pathogen-derived nucleic acids are crucial signals for innate immunity.

70 Indeed, unmodified nucleic acids are enzymatically unstable, too hydrophili

71 Nucleic acids are important biological cues that encode

72 Short single-stranded nucleic acids as found in a variety of bodily fluids hav

73 The present perspective introduces nucleic acids as functional modules to construct constit

74 M is synthesized on the cell surface through nucleic acid assembly and hybridization.

75 elivery system that can release a functional nucleic acid at the intracellular destination site is an

76 owerful single-cell technique that harnesses nucleic acid base pairing to detect the abundance and po

77 A typical nucleic acid-based diagnostic test consists of three maj

78 Nucleic acid-based materials enable sub-nanometer precis

79 Nucleic acid-based molecular diagnosis reveals valuable

80 RISPR-Cas technology has opened a new era of nucleic acid-based molecular diagnostics.

81 Nucleic acid-based pattern recognition receptor agonists

82 se polymerase chain reaction tests and rapid nucleic acid-based tests offer good performance in most

83 4)/GNF/GCE was utilized for the detection of nucleic acid bases with a well resolved oxidation peak f

84 ing was for the HOS determination of protein/nucleic acid binding, the concept was later adapted to M

85 function predictions that cover protein and nucleic acids binding, linkers, and moonlighting regions

86 e domain of HP1gamma that confer protein and nucleic acid-binding ability are sufficient because they

87 The structure places the nucleic acid-binding ATPase domains of the helicase dire

88 trated by genetic perturbation that cellular nucleic acid-binding protein (CNBP) and La-related prote

89 protein related to the human single-stranded nucleic acid-binding protein Pur-alpha, as a component o

90 Here, we find that PRC2 interacts with the nucleic acid-binding protein Ybx1.

91 y leading from a polypeptide to a ubiquitous nucleic acid-binding protein.

92 psulation of cellular proteins, particularly nucleic-acid-binding proteins.

93 biosensors that can detect both protein and nucleic acid biomarkers for multiparametric diagnostic a

94 However, current CRISPR-Cas-based nucleic acid biosensing has a lack of the quantitative d

95 lyzed by incorporating a gold nanorod-locked nucleic acid biosensor.

96 Recognition of self-nucleic acids by innate immune receptors can lead to the

97 and suggest that the recognition of foreign nucleic acids by prokaryotic defence systems involves co

98 idence that the sensing of endogenous Z-form nucleic acids by ZBP1 triggers RIPK3-dependent necroptos

99 Previous studies have shown that nucleic acids can nucleate protein aggregation in diseas

100 ra- and intra-cellular barriers, protect the nucleic acid cargo from degradation with stability over

101 riers (<100 nm) that efficiently encapsulate nucleic acid cargo, exhibit sustained release of payload

102 ayed Reactions for Multiplexed Evaluation of Nucleic acids (CARMEN), a platform for scalable, multipl

103 progress in understanding the strategies of nucleic acids catalysts has been made by providing thoro

104 r imaging purposes and other applications in nucleic acid chemistry and biotechnology.

105 c complementarity and define a novel amyloid/nucleic acid co-assembly.

106 eractions at early stages of polypeptide and nucleic acid co-existence.

107 of organizing cytosol in which proteins and nucleic acids coassemble into compartments.

108 a drug depot encapsulating cationic polymer/nucleic acid complexes, facilitating the enhanced retent

109 atile new tool for constructing programmable nucleic acid components in medicine, nanotechnology, and

110 The nucleic acid concentration in OMVs exhibited a cellular

111 CDN "X" composed of four equilibrated nucleic acid constituents, AA', AB', BA', and BB', and t

112 enable antibody-level targeting using an all-nucleic acid construct.

113 demonstrated a potent IFN immunogenicity of nucleic acid-containing (NA-containing) amyloid fibrils

114 hia coli in high yields, free of protein and nucleic acid contamination.

115 As a consequence of increased nucleic acid content, this nanostructure architecture ex

116 y how modern biopolymers, e.g., peptides and nucleic acids, could have originated in the primitive en

117 a versatile method that applies a library of nucleic acids coupled to biocatalytic DNA machineries as

118 nt strategies that can be employed to target nucleic acid delivery specifically to tumor cells are di

119 al NAATs) have emerged as a popular tool for nucleic acid detection due to their high sensitivity and

120 and will help to improve the sensitivity of nucleic acid detection for low-abundance DNA biomarkers.

121 A promising new nucleic acid detection method is Clustered Regularly Int

122 Although nucleic acid detection methods such as reverse transcrip

123 , nanolitre droplets containing CRISPR-based nucleic acid detection reagents(7) self-organize in a mi

124 Fast, portable and automated nucleic acid detection should facilitate testing at the

125 itivity and specificity of LbCas12a-mediated nucleic acid detection.

126 odification, control of gene expression, and nucleic acid detection.

127 We demonstrate that SMOLT can detect nucleic acids directly in blood, urine and sputum at sub

128 idics by expanding the repertoire of current nucleic acid droplet assays to include functional phenot

129 herapy efficacy by prolonging the release of nucleic acid drug payload for sustained, long-term gene

130 are a crucial step toward understanding the nucleic acids duplexes unzipping kinetics variability, i

131 , some of which target the incoming, foreign nucleic acids e.g. restriction-modification (R-M) or CRI

132 crVIAs) also significantly muffle the single-nucleic-acid editing ability of the dCas13a RNA-editing

133 efficiently package and controllably release nucleic acids enable the development of safer and more e

134 f shapes and sizes, they are all composed of nucleic acid encapsulated into a protein capsid.

135 ugh the epidermal barrier typically excludes nucleic acid entry, topically applied, spherically arran

136 As a solution, we present a multicomponent nucleic acid enzymes (MNAzymes)-based system for singlep

137 od is compatible with commercially available nucleic acid extraction kits (i.e., from Qiagen) and a s

138 review summarizes the recent advances in POC nucleic acid extraction technologies.

139 agnostic test consists of three major steps: nucleic acid extraction, amplification, and amplicon det

140 ied sample preparation method independent of nucleic acid extraction, and showed that these assays ar

141 cleic acid sensors also recognize endogenous nucleic acids, for example when cells are damaged by gen

142 Innate immunity to nucleic acids forms the backbone for anti-viral immunity

143 Since this nucleic acid fraction originates mainly in apoptotic, se

144 Fine-tuning of such nucleic acid-free protein machines for precision medicin

145 ays with EUA for the detection of SARS-CoV-2 nucleic acid from clinical specimens.

146 In addition, we sequenced nucleic acids from 9 clinical isolates from Africa depos

147 Shotgun metagenomic sequencing can detect nucleic acids from bacteria, fungi, viruses, and/or para

148 t life may have started with a heterogeneous nucleic acid genetic system that included both RNA and D

149 post-synthetic and site-specific labeling of nucleic acids has increased significantly.

150 However, heat-triggered control of nucleic acids has remained largely unexplored, leaving a

151 Nucleic acids have not been widely considered as an opti

152 represents a distinct subgroup of Ski2-like nucleic acid helicases whose members comprise tandem hel

153 Classes of nucleic acids, hurdles that must be overcome for effecti

154 theses of d- or l-nucleoside analogs, locked nucleic acids, iminonucleosides, and C2'- and C4'-modifi

155 hitosan (QAC) for the intranasal delivery of nucleic acid immunogens to improve protective efficacy.

156 Detection of disease-associated, cell-free nucleic acids in body fluids enables early diagnostics,

157 Detection of microbial nucleic acids in body fluids has become the preferred me

158 The close synergy between peptides and nucleic acids in current biology is suggestive of a func

159 Detection of nucleic acids in genotypic AST can be rapid, but it has

160 nology now allows absolute quantification of nucleic acids in plasma.

161 piratory syndrome coronavirus 2 (SARS-CoV-2) nucleic acids in respiratory tract specimens informs pat

162 l Zalpha1 and Zalpha2 domains, which bind to nucleic acids in the Z-conformation.

163 r platform that uses real-time PCR to detect nucleic acids in up to 8 specimens at a time.

164 However, the kinetics and thermodynamics of nucleic acid interactions in a crowded environment remai

165 an also be used to reversibly disrupt enzyme-nucleic acid interactions, and we show that caging of gu

166 ilitate the delivery of functional bacterial nucleic acids into host cells.

167 l can be adapted to any NANPs or therapeutic nucleic acids, irrespective of whether they are carrier

168 Nucleic acid is purified using a pipet tip with an embed

169 ith the ability to detect viral or bacterial nucleic acids is individual for each DNA-modifying enzym

170 actions of biomolecules such as proteins and nucleic acids is key to understanding cellular life on t

171 Fluorescence detection of nucleic acid isothermal amplification utilizing energy-t

172 In this review, we discuss multivalent nucleic acid-ligand conjugates in the context of the bio

173 activity presentation of protein antigen and nucleic acid ligands critically limit the clinical devel

174 intrinsically disordered proteins (IDPs) and nucleic acids like RNA and other polynucleotides play a

175 Poly(ADP-ribose) (PAR) is a nucleic acid-like protein modification that can seed the

176 ion by the gapmer ASOs was blunted by locked nucleic acid (LNA) and 2'-methoxyethyl (2'MOE) modificat

177 RIC exploits the stronger binding of locked nucleic acid (LNA)-containing oligo(dT) probes to poly(A

178 ncRNA localization using biotinylated locked nucleic acid (LNA)-containing oligonucleotides with toeh

179 phorodiamidate morpholino oligomer or locked nucleic acids (LNA)/2'-OMe mixmers with different extent

180 s-specific electrochemical DNA probe (locked nucleic acid, LNA) was synthesized and implemented in a

181 established PNFs using anti-miR-155 peptide nucleic acid-loaded nanoparticles marginally decreased t

182 structural similarity between those and host nucleic acids, mammalian cells have been able to evolve

183 ific depletion of bacteria without employing nucleic acid manipulation and optical visualization devi

184 The wide clinical application of nucleic acid materials dependents on the development of

185 to the thermal cycling commonly employed for nucleic acid melting and annealing, this is achieved by

186 The tricarboxylic acid cycle and nucleic acid metabolism pathways were also negatively af

187 als fundamental insights into nucleotide and nucleic acid metabolism.

188 igh-throughput screening (HTS) of 997 locked nucleic acid miRNA inhibitors was performed in six chola

189 r enhancing the potency of ASOs with diverse nucleic acid modifications.

190 Colloidal crystal engineering with nucleic acid-modified nanoparticles is a powerful way fo

191 types of therapeutics, delivery vehicles for nucleic acids must also be designed to avoid unwanted si

192 efficient and safe delivery to cancer cells, nucleic acids must generally be packaged into a vehicle,

193 Nucleic acid (NA)-based treatments hold great potential

194 Nucleic acid nanoparticles (NANPs) have become powerful

195 tocol assesses proinflammatory properties of nucleic acid nanoparticles (NANPs) using a validated pre

196 ears and is frequently used to prototype new nucleic acid nanostructural designs, model biophysics of

197 include DNA/RNA nanotechnology, multivalent nucleic acid nanostructures, and nucleic acid aptamers,

198 speeding up strand displacement cascades in nucleic acid nanotechnology.

199 Experimental evidence supports the role of nucleic acids (NAs) in assisting this conversion.

200 ction, activating nucleases that degrade the nucleic acid of both invader and host.

201 ent HPV infection and HPV assays that detect nucleic acids of the virus.

202 Recently developed liposomal spherical nucleic acids overcome this barrier and enable topical d

203 Here we constrain nucleic acid/peptide interactions with model peptides th

204 o diesters may have enabled the synthesis of nucleic acids, perhaps opening a way into the RNA world.

205 red with a novel and highly specific peptide nucleic acid (PNA) as the recognition element.

206 it CE-based miRNA analysis utilizing peptide nucleic acid (PNA) hybridization probes.

207 n gene from maize using pyrrolidinyl peptide nucleic acid (PNA) immobilized on a magnetic solid suppo

208 To address this issue, we tested peptide nucleic acid (PNA), chemically modified RNA and their hy

209 Importantly, as in nucleic acids-processing enzymes, a positively charged a

210 this third ion has been observed in several nucleic-acid-processing metalloenzymes.

211 sis of live cells based on protein spherical nucleic acids (ProSNAs).

212 Telomeres comprise specialized nucleic acid-protein complexes that help protect chromos

213 , the CRISPR based biosensing strategies for nucleic acids, proteins and small molecules are summariz

214 pplications of BLAS include the detection of nucleic acids, proteins, and cancer cells, and potential

215 The base sequences comprising nucleic acids provide a rich "tool box" to assemble sign

216 ng conditions, rather than sequence-specific nucleic acid purification, is used to pull-down total RN

217 ein demonstrate a homogeneous and isothermal nucleic acid quantification strategy based on C2CA and o

218 ked two questions: (1) Is it possible to use nucleic acid quantification to measure the beta-lactam s

219 nalysis, enabling simple, rapid and reliable nucleic acid quantification without need for expensive f

220 auxiliary domains for multiple steps of the nucleic acid remodeling reactions.

221 se Collaboration (INSDC) (Cochrane G, et al, Nucleic Acids Res, 44:D48-50, 2016) - National Center fo

222 The 2020 Nucleic Acids Research Database Issue contains 148 paper

223 previous update manuscript was published in Nucleic Acids Research in 2017.

224 the structure and activity of virtually any nucleic acid scaffold.

225 Here, we describe a city-wide SARS-CoV-2 nucleic acid screening programme between May 14 and June

226 Nucleic acid sensing is a critical mechanism by which th

227 Dnase1l3(-/-) mice redundantly with another nucleic acid-sensing receptor, TLR7.

228 in 1 (ZBP1; also known as DAI or DLM-1) is a nucleic acid sensor that contains two Zalpha domains tha

229 to nonself DNA and RNA from microorganisms, nucleic acid sensors also recognize endogenous nucleic a

230 n the clinic, relatively few drugs targeting nucleic acid sensors are approved for therapeutic use.

231 ng RNA and DNA from either self or non-self, nucleic acid sensors mediate the pathogenesis of many au

232 utilizing agonists and antagonists targeting nucleic acid sensors to treat infectious disease, cancer

233 reated a dynamic web-based platform, NASQAR (Nucleic Acid SeQuence Analysis Resource).

234 epends on the environment, such as the local nucleic acid sequence and solvation.

235 When combined with isothermal nucleic acid sequence based amplification (NASBA), the a

236 his need by accomplishing broad-based, rapid nucleic acid sequence identification.

237 rained to predict the regulatory activity of nucleic acid sequences have revealed principles of gene

238 Guanine- and cytosine-rich nucleic acid sequences have the potential to form second

239 c unique is that, thanks to state-of-the-art nucleic acid sequencing technologies, we can follow in d

240 nalyte detection via the highly programmable nucleic acid shell or a functional protein core.

241 ion of immunotherapeutic liposomal spherical nucleic acids (SNAs) for TNBC therapy.

242 ed oligonucleotide nanoconjugates (spherical nucleic acids [SNAs]) penetrate mouse skin, three-dimens

243 Furthermore, a pyrrolidinyl peptide nucleic acid (so-called "acpcPNA") was used as a probe i

244 at originate from the detection of cytosolic nucleic acid species, one of the most prominent being th

245 Optimization and Redesign Model (STORM) and Nucleic-Acid Speech (NuSpeak), two orthogonal and synerg

246 impact of different protocols for fixation, nucleic acid staining and catalysed reporter deposition

247 '-OH groups to be accommodated without intra-nucleic acid steric conflicts.

248 lf-replicator consisted of both peptides and nucleic acid strands.

249 on is easily installed and potently disrupts nucleic acid structure and function.

250 formation remains a formidable challenge for nucleic acid structure determination.

251 R-loops are dynamic, co-transcriptional nucleic acid structures that facilitate physiological pr

252 amined the contribution of G-quadruplex (G4) nucleic acid structures to AID targeting in vivo.

253 ocks a valuable chemical space for targeting nucleic acid structures.

254 distinct subunits when designing artificial nucleic acid structures.

255 phosphorylation facilitates the increase in nucleic acid synthesis required for anabolic cell growth

256 , foreshadowing today's encapsulated peptide-nucleic acid system.

257 uld offer precise and rapid control of other nucleic acid systems.

258 unique two-color fluorescence signature to a nucleic acid target representing a clinically important

259 Quantification of nucleic acid targets at low copy number is problematic w

260 nanoparticle biosensor enables detection of nucleic acid targets using a smartphone coupled to an ap

261 led us to detect various clinically relevant nucleic acid targets with higher sensitivity, achieving

262 ility to recognize both nucleic acid and non-nucleic acid targets, ease of synthesis and chemical mod

263 ecular decoys of protein-binding partners or nucleic acid targets, while enzymatic suppressors covale

264 red, leaving a significant gap in responsive nucleic acid technology.

265 e transcription step of RT-qPCR with a rapid nucleic-acid-template-dependent DNA chemical ligation sy

266 ty by acquiring short pieces of the invading nucleic acid termed prespacers and inserting them into t

267 y (Abbott Laboratories), Cobas influenza A/B nucleic acid test (LIAT; Roche Molecular Systems, Inc.),

268 nd as early as the day of the first positive nucleic acid test after symptom onset.

269 available diagnostic evidence and recommends nucleic acid testing for all symptomatic individuals sus

270 The entire process of nucleic acid testing that involves sampling, extraction,

271 ospectively tested in 2394 NOPS by multiplex nucleic acid testing, including 1816 (75%) simultaneousl

272 o improve early accessibility of large-scale nucleic acid testing.

273 ed on infectious dose and the sensitivity of nucleic acid testing.

274 tive concentrations of proteins, lipids, and nucleic acids than PcO6 cells.

275 re small synthetic single-stranded chains of nucleic acids that target specific RNA transcripts throu

276 By interacting with proteins and nucleic acids, the vast family of mammalian circRNAs is

277 PS-modified nucleic acid therapeutics show improved metabolic stabil

278 an exciting new peptide for the delivery of nucleic acid therapeutics.

279 With the central role of nucleic acids there is a need for development of fluorop

280 The protein interacts with the PS nucleic acid through a network of electrostatic and hydr

281 ools due to the innate biological ability of nucleic acids to identify target molecules or silence ge

282 obes, antibodies, small-molecule agents, and nucleic acids to improve surgical outcomes in resectable

283 tic cells to transport lipids, proteins, and nucleic acids to the external environment have important

284 Improving the affinity of nucleic acids to their complements is an important goal

285 h cellular macromolecules (proteins, lipids, nucleic acids) to either modify their activity or, when

286 tanding of the mechanisms by which bacterial nucleic acids traffic extracellularly to trigger the mod

287 llowing M. tuberculosis infection, cytosolic nucleic acid transfection, and IFN-beta treatment.

288 ein surveillance complexes recognize foreign nucleic acids, triggering their destruction by Cas nucle

289 I, Roy et al. show that Abeta complexed with nucleic acids triggers an antiviral type I interferon re

290 et tip with an embedded matrix that isolates nucleic acid ("TruTip").

291 zymes, as its activity is independent of the nucleic acid type (RNA or DNA), its strandedness (single

292 to optimize the platform for the sensing of nucleic acids using a paper-based detection method.

293 ial surface protein that is commonly used in nucleic acid vaccines in multiple clinical trials.

294 Nucleic acid vaccines introduce the genetic materials en

295 Total nucleic acid was extracted from DBS, reverse transcribed

296 res can be calculated for atoms in proteins, nucleic acids, water, ligands and other solvent atoms, u

297 mers (<100 kDa) after enzymatic digestion of nucleic acids, whereas higher-order PrP assemblies deriv

298 develop the AIOD-CRISPR assay and detect the nucleic acids with a sensitivity of few copies.

299 e structural basis of the interactions of PS nucleic acids with proteins.

300 ate the visualization of processes involving nucleic acids without perturbing their natural propertie