ライフサイエンスコーパス: nucleic acid base

1 potential of 4-methylindole relative to the nucleic acid bases.

2 asure of aromatic stacking interactions with nucleic acid bases.

3 RNA due to stacking of its Trp residue with nucleic acid bases.

4 ations interact favorably with pi-systems of nucleic acid bases.

5 or their first hydration shells to faces of nucleic acid bases.

6 tadienes, substituted in the 4 position with nucleic acid bases 1-6, have been synthesized via Mitsun

7 at capacities of hydration (dCp) of the five nucleic acid bases A, G, C, T, and U, the sugars ribose

8 suggesting that the tryptophan stacking with nucleic acid base accompanies electrostatic contacts.

9 rtebrate animals, RNA silencing is a form of nucleic acid-based adaptive immunity.

10 repeat (CRISPR) are essential components of nucleic-acid-based adaptive immune systems that are wide

11 I CRISPR-Cas loci provide prokaryotes with a nucleic-acid-based adaptive immunity against foreign DNA

12 o observed for the intrinsic emission of the nucleic acid bases adenine and thymine and for single-st

13 Here, we show that nucleic acid bases adenine, cytosine, guanine, thymine,

14 Aptamers are nucleic acid-based affinity reagents that have been inco

15 Our results identified a new nucleic acid-based agent (CD8 aptamer-GNLY siRNA chimera

16 argeting GNLY(+) CTLs, we aimed to develop a nucleic acid-based agent consisting of an anti-CD8 aptam

17 Efforts to identify nucleic acid-based agents capable of more specifically m

18 al identification methods like culturing and nucleic acid-based amplification have limitations like p

19 Several nucleic acid-based amplification tests are available for

20 -care rapid tests for tuberculosis including nucleic acid-based amplification tests, imaging, and bre

21 Fluorescent nucleic acid base analogues are important spectroscopic

22 Molecular interaction between nucleic acid bases and amino acids is a fundamental proc

23 formations of DNA at the level of individual nucleic acid bases and base pairs is important for eluci

24 ms of the abiotic formation of the remaining nucleic acid bases and other biologically relevant molec

25 Sequencing both the nucleic acid bases and the positions of any 3'-O-thioate

26 irect consequence of oxidative damage to the nucleic acid bases and/or deoxyribose sugars.

27 ing rectangular block representations of the nucleic-acid bases and base pairs and all-atom models wi

28 ies and rigid-body parameters of interacting nucleic-acid bases and base-pair steps, the nucleotides

29 tion and quantification of the commonly used nucleic acid base- and sugar-protecting groups: benzoyl,

30 Conversely, locked nucleic acid-based anti-miR-34a treatment diminished pos

31 A silencing, implicating this mechanism as a nucleic acid-based antiviral immunity in mammalian cells

32 A nucleic acid-based approach to end-labelling is desirabl

33 Apart from nucleic acid based approaches, community proteomics has

34 overcome before applying the scaling used in nucleic acid based approaches.

35 Several compelling nucleic acid-based approaches have recently been develop

36 Existing gold standard nucleic acid-based approaches require enzymatic amplific

37 nogenic and immunoinhibitory molecules using nucleic acid-based approaches such as plasmid DNA (pDNA)

38 genome editing and the application of other nucleic acid-based approaches to influence the coagulati

39 Nucleic acid-based aptamers offer many advantageous feat

40 hort DNA-like oligomers in which the natural nucleic acid bases are replaced by interacting fluoresce

41 This site-size is independent of the type of nucleic acid base as well as the salt concentration and

42 dies, show that independently of the type of nucleic acid base, as well as salt concentration and typ

43 dies, show that independently of the type of nucleic acid base, as well as the salt concentration, th

44 A new nucleic acid-based assay (simple amplification-based ass

45 We compared a DNA-based assay with a total nucleic acid-based assay for early detection of infant h

46 We have developed a nucleic acid-based assay that is rapid, sensitive, and s

47 me platform, streamlining development of any nucleic acid-based assay.

48 ation of phenotypic, mass spectrometric, and nucleic acid-based assays and exhibited high-level resis

49 f the challenges faced by current methods of nucleic acid-based assays and symptom-based diagnosis, w

50 g novel DNA-based methodologies are adopted, nucleic acid-based assays depend critically on the quali

51 ble to those of other commercially available nucleic acid-based assays for these organisms.

52 creening of potential donors with the use of nucleic acid-based assays for West Nile virus may reduce

53 Among them immunoassays and Nucleic acid-based assays provide results within 24h, bu

54 ading to point-of-care kits that incorporate nucleic acid-based assays, including polymerase chain re

55 Point-of-care testing (POCT), particularly nucleic acid-based assays, is reshaping infectious disea

56 ent methods, such as antigen-based tests and nucleic acid-based assays.

57 g strain distribution present a challenge to nucleic acid-based assays.

58 Nucleic acids-based assays, particularly aptamers, have

59 Nucleic acid-based assemblies that interact with each ot

60 Previously studied nucleic acid-based automata include game-playing molecul

61 ying interactions of urea (component 3) with nucleic acid bases, base analogues, nucleosides, and nuc

62 Nucleic acid-based biochemical assays are crucial to mod

63 Nucleic acid-based biomarkers of allograft status have b

64 ry-immobilized SELEX to isolate new aptamers-nucleic acid-based bioreceptors that are well-suited for

65 c acid based pharmaceutical development, and nucleic acid based biosensor device design.

66 Functional nucleic acid-based biosensors are emerging tools that ar

67 presented here should be applicable to other nucleic acid-based biosensors to decrease background flu

68 Nucleic-acid-based biosensors have enabled rapid and sen

69 Photoelectrochemical detection of nucleic acid-based cancer biomarkers offers opportunitie

70 CSA tensors for protonated nucleic acid base carbons have been derived from measure

71 ties and functions by means of the synthetic nucleic-acid-based CDNs, the systems introduce versatile

72 ion of such analyte selectivity spectrum for nucleic acid-based chiral separation tools.

73 perimental scale of hydrophobicities for the nucleic acid bases, comparable with a scale developed ea

74 of functionally important RNAs to bind short nucleic acid-based compounds tightly and more specifical

75 y revisit several milestones in the field of nucleic acid-based computation, but also highlight how t

76 ranscribed/translated proteins, we introduce nucleic acid-based constitutional dynamic networks (CDNs

77 The emergence of nucleic acid-based constitutional dynamic networks, CDNs

78 nctionalities, we introduce the evolution of nucleic-acid-based constitutional dynamic networks (CDNs

79 Microarray-based multiplexing and nucleic-acid-based deep-sequencing methods allow simulta

80 ded when designing DNA hairpins as probes in nucleic acid based detection assays, such as microarrays

81 Nucleic acid-based detection methods are widely accepted

82 otential as a bio-specimen for non-invasive, nucleic acid-based detection of GI diseases.

83 he TaqMan assay with some of the alternative nucleic acid-based detection techniques of microarray, c

84 ostics has required the development of novel nucleic acid-based detection technologies that are sensi

85 systems has opened a new era in the field of nucleic acid-based detection.

86 The application of nucleic-acid based detection methods in seed health test

87 method is also needed for use with portable nucleic-acid-based detection methods.

88 ries to on-site testing, there is a need for nucleic acid based diagnostic tools combining the sensit

89 A typical nucleic acid-based diagnostic test consists of three maj

90 Diagnosis of tularemia by blood culture and nucleic acid-based diagnostic tests is insufficiently se

91 eir use in DNA-targeting applications within nucleic acid based diagnostics, therapeutics, and materi

92 able, and target amplification-free tool for nucleic acid based diagnostics.

93 vided their rationale for recommendations on nucleic acid-based diagnostics for viral pathogens other

94 lysis platform for rapid field deployment of nucleic acid-based diagnostics using consumer-class quad

95 in 13 (Cas13) has been rapidly developed for nucleic-acid-based diagnostics by using its characterist

96 e-chain dichotomy polar/nonpolar matches the nucleic acid base dichotomy purine/pyrimidine at the sec

97 ses controlling living systems, we introduce nucleic acid-based dissipative constitutional dynamic ne

98 d specific binding site for a synthetic, non-nucleic acid-based DNA binding molecule, but with a sign

99 homopurine ssRNAs indicates that the type of nucleic acid base dramatically affects the enzyme orient

100 n this review, we discuss recent progress in nucleic acid-based drug delivery strategies, their poten

101 fied nucleic acids, which are of interest in nucleic-acid-based drug development.

102 ents and stent coatings, conventional drugs, nucleic acid-based drugs and gene transfer.

103 spite the tremendous progress, there are few nucleic acid-based drugs for brain tumors in clinic.

104 Encouragingly, continuous nucleic acid-based drugs have been approved by the Food

105 d technologies for large-scale production of nucleic acid-based drugs have been exploited for various

106 Nucleic acid-based drugs, either as monotherapies or in

107 ns for enhancing the drug-like properties of nucleic acid-based drugs, including antisense oligonucle

108 logy, significantly reducing the lifetime of nucleic acid-based drugs.

109 ghest purity for therapeutic applications as nucleic acid-based drugs.

110 For a nucleic acid-based electrochemical sensor with signal-of

111 Nucleic acid-based electrochemical sensors (NBEs) can su

112 mitations and fully realize the potential of nucleic acid-based electrochemical sensors for healthcar

113 esents a comprehensive characterization of a nucleic acid-based endonuclease that prefers transition

114 will prove to be as useful and ubiquitous in nucleic-acid-based engineering as it is in biology.

115 ons of whether different tautomeric forms of nucleic acid bases exist to any significant extent in DN

116 ults demonstrate the potential of the locked nucleic acid bases for nucleic acid design for surface i

117 enetic code extension and the development of nucleic acid-based functional nanodevices, DNA duplexes

118 ence (EGS) bound to mRNA represents a unique nucleic acid-based gene interference approach for modula

119 h external guide sequence (EGS) represents a nucleic acid-based gene interference approach to knock-d

120 rapy is to develop approaches for delivering nucleic acid-based gene interfering agents, such as smal

121 and contrast the efficacies of a wide range nucleic acid-based gene silencing reagents in the skin o

122 tential as an effective non-viral vector for nucleic acid-based gene therapy.

123 First, we review the current and emerging nucleic acid-based gene-editing and delivery modalities.

124 ral issue for the therapeutic application of nucleic-acid-based gene interfering agents, such as ribo

125 resulted in the successful development of a nucleic acid-based high-performance bivalent protein inh

126 ter than those of the commercially available nucleic acid-based HIV-1 diagnostic tests.

127 -scenarios we considered that more sensitive nucleic-acid-based HIV diagnostic testing (NAT), rather

128 A method to assemble stimuli-responsive nucleic acid-based hydrogel-stabilized microcapsule-in-m

129 me and that natural HIV-1 infection provokes nucleic acid-based immunity in human cells.

130 d future opportunities in the development of nucleic acid-based immunotherapeutics.

131 arlo calculations of the association between nucleic acid bases in a nonpolar solvent (CCl4) are desc

132 A method to directly predict the number of nucleic acid bases in a single-stranded DNA (ssDNA) or a

133 n of NMR to investigate the base stacking of nucleic acid bases in solution, the dynamic structure of

134 AMR) gene panel is a qualitative, multiplex, nucleic acid-based in vitro diagnostic test for the dete

135 e played by the products of mutator genes in nucleic acid-based inheritance.

136 d perhaps be exploited in the development of nucleic acid-based inhibitors.

137 ith literature values for the free energy of nucleic acid base interactions as well as the calculated

138 le side chain of the tryptophan residue with nucleic acid bases is demonstrated by a characteristic a

139 transposases guarantee to thrive so long as nucleic acid-based life forms exist.

140 enerating the last universal ancestor of all nucleic-acid-based life.

141 a folded RNA that are accessible toward the nucleic acid-based ligand.

142 Aptamers are nucleic acid-based ligands that exhibit promising featur

143 s an impediment toward binding of the RNA by nucleic acid-based ligands.

144 Oligonucleotides containing locked nucleic acid bases (LNAs) have increased affinity for co

145 Essentially, this new design adds locked nucleic acid bases (LNAs) to the beacon structure, resul

146 e development of amplified DNA sensors using nucleic acid-based machineries, involving the isothermal

147 Nucleic acid-based markers may prove to be valuable tool

148 ion is yielding new and potentially powerful nucleic acid-based markers of neoplastic disease.

149 Nucleic acid-based materials enable sub-nanometer precis

150 rcoming obstacles to clinical translation of nucleic acid-based medications, including greater stabil

151 acy, these studies highlight that optimizing nucleic acid-based medicines for safety in humans presen

152 efficacy is crucial to the long-term use of nucleic-acid based medicines.

153 screens to identify in vivo functions of non-nucleic acid-based metabolites beyond their metabolic ro

154 proven to serve as an effective alternative nucleic acid-based method for foodborne pathogens.

155 d subgroup identifications were confirmed by nucleic acid-based methods and included nine group A and

156 acid probes to target cells is critical for nucleic acid-based methods to successfully image low-abu

157 Other nucleic acid-based methods were expensive and required t

158 or compensatory adaptation that can confound nucleic-acid-based methods that involve slow depletion o

159 study (SMART) was examined using an in vitro nucleic acid-based microarray.

160 is limited manufacturing expertise for these nucleic-acid-based modalities, especially in the develop

161 Nucleic acid-based molecular diagnosis reveals valuable

162 Nucleic acid-based molecular diagnostics are particularl

163 One of the major obstacles to implement nucleic acid-based molecular diagnostics at the point-of

164 RISPR-Cas technology has opened a new era of nucleic acid-based molecular diagnostics.

165 erged as a powerful tool for next-generation nucleic acid-based molecular diagnostics.

166 eloping technologies that are dependent upon nucleic acid-based molecular recognition.

167 Nucleic acid-based molecular tension probes allow one to

168 association events in RNA nanotechnology and nucleic-acid-based molecular computation.

169 elicase, and for simulations of a variety of nucleic-acid-based molecular motors.

170 truction of complex and functional synthetic nucleic acid-based nanoarchitectures, high-resolution di

171 owed the creation of a stunning diversity of nucleic acid-based nanodevices.

172 ts a new route in the development of 'smart' nucleic acid-based nanoparticles and switches for variou

173 aptamer switches into more complex synthetic nucleic acid-based nanostructures and functionalized sma

174 owledge will impact our understanding of how nucleic acid-based nanostructures, and SNAs in particula

175 the second section, the characterization of nucleic acid-based nanostructures, nucleic acid-function

176 Nucleic acid-based nanotechnology has always been percei

177 We report on the use of nucleic acid bases (NBs) in organic light emitting diode

178 Anionic states of guanine, which is the only nucleic acid base of which the anions have not yet been

179 we introduce a platform for the detection of nucleic acids based on a magnetic barcoding strategy.

180 To circumvent this problem, several nucleic acids based on amino-sugar nucleotides have been

181 rapid, sensitive and selective detection of nucleic acids based on an ionic diode feature of an anio

182 ws the detection and discrimination of small nucleic acids based on differences in their physical dim

183 In studies with synthesized nucleic acids based on the well-studied HIV mutation, K1

184 izing on our previous research on responsive nucleic acid-based organosilica nanoparticles, we combin

185 Nucleic acid based, out-of-equilibrium, dissipative netw

186 ended reference frame for the description of nucleic acid base pair geometry and a rigorous matrix-ba

187 Nucleic acid base pair open states that are actively dri

188 To investigate nucleic acid base pairing and stacking via atom-specific

189 owerful single-cell technique that harnesses nucleic acid base pairing to detect the abundance and po

190 acid sequence, the impact of the protein on nucleic acid base pairing, the end-to-end distance distr

191 d that salt stress affected the stability of nucleic acid base pairing.

192 rom the dominant role of hydrogen bonding in nucleic-acid base pairing, as well as in the secondary s

193 The rules of nucleic acid base-pairing have been used to construct na

194 ge in the enzyme, rather than the changes in nucleic-acid base-pairing that accompany backtracking.

195 or a covalently connected linear sequence of nucleic acid base pairs.

196 terization toward downstream applications in nucleic acid based pathogen detection.

197 As we will argue, future endeavors in nucleic acid-based pattern generation will be most great

198 Nucleic acid-based pattern recognition receptor agonists

199 ective inhibitory PCR (siPCR) using a locked nucleic acid-based PCR blocker to selectively inhibit th

200 biophysical insights into nuclear crowding, nucleic acid based pharmaceutical development, and nucle

201 ce reader, an important requirement toward a nucleic-acid-based point-of-care diagnostic system.

202 Furthermore, because these nucleic acid-based polymeric nanoparticles exhibited enh

203 ) building blocks have been combined to form nucleic acid-based polymeric nanoparticles without the n

204 rativity and enhanced specificity to improve nucleic acid based probe and drug design.

205 ichment (SELEX) method, which can generate a nucleic acid-based probe (aptamer) that possess numerous

206 may prove useful in the development of other nucleic acid-based probes for intracellular, toxicologic

207 ogy in constructing cell membrane-anchorable nucleic acid-based probes.

208 Recently, nucleic-acid-based probes have emerged as a promising pl

209 Oxidative damage to purine nucleic acid bases proceeds through quinoidal intermedia

210 the clinic remains modest compared to other nucleic acid-based products, such as thiophosphoryl and

211 have revealed that poly(ADP-ribose) (PAR), a nucleic acid-based protein modification catalyzed by ADP

212 ing SOMAmer (Slow Off-rate Modified Aptamer) nucleic acid-based protein-binding reagents allows for b

213 as well as 2,6-diaminopurine and the "core" nucleic acid bases purine and pyrimidine, are stable in

214 Expression of miRNA was determined by locked nucleic acid-based quantitative real-time polymerase cha

215 Here we report a powerful and versatile nucleic acid-based reagent-free electronic sensing syste

216 Aptamers are nucleic acid-based reagents that bind to target molecule

217 vious findings demonstrated the existence of nucleic acid-based receptors (Teazeled receptors, TezRs)

218 plex and subtly different analytes for which nucleic acid-based receptors exist.

219 A current limitation of protein- and nucleic acid-based recognition, however, is that the use

220 Nucleic acid-based replication has been pondered during

221 antitatively from the knowledge of component nucleic acid base resonance Raman cross sections.

222 ttings with limited capacity for specialized nucleic acid-based reverse transcription polymerase chai

223 Nucleic acid-based RNA detection is a promising field in

224 conjunction with routine chlamydia/gonorrhea nucleic acid-based screening are likely to have the most

225 powerful molecular recognition capabilities, nucleic acid-based self-assemblies represent a diverse t

226 TACs), which leverage the programmability of nucleic acid-based self-assembly for efficient synthesis

227 While previously reported nucleic acid-based self-replicating systems rely on pres

228 Special perspective is given to enhance nucleic acid-based sensor selectivity and sensitivity, w

229 Although nucleic acid-based sensors using EIS offer exceptional s

230 both polypeptide chain primary sequence and nucleic acid base sequence, control the two-phase coexis

231 est reported binding site for synthetic, non-nucleic-acid-based, sequence-specific DNA-binding molecu

232 should prove tractable as an alternative to nucleic-acid based sequencing for the multiplexed identi

233 However, nucleic acid-based small molecules have gained popularit

234 ncluding humanized monoclonal antibodies and nucleic acid-based strategies (antisense and RNA interfe

235 l as cell-type selectivity unavailable using nucleic acid-based strategies.

236 l expression patterns distinct from previous nucleic acid-based studies and identified new facets of

237 a specialized RNA-binding protein is a novel nucleic-acid-based surveillance mechanism of RQC.

238 APD-PCR and TaqMan assay offers promise as a nucleic acid-based system that can be used for the ident

239 In nucleic acids-based systems, stemming from DNA computati

240 To circumvent this problem, nucleic acid based techniques have been developed that e

241 Nucleic acid based techniques, such as quantitative PCR

242 procedures, such as immunological assays and nucleic acid-based techniques, Raman spectroscopy (RS) i

243 methods utilizing classical microbiology and nucleic acid-based techniques.

244 d this capacity lies at the heart of several nucleic acid-based technologies that are finding applica

245 As with other nucleic acid-based technologies, early efforts focused o

246 Control of protein levels by nucleic-acid-based technologies has proven to be a usefu

247 A second-generation signal amplification, nucleic acid-based test for the rapid detection and typi

248 viral loads undetectable by a gold standard nucleic acid-based test.

249 may provide a high-throughput alternative to nucleic acid-based testing for coronavirus disease 2019

250 The development of nucleic acid-based testing has demonstrated that viruses

251 However, HIV nucleic acid-based testing is widely used to screen for

252 tice guidelines on the diagnostic utility of nucleic acid-based testing of respiratory samples for vi

253 g whether routine diagnostics should include nucleic acid-based testing of respiratory samples for vi

254 irect evidence supporting a role for routine nucleic acid-based testing of respiratory samples in imp

255 Detection is usually done with nucleic acid-based tests (NATs) and rapid antigen tests

256 diagnostics, which could be integrated with nucleic acid-based tests and isothermal amplification ex

257 Nucleic acid-based tests for infectious diseases current

258 study was to evaluate three FDA-approved HPV nucleic acid-based tests for the ability to predict high

259 se polymerase chain reaction tests and rapid nucleic acid-based tests offer good performance in most

260 Nucleic acid-based tests were assumed to perform at 100%

261 We evaluated the ability of two FDA-cleared nucleic acid-based tests, the semiautomated respiratory

262 ing light microscopy, culture, serology, and nucleic acid-based tests.

263 micelles (CP-mag-micelles) that can deliver nucleic acid-based therapeutic agents and also provide m

264 dition to RNA-targeting small molecules, new nucleic acid-based therapeutic modalities that allow hig

265 ost widely investigated delivery systems for nucleic acid-based therapeutics and vaccines.

266 Advances in the formulation of nucleic acid-based therapeutics have rendered them a pro

267 DNAzymes represent a promising new class of nucleic acid-based therapeutics in cancer.

268 rovide safe and sustained release of various nucleic acid-based therapeutics with applications in bot

269 f messenger RNA (mRNA), an emerging class of nucleic acid-based therapeutics, have been poorly charac

270 CoV-2 vaccines have inaugurated a new era in nucleic acid-based therapeutics.

271 cal utility of DNA vaccines as well as other nucleic-acid-based therapeutics against viral infections

272 However, their compatibility with nucleic-acid-based therapeutics is not fully explored.

273 the lung, and remains a desirable route for nucleic-acid-based therapeutics.

274 therapeutics have led to the development of nucleic acid-based therapies (NATs) for prevention and t

275 ers, a number of chemotherapeutic agents and nucleic acid-based therapies are rapidly being synthesiz

276 Nucleic acid-based therapies can target disease pathways

277 Emerging nucleic acid-based therapies have potent Lp(a)-lowering

278 immense promise, the clinical realization of nucleic acid-based therapies is fundamentally constraine

279 Nevertheless, emerging nucleic acid-based therapies, such as the antisense olig

280 rgeted delivery platform for siRNAs or other nucleic acid-based therapies.

281 Nucleic acid-based therapy emerges as a powerful weapon

282 Herein, nucleic acid-based therapy for brain tumor is summarized

283 Nucleic acid-based therapy has emerged as a promising th

284 isense oligonucleotides to cells in culture, nucleic acid-based therapy is still often limited by the

285 3 nm light causes photoionisation of all the nucleic acid bases, these results indicate that guanine

286 vel DNA binding to investigate how RRMs bind nucleic acid bases through their highly conserved RNP co

287 l HSV-2 infection provided by an alternative nucleic acid-based TLR agonist, polyinosine-poly(C) (PIC

288 Several nucleic acid-based TLR3 agonists have been explored clin

289 mprove the accuracy of identification of the nucleic acid bases, to feed each released nucleotide int

290 In recent years, some useful nucleic-acid-based tools including antisense oligonucleo

291 and clinical activity of viral and non-viral nucleic acid-based treatments, including their mechanism

292 Establishing tautomerism of nucleic acid bases under physiological conditions has be

293 he COVID-19 pandemic accelerated progress in nucleic acid-based vaccine manufacturing, which spurred

294 Nucleic acid-based vaccines are effective in infectious

295 chnology platform for targeted gene editing, nucleic acid-based vaccines, and related biotherapeutic

296 and potent approach to substantially improve nucleic acid-based vaccines.

297 HEK293 tau biosensor cells, indicating that nucleic acid-based vectors can be used for inhibitor del

298 Design of nucleic acid-based viral diagnostics typically follows h

299 The protein environments around the two nucleic acid bases were significantly different, in term

300 4)/GNF/GCE was utilized for the detection of nucleic acid bases with a well resolved oxidation peak f