ライフサイエンスコーパス: nucleic acid binding

1 region (residues 150-183) is responsible for nucleic acid binding.

2 tion of SHOCT, including oligomerisation and nucleic acid binding.

3 onal transition to an ordered structure upon nucleic acid binding.

4 imal for high ( approximately 1 nM)-affinity nucleic acid binding.

5 with positive charge runs, are enriched for nucleic acid binding.

6 ntification of specific residues involved in nucleic acid binding.

7 hydration models for specific vs nonspecific nucleic acid binding.

8 ot use positive dipoles of alpha-helices for nucleic acid binding.

9 on is a prerequisite to, or a consequence of nucleic acid binding.

10 d with cell growth, signal transduction, and nucleic acid binding.

11 tions for alterations in enzyme activity and nucleic acid binding.

12 e molecular functions of kinase activity and nucleic acid binding.

13 main, perhaps pointing to a role for YloQ in nucleic acid binding.

14 e Rho protein that occur upon nucleotide and nucleic acid binding.

15 al residues for structural stability and for nucleic acid binding.

16 due W127 that likely acts through regulating nucleic acid binding.

17 Y182A mutations only moderately affected A3G nucleic acid binding.

18 at the KH domain in DDX43 is responsible for nucleic acid binding.

19 formation of a positively charged cavity for nucleic acid binding.

20 eatures for surface charge, dimerization and nucleic acid binding.

21 domain is required for maximal activity and nucleic acid binding.

22 ient folds and enriched for iron-sulfur- and nucleic acid-binding.

23 e domain of HP1gamma that confer protein and nucleic acid-binding ability are sufficient because they

24 sive molecular analysis of the deaminase and nucleic acid binding activities of human APO3G using a p

25 cytidine deaminase and single-stranded (ss) nucleic acid binding activities.

26 to further characterize A3A's deaminase and nucleic acid binding activities.

27 teins (MPs) generally lack sequence-specific nucleic acid-binding activities and display cross-family

28 main protein DPP1, which has single-stranded nucleic acid binding activity, suppresses heterochromati

29 -terminal region (C-1/3 domain) contains the nucleic acid binding activity.

30 Q772X, C772-1455, retains the differentiated nucleic acid-binding activity (RNA > ssDNA > dsDNA), ind

31 TEN domain unmasks a functionally important nucleic acid-binding activity in Est3.

32 Biochemical and NMR results establish the nucleic acid-binding activity of the Zf-GRF domain.

33 Using knock-in mice with disrupted ZBP1 nucleic acid-binding activity, we report that sensing of

34 We conclude that FUS has quite general nucleic acid-binding activity, with the various proposed

35 otein products localize to the nucleus, have nucleic-acid binding activity, and are involved in trans

36 nce anisotropy was used to determine protein-nucleic acid binding affinities for the RFX subunits and

37 ts of mutations in protein coding regions on nucleic acid binding affinities.

38 ults obtained for HIV-1 Gag, due to the weak nucleic acid binding affinity of the RSV MA domain, inos

39 hing analyses indicated that NC has a higher nucleic acid binding affinity than A3G, but more importa

40 rget cleavage; the binding groove, to modify nucleic acid binding affinity; and surface allosteric si

41 of the four cysteines to alanine diminished nucleic acid binding and catalytic activity.

42 structural features are compatible with the nucleic acid binding and chaperone activities of L1 ORF1

43 he two ORF1 proteins were purified and their nucleic acid binding and chaperone activities were exami

44 ain of retroviral Gag proteins in modulating nucleic acid binding and chaperone activity.

45 th RNase H2A in a complex ideally suited for nucleic acid binding and hydrolysis coupled to protein-p

46 terize the functional significance of IMPDH1 nucleic acid binding and its potential relationship to r

47 istent with the primary function of Gag as a nucleic acid binding and packaging protein and the prima

48 lin action in vertebrate cells, we performed nucleic acid binding and RNA interference studies.

49 These phenylalanines are critical for nucleic acid binding and the observed alternative side c

50 l processes were cellular and metabolic, and nucleic acid binding and transcription factor protein cl

51 Helicases couple ATP hydrolysis to nucleic acid binding and unwinding via molecular mechani

52 f rA3G-CD1 is important for oligomerization, nucleic acid binding and Vif-mediated degradation.

53 o two RNAP channels that are responsible for nucleic acids binding and substrate delivery to the acti

54 FOXP2 contains domains commonly involved in nucleic-acid binding and protein oligomerization, such a

55 conserved protein with domains homologous to nucleic-acid-binding and exonuclease proteins.

56 s have been studied extensively; the ATPase, nucleic acid binding, and helicase activities have been

57 g DAI or containing DAI mutants deficient in nucleic acid binding are resistant to IAV-triggered necr

58 ved in cellular signaling, organization, and nucleic acid binding are the most highly represented in

59 We also used direct telomerase activity and nucleic acid binding assays to explain how naturally occ

60 Nucleic acid binding assays using [(35) S]-labeled AtC3H

61 /visible spectroscopy, NMR spectroscopy, and nucleic acid binding assays.

62 The structure places the nucleic acid-binding ATPase domains of the helicase dire

63 -CD1) is responsible for oligomerization and nucleic acid binding, both of which are essential for an

64 We have investigated the energetics of nucleic acid binding by HCV helicase to understand how t

65 We observe two distinct modes of nucleic acid binding by mycobacterial PNPase: (i) metal-

66 ions may serve as a mechanism for regulating nucleic acid binding by RRM-containing proteins.

67 The Cp, via its nucleic acid-binding C-terminal domain, also affects nuc

68 BPCs, and its R3H domain, which has putative nucleic acid binding capabilities, to increase hTERT mRN

69 Based on its nucleic acid binding capacity, we propose a dual locatio

70 lso identified two water pockets beneath the nucleic acid-binding channel that appeared to stabilize

71 rroring that of AGO2, but not a well-defined nucleic acid-binding channel.

72 The nucleic-acid-binding channel between the PAZ- and PIWI-c

73 se DNA guide strand, thereby identifying the nucleic-acid-binding channel positioned between the PAZ-

74 ion segment, resulting in the opening of the nucleic-acid-binding channel.

75 1/L2 'hinge' and a subsequent opening of the nucleic-acid-binding channel.

76 he dynamic motions of Ago domains around the nucleic-acid-binding channel.

77 ently of sigma factor and away from the main nucleic-acids-binding channel of RNAP.

78 teract with RNAP at or near its three major, nucleic acid-binding channels: Mfd near the upstream ope

79 Rev can effectively compete with the general nucleic acid binding/chaperone functions of the nucleoca

80 n, signaling, metabolism, protein synthesis, nucleic acid binding, chromatin structure, protein foldi

81 l connecting the NNRTI-binding pocket to the nucleic acid-binding cleft.

82 The nucleic-acid-binding cleft of RNAP samples distinct conf

83 tiguous set of anti-parallel single-stranded nucleic acid binding clefts.

84 61) to elucidate the role of amine number on nucleic acid binding, complex formation, stability, and

85 for rapidly screening the selectivity of new nucleic acid binding compounds.

86 idyl-anthraquinones are a promising class of nucleic acid-binding compounds that act as NC inhibitors

87 OB and/or Zn-binding domains participate in nucleic acid binding consistent with a possible role for

88 asked whether a primordial function, such as nucleic acid binding, could emerge with ornithine, a bas

89 ggests that it can be developed as a modular nucleic acid binding device with general utility.

90 Pt(II) center can be developed as a modular nucleic acid binding device with general utility.

91 consisting of a targeted K16 peptide with a nucleic acid binding domain and plasmid-DNA, minicircle-

92 These experiments showed that NC (the nucleic acid binding domain derived from Gag) binds with

93 The nucleic acid binding domain of Nup475 consists of two CC

94 novel protein containing a putative OB-fold nucleic acid binding domain, is an integral component of

95 The amino terminus of E3L has a Z-form nucleic acid binding domain, which has been shown to be

96 ructurally repeated MTERF-motifs that form a nucleic acid binding domain.

97 It consists of a nucleic acid-binding domain and a protein-protein intera

98 and G4 J proteins by virtue of an additional nucleic acid-binding domain at the amino terminus.

99 y (RNA > ssDNA > dsDNA), indicating that the nucleic acid-binding domain of FANCA is located primaril

100 An NPM mutant lacking its carboxyl-terminal nucleic acid-binding domain oligomerizes with endogenous

101 The K-homology (KH) domain is a nucleic acid-binding domain present in many proteins but

102 The K-homology (KH) domain is a nucleic acid-binding domain present in many proteins.

103 en the integrin-binding ligand and the K(16) nucleic acid-binding domain to promote intracellular dis

104 cleic acid, but replacement of its principal nucleic acid-binding domain with a dimerizing leucine zi

105 most common change, S34F, alters a conserved nucleic acid-binding domain, recognition of the 3' splic

106 wer affinity to ssRNA, making it a versatile nucleic acid-binding domain.

107 ing hydrolases (e.g. NlpC/P60 peptidases) or nucleic acid binding domains (e.g. Zn-ribbons).

108 study demonstrate that affinities of various nucleic acid binding domains for ASO depend on chemical

109 D-associated TDP-43 mutations in the central nucleic acid binding domains lead to elevated half-life

110 ify multivalency of acidic tracts and folded nucleic acid binding domains, mediated by N-terminal dom

111 related, but non-identical, K-homology (KH) nucleic acid binding domains.

112 with reverse transcriptase, endonuclease and nucleic acid binding domains.

113 -inducible tumor-associated protein, harbors nucleic acid-binding domains for left-handed helix (Z-fo

114 e between RapA's SWI/SNF and double-stranded nucleic acid-binding domains significantly alter ATP hyd

115 ivity, coordinated by two spatially distinct nucleic acid-binding domains.

116 function that contains DNA/RNA helicase and nucleic acid-binding domains.

117 construct consists of two domains similar to nucleic acid-binding domains.

118 reverse transcriptase, DNA endonuclease and nucleic acid-binding domains.

119 reverse transcriptase, DNA endonuclease and nucleic acid-binding domains.

120 h they may still be capable of high affinity nucleic acid binding, duplex destabilization, and/or nuc

121 with a femtosecond-pulsed laser to bleach a nucleic acid-binding dye causing dose-dependent apoptosi

122 ide binding to this site functionally alters nucleic acid binding, electrophoretic mobility shift ass

123 Interior nucleic acid-binding elements spiral around six bases of

124 antitermination in vitro is determined by a nucleic acid binding equilibrium with one molecule of N

125 The area spans the nucleic acid binding face of the OB fold, including the

126 c residues on the protein surface suggests a nucleic acid-binding function.

127 conservation in fungi and an enrichment for "nucleic acid-binding" function.

128 Our studies reveal differences in the nucleic acid binding groove that could have implications

129 The nucleic acid binding groove was further mapped by chemic

130 portant insertions that result in a narrower nucleic acid binding groove.

131 thepsin B, connected to oligo-(L)-lysine for nucleic acid binding, (ii) pHCath(D)K(10), containing th

132 Nucleic acid-binding innate immune receptors such as Tol

133 ata presented here suggest that the specific nucleic acid binding interactions of Tat and Rev can eff

134 uggests that these residues line a potential nucleic acid-binding interface.

135 Thus, high-affinity nucleic acid binding is a conserved and functionally imp

136 nient and practical tool for identifying new nucleic acid-binding ligands.

137 logical activity through proper targeting of nucleic acids binding ligands or drug molecules.

138 function predictions that cover protein and nucleic acids binding, linkers, and moonlighting regions

139 Here, we discuss how nucleic acid binding might influence protein misfolding

140 SL2-4), consistent with their characteristic nucleic acid binding modes.

141 ndle with homology to the structure-specific nucleic acid binding module of RecQ helicases.

142 a single open reading frame with a putative nucleic acid binding motif (CCHC) and restriction enzyme

143 Several variants of a nucleic acid binding motif (RRM1) of putative transcript

144 that C-Ala forms an ancient single-stranded nucleic acid binding motif that promotes cooperative bin

145 ch could represent a nuclear localization or nucleic acid binding motif, and a pair of CXXC motifs th

146 The PUR domain is a nucleic acid-binding motif found in critical regulatory

147 nd elongated protein, with several potential nucleic acid binding motifs clustered at one end, includ

148 in sequence and in the lack of recognizable nucleic acid binding motifs.

149 Furthermore, nucleic acid binding mutants destabilize the association

150 We present an automated approach to predict nucleic-acid-binding (NA-binding) proteins, specifically

151 we report the structure of two single-strand nucleic acid-binding OB-folds from interaction proteins

152 for screening compounds that may inhibit the nucleic acid binding or elongation activities of polymer

153 RNAP, away from the catalytic center and the nucleic acid binding path.

154 ains as modules to construct single-stranded nucleic acid binding peptides.

155 n shell interactions within ZBDs, as well as nucleic acid binding, play important roles in determinin

156 s random binding of charged molecules to the nucleic acid-binding pocket and coordinates nucleic acid

157 D2 contains a nucleic-acid-binding pocket that is formed by conserved

158 These studies indicate that nucleic acid-binding polymers are able to scavenge effec

159 Previously, we demonstrated that nucleic acid-binding polymers can act as molecular scave

160 Herein we demonstrate that certain nucleic acid-binding polymers can inhibit activation of

161 anticoagulant and antithrombotic activity of nucleic acid-binding polymers in vitro and in vivo.

162 Full spectra of nucleic acid binding preferences were determined by comp

163 make important contributions to many protein-nucleic acid binding processes.

164 The results suggested that nucleic acid binding promotes a structural change of the

165 addition, AL2/L2 suppression phenotypes and nucleic acid binding properties are shown to be differen

166 ), the first of which has been shown to have nucleic acid binding properties in vitro.

167 We have probed the nucleic acid binding properties of a yeast protein, Nab2

168 is determined by critical differences in the nucleic acid binding properties of A3G, NC and RT.

169 how that these activities correlate with the nucleic acid binding properties of F/E.

170 o this role, several reports have implicated nucleic acid binding properties to retroviral MAs.

171 ere prepared, and catalytic efficiencies and nucleic acid binding properties were compared with the w

172 beta share substantial sequence homology and nucleic acid binding properties, genomic promoter and ci

173 er understanding of APOBEC3A's deaminase and nucleic acid-binding properties, which is central to its

174 lter the recently identified single-stranded nucleic acid binding property of IMPDH.

175 king the shell-forming 'core' domain and the nucleic acid-binding 'protamine' domain, has such a role

176 We recently demonstrated that Cellular Nucleic acid Binding Protein (CNBP)(-/-) mouse embryos e

177 by disruption of the gene encoding cellular nucleic acid binding protein (CNBP); Cnbp transgenic mic

178 ecific interaction between AGIL and cellular nucleic acid binding protein (CNBP/ZNF9), a zinc-finger

179 of the TJ-associated protein ZO-1-associated nucleic acid binding protein (ZONAB) were evaluated usin

180 e Y-box transcription factor ZO-1-associated nucleic acid binding protein (ZONAB).

181 ZO-1-associated nucleic acid binding protein (ZONAB)/DbpA is a Y-box tra

182 rgenic region on chromosome 2q32.3, close to nucleic acid binding protein 1 (most significant single

183 study, we associated polymorphisms close to nucleic acid binding protein 1 (which encodes a DNA-bind

184 In this study, we show that Z-form nucleic acid binding protein 1 (ZBP1; also known as DAI)

185 ulatory protein (KHSRP) is a multifunctional nucleic acid binding protein implicated in key aspects o

186 ecificity of these proteases for cleavage of nucleic acid binding protein substrates that play essent

187 Translin is a recently identified nucleic acid binding protein that appears to be involved

188 YB-1 is a nucleic acid binding protein that regulates transcriptio

189 The human DEK proto-oncogene is a nucleic acid binding protein with suspected roles in hum

190 CCUG repeats also decrease amounts of the nucleic acid binding protein ZNF9.

191 3L (a membrane scaffold protein), and L4R (a nucleic acid binding protein).

192 (Bvht), and its complex with CNBP (Cellular Nucleic acid Binding Protein).

193 SE) binding protein (FBP), a single-stranded nucleic acid binding protein, is recruited to the c-myc

194 trated by genetic perturbation that cellular nucleic acid-binding protein (CNBP) and La-related prote

195 n-coding region of the CCHC-type zinc finger nucleic acid-binding protein (CNBP) gene.

196 in various organisms suggests that cellular nucleic acid-binding protein (CNBP) plays a fundamental

197 Y-box transcription factor, ZO-1-associated nucleic acid-binding protein (ZONAB), in a GTP-dependent

198 other RHIM-containing signaling adaptors, Z-nucleic acid-binding protein 1 (ZBP1) (also called DAI a

199 and functionally characterized the borrelial nucleic acid-binding protein BpuR, a PUR domain-containi

200 o contains multiple structural alignments of nucleic acid-binding protein families with annotations o

201 eport evidence that ribosomal protein S1 and nucleic acid-binding protein Hfq copurify in molar ratio

202 tivity associated with the Sm-like hexameric nucleic acid-binding protein Hfq.

203 psid (NC) protein of retroviruses is a small nucleic acid-binding protein important in virion assembl

204 protein related to the human single-stranded nucleic acid-binding protein Pur-alpha, as a component o

205 ese changes also affected the degradation of nucleic acid-binding protein substrates of Lon, intracel

206 us nuclear ribonucleoprotein K (hnRNPK) is a nucleic acid-binding protein that acts as a docking plat

207 em by coding for a highly positively charged nucleic acid-binding protein that is packaged along with

208 om Escherichia coli K12 is a single-stranded nucleic acid-binding protein that plays a role in chromo

209 It should facilitate the identification of a nucleic acid-binding protein within approximately 4 d.

210 Here, we find that PRC2 interacts with the nucleic acid-binding protein Ybx1.

211 conservation, suggest that RbfA is indeed a nucleic acid-binding protein, and identify a potential R

212 TAR DNA-binding protein 43 (TDP-43) is a nucleic acid-binding protein, and its aggregation repres

213 regulates AR at this site, we identified the nucleic acid-binding protein, heterogeneous nuclear ribo

214 is testicular variant of the multifunctional nucleic acid-binding protein, KSRP, serves as a decay-pr

215 as a G4 quadruplex and purine motif triplex nucleic acid-binding protein.

216 y leading from a polypeptide to a ubiquitous nucleic acid-binding protein.

217 ty is allied to conversion of the endogenous nucleic-acid-binding protein PrP to an infectious modifi

218 A family of cellular nucleic acid binding proteins (CNBPs) contains seven Zn(

219 eviously, we have identified ZO-1-associated nucleic acid binding proteins (ZONAB), a Y-box transcrip

220 e role of metal ions in the function of both nucleic acid binding proteins and their enzymes.

221 tion termination factor (mTERF) proteins are nucleic acid binding proteins characterized by degenerat

222 glutamate on DNA binding by Escherichia coli nucleic acid binding proteins has been extensively docum

223 We performed a biochemical screen for novel nucleic acid binding proteins present in cell extracts o

224 ucleoproteins (hnRNPs) are a large family of nucleic acid binding proteins that are often found in, b

225 Many nucleic acid binding proteins use short peptide sequence

226 Instead, they are highly enriched in nucleic acid binding proteins with large intrinsically d

227 Many known Gzm substrates are nucleic acid binding proteins, and the Gzms accumulate i

228 is a member of a previously unknown class of nucleic acid binding proteins, composed of a single glob

229 ences were overrepresented by those encoding nucleic acid binding proteins, cytoskeleton components,

230 es affinity distributions of highly specific nucleic acid binding proteins.

231 of the function of individual KH domains in nucleic acid binding proteins.

232 hed to influence the activity of nuclear and nucleic acid binding proteins.

233 ods and findings can be generalized to other nucleic acid binding proteins.

234 ity it may prove possible to better engineer nucleic acid binding proteins.

235 ing proteins such as U1A than other types of nucleic acid binding proteins.

236 ffective means of modulating the behavior of nucleic acid binding proteins.

237 iptional functions for these single stranded nucleic acid binding proteins.

238 entify human cDNAs that encode a spectrum of nucleic acid-binding proteins (NBPs).

239 Many nucleic acid-binding proteins and the AAA+ family form h

240 Nucleic acid-binding proteins are involved in a great nu

241 ly, one of the most evolutionarily conserved nucleic acid-binding proteins currently known.

242 Predicting the affinity profiles of nucleic acid-binding proteins directly from the protein

243 -shock proteins (Csps) are a family of small nucleic acid-binding proteins found in 72% of sequenced

244 the most evolutionarily conserved family of nucleic acid-binding proteins known among bacteria, plan

245 or belonging to a family of highly conserved nucleic acid-binding proteins related by their ability t

246 ding proteins (PCBPs) constitute a family of nucleic acid-binding proteins that play important roles

247 mune complexes that incorporate DNA, RNA, or nucleic acid-binding proteins that serve as autoadjuvant

248 ctures of human Puf-A that reveal a class of nucleic acid-binding proteins with 11 PUM repeats arrang

249 parallel with the separation that delineates nucleic acid-binding proteins, although most of the inso

250 structural abnormalities and the presence of nucleic acid-binding proteins, including the TAR DNA bin

251 ators of posttranslational modification, and nucleic acid-binding proteins.

252 uses these mobility differences to identify nucleic acid-binding proteins.

253 e acting protein was in the hnRNPA family of nucleic acid-binding proteins.

254 for affinity microcapture of site-specific, nucleic acid-binding proteins.

255 ivates Rho signifies that the specificity of nucleic-acid binding proteins is defined not only by the

256 the sequence-specificity of single-stranded nucleic-acid-binding proteins (SNABPs).

257 Nucleic-acid-binding proteins are generally viewed as ei

258 psulation of cellular proteins, particularly nucleic-acid-binding proteins.

259 o acid residues, are present in a variety of nucleic-acid-binding proteins.

260 Furthermore, nucleic acid binding provides an elegant and simple mech

261 The nucleic acid binding region of TTP is comprised of two C

262 1071 to 1178 within the previously annotated nucleic acid-binding region (NAB) of severe acute respir

263 This work uncovers a mechanism wherein viral nucleic acid binding releases an inhibitory innate recep

264 ying article, three short sequence segments (nucleic acid binding sequences (NBS)) important for RNas

265 ntified to have perturbed pK(a)s in both the nucleic acid binding site and in the distant ATP-binding

266 mutants further demonstrate that the primary nucleic acid binding site corresponds to a surface of th

267 ne, which reveals a novel positively charged nucleic acid binding site distal to the active center th

268 We conclude that the nucleic acid binding site in plant POT1 proteins is evol

269 fferent heterodimer was formed involving the nucleic acid binding site of BolA and the C-terminal tai

270 The results of this study indicate that the nucleic acid binding site of HCV helicase is allosterica

271 studies determine the location of a defined nucleic acid binding site on a large, native, multi-subu

272 fragment has been modeled into the RNase H2 nucleic acid binding site providing insight into the rec

273 al of the C-terminal domain of gp32 from its nucleic acid binding site that is in pre-equilibrium to

274 these residues are part of the HCV helicase nucleic acid binding site, and their roles were analyzed

275 he helicase dictates the conformation of its nucleic acid binding site.

276 clude that RNA or DNA binding to the primary nucleic acid binding sites causes conformational changes

277 s with dsDNA due to the presence of multiple nucleic acid binding sites identified both in the isolat

278 is a result of RNA contacting the secondary nucleic acid binding sites in the central channel of the

279 of displacing natural polyamines from their nucleic acid binding sites, and of inhibiting cell divis

280 d allosteric cross-talk between the ATP- and nucleic acid-binding sites achieved by the overall stabi

281 These findings provide proof of concept that nucleic acid binding small molecules, such as TMPyP4, ca

282 acids, it has proven possible to adapt other nucleic acid binding species (aptamers) to function in a

283 Brg1 helicase has dual nucleic-acid-binding specificities: it is capable of bin

284 ic acids by intercalation, but the trends in nucleic acid binding specificity are highly diverse.

285 As a consequence, nucleic acid binding stimulates the rate at which a heli

286 Our structure and nucleic acid-binding studies also provide insight into t

287 common alpha/beta fold but exhibit different nucleic acid binding surfaces and distinct functional ro

288 of Molecular Cell reported that the typical nucleic acid binding surfaces of the RRM and winged-heli

289 an additional role for the p51 C terminus in nucleic acid binding that is compromised by inhibitor bi

290 ing was for the HOS determination of protein/nucleic acid binding, the concept was later adapted to M

291 By uncovering the molecular mechanisms of nucleic-acid binding, this study contributes to understa

292 that exploits the use of aqueous buffers for nucleic acid binding to and release from a solid phase i

293 The pH-controlled approach, which promotes nucleic acid binding to and release to the chitosan phas

294 We apply the method to the case of nucleic acids binding to silver, discovering that multip

295 c93b1 3d mutation that selectively abolishes nucleic acid-binding Toll-like receptor (TLR) (TLR3, -7,

296 ty and/or the specificity of single-stranded nucleic acid binding were altered for each IMPDH1 mutant

297 ing domain are required for processivity and nucleic acid binding, which leads to dimerization of the

298 s have been implicated in structure-specific nucleic acid binding with roles in targeting RecQ protei

299 he hallmark GxxG loop (GxxG-to-GDDG) impairs nucleic acid binding without compromising the stability

300 protein, E3, which contains an N-terminal Z-nucleic acid binding (Zalpha) domain that is critical fo