ライフサイエンスコーパス: nucleic acid structure

1 far in the context of a chemical etiology of nucleic acid structure.

2 chromicity of the oligonucleotide or complex nucleic acid structure.

3 This too can be enhanced by nucleic acid structure.

4 key factor in the energetics that determines nucleic acid structure.

5 termination of this particularly significant nucleic acid structure.

6 een used for many years to investigate local nucleic acid structure.

7 distinct subunits when designing artificial nucleic acid structures.

8 ractions and potentially for designing novel nucleic acid structures.

9 olypurine tract and other A-tract-containing nucleic acid structures.

10 ction and visualization of three-dimensional nucleic acid structures.

11 erentially insert adjacent to triple-helical nucleic acid structures.

12 SCHNAaP, for the analysis of double-helical nucleic acid structures.

13 l information concerning the perturbation of nucleic acid structures.

14 treamlined the analysis and annotation of 3D nucleic acid structures.

15 the hydrating water molecules in protein and nucleic acid structures.

16 ion receptors, including sensors of aberrant nucleic acid structures.

17 aminase AID, transcription, and noncanonical nucleic acid structures.

18 eoretical models for simulating noncanonical nucleic acid structures.

19 show that only the pathogenic forms unusual nucleic acid structures.

20 motor domain are amplified and redirected by nucleic acid structures.

21 ionalities and enable the formation of novel nucleic acid structures.

22 ing well reflects the hierarchical nature of nucleic acid structures.

23 ocks a valuable chemical space for targeting nucleic acid structures.

24 nding sites, aside from those sequestered by nucleic acid structures.

25 s a mechanism to prevent recognition of self nucleic acid structures.

26 DNA repair and transcription process complex nucleic acid structures.

27 nd intrinsic phosphorus SAD to solve complex nucleic acid structures.

28 of F(Py)...H-C(Pu) pseudo hydrogen bonds in nucleic acid structures.

29 n of transcription, we have investigated two nucleic acid structures.

30 re frequently occurring structural motifs in nucleic acid structures.

31 erized as selective ligands for higher-order nucleic acid structures.

32 yze, rebuild and visualize three-dimensional nucleic-acid structures.

33 obtain the footprint of bound proteins onto nucleic acids structures.

34 G-Quadruplexes, noncanonical nucleic acid structures, act as silencers in the promote

35 ates are used as research tools for studying nucleic acid structure and binding interactions.

36 otonation can play an important role in both nucleic acid structure and catalysis.

37 Nucleic acid structure and dynamics are known to be clos

38 powerful means of obtaining high-resolution nucleic acid structure and dynamics information that fav

39 ctional spectroscopic probe for the study of nucleic acid structure and dynamics using electron param

40 We study protein and nucleic acid structure and dynamics using single-molecul

41 ine and adenosine and has been used to probe nucleic acid structure and dynamics.

42 e role of oxygen and unsaturated moieties in nucleic acid structure and emphasizes greater use of thi

43 lies EDD has promise for characterization of nucleic acid structure and folding.

44 ive incorporation of 2'-5' linkages, whereby nucleic acid structure and function may be probed throug

45 agents and as analogues for the analysis of nucleic acid structure and function.

46 A, it should prove very useful in studies of nucleic acid structure and function.

47 is pushing back the supposed limitations of nucleic acid structure and function.

48 on is easily installed and potently disrupts nucleic acid structure and function.

49 onic strengths, tracing these differences to nucleic acid structure and ion type.

50 ly from higher eukaryotes in many aspects of nucleic acid structure and metabolism.

51 ds and are valuable reagents in the study of nucleic acid structure and protein-nucleic acid interact

52 nderscore the sensitivity of CT chemistry to nucleic acid structure and structural dynamics.

53 linked to the stability of the SAM layer and nucleic acid structure and the packing density of the nu

54 Nucleobase modifications dramatically alter nucleic acid structure and thermodynamics.

55 egulation, including recruitment to specific nucleic acid structures and association with protein act

56 suggesting possible applications in probing nucleic acid structures and biochemical mechanisms.

57 ude a ligand in the input structure, process nucleic acid structures and generate a solvent box with

58 or the PDB, has also been enhanced to handle nucleic acid structures and multi-chain complexes.

59 to be a single access point for protein and nucleic acid structures and related information.

60 predict experimental observations for other nucleic acid structures and salt conditions, demonstrati

61 tituted aromatic diamidine compounds with 13 nucleic acid structures and sequences.

62 Although an increasing number of nucleic acid structures and their complexes with protein

63 tal providing access to information about 3D nucleic acid structures and their complexes.

64 t base analogs (FBAs) are powerful probes of nucleic acids' structures and dynamics.

65 is problem is the lack of information on the nucleic acid structure, and distribution of transcripts

66 eractions, molecular dynamics simulations of nucleic acid structure, and two databases of super-enhan

67 It is known that sequence motifs, nucleic acid structures, and associated co-factors affec

68 and strong interactions of U2AF1 with these nucleic acid structures, and established a biochemical r

69 tions from experimentally determined protein-nucleic acid structures, and provides users with a graph

70 ts particularities when studying noncovalent nucleic acid structures, and then review what has been l

71 these findings on the use of pdC to examine nucleic acid structure are discussed.

72 Photolabile nucleotides that disrupt nucleic acid structure are useful mechanistic probes and

73 Four-stranded G-quadruplex nucleic acid structures are of great interest as their h

74 ons, which are characteristic of base paired nucleic acid structures, are abolished when the covalent

75 at sensitivity of Fe.bleomycin to changes in nucleic acid structure argues that those species which d

76 e identified a significant distortion in the nucleic acid structure at the HIV-1 PPT/U3 junction in t

77 physical technique capable of characterizing nucleic acid structures at atomic resolution under near-

78 es activation upon association with specific nucleic acid structures at DNA replication forks.

79 ote TRF2-mediated trans and cis higher-order nucleic acid structures at telomeres.

80 Telomeres are the protein-nucleic acid structures at the ends of eukaryote chromos

81 tention has been given to the development of nucleic acid structures based on non-natural DNA polymer

82 ll appreciated that PARP1 recognizes several nucleic acid structures beyond DNA lesions, including st

83 robably was not an effect due to the altered nucleic acid structure, but was more likely a general ef

84 ch analysis can be extended to non-canonical nucleic acid structures, but this approach has not been

85 ndent route for determining carbohydrate and nucleic acid structure by NMR spectroscopy.

86 d interactions and ligand-induced changes in nucleic acid structure by separately resolving the intri

87 s the types of base pairs that are formed in nucleic acid structures by various combinations of the t

88 are able to adopt noncanonical four-stranded nucleic acid structures called G-quadruplexes (G4s).

89 Four-stranded nucleic acid structures called G-quadruplexes have been

90 stabilization of secondary and higher-order nucleic acid structure can be more fully understood once

91 the suppression of R-loops, triple-stranded nucleic acid structures composed of a DNA:RNA hybrid and

92 R-loops are three-stranded nucleic acid structures composed of an RNA:DNA hybrid an

93 R-loops, three-stranded nucleic acid structures comprising a DNA:RNA hybrid and

94 dx41 suppresses the accumulation of R-loops, nucleic acid structures consisting of RNA:DNA hybrids an

95 l aptamer, which represents a highly compact nucleic acid structure, contains a wealth of new conform

96 a liver-targeting delivery system, tripodal nucleic acid structure demonstrated enhanced fluorescent

97 formation remains a formidable challenge for nucleic acid structure determination.

98 stablished methods to generate new tools for nucleic acid structure determinations.

99 w insights into the molecular recognition of nucleic acid structures emerged from these studies, addi

100 earest neighbor model representation and (v) nucleic acid structure flexibility.

101 l evidence suggests that these non-canonical nucleic acid structures form in vivo and play biological

102 gathered suggesting that these non-canonical nucleic acid structures form in vivo and play essential

103 d transcription and to elucidation of unique nucleic acid structures formed at this origin.

104 R-loops are nucleic acid structures formed by an RNA:DNA hybrid and

105 plex DNA (G4-DNA), a family of non-canonical nucleic acid structures formed by certain G-rich sequenc

106 There is increasing evidence that nucleic acid structures formed by the C9-NRE may both co

107 R-loops are three-stranded nucleic acid structures formed from the hybridization of

108 R-loops are three-stranded nucleic acid structures formed upon annealing of an RNA

109 Prediction of nucleic acid structure from sequence requires thermodyna

110 gram, SCHNArP, for rebuilding double-helical nucleic acid structures from a set of helical parameters

111 ing applications aimed at the elucidation of nucleic acid structure-function relationships.

112 nucleic acid labelling, the stabilization of nucleic acid structures, functionalization of nucleic ac

113 to uncover the biology of the four-stranded nucleic acid structure G-quadruplex (G4) via their stabi

114 ealing refinement can have a major impact on nucleic acid structures generated from NMR data.

115 Studies of nucleic acid structure have shown little differences in

116 Sugar puckering of nucleosides impacts nucleic acid structures; hence their biological function

117 has far-reaching biological implications for nucleic acid structure in a partially solvated cellular

118 conformation, temperature and non-canonical nucleic acid structures in live cells and other relevant

119 of this additional information: for example, nucleic acid structures in non-canonical conformations a

120 he small angle neutron scattering profile of nucleic acid structures in solution.

121 Tests on all nucleic acid structures in the Protein Data Bank confirm

122 to the ever-expanding archive of protein and nucleic acid structures in the worldwide Protein Data Ba

123 , high-affinity probes of the role of bulged nucleic acid structures in various biological processes.

124 se transcription, most likely in maintaining nucleic-acid structure in the complex.

125 RING-MaP single-molecule nucleic acid structure interrogation enables concise and

126 G-quadruplexes (G4) are alternative nucleic acid structures involved in transcription, trans

127 A fundamental motif in canonical nucleic acid structure is the base pair.

128 table in vivo formation of these alternative nucleic acid structures is likely to be highly dependent

129 fically interacts with stable, non-canonical nucleic acid structures known as G-quadruplexes.

130 taxin, generates a shield comprising triplex nucleic acid structures known as R-loops at intergenic s

131 versity, suggesting how compact or elongated nucleic acid structures may be constructed using differe

132 Moreover, computational methods for nucleic acid structure modeling are relatively scarce.

133 ne the impact of CH...O bonds on protein and nucleic acid structure, molecular recognition, and enzym

134 een used widely to probe helical geometry in nucleic acid structures, nucleic acid-drug complexes, an

135 The nucleic acid structure of these genes was then compared

136 and label G-quadruplexes: these higher-order nucleic acid structures originate in the assembly of fou

137 e Accord" on definitions and nomenclature of nucleic acid structure parameters.

138 in the number of large, 3D, high-resolution nucleic acid structures, particularly of the 30S and 50S

139 G-quadruplexes (G4s) are noncanonical nucleic acid structures pivotal to cellular processes an

140 Unusual nucleic acid structures play vital roles as intermediate

141 Z-nucleic acid structures play vital roles in cellular pro

142 interrogate and compare up to 2688 parallel nucleic acid structure-protein interactions in vitro.

143 g gene expression through the targeting of a nucleic acid structure rather than sequence.

144 have evolved mechanisms of evasion, masking nucleic acid structures recognized by the host, sequeste

145 ctors that interact with and process dynamic nucleic acid structures remains limited.

146 ectural role in the stabilization of protein-nucleic acid structures required for strand synapsis.

147 reatment results in severe distortion of the nucleic acid structure, restriction of all hydroxyl dihe

148 been learned thanks to mass spectrometry on nucleic acid structures, self-assemblies (e.g., duplexes

149 Nucleic acid structure, stability, and reactivity are go

150 G-quadruplexes are nucleic acids structures stabilized by physiological con

151 lves the formation and resolution of unusual nucleic acid structures, such as RNA:DNA hybrids.

152 ique, publication-quality representations of nucleic-acid structures, such as 'block' images of bases

153 sitivity towards very local perturbations in nucleic acid structure suggests that 2'-amine acylation

154 ic mechanisms for forming knots and links in nucleic acid structures suggests that molecules involvin

155 An R-loop is a three-stranded nucleic acid structure that consists of a DNA:RNA hybrid

156 G-quadruplex (GQ) is a noncanonical nucleic acid structure that is formed by guanine rich se

157 G-quadruplex (G4) is a higher-order nucleic acid structure that is formed by guanine-rich se

158 R-loops are three-stranded nucleic acid structures that accumulate on chromatin in

159 R-loops are three-stranded nucleic acid structures that are abundant and widespread

160 G-quadruplexes are higher-order nucleic acid structures that can form in G-rich telomere

161 es) routinely encounter proteins and unusual nucleic acid structures that can impede their progress.

162 R loops are three-stranded nucleic acid structures that comprise nascent RNA hybrid

163 s showed that the cleavage sites were stable nucleic acid structures that contained specific arrangem

164 R-loops are dynamic, co-transcriptional nucleic acid structures that facilitate physiological pr

165 R-loops are three-stranded nucleic acid structures that form during transcription,

166 G-quadruplexes (G4s) are non-canonical nucleic acid structures that form in guanine (G)-rich ge

167 kew favors R-loops, a type of three stranded nucleic acid structures that form upon annealing of an R

168 R-loops are a class of non-canonical nucleic acid structures that typically form during trans

169 R-loops are abundant three-stranded nucleic-acid structures that form in cis during transcri

170 R-loops are ubiquitous, dynamic nucleic-acid structures that play fundamental roles in D

171 amined the contribution of G-quadruplex (G4) nucleic acid structures to AID targeting in vivo.

172 ch these enzymes couple the rearrangement of nucleic acid structures to the binding and hydrolysis of

173 fficial format for deposition of protein and nucleic acid structures to the protein data bank (PDB) d

174 t there is limited characterization of these nucleic acid structures under physiologically and diseas

175 ay junctions (HJs) are an important class of nucleic acid structure utilized in DNA break repair proc

176 To understand the effect of C on nucleic acid structure, we undertook a detailed crystall

177 he competition dialysis method, 13 different nucleic acid structures were dialyzed against a common l

178 e transcriptionally generated three-stranded nucleic acid structures where the mRNA hybridizes with t

179 The G-quadruplex (G4) is a non-canonical nucleic acid structure which regulates important cellula

180 e for characterizing transient low-populated nucleic acid structures, which we predict will be abunda

181 The focus is on nucleic acid structures with a bias toward RNA.

182 The biological function of Z-DNA and Z-RNA, nucleic acid structures with a left-handed double helix,

183 (CT) properties are compared between peptide nucleic acid structures with an aminoethylglycine backbo

184 R-loops are three-stranded nucleic acid structures with both physiological and path

185 G-quadruplexes (G4s) are four-stranded nucleic acid structures with closely spaced guanine base

186 DNA:RNA hybrids, nucleic acid structures with diverse physiological funct

187 R-loops are three-stranded nucleic acid structures with essential roles in many nuc