ライフサイエンスコーパス: nucleocytoplasmic

1 eventing histone deacetylation by increasing nucleocytoplasmic acetyl-CoA levels impairs Wnt3a-induce

2 he nuclear envelope (NE) and is required for nucleocytoplasmic actin transport and the concomitant re

3 indings provide a resource for proteome-wide nucleocytoplasmic alterations across neurodegeneration-a

4 rins (Kaps), that mediate the trafficking of nucleocytoplasmic cargoes while also generating a select

5 A critical role for linchpin residues in nucleocytoplasmic coagulation and other forms of free ra

6 of GAPDH was studied as an in vitro model of nucleocytoplasmic coagulation.

7 lfide-cross-linked state via the process of "nucleocytoplasmic coagulation." Here, free radical-induc

8 cooperation between the chloroplast and the nucleocytoplasmic compartment during plant growth and de

9 We detected an age-dependent loss of nucleocytoplasmic compartmentalization (NCC) in donor fi

10 Thus, nucleocytoplasmic compartmentalization of licensing fact

11 rochromatin prevents it from re-establishing nucleocytoplasmic compartmentalization.

12 or 3 (NXF3) as a transporter that alters the nucleocytoplasmic distribution of box C/D snoRNAs from t

13 By genetically manipulating the nucleocytoplasmic distribution of Cdc55, we showed that

14 nd reciprocally regulates protein levels and nucleocytoplasmic distribution of GI in Arabidopsis.

15 There was no change in the nucleocytoplasmic distribution of Snail1 using wild type

16 In line with its obligatory nucleocytoplasmic distribution, DNA binding was only obs

17 proteins of 20 key phylogenetically distinct nucleocytoplasmic DNA viruses (NCLDV).

18 egalovirus relies on elaborate mechanisms of nucleocytoplasmic egress of viral particles.

19 rupt RGS14 binding to Galphai1-GDP and XPO1, nucleocytoplasmic equilibrium, and capacity to inhibit l

20 ear pore complex (NPC), the sole gateway for nucleocytoplasmic exchange in eukaryotic cells, allows f

21 assembly that serves as the sole mediator of nucleocytoplasmic exchange in eukaryotic cells.

22 Our results document regulated nucleocytoplasmic exchange of C3G in response to physiol

23 model of transcriptional activation based on nucleocytoplasmic exchange properties of YAP.

24 nuclear pore complexes (NPCs) controls bulk nucleocytoplasmic exchange.

25 ponents of all eukaryotic cells that mediate nucleocytoplasmic exchange.

26 clear pore complexes (NPCs) are gateways for nucleocytoplasmic exchange.

27 ransport complexes responsible for selective nucleocytoplasmic exchange.

28 Nuclear pore complexes (NPCs) mediate nucleocytoplasmic exchange.

29 oplasm and a major platform that coordinates nucleocytoplasmic exchanges, gene expression, and genome

30 f the HIV Rev protein on the RRE promote the nucleocytoplasmic export of incompletely spliced mRNAs,

31 dependent phosphorylation site essential for nucleocytoplasmic export of LKB1(S) and consequent AMPK

32 Once considered unusual, nucleocytoplasmic glycosylation is now recognized as a c

33 ress in Schizosaccharomyces pombe, where the nucleocytoplasmic HMG protein Oxs1 acts cooperatively wi

34 In the classical nucleocytoplasmic import pathway, nuclear localization s

35 ntral role in macromolecular trafficking and nucleocytoplasmic information transfer, the nuclear pore

36 only in D5 but also in other viruses of the nucleocytoplasmic large DNA virus (NCLDV) clade.

37 frican swine fever virus (ASFV) is a complex nucleocytoplasmic large DNA virus (NCLDV) that causes a

38 Although the nucleocytoplasmic large DNA viruses (NCLDVs) are one of

39 Nucleocytoplasmic large DNA viruses (NCLDVs) are ubiquit

40 Nucleocytoplasmic large DNA viruses (NCLDVs) have recent

41 Our current knowledge about nucleocytoplasmic large DNA viruses (NCLDVs) is largely

42 Nucleocytoplasmic Large DNA Viruses that infect phytopla

43 ith the majority apparently belonging to the nucleocytoplasmic large DNA viruses.

44 arch on perinuclear factories induced by the nucleocytoplasmic large DNA viruses.

45 virus satellites that prey on giant viruses (nucleocytoplasmic large DNA viruses; NCLDVs), which are

46 ses have been discovered and assigned to the nucleocytoplasmic large dsDNA virus (NCLDV) clade.

47 and fractionation reveal that HopQ1 exhibits nucleocytoplasmic localization, while HopQ1 dephosphoryl

48 on 12 yield Esrp1 isoforms with differential nucleocytoplasmic localization.

49 The nucleocytoplasmic location of this protein supports a di

50 hip of the FG-Nups and provides a picture of nucleocytoplasmic mass exchange that allows a reconcilia

51 e propose a model of stepwise acquisition of nucleocytoplasmic mechanistic complexity and demonstrate

52 urons displayed increased levels of hnRNP A1 nucleocytoplasmic mislocalization and stress granule for

53 RM1/Exportin-1) receptor pathway, but retain nucleocytoplasmic mobility.

54 Nucleocytoplasmic molecular transport, however, is tight

55 tion to their main role in the regulation of nucleocytoplasmic molecule exchange, it has become evide

56 The MBT is triggered by a critical nucleocytoplasmic (N/C) ratio; however, the molecular ba

57 Conversely, reduced expression of both nucleocytoplasmic (ncOGT) and mitochondrial (mOGT) OGT i

58 Here we verify that TgSPY is the nucleocytoplasmic O-fucosyltransferase (OFT) by 1) compl

59 Ac transferase (OGT), is responsible for all nucleocytoplasmic O-GlcNAcylation.

60 machinery that is predicted to regulate the nucleocytoplasmic O-Man glycosylations.

61 taset allows unprecedented insights into the nucleocytoplasmic organisation of eukaryotic cells, into

62 it played a critical role in inhibiting the nucleocytoplasmic oscillations of the transcription fact

63 oocytes via microdissection and measured the nucleocytoplasmic partitioning of approximately 9,000 pr

64 Nucleocytoplasmic partitioning of core clock components

65 vel a potential role of SPA proteins in COP1 nucleocytoplasmic partitioning, we monitored the subcell

66 n modulate the GI/ZTL interaction as well as nucleocytoplasmic partitioning.

67 Here we show that nucleocytoplasmic posttranslational modification of prot

68 Nucleolin (NCL) is a nucleocytoplasmic protein involved in many biological pr

69 Ac transferase (OGT), O-GlcNAcase (OGA), and nucleocytoplasmic protein O-GlcNAcylation in the most ba

70 lar system to study gene transactivation and nucleocytoplasmic protein trafficking.

71 on of 4E-T(ransporter), an additional P-body nucleocytoplasmic protein, revealed that 4E-T colocalize

72 e O-GlcNAc posttranslational modification of nucleocytoplasmic proteins and proteolytic maturation of

73 However, the type of yeast O-Man nucleocytoplasmic proteins and the localization of ident

74 glycosylation is thought to be restricted to nucleocytoplasmic proteins of eukaryotes and is mediated

75 inked beta-N-acetylglucosamine (O-GlcNAc) on nucleocytoplasmic proteins serves as a nutrient sensor t

76 egulatory post-translational modification of nucleocytoplasmic proteins that has been implicated in m

77 post-translational signaling modification of nucleocytoplasmic proteins that is essential for embryon

78 s a common posttranslational modification of nucleocytoplasmic proteins with beta-N-acetylglucosamine

79 fication of specific Ser and Thr residues of nucleocytoplasmic proteins with O-GlcNAc, catalyzed by O

80 ible for catalyzing removal of O-GlcNAc from nucleocytoplasmic proteins.

81 onsive post-translational O-GlcNAcylation of nucleocytoplasmic proteins.

82 on and off serine and threonine residues of nucleocytoplasmic proteins.

83 residues to serine and threonine residues of nucleocytoplasmic proteins.

84 rring on the serine or threonine residues of nucleocytoplasmic proteins.

85 However, not all P-body components are nucleocytoplasmic proteins; rck/p54, Dcp1a, Edc3, Ge-1,

86 r scale and simultaneously maintain a normal nucleocytoplasmic ratio across a syncytium up to the cen

87 features of bacterial cells, implicating the nucleocytoplasmic ratio and cell size as determinants of

88 Twine protein destruction was timed by the nucleocytoplasmic ratio and depended on the activation o

89 As in eukaryotes, the nucleocytoplasmic ratio in bacteria varies greatly among

90 ow that this destruction is triggered by the nucleocytoplasmic ratio-dependent onset of zygotic trans

91 Bacteria with different nucleocytoplasmic ratios have a cytoplasm with different

92 This spectrum of nucleocytoplasmic ratios is independent of genome size,

93 alian cells by picornaviruses results in the nucleocytoplasmic redistribution of certain host cell pr

94 rus 2A proteinase is sufficient to cause the nucleocytoplasmic redistribution of SRp20.

95 The Mollivirus nucleocytoplasmic replication cycle was analyzed using a

96 HuR is a ubiquitous nucleocytoplasmic RNA-binding protein that exerts pleiot

97 thelial tubules are forming and branching, a nucleocytoplasmic shift in Yap localization marks the bo

98 ults also imply that p012 could constitute a nucleocytoplasmic shuttle protein, a feature that could

99 titative assay, which detects differences in nucleocytoplasmic shuttling among seven canonical SR pro

100 s, which suggests that aging causes impaired nucleocytoplasmic shuttling and activation of SIRT1 duri

101 Whereas human SRY requires nucleocytoplasmic shuttling and coupled phosphorylation,

102 Due to its rapid nucleocytoplasmic shuttling and high expression level in

103 SUMO activation enzyme (SAE) underwent rapid nucleocytoplasmic shuttling and its nuclear accumulation

104 d the D226 mutation impair HuR's PARylation, nucleocytoplasmic shuttling and mRNA binding.

105 e have shown that C9orf72 may be involved in nucleocytoplasmic shuttling and this may have relevance

106 WWP2 mediates the TGFbeta1-induced nucleocytoplasmic shuttling and transcriptional activity

107 method provides a powerful tool for studying nucleocytoplasmic shuttling at the nanometer scale under

108 aling, which involves the regulation of Hxk2 nucleocytoplasmic shuttling by phosphorylation-dephospho

109 ermore, we have identified an NES-containing nucleocytoplasmic shuttling domain (aa 19 to 40) of p17

110 the variants exhibited selective defects in nucleocytoplasmic shuttling due to impaired nuclear impo

111 sensors that convert kinase activity into a nucleocytoplasmic shuttling equilibrium for visualizing

112 r technology converts phosphorylation into a nucleocytoplasmic shuttling event that can be measured b

113 CaMKI enzyme, which exhibits T(c)-dependent nucleocytoplasmic shuttling in AFD.

114 a GATA transcription factor, exhibits rapid nucleocytoplasmic shuttling in response to cAMP waves.

115 elopment, the specific roles for Yap and its nucleocytoplasmic shuttling in the developing airway and

116 Remarkably, we found that Yap nucleocytoplasmic shuttling is largely dispensable in ep

117 hREBP activity is regulated in large part by nucleocytoplasmic shuttling of ChREBP protein via intera

118 Nucleocytoplasmic shuttling of class IIa of histone deac

119 inine methyltransferase 1 (PRMT1), regulates nucleocytoplasmic shuttling of FUS.

120 Furthermore, we observe cyclical nucleocytoplasmic shuttling of HDAC5 in mouse fibroblast

121 d beta-AR mediated signaling at the level of nucleocytoplasmic shuttling of HDAC5.

122 hat Sik3 reduction interferes with circadian nucleocytoplasmic shuttling of Histone deacetylase 4 (HD

123 Nucleocytoplasmic shuttling of Hxk2 induced by glucose l

124 c7-Reg1 as novel regulatory partners for the nucleocytoplasmic shuttling of Hxk2.

125 f hnRNP A1 or lamin A/C led to inhibition of nucleocytoplasmic shuttling of p17 and reduced virus yie

126 To date the mechanisms underlying nucleocytoplasmic shuttling of p17 remain largely unknow

127 rtheless, whether cellular proteins modulate nucleocytoplasmic shuttling of p17 remains unknown.

128 as carrier and mediator proteins to modulate nucleocytoplasmic shuttling of p17.

129 dulate both p17 and hnRNP A1 interaction and nucleocytoplasmic shuttling of p17.

130 ) A1 serves as a carrier protein to modulate nucleocytoplasmic shuttling of p17.

131 is critical for binding to hnRNP A1 and for nucleocytoplasmic shuttling of p17.

132 Thus regulated nucleocytoplasmic shuttling of RLIM/Rnf12 coordinates ce

133 olled through reversible phosphorylation and nucleocytoplasmic shuttling of Smad1, Smad5, and Smad8 (

134 Our results demonstrate that nucleocytoplasmic shuttling of SRY is necessary for robu

135 an sex reversal due to subtle defects in the nucleocytoplasmic shuttling of SRY suggests that its tra

136 ins, which are involved in the regulation of nucleocytoplasmic shuttling of target proteins, restrict

137 hts into how hnRNP A1 and lamin A/C modulate nucleocytoplasmic shuttling of the ARV p17 protein.

138 sights into hnRNP A1 and lamin A/C-modulated nucleocytoplasmic shuttling of the ARV p17 protein.IMPOR

139 We employed the nucleocytoplasmic shuttling of the transcriptional repre

140 ity levels can be also used as predictors of nucleocytoplasmic shuttling of transcription factors and

141 instead show dramatically elevated rates of nucleocytoplasmic shuttling of YAP, suggesting an escape

142 We reveal that TPL-2 is a nucleocytoplasmic shuttling protein and identify the nuc

143 ether, these findings suggest that XIW1 is a nucleocytoplasmic shuttling protein and plays a positive

144 uence YXXXXLPhi, shared with eIF4G, and is a nucleocytoplasmic shuttling protein found enriched in P-

145 In human cells, DcpS is a nucleocytoplasmic shuttling protein that activates miRNA

146 ous nuclear ribonucleoprotein (hnRNP) K is a nucleocytoplasmic shuttling protein that is a key player

147 Nef-associated factor 1 (Naf1) is a host nucleocytoplasmic shuttling protein that regulates multi

148 Gle1 is a nucleocytoplasmic shuttling protein with well-documented

149 We previously demonstrated that ATF2 is a nucleocytoplasmic shuttling protein, and it contains two

150 Nucleophosmin (NPM1) is a nucleocytoplasmic shuttling protein, mainly localized at

151 Nucleophosmin (NPM1) is a nucleocytoplasmic shuttling protein, mainly localized at

152 RGS14 also is a nucleocytoplasmic shuttling protein, suggesting that bal

153 The mechanisms underlying betacatenin nucleocytoplasmic shuttling remain incompletely defined.

154 rylation, pancreatic and duodenal homeobox 1 nucleocytoplasmic shuttling, and transcription of insuli

155 his dynamics is determined by the balance of nucleocytoplasmic shuttling, formin- and redox-dependent

156 e process involving Smad phosphorylation and nucleocytoplasmic shuttling, regulated by rigidity-depen

157 SmgGDS undergoes nucleocytoplasmic shuttling, suggesting that it has both

158 ls treated with a peptide that disrupts Gle1 nucleocytoplasmic shuttling, we detected nuclear accumul

159 og1, revealed both coordinated and decoupled nucleocytoplasmic shuttling.

160 interacts with nucleoporins to promote Smad2 nucleocytoplasmic shuttling.

161 259 and 498, whose phosphorylations control nucleocytoplasmic shuttling.

162 reen to identify pathways controlling TDP-43 nucleocytoplasmic shuttling.

163 2+) channel, as a strong modulator of TDP-43 nucleocytoplasmic shuttling.

164 signal and experimental data confirmed BEX3 nucleocytoplasmic shuttling.

165 ver, the trypanosome NPC has almost complete nucleocytoplasmic symmetry, in contrast to the opisthoko

166 we present evidence that indicates that Hxk2 nucleocytoplasmic traffic is regulated by phosphorylatio

167 The massive nuclear pore complex mediates nucleocytoplasmic traffic ranging from a single histone

168 myocarditis virus (EMCV) shuts off host cell nucleocytoplasmic trafficking (NCT) by inducing hyperpho

169 wn of certain nucleoporins and components of nucleocytoplasmic trafficking alter integration site pre

170 partners to bring about inhibition of active nucleocytoplasmic trafficking and cap-dependent translat

171 w that RASSF1A is a novel regulator of actin nucleocytoplasmic trafficking and is required for the ac

172 otent antihost inhibition of active cellular nucleocytoplasmic trafficking by triggering aberrant hyp

173 In addition, our results indicate that nucleocytoplasmic trafficking can tolerate both partial

174 tracellular protein redistribution, impaired nucleocytoplasmic trafficking has emerged as a mechanism

175 Nuclear pore complex (NPC)-mediated nucleocytoplasmic trafficking is essential for key cellu

176 nducible kinase 2 (SIK2) and SIK3 to promote nucleocytoplasmic trafficking of class IIa HDACs.

177 pore complex (NPC) is disintegrated and the nucleocytoplasmic trafficking of host mRNAs and host pro

178 e the nuclear envelope (NE) and regulate the nucleocytoplasmic trafficking of macromolecules.

179 ithin the nuclear envelope, NPCs mediate the nucleocytoplasmic trafficking of numerous cellular compo

180 rowth and differentiation by controlling the nucleocytoplasmic trafficking of proteins and RNAs, some

181 are important for cellular functions beyond nucleocytoplasmic trafficking, including genome organiza

182 rotein homeostasis, with specific defects in nucleocytoplasmic trafficking, the induction of stress a

183 suggesting the existence of myosin XI-driven nucleocytoplasmic trafficking.

184 rmed nucleoporins (Nups), mediates selective nucleocytoplasmic trafficking.

185 FAK complexes, depending on their respective nucleocytoplasmic trafficking.

186 ably altered in genetic mutants that disrupt nucleocytoplasmic trafficking.

187 tant to building a complete understanding of nucleocytoplasmic trafficking.

188 However, nucleocytoplasmic translocation of core clock proteins,

189 2) phosphorylation correlated with transient nucleocytoplasmic translocation of CREB.

190 ef-1 activated MAPK signaling, which induced nucleocytoplasmic translocation of FOXO1 and PDX1 and le

191 pendent phosphorylation of Ser-399 triggered nucleocytoplasmic translocation of LKB1(S) in response t

192 Here we show that this is triggered by nucleocytoplasmic translocation of the transcription fac

193 rtial sequestration of factors essential for nucleocytoplasmic transport (Gle1 and RanGAP1), and intr

194 Disrupted nucleocytoplasmic transport (NCT) has been implicated in

195 Although defects in nucleocytoplasmic transport (NCT) may be central to the

196 This necessitates nucleocytoplasmic transport (NCT) to bypass nuclear pore

197 was originally identified as a regulator of nucleocytoplasmic transport [1] and subsequently found t

198 is sufficient to decrease DPR levels, rescue nucleocytoplasmic transport abnormalities, and improve s

199 studies offered clues that mHTT may disrupt nucleocytoplasmic transport and a mutation of an NUP can

200 nisms that remain poorly defined, defects in nucleocytoplasmic transport and accumulations of specifi

201 entify polyglutamine-dependent inhibition of nucleocytoplasmic transport and alteration of nuclear in

202 nuclear pore complex (NPC) has dual roles in nucleocytoplasmic transport and chromatin organization.

203 uclear pore complex (NPC) is responsible for nucleocytoplasmic transport and constitutes a hub for co

204 oughout the cell cycle, including interphase nucleocytoplasmic transport and mitotic spindle assembly

205 c nuclear permeability barrier and selective nucleocytoplasmic transport are maintained by nuclear po

206 virus (RSV) Gag protein undergoes transient nucleocytoplasmic transport as an intrinsic step in viru

207 ycine (FG) repeats play an important role in nucleocytoplasmic transport as they bind to transport re

208 Here we demonstrate that nucleocytoplasmic transport at the membrane domain surro

209 position of NE-localized proteins along the nucleocytoplasmic transport axis.

210 The RanGTPase acts as a master regulator of nucleocytoplasmic transport by controlling assembly and

211 We suggest that defects in the nucleocytoplasmic transport components may be a general

212 Defective nucleocytoplasmic transport contributes to C9-ALS/FTD, b

213 tain this conformation throughout the entire nucleocytoplasmic transport cycle.

214 n (RanGAP) at the nuclear pore, resulting in nucleocytoplasmic transport deficit and accumulation of

215 nt signalling pathways rely on bidirectional nucleocytoplasmic transport events through the nuclear p

216 s) are key cellular transporter that control nucleocytoplasmic transport in eukaryotic cells, but its

217 cts in the nuclear pore complex and impaired nucleocytoplasmic transport in Huntington's disease (HD)

218 Therefore, we evaluated the NPC and nucleocytoplasmic transport in multiple models of HD, in

219 s provide evidence for an important role for nucleocytoplasmic transport in the pathogenic mechanism

220 Dysfunction in nucleocytoplasmic transport is also an emerging theme in

221 permeability, selectivity, and the speed of nucleocytoplasmic transport is an assembly of natively u

222 In animal models of HD, nucleocytoplasmic transport is disrupted and its restora

223 Nucleocytoplasmic transport is facilitated by nuclear po

224 Disruption of nucleocytoplasmic transport is increasingly implicated i

225 Nucleocytoplasmic transport is mediated by nuclear pore

226 Nucleocytoplasmic transport is mediated by nuclear pore

227 Nucleocytoplasmic transport is mediated by the interacti

228 Nucleocytoplasmic transport is sustained by karyopherins

229 Nucleocytoplasmic transport is tightly regulated by the

230 asm, it may mediate a connection between the nucleocytoplasmic transport machinery and the endosomal

231 concomitantly can interact with the soluble nucleocytoplasmic transport machinery.

232 exportins represent an essential part of the nucleocytoplasmic transport machinery.

233 rovides several binding sites for the mobile nucleocytoplasmic transport machinery.

234 rovides a multitude of binding sites for the nucleocytoplasmic transport machinery.

235 the NPC, taking a central role in the vital nucleocytoplasmic transport mechanism.

236 d23 is localized in the cytosol in rna1-1, a nucleocytoplasmic transport mutant, and it forms reduced

237 nslation; however, the mechanism(s) by which nucleocytoplasmic transport occurs and how Dbp5 specific

238 Retroviral replication requires the nucleocytoplasmic transport of both spliced and unsplice

239 role that can be considered dependent on the nucleocytoplasmic transport of macromolecules (i.e. is t

240 The nuclear pore complex mediates nucleocytoplasmic transport of macromolecules in eukaryo

241 In eukaryotes, the nucleocytoplasmic transport of macromolecules is mainly

242 The NPC regulates nucleocytoplasmic transport of macromolecules, utilizing

243 of the nuclear-pore complex, which regulates nucleocytoplasmic transport of macromolecules.

244 enetic information is regulated by selective nucleocytoplasmic transport of messenger RNA:protein com

245 Regulated nucleocytoplasmic transport of proteins is central to ce

246 naling in mammalian cells, and regulation of nucleocytoplasmic transport of RBP-J may contribute to f

247 inson-Gilford progeria syndrome inhibits the nucleocytoplasmic transport of several factors with key

248 tions with components of the endocytosis and nucleocytoplasmic transport pathways, regulated by p300-

249 t factors underlie the efficiency of certain nucleocytoplasmic transport pathways.

250 Here we analyzed the nucleocytoplasmic transport properties of both Gag prote

251 o system, transport disruption is not due to nucleocytoplasmic transport protein sequestration, nor b

252 show that importin beta, a well established nucleocytoplasmic transport protein, interacts with comp

253 irst time revealed a novel role that MOG1, a nucleocytoplasmic transport protein, plays in cardiac ph

254 estration and impairment of nuclear HR23 and nucleocytoplasmic transport proteins is an outcome of, a

255 s will continue to be applied to outstanding nucleocytoplasmic transport questions, and that the appr

256 Continuous cycles of nucleocytoplasmic transport require disassembly of trans

257 answer by other means, yet the complexity of nucleocytoplasmic transport requires that interpretation

258 Rather, disruptions in Dbp5 nucleocytoplasmic transport result in tRNA export defect

259 The nuclear pore complex gates nucleocytoplasmic transport through a massive, eight-fol

260 The nuclear pore complex (NPC) mediates nucleocytoplasmic transport through the nuclear envelope

261 f G4C2 repeat expansion is the compromise of nucleocytoplasmic transport through the nuclear pore, re

262 ights into how these nucleoporins coordinate nucleocytoplasmic transport to mount a robust immune res

263 Nuclear transport receptors (NTRs) mediate nucleocytoplasmic transport via their affinity for unstr

264 easomal degradation and proteins involved in nucleocytoplasmic transport were sequestered by poly(GA)

265 racts with RAN and normally functions in the nucleocytoplasmic transport while exerts its pathogenic

266 esponse to changes in membrane synthesis and nucleocytoplasmic transport, altering nuclear size.

267 romised nuclear envelope integrity, impaired nucleocytoplasmic transport, and accumulation of DNA dou

268 ct role of the disorder within FG repeats in nucleocytoplasmic transport, and resolves the apparent c

269 he nuclear pore complexes (NPCs) that enable nucleocytoplasmic transport, and the spindle pole bodies

270 and Nup107, thereby provoking inhibition of nucleocytoplasmic transport, clearance of nuclear TDP-43

271 -FTD spectrum disorder, including autophagy, nucleocytoplasmic transport, DNA damage repair, pre-mRNA

272 gradient of RanGTP on chromatin that directs nucleocytoplasmic transport, mitotic spindle assembly an

273 y of GTPases, is best known for its roles in nucleocytoplasmic transport, mitotic spindle fiber assem

274 The NUP107 complex is important for nucleocytoplasmic transport, nuclear envelope assembly,

275 with recent reports showing that DPRs affect nucleocytoplasmic transport, our results point to an imp

276 g karyopherins and effectors of Ran-mediated nucleocytoplasmic transport, providing insight into pote

277 included 1) mRNAs within the nucleolus when nucleocytoplasmic transport, rRNA biogenesis, or RNA pro

278 P) is important to Ran signaling involved in nucleocytoplasmic transport, spindle organization, and p

279 dipeptide repeats produced by C9-HRE disrupt nucleocytoplasmic transport, the proteins that become re

280 Nucleocytoplasmic transport, the trafficking of macromol

281 causal role of poly-GR or poly-PR on active nucleocytoplasmic transport, we measured nuclear import

282 TG (RAN) translation proteins also disrupted nucleocytoplasmic transport.

283 ficking and transport vesicle formation, and nucleocytoplasmic transport.

284 hting the importance of the shape effects in nucleocytoplasmic transport.

285 ) are 110-megadalton assemblies that mediate nucleocytoplasmic transport.

286 lex (NPC) filaments and is a docking site in nucleocytoplasmic transport.

287 nstitutes the sole gateway for bidirectional nucleocytoplasmic transport.

288 oncentration in the nucleus is important for nucleocytoplasmic transport.

289 Nups in the nuclear pore, and mechanisms of nucleocytoplasmic transport.

290 ptors (Karyopherins (Kaps)) that orchestrate nucleocytoplasmic transport.

291 mbers (karyopherins) mediate the majority of nucleocytoplasmic transport.

292 t, consistent with its essential function in nucleocytoplasmic transport.

293 ycine-rich nucleoporins (FG-Nups) to control nucleocytoplasmic transport.

294 ility of Cic by controlling the rates of its nucleocytoplasmic transport.

295 sport, DNA repair, chromatin remodeling, and nucleocytoplasmic transport.

296 excitotoxicity, disease-associated RBPs, and nucleocytoplasmic transport.

297 oly-GR and poly-PR, has been associated with nucleocytoplasmic transport.

298 GR and poly-PR do not directly impede active nucleocytoplasmic transport.

299 ation coincides with striking alterations in nucleocytoplasmic transport.

300 zation and aggregation of NUPs and defective nucleocytoplasmic transport.