ライフサイエンスコーパス: nucleolar

1 ce prioritized protein-coding gene G Protein Nucleolar 3 (GNL3) as a BD risk gene, with integrative a

2 s into rRNA structural rearrangements during nucleolar 60S assembly.

3 Nucleolar-accumulated CBX proteins are immobile, but rem

4 er, it reveals that rRNA accumulation and/or nucleolar activity unexpectedly regulate dsDNA-sensing t

5 36) has been implicated in the regulation of nucleolar activity.

6 ences supernumerary rDNA units and regulates nucleolar activity.

7 exclusively cytoplasmic, the CPEB4 LCD forms nucleolar aggregates and CPEB4 LCD-expressing animals ha

8 Thus, anti-nucleolar and pro-apoptotic effects of protein C are fla

9 The nucleolar and spindle-associated protein NUSAP1 is a mic

10 by global chromosome architecture, provides nucleolar and/or nuclear peripheral anchoring points con

11 argeting and meiosis and impacts nuclear and nucleolar architecture when deleted or overexpressed.

12 synthesis and large-scale reorganization of nucleolar architecture, but the signaling events that re

13 Gle1 targeting and modulation of nuclear and nucleolar architecture.

14 promotes the localization of specific loci (nucleolar-associated domains [NADs]) and proteins to the

15 ated function of TDP-43 in the processing of nucleolar-associated RNA.

16 s of the RAG1 N-terminal region that control nucleolar association and egress.

17 f all NORs during interphase, and found that nucleolar association of acrocentric p-arms can occur in

18 en Ki-67, whose depletion also decreases the nucleolar association of NADs.

19 We determined the nucleolar association status of all NORs during interpha

20 ces elsewhere on these chromosome arms drive nucleolar association.

21 ll 10 acrocentric chromosomes is dictated by nucleolar association.

22 h serotype-specific differential patterns of nucleolar association; AAPs and assembled capsids do not

23 Furthermore, these nucleolar associations are buffered against interindivid

24 The nucleolar associations of both classes of NADs were conf

25 The extent of nucleolar autoantigen degradation upon C1 treatment was

26 cells, nucleoli were targeted by C1q and two nucleolar autoantigens were degraded by C1r/C1s protease

27 trate that CMV pUL31 functions in regulating nucleolar biology and contributes to the reorganization

28 UL31 is necessary and sufficient to regulate nucleolar biology involving the reorganization of nucleo

29 tion of nucleoli during infection.IMPORTANCE Nucleolar biology is important during CMV infection with

30 er, the extent of CMV-mediated regulation of nucleolar biology is not well established.

31 ging that is easily ascertained, grounded on nucleolar biology, and could serve as a universal marker

32 741-746) demonstrate that "orphan" nucleolar box C/D snoRNA SNORD97 and CB box C/D scaRNA S

33 ar clusters providing a spatial framework of nucleolar chromatin organization at unprecedented detail

34 is accompanied by release of the repressive nucleolar chromatin remodeling complex (NoRC) from rDNA,

35 ion of active rDNA chromatin units and their nucleolar clusters providing a spatial framework of nucl

36 CIZ1-DHX9 nucleolar colocalisation is dependent upon RNA polymeras

37 ve rDNA loci spatially colocated in the same nucleolar compartment.

38 at explains the differential partitioning of nucleolar components in budding yeast mitosis.

39 ired for phase separation of NPM1 with other nucleolar components in vitro and for localization withi

40 ion of TOP2-DNA covalent complexes nor their nucleolar concentration are due to TOP2 hyperubiquitinat

41 ar distribution, PR-619 treatment results in nucleolar concentration of TOP2A and TOP2B.

42 of alpha-satellite transcripts by centromere-nucleolar contacts provides a mechanism to modulate cent

43 ), Piwi-interacting (piRNAs), small nuclear, nucleolar, cytoplasmic (sn-, sno-, scRNAs, respectively)

44 Elevated levels of PARP-1 and nucleolar DDX21 are associated with cancer-related outco

45 which associates with chromosomes only after nucleolar disassembly later in prophase.

46 ic rDNA induced by the BBDS mutations direct nucleolar disorganization, alter ribosome biogenesis, an

47 t a putative link exists between NSs-induced nucleolar disruption and its inhibitory function on cell

48 m redistribution, evocative of virus-induced nucleolar disruption.

49 Nucleolar dominance (ND) consists of the reversible sile

50 silencing of 35S rRNA genes (rDNA), known as nucleolar dominance (ND), is common in interspecific hyb

51 leoplasmic deubiquitinase (DUB) USP1 and the nucleolar DUB USP36.

52 oplets, many ramifications of LLPS including nucleolar dynamics and interactions with the surrounding

53 signing new therapeutic strategies to target nucleolar dysfunction.

54 The anti-nucleolar effects were most pronounced in postmitotic ne

55 luded from the nucleolus, in contrast to the nucleolar enrichment of assembled AAV2 capsids; and, sur

56 significant increase in ribosome biogenesis, nucleolar expansion and cell growth in a manner dependen

57 in A expression are each sufficient to drive nucleolar expansion.

58 The nucleolar factor, digestive organ expansion factor (DEF)

59 of Caenorhabditis elegans in the absence of nucleolar fragmentation.

60 a prerequisite for the occurance of aberrant nucleolar function and increased anabolic processes in g

61 We discuss how nucleolar function is linked to its organization as a mu

62 Yet, the precise link between NuMA and nucleolar function remains undetermined.

63 o our knowledge, this is the first report of nucleolar functions for NSs within the Bunyaviridae fami

64 we report the newly identified small GTPase, Nucleolar GTP-binding protein 1 (NOG1), functions for pl

65 RNA and tRNA synthesis, stabilization of the nucleolar GTP-binding protein nucleostemin, and enlarged

66 (GNL1) is an evolutionary conserved putative nucleolar GTPase belonging to the HSR1_MMR1 subfamily of

67 sheds light on a sophisticated mechanism of nucleolar homeostasis surveillance during stress.

68 SNHG7, a member of the small nucleolar host gene family, is a highly-expressed lncRNA

69 uman NF-kappaB repressing factor (NKRF) as a nucleolar HSP essential for nucleolus homeostasis and ce

70 strong cytological and molecular phenotypes: nucleolar hypertrophy and disorganization, overaccumulat

71 with elevation of rRNA and tRNA levels, and nucleolar hypertrophy.

72 In the presence of DSBs, TLC1 RNA remains nucleolar in most G2/M cells but accumulates in the nucl

73 reduced ribosome content without disrupting nucleolar integrity, cell survival, and signaling respon

74 Instead, our work implicates centromere-nucleolar interactions as repressing alpha-satellite exp

75 II and facilitates their maturation, while a nucleolar isoform has been implicated in rRNA biogenesis

76 , we found that Nop4 is a hub protein in the nucleolar large subunit (LSU) processome interactome.

77 icking, controlling 5'-to-3' exoribonuclease nucleolar levels and regulating rRNA processing.

78 ontained a significantly increased number of nucleolar-like bodies compared with normal zygotes.

79 H3K9me3-rich rings around the nucleolar-like bodies retained 5mC in the maternal mutan

80 his study reveals that Liat1 participates in nucleolar LLPS regulated by Jmjd6.

81 Mutation to disrupt dimerization prevents nucleolar localisation of PiSFI3 and attenuates both its

82 Both abrogation of BCCIP nucleolar localization and impaired BCCIP-eIF6 interacti

83 We propose that one mechanism of nucleolar localization involves phase separation of prot

84 Mutation of the RAG1 nucleolar localization motif boosts recombination while

85 within p150N, which is also required for the nucleolar localization of NADs and Ki-67 during interpha

86 he RNAi-mediated depletion of UBF diminishes nucleolar localization of SmgGDS and promotes proteasome

87 ata provide a mechanism for the assembly and nucleolar localization of the human ITS2 pre-rRNA endonu

88 Furthermore, we uncover a Nol9-encoded nucleolar localization sequence that is responsible for

89 Here, we show that NSs contains a nucleolar localization signal (NoLS) and induces disorga

90 ly appears to target the nucleolus through a nucleolar localization signal (NoLS) localized between r

91 antly, these R-motifs are found in canonical nucleolar localization signals.

92 Mammalian WDR12 displays prominent nucleolar localization that is dependent upon active rib

93 for a multifunctional protein with prominent nucleolar localization that shuttles between nucleus and

94 of the ADP-ribosylation sites reduces DDX21 nucleolar localization, rDNA transcription, ribosome bio

95 f 22 C-terminal residues of ZIKV-C prevented nucleolar localization, ribosomal stress and apoptosis.

96 ctivity on gene expression is related to its nucleolar localization.

97 lowed identification of a motif required for nucleolar localization.

98 The fraction of nucleolar-localized centromeres inversely correlates wit

99 . brucei's vtRNA is highly enriched in a non-nucleolar locus in the cell nucleus implicated in SL RNP

100 nucleoli, reduced association of RAG1 with a nucleolar marker, and increased V(D)J recombination acti

101 NSs colocalizes with nucleolar markers such as B23 (nucleophosmin) and fibril

102 omosomal ribosomal DNA circles, and abnormal nucleolar material - are sequestered away from chromosom

103 These changes in nucleolar material properties manifest in specific alter

104 ctively tuned by the cell through modulating nucleolar material properties, which suggests the potent

105 n toxicity was accompanied by the absence of nucleolar mislocalization of paraspeckle protein P54nrb,

106 Nucleolar morphology is controlled by chromatin structur

107 depletion of SmgGDS in cancer cells disrupts nucleolar morphology, signifying nucleolar stress.

108 c noncoding RNAs (sincRNAs) that can disrupt nucleolar organization and rRNA expression.

109 both proteins altered pUL31 localization and nucleolar organization.

110 gest structures in human nuclei, form around nucleolar organizer regions (NORs) comprising ribosomal

111 d Gr359 occurred in both the centromeres and nucleolar organizer regions (NORs) in D- and AD-genome s

112 We reveal two types of nucleolar pair dynamics: an unexpected correlated motion

113 of NPM1, altering its phase separation with nucleolar partners to the extreme of forming large, solu

114 In contrast, the nucleolar pattern of B23 was unchanged upon infection wi

115 pe I NADs associate frequently with both the nucleolar periphery and the nuclear lamina, and generall

116 Furthermore, the nucleolar phosphoprotein nucleophosmin (NPM1) acts as a

117 NPM1 (nucleophosmin 1) is a nucleolar phosphoprotein that regulates many cellular pr

118 ed Ser/Thr residues at the C-terminus of the nucleolar phosphoprotein Treacle.

119 rowth, demonstrating that the NPM1-dependent nucleolar PIDDosome is a key initiator of the caspase-2

120 RAIDD dependent but PIDD independent, and a nucleolar platform that requires both PIDD and RAIDD.

121 ween the major RNA polymerases, and identify nucleolar Pol II as a major factor in protein synthesis

122 We reveal a nucleolar Pol-II-dependent mechanism that drives ribosom

123 eolus to the nucleoplasm during heat stress; nucleolar pools are replenished during recovery upon HSF

124 lectron microscopy structure of the earliest nucleolar pre-ribosomal assembly - the 5' external trans

125 Midasin's role in assembling Nsa1 particles, nucleolar precursors of the 60S subunit.

126 Moreover, in the latter system, nucleolar presence of ZIKV capsid protein (ZIKV-C) was a

127 67 interactors included proteins involved in nucleolar processes and chromatin regulators.

128 of only certain Pt(II) compounds to activate nucleolar processes.

129 Nucleolar prominence is a histologic hallmark of CaP; ho

130 Here, we report that deletion of Nol3 (Nucleolar protein 3) in mice leads to an MPN resembling

131 lyze expression and localization of BOP1 and nucleolar protein 56 in human tissue samples from variou

132 f mice with CKD have increased expression of nucleolar protein 66 (NO66), as do muscle biopsy specime

133 aryotic-like domains, here we identify NopA (nucleolar protein A), which displays four regulator of c

134 The nucleolar protein block of proliferation 1 (BOP1) is ass

135 tion in an RNA recognition motif of RBM28, a nucleolar protein conserved to yeast (Nop4).

136 r with photobleaching experiments to measure nucleolar protein dynamics in anaphase, consolidate a mo

137 pitation experiments revealed that the major nucleolar protein fibrillarin is coprecipitated in the P

138 ression of rRNA, ribosomal proteins, and the nucleolar protein fibrillarin, dependent on NCL-1.

139 Nucleolar protein interacting with the FHA domain of pKi

140 We found that nucleolin, a nucleolar protein involved in ribosomal maturation, boun

141 Hog1 phosphorylates the nucleolar protein Net1, altering its affinity for the ph

142 ligomerization domain of the multifunctional nucleolar protein nucleophosmin (Npm-N) are central to i

143 e liquid-like nucleoli, co-localize with the nucleolar protein nucleophosmin (NPM1), and alter the ph

144 We report that Nucleolin (Ncl), a nucleolar protein that regulates rRNA synthesis and ribo

145 Furthermore, we show that FGF13 1A is a nucleolar protein that represses ribosomal RNA transcrip

146 y is important during CMV infection with the nucleolar protein, with nucleolin playing a role in main

147 LTSCR2) and yeast (Saccharomyces cerevisiae) Nucleolar protein53 (Nop53) are orthologous proteins wit

148 lacked significant autoproteolysis, but many nucleolar proteins and autoantigens were degraded by C1

149 also interacts with a set of EBP1-associated nucleolar proteins as well as factors that function in p

150 quantitative dynamics by which six different nucleolar proteins assemble into the nucleoli of Drosoph

151 included members of the cohesin complex and nucleolar proteins associated with rDNA biology.

152 ion, and functional significance of specific nucleolar proteins have not been investigated thoroughly

153 evealed an association of RAG1 with numerous nucleolar proteins in a manner dependent on amino acids

154 er investigation into the functional role of nucleolar proteins in advanced CaP.

155 degron system can be used to rapidly deplete nucleolar proteins in mammalian cells, that PAF53 is nec

156 smic concentration and distribution of these nucleolar proteins in the wild-type embryos is consisten

157 functional clusters: ribosomal subunits and nucleolar proteins including the DEAD box helicases, DHX

158 factors RBM8A, SRSF9, and PSF as well as the nucleolar proteins NPM1 and PHF6, and recombinant GSK-3b

159 protease activation and the cleavage of many nucleolar proteins or autoantigens.

160 ntinuclear autoimmunity by broadly degrading nucleolar proteins or autoantigens.

161 t with their in vivo immiscibility, purified nucleolar proteins phase separate into droplets containi

162 In the absence of rDNA, the nucleolar proteins studied are able to form high-concent

163 oantigens were degraded by C1 proteases; >20 nucleolar proteins were identified as C1 cleavable.

164 After C1 treatment, cleaved nucleolar proteins were identified by proteomic two-dime

165 gation has identified NuMA among hundreds of nucleolar proteins.

166 olar biology involving the reorganization of nucleolar proteins.

167 that MLN4924 changes the composition of the nucleolar proteome but does not inhibit RNA Pol I transc

168 It also indicates that targeting the nucleolar proteome without affecting nucleolar transcrip

169 th camptothecin which transiently stabilized nucleolar R-loops recruited RNase H1 to the nucleoli.

170 s, where it interacts with EBP2 and leads to nucleolar re-localization of c-Myc.

171 progression at the G1/S transition and that nucleolar recruitment is integral to their mechanism of

172 biogenesis is also coincident with increased nucleolar recruitment of Rictor, an essential component

173 This nucleolar remodeling appears to be mediated through the

174 itute the central scaffolding protein of the nucleolar remodeling complex (NoRC) that regulates the e

175 d RNA, which prevents the recruitment of the nucleolar remodeling complex to the ribosomal DNA promot

176 dition to drastic accumulation of sumoylated nucleolar RENT and inner kinetochore complexes.

177 Here we show that the nucleolar response to rDNA breaks is dependent on both A

178 ) guide pseudouridylation as part of a small nucleolar ribonucleoprotein complex (snoRNP).

179 lence, including SpoU methylase and U3 small nucleolar ribonucleoprotein IMP3.

180 d in transcriptional regulation and in small nucleolar ribonucleoprotein particle assembly and thus p

181 Small nucleolar ribonucleoproteins (snoRNPs) guide the folding

182 complexes, such as RNA polymerase II, small nucleolar ribonucleoproteins and mammalian target of rap

183 Box C/D small (nucleolar) ribonucleoproteins [s(no)RNPs] catalyze 2'-O-

184 pressed histone genes and U small nuclear or nucleolar RNA (sn/snoRNA) loci that form intra- and inte

185 RNAPII-specific spliceosomal snRNA and small nucleolar RNA (snoRNA) genes.

186 transcription termination at noncoding small nucleolar RNA (snoRNA) genes.

187 g (MRP) and mutations in the RNase MRP small nucleolar RNA (snoRNA) subunit of the RNase MRP complex

188 P-ribosylation of histone H2B-Glu35 by small nucleolar RNA (snoRNA)-activated PARP-1 inhibits AMP kin

189 variants of the 333-nucleotide-long U3 small nucleolar RNA (snoRNA).

190 five ncRNA classes (microRNA [miRNA], small nucleolar RNA [snoRNA], small nuclear RNA [snRNA], small

191 ression (which is influenced by miRNA, small nucleolar RNA and lncRNA), activation of K-Ras (mutation

192 rons can be degraded or processed into small nucleolar RNA and microRNA derived from intronic RNA.

193 demonstrate that they are deficient in small nucleolar RNA binding.

194 DEAD-box RNA helicase DDX21 (also named nucleolar RNA helicase 2) is a nuclear autoantigen with

195 5' external transcribed spacer and U3 small nucleolar RNA in providing an intertwined RNA-protein as

196 as rRNA, tRNA, small nuclear RNA, and small nucleolar RNA is likely to affect their function.

197 r rare variants of SNORA31, encoding a small nucleolar RNA of the H/ACA class that are predicted to d

198 bstrate specificity across nucleoplasmic and nucleolar RNA processes.

199 ultiple protein complexes, such as the small nucleolar RNA protein complex.

200 Here we report that the nucleolar RNA proteins Rpp29, fibrillarin, and RPL23a ar

201 transcript, which is regulated by the small nucleolar RNA U1.

202 However, this small nucleolar RNA was not a useful normalizer for cancer ste

203 32 sncRNAs (26 miRNAs, 5 piRNAs, and 1 small nucleolar RNA).

204 ich contains an orphan box H/ACA class small nucleolar RNA, ACA11, in an intron, is associated with s

205 cluding microRNA, long intergenic RNA, small nucleolar RNA, natural antisense transcript, small nucle

206 nge of cellular RNAs, including the U3 small nucleolar RNA, which is essential for processing of 18S

207 drial mt-Nd2, and Snora75, a noncoding small nucleolar RNA.

208 C/D box small nucleolar RNAs (SNORDs) are small noncoding RNAs, and th

209 sis on rRNA, which are guided by H/ACA small nucleolar RNAs (snoRNA).

210 all mRNAs, and non-coding RNAs such as small nucleolar RNAs (snoRNAs) and long non-coding RNAs (lncRN

211 Box C/D small nucleolar RNAs (snoRNAs) and small Cajal body (CB) RNAs

212 Small nucleolar RNAs (snoRNAs) are a class of non-coding RNAs

213 Small nucleolar RNAs (snoRNAs) are a diverse group of non-codi

214 nexpectedly, we found that a subset of small nucleolar RNAs (snoRNAs) are associated with the mammali

215 Box C/D small nucleolar RNAs (snoRNAs) are evolutionarily conserved no

216 Small nucleolar RNAs (snoRNAs) are non-coding RNAs that form r

217 cular Cell, Kim et al. (2019) identify small nucleolar RNAs (snoRNAs) as activators of poly(ADP-ribos

218 Small nucleolar RNAs (SnoRNAs) direct chemical modification of

219 Small nucleolar RNAs (snoRNAs) guide chemical modifications of

220 H/ACA small nucleolar RNAs (snoRNAs) guide pseudouridylation as part

221 Profiling the expression patterns of small nucleolar RNAs (snoRNAs) in joint ageing and OA may prov

222 e, we examined the role of 10 abundant small nucleolar RNAs (snoRNAs) involved in rRNA processing.

223 ily long non-coding RNAs (lncRNAs) and small nucleolar RNAs (snoRNAs) not previously described to be

224 s of 16 tumors identified a cluster of small nucleolar RNAs (snoRNAs) that are highly up-regulated in

225 The non-coding small nucleolar RNAs (snoRNAs) were subject to the greatest le

226 ernal Nm modification can be guided by small nucleolar RNAs (snoRNAs), and that these Nm sites can re

227 1, containing all known orphan C/D box small nucleolar RNAs (snoRNAs), are particularly enriched in s

228 Noncoding RNAs, including small nucleolar RNAs (snoRNAs), play important roles in leukem

229 es detection of NAD(+)-capped intronic small nucleolar RNAs (snoRNAs), suggesting NAD(+) caps can be

230 he elevated expression of a cluster of small nucleolar RNAs (snoRNAs).

231 regulatory ncRNAs such as small nuclear and nucleolar RNAs (snRNAs and snoRNAs).

232 discovery that disruption of specific small nucleolar RNAs protects against fatty acid-induced cell

233 targeted to Snord115 genes, which are small nucleolar RNAs that are clustered in the 3' region of Ub

234 Here we review processing of small nucleolar RNAs that are transcribed by RNA Polymerase II

235 noncoding small RNAs such as snoRNAs (small nucleolar RNAs), tRNA (transfer RNA) fragments, and Y-RN

236 uences, including long noncoding RNAs, small nucleolar RNAs, and untranslated mRNA regions, accomplis

237 ed by a myriad of assembly factors and small nucleolar RNAs, before they reach maturity and enter tra

238 hallmarked by increased expression of small nucleolar RNAs, long noncoding RNAs, microRNAs (miRNAs),

239 ely map RNase-protected regions within small nucleolar RNAs, spliceosomal RNAs, microRNAs, tRNAs, lon

240 is to identify the two main classes of small nucleolar RNAs, the box H/ACA snoRNAs and the box C/D sn

241 Me on rRNA by directly binding C/D box small nucleolar RNAs, thereby modulating translation.

242 cripts including microRNAs, piRNAs and small nucleolar RNAs.

243 NAs, piwi-interacting RNA (piRNA), and small nucleolar RNAs.

244 lls-ribosomal RNAs, transfer RNAs, and small nucleolar RNAs.

245 yeast, the core subunit of the box C/D small nucleolar RNPs, Nop58p, is the target for R2TP function.

246 wn as R-loops at intergenic spacers flanking nucleolar rRNA genes.

247 brosis of explanted hearts and gene-specific nucleolar segregation defects in cardiomyocytes, indicat

248 or inhibition of ribosomal RNA synthesis and nucleolar segregation in response to rDNA breaks.

249 that triggers transcriptional inhibition and nucleolar segregation in response to rDNA breaks.

250 in budding yeast, and the precise course of nucleolar segregation remains unclear.

251 suggesting that rDNA transcription supports nucleolar segregation.

252 cleolar stress and induction of apoptosis by nucleolar sequestration of NF-kappaB/RelA.

253 Our findings indicate that nucleolar sequestration of RAG1 is a negative regulatory

254 iated degradation of SmgGDS, indicating that nucleolar sequestration of SmgGDS by UBF stabilizes SmgG

255 otypes similar to RNA exosome mutants due to nucleolar sequestration of the poly(A)-binding protein (

256 tment of Pol II repressor RENT (regulator of nucleolar silencing and telophase exit) complex at the r

257 How ribosomes get assembled at the nucleolar site by forming initial preribosomal complexes

258 oduction increases with age, indicating that nucleolar size and activity can serve as aging biomarker

259 Knockdown of fibrillarin also reduces nucleolar size and extends lifespan.

260 We further show that nucleolar size correlates with donor age in primary fibr

261 umour suppressor extends lifespan and limits nucleolar size in the major C. elegans longevity pathway

262 Among wildtype C. elegans, individual nucleolar size varies, but is highly predictive for long

263 size was associated with decreased neuronal nucleolar size.

264 g alterations in nuclear shape and increased nucleolar size.

265 We show that nucleolar SmgGDS interacts with the RNA polymerase I tra

266 erval contains several brain-expressed small nucleolar (sno) RNA species that are subject to genomic

267 Eukaryotic box C/D small nucleolar (sno)RNPs catalyse the site-specific 2-O-methy

268 easure changes in RNA flexibility during the nucleolar stages of 60S assembly in yeast.

269 Impairment of IMPDH2 activity triggers nucleolar stress and growth arrest of glioblastoma cells

270 scuss activation of the NF-kappaB pathway by nucleolar stress and induction of apoptosis by nucleolar

271 ribosomal RNA (rRNA) accumulation triggered nucleolar stress and repressed expression of 1392 genes,

272 Physiologically relevant nucleolar stress induction with reactive oxygen species

273 ut not cisplatin, to induce cytotoxicity via nucleolar stress rather than a canonical DNA damage resp

274 The p53-mediated nucleolar stress response associated with inhibition of

275 biogenesis, and activate the Rpl11-Mdm2-p53 nucleolar stress response pathway.

276 MA in rDNA transcription and p53-independent nucleolar stress response supports a central role for th

277 ugh which ribosomal proteins (RPs) transduce nucleolar stress signals via MDM2 to p53 has been descri

278 Downregulation of NuMA expression triggers nucleolar stress, as shown by decreased nascent pre-rRNA

279 t in ribosomal RNA maturation that generates nucleolar stress, leading to stabilization of p53 and ac

280 early event in PS-ASO toxicity, followed by nucleolar stress, p53 activation and apoptotic cell deat

281 or SmgGDS in protecting malignant cells from nucleolar stress, thus promoting cell cycle progression

282 ssome during ribosome biogenesis and repress nucleolar stress.

283 y pre-rRNA processing defects and results in nucleolar stress.

284 ls disrupts nucleolar morphology, signifying nucleolar stress.

285 MA upon actinomycin D or doxorubicin-induced nucleolar stress.

286 1/RPL5-Mdm2 pathway, with characteristics of nucleolar stress.

287 ribosomal biogenesis can initiate so-called nucleolar stress.

288 mall Subunit (SSU) processome and repressing nucleolar stress.

289 ution of nucleophosmin (NPM1) as a marker of nucleolar stress.

290 rphology of the nucleoli exposed an abnormal nucleolar structure in Pf1-deficient cells.

291 Knockdown of RRS1 was sufficient to disrupt nucleolar structures and resulted in activation of p53.

292 ate spatial pattern of Las1L-Nol9 within the nucleolar sub-structure linked with late pre-rRNA proces

293 es the Liat1 poly-K region, and inhibits its nucleolar targeting and potential functions.

294 that FGFR2 mutations in BBDS, which amplify nucleolar targeting of FGFR2, activate ribosomal DNA (rD

295 the underlying mechanisms linking increased nucleolar transcription and tumorigenesis are only minim

296 Ect2 activates rRNA synthesis by binding the nucleolar transcription factor upstream binding factor 1

297 ing the nucleolar proteome without affecting nucleolar transcription initiates the required signallin

298 ocalization sequence that is responsible for nucleolar transport of the assembled Las1L-Nol9 complex.

299 Indeed, the nucleolar volume almost entirely accounts for the extra

300 This surprising kinetics leads to a nucleolar volume distribution, [Formula: see text], unac