ライフサイエンスコーパス: nucleolus

1 mplex with the PIDDosome and NPM1 within the nucleolus.

2 for vectorial ribosomal RNA flux out of the nucleolus.

3 haracterized by structural disruption of the nucleolus.

4 art of a convergent mechanism focused on the nucleolus.

5 of unknown function that can localize to the nucleolus.

6 nslocates with other splicing factors to the nucleolus.

7 a centromere prevented its association with nucleolus.

8 lves phase separation of proteins within the nucleolus.

9 ation resulting from NE expansion around the nucleolus.

10 ng a structure reminiscent of the eukaryotic nucleolus.

11 buting the protein within the nucleus to the nucleolus.

12 ghts into the structural organization of the nucleolus.

13 and Loc1 are localized predominantly in the nucleolus.

14 cence complementation in the nucleoplasm and nucleolus.

15 , a number of whose products localize to the nucleolus.

16 specific nuclear compartment adjacent to the nucleolus.

17 , which recruit Pc and form Pc bodies in the nucleolus.

18 nd is preferentially located adjacent to the nucleolus.

19 ribution of XRN2 between the nucleoplasm and nucleolus.

20 ation signal (NoLS), only p8 is found in the nucleolus.

21 E-2 fragments of pre-rRNA transcript in the nucleolus.

22 Dxz4 and Ds-TR appear to be anchored to the nucleolus.

23 accompanied by their translocation into the nucleolus.

24 extension, or "flare," that encompasses the nucleolus.

25 s critical for formation and function of the nucleolus.

26 rochromatin at the external periphery of the nucleolus.

27 8S rRNAs and assembled into ribosomes in the nucleolus.

28 ne, regulates bone formation from within the nucleolus.

29 gulating protein and DNA interactions at the nucleolus.

30 egulating pluripotency in the oft-overlooked nucleolus.

31 RPS6 and AtHD2B were localized to the nucleolus.

32 nd1 chromosomal segments localized next to a nucleolus.

33 chinery to sense nucleolar stress within the nucleolus.

34 o the nucleus and strongly accumulate in the nucleolus.

35 mine methylation of H2A is restricted to the nucleolus.

36 on is confined to the region adjacent to the nucleolus.

37 opulation showing intense E2 staining of the nucleolus.

38 ylation of rDNA and NOR association with the nucleolus.

39 are tandemly repeated and give origin to the nucleolus.

40 liquid-liquid phase separation (LLPS) in the nucleolus.

41 argeted to the ribosome assembly site in the nucleolus.

42 hering of HP1gamma-enriched chromatin to the nucleolus.

43 nd most steps in SRP biogenesis occur in the nucleolus.

44 vely, fluorescent spots were observed in the nucleolus.

45 5 associates with tRNA gene complexes in the nucleolus.

46 lexes, such as ribosomal subunits within the nucleolus.

47 e-pole body to the immediate vicinity of the nucleolus.

48 f the H1.0-binding proteins are found in the nucleolus.

49 ext of the molecular and cell biology of the nucleolus.

50 RPs) from the cytoplasm into the nucleus and nucleolus.

51 regulates the structure and function of the nucleolus.

52 uclear clustering of the tRNA genes near the nucleolus.

53 with CtBP and localize predominantly to the nucleolus.

54 ately in line with the Shapley value and the nucleolus.

55 , CAL1 localizes to both centromeres and the nucleolus.

56 s with but is nevertheless distinct from the nucleolus.

57 Their component enrichment is located in the nucleolus.

58 components and tTAFs within the spermatocyte nucleolus.

59 e rRNA producing/processing machinery in the nucleolus.

60 ase that targets p53 for degradation, to the nucleolus.

61 S5 complex is found in the cytoplasm and the nucleolus.

62 ss of making ribosomes that initiates in the nucleolus.

63 n regulators, are found to accumulate in the nucleolus.

64 e in a distinctive subnuclear organelle, the nucleolus.

65 izing ribosomal proteins and RNAs within the nucleolus.

66 modulate the viscoelastic properties of the nucleolus.

67 interacts with and relocalizes coilin to the nucleolus.

68 rn maximizes global gene interactions in the nucleolus.

69 iors indicative of active recruitment to the nucleolus.

70 th the increased optical density in the lens nucleolus.

71 tion, morphology and self-interaction of the nucleolus.

72 al (NoLS) and induces disorganization of the nucleolus.

73 hat a split rDNA locus indeed forms a single nucleolus.

74 tion through condensation of the large-scale nucleolus(5-7) or in smaller assemblies known as transcr

75 The nucleolus, a dynamic nuclear compartment long regarded a

76 Although most snoRNAs reside in the nucleolus, a growing body of evidence indicates that sno

77 bosomal DNA (rDNA) array gives origin to the nucleolus, a large nonmembrane-bound organelle that occu

78 es the ribosomal DNA (rDNA) that defines the nucleolus, a major hallmark of nuclear organization.

79 , we investigate the initial assembly of the nucleolus, a membrane-less organelle involved in differe

80 Here, we show that the size of the nucleolus, a membraneless organelle important for cell-s

81 A transient enlargement of the nucleolus accompanied cell division in the Second Mitoti

82 d is essential for PIDDosome assembly in the nucleolus after DNA damage.

83 Conversely, the nucleolus also acts as a first-responder to growth-relat

84 tic marks as well as heterochromatin and the nucleolus also appeared around the 8-cell stage.

85 at 25 Kb resolution, revealing a structured nucleolus, an absence of chromosome territories, and con

86 egment of the genome and gives origin to the nucleolus, an energy intensive nuclear organelle and maj

87 gest and most well-known nuclear body is the nucleolus, an organelle whose primary function in riboso

88 , we now show that AROS localizes to (i) the nucleolus and (ii) cytoplasmic ribosomes.

89 ction can compromise eIF6 recruitment to the nucleolus and 60S ribosome biogenesis.

90 ely held beliefs about the importance of the nucleolus and AAP in AAV assembly and show the heterogen

91 tion, Cdc14 is transiently released from the nucleolus and activated.

92 dentified functions of wild-type NPM1 in the nucleolus and address new biological and clinical issues

93 i are uniquely clustered together within the nucleolus and all major rRNA gene variants, including th

94 n to well-known roles in RNA metabolism, the nucleolus and Cajal bodies (CBs), both located within th

95 how these "infraribosomal" links between the nucleolus and cell cycle progression operate in both for

96 ne the relationship of this structure to the nucleolus and cell division apparatus.

97 e propose that a functional link between the nucleolus and centromere assembly exists in Drosophila,

98 through ordered events that initiate in the nucleolus and culminate in the cytoplasm.

99 TbMTase37 localizes to the nucleolus and depletion of the protein results in accumu

100 ll-length RGH3alpha isoform localizes to the nucleolus and displays a speckled pattern within the nuc

101 NA (TLC1 RNA) is spatially segregated to the nucleolus and excluded from sites of DNA repair in a cel

102 gh two distinct maturation phases inside the nucleolus and follow a regulatory step that precedes lat

103 n led to the re-localization of c-Myc to the nucleolus and increased cellular rRNA expression and pro

104 AV2) showed that assembly takes place in the nucleolus and is dependent on AAP and that capsids coloc

105 We show that FANCI localizes to the nucleolus and is functionally and physically tied to the

106 C-rich rDNA-like substrates that form in the nucleolus and normally inhibit progression of the RNA po

107 The frequency of association with nucleolus and nuclear periphery depends on linear genomi

108 nt kinetics in the two compartments studied (nucleolus and nucleoplasm), suggesting a direct transcri

109 ressed from a plasmid can be detected in the nucleolus and nucleoplasm, but it largely fails to assem

110 markers together with the increased size of nucleolus and nucleus in opnr mutants indicate that OPNR

111 ion of histone H3 and NSP in the nucleus and nucleolus and of histone H3 and MP in the cell periphery

112 The nucleolus and other nuclear bodies behave like liquid-ph

113 The nucleolus and other ribonucleoprotein (RNP) bodies are m

114 f FLCN, dFLCN (a.k.a. dBHD) localizes to the nucleolus and physically interacts with the 19S proteaso

115 n yeast (eco1-W216G) exhibits a disorganized nucleolus and reduced looping at the rDNA.

116 fraction of mammalian BCCIP localizes in the nucleolus and regulates 60S ribosome biogenesis.

117 We confirm that NuMA is present in the nucleolus and reveal redistribution of NuMA upon actinom

118 mature in consecutive steps, starting in the nucleolus and terminating after nuclear export into the

119 a protein that localizes to the nucleus and nucleolus and that interacts with the human enhancer of

120 The relationship between the nucleolus and the centromere, although documented, remai

121 ently tagged CITFA-7 was concentrated in the nucleolus and the ESB.

122 bosomal DNA promoters and is abundant in the nucleolus and the expression site body subnuclear compar

123 The nuclear organelle the nucleolus and the transcription factor nuclear factor of

124 position the inactive X chromosome near the nucleolus and to preserve one of its main epigenetic fea

125 ts that the genes congregate together at the nucleolus and/or centromeres.

126 nd pre-tRNA synthesis, the disruption of the nucleolus, and consequently cell cycle arrest.

127 ity of c-Myc to induce rRNA synthesis in the nucleolus, and constitutive NPM overexpression stimulate

128 zes TIF-IA, induces its translocation to the nucleolus, and enhances its interaction with Pol I.

129 radation, immobilizes the protein within the nucleolus, and results in detergent-insoluble NS.

130 teins that function in RNA metabolism in the nucleolus, and suggest that a new paradigm for linker hi

131 nstrated that Gag and L9 interact within the nucleolus, and the CA domain was the major site of inter

132 ster of meiotic centromeres localizes to the nucleolus, and this association requires centromere func

133 ase complex components localize to the yeast nucleolus, and this localization is essential for mRNA m

134 After migrating to the nucleolus, ANG cleaves promoter-associated RNA, which pr

135 However, the role of the nucleolus as a determinant and organizer of nuclear arch

136 Thus we have identified the nucleolus as a novel site for caspase-2 activation and f

137 The study identifies the nucleolus as a target of inhibitors of NEDDylation and p

138 ighlight acetylation-mediated control of the nucleolus as an important hub linking acetyl-CoA fluctua

139 v's well-known tendency to accumulate at the nucleolus, as well as Rev's capacity to activate optimal

140 ghts into still poorly understood aspects of nucleolus-associated diseases, including cancer, ribosom

141 We have found H1.0 to be enriched at nucleolus-associated DNA repeats and chromatin domains,

142 olus or to the nuclear lamina, thus defining nucleolus-associated domains (NADs) and lamina-associate

143 in nuclear organization and function - from nucleolus-associated domains (NADs) to the regulation of

144 ) long, nucleoplasmic filaments; (ii) short, nucleolus-associated filaments; and (iii) dense, nucleop

145 ction of NPM1 in the spatial organization of nucleolus-associated heterochromatin.

146 oops, domains, compartments, and lamina- and nucleolus-associated regions, have been discovered.

147 y cotranscriptionally and passes through the nucleolus before its nuclear export.

148 h, binding concentrated in the nuclei to the nucleolus but not the chromatins.

149 ry for the export of rDNA breaks outside the nucleolus but required for timely repair of meiotic DSBs

150 mutation not only delocalizes NPM1 from the nucleolus, but it also disorganizes promyelocytic leukem

151 ing maturation of the 90S preribosome in the nucleolus, but that translocation of L13a into the nucle

152 stry, we found that Liat1 is targeted to the nucleolus by a low-complexity poly-K region within its I

153 nto ribosomes and is degraded in the nucleus/nucleolus by a ubiquitin-proteasome system quality contr

154 Specifically, in the nucleolus, c-Myc has been shown to be recruited to ribos

155 ypal intracellular condensates-including the nucleolus, Cajal bodies, stress granules and P-bodies-im

156 shold concentration of Cry2olig protein, the nucleolus can be gelled into a tightly linked, low mobil

157 tase Cdc14 was released prematurely from the nucleolus concomitant with hyperphosphorylation of its n

158 oteins are required for the integrity of the nucleolus, containing ribosomal DNA repeats, the nucleop

159 In addition, the nucleolus contributes to neuronal stress responses, incl

160 ises the fundamental question of whether the nucleolus controls p53 directly, i.e., as a site where p

161 In the nucleolus, DDX21 occupies the transcribed rDNA locus, di

162 ized in the dense fibrillar component of the nucleolus dependently on active RNA polymerase I transcr

163 and -11, and AAP, assembled capsids, and the nucleolus do not colocalize for all the serotypes.

164 rk (MEN) releases Cdc14 phosphatase from the nucleolus during anaphase, leading to the inactivation o

165 Cdc55 maintains Cdc14 sequestration in the nucleolus during early meiosis, and this is essential fo

166 dc14B, a mammalian orthologue, also exit the nucleolus during interphase upon DNA replication stress

167 sociated domains [NADs]) and proteins to the nucleolus during interphase.

168 and that capsids colocalize with AAP in the nucleolus during the assembly process.

169 P1 is tightly regulated and expressed in the nucleolus during the G1/S phases.

170 iptionally active and are recruited into the nucleolus early in meiosis.

171 h, and its product is nuclear localized with nucleolus enrichment.

172 sporting the viral capsid VP3 protein to the nucleolus for assembly.

173 ow a desumoylation enzyme is targeted to the nucleolus for removing SUMO from specific substrates and

174 hromatin to release bulk rRNA genes into the nucleolus for ribosome production, which fuels single nu

175 We demonstrate that the nucleolus formation is precisely timed in D. melanogaste

176 sistent with the role of rRNA in seeding the nucleolus formation.

177 vitro and dynamically colocalise within the nucleolus from early to mid S-phase.

178 first, we demonstrate deep conservation of a nucleolus gene module across very divergent organisms, a

179 The rDNA/nucleolus has been directly and mechanistically implicat

180 Although, the nucleolus has been observed for almost 200 years in neur

181 The rDNA/nucleolus has emerged as a coordinating hub in which see

182 The nucleolus has emerged as a platform for the organization

183 ctor (NKRF) as a nucleolar HSP essential for nucleolus homeostasis and cell survival under proteotoxi

184 h HSV-2 ICP34.5 proteins are detected in the nucleolus, ICP34.5alpha is predominantly located in cyto

185 ways in which the material properties of the nucleolus impact its function in rRNA biogenesis are not

186 yl-CoA depletion alters the integrity of the nucleolus, impairing ribosomal RNA synthesis and evoking

187 urrent notions about the role of AAP and the nucleolus in capsid assembly.

188 tivity promotes TLC1 RNA localization in the nucleolus in G2/M.

189 hology and increases the surface size of the nucleolus in human and germline cells of Caenorhabditis

190 (K0) localizes in both the cytoplasm and the nucleolus in neuronal SH-SY5Y cells.

191 We discuss the role of rDNA and the nucleolus in nuclear organization and function - from nu

192 dent p53 activation, implying a role for the nucleolus in p53 activation by ribosomal biogenesis stre

193 d noncoding RNAs immobilizes proteins in the nucleolus in response to a specific stimulus.

194 with the bulk of the DNA in one lobe and the nucleolus in the other.

195 V5, -8, and -9 capsids are excluded from the nucleolus, in contrast to the nucleolar enrichment of as

196 ing for chromatin components that target the nucleolus, including CTCF and HP1beta.

197 h stimulate PARP-1 catalytic activity in the nucleolus independent of DNA damage.

198 s that multiple rDNA loci will form a single nucleolus independent of their location within the genom

199 nzymatic activity and translocation from the nucleolus into nucleoplasm.

200 Both RECQL5 and WRN re-localize from the nucleolus into the nucleus after replicative stress and

201 biogenesis, which takes place mainly in the nucleolus, involves coordinated expression of pre-riboso

202 The synthesis of ribosomal subunits in the nucleolus is a conserved, essential process that results

203 The nucleolus is a membrane-less organelle formed through li

204 The nucleolus is a membraneless organelle of the nucleus and

205 The nucleolus is a plurifunctional organelle in which struct

206 The nucleolus is a prominent nuclear condensate that plays a

207 Our findings demonstrate that the nucleolus is an essential protein quality control center

208 Accumulation of ARF in the nucleolus is associated with poor outcome and attenuated

209 own as the center of ribosome synthesis, the nucleolus is connected to cell cycle regulation in more

210 Ribosomal subunit assembly in the nucleolus is dependent on efficient targeting of ribosom

211 GDS to interact with UBF and localize in the nucleolus is diminished by expressing DiRas1 or DiRas2,

212 Consequently, the nucleolus is displaced.

213 cript levels increase substantially when the nucleolus is disrupted.

214 cellular center of ribosome biogenesis, the nucleolus is essential for the growth of developing neur

215 The nucleolus is formed around repeats of a transcriptional

216 The remodeling of chromatin in the nucleolus is important for the control of ribosomal DNA

217 Since the nucleolus is known to play a key role in cell growth, th

218 e multicopy rRNA gene clusters (rDNA) in the nucleolus is less well understood.

219 The p8 location in the nucleolus is linked to a bipartite NoLS.

220 lus, but that translocation of L13a into the nucleolus is not sufficient for its incorporation into r

221 Our model demonstrates the nucleolus is phase separated from other chromatin in the

222 ive-cell imaging, we observed that the yeast nucleolus is reorganized in its protein composition duri

223 The nucleolus is the most prominent nuclear body and serves

224 shoot apical meristems and FEN1-GFP shows a nucleolus-localized signal in tobacco cells.

225 Although disruption of the nucleolus may trigger the p53-dependent neuronal death,

226 and ribosomal RNA remodelling events in the nucleolus, nucleoplasm and cytoplasm.

227 bosome biogenesis occurs successively in the nucleolus, nucleoplasm, and cytoplasm.

228 Moreover, we find that nucleolus-nucleoplasm interface is maintained by ATP-dep

229 i in vivo, while monitoring the shape of the nucleolus-nucleoplasm interface.

230 Under stress conditions, NKRF directs XRN2 nucleolus/nucleoplasm trafficking, controlling 5'-to-3'

231 ly repeated ribosomal DNA that comprises the nucleolus of budding yeast.

232 the 3' end of scR1, which accumulates in the nucleolus of cells lacking the activities of these compl

233 for megagametogenesis and is enriched in the nucleolus of meiotic and mitotic cells.

234 In addition, SMN can also be detected in the nucleolus of neurons.

235 a significant pool of ECT2 localizes to the nucleolus of non-small-cell lung cancer (NSCLC) cells, w

236 yelocytic leukemia protein bodies and to the nucleolus of the cell, the site of RNA polymerase I-medi

237 osslinks between 5kbp domains (genes) in the nucleolus on Chromosome XII; and, temporal network model

238 The influence of the nucleolus on nuclear organization undoubtedly modulates

239 l heterochromatin is located adjacent to the nucleolus or to the nuclear lamina, thus defining nucleo

240 The nucleolus, organized around arrays of rRNA genes (rDNA),

241 ll silenced rRNA gene subtypes mapped to the nucleolus organizer region (NOR) on chromosome 2 (NOR2).

242 variants of 45S rDNA and their corresponding nucleolus organizer regions (NOR).

243 Nucleolus organizer regions (NORs) are chromosomal loci

244 housands of 45S rRNA gene copies localize in Nucleolus Organizer Regions (NORs), and the activation o

245 man nucleoli and particularly the five human nucleolus organizers have not been well characterized.

246 ers: cell shape, MT array, nucleus position, nucleolus position, and chromatin condensation.

247 to the nuclear envelope associated with the nucleolus, possibly to avoid disruption of intranuclear

248 a small NE expansion occurs adjacent to the nucleolus prior to anaphase in a Cdc5-dependent manner.

249 ts into membrane-less organelles such as the nucleolus, processing bodies or stress granules(1,2).

250 The accumulation of MtgA around the nucleolus promotes a similar accumulation of the endopla

251 cleoplasm in interphase nuclei, whereas, the nucleolus region exhibited a more prominent immuno-posit

252 ing, to show that subcompartments within the nucleolus represent distinct, coexisting liquid phases.

253 increasing support for the concept that the nucleolus represents a multilayered biomolecular condens

254 localizes and stabilizes p19(Arf) within the nucleolus, require p19(Arf) N-terminal amino acids that

255 e protein-protein interaction network in the nucleolus required for nucleolar structure and integrity

256 minantly in the deubiquitinated state in the nucleolus, requiring the nucleoplasmic deubiquitinase (D

257 it is unable to localize in the nucleus and nucleolus, respectively.

258 ropose that nuclear sub-domains, such as the nucleolus, result from phase separations within the nucl

259 and the formation of a single, peri-nuclear nucleolus results in the clustering of rDNA.

260 Here, we demonstrate that PHF6 is a nucleolus, ribosomal RNA promoter-associated protein.

261 The nucleolus serves as a principal site of ribosome biogene

262 y repetitive DNA, such as those found in the nucleolus, show a self-organization that is marked by sp

263 Nucleolus size is an indicator of ribosome biogenesis an

264 This reduction in nucleolus size required Dpp and Hh signaling.

265 In this study, nucleolus size was monitored during cell fate specificat

266 hat are insulin-responsive and also regulate nucleolus size, we enriched for Myc target genes require

267 Further experiments revealed that this nucleolus stress-induced cell cycle arrest involves the

268 NPM1 was mainly expressed in nucleus and nucleolus subcellular compartments.

269 e isolated NC domain of Gag localized to the nucleolus, suggesting that it contains a nucleolar local

270 However, unlike the nucleolus, these assemblies are highly variable in numbe

271 xt of RNA-processing condensates such as the nucleolus, this manifests in the selective exclusion of

272 cells and specifically appears to target the nucleolus through a nucleolar localization signal (NoLS)

273 stic nucleation step in the formation of the nucleolus, through a seeding mechanism.

274 y tethering ribosomal protein L11 within the nucleolus to repress the binding of L11 to the E3 ligase

275 he creation of this structure and allows the nucleolus to retain its tripartite organization and tran

276 d by a complex pathway that extends from the nucleolus to the cytoplasm and is powered by many energy

277 ors that propel ribosome maturation from the nucleolus to the cytoplasm.

278 cts as a thermosensor translocating from the nucleolus to the nucleoplasm during heat stress; nucleol

279 orms, causing their re-localization from the nucleolus to the nucleoplasm.

280 nslocation of de-phosphorylated NPM from the nucleolus to the nucleoplasm.

281 changes as pre-ribosomes transition from the nucleolus to the nucleoplasm.

282 ion induced a translocation of AATF from the nucleolus to the nucleus, thereby enabling its physical

283 that in SBV-infected cells, B23 undergoes a nucleolus-to-nucleoplasm redistribution, evocative of vi

284 structural and functional adaptation of the nucleolus, triggered by heat shock or physiological acid

285 The untimely release of Cdc14 from the nucleolus upon activation of Hog1 is linked to a defect

286 t, all of which are under the control of the nucleolus upon stress.

287 tein content and structural integrity of the nucleolus using the H1 triple isoform knockout (H1DeltaT

288 t nucleophosmin (NPM1) integrates within the nucleolus via a multi-modal mechanism involving multival

289 Although the nucleolus was first described in the early 19(th) centur

290 e H1 and protein-protein interactions in the nucleolus, we used biochemical and proteomics approaches

291 nucleus, which included 1) mRNAs within the nucleolus when nucleocytoplasmic transport, rRNA biogene

292 iation of Pol III-transcribed genes with the nucleolus, when permitted by global chromosome architect

293 S effector, VgpA, localizes to the host cell nucleolus where it binds Epstein-Barr virus nuclear anti

294 s reflecting a structure like the eukaryotic nucleolus where many different ribosomal RNA operons are

295 uction of Dicer altered the structure of the nucleolus, where pre-rRNA processing occurs.

296 y to the nucleus, but is concentrated in the nucleolus, where the early pre-rRNA processing reactions

297 dence for translation in the nucleoplasm and nucleolus, which is regulated by infectious and chemical

298 nuclear extension always coincided with the nucleolus, while the morphology of the DNA mass remained

299 ighted the active viscoelastic nature of the nucleolus, whose material properties and phase behavior

300 , structural maintenance and function of the nucleolus, with implications for gene regulation and rib