ライフサイエンスコーパス: nucleophilic addition

1 eamine and rapidly succumbed to irreversible nucleophilic addition.

2 reactivity of their quinone moieties toward nucleophilic addition.

3 al furnishes a cation which is vulnerable to nucleophilic addition.

4 accepts the hydroxide proton only after the nucleophilic addition.

5 )-triene through a beta-chelation-controlled nucleophilic addition.

6 enter, expanding the synthetic scope of this nucleophilic addition.

7 C(7)-H alkenylation with alkynes followed by nucleophilic addition.

8 drogen transfer oxidation and a Ru-catalyzed nucleophilic addition.

9 aces wherein only one face is accessible for nucleophilic addition.

10 mechanism based on THIQ oxidation and R(3)In nucleophilic addition.

11 to selectively activate the C9 carbonyl for nucleophilic addition.

12 trode by simple immersion, follows Micheal's nucleophilic addition.

13 preference of hydrogen-atom abstraction over nucleophilic addition.

14 ne to benzvalene followed by protonation and nucleophilic addition.

15 that then undergo highly diastereoselective nucleophilic additions.

16 phosphonium intermediates for the subsequent nucleophilic additions.

17 adical pathways, they can also be trapped by nucleophilic addition, a pathway supported by computatio

18 luoro-o-benzoquinone (o-fluoranil) undergoes nucleophilic additions, addition-eliminations, dioxole f

19 ts are incorporated via stereocontrolled 1,2-nucleophilic addition and anti-aldol coupling, respectiv

20 intermediate compounds was consistent with a nucleophilic addition and aromatization formation mechan

21 he preferred site of attack observed in both nucleophilic addition and cycloaddition experiments.

22 which in turn governs regioselectivities in nucleophilic addition and cycloaddition reactions.

23 developed, which proceeds through sequential nucleophilic addition and electrophilic substitution fol

24 ation of thiourea followed by regioselective nucleophilic addition and intramolecular ring-closing wi

25 utational studies clarified the roles of the nucleophilic addition and nitrogen extrusion steps and t

26 ions and alpha-silyl carbanions utilized for nucleophilic addition and Peterson olefination reactions

27 wo reversible covalent chemistries involving nucleophilic additions and acid-base reactions, challeng

28 the surprisingly high regioselectivities in nucleophilic additions and cycloadditions to 4,5-indolyn

29 ion modes, including diverse cycloadditions, nucleophilic additions and sigma-bond insertions.

30 reate a desired cascade triad (coordination, nucleophilic addition, and reductive elimination).

31 the conserved cysteine in the active site by nucleophilic addition, and such substrate-based aldehyde

32 cloadditions, Birch reduction, many types of nucleophilic additions, and electrophilic addition to ar

33 ioselective processes, including reductions, nucleophilic additions, and reductive couplings.

34 erted 1,2-aryl transfer; proto-demetalation; nucleophilic addition; and solvent-assisted methanol eli

35 ure, in turn, does not necessarily favor the nucleophilic addition, as shown for the reaction with fl

36 Does the isomerase enzyme RPE65 operate via nucleophilic addition at C(11) of the all-trans substrat

37 e-pot acid-mediated transannular cyclization/nucleophilic addition at C7 furnished the corresponding

38 tion, the His activates a water molecule for nucleophilic addition at the thiouronium C zeta atom to

39 to a metastable intermediate via a dominant nucleophilic addition barrier.

40 e synthesized via solvent- and catalyst-free nucleophilic addition between PEG-diamine and vitamin E-

41 e chemistry: "Proton transfer," "Bimolecular nucleophilic addition," "Bimolecular nucleophilic substi

42 to activate the substrate toward a potential nucleophilic addition but also to subtly control the reg

43 ric tetrayne intermediate, which undergoes a nucleophilic addition by 1 equiv of ethylamine.

44 ng mechanism has been proposed that involves nucleophilic addition by histidine, cysteine, or lysine

45 termediate was found to undergo nonenzymatic nucleophilic addition by N-acetyl-l-cysteine to generate

46 Our results support the conclusion that nucleophilic addition by the kinase onto the C-21 positi

47 of 8, followed by a series of oxidations and nucleophilic additions by N3-.

48 Tandem nucleophilic addition/C-C bond cleaving fragmentation re

49 ote chemo-, regio-, and stereocontrol in the nucleophilic addition can be achieved with chiral phosph

50 om skipped diynones and allylic alcohols via nucleophilic addition/Claisen rearrangement/cyclization

51 f photocycloaddition, cis-hydroxylation, and nucleophilic addition constructs both quaternary carbons

52 idines has been developed by using cascade N-nucleophilic addition-cyclic Michael addition process of

53 ions of the graphene sp(2) backbone, such as nucleophilic addition, cycloaddition, free radical addit

54 incorporation precedes cyclodehydration in a nucleophilic-addition-cyclodehydration (NAC) sequence.

55 effective for allylic alkoxides prepared by nucleophilic addition, deprotonation, or reduction.

56 aldehydes generally lead to the formation of nucleophilic addition derived products when Cs(2)CO(3)/E

57 xylation, C-C bond formation, intramolecular nucleophilic addition, desaturation and C-C bond cleavag

58 entral to the synthetic approach is a tandem nucleophilic addition-diastereoselective axial reduction

59 d including decarboxylation, dehalogenation, nucleophilic addition, dimerisation, oxidation, Norrish

60 The resulting Mannich product from nucleophilic addition eliminates sulfinic acid, yielding

61 ceed via a radical mechanism but rather by a nucleophilic addition-elimination mechanism.

62 base and that catalysis proceeds through the nucleophilic addition-elimination mechanism.

63 , and they may not follow radical but rather nucleophilic addition-elimination mechanisms.

64 rotonated alpha-oxoketene intermediates 3 or nucleophilic addition-elimination pathways.

65 no acids via NH(2) abstraction (a nonradical nucleophilic addition-elimination reaction).

66 The entire sequence includes nucleophilic addition-elimination, Seyferth-Gilbert homo

67 e thermal reversion is the result of a novel nucleophilic addition/elimination mechanism.

68 -trichlorodipyrromethene hydrochloride after nucleophilic addition/elimination, with adventitious chl

69 oxy-allyl cation prior to the stereodefining nucleophilic addition event.

70 tion and correlate with the rate of aromatic nucleophilic addition five chemical bonds away.

71 sion from enol diazoacetates with vinylogous nucleophilic addition followed by Lewis acid catalyzed c

72 Sequential sulfur nucleophilic addition followed by Liebeskind-Srogl cross

73 er, under thermodynamic reaction conditions, nucleophilic addition followed by ring opening produced

74 ceptor and proton donor) functionality, with nucleophilic addition following closely behind (nucleoph

75 tivity and excellent enantioselectivities in nucleophilic addition (formal carbonyl-ene reaction) to

76 dly with the alcohol group of cholesterol by nucleophilic addition, forming a hemiacetal salt.

77 Bimolecular nucleophilic addition generates bent 1,3-zwitterions.

78 was a single enantiomer and, therefore, that nucleophilic addition had taken place on the enzyme.

79 Boron acids can activate diols toward nucleophilic additions; however, the design of stable ch

80 milar chemical permutations to chorismate by nucleophilic addition (hydroxyl or amine) at the 2-posit

81 Lys-97-general-acid catalysis of the O2'(-) nucleophilic addition; (ii) expulsion of three water mol

82 the iminium precursor that was subjected to nucleophilic addition in a diastereoselective manner.

83 ptibility of a coordinated carbonyl group to nucleophilic addition in the former, facilitating the fo

84 To understand the effect of nucleophilic addition in wine, a white wine with the sam

85 dem decarboxylation, proton abstraction, and nucleophilic addition, in good yields with excellent sel

86 g the type(s) of product arising either from nucleophilic addition (indanes) or loss of a proton beta

87 ce supporting the ring cleavage of ACC via a nucleophilic addition initiated process, thus establishi

88 in a rare example of asymmetric bimolecular nucleophilic addition into an oxocarbenium ion.

89 Terminating the process through bimolecular nucleophilic addition into the intermediate provides a v

90 on related transformations where the initial nucleophilic addition involving the activated allenoate

91 y has been used to show that the position of nucleophilic addition is at C(1).

92 ot been reported, and the preferred site for nucleophilic addition is unknown and unexplored.

93 computational results, a so far unpublished nucleophilic addition mechanism is the lowest energy pat

94 ride transfer, hydrogen atom transfer, and a nucleophilic addition mechanism) have now been analyzed

95 -tosyloxy-beta-lactams through a concomitant nucleophilic addition/N-O bond reduction reaction, a mil

96 Diastereoselectivity of the nucleophilic addition of (Z)-HC triple bond C(CH(3))=CHC

97 The potential for dimer formation from the nucleophilic addition of 2-methyltetrol to trans-beta-IE

98 pyridines is described that proceeds through nucleophilic addition of a dithiane anion to an alpha,be

99 he second cyclization through intramolecular nucleophilic addition of a heteoatom nucleophile to the

100 on the nitronyl carbon could facilitate the nucleophilic addition of a hydroxyl group onto the nitro

101 Following stereocontrolled nucleophilic addition of a methyl group to 33, ring A wa

102 ing suggests that the reaction proceeds by a nucleophilic addition of a phenylacetamide carbanion, wh

103 Azo coupling is followed by a nucleophilic addition of a second indole unit to the ind

104 lent immobilization was achieved through the nucleophilic addition of a terminal amine (located on a

105 cationic intermediate which is vulnerable to nucleophilic addition of a tethered amine group.

106 Additionally, its decay is driven by the nucleophilic addition of a water molecule, which occurs

107 fer hydrogenation of ketimines, while in the nucleophilic addition of acetylacetone to N-Boc protecte

108 Nucleophilic addition of alkoxide to these N-arylquinazo

109 coration of the nonplanar polyarene upon the nucleophilic addition of alkoxy groups to the exterior c

110 ed allyl vinyl ethers are synthesized by the nucleophilic addition of allyl oxides to phosphorus-subs

111 The reaction proceeds via the nucleophilic addition of an active methylene compound to

112 trile moiety, 5-exo cyclization, followed by nucleophilic addition of an alkanethiol to a 3-alkyliden

113 The reaction proceeds via nucleophilic addition of an alkanethiol to an isonitrile

114 t the ene reaction proceeds through a unique nucleophilic addition of an allene double bond to a cati

115 activity and that the mechanism involves the nucleophilic addition of an anionic metal-oxo species to

116 This nucleophilic addition of an Fe(3+)-O-O(-) intermediate t

117 The nucleophilic addition of aryl Grignard reagents to eithe

118 steric crowding at both reactive sites, the nucleophilic addition of C8' over N1' to the C3 carbocat

119 Parallel studies considering nucleophilic addition of Cmpd 0 to the aldehyde intermed

120 oenzyme M transferase (EaCoMT) catalyzes the nucleophilic addition of coenzyme M (CoM, 2-mercaptoetha

121 s in bacterial propylene metabolism from the nucleophilic addition of coenzyme M to (R)- and (S)-epox

122 Epoxide metabolism is initiated by the nucleophilic addition of coenzyme M to the (R)- and (S)-

123 cific binding site in rutin that facilitates nucleophilic addition of cyanide has been unveiled for t

124 l acid) and that the energy barriers for the nucleophilic addition of Cys thiolate to the thiouronium

125 haI enzyme has been considered as a stepwise nucleophilic addition of Cys-81-S- to cytosine C6 follow

126 The key steps included nucleophilic addition of difluoromethyl phenyl sulfone t

127 on reaction probably involves intramolecular nucleophilic addition of epoxide oxygen to open another

128 urs through an associative process involving nucleophilic addition of free hydroxyl groups to the car

129 Nucleophilic addition of Grignard reagents and organolit

130 produced directly from DCAN chlorination via nucleophilic addition of hypochlorite on the nitrile car

131 Upon nucleophilic addition of indoles, indolylenamides were o

132 ted triazene intermediate resulting from the nucleophilic addition of LDA on the diazo moiety, suppor

133 Nucleophilic addition of lithiated TBS-protected proparg

134 of methanol with PQQ in the absence of Ca2+, nucleophilic addition of methanol to the PQQ C-5 carbony

135 ening/C-C bond cleavage reactions induced by nucleophilic addition of methyl Grignard to 5,6-dihydro-

136 hydroxyl groups are necessary to promote the nucleophilic addition of MGO by HT and related compounds

137 Base-mediated nucleophilic addition of N-methoxy sulfonamides, followe

138 ce-dependent intrastrand cross-links via the nucleophilic addition of N3-thymidine to C8-guanine (5'-

139 lculations show that acetamide forms through nucleophilic addition of NH(3) to a surface-bound ketene

140 -methoxycarbonylpentadienyl)-Fe(CO)2PPh3+ by nucleophilic addition of nitromethane anion followed by

141 id thioureas efficiently catalyze asymmetric nucleophilic addition of nitromethane to ketimines deriv

142 The nucleophilic addition of organomagnesium and organolithi

143 The fluoride-catalyzed nucleophilic addition of PhSCF(2)SiMe(3) (1) to chiral i

144 Fluoride-mediated diastereoselective nucleophilic addition of PhSCF(2)SiMe(3) to chiral N-ter

145 ategy involved sequential fluoride-catalyzed nucleophilic addition of PhSCF2SiMe3 (1) to 2,2-diallyla

146 The fluoride-catalyzed nucleophilic addition of PhSCF2SiMe3 to both maleic anhy

147 The strategy involves fluoride-catalyzed nucleophilic addition of PhSCF2TMS (5) to chiral ketocyc

148 alpha-vinyl anion generated in situ through nucleophilic addition of PPh(3) to the activated alkyne.

149 r-catalyzed strategy for the stereoselective nucleophilic addition of propargylic and other alkyl gro

150 ates twice as much alpha-tocopherol due to a nucleophilic addition of short alcohols on the BHT oxida

151 ed a wide distribution in reactivity for the nucleophilic addition of SMZ.

152 SO2ClF, and SO2F2 to carbenium ions and the nucleophilic addition of SO2 to 1,2-bridged halonium ion

153 The nucleophilic addition of SO2, SO2ClF, and SO2F2 to carbe

154 al benzene photoreaction: the photoinitiated nucleophilic addition of solvent to benzene in acidic me

155 The Marcus intrinsic barrier for nucleophilic addition of solvent water to the "extended"

156 revealed an ~10(5)-fold rate enhancement for nucleophilic addition of sulfide into the trisulfide ver

157 iles for the stereoselective, intramolecular nucleophilic addition of sulfonimidoyl carbanions to for

158 The nucleophilic addition of the aminothiols homocysteine (H

159 tease undergo a Michael reaction mediated by nucleophilic addition of the enzyme's catalytic Cys-147,

160 tial role in LTQ biogenesis by directing the nucleophilic addition of the epsilon-amino group of a ly

161 ation of alkynes, followed by intramolecular nucleophilic addition of the generated carbon-palladium

162 Nucleophilic addition of the Gly67 amide nitrogen to the

163 system undergoes a reversible, nonoxidative nucleophilic addition of the guest molecules to the meta

164 miacetal activation proceeds through initial nucleophilic addition of the hemiacetal hydroxyl to the

165 gh a complex cascade of steps triggered by a nucleophilic addition of the imine nitrogen atom.

166 t an ionic reaction pathway initiated with a nucleophilic addition of the in situ formed iodoamine to

167 Nucleophilic addition of the nitrile to an activated int

168 The overall process involves nucleophilic addition of the nitrogen atom of the sulfil

169 dene complex is followed by a cyclization by nucleophilic addition of the olefinic group to Cgamma of

170 mechanism for these transformations includes nucleophilic addition of the protein thiol to a nitroso

171 alkoxide ligand on a second coordinated THF, nucleophilic addition of the resultant alkoxide ligand t

172 ov electrocyclization of divinyl ketones and nucleophilic addition of the resulting 2-oxidocyclopente

173 The second cyclization proceeds via nucleophilic addition of the resulting olefinic unit to

174 olved, as the key step, a diastereoselective nucleophilic addition of the Ruppert-Prakash reagent (TM

175 The reaction proceeds through the nucleophilic addition of the Ser203 O to the carbonyl C

176 taneous processes, which proceed through the nucleophilic addition of the Ser203-Ogamma to the carbon

177 I) catalyst, which causes the intramolecular nucleophilic addition of the sulfonamide unit to the alk

178 Nucleophilic addition of thiolates to diethyl acetylened

179 ss a,a-difluoroalkylthioethers could involve nucleophilic addition of thiols across gem-difluorostyre

180 The key stereocontrolled step involves nucleophilic addition of trimethylsilyl cyanide to the a

181 The double nucleophilic addition of two molecules of indole to one

182 pecies, very likely formed by intermolecular nucleophilic addition of two nitrone molecules, was also

183 BF(3).OEt(2)-catalyzed nucleophilic addition of vinyl azides to in situ generat

184 eps of synthesis were (i) diastereoselective nucleophilic addition of vinylmagnesium bromide to N-all

185 be a function of tyrosinase rather than the nucleophilic addition of water to dopaquinone.

186 ure, such as retro-Diels-Alder reactions and nucleophilic addition of water.

187 Nucleophilic addition of water138 to ribooxocarbenium io

188 Nucleophilic additions of alpha-mercaptoalkanoate esters

189 tial bonding of STZ occurred by 1,2- and 1,4-nucleophilic additions of the aromatic amino group to qu

190 lytic capability of GSTs is catalysis of the nucleophilic addition or substitution of glutathione at

191 nd the competing mechanisms involving either nucleophilic addition or the formation of radical interm

192 For chlorinated and brominated aromatics, nucleophilic addition ortho to carbon-halogen bonds via

193 of the alkylating reagents occurs, favoring nucleophilic addition over competitive hydrolysis.

194 NAAA) cases where electron donation from the nucleophilic addition partner activates the alkene for e

195 This nucleophilic addition process has been shown to be rever

196 the triplets including quenching and various nucleophilic addition processes.

197 and UV-vis-NIR experiments and isolated the nucleophilic addition product [(Me)(Ph)(CCHC){Au(IPr)}(2

198 f a single trans-beta-IEPOX + 2-methyltetrol nucleophilic addition product was obtained, but nucleoph

199 tituted azuliporphyrins 19 demonstrated that nucleophilic addition products were present in equilibri

200 Subsequent nucleophilic addition re-aromatizes the intermediates to

201 , metal-bound Cys can be easily labeled in a nucleophilic addition reaction after separation by rever

202 tect cyanide (CN(-)) based on a Michael-type nucleophilic addition reaction and intramolecular charge

203 a Diels-Alder reaction and an intermolecular nucleophilic addition reaction as the key steps.

204 polymeric ligands are built using a one-step nucleophilic addition reaction between poly(isobutylene-

205 Five-component sequential Ugi/nucleophilic addition reaction of aromatic aldehydes, pr

206 rast to 1-chloro-2,4-dinitrobenzene, for the nucleophilic addition reaction of GSH to ethacrynic acid

207 h that the peroxy intermediate can perform a nucleophilic addition reaction to the substrate, NOHA.

208 nstrated here in a tandem cycloisomerization/nucleophilic addition reaction, by attaining high enanti

209 l azide formation, Curtius rearrangement and nucleophilic addition reaction.

210 isobutylene-alt-maleic anhydride), PIMA, via nucleophilic addition reaction.

211 formation via a tandem cyclic N-acyliminium nucleophilic addition reaction.

212 n reactions instead of the commonly proposed nucleophilic addition reaction.

213 e-alt-maleic anhydride) chain via a one-step nucleophilic addition reaction.

214 Nucleophilic addition reactions compete with two electro

215 This Article demonstrates how nucleophilic addition reactions mediated by photoredox c

216 inals undergo both intra- and intermolecular nucleophilic addition reactions mediated by strong Lewis

217 is system as a method to expand the scope of nucleophilic addition reactions to carbon-carbon multipl

218 o a variety of reduction, cycloaddition, and nucleophilic addition reactions to form highly substitut

219 rived chiral phosphoric acids for a range of nucleophilic addition reactions to imines and developed

220 m complexes undergo intra- or intermolecular nucleophilic addition reactions with stabilized enolates

221 with quinone moieties in organic matter via nucleophilic addition reactions.

222 ase via tandem N-acyliminium ion cyclization-nucleophilic addition reactions.

223 by reaction type, for example condensation, nucleophilic addition, reduction and oxidation, substitu

224 ariety of chemical transformations including nucleophilic additions, reductive aminations, Stille cou

225 the reaction coordinate for electrophilic or nucleophilic addition, respectively.

226 ate the ketone's conjugation is disrupted by nucleophilic addition, resulting in a blue shift of the

227 al transformations, including regioselective nucleophilic addition, selective nitrogen alkylation, an

228 xyl nucleophile and the intrinsic KIE on the nucleophilic addition step (ca. 0.981).

229 er conjugate addition processes focus on the nucleophilic addition step as stereochemistry-determinin

230 n nitro and chloro substituents indicate the nucleophilic addition step is rate determining.

231 lower the activation energy barrier for the nucleophilic addition step.

232 nd regiochemistry for both electrophilic and nucleophilic addition steps.

233 zaarenes to activate adjacent alkenes toward nucleophilic additions, the enantioselective reductive c

234 Nucleophilic addition to 1,3-dimethyl-5-phenyl-1,4,5,6-t

235 nane 17 followed by a highly stereoselective nucleophilic addition to 17 employing DIBAL, NaBH4, and

236 a model reaction to study the acid-catalyzed nucleophilic addition to a carbonyl group.

237 iol moiety was installed through a selective nucleophilic addition to a hydroxy 1,2-diketone.

238 yclic diketoester starting materials through nucleophilic addition to a ketene is also described.

239 rahedral intermediate, which is generated by nucleophilic addition to a Weinreb amide, rather than by

240 he prochiral oxocarbenium ion are subject to nucleophilic addition to afford a statistical mixture of

241 of the KOH/DMSO superbase catalyzed ketones nucleophilic addition to alkyl propargyl and alkyl allen

242 A key factor in the development of selective nucleophilic addition to allenamides is controlling the

243 rmation and catalyze either hydrogenation or nucleophilic addition to alpha,beta-unsaturated aldehyde

244 nonitrileoxime, HONC(CN)(2), with respect to nucleophilic addition to ammonia, methylamine, hydroxyla

245 is proposed for predicting the outcome of a nucleophilic addition to an alpha-chiral ketone.

246 This study establishes the feasibility of nucleophilic addition to an appended sulfoxide as a mean

247 ished using a novel strategy that involves a nucleophilic addition to an N-acyl iminium ion, a ring-c

248 sulfoxide or sulfide substrate, for steering nucleophilic addition to C(3) of the indole.

249 Nucleophilic addition to carbon-nitrogen double bonds (i

250 portant ideas regarding the mechanism of the nucleophilic addition to carbonyl groups.

251 l agents are often synthesized by asymmetric nucleophilic addition to carbonyls.

252 te, followed by an asymmetric intramolecular nucleophilic addition to form chiral cyclic N,S-acetals

253 may be further elaborated by protonation and nucleophilic addition to generate chroman analogues with

254 be coupled with an intra- or intermolecular nucleophilic addition to generate new carbon-carbon or c

255 ly undergoes stereoelectronically controlled nucleophilic addition to give substituted tetrahydrofura

256 tron-withdrawing and -donating groups on the nucleophilic addition to oxocarbenium ion intermediates.

257 ed from our group, whereby it was shown that nucleophilic addition to p-benzynes derived from unsymme

258 A subsequent nucleophilic addition to silicon removes the acetal dire

259 The rates of nucleophilic addition to substituted QMs measured by las

260 ition of hydroxide, in which the key step is nucleophilic addition to the 8-oxoG radical cation; and

261 Conversely, nucleophilic addition to the aldehyde and dehydrative ar

262 rate-determining step of this reaction is a nucleophilic addition to the alkene double bond, which i

263 Nucleophilic addition to the alkynylcyclopropenylium ion

264 ment of new transformations involving direct nucleophilic addition to the amide bond as a key step.

265 products in excellent yields through direct nucleophilic addition to the amide bond.

266 a mechanism by which chloride ion undergoes nucleophilic addition to the benzylic C-10 position of a

267 Nucleophilic addition to the carbonyl group followed by

268 ecifically addresses the question of whether nucleophilic addition to the carbonyl groups of acid chl

269 Key steps are a totally diastereoselective nucleophilic addition to the cyclic nitrone followed by

270 In situ nucleophilic addition to the cycloaddition-derived imini

271 alitatively, these results are indicative of nucleophilic addition to the enone being the rate-limiti

272 e derivatives followed by diastereoselective nucleophilic addition to the hydrazone products constitu

273 Reactivity studies demonstrate rapid nucleophilic addition to the N-C(O) moiety of N-alkylate

274 dence for DNA cross-link formation involving nucleophilic addition to the quinone subunit is describe

275 + 2] cycloadduct, which involves an initial nucleophilic addition to the readily formed beta-phospho

276 number of remarkably stable hemiaminals upon nucleophilic addition to the twisted amide bonds present

277 The stereoselectivity of nucleophilic additions to 3-azidoalkanals was investigat

278 Nucleophilic additions to 3-tert-butylbenzyne, which is

279 Nucleophilic additions to alpha-chiral alpha-halo carbon

280 Anh diastereoselectivity can be achieved for nucleophilic additions to alpha-chiral ketones upon stre

281 to the Felkin-Anh and Cram-chelation models, nucleophilic additions to alpha-silyloxy aldehydes proce

282 rresponding iodoalkynes to affect sequential nucleophilic additions to aromatic aldehydes.

283 Despite significant efforts, direct nucleophilic additions to heteroaromatics have remained

284 in selectivities are attributed to rates of nucleophilic additions to oxocarbenium ion intermediates

285 ronic effects on the diastereoselectivity of nucleophilic additions to the carbonyl group, a series o

286 cation oxidations is suggested, premised on nucleophilic additions to the oxygen atom of the positiv

287 -flow processes (amidation and Mg-I exchange/nucleophilic addition) to demonstrate the flexibility of

288 ryl migration, followed by an intramolecular nucleophilic addition, to give benzoxazole products in g

289 Boronic acid inhibitors often undergo nucleophilic addition upon binding to an enzyme due to t

290 associated with low reactivity of imines in nucleophilic addition, various imines with electron-with

291 y role in lowering the activation energy for nucleophilic addition via formation of a preferential hy

292 s first with hydroxyalkyl azides followed by nucleophilic addition was also developed.

293 e activation of CPyI by metal cations toward nucleophilic addition was found to directly correspond t

294 quinone redox couple was used to monitor the nucleophilic addition, while simulated CVs compared to e

295 luoroacetaldehyde also efficiently underwent nucleophilic addition with 2-arylindazoles.

296 mplexes can undergo a second protonation and nucleophilic addition with a range of nucleophiles inclu

297 fully taken through a second protonation and nucleophilic addition with a similar scope of nucleophil

298 ined to pseudoequatorial positions underwent nucleophilic addition with selectivity that was comparab

299 addition followed by intramolecular O- and N-nucleophilic addition with the formation of the correspo

300 m of the -N=C=S group can undergo successive nucleophilic additions with reagents containing two sulf