ライフサイエンスコーパス: nucleophilic attack

1 onic substrate bias to influence the site of nucleophilic attack.

2 s create the in-line trajectory required for nucleophilic attack.

3 accounts for the feasibility of the initial nucleophilic attack.

4 ys and the susceptibility of the products to nucleophilic attack.

5 Thioester linkage is cleaved by nucleophilic attack.

6 ost electron-deficient and might be prone to nucleophilic attack.

7 nd interact directly with Thr-413 to promote nucleophilic attack.

8 o a different reaction mechanism involving a nucleophilic attack.

9 , such as nitro groups, to superoxide-driven nucleophilic attack.

10 es its ability to activate pi-systems toward nucleophilic attack.

11 can efficiently protect the loaded dye from nucleophilic attack.

12 s correctly orient the carboxamide group for nucleophilic attack.

13 +), and Cys348 faces the wrong direction for nucleophilic attack.

14 hydrolytic water molecule more favorably for nucleophilic attack.

15 ade between this reaction and other modes of nucleophilic attack.

16 and the cofactor, priming the substrate for nucleophilic attack.

17 Fenton chemistry, heterolytic cleavage, and nucleophilic attack.

18 Glu76 may facilitate this autocleavage in a nucleophilic attack.

19 activating the aziridine intermediate toward nucleophilic attack.

20 ote electrophilic center to facilitate OH(-) nucleophilic attack.

21 manner through an unexpected intramolecular nucleophilic attack.

22 ically raises the activation barrier for the nucleophilic attack.

23 hyrin carbene accomplishes N-H insertion via nucleophilic attack.

24 formation of benzyl carbocation, followed by nucleophilic attacks.

25 tive site to activate the water molecule for nucleophilic attack?

26 se structural methods reveals details of the nucleophilic attack and identifies a novel enzyme-produc

27 s to accomplish this step, single-site water nucleophilic attack and O-O radical coupling, are discus

28 vel cycloisomerization based on ring-opening nucleophilic attack and rearrangement is observed.

29 urther reveal that both intermolecular water nucleophilic attack and redox isomerization of {[LCu(III

30 terionic nature of 1 was also susceptible to nucleophilic attacks and cycloaddition reactions by and

31 A variety of nucleophilic attacks (and THF polymerization) on the coo

32 d to a proton transfer (PCNA: proton-coupled nucleophilic attack) and a subsequent decomposition of t

33 rn motif activates the carbonyl group toward nucleophilic attack, and chemical transformation of this

34 ion include azide and nitro group reduction, nucleophilic attack, and CuS precipitation.

35 s in this reaction: it decomposes the PCs by nucleophilic attack, and in the subsequent polyether for

36 lso positions the labile linkage for in-line nucleophilic attack, and thus twister appears to simulta

37 ng "preactivation" of the (1)C(4) complex to nucleophilic attack as reflected by free energy, C1-O1/O

38 tic equatorial ligands facilitates the water nucleophilic attack, as in the case of the highly effici

39 The amine is proposed to perform a nucleophilic attack at a terminal eta(2)-carboxylate lig

40 Products arising from nucleophilic attack at all conceivable sites, that is, a

41 ubsequent preferred mode of fragmentation by nucleophilic attack at C9 or C12.

42 stitution of iodide at the metal followed by nucleophilic attack at carbon by a second amine.

43 ch aliphatics, showing no apFr, preventing a nucleophilic attack at P after lithiation.

44 ples of iriduim allyl complexes that undergo nucleophilic attack at terminal position, rather than th

45 0 promotes catalysis by activating water for nucleophilic attack at the 5'-phosphate group with respe

46 s proceed with high regioselectivity through nucleophilic attack at the C-6 position of the pyrone ri

47 (1) the "anchor-relay" mechanism mediated by nucleophilic attack at the carbonyl and (2) direct attac

48 such as Fe(CO)5 and Cr(CO)6 react with 1 via nucleophilic attack at the carbonyl carbon atom to give

49 g the inward approach of indoles, leading to nucleophilic attack at the less substituted electrophili

50 of the ligand framework directs and promotes nucleophilic attack at the ligand gold complex-activated

51 aziridines by trimethylsilylazide, inducing nucleophilic attack at the primary position of one enant

52 h ARH3- and ARH1-catalyzed reactions involve nucleophilic attacks at the C-1'' position, it was perpl

53 fonate protecting group that is resistant to nucleophilic attack but readily removed with trifluoroac

54 ate formed by Flp(R191A) can be targeted for nucleophilic attack by a 5'-hydroxyl or water and channe

55 (b) Nucleophilic attack by a carboxylate on the amide carbon

56 hiometric Si-N bond-forming reaction suggest nucleophilic attack by a magnesium amide as the turnover

57 rgo self-catalyzed endoproteolysis involving nucleophilic attack by a molecule of cholesterol.

58 ) is a much better target for the subsequent nucleophilic attack by a negatively charged OH(-) than t

59 This species subsequently undergoes nucleophilic attack by a second equivalent of NH2OH, for

60 ramidimidoyl fluoride to a protein can allow nucleophilic attack by a specific amino acid side chain,

61 This process depends on nucleophilic attack by a substrate lysine on a thioester

62 a(5) -Cp)(BDI)](+) (3(+) ), which allows for nucleophilic attack by a variety of reagents under mild

63 ate of an ATP molecule is undergoing in-line nucleophilic attack by a water molecule.

64 vinylglycine ketimine, which is subjected to nucleophilic attack by acetoacetate to form the new C(ga

65 This intermediate undergoes nucleophilic attack by an N-terminal poly-Gly sequence t

66 The rates of nucleophilic attack by aniline and by N-methylaniline on

67 and a multistep mechanism starting with the nucleophilic attack by benzamidine on an in situ generat

68 imide activates a carboxyl group followed by nucleophilic attack by benzhydrazide forming a stable la

69 For CH(3)Br, nucleophilic attack by both H(2)O and Cl(-) caused signi

70 n of a diazo intermediate which encounters a nucleophilic attack by carbonyl oxygen on the electrophi

71 avage of P horizontal lineSe bond is through nucleophilic attack by carboxylate instead of alkylamine

72 es the electrophilic carbonyl group toward a nucleophilic attack by CN(-) in aqueous environment.

73 The reaction catalyzed by APR involves the nucleophilic attack by conserved Cys-249 on adenosine 5'

74 This makes this Si-C bond subject to nucleophilic attack by F(-), triflate, and alkoxide/ethe

75 Nucleophilic attack by free pyridine at the alpha-carbon

76 of the N-chlorinated amidic N-C bond due to nucleophilic attack by hydroxyl ions.

77 uces CO(2) by one electron transfer (ET) via nucleophilic attack by its N lone pair on the C of CO(2)

78 ent with Lewis acid/base chemistry involving nucleophilic attack by N5 of FAD(red) at C1 of UDP-Galf/

79 a concerted S(N)2-like mechanism, in which a nucleophilic attack by O(Ser), facilitated by proton tra

80 C2 position, which is usually susceptible to nucleophilic attack by OH(-).

81 Subsequent nucleophilic attack by pyridyl nitrogen results in its c

82 Cys-256 of PaAPR is the point of the initial nucleophilic attack by reduced thioredoxin, mutagenic re

83 h formation of a tetrahedral oxyanion during nucleophilic attack by Ser112.

84 tants suggests a reaction mechanism in which nucleophilic attack by sulfate on the alpha-phosphate of

85 tion of C with arginine 224 and prevents the nucleophilic attack by the 3' hydroxyl group of cytidine

86 sitioning of the phosphotyrosine linkage for nucleophilic attack by the 3'-OH end to result in DNA re

87 RNA substrate for activation and subsequent nucleophilic attack by the 5'-hydroxyl of the second RNA

88 acarbenium ion like transition states during nucleophilic attack by the acceptor.

89 mbers of the nitrilase superfamily, in which nucleophilic attack by the active site cysteine generate

90 tion of the N-allyl imine and the subsequent nucleophilic attack by the alpha-alkyl cyanoester produc

91 In contrast, nucleophilic attack by the alpha-aryl cyanoester exclusi

92 esolution of this intermediate upon specific nucleophilic attack by the conserved lysine located with

93 ine with the anomeric carbon atom poised for nucleophilic attack by the FAD N5 atom.

94 ergy of its carbonyl LUMO, activating it for nucleophilic attack by the Fe-O2 intermediate formed alo

95 placing BPDE in a favorable orientation for nucleophilic attack by the N(2) position of guanine.

96 rted back to the enzyme-inhibitor complex by nucleophilic attack by the newly created amino group.

97 amide derivatives followed by intramolecular nucleophilic attack by the nitrogen of the benzamide moi

98 th carbonyl oxygen, promoting intermolecular nucleophilic attack by the only weakly nucleophilic amid

99 with a minimal amount of chain transfer from nucleophilic attack by the phosphite.

100 ation of the analogs is suitable for in-line nucleophilic attack by the ribose O3' on alpha-phosphate

101 romoted catalytic mechanism, invoking direct nucleophilic attack by the substrate alpha-amino group o

102 32 intermediates, the latter is subject to a nucleophilic attack by the unmodified histidine; and fin

103 ubiquitin-conjugating enzyme (E2) undergoes nucleophilic attack by the varepsilon-amino group of an

104 This facilitates the nucleophilic attack by the water oxygen at the phosphate

105 One frequently cited proposal is the nucleophilic attack by water hydroxide on a pendant Mn h

106 of a reaction that utilized a metal-mediated nucleophilic attack by water on the phosphoester.

107 phosphate surrogate is arranged to disfavor nucleophilic attack by water.

108 tion and reactants prior to the irreversible nucleophilic attack by water.

109 ty promotes the sealing of DNA backbones via nucleophilic attacks by the 5'-hydroxyl on the 2',3'-cyc

110 ng junction (C5-C6) and trans at the site of nucleophilic attack (C6-C7) on the three contiguous ster

111 yclic double bond present in series I toward nucleophilic attack, compounds containing either an endo

112 sient phosphorane formed as a result of this nucleophilic attack decays by breaking the bond between

113 mulates a reaction intermediate of the first nucleophilic attack during catalysis of cysteine peptida

114 The preferred mode of nucleophilic attack forms the product in a conformation

115 oy carbon-based electrophiles, which undergo nucleophilic attack from limited spatial orientations an

116 heir d-orbitals and consequently can undergo nucleophilic attack from many spatial orientations.

117 The latter undergoes intramolecular nucleophilic attack from Nbeta to the protonated -CN gro

118 cyclization, consisting of an intramolecular nucleophilic attack from the central carbon of the allen

119 coming nucleotide, which is essential before nucleophilic attack from the primer RNA 3'-hydroxyl.

120 different reactivities of E/Z-dienamines in nucleophilic attacks from the other face.

121 redirect the actions of these side chains to nucleophilic attack, generating rate enhancements that a

122 obenzyl alcohols --> in situ intramolecular "nucleophilic attack" --> "hydrolysis" is presented, for

123 The protonation state of His523 during nucleophilic attack has also been investigated, and our

124 ion that helps activate the 2'-hydroxyl for nucleophilic attack has been characterized biochemically

125 the catalytic base that activates water for nucleophilic attack in IS and SS reactions; in AS and AD

126 hile the benzoquinone form is susceptible to nucleophilic attack in Michael-type additions, hydroquin

127 The ester bond of peptidyl-tRNA undergoes nucleophilic attack in solution and when catalyzed by th

128 n state, in such a way that the preferential nucleophilic attack is oriented to the opposite enantiot

129 rates we find that at low pH the OH(-) anion nucleophilic attack is the rate-limiting step, which cha

130 on and DFT calculations indicate a concerted nucleophilic attack mechanism.

131 chanics (QM/MM) simulation, we show that the nucleophilic attack occurs at the alpha-phosphate site.

132 n in the GMII Michaelis complex and that the nucleophilic attack occurs before complete departure of

133 ceed via a common rate-determining step, the nucleophilic attack of 3-5 at the Michael acceptors with

134 ver mechanism, and the cyclization occurs by nucleophilic attack of a conveniently positioned phospho

135 allenes via a tandem process that involves a nucleophilic attack of a cyanide ion and a Brook rearran

136 culations suggest a mechanism proceeding via nucleophilic attack of a dicoordinate borylene intermedi

137 etic sequence (11 steps, 46% global) are the nucleophilic attack of a hindered tertiary alkoxide, a r

138 tions revealed that the reactions proceed by nucleophilic attack of a metal amide at the incoming sil

139 In an alternative outer-sphere process, nucleophilic attack of a metal-phosphido (M-PR(2)) group

140 med early and a higher energetic barrier for nucleophilic attack of a water molecule on the high ener

141 lves three sequential steps and requires the nucleophilic attack of a water molecule on the substrate

142 This pathway involves the rate-limiting nucleophilic attack of a water molecule, leading to a sh

143 in which GTP is cleaved into GDP and P(i) by nucleophilic attack of a water molecule.

144 ng the zinc rearrange quickly to promote the nucleophilic attack of a zinc-bound hydroxide ion onto t

145 echanism to hydrolyze the DNA substrate is a nucleophilic attack of an active site water molecule to

146 etc.) are consistent with turnover-limiting nucleophilic attack of an electrophilic [L2Pd(allyl)]+ c

147 ring expansion of methylenecyclopropanes and nucleophilic attack of an enamine to realize the constru

148 ed by N activation of the azine, followed by nucleophilic attack of an isocyanide in a Reissert-type

149 catalytic base is responsible for initiating nucleophilic attack of ATP and for relaying the positive

150 formation of azido-pyranoquinolines through nucleophilic attack of azide on pyrilium intermediate ov

151 -phase N-glycosidic bond cleavage induced by nucleophilic attack of C1' with a hydroxide ion in 5-sub

152 the P horizontal lineSe bond is initiated by nucleophilic attack of carboxylate on a Cd(2+)-activated

153 tion of the amino group of glycine, enabling nucleophilic attack of CTQ, as well as the deprotonation

154 This can be attributed to the nucleophilic attack of Cys to the alpha,beta-unsaturated

155 oposed catalytic mechanism of DNMT1 involves nucleophilic attack of Cys(1226) to cytosine (Cyt) C6, m

156 Using force-clamp spectroscopy, we monitor nucleophilic attack of Cys-111 at either sulfur of the d

157 ates that denitration of GTN is initiated by nucleophilic attack of Cys-302 at one of the terminal ni

158 n energetically preferred mechanism in which nucleophilic attack of cytosine C5 on the S-adenosyl-L-m

159 -diamine complex or a thiol adduct formed by nucleophilic attack of either the amine group or the sul

160 This transformation takes place via nucleophilic attack of enol ethers to electron-rich benz

161 ction proceeds via an inner-sphere mechanism-nucleophilic attack of enolate oxygen on Palladium follo

162 RuCl2((13)CH2PCy3)(NHC) (py)2 resulting from nucleophilic attack of free PCy3 on the methylidene liga

163 a Ni-pai-allyl complex, and the outer-sphere nucleophilic attack of H-bonded amine aggregates is prop

164 FEPO functions via epoxide ring opening upon nucleophilic attack of H2S.

165 nd enhance the autoxidation by promoting the nucleophilic attack of heme.

166 ions showed that the scission takes place by nucleophilic attack of hydroxide on the ketone followed

167 Next, we propose a nucleophilic attack of molybdate onto the gamma-phosphat

168 ss the double bond to trigger the subsequent nucleophilic attack of NADPH, by the negatively charged

169 by an intramolecular N-N bond formation via nucleophilic attack of one of the azo nitrogen onto the

170 resence of either DBU, or enolates formed by nucleophilic attack of PCy3 on methyl acrylate.

171 en atom transfer reaction is consistent with nucleophilic attack of phosphorus on an electrophilic me

172 Conformational analysis of nucleophilic attack of putative intermediate glycosyl ox

173 n of the oxyanion ligand (RO(-)) followed by nucleophilic attack of RO(-) on a cationic Pd(IV)-alkyl

174 Nucleophilic attack of silanolate onto the carbonyl of t

175 dopalladation pathway with turnover-limiting nucleophilic attack of sulfonamide on the coordinated al

176 ibitors of reactive oxygen species suggest a nucleophilic attack of superoxide radical anion followed

177 structures and fundamental pathways for the nucleophilic attack of terminal Zn-OH sites are comparab

178 trate, UDP-N-acetylglucosamine, promotes the nucleophilic attack of the 3-hydroxyl group of 1-L-myo-i

179 ing step in the reaction, the intramolecular nucleophilic attack of the alcohol into the enol ester r

180 igh selectivity is attributed to the ease of nucleophilic attack of the aldehydes by the methoxy inte

181 ction is best described as an intramolecular nucleophilic attack of the amidate ligand on the coordin

182 many bases, with subsequent cyclization via nucleophilic attack of the amide N(-) to alkynyl.

183 ed to yield five- or six-membered lactams by nucleophilic attack of the amide nitrogen onto the tripl

184 hemistry implies that the reaction occurs by nucleophilic attack of the amine on a coordinated alkene

185 e complex as the resting state, implies that nucleophilic attack of the amine on the alkene is revers

186 lexibility of the alkylamine facilitates the nucleophilic attack of the amine on the reactants.

187 However, the nucleophilic attack of the anion on carbonates induces a

188 ted by an electron transfer step followed by nucleophilic attack of the aryl ring onto the nitrogen o

189 the acidic surface silanols followed by the nucleophilic attack of the basic amine functional group

190 wc25 lock the branch helix into position for nucleophilic attack of the branch adenosine at the 5' sp

191 volves protonation of the carbamate species, nucleophilic attack of the carbamic acid, and formation

192 vorable pathways were predicted instead: the nucleophilic attack of the carbene lone pair on the imin

193 , promoted by halide anion, with concomitant nucleophilic attack of the created carboxylate anion on

194 ages: (i) a thiol-disulfide exchange through nucleophilic attack of the Cys53-thiolate to the GSSG-di

195 a necessary deprotonation step prior to its nucleophilic attack of the DNA.

196 ne more than one mechanism on the basis of a nucleophilic attack of the formaldehyde O atom to the W

197 Notably, the intramolecular nucleophilic attack of the hydroxyl group took place on

198 nfluence of structural factors affecting the nucleophilic attack of the imidazolyl group on the phosp

199 ts a stepwise mechanism in which the initial nucleophilic attack of the iodonium ylide at the iminium

200 provide cyclic peroxyketals, presumably via nucleophilic attack of the methyl ketone product.

201 ep of the mechanism is proposed to involve a nucleophilic attack of the Ni(I) active state (MCR(red1)

202 r-catalyzed cyclization by an intramolecular nucleophilic attack of the nitrogen on the ketene, affor

203 corresponded to the 5-exo-dig intramolecular nucleophilic attack of the oxygen of the benzamide moiet

204 This binding mode does not allow optimal nucleophilic attack of the peptidyl-tRNA by the reactive

205 t the translocase reaction can proceed via a nucleophilic attack of the phosphate moiety of C35-P on

206 two zinc ions activate a water molecule for nucleophilic attack of the phosphodiester bond.

207 ions indicate that the reaction proceeds via nucleophilic attack of the phthalimide on an aromatic ra

208 ctivity was modeled theoretically, revealing nucleophilic attack of the pi* orbital of CO by the nitr

209 hanistic step between nucleotide binding and nucleophilic attack of the primer 3'-hydroxyl group on t

210 that involves H-bonding Pd-O(H)...H-CF3 and nucleophilic attack of the promoter on the metal, follow

211 mical assays to suggest that Lys33 initiates nucleophilic attack of the propeptide by deprotonating t

212 Neither nucleophilic attack of the resonance-stabilized ester by

213 Both paths are initiated by nucleophilic attack of the ribose O2' oxygen on the neig

214 ridging hydroxide is in optimal position for nucleophilic attack of the scissile phosphate.

215 e adsorbed amine to differ with respect to a nucleophilic attack of the surface species.

216 e hydroalkynylation reaction takes place via nucleophilic attack of the terminal alkyne to the C2 car

217 e, supporting a reaction mechanism involving nucleophilic attack of the triphenylphosphine HOMO at th

218 mechanism for this reaction consisting of a nucleophilic attack of the urate anion on the flavin hyd

219 The reaction is initiated by nucleophilic attack of the vinyl ethers at the vinylogou

220 hedral intermediate that is formed after the nucleophilic attack of the water molecule to the substra

221 , at copper this conversion proceeds through nucleophilic attack of thiol RSH on the bound nitrite in

222 on process and that the adduct is formed via nucleophilic attack of UAE thioester by the sulfamate gr

223 tions, a mechanism is proposed that involves nucleophilic attack of water at boron followed by rate-l

224 Concurrent nucleophilic attack of water molecules coming directly f

225 n of the O-O bond proceeds on these sites by nucleophilic attack of water on a bridging oxo.

226 compared to the gas phase and occurs through nucleophilic attack of water on the carbonyl carbon.

227 properties of the transition state (TS) for nucleophilic attack of water on the gamma-PO3(-) group b

228 thyridine-based ligand architecture promotes nucleophilic attack of water to the metal-bound COD.

229 dicate the formation of alpha-terpineol by a nucleophilic attack of water.

230 ion-state intermediate that results from the nucleophilic attack of zinc-bound water at the active si

231 cles and polycyclic amines by intramolecular nucleophilic attack on a Michael acceptor with an allyli

232 anistic possibilities include intramolecular nucleophilic attack on an aryne intermediate leading to

233 ated in the correct position to initiate the nucleophilic attack on ATP to form the carboxyphosphate

234 ch now can cleave the target disulfide via a nucleophilic attack on either one of its two sulfur atom

235 eptor residue, which subsequently performs a nucleophilic attack on FAD for flavin transfer.

236 can be used to enable highly stereoselective nucleophilic attack on intermediate tertiary carbocation

237 f copper(I)-catalyzed cascade intramolecular nucleophilic attack on N-sulfonylketenimine followed by

238 ion, suggesting how Cbl can be activated for nucleophilic attack on oQ.

239 Nucleophilic attack on phosphorus is confirmed by the de

240 lation of biocatalytic activity for tyrosine nucleophilic attack on phosphorus.

241 Moreover, MS data also indicated that nucleophilic attack on PL at the C2-C3 olefin led to PL

242 Nucleophilic attack on seven-membered-ring oxocarbenium

243 The synthetic sequence merges well with the nucleophilic attack on the 2-amino group of pyridines/py

244 gly, we observe that the peptide causing the nucleophilic attack on the acyl-enzyme intermediate must

245 gen bonding between diol groups that induces nucleophilic attack on the alkene and then proton transf

246 with the dATP substrate suggests an in-line nucleophilic attack on the alpha-phosphate center as a p

247 e of the catalytic threonines during L-ASP's nucleophilic attack on the amide carbon.

248 , cellobiose, positions a water molecule for nucleophilic attack on the anomeric carbon of the glycos

249 asynchronous transition state, resembling a nucleophilic attack on the aryne.

250 or deprotonation of Tyr77 of Rab1b to enable nucleophilic attack on the ATP.

251 nitial peroxo-anion intermediate, poised for nucleophilic attack on the C20 position by a substrate-a

252 automerization and generating a serinate for nucleophilic attack on the C6-carbonyl.

253 ect stereoelectronic alignment to enable the nucleophilic attack on the carbonyl carbon by the cataly

254 and the water molecule that carries out the nucleophilic attack on the carbonyl carbon of the scissi

255 itin and positions its alpha-amino group for nucleophilic attack on the E3 approximately ubiquitin th

256 bunit interface, is positioned to catalyze a nucleophilic attack on the gamma-phosphate of a bound nu

257 to position the catalytic water molecule for nucleophilic attack on the gamma-phosphate of GTP.

258 to a series of amide products through amine nucleophilic attack on the ketene intermediate.

259 a weakly coordinating counterion showed that nucleophilic attack on the less stable allyliridium spec

260 r protonated forms could react with HANs via nucleophilic attack on the nitrile carbon, forming the c

261 site but is imperfectly oriented to launch a nucleophilic attack on the phosphate backbone.

262 lysis of the ester is followed by a putative nucleophilic attack on the phosphorus by the carboxyl gr

263 oxyl pinned in place by a serine, leading to nucleophilic attack on the scissile phosphate.

264 drogen bond is no longer present, leading to nucleophilic attack on the substrate intermediate C-S bo

265 the metal-bound water ligand for subsequent nucleophilic attack on the substrate.

266 l theory calculations suggest that the water nucleophilic attack on the surface-bound Ru(V) horizonta

267 ting an adjacent serine residue carrying out nucleophilic attack, opening the cyanuric acid ring, and

268 ents show the viability of an intramolecular nucleophilic attack over an intermolecular attack of the

269 atalysts proceed through a single-site water nucleophilic attack pathway.

270 ive site Pb2+ ion helps to stabilize in-line nucleophilic attack, provides direct electrostatic trans

271 is proposed to proceed through an S(N)2-like nucleophilic attack/ring-opening manifold.

272 3) C-F bonds into C-Si bonds by two modes of nucleophilic attack (S(N) V or S(N) 2').

273 ine configuration (E- or Z-imine) and on the nucleophilic attack site (top or bottom).

274 4 kcal/mol calculated for the barrier of the nucleophilic attack step to reach a definitive conclusio

275 ter molecule in the initial rate-determining nucleophilic attack step, and then shuttles it to the am

276 Subsequently, the nucleophilic attack takes place followed by a second pro

277 Subsequently, the nucleophilic attack takes place, with the formation of a

278 e CRISPR repeat, and finally, it catalyses a nucleophilic attack that connects one strand of the lead

279 f configuration, followed by an outer sphere nucleophilic attack that leads to a second inversion of

280 oxide activation of persulfate (reduction or nucleophilic attack) the results were consistent with re

281 rm the C-Cl bond prior to the intramolecular nucleophilic attack to form the C-N bond, while one path

282 ubstrate's carboxylated phenyl group makes a nucleophilic attack to form the pyrrole ring of the indo

283 ut a reaction pathway that is concerted with nucleophilic attack to generate a similar phosphorane.

284 The proposed mechanism involves a nucleophilic attack to NO by the alcohol, coupled to a p

285 nism for the O-O bond formation is the water nucleophilic attack to single Co(IV)-oxo or Co(III)-oxyl

286 the interrupted cascade from the 6-endo-dig nucleophilic attack to the fragmentation of the central

287 rates, and control experiments revealed that nucleophilic attack to the pai-allylpalladium intermedia

288 Comparison of the rates of nucleophilic attack to the rates of epimerization of the

289 s has been explained in terms of competitive nucleophilic attacks to different positions of the carbe

290 fluoride group can be the exclusive site of nucleophilic attack under defined conditions, making the

291 oxyl, while the other carboxylate engages in nucleophilic attack upon the amide carbonyl; a substanti

292 The site of nucleophilic attack was determined by conducting the hyd

293 Nucleophilic attack was observed at the carbon that is b

294 from A-1(O2') to a nonbridging oxygen during nucleophilic attack, was also considered but deemed to b

295 n N-terminal cysteine pKa lower than 6.5 for nucleophilic attack, whereas the pKa of the C-terminal c

296 y a dual role in activating the donor toward nucleophilic attack while at the same time providing tra

297 Based on these data, we proposed that nucleophilic attack with a subsequent water-assisted Los

298 Finally, we probe the initial nucleophilic attack with ab initio simulations.

299 on treatment with aqueous H2SO4 proceeded by nucleophilic attack with inversion at C(2) preferentiall

300 observed directly, and its susceptibility to nucleophilic attack with various nucleophiles as well as