ライフサイエンスコーパス: nucleophilicity

1 ectrophilicity), and hydrogen-bond basicity (nucleophilicity).

2 ir at N (consistent with observed N-centered nucleophilicity).

3 dianion were unsuccessful because of its low nucleophilicity.

4 he bridging hydroxide ion and increasing its nucleophilicity.

5 not alter its pK(a) in order to improve its nucleophilicity.

6 th control gp120, indicating induction of Ab nucleophilicity.

7 iveness of DCI is thought to be based on its nucleophilicity.

8 ds such as decamethonium, which is devoid of nucleophilicity.

9 th the elevated pK and the enhanced apparent nucleophilicity.

10 the active site serine, thus increasing its nucleophilicity.

11 , as cysteine is well suited due to its high nucleophilicity.

12 thway using lignin-derived phenols with high nucleophilicity.

13 ch relies on only single chemical feature of nucleophilicity.

14 ften been omitted in studies regarding alpha-nucleophilicity.

15 gy, low solubility and impaired fluoride ion nucleophilicity.

16 nd carbonyl moiety and the decrease of amide nucleophilicity.

17 on points for attachment owing to their high nucleophilicity.

18 sence of solvents where acidity predominates nucleophilicity.

19 s been precluded by its intrinsically weaker nucleophilicity.

20 rate peptides/proteins and that increase its nucleophilicity.

21 e nucleophilic proton and thus enhancing the nucleophilicity.

22 onsible for the electron-deficient carbene's nucleophilicity.

23 ne effect that is the origin of the enhanced nucleophilicity.

24 easoned to be a consequence of varying amine nucleophilicity.

25 three commonly used NHCs of vastly different nucleophilicity, 1,3-di-tert-butylimidazolin-2-ylidene (

26 ization to compensate for the attenuation of nucleophilicity(4).

27 es a mechanism for enhancing cysteine/serine nucleophilicity, a property shared by many active site t

28 ap distances captures trends in aromaticity, nucleophilicity, allotrope stability, and substituent ef

29 ted basicities (pK(aH)) do not show enhanced nucleophilicities (alpha-effect) for either hydrazines o

30 l stability of ceMoS(2) was regulated by the nucleophilicities and the resultant charging effects of

31 nto two independent components, an intrinsic nucleophilicity and a thermodynamic driving force determ

32 amide NH to the thiolate sulfur reduces the nucleophilicity and consequently, the rate of alkylation

33 A strong correlation between sequence nucleophilicity and cross-linking yield was observed, an

34 o group in aminoperoxides has remarkably low nucleophilicity and does not participate in the usual am

35 difluorocarbene (Pd=CF(2)) species with both nucleophilicity and electrophilicity by switching the va

36 rst step toward systematically understanding nucleophilicity and electrophilicity in the absence of a

37 e rNHCs has been studied by evaluating their nucleophilicity and electrophilicity indices.

38 hese carbenes has been discussed in terms of nucleophilicity and electrophilicity indices.

39 constants are approximated here using Mayr's nucleophilicity and electrophilicity parameters fine-tun

40 Group nucleophilicity and electrophilicity profiles help descr

41 nt targeting of RAS(G12D) is hindered by low nucleophilicity and high proteomic abundance of carboxyl

42 or the formylation of thiols using CO(2) via nucleophilicity and hydrodefluorination of aryl fluoride

43 tic thiol 1 was selected due to its enhanced nucleophilicity and its enhanced leaving-group ability r

44 Crucial to success is the nucleophilicity and less steric hindrance on the nitroge

45 egativity of tellurium gave rise to superior nucleophilicity and Lewis basicity of the isotellurourea

46 systematic study of tunable yet competitive nucleophilicity and Lewis basicity of water against nove

47 alpha-dihalo-beta-acetoxyketones through the nucleophilicity and Lewis basicity of water, respectivel

48 orientation of a cytoplasmic loop to enhance nucleophilicity and modification of a nearby cysteine (C

49 al approach capitalizes on the inherent weak nucleophilicity and oxidative properties of arginine.

50 ng mass transfer of substrates and products, nucleophilicity and proton transfer at the active site,

51 ll molecule electrophiles despite their weak nucleophilicity and provide the basis for the developmen

52 Each of these approaches exploits the strong nucleophilicity and reducing potency of H2S to achieve s

53 eophilic displacement is due to the combined nucleophilicity and relatively poor leaving group abilit

54 This is largely due to the poor nucleophilicity and resistance to chemical oxidation of

55 of glycosylations using acceptors of varying nucleophilicity and size.

56 The sensitivities to changes in solvent nucleophilicity and solvent ionizing power are very simi

57 and pH are other factors responsible for the nucleophilicity and stability of 2-Pyridinyl Thermolabil

58 ectronic properties that contribute to their nucleophilicity and stability.

59 -stabilizing group for obtaining the desired nucleophilicity and the ability to utilize the aza-ylide

60 cidation, and the relationship between amine nucleophilicity and the outcome of this reaction has bee

61 tetrafluoroborate anion, depends on both the nucleophilicity and the polarity of the solvent.

62 The relationship between nucleophilicity and the structure/environment of the nuc

63 y attributed to the different basicities (or nucleophilicities) and steric effects of the two kinds o

64 (characterized by very different basicities/nucleophilicities) and three anilines have been measured

65 a (pKa = 12.33), implying that the basicity, nucleophilicity, and amine alkylation rates of 1A and 9

66 n of components, their Hammett acidity H(0), nucleophilicity, and basicity, while using theory to cal

67 ext of the lifetime of the cation, effective nucleophilicity, and cage effects in deamination.

68 and redox stability, chemical inertness, low nucleophilicity, and high hydrophobicity, making them at

69 e CsF and KF into solution, control fluoride nucleophilicity, and provide a chiral microenvironment f

70 size, ease of synthesis, high basicity, low nucleophilicity, and, in the best cases, rapid substrate

71 Nucleophilicities are furthermore found to correlate wel

72 putational approaches to comprehend acceptor nucleophilicity are assessed.

73 Factors that control nucleophilicity are discussed.

74 that were generated to characterize solvent nucleophilicity are shown not to be correlated by measur

75 ridinamide ions exhibit significantly higher nucleophilicities as compared to established organocatal

76 formation is well correlated with enol ether nucleophilicity as described by the Mayr N scale.

77 GPP analogues with abolished or perturbed pi-nucleophilicity at the delta10 double bond (GGPP numberi

78 ess to residues unavailable with traditional nucleophilicity-based conjugation methods.

79 on atom and adjacent heteroatoms, with their nucleophilicity being the primary focus.

80 The difference in nucleophilicity between the carboxylate side chains of A

81 erms of reactivity, compound 2 exhibits poor nucleophilicity, but undergoes oxidative addition at amb

82 acid or dimedone, respectively, reduces the nucleophilicity by approximately 10 orders of magnitude.

83 ic studies showed that ring strain increases nucleophilicity by approximately 10(9).

84 indicate attenuation of zinc-bound thiolate nucleophilicity by sulfane.

85 nce to oxidation and attenuation of sulfur's nucleophilicity by the anomeric effect.

86 ding evidence for the alpha effect (enhanced nucleophilicity by the presence of a contiguous atom wit

87 ne toward a series of acetylenes of improved nucleophilicity can be described within the context of t

88 polysulfanide anions also exhibit decreased nucleophilicity compared to the parent thiolate anions.

89 Owing to their high nucleophilicity, cysteine and lysine residues are the mo

90 tronegative atoms exhibit exceptionally high nucleophilicity despite relatively low basicity.

91 -Hp, interfacial water molecules have larger nucleophilicity due to the higher interface penetration

92 ctronegativity (x), electrophilicity (w) and nucleophilicity (e).

93 c class of molecules by virtue of their dual nucleophilicity/electrophilicity.

94 ing allylboronate complexes display enhanced nucleophilicity, enabling addition to a range of electro

95 the Zn(2+) thiolate, supporting the proposed nucleophilicity enhancement of persulfides due to the al

96 es (presenting a nucleophilic hydroxyl and a nucleophilicity-enhancing hydrogen-bonding imidazole nit

97 r electrons of Ser-130 O gamma, reducing its nucleophilicity for cross-linking.

98 ination to Lewis acids affords a transfer of nucleophilicity from the carbene carbon atom to the atta

99 residue, H162G, does not eliminate cysteine nucleophilicity, further arguing against a pre-formed io

100 ceMoS(2) surface as a function of the anion nucleophilicity (i.e., charging effect).

101 low-valent nitrogen(I) species with moderate nucleophilicities in several pharmacophoric functionalit

102 Relative nucleophilicities in the photoreactions are also similar

103 ed acidity from oxidizing capacity and anion nucleophilicity in a manner not previously achieved.

104 Their nucleophilicity in a stoichiometric S(N)2 reaction and c

105 reactivity of the catalyst over the inherent nucleophilicity in an alcohol silylation reaction.

106 nt ends in recent years, from augmenting the nucleophilicity in pyramidalized low-valent p-block comp

107 lcoholates, which show enhanced basicity and nucleophilicity in the inner phase as compared to the bu

108 nic pincer-type ligand demonstrates enhanced nucleophilicity in unusually fast "Wittig-like" reaction

109 sopropylidene oxindoles (electrophilicity vs nucleophilicity) in the presence of a chiral organocatal

110 Erosion of stereoselectivity occurs as nucleophilicity increases, which is consistent with addi

111 es that analysis of the electrophilicity and nucleophilicity indices is an excellent tool for experim

112 Hence, contradicting the nucleophilicity indices of sulfur (from thiol) and nitro

113 Using Marcus theory, we separate nucleophilicity into two independent components, an intr

114 The concept of nucleophilicity is at the basis of most transformations

115 ability, and high basicity, while minimizing nucleophilicity is important for reducing unwanted side

116 s to sensitivities toward changes in solvent nucleophilicity (l) of 1.20 +/- 0.07 and toward changes

117 ide through coordination and attenuating its nucleophilicity, leading to the inhibition of the undesi

118 one hydrogen in ammonia by Me increases the nucleophilicity more than introduction of an amino group

119 les are characterized by two parameters: the nucleophilicity N and the susceptibility sN.

120 ity (pK(aH) in water and K(b) in benzene) or nucleophilicity (N Mayr constants) of the tested amines.

121 The Lewis basicity (LB) and nucleophilicity (N, s(N)) parameters of phenolates deter

122 ral amines possessing varying basicities and nucleophilicities: n-butylamine, diethylamine, triethyla

123 In this work, we have measured nucleophilicities of a series of substituted alkoxides i

124 In this work, the nucleophilicities of chloride, bromide, and iodide have

125 Because of the wide range of nucleophilicities of naturally occurring acceptors, the

126 linear correlation, we estimate the range of nucleophilicities of organic functional groups, ranging

127 on of the ionic liquid affected the relative nucleophilicities of the halides.

128 It is found that the apparent nucleophilicities of the substituted alkoxides are alway

129 nd predict its effects, the electrophilicity/nucleophilicity of >500 radicals has been calculated.

130 give sensitivities toward changes in solvent nucleophilicity of 0.42 for 1 and 0.53 for 2 and corresp

131 The global nucleophilicity of 3-amino- and 3,5-diamino-1H-1,2,4-tri

132 ive means to alter the hydrophilicity and/or nucleophilicity of a molecule.

133 K(MT) = 10 +/- 4, demonstrating the superior nucleophilicity of alpha(red) relative to Co(1+)FeSP.

134 However, the low nucleophilicity of amides means that divergent coupling

135 oxidation state of palladium catalysts, the nucleophilicity of amines, and the nature of the ligands

136 in the oncogene KRAS by overcoming the weak nucleophilicity of an acquired serine residue.

137 sed as a model system to interrogate how the nucleophilicity of an attacking organic, low-oxidation s

138 In addition, based on the superior nucleophilicity of aNHCs, relative to that of their nNHC

139 By exploiting the different nucleophilicity of aromatic and aliphatic isocyanides, w

140 ubstituents in CF(3)-pentenynes and external nucleophilicity of aromatic molecules.

141 wo main reaction pathways depend on internal nucleophilicity of aryl substituents in CF(3)-pentenynes

142 ble patient population; however, the reduced nucleophilicity of aspartate compared to cysteine poses

143 of the relationship between the basicity and nucleophilicity of bases, enriching the comprehension of

144 e of this research, it was observed that the nucleophilicity of both the aniline nitrogen and various

145 g 7-aza-Trp, which is expected to temper the nucleophilicity of C2 in Trp, is a very poor substrate.

146 he carbene center with retention of the high nucleophilicity of CAACs, and therefore CAArCs feature a

147 idation; however, in complex with nDsbD, the nucleophilicity of cDsbD increases permitting reductant

148 at neither secondary structure nor intrinsic nucleophilicity of Cys thiols was sufficient to explain

149 ction as an active site base to increase the nucleophilicity of Cys113.

150 ing selective probes for lysine are the high nucleophilicity of cysteines and poor hydrolytic stabili

151 action, leveraging the unique beta-selective nucleophilicity of deconjugate lactone in conjunction wi

152 The increase of nucleophilicity of difluorocarbene facilitates the react

153 or acetone, which indicated the exceptional nucleophilicity of DMSO.

154 In addition, the unique nucleophilicity of fluoride versus hydroxide toward VX,

155 igh toxicity associated with HF and the poor nucleophilicity of fluoride.

156 The nucleophilicity of free pyridinamide ions exceeds that o

157 The lower nucleophilicity of germanium(II) leads to contrasting re

158 computationally the formation, acidity, and nucleophilicity of glutathione persulfide (GSSH/GSS(-)),

159 en bond is obvious, in light of the enhanced nucleophilicity of GS(-) versus the protonated thiol.

160 me in the transition state that enhances the nucleophilicity of GSH.

161 n bonding to the quinone oxygen enhances the nucleophilicity of H2Sx by facilitating the removal of t

162 The nucleophilicity of HSO(4)(-) is 100x lower than SO(4)(2-

163 nucleophilic constants (Aka) to quantify the nucleophilicity of hydroxyl groups in glycosylation infl

164 nsformations occur through the control of C3 nucleophilicity of indazole moiety.

165 hydes is challenging because the significant nucleophilicity of indole leads to C-C coupling with an

166 a-methoxy riboside compound, with a relative nucleophilicity of MeOH to H2O of 11.

167 onstrate that a K(+) ion can mask the latent nucleophilicity of N2-derived nitride and imide ligands

168 ee energy relationships of k(cat) versus the nucleophilicity of N5 of FAD(red) gave a slope of rho =

169 Using the nucleophilicity of NHCs and aNHCs, as well as the leavin

170 THF triflate intermediate that triggers the nucleophilicity of nitriles (Nu(1)) and led to regiosele

171 in o-alkynylaniline derivatives due to high nucleophilicity of nitrogen has been overcome by using t

172 ion is often complicated by the basicity and nucleophilicity of nitrogen, its susceptibility to oxida

173 dimerization products was attributed to the nucleophilicity of Nu(2).

174 hes off the amide resonance and recovers the nucleophilicity of one of the nitrogen atoms.

175 is work, we show that by exploiting the high nucleophilicity of opportunely designed aminopyridines,

176 is one of the few reactions that exploit the nucleophilicity of organoaurates to a migrating acyl gro

177 The low nucleophilicity of phenols represents a major obstacle t

178 Herein, we studied the acidity and nucleophilicity of several low molecular weight persulfi

179 ifferent terminations, depending on relative nucleophilicity of species present in the liquid-phase s

180 x cysteine modifications based on the unique nucleophilicity of sulfinic acids.

181 We exploit the soft nucleophilicity of sulfur to react it with maleimide der

182 substituents on the substrates and the weak nucleophilicity of the -C(6)F(5) ligand.

183 y sample rare conformations that enhance the nucleophilicity of the 2'-hydroxyl.

184 tch-II pocket (SII-P), exploiting the strong nucleophilicity of the acquired cysteine as well as the

185 t that the mutation has little effect on the nucleophilicity of the active site Cys residue.

186 hydrogen bonds favorable for increasing the nucleophilicity of the active-site asparagine.

187 The nucleophilicity of the additives influences only the iso

188 that increases the proton acidity and oxygen nucleophilicity of the alcohol.

189 e site of the chiral thiourea to enhance the nucleophilicity of the alkene and provide transition-sta

190 OMe) on the sulfonyl aryl group enhances the nucleophilicity of the amido anion contained within the

191 t traditional alkylating methods rely on the nucleophilicity of the amine and make access to such com

192 as the positively charged ammonium salt, and nucleophilicity of the amine is important in enzyme-cata

193 llowing drug release at the tumor site), the nucleophilicity of the amine manifests itself and cycliz

194 mparing various amines, we discover that the nucleophilicity of the amine reactant is a descriptor fo

195 To date, the lack of nucleophilicity of the amines is redhibitory.

196 aturing significant steric shielding and low nucleophilicity of the amino functionality as well as st

197 The greater nucleophilicity of the amino group leads to efficient ol

198 The nucleophilicity of the anions in such compounds can be c

199 his sulfur-halogen interaction activates the nucleophilicity of the approaching SO2 and makes a norma

200 7 act as catalytic residues by enhancing the nucleophilicity of the attacking amino group of glucosam

201 tes and transition states, together with the nucleophilicity of the azide donor.

202 anism is interpreted in terms of the reduced nucleophilicity of the base in water, which disfavors th

203 lineC double bond drastically increases the nucleophilicity of the beta-carbon atom of the alkene to

204 While the nucleophilicity of the bromide ion is expected to be att

205 under mild basic conditions due to the high nucleophilicity of the C-3-OH.

206 rboxamide of AICAR is poised to increase the nucleophilicity of the C5 amine, while proton abstractio

207 with several electrophiles demonstrated the nucleophilicity of the C=C double bond, affording oxasil

208 n spite of the reverse order of basicity and nucleophilicity of the carbonyl group and the pyrrole ri

209 a Glu-His-Ser catalytic triad to enhance the nucleophilicity of the catalytic serine.

210 a Glu-His-Ser catalytic triad to enhance the nucleophilicity of the catalytic serine.

211 erminal position to overcome the decrease of nucleophilicity of the CF3-PsiPro.

212 nds involving the hydroxo ligand reduces the nucleophilicity of the CoIII-OH unit and reinforces the

213 The results indicate that the nucleophilicity of the competing functional groups, pola

214 the electrophile, and (b) the difference in nucleophilicity of the conjugate basic sites.

215 e potential to correlate these data with the nucleophilicity of the corresponding carbenes.

216 ference of NH and OH along with the reversed nucleophilicity of the corresponding conjugate bases N(-

217 between CH(3)I breakthrough uptakes and the nucleophilicity of the counter anions.

218 ributions in accordance with the anticipated nucleophilicity of the dipyrromethane and dipyrromethane

219 carbonate deprotection are dependent on the nucleophilicity of the functional group involved in the

220 a rate-limiting step primarily driven by the nucleophilicity of the heme peroxo moiety.

221 his observation is likely due to the reduced nucleophilicity of the indole nitrogen.

222 elimination of hydroxyl group controlled by nucleophilicity of the indole ring.

223 gation/association state of the ions and the nucleophilicity of the involved anions.

224 n was revealed to substantially increase the nucleophilicity of the iodoamine and lower the activatio

225 ric solvents due to the reduced basicity and nucleophilicity of the negatively charged chain ends of

226 is attributed to differences in basicity and nucleophilicity of the nitrogen atom in a common carboca

227 d from CO-induced N2 cleavage, increases the nucleophilicity of the nitrogen atom, thus promoting add

228 ex with NO, whereas in FDP(NO) the increased nucleophilicity of the nitrosyl group may promote attack

229 binding to the coenzyme, they increased the nucleophilicity of the nucleophile Cys302.

230 Presumably, reduction of the nucleophilicity of the olefin by the second, inductively

231 In this study, the nucleophilicity of the oxatriquinane oxygen was evaluate

232 Additionally, the nucleophilicity of the oxo ligands in 2 and 3 toward Me(

233 on of an iminium ion with aminocatalyst, the nucleophilicity of the phenolic hydroxy group in salicyl

234 In addition to the required nucleophilicity of the phosphanido moiety to accomplish

235 d in live RAW 264.7 cells, based on the soft nucleophilicity of the phosphine oxide functionality tow

236 ptide substrates suggests that the intrinsic nucleophilicity of the phosphoserine residue is much hig

237 rt with the catalytic Cys 214, increases the nucleophilicity of the PL 5'-OH group for the inline dis

238 I) complexes exhibiting an expressed d(z(2))-nucleophilicity of the positively charged metal centers,

239 enerally slow because of the relatively weak nucleophilicity of the primer 3'-hydroxyl.

240 catalysis mechanism had been ascribed to the nucleophilicity of the pyridine ring.

241 pyrrole C2 positions) and leverages the high nucleophilicity of the pyrrole template for the concomit

242 f the axial hydroxy group which enhances the nucleophilicity of the respective oxygen atom, permittin

243 teine, as well as a decreased enhancement of nucleophilicity of the second substrate, GSH.

244 The intensified nucleophilicity of the singlet carbene is manifested in

245 otonated 2 increasing with a decrease in the nucleophilicity of the solvent.

246 of reaction products strongly depends on the nucleophilicity of the starting arene and the electrophi

247 s to the flavin coenzyme and to increase the nucleophilicity of the substrate amine moiety.

248 Only in the cases when the nucleophilicity of the substrates exceeds that of the am

249 the solvent reactivity of CH(3) (+), the non-nucleophilicity of the sulfur atom of SO(3), and the hig

250 Soft nucleophilicity of the sulfur in Cys renders an exquisit

251 can usually be rationalized on the basis of nucleophilicity of the sulfur or polarity matching betwe

252 ffect of solvation by water molecules on the nucleophilicity of the superoxide anion, O2(*-), has bee

253 ding through changes to the relative electro/nucleophilicity of the terminal sulfido ligand accompany

254 talytic zinc tartrate is used to enhance the nucleophilicity of the thiol.

255 This suggests that expected trends in the nucleophilicity of the various metal-bound hydroxides ar

256 d provide quantitative evidence for the high nucleophilicity of these novel derivatives, setting the

257 With the advantages of the distinct nucleophilicity of thiol and hydroxyl groups, the chemis

258 We show that nucleophilicity of thiophenes, evaluated by Hammett sigm

259 f favoring productive fold and enhancing the nucleophilicity of this oxygen.

260 bserved effects of alcohol concentration and nucleophilicity on the product distribution.

261 The effect of acceptor nucleophilicity on the reaction mechanism is described a

262 el acceptors revealed the effect of acceptor nucleophilicity on the stereoselectivity of these donors

263 e, indicating no effects of this increase in nucleophilicity on transition-state structure.

264 radical orbital energy trends and resulting nucleophilicity or electrophilicity of fluorinated radic

265 titution, S(N)Ar, while intrinsic S(N)Vsigma nucleophilicity parallels aliphatic S(N)2.

266 he basicity parameter (proton affinity), the nucleophilicity parameters (N, DeltaG(AuCl), and TEP), a

267 The nucleophilicity parameters 4 < N < 8 for iodonium ylides

268 The resulting nucleophilicity parameters N (23 < N < 29) reveal the ti

269 uation, lg k(2) = s(N)(N + E), furnished the nucleophilicity parameters N (and s(N)) of the lactone e

270 uation log k(-1) = s(N)(N + E) to derive the nucleophilicity parameters N and s(N) for fluoride in va

271 rate constants k(2) of these reactions, the nucleophilicity parameters N and s(N) were determined ac

272 ve been made to theoretically predict Mayr's nucleophilicity parameters N based on calculation of mol

273 radicals through their electrophilicity and nucleophilicity parameters.

274 increasing the proton acidity and the oxygen nucleophilicity, permits donor activation and concomitan

275 Despite excellent nucleophilicity, proteolysis by IgG proceeded at lower r

276 Despite their inherently high nucleophilicity, pyrroles have rarely been explored in F

277 The boosted nucleophilicity resulting from the constrained tetracoor

278 ucleophilicity; the decrease in the apparent nucleophilicity results from a weaker thermodynamic driv

279 d according to their positions in the Mayr's nucleophilicity scale (N parameter), and three main clas

280 Furthermore, their reactivity on the Mayr nucleophilicity scale as well as their Bronsted and Lewi

281 Mayr's nucleophilicity scale likely represents the most complet

282 By localizing their position on the Mayr nucleophilicity scale, the scope of their electrophilic

283 A1-A32 were integrated in our comprehensive nucleophilicity scale, which compares n-, pai-, and sigm

284 hiles so far integrated on our comprehensive nucleophilicity scale.

285 The iodonium ylides 1(a-d) thus have nucleophilicities similar to those of pyrroles, indoles,

286 the pivotal roles of the base's basicity and nucleophilicity specifically allow us to achieve control

287 deeper insight into the solvation effect on nucleophilicity, such as the remarkably lower reactiviti

288 n binding locations and has higher desirable nucleophilicity, surprisingly limited research has been

289 consequence of both its higher basicity and nucleophilicity than TBO as well as the high reactivity

290 owing to its low natural frequency and poor nucleophilicity, the design of effective methods for bot

291 s, do not significantly affect the intrinsic nucleophilicity; the decrease in the apparent nucleophil

292 luence, but yet the phosphines manifest high nucleophilicity to coordinate strongly with W(0) and Re(

293 ents of similar ionizing power but different nucleophilicities) to compare sensitivities to nucleophi

294 tems was analyzed, and the variations in the nucleophilicity trend at the coordinating nitrogen cente

295 The nucleophilicity values are in good agreement with the si

296 The relative nucleophilicities vary somewhat with the attack site; th

297 The tendency to exhibit greater nucleophilicity vs electrophilicity can be established u

298 complex and probed differences in persulfide nucleophilicity when compared to the parent thiolate.

299 tion is intrinsically limited by the arene's nucleophilicity, which has previously restrained the app

300 In addition, GSS(-) presented higher nucleophilicity with respect to a thiolate with similar