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1 s from products of an unlinked but essential nucleoside phosphorylase.
2 it is a tight inhibitor (Kd 12 nM) of purine nucleoside phosphorylase.
3  of calf spleen and human erythrocyte purine nucleoside phosphorylase.
4  2-amino-6-mercapto-7-methylpurine by purine nucleoside phosphorylase.
5  the ribosylated metabolites by human purine nucleoside phosphorylase.
6 ated effect was dependent on the DeoD purine nucleoside phosphorylase.
7 ve NP, it was widely inferred to be a purine nucleoside phosphorylase.
8 e (dGK) or degraded in the cytosol by purine nucleoside phosphorylase.
9 nce such as nucleoside hydrolases and purine nucleoside phosphorylases.
10  catalyzed by P. falciparum and human purine nucleoside phosphorylases.
11 e monophosphate kinase, 3.2-fold; pyrimidine nucleoside phosphorylase 3.6-fold) in resistant cells.
12 ne can rescue cultured parasites from purine nucleoside phosphorylase and adenosine deaminase blockad
13 ins as transition state analogues for purine nucleoside phosphorylase and characterized them with the
14 hatase, 5'-nucleotidase cytosolic-II, purine nucleoside phosphorylase and xanthine oxidase) was perfo
15 d with a combination of adenosine deaminase, nucleoside phosphorylase and xanthine oxidase, the senso
16 urines when both human and Plasmodium purine nucleoside phosphorylases and adenosine deaminases are i
17 onversions by adenosine deaminase and purine nucleoside phosphorylase, and it displayed limited oral
18 s established that uridine hydrolase, purine nucleoside phosphorylase, and methylthioadenosine phosph
19 dditionally have adenosine deaminase, purine nucleoside phosphorylase, and S-methyl-5'-thioadenosine
20                                              Nucleoside phosphorylases are essential for the salvage
21      Human (HsPNP) and bovine (BtPNP) purine nucleoside phosphorylases are homotrimers with the catal
22           Here we show that mammalian purine nucleoside phosphorylase but not methylthioadenosine pho
23                                       Purine nucleoside phosphorylase catalyzes reversible phosphorol
24              Genetic defects in human purine nucleoside phosphorylase cause T-cell deficiency as the
25 anilate phosphoribosyltransferase (TrpD) and nucleoside phosphorylase class II enzymes but bind with
26  that uridine hydrolase and mammalian purine nucleoside phosphorylase cleave nicotinic acid riboside,
27 is measured using the pyrophosphatase-purine nucleoside phosphorylase coupling system with the chromo
28                  A mycoplasma-encoded purine nucleoside phosphorylase (designated PNPHyor) has been c
29                Chemical inhibition of purine nucleoside phosphorylase did not improve deoxyguanosine
30 ate structures of human and bovine of purine nucleoside phosphorylases differ, despite 87% homologous
31 ant to phosphorolytic cleavage by pyrimidine nucleoside phosphorylase enzymes.
32 f NT and green fluorescent protein or purine nucleoside phosphorylase form hydrogels with intact func
33                                       Purine nucleoside phosphorylase from Plasmodium falciparum (PfP
34                     Deletion of the putative nucleoside phosphorylase gene deoD resulted in an inabil
35 ated guanosine analogues catalyzed by purine nucleoside phosphorylase has been analyzed to understand
36 upstream) and two ORFs representing a purine nucleoside phosphorylase homolog and tpp15, a previously
37     Crystallographic studies of human purine nucleoside phosphorylase (hPNP) with several transition-
38 -> Glu and His(104) --> Arg) in human purine nucleoside phosphorylase (hPNP), there is an enhancement
39 mH) are picomolar inhibitors of human purine nucleoside phosphorylase (hPNP).
40                                 Human purine nucleoside phosphorylase (huPNP) is essential for human
41 s origin within the greater radiation of the nucleoside phosphorylase/hydrolase-peptide/amidohydrolas
42 uanosine, suggesting involvement of a purine nucleoside phosphorylase in the nucleoside protective ef
43  The coding sequence annotated as a putative nucleoside phosphorylase in the Trypanosoma cruzi genome
44                         Forodesine, a purine nucleoside phosphorylase inhibitor, displays in vitro ac
45 oselective synthesis of PNP405 (1), a purine nucleoside phosphorylase inhibitor, is described.
46  Treatment of cultures with BCX-34, a purine nucleoside phosphorylase inhibitor, prevented protection
47           The action of P. falciparum purine nucleoside phosphorylase is a convergent step of purine
48    The transition-state structure for purine nucleoside phosphorylase is characterized by (1) an elev
49 n of transition-state inhibitors with purine nucleoside phosphorylase is different from reactant-stat
50 ective for malarial relative to human purine nucleoside phosphorylase, kills P. falciparum in culture
51 resistance to adenosine deaminase and purine nucleoside phosphorylase mediated metabolism.
52 y and biochemically characterized a putative nucleoside phosphorylase (NP) from the pathogenic protoz
53       Phosphoribosyltransferase (PRTase) and nucleoside phosphorylase (NPase) activities were detecte
54 ts metabolism to hypoxanthine through purine nucleoside phosphorylase or its uptake into cells throug
55                 Plasmodium falciparum purine nucleoside phosphorylase (PfPNP) catalyzes an essential
56 e P. falciparum purine salvage enzyme purine nucleoside phosphorylase (PfPNP) is a potential drug tar
57 ed a strong increase of P. falciparum purine nucleoside phosphorylase (PfPNP) melting temperature by
58 rate binding site is unlike that from purine nucleoside phosphorylase, phosphoribosyltransferases, or
59        Expression of Escherichia coli purine nucleoside phosphorylase (PNP) activates prodrugs and ki
60 athway consisting of a bacterial type purine nucleoside phosphorylase (PNP) and a purine nucleoside k
61 urine salvage system, consisting of a purine nucleoside phosphorylase (PNP) and a purine nucleoside k
62 transition-state analogues for bovine purine nucleoside phosphorylase (PNP) and are the most powerful
63  deoxyguanosine (dG) or guanosine via purine nucleoside phosphorylase (PNP) and hypoxanthine-guanine
64                                       Purine nucleoside phosphorylase (PNP) and hypoxanthine-guanine
65 ensitive to a purine salvage block at purine nucleoside phosphorylase (PNP) and that human PNP is a t
66                                       Purine nucleoside phosphorylase (PNP) and xanthine oxidase (XOD
67                                 Human purine nucleoside phosphorylase (PNP) belongs to the trimeric c
68 be hydrogen-bonding interactions with purine nucleoside phosphorylase (PNP) by NMR spectroscopy.
69                                       Purine nucleoside phosphorylase (PNP) catalyzes N-ribosidic bon
70                                       Purine nucleoside phosphorylase (PNP) catalyzes the reversible
71           Genetic deficiency of human purine nucleoside phosphorylase (PNP) causes T-cell immunodefic
72 sition path sampling study with heavy purine nucleoside phosphorylase (PNP) characterized the experim
73                  The Escherichia coli purine nucleoside phosphorylase (PNP) converts purine analogs i
74 sociated protein, 70 kDa (ZAP70), and purine nucleoside phosphorylase (PNP) deficiencies had low resp
75                      The discovery of purine nucleoside phosphorylase (PNP) deficiency and T lymphocy
76                                       Purine nucleoside phosphorylase (PNP) deficiency in humans resu
77                                       Purine nucleoside phosphorylase (PNP) deficiency is a rare form
78                      Escherichia coli purine nucleoside phosphorylase (PNP) expressed in tumors conve
79                                 Human purine nucleoside phosphorylase (PNP) forms a ribocation-like t
80 meric member in the trimeric class of purine nucleoside phosphorylase (PNP) from Archaea.
81 cture of SsMTAP is similar to that of purine-nucleoside phosphorylase (PNP) from Escherichia coli, ho
82  in which the dual specificity enzyme purine nucleoside phosphorylase (PNP) functions in both purine
83 competitive inhibitors of calf spleen purine nucleoside phosphorylase (PNP) have been determined empl
84 bose 1-phosphate (R1P) bound to human purine nucleoside phosphorylase (PNP) have been studied by FTIR
85 ential inhibitors of glycosidases and purine nucleoside phosphorylase (PNP) have been synthesized via
86   Herein, we investigated the role of purine nucleoside phosphorylase (PNP) in NR metabolism in mamma
87        Forodesine is a new and potent purine nucleoside phosphorylase (PNP) inhibitor.
88                                 Human purine nucleoside phosphorylase (PNP) is a homotrimer binding t
89                                 Human purine nucleoside phosphorylase (PNP) is a homotrimer, containi
90                                       Purine nucleoside phosphorylase (PNP) is a key enzyme in the pu
91                                       Purine nucleoside phosphorylase (PNP) is a target for the devel
92                                       Purine nucleoside phosphorylase (PNP) is a well-known molecular
93                                       Purine nucleoside phosphorylase (PNP) is an important component
94                                       Purine nucleoside phosphorylase (PNP) is an important enzyme in
95                                       Purine nucleoside phosphorylase (PNP) is an important enzyme in
96                                 Human purine nucleoside phosphorylase (PNP) is highly specific for 6-
97                                       Purine nucleoside phosphorylase (PNP) is part of the human puri
98  evaluated as potential inhibitors of purine nucleoside phosphorylase (PNP) isolated from peripheral
99 bitol] is a 23 pM inhibitor of bovine purine nucleoside phosphorylase (PNP) specifically designed as
100                   Inhibition of human purine nucleoside phosphorylase (PNP) stops growth of activated
101 tate analogue inhibitors of mammalian purine nucleoside phosphorylase (PNP) that induce purine-less d
102 lso armed with the prodrug convertase purine nucleoside phosphorylase (PNP) that locally converts the
103                                 Human purine nucleoside phosphorylase (PNP) was crystallized with tra
104 The X-ray crystal structures of human purine nucleoside phosphorylase (PNP) with bound inosine or tra
105 ient and tumor-specific expression of purine nucleoside phosphorylase (PNP), an Escherichia coli enzy
106 cies of adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP), result in defective lymp
107 nzymes in its purine salvage pathway, purine nucleoside phosphorylase (PNP), shows physical propertie
108 upling at the catalytic site of human purine nucleoside phosphorylase (PNP).
109 applied to the chemical step of human purine nucleoside phosphorylase (PNP).
110 rom the metabolism of inosine by ecto-purine nucleoside phosphorylase (PNP).
111 y Immucillin H, an inhibitor of human purine nucleoside phosphorylase (PNP).
112 formation (barrier-crossing) in human purine nucleoside phosphorylase (PNP).
113 n-H (Imm-H), a picomolar inhibitor of purine nucleoside phosphorylase (PNP).
114 oduced from inosine phosphorolysis by purine nucleoside phosphorylase (PNP).
115 losis deoD gene encodes a presumptive purine nucleoside phosphorylase (PNP).
116 taxa were previously characterized as purine nucleoside phosphorylases (PNP).
117 ggests that alterations in the enzyme purine nucleoside phosphorylase (PNPase) may participate in oxi
118 that partial inhibition of the enzyme purine nucleoside phosphorylase (PNPase) with 8-aminoguanine (a
119 uanines) are inhibitors of the enzyme purine nucleoside phosphorylase (PNPase) with Ki' values rangin
120                                       Purine nucleoside phosphorylases (PNPs) and uridine phosphoryla
121   A structural genomics comparison of purine nucleoside phosphorylases (PNPs) indicated that the enzy
122  Additionally, mycoplasma-derived pyrimidine nucleoside phosphorylase (PyNP) activity indirectly pote
123                  The findings imply that the nucleoside phosphorylase superfamily 1 evolved through a
124 own of the guanosine to guanine using purine nucleoside phosphorylase, the ammonia formed as a result
125  of the transition-state structure of purine nucleoside phosphorylase were synthesized and tested as
126      This situation is reminiscent of purine nucleoside phosphorylase, which involves protonation of
127 is limitation by employing the enzyme purine nucleoside phosphorylase with substrate 7-methylguanosin
128 standing the evolution of uridine and purine nucleoside phosphorylases with respect to DNA/RNA metabo

 
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