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1 s from products of an unlinked but essential nucleoside phosphorylase.
2 it is a tight inhibitor (Kd 12 nM) of purine nucleoside phosphorylase.
3 of calf spleen and human erythrocyte purine nucleoside phosphorylase.
4 2-amino-6-mercapto-7-methylpurine by purine nucleoside phosphorylase.
5 the ribosylated metabolites by human purine nucleoside phosphorylase.
6 ated effect was dependent on the DeoD purine nucleoside phosphorylase.
7 ve NP, it was widely inferred to be a purine nucleoside phosphorylase.
8 e (dGK) or degraded in the cytosol by purine nucleoside phosphorylase.
9 nce such as nucleoside hydrolases and purine nucleoside phosphorylases.
10 catalyzed by P. falciparum and human purine nucleoside phosphorylases.
11 e monophosphate kinase, 3.2-fold; pyrimidine nucleoside phosphorylase 3.6-fold) in resistant cells.
12 ne can rescue cultured parasites from purine nucleoside phosphorylase and adenosine deaminase blockad
13 ins as transition state analogues for purine nucleoside phosphorylase and characterized them with the
14 hatase, 5'-nucleotidase cytosolic-II, purine nucleoside phosphorylase and xanthine oxidase) was perfo
15 d with a combination of adenosine deaminase, nucleoside phosphorylase and xanthine oxidase, the senso
16 urines when both human and Plasmodium purine nucleoside phosphorylases and adenosine deaminases are i
17 onversions by adenosine deaminase and purine nucleoside phosphorylase, and it displayed limited oral
18 s established that uridine hydrolase, purine nucleoside phosphorylase, and methylthioadenosine phosph
19 dditionally have adenosine deaminase, purine nucleoside phosphorylase, and S-methyl-5'-thioadenosine
25 anilate phosphoribosyltransferase (TrpD) and nucleoside phosphorylase class II enzymes but bind with
26 that uridine hydrolase and mammalian purine nucleoside phosphorylase cleave nicotinic acid riboside,
27 is measured using the pyrophosphatase-purine nucleoside phosphorylase coupling system with the chromo
30 ate structures of human and bovine of purine nucleoside phosphorylases differ, despite 87% homologous
32 f NT and green fluorescent protein or purine nucleoside phosphorylase form hydrogels with intact func
35 ated guanosine analogues catalyzed by purine nucleoside phosphorylase has been analyzed to understand
36 upstream) and two ORFs representing a purine nucleoside phosphorylase homolog and tpp15, a previously
37 Crystallographic studies of human purine nucleoside phosphorylase (hPNP) with several transition-
38 -> Glu and His(104) --> Arg) in human purine nucleoside phosphorylase (hPNP), there is an enhancement
41 s origin within the greater radiation of the nucleoside phosphorylase/hydrolase-peptide/amidohydrolas
42 uanosine, suggesting involvement of a purine nucleoside phosphorylase in the nucleoside protective ef
43 The coding sequence annotated as a putative nucleoside phosphorylase in the Trypanosoma cruzi genome
46 Treatment of cultures with BCX-34, a purine nucleoside phosphorylase inhibitor, prevented protection
48 The transition-state structure for purine nucleoside phosphorylase is characterized by (1) an elev
49 n of transition-state inhibitors with purine nucleoside phosphorylase is different from reactant-stat
50 ective for malarial relative to human purine nucleoside phosphorylase, kills P. falciparum in culture
52 y and biochemically characterized a putative nucleoside phosphorylase (NP) from the pathogenic protoz
54 ts metabolism to hypoxanthine through purine nucleoside phosphorylase or its uptake into cells throug
56 e P. falciparum purine salvage enzyme purine nucleoside phosphorylase (PfPNP) is a potential drug tar
57 ed a strong increase of P. falciparum purine nucleoside phosphorylase (PfPNP) melting temperature by
58 rate binding site is unlike that from purine nucleoside phosphorylase, phosphoribosyltransferases, or
60 athway consisting of a bacterial type purine nucleoside phosphorylase (PNP) and a purine nucleoside k
61 urine salvage system, consisting of a purine nucleoside phosphorylase (PNP) and a purine nucleoside k
62 transition-state analogues for bovine purine nucleoside phosphorylase (PNP) and are the most powerful
63 deoxyguanosine (dG) or guanosine via purine nucleoside phosphorylase (PNP) and hypoxanthine-guanine
65 ensitive to a purine salvage block at purine nucleoside phosphorylase (PNP) and that human PNP is a t
72 sition path sampling study with heavy purine nucleoside phosphorylase (PNP) characterized the experim
74 sociated protein, 70 kDa (ZAP70), and purine nucleoside phosphorylase (PNP) deficiencies had low resp
81 cture of SsMTAP is similar to that of purine-nucleoside phosphorylase (PNP) from Escherichia coli, ho
82 in which the dual specificity enzyme purine nucleoside phosphorylase (PNP) functions in both purine
83 competitive inhibitors of calf spleen purine nucleoside phosphorylase (PNP) have been determined empl
84 bose 1-phosphate (R1P) bound to human purine nucleoside phosphorylase (PNP) have been studied by FTIR
85 ential inhibitors of glycosidases and purine nucleoside phosphorylase (PNP) have been synthesized via
86 Herein, we investigated the role of purine nucleoside phosphorylase (PNP) in NR metabolism in mamma
98 evaluated as potential inhibitors of purine nucleoside phosphorylase (PNP) isolated from peripheral
99 bitol] is a 23 pM inhibitor of bovine purine nucleoside phosphorylase (PNP) specifically designed as
101 tate analogue inhibitors of mammalian purine nucleoside phosphorylase (PNP) that induce purine-less d
102 lso armed with the prodrug convertase purine nucleoside phosphorylase (PNP) that locally converts the
104 The X-ray crystal structures of human purine nucleoside phosphorylase (PNP) with bound inosine or tra
105 ient and tumor-specific expression of purine nucleoside phosphorylase (PNP), an Escherichia coli enzy
106 cies of adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP), result in defective lymp
107 nzymes in its purine salvage pathway, purine nucleoside phosphorylase (PNP), shows physical propertie
117 ggests that alterations in the enzyme purine nucleoside phosphorylase (PNPase) may participate in oxi
118 that partial inhibition of the enzyme purine nucleoside phosphorylase (PNPase) with 8-aminoguanine (a
119 uanines) are inhibitors of the enzyme purine nucleoside phosphorylase (PNPase) with Ki' values rangin
121 A structural genomics comparison of purine nucleoside phosphorylases (PNPs) indicated that the enzy
122 Additionally, mycoplasma-derived pyrimidine nucleoside phosphorylase (PyNP) activity indirectly pote
124 own of the guanosine to guanine using purine nucleoside phosphorylase, the ammonia formed as a result
125 of the transition-state structure of purine nucleoside phosphorylase were synthesized and tested as
127 is limitation by employing the enzyme purine nucleoside phosphorylase with substrate 7-methylguanosin
128 standing the evolution of uridine and purine nucleoside phosphorylases with respect to DNA/RNA metabo