ライフサイエンスコーパス: nucleosomal

1 that regulate these processes span from the nucleosomal (10-nm) to the chromosomal (>200-nm) levels,

2 nguishing feature of pioneer factors remains nucleosomal access rather than an exceptional residence

3 ting the 'arginine anchor' on CENP-C for the nucleosomal acidic patch disrupts the CENP-A nucleosome

4 nicity-enhancing immune complexes (ICs) with nucleosomal Ags during cell culture.

5 predict that integration is favoured within nucleosomal and flexible DNA, in line with experiments,

6 Our method calculates the energy of both nucleosomal and linear DNA of the given sequence.

7 fferences in how Swi6 and Chp2 interact with nucleosomal and non-nucleosomal ligands and qualitative

8 rations at steady state, including the fully nucleosomal and nucleosome-free configuration.

9 We find that cleaved forms of H3 are nucleosomal and the histone variant H3.3 is the preferre

10 e, including the maximally repressive, fully nucleosomal, and the maximally non-repressive, nucleosom

11 Nucleosomal antigens were deposited in target tissue fro

12 ranges from 1 to 10% in mammals, retains the nucleosomal architecture and is implicated to play a rol

13 ted loops suggest that HU architecture, like nucleosomal architecture, which modulates the ability of

14 omatin fiber likely through intra- and inter-nucleosomal arginine-DNA contacts to enable tighter nucl

15 Sequence analysis and nucleosomal arrangement within the region -2000 to +1000

16 oss of CTCF binding and rearrangement of the nucleosomal array around the binding motif.

17 tation velocity, atomic force microscopy and nucleosomal array capture to characterize the stoichiome

18 H3K9me2 and 3-marked nucleosomal arrays and associated complexes undergo phas

19 ucleosomal arrays in favor of non-methylated nucleosomal arrays and that nonspecific DNA interactions

20 n compaction and oligomerization assays with nucleosomal arrays containing suH4ss established that SU

21 ferentially binds histone H3K9Me3-containing nucleosomal arrays in favor of non-methylated nucleosoma

22 repositioning: Both upstream and downstream nucleosomal arrays shift toward the nucleosome-depleted

23 ectron microscopy of HP1(Hsalpha)-associated nucleosomal arrays showed that HP1(Hsalpha) caused nucle

24 ial sedimentation of HP1(Hsalpha)-associated nucleosomal arrays showed that HP1(Hsalpha) promotes int

25 studies demonstrate that self-association of nucleosomal arrays under a wide range of solution condit

26 -dependent self-association of linear 12-mer nucleosomal arrays using microscopy and physicochemical

27 This effect was recapitulated in vitro with nucleosomal arrays using unmodified histones, indicating

28 The nucleosomal arrays were packaged within the oligomers as

29 he results indicate that Sir3 interacts with nucleosomal arrays with a stoichiometry of two Sir3 mono

30 dependent eviction of Sir3p from recombinant nucleosomal arrays, and this activity enhances early ste

31 Genes are packaged into nucleosomal arrays, each nucleosome typically having two

32 chromosomal DNA, which exists in the form of nucleosomal arrays, is currently unknown.

33 site and locally organizes large and phased nucleosomal arrays, not only in interphase steady-state

34 atin proteins promote silencing by 'coating' nucleosomal arrays, stabilizing interactions between nuc

35 in remodelers can either organize or disrupt nucleosomal arrays, yet the mechanisms specifying these

36 gate, and lack of this ability in acetylated nucleosomal arrays.

37 Third, INO80 and ISW2 each align downstream nucleosomal arrays.

38 e the stoichiometry and conformation of Sir3 nucleosomal arrays.

39 resulted in a significant reduction in anti-nucleosomal autoantibodies.

40 the ability of the enzyme to recover from a nucleosomal backtrack.

41 eam of the promoter in order to overcome the nucleosomal barrier and enable PolII promoter escape, th

42 Mechanisms of nucleosomal barrier formation and nucleosome survival du

43 the molecular mechanisms of formation of the nucleosomal barrier to transcribing RNA polymerase II (P

44 The height of the nucleosomal barrier to transcription and efficiency of n

45 visiae and compare their abilities to pass a nucleosomal barrier with those of yeast Pol II and Pol I

46 rocessivity of RNA polymerase II through the nucleosomal barrier.

47 l I transcription machinery has to deal with nucleosomal barriers.

48 omatin-modifying protein high mobility group nucleosomal binding domain 2 (HMGN2) specifically promot

49 nces to identify their potential to identify nucleosomal binding sites.

50 H3/H4 tetramer, mimicking the trajectory of nucleosomal-bound DNA.

51 by histone chaperones, which handle the non-nucleosomal CenH3 pool and replenish CenH3 chromatin in

52 inal tail and the histone fold domain of non-nucleosomal CenH3.

53 and H4K12ac) primarily occur within the pre-nucleosomal CENP-A-H4-HJURP (CENP-A chaperone) complex,

54 Most nucleosomal changes are suppressed by the inhibition of

55 to reconstituted mono-, di-, tri-, and tetra-nucleosomal chromatin templates and show that key Sir-Si

56 ed sperm chromatin structures to the somatic nucleosomal chromatin.

57 300 in trans, suggesting that H3.3 acts as a nucleosomal cofactor for p300.

58 L3MBTL1 is known to regulate nucleosomal compaction, and we here showed that SGK2 ina

59 In contrast, mitotic nucleosomal complexes carrying nonphosphorylatable CENP-

60 long with core histone mapping to assess the nucleosomal configuration at enhancers and promoters in

61 However, the nucleosomal configuration of open chromatin and the basi

62 on individual "sister" histones in the same nucleosomal context, that is, asymmetric histone PTMs, a

63 Although the static structure of the nucleosomal core particle has been solved, details of th

64 eight binding sites (representing octameric nucleosomal cores) into irregularly folded clusters (lik

65 eosomal H2A-H2B cross-links as well as inter-nucleosomal cross-links.

66 Rcor2, like Rcor1, facilitates LSD1-mediated nucleosomal demethylation, Rcor3 competitively inhibits

67 how that E4orf3 indiscriminately drives high nucleosomal density of viral genomes, which is restricti

68 ctor (TF) determines histone acetylation and nucleosomal depletion commensurate with Polycomb exclusi

69 ecipher the regulatory events upstream of RI nucleosomal deposition.

70 nt of chromatin loop relaxation required for nucleosomal destabilization, and by comparative analyses

71 Consistently, nucleosomal disassembly at GAL1 is impaired in the absen

72 degrees to 70 degrees (the angle between the nucleosomal disks and the fiber axis), helical rise, dia

73 nt has indicated that the outer stretches of nucleosomal DNA "breathe" by spontaneously detaching fro

74 mploys its i-SET and c-SET domains to engage nucleosomal DNA 1 to 1.5 turns from the nucleosomal dyad

75 novel mechanism involved in processes where nucleosomal DNA accessibility is required, such as DNA r

76 CT is engaged in extensive interactions with nucleosomal DNA and all histone variants.

77 enable specific CCAN subunits to contact the nucleosomal DNA and histone subunits.

78 mised, along with decreased accessibility of nucleosomal DNA and inefficient transcription-elongation

79 actors act as pioneers; they scan and target nucleosomal DNA and initiate cooperative events that can

80 Pioneer factors such as FoxA target nucleosomal DNA and initiate cooperative interactions at

81 ver, the extent of nucleotide periodicity in nucleosomal DNA and its significance in directing nucleo

82 nucleosome interface involving both gyres of nucleosomal DNA and one H2A-H2B heterodimer.

83 jacent SHL1 and SHL2 sites, respectively, on nucleosomal DNA and pack against the DNA-binding domain

84 ation involves unravelling the outer turn of nucleosomal DNA and requires substantial reorientation o

85 SPT16 binds nucleosomal DNA and tethers H2A-H2B through its carboxy-

86 or domain loop region is positioned close to nucleosomal DNA and that the Epl1 EPcA basic region is i

87 The relay of interactions between EZH2, the nucleosomal DNA and the H3 N-terminus therefore creates

88 5 and ASH2L, which interact extensively with nucleosomal DNA and the surface close to the N-terminal

89 n, in which both bending and shearing of the nucleosomal DNA are considered.

90 The inner stretches of nucleosomal DNA are found to be more stably associated w

91 surements reveal twisting and sliding of the nucleosomal DNA arm proximal to the integration site.

92 s generated within a NCP, it is excised from nucleosomal DNA at a rate 275-1500-fold faster than that

93 CHD5 can expose nucleosomal DNA at one or two discrete positions in the

94 The ATPase motor of CHD4 binds and distorts nucleosomal DNA at superhelical location (SHL) +2, suppo

95 Moreover, SWR1 interacts preferentially with nucleosomal DNA at superhelix location 2 on the nucleoso

96 rs generally function by translocating along nucleosomal DNA at the H3-H4 interface of nucleosomes.

97 Sliding the nucleosomal DNA by approximately two base pairs along th

98 The exposure of the nucleosomal DNA by CHD5 is dependent on ATP hydrolysis,

99 ive DNA flexibility of the inner quarters of nucleosomal DNA controls the unwrapping direction such t

100 g to our simulations, the outer stretches of nucleosomal DNA detach in discrete steps involving 5 or

101 with a 15-base pair segment of the distorted nucleosomal DNA double helix, in a position predicted to

102 ature of the DNase I cleavage profile within nucleosomal DNA enables us to identify translational pos

103 Fragile nucleosomes were defined by nucleosomal DNA fragments that were recovered preferenti

104 n compaction by nucleosome stacking protects nucleosomal DNA from external forces up to 4 piconewtons

105 NA (dsDNA) that is capable of unwrapping the nucleosomal DNA from the histone octamer (HO).

106 ctors also facilitate detachment of terminal nucleosomal DNA from the histone octamer, which increase

107 ancers, indicating that asymmetric repair of nucleosomal DNA imposes a strand polarity on UV mutagene

108 The CG content of nucleosomal DNA is found to anticorrelate with the exten

109 he nucleosome in a conformation in which the nucleosomal DNA is more accessible to DNA-binding regula

110 Nucleosomal DNA is thought to be generally inaccessible

111 constraints of this arrangement suggest that nucleosomal DNA must be moved relative to the nucleosome

112 Sequencing of nucleosomal DNA obtained after MNase digestion (MNase-se

113 senting partial unwrapping and protection of nucleosomal DNA on one side of the dyad axis during chro

114 how binding of its catalytic subunit EZH2 to nucleosomal DNA orients the H3 N-terminus via an extende

115 Our data also show that shearing energy of nucleosomal DNA outperforms bending energy in nucleosome

116 Dynamics of the nucleosome and exposure of nucleosomal DNA play key roles in many nuclear processes

117 nters the barrier, the enzyme backtracks and nucleosomal DNA recoils on the octamer, locking Pol II i

118 n structure domains that allow TFs to target nucleosomal DNA remain unexplored.

119 volves the looping-and-sliding mechanism for nucleosomal DNA repositioning, bearing unexpected simila

120 emodeler binding causes perturbations in the nucleosomal DNA resulting in a bulge near the SHL2 site.

121 ome breathing, i.e., transient unwrapping of nucleosomal DNA segments.

122 stochastic dynamics were independent of the nucleosomal DNA sequence or the asymmetry created by the

123 Nucleosomal DNA sequences generally follow a well-known

124 -to-end distance of the nucleosomal DNA, the nucleosomal DNA stochastically unwraps from the histone

125 -known distribution of nucleosome occupancy: nucleosomal DNA tends to be shorter in promoters and lon

126 -Sth1 interactions, RSC engages histones and nucleosomal DNA through one arm of the core structure, c

127 ne modifications change the accessibility of nucleosomal DNA through their effects on DNA flexibility

128 ion, DNA replication, and DNA repair require nucleosomal DNA to be unwrapped so that functional prote

129 However, the accessibility of nucleosomal DNA to Cas9 is variable over several orders

130 F2 family chromatin remodeler HELLS, exposes nucleosomal DNA to designate the sites of DNA double-str

131 Pioneer factors can bind nucleosomal DNA to enable gene expression from regions o

132 e detachment of the H3 histone tail from the nucleosomal DNA to make it available for capture by the

133 ET probes placed at various positions on the nucleosomal DNA to monitor conformation of the nucleosom

134 ings imply that the spontaneous breathing of nucleosomal DNA together with the action of chromatin re

135 vercomes MNase sequence preference producing nucleosomal DNA trimmed symmetrically and precisely at t

136 e globular region of histone H4, and also to nucleosomal DNA when Piccolo NuA4 interacts with the nuc

137 e Sgf11 ZnF, but not the Sgf73 ZnF, binds to nucleosomal DNA with a binding interface composed of arg

138 ignificantly alter CPD formation, protecting nucleosomal DNA with an inward rotational setting, even

139 eletion variants, and nucleosomes containing nucleosomal DNA with different sequences and lengths, as

140 A acts on DNA within a single nucleosome, on nucleosomal DNA within adjacent nucleosomes, and DNA not

141 caused by differential accessibility of the nucleosomal DNA, a consequence of its left-handed wrappi

142 xin, to cellular DNA results in uncoiling of nucleosomal DNA, accumulation of negative supercoiling a

143 ce the accessibility of H3 tails in NCP, the nucleosomal DNA, and the linker between readers in modul

144 the relatively slow-repairing 3' side of the nucleosomal DNA, particularly at positions where the DNA

145 ctions of the core histone tail domains with nucleosomal DNA, redirecting the tails to more interior

146 that for a given end-to-end distance of the nucleosomal DNA, the nucleosomal DNA stochastically unwr

147 Nucleosomal DNA, the predominant form of plasma cfDNA, c

148 cial ability to engage their target sites on nucleosomal DNA, thus behaving as "pioneer factors" to i

149 Since p53 can bind nucleosomal DNA, we sought to understand if the two grou

150 the super helical location 2 (SHL 2) of the nucleosomal DNA, with the N-terminal tail of H4 and with

151 engaging with both Cse4 residues and AT-rich nucleosomal DNA.

152 d upon crossbridging CENP-A and its adjacent nucleosomal DNA.

153 l oscillations of the HO with respect to the nucleosomal DNA.

154 contacts between the H1 globular domain and nucleosomal DNA.

155 lay essential biological roles by mobilizing nucleosomal DNA.

156 m binding to its cognate DNA site within the nucleosomal DNA.

157 bias for incorporation of short patches into nucleosomal DNA.

158 ation of histone-DNA interaction sites along nucleosomal DNA.

159 cidic patch of the histone H2A-H2B dimer and nucleosomal DNA.

160 leosomes and the accessory subunit Ioc3 with nucleosomal DNA.

161 he sequence-dependent anisotropic bending of nucleosomal DNA.

162 rol accessibility of DNA-binding proteins to nucleosomal DNA.

163 es, but it remains unclear how TP53 binds to nucleosomal DNA.

164 higher affinity site through recognition of nucleosomal DNA.

165 of UV damage occurring on the 5' side of the nucleosomal DNA.

166 lized by electrostatic interactions with the nucleosomal DNA.

167 complexes that increase the accessibility of nucleosomal DNA.

168 tion 2 (SHL2), where the Chd1 ATPase engages nucleosomal DNA.

169 utilize DNase I cuts both outside and within nucleosomal DNA; the oscillatory nature of the DNase I c

170 gage nucleosomal DNA 1 to 1.5 turns from the nucleosomal dyad and in doing so, it positions the SET d

171 rrelates with binding sites located near the nucleosomal dyad axis.

172 gene bodies, stopping instead around the +1 nucleosomal dyad-associated region.

173 one octamer serves as a crucial regulator of nucleosomal dynamics distinct from the histone code read

174 We identify miR-93 as a regulator of nucleosomal dynamics in podocytes.

175 Conversely, upregulation of Chd1 restores nucleosomal dynamics, promotes normal induction of prote

176 are yield methods because they score either nucleosomal (e.g., MNase-seq, chemical cleavage-seq) or

177 the promoter chromatin landscape, leading to nucleosomal encroachment over the canonical TSS.

178 e-specific TFs by collaboratively binding to nucleosomal enhancers and recruiting the SWI/SNF (BAF) c

179 inding lobes poised to bind their respective nucleosomal epitopes.

180 conserved protein domains that interact with nucleosomal features.

181 ae, and use this distinctive two-dimensional nucleosomal "fingerprint" as the basis for a new nucleos

182 tone variants include cenH3, which forms the nucleosomal foundation for the centromere, and H3.3, whi

183 iven histone exchange reaction that replaces nucleosomal H2A with H2A.Z.

184 iting the histone variant H2A.Z by replacing nucleosomal H2A with H2A.Z.

185 he nucleosome acidic patch, generating intra-nucleosomal H2A-H2B cross-links as well as inter-nucleos

186 n remodeling enzymes catalyze replacement of nucleosomal H2A.Z with H2A when the substrate contains H

187 a remodeler previously reported to displace nucleosomal H2A.Z.

188 ) containing minimal components required for nucleosomal H3K4 methylation activity.

189 Biochemical assays confirm that nucleosomal H3K4me3 stimulates the histone acetyltransfe

190 e interaction module enables KDM2A to decode nucleosomal H3K9me3 modification in addition to CpG meth

191 exogenous H4-tail peptide or deletion of the nucleosomal H4 tail also diminishes the linker-length se

192 SAHA increased the extent of acetylation of nucleosomal H4K5 and H3 to re-activate adipogenic genes

193 f the Epl1 EPcA domain as necessary for this nucleosomal HAT activity.

194 We show that tryptase truncates nucleosomal histone 3 and histone 2B (H2B) and that its

195 essive complex 1 (PRC1), which ubiquitylates nucleosomal histone H2A Lys 119 using its E3 ubiquitin l

196 thin the alpha2 helix in the histone-fold of nucleosomal histone H2A, a region not previously known t

197 e-specific demethylase 1 (LSD1) demethylates nucleosomal histone H3 lysine 4 (H3K4) residues in colla

198 ically, we present mechanistic insights into nucleosomal histone H3 modification reactions in cis and

199 nalyses point to the critical roles of intra-nucleosomal histone-DNA interactions that reduce the acc

200 ontrolled posttranslational modifications of nucleosomal histones alter chromatin condensation to reg

201 mal arrays, stabilizing interactions between nucleosomal histones and DNA.

202 Turnover and exchange of nucleosomal histones and their variants, a process long

203 Nucleosomal histones are barriers to the DNA repair proc

204 during mammalian spermiogenesis, 90% of the nucleosomal histones are replaced by testis-specific tra

205 tested the hypothesis that deacetylation of nucleosomal histones associated with aberrant recruitmen

206 p) with diminished E3 ligase activity toward nucleosomal histones, despite tighter binding to unmodif

207 o be recruited to chromatin and to acetylate nucleosomal histones.

208 y reacts with free histones rather than with nucleosomal histones.

209 nt reduction in class-switched IgG, and anti-nucleosomal IgG-secreting B cells compared with B6.Sle1

210 Solid-state nanopore analyses show it to be nucleosomal in size.

211 linking cGAS and the acidic patch alleviates nucleosomal inhibition.

212 may be explained by different modes of inter-nucleosomal interactions for active and inactive chromat

213 The core histone tail domains mediate inter-nucleosomal interactions that direct folding and condens

214 il domains stabilize array folding via inter-nucleosomal interactions with the DNA of neighboring nuc

215 did not increase observance of H4-DNA inter-nucleosomal interactions.

216 kinetics of DNA re-wrapping and stabilized a nucleosomal intermediate with partially unwrapped DNA be

217 inding dynamics, and highlight how unwrapped nucleosomal intermediates provide a novel signature of a

218 g complex and RSC-bound, partially unwrapped nucleosomal intermediates.

219 ng an appreciation of the forces shaping the nucleosomal landscape in eukaryotes key to fully underst

220 As a result, the nucleosomal landscape is largely re-established before n

221 g of nucleosomes we inferred dynamics of the nucleosomal landscape.

222 Nucleosomal landscapes in ESC enhancers are extensively

223 instances the binding of a BER factor to one nucleosomal lesion appeared to facilitate binding to the

224 anding of the readout of histone PTMs at the nucleosomal level.

225 6 and Chp2 interact with nucleosomal and non-nucleosomal ligands and qualitative differences in how t

226 me remodeler biases methylation toward inter-nucleosomal linker DNA in Arabidopsis thaliana and mouse

227 ytic activity are sensitive to the length of nucleosomal linker in a nonlinear fashion.

228 and GC-containing dinucleotides (SS) in the nucleosomal locations where DNA is bent in the minor and

229 both ends of a wrapped, approximately 90-bp nucleosomal loop of DNA, suggesting a means for nucleoso

230 ased screening of histone H4 residues in the nucleosomal LRS (loss of ribosomal DNA-silencing) domain

231 MLL3/4 and histone H4 is required for their nucleosomal methylation activity and MLL4-mediated neuro

232 in regions of computationally predicted high nucleosomal occupancy, suggesting that nucleosomes are g

233 tes, but the fundamental question of whether nucleosomal or naked DNA is the preferred substrate of p

234 al start sites are nevertheless bound by non-nucleosomal or subnucleosomal histone variants (H3.3 and

235 oteins, likely contributing to regulation of nucleosomal organization and gene expression.

236 ducible TFs do not suffice to overrule basal nucleosomal organization maintained by lineage-determini

237 al gene expression by modifying its genome's nucleosomal organization via cooperation between E1A and

238 omal arginine-DNA contacts to enable tighter nucleosomal packing.

239 n the histone octamer and DNA in forming the nucleosomal particle.

240 ntly associated LSD1-CoREST to semisynthetic nucleosomal particles.

241 , micrococcal nuclease-sensitive ("fragile") nucleosomal particles.

242 at profiles of healthy individuals reflected nucleosomal patterns of white blood cells, whereas patie

243 through chromatin, and suggested that strong nucleosomal pausing guarantees efficient nucleosome surv

244 dy shows that mammalian ISWI is critical for nucleosomal periodicity and nuclear organization and tha

245 ed symmetrical and transcription-independent nucleosomal phasing across active, poised, and inactive

246 Loss of SNF2H decreases nucleosomal phasing and increases linker lengths, provid

247 Using the dwell times of Pol II at each nucleosomal position we extract the energetics of the ba

248 ic silencing of the FXN promoter via altered nucleosomal positioning and reduced chromatin accessibil

249 se within the SWI/SNF complex that regulates nucleosomal positioning.

250 s TP53 binding for TFBSs located at the same nucleosomal positions; otherwise, nucleosome position ta

251 and localizes contact domain boundaries with nucleosomal precision.

252 at 24 h post-KSHV reactivation and that the nucleosomal redistributions are widespread and transient

253 To clarify the role of DNA sequence in these nucleosomal redistributions, we compared the genes with

254 d the changes in pausing behavior within the nucleosomal region allow us to determine a drift coeffic

255 anism, namely the dynamic exposure of buried nucleosomal regions.

256 to changes in expression of genes related to nucleosomal regulation of transcription, T cell differen

257 Mi-2/nucleosomal remodeling and deacetylase (NuRD) complexes

258 served that during mouse rod maturation, the nucleosomal repeat length increases from 190 bp at postn

259 Locally, it alters the nucleosomal response, and acts as a brake on chromatin r

260 -Ser10-histone H3, an important component of nucleosomal response.

261 ied feature patterns could be used to assist nucleosomal sequence prediction.

262 use of the limited range of correlations in nucleosomal sequence preferences to create a computation

263 We find that only a small fraction of nucleosomal sequences contain significant 10.5-bp period

264 e previously observed periodicity in aligned nucleosomal sequences mainly results from proper phasing

265 ces mainly results from proper phasing among nucleosomal sequences, and not from a preponderant occur

266 o quantify the extent of acetylation at each nucleosomal site.

267 l reprogramming requires stable binding to a nucleosomal site; activation domain-dependent recruitmen

268 with well-defined coordination at different nucleosomal sites featuring DNA translocation toward the

269 eb1 and Cbf1 are significantly slower at the nucleosomal sites relative to those for naked DNA, demon

270 vivo evidence for an ISWI function in ruling nucleosomal spacing in mammals.

271 emodelers enhance Rpd3S activity by altering nucleosomal spacing, suggesting that chromatin remodeler

272 cture is generated, but with increased inter-nucleosomal spacing.

273 esolve these problems by spike-in of defined nucleosomal standards within a ChIP procedure.

274 ated manner, generating several intermediate nucleosomal states as it breaks and then reforms histone

275 0 serves to modulate the energy landscape of nucleosomal states.

276 egularly folded clusters (like those seen in nucleosomal strings).

277 Intricate control of nucleosomal structure and assembly governs access of RNA

278 Maintenance of nucleosomal structure in the cell nuclei is essential fo

279 ndent chromatin remodeler that maintains the nucleosomal structure of chromatin, but the determinants

280 of the structural constraints imposed by the nucleosomal structure, integrase gains access to the sci

281 on and transcription, and repair or regulate nucleosomal structure.

282 The compaction of nucleosomal structures creates a barrier for DNA-binding

283 The packaging of DNA into nucleosomal structures limits access for templated proce

284 ive system that has not evolved to deal with nucleosomal structures: Escherichia coli.

285 tant for enzymatic reactions/transactions on nucleosomal substrate and the formation of multiple comp

286 This layered liquid recruits Rad6 and the nucleosomal substrate, which accelerates the ubiquitinat

287 s stimulated by two defining features of the nucleosomal substrate: a basic patch on the histone H4 N

288 are also critical for Rpd3S to recognize its nucleosomal substrates and functionin vivo.

289 D is essential for histone H3 acetylation in nucleosomal substrates.

290 nd leads to a repositioning of hDot1L on the nucleosomal surface, which likely places the active site

291 ng that most of the sites are exposed on the nucleosomal surface.

292 ar and efficient, it can be used to generate nucleosomal systems in which nucleosome composition diff

293 processes ideally would be carried out with nucleosomal templates that are assembled with customized

294 nd Pol III, but not Pol II, could transcribe nucleosomal templates.

295 emodeling enzymes stimulate Cas9 activity on nucleosomal templates.

296 is shown to arise from an interplay between nucleosomal transitions into states with crossed and ope

297 a reveal that Set1 and Jhd2 together control nucleosomal turnover and occupancy during transcriptiona

298 lies an untested conjecture, namely that the nucleosomal variation arises de novo or intrinsically (i

299 re unequally conducive to transcription, the nucleosomal variation of promoter molecules may constitu

300 folding and unfolding kinetics of the outer nucleosomal wrap.