ライフサイエンスコーパス: nucleosome

1 espite the highly conserved structure of the nucleosome.

2 1 CTD serves as a nexus for signaling in the nucleosome.

3 imulated by H2B-Ub, bound to a ubiquitinated nucleosome.

4 module to bind one face of an ubiquitinated nucleosome.

5 of the LSD1/CoREST complex bound to a 191-bp nucleosome.

6 contacts of the H4 tail with a neighbouring nucleosome.

7 nucleosomes; wherein two pentamers bind to a nucleosome.

8 ption initiation/repair factor TFIIH in this nucleosome.

9 biquitinate H2B in gene bodies beyond the +1 nucleosome.

10 for subsequent deposition in the centromeric nucleosome.

11 SOX2 and its close homologue SOX11 bound to nucleosomes.

12 genes), known to harbor partially-unwrapped nucleosomes.

13 ners alter material properties of individual nucleosomes.

14 of previously deposited H3/H3.3-placeholder nucleosomes.

15 omprehensively assess how proteins recognize nucleosomes.

16 e specialized to remodel partially-unwrapped nucleosomes.

17 -molecule nanoindentation of histone variant nucleosomes.

18 sine 4 and lysine 36 of Histone H3 in nearby nucleosomes.

19 Delta mutant, particularly in the downstream nucleosomes.

20 strongly bind to a randomly chosen 0.05% of nucleosomes.

21 ting access of regulatory factors to DNA and nucleosomes.

22 vidence that PRC2 can bridge pairs of distal nucleosomes.

23 cle phases when genomic DNA is packaged into nucleosomes.

24 ichment of histone variant CENP-A-containing nucleosomes.

25 cs affect transcription through TSS-proximal nucleosomes.

26 d on stable inheritance of CENP-A containing nucleosomes.

27 se that harbor a high fraction of stacked di-nucleosomes.

28 ghly methylated cytosines relative to phased nucleosomes.

29 ng by recognizing their DNA binding sites on nucleosomes.

30 are marked by centromere protein A (CENP-A) nucleosomes.

31 pecific regulation and transcription through nucleosomes.

32 an intrinsic capacity to transcribe through nucleosomes.

33 sociation with core histone proteins to form nucleosomes.

34 of resident H3 nucleosomes with CENP-A(Cnp1) nucleosomes.

35 ew the few structural studies on native-like nucleosomes.

36 ns to manage and remodel partially-unwrapped nucleosomes.

37 meres via interacting with H4 to form stable nucleosomes.

38 H4K16ac forms large domains that control nucleosome accessibility of promoters prior to ZGA in fl

39 a conserved interaction between Sth1 and the nucleosome acidic patch enhances remodeling.

40 's chromatin associated motif (ChAM) and the nucleosome acidic patch region, which in 53BP1-expressin

41 n addition to their evolutionarily conserved nucleosome acidic patch, we identify the positively char

42 ses two conserved arginines to anchor to the nucleosome acidic patch.

43 zle and show that although at low densities, nucleosomes act as barriers to cohesin diffusion, beyond

44 Here, we use nucleosome affinity proteomics with a library of nucleos

45 altering the structure of damage containing-nucleosomes, allowing access to BER enzymes.

46 have proven powerful in the investigation of nucleosome and chromatin fiber dynamics.

47 me, recognizing ubiquitin on one face of the nucleosome and methylating H3 on the opposing face.

48 s a chromatin enzyme (LSD1) to function on a nucleosome and not just histones, we have determined the

49 motifs that are exposed on the surface of a nucleosome and thus access silent genes that are inacces

50 bility measurements, observe single-molecule nucleosome and transcription factor protection footprint

51 arrangements to cement interactions with the nucleosome and with ubiquitin.

52 tones are epigenetic regulators that bind to nucleosomes and alter chromatin structures and dynamics.

53 by evolutionarily conserved, well-positioned nucleosomes and are frequently dysregulated in cancer.

54 ics of chromatin at the level of both single nucleosomes and arrays of nucleosomes folded into 3-dime

55 Linker histone H1 proteins bind to nucleosomes and facilitate chromatin compaction(1), alth

56 analyses, that MeCP2 directly interacts with nucleosomes and its genomic distribution correlates with

57 determinants of H2A.Z occupancy at specific nucleosomes and its relationship to transcription initia

58 anscripts is accompanied by changes at genic nucleosomes and Pol II redistribution.

59 lytic subunit Isw1 with the acidic pocket of nucleosomes and the accessory subunit Ioc3 with nucleoso

60 ic tissue-specific promoters lack positioned nucleosomes and this signal, have wide nucleosome-deplet

61 and physics-based data associated with DNA, nucleosomes, and chromatin.

62 cleosome, on nucleosomal DNA within adjacent nucleosomes, and DNA not associated with the DNMT3A-nucl

63 influence the packing density, clustering of nucleosomes, and the width of the chromatin fiber.

64 xacerbate nephritis while extinguishing anti-nucleosome antibodies, whereas Tlr9 deficiency in dendri

65 rmolecular contacts between NSD proteins and nucleosomes are altered by several recurrent cancer-asso

66 Nucleosomes are incorporated into DNA loops during compa

67 Consequently, nucleosomes are involved in essential genomic transactio

68 the mutational mechanisms affected by strong nucleosomes are low-fidelity replication, insufficient m

69 a 20-kb silent heterochromatic domain where nucleosomes are methylated at histone H3K9.

70 at the dynamics of both canonical and CENP-A nucleosomes are preserved and partitioned across the nuc

71 Nucleosomes are refractory to TF binding, and often must

72 east Reb1 and Tbf1, and a tightly positioned nucleosome, are strong blocks to the strand displacement

73 one tails enables a large variation of inter-nucleosome arrangements, disorder within the chromatin-b

74 c domains are complex structures composed of nucleosome arrays that are bound by silencing factors.

75 The pentameric domain assists nucleosome assembly and forms a discrete complex with pr

76 the activity of Scm3(HJURP), the centromeric nucleosome assembly factor.

77 -dependent remodelers, that are recruited to nucleosomes at defined locations and modulate their stru

78 3K4me3 chromatin profile and hyperacetylated nucleosomes at transcription start sites establish a chr

79 ochastic removal and reformation of promoter nucleosomes, at a distance from equilibrium.

80 DNA synthesis, the efficient disruption of a nucleosome barrier by Pif1 could lead to the futile re-r

81 with in vitro measurements suggest that the nucleosome barrier to TF binding is modulated by dynamic

82 ocessivity factor that helps Pol II across a nucleosome barrier.

83 esearch provides molecular insights into the nucleosome-based recognition and histone-modification me

84 by a self-templating feedback loop based on nucleosomes bearing the histone H3 variant CENP-A.

85 Nonspecific DNA and nucleosome binding accounted for most of the low mobilit

86 Mutations of cGAS that disrupt nucleosome binding alter cGAS-mediated signalling in cel

87 ility chromatin domains, whereas weak or non-nucleosome binding factors are excluded from the domains

88 ss of acidic patch binding and whether other nucleosome binding hot-spots exist remain unclear.

89 escribe a functional interplay between a key nucleosome binding hub and a histone modification that u

90 py we observe that both histone variants and nucleosome binding partners alter material properties of

91 important disorder-to-order transition upon nucleosome binding: it forms a helix that enhances its D

92 The nucleosome-binding interface exclusively occupies the st

93 t DNA replication through either a Reb1 or a nucleosome block occurs only in the presence of the 5'-3

94 nit and subunit-nucleosome interfaces in the nucleosome-bound conformation.

95 hat condensin complexes can readily act upon nucleosome-bound DNA molecules.

96 rotein, Hmo1, to remodel partially-unwrapped nucleosomes, but show differential reliance on these fac

97 ermine whether the kinases search for target nucleosomes by primarily moving in three dimensions thro

98 ic features that discriminate CENP-A from H3 nucleosomes by revealing that DNA end flexibility can be

99 on elongation factors that facilitate Pol II nucleosome bypass without hydrolyzing ATP.

100 local nucleosome positioning by limiting how nucleosomes can be packed between NDRs.

101 Our results suggest that nucleosomes can facilitate termination by serving as a b

102 In order to unravel the mechanisms by which nucleosomes can influence, or be altered by, DNA-binding

103 Pioneer transcription factors, which bind nucleosomes, can access the low-mobility chromatin domai

104 Nucleosomes cluster together when chromatin folds in the

105 ters act together to produce different-sized nucleosome clutches.

106 eosome core particles, in which a 2:1 enzyme:nucleosome complex assembles via asymmetric binding with

107 omes, and DNA not associated with the DNMT3A-nucleosome complex.

108 Probing different structures of Oct4-nucleosome complexes, we show that alternative configura

109 tion of end-to-end distance) upon binding to nucleosomes, consistent with a transition to an ordered

110 ed of CTCF or cohesin, whereas disruption of nucleosome contacts alters their structural organization

111 romatin, we must determine the structures of nucleosomes containing native DNA sequences.

112 based on the crystallographic studies of the nucleosomes containing non-native DNA sequences.

113 SINEs) are preferentially overrepresented in nucleosome-containing boundaries.

114 standing how molecular interactions with the nucleosome contribute to the chromatin-opening phenomeno

115 ucleosomal DNA must be moved relative to the nucleosome core for de novo methylation to occur.

116 vious crystallographic studies of the CENP-A nucleosome core particle (NCP) reconstituted with a huma

117 lly inactive accessory subunit DNMT3B3 and a nucleosome core particle flanked by linker DNA.

118 tructure of Homo sapiens CHD4 engaged with a nucleosome core particle in the presence of the non-hydr

119 oscopy structure of cGAS in complex with the nucleosome core particle.

120 uisitely tight interaction between SIRT6 and nucleosome core particles, in which a 2:1 enzyme:nucleos

121 ory DNMT3B3 binds to the acidic patch of the nucleosome core, which orients the binding of DNMT3A2 to

122 ctedly positioned 100 angstrom away from the nucleosome core.

123 ly reduces the expression of genes with wide nucleosome-deficient regions (e.g., ribosomal protein ge

124 Biochemical experiments with model nucleosomes demonstrate sufficiently stable transcriptio

125 sibility occur without significant change in nucleosome density and represent key features of AgR loc

126 ltering the distance between heterochromatic nucleosome-depleted regions (NDRs), which is predicted t

127 s and remodels the +1 nucleosome to generate nucleosome-depleted regions during gene activation(9).

128 r INO80, which explains how INO80 can define nucleosome-depleted regions in the absence of other fact

129 regions of unusually low bendability within nucleosome-depleted regions upstream of transcription st

130 ioned nucleosomes and this signal, have wide nucleosome-depleted regions, and are more enriched for c

131 After nucleosome deposition at each round of rDNA replication,

132 acent surfaces are the primary hot-spots for nucleosome disk interactions, whereas nearly half of the

133 s have suggested that an acidic patch on the nucleosome disk may be a common site for recruitment to

134 isk interactions, whereas nearly half of the nucleosome disk participates only minimally in protein b

135 for packaging of newly synthetized DNA into nucleosomes during the S phase when their expression is

136 omains of all three H1 isoforms bound to the nucleosome dyad.

137 Nucleosome dynamics and properties are central to all fo

138 Understanding the effects of nucleosome dynamics on the chromatin fiber, primarily th

139 ibitory state that is relieved by binding to nucleosomes, enabling dimethylation of histone H3 at Lys

140 ine changes in BAF complex architecture upon nucleosome engagement and compare the structural model o

141 Defects in nucleosome eviction in ino80Delta cells are frequently a

142 We also show that nucleosome eviction occurs bidirectionally over a large

143 with both histone and DNA components of the nucleosome, explaining its essential function in demethy

144 Nucleosome flexibility and the amplitude of nucleosome m

145 vel of both single nucleosomes and arrays of nucleosomes folded into 3-dimensional shapes.

146 poration, which reflects the need to remodel nucleosomes following base excision by DNA glycosylases

147 A and DAXX may fortuitously result in hybrid nucleosome formation.

148 The length of nucleosome free regions (NFRs) profoundly affects clutch

149 However, even in nucleosome-free regions, chromosomes are highly decorate

150 T-induced indels occur disproportionately in nucleosome-free regions, suggesting that much HT-induced

151 tuations to determine the Young's modulus of nucleosomes from all-atom molecular dynamics simulations

152 ied human canonical BAF complex bound to the nucleosome, generated using cryoelectron microscopy (cry

153 Because passage of Pol II through +1 nucleosomes genome-wide would obligate H2A.Z turnover, w

154 BAF complexes bilaterally engage the nucleosome H2A/H2B acidic patch regions through the SMAR

155 Here, we report that the heterotypic nucleosome has an intermediate elasticity (8.5 +/- 0.5 M

156 ding of the beads-on-a-string arrangement of nucleosomes has been built largely on high-resolution se

157 Although nucleosomes have been reported to regulate mRNA polyaden

158 gesting that the complex may target multiple nucleosomes implying a processive deacetylase function.

159 ical for TC-NER downstream of the first (+1) nucleosome in gene coding regions.

160 r of stem cell pluripotency, binds to DNA in nucleosomes in a sequence-specific manner.

161 roteins cause a decrease of H2A.Z-containing nucleosomes in Arabidopsis under standard growing condit

162 Nucleosomes in eukaryotes act as platforms for the dynam

163 Depletion of strong nucleosomes in older transposons suggests frequent posit

164 Furthermore, FACT maintains nucleosomes in subtelomeric regions, which is crucial fo

165 t domains to efficient Pol I passage through nucleosomes in the context of transcription rate and pro

166 Recent studies with reconstituted nucleosomes in vitro and chromatin binding in vivo revea

167 lanine inhibits H3K27 methylation by PRC2 on nucleosomes in vitro.

168 ces are often used to reconstitute arrays of nucleosomes in vitro.

169 In yeast, nucleosomes inhibit nucleotide excision repair (NER) of

170 ucleosome surface requirements of nearly 300 nucleosome interacting proteins implicated in diverse nu

171 ate sufficiently stable transcription factor-nucleosome interaction to empower cryo-electron microsco

172 While studies of individual nucleosome interactions have suggested that an acidic pa

173 unted for most of the low mobility of strong nucleosome interactor FOXA1.

174 that disrupt BAF subunit-subunit and subunit-nucleosome interfaces in the nucleosome-bound conformati

175 ion start site (TSS)-proximal half of the +1 nucleosome is largely independent of Rad26, likely due t

176 Genome packaging by nucleosomes is a hallmark of eukaryotes.

177 air data to show that repair of UV damage in nucleosomes is asymmetric.

178 Significantly, eviction of the more distant nucleosomes is dependent upon the FACT histone chaperone

179 ages two nucleosomes separated by one spacer nucleosome, is a preferred low-energy configuration.

180 ous promoter-proximal pausing and downstream nucleosome location.

181 Nucleosome flexibility and the amplitude of nucleosome motions such as breathing and twisting are en

182 taining complex remodels partially-unwrapped nucleosomes much better than does the Rsc2-containing co

183 Indeed, in addition to the well-known nucleosomes Nuc0, Nuc1, and Nuc2 loaded on integrated HI

184 Additionally, we defined a specific nucleosome/nucleosome-depleted region structure that res

185 We examine global nucleosome occupancy and gene expression in 2CLCs and id

186 We performed nanopore sequencing of nucleosome occupancy and methylome (nanoNOMe) on four hu

187 hanges in chromatin openness in concert with nucleosome occupancy and placement of histone modificati

188 ciency of using single pA sites, and control nucleosome occupancy around pA sites.

189 REC8 associates with regions of high nucleosome occupancy in multiple chromatin states, inclu

190 complex to regulate histone acetylation and nucleosome occupancy in the beta-globin locus control re

191 eam of a gene with a sequence that increases nucleosome occupancy in vivo reduced readthrough transcr

192 namic changes in the chromatin state such as nucleosome occupancy influence the cold-induced AS remai

193 Our results show that characteristic nucleosome occupancy levels are strongly associated with

194 ription overlapping gene bodies, and reduced nucleosome occupancy particularly at the 3' ends of gene

195 yses suggest that Hap2-Ino80 destabilizes H3 nucleosomes on centromere DNA through transcription-coup

196 here that DNMT3A acts on DNA within a single nucleosome, on nucleosomal DNA within adjacent nucleosom

197 ndent stimulation of DNA synthesis through a nucleosome or Reb1 barrier is prevented.

198 identified histones, both free and bound to nucleosomes or neutrophil extracellular traps, as Clec2d

199 remodelers that directly engage and remodel nucleosomes or transcription elongation factors that fac

200 ides a powerful new methodology for studying nucleosome organization at a previously intractable reso

201 with bare DNA, mononucleosomes, and adjacent nucleosome pairs, our data also provide direct evidence

202 Likewise, nucleosome patterns differ between exitrons and retained

203 The core nucleosome performs a fundamental regulatory role, apart

204 Furthermore, conditions that caused poor nucleosome positioning also led to defects in both heter

205 -transcriptionally, and specific patterns of nucleosome positioning and chromatin modifications corre

206 the patterns of epigenetic modifications and nucleosome positioning are established around promoters

207 s (NDRs), which is predicted to affect local nucleosome positioning by limiting how nucleosomes can b

208 Epigenetic features and nucleosome positioning contribute to the accessibility o

209 pause location, strongly suggestive of a +1 nucleosome positioning element.

210 our data show that characteristic changes in nucleosome positioning modulate AS in plants in response

211 le and efficient means to generate arrays of nucleosome positioning motifs, and facilitate a high deg

212 d restoration of chromatin accessibility and nucleosome positioning near transcription start sites, a

213 Epigenetic modifications and nucleosome positioning play an important role in modulat

214 These inhibit active nucleosome positioning required to maintain open transcr

215 DNA molecules containing a defined series of nucleosome positioning sequences are often used to recon

216 Our model shows that heterogeneous nucleosome positioning, and the resulting position-depen

217 l H2A.Z accumulation coincides with improved nucleosome positioning, heightened transcription factor

218 information such as chromatin accessibility, nucleosome positioning, histone tail modifications and e

219 ip between inter-NDR distance and defects in nucleosome positioning.

220 Z histone variant, H3K4me3 modification, and nucleosome positioning.

221 in-remodeling enzymes control accessibility, nucleosome positioning/occupancy, and nuclear organizati

222 addition, Micro-C provides a detailed map of nucleosome positions and localizes contact domain bounda

223 ing to natively and nondestructively measure nucleosome positions on individual chromatin fibres.

224 The organization of genomic DNA into nucleosomes profoundly affects all DNA-related processes

225 of the human DNA molecules are wrapped into nucleosomes, protein spools with DNA.

226 Some ANAs bind DNA or associated nucleosome proteins, whereas other ANAs bind protein com

227 mes are preserved and partitioned across the nucleosome pseudodyad.

228 rses the SER3 promoter and elicits occlusive nucleosome rearrangements.

229 rmediate subnucleosomal states and promoting nucleosome reassembly.

230 ure shows that COMPASS spans the face of the nucleosome, recognizing ubiquitin on one face of the nuc

231 like domain that mediates recruitment of the nucleosome remodeler Brg1 and FUS-assisted liquid-liquid

232 The loss of nucleosome remodeler INO80-C did the opposite.

233 ltransferase (KMT1/SUV39), and components of nucleosome remodeling and deacetylase (NuRD) are part of

234 ociated protein 2 (MTA2), a component of the nucleosome remodeling and deacetylase complex (NuRD).

235 ETO2 recruits the NuRD nucleosome remodeling and deacetylation complex to regul

236 ors of transcription by interacting with the nucleosome remodeling and histone deacetylase complexes.

237 y large allosteric changes that activate the nucleosome remodeling and spacing activities of ISW1a wh

238 show that alternative isoforms of the DOMINO nucleosome remodeling ATPase, DOM-A and DOM-B, directly

239 equently enable other transcription factors, nucleosome remodeling complexes, and histone modifiers t

240 tly improve DNA translocation efficiency and nucleosome remodeling in vitro.

241 ed in genes encoding subunits of the SWI/SNF nucleosome-remodeling and SAGA chromatin-modifying compl

242 ALC1/CHD1L is a nucleosome-remodeling enzyme that responds to DNA damage

243 the transcription machinery-as well as with nucleosome remodellers and histone deacetylases-at activ

244 Furthermore, the nucleosome repeat length defined the spatial unit of met

245 boundaries prevents supercoil diffusion and nucleosome repositioning at coding regions.

246 , Micro-C, to map chromosome architecture at nucleosome resolution in human ESCs and fibroblasts.

247 at CST can organize ssDNA analogously to the nucleosome's organization of double-stranded DNA.

248 -3" bridging mode, in which PRC2 engages two nucleosomes separated by one spacer nucleosome, is a pre

249 The distribution of somatic mutations in nucleosomes shows the opposite asymmetry in NER-proficie

250 es because of a subtle interplay between the nucleosome size and the mean linker length.

251 Low bendability of linker DNA inhibits nucleosome sliding into the linker by the chromatin remo

252 omatin characteristics including compaction, nucleosome spacing, transcription regulation, and the re

253 n parameter by studying systems with regular nucleosome spacing; second, we design systems with natur

254 iants influence chromatin properties such as nucleosome stability and the local chromatin environment

255 ositioning is incompatible with higher-order nucleosome stacking, which involves contacts of the H4 t

256 Within nucleosomes, stiff DNA sequences confer spontaneous part

257 al that pioneer factors can directly perturb nucleosome structure and chromatin accessibility in diff

258 tone deacetylation, critical for maintaining nucleosome structure and regulating gene expression, is

259 n in DNA methylation control, PTM crosstalk, nucleosome structure, and phase separation.

260 major grooves without significant changes in nucleosome structure.

261 l issues related to the determination of the nucleosome structures and review the few structural stud

262 However, to date, our knowledge of nucleosome structures is mainly based on the crystallogr

263 est how the holo-NuRD might assemble on a di-nucleosome substrate.

264 but requires the CoREST repressor to act on nucleosome substrates.

265 ning its essential function in demethylating nucleosome substrates.

266 ins substantial H3K4 demethylase activity on nucleosome substrates.

267 f RNAPII accumulation overlapped with the +1 nucleosome, suggesting that upon inhibition of RNA cleav

268 zation of H2A.Z almost exclusively at the +1 nucleosome suggests that a transcription-initiation depe

269 Our screen defines nucleosome surface requirements of nearly 300 nucleosome

270 nd summarizes areas of interactions with the nucleosome that allow remodeling to occur.

271 ntegrated HIV-1 DNA, we also found NucDHS, a nucleosome that covers the DNase hypersensitive site, in

272 o study the biophysical properties of hybrid nucleosomes that are known to exist in human cancer cell

273 eosome affinity proteomics with a library of nucleosomes that disrupts all exposed histone surfaces t

274 Here, we reveal the structural dynamics of nucleosomes that mediate Oct4 binding from molecular dyn

275 uture structural studies of some native-like nucleosomes that play critical roles in chromatin functi

276 Downstream of the +1 nucleosome, the combination of low TFIIH occupancy and h

277 on when ISW1a is bound to either mono- or di-nucleosomes, there are major differences in the interact

278 rve the DNA of an ensemble of such breathing nucleosomes through x-ray diffraction with contrast matc

279 te electrostatic interaction utilized by the nucleosome to direct RNF168 orientation towards the targ

280 r how SWI/SNF recognizes and remodels the +1 nucleosome to generate nucleosome-depleted regions durin

281 ng these length scales, from the 10 nm sized nucleosome to mitotic chromosomes, whilst jostling withi

282 Binding of a nucleosome to SAGA displaces the HAT and DUB modules fro

283 nteract with the acidic patch of neighboring nucleosomes to drive short-range compaction of chromatin

284 , such as S. cerevisiae RSC, slide and eject nucleosomes to regulate transcription.

285 that mediates bridging contacts between the nucleosome, ubiquitin and COMPASS.

286 t cellular localization and enhanced H3K9me3-nucleosome ubiquitylation activity.

287 tial affinity to repressed, H2AK119Ub-marked nucleosomes, underlying the selective targeting to polyc

288 We reveal that, although nucleosomes unwrap at ~20 pN, histones (at least histone

289 ion with fluorescence microscopy, to monitor nucleosome unwrapping and histone localisation as a func

290 arrier to TF binding is modulated by dynamic nucleosome unwrapping governed by ATP-dependent chromati

291 cules associate with the acidic patch on the nucleosome, we find that the intrinsically disordered SI

292 Chromosome-wide, nucleosomes were characterized by high DNA bendability n

293 bind their target 5'-GAT-3' sequences in the nucleosome when they are located in solvent accessible,

294 and forms a discrete complex with pre-formed nucleosomes; wherein two pentamers bind to a nucleosome.

295 ukaryotes, DNA wraps around histones to form nucleosomes, which are compacted into chromatin.

296 over, driving the replacement of resident H3 nucleosomes with CENP-A(Cnp1) nucleosomes.

297 The association of nucleosomes with most genomic DNA prevents initiation fr

298 ch as breathing and twisting are enhanced in nucleosomes with multiple TF binding sites.

299 asing the remodeler-actin interaction toward nucleosomes with the non-canonical histone H2A.Z, thereb

300 Specialized pioneer TFs bind nucleosome-wrapped DNA to perform this chromatin opening