ライフサイエンスコーパス: nucleotide

1 thereby impacts the identity of the incoming nucleotide.

2 methylation on the ribose of the penultimate nucleotide.

3 rporation by PrimPol is dependent on the n-1 nucleotide.

4 crobes, and dephosphorylates proinflammatory nucleotides.

5 A interactions spanning tens of thousands of nucleotides.

6 for high-affinity binding of the initiating nucleotides.

7 linked to specific genes and even individual nucleotides.

8 larger features such as entire residues and nucleotides.

9 ds on different substrates, including cyclic nucleotides.

10 widely from 5,386 ( X174) to 6,067 (alpha3) nucleotides.

11 Of the human genome, 144.4 million nucleotides (4.7%) are occupied by polytracts, and 0.47

12 Each duplication started at nucleotide 991, creating an additional DNA substrate for

13 interactions with flipped non-template (NT) nucleotides "AAGT" at -4 to -1 positions of the DNA prom

14 6-fold increase in phosphorylated adenosine nucleotide abundance.

15 phils, shown previously to allow transfer of nucleotides across membranes.

16 closing and opening typically occurs in each nucleotide addition cycle in transcription elongation.

17 tial-transcription pausing can occur in each nucleotide addition during initial transcription, partic

18 long templates, and this has shown that RdRp nucleotide addition kinetics is stochastically interrupt

19 xible element of the active site involved in nucleotide addition, can stimulate translesion RNA synth

20 transcription, particularly the first 4 to 5 nucleotide additions.

21 otation from the RefSeq is mapped based on a nucleotide alignment of the full sequence to a covarianc

22 translating long error-prone reads from the nucleotide alphabet into the alphabet of repeat units.

23 of assembling centromeres from reads (in the nucleotide alphabet) into a more tractable problem of as

24 f the conjugated DNA was varied from 5 to 30 nucleotides, altering the zeta potential of the detectio

25 ent 'levels' of viral genome representation: nucleotide, amino acid, amino acid properties and protei

26 PC population dynamics has mostly relied on nucleotide analog incorporation that does not label quie

27 Polymerases are commonly targeted by nucleotide analog inhibitors for the treatments of vario

28 We show that, in difference to resistance to nucleotide analogs, which is mainly associated with few

29 ession; indeed, alterations in extracellular nucleotide and adenosine signalling determine outcomes o

30 NA that modulates the position of the coding nucleotide and thereby impacts the identity of the incom

31 soforms in their productive interaction with nucleotides and filamentous actin.

32 een data achieving the accuracy of 85.6% for nucleotide- and 91.3% for heme-binding pockets.

33 upied by polytracts, and 0.47 million single nucleotides are identified as polytract hinges, i.e., br

34 athogenesis, providing examples of how these nucleotides are involved in regulating many aspects of v

35 We further found that, while incorrect nucleotides are quickly rejected, they nonetheless stabi

36 Moreover, these Z nucleotides are shown to also activate the nonrelated re

37 is study underscores the selection of ribose nucleotides as second messengers and finds its roots in

38 arboring addition or deletion of one or more nucleotides at the 5' and/or 3' ends of the canonical mi

39 d over 100 CVB3 clones harboring nine unique nucleotide "barcodes." Using this collection of barcoded

40 g and mutational analyses, we identified the nucleotide bases in the occluding mRNA 3'UTR that intera

41 ore than 16 perfectly alternating 3' U and G nucleotides become gene-silencing agents.

42 ures of genome folding, revealing effects of nucleotides beyond the core CTCF motif.

43 trate without perturbing the equilibrium for nucleotide binding at physiological Mg(2+) concentration

44 etween multiple binding events in the cyclic nucleotide binding domains of HCN pacemaker channel.

45 which depends on a conserved cysteine in its nucleotide binding site (C20).

46 ion with a citrate of crystallization at the nucleotide binding site and exhibits structural features

47 simultaneously measured channel currents and nucleotide binding to Kir6.2.

48 alized, ordered, hydrated, and available for nucleotide binding.

49 ber of the higher eukaryotes and prokaryotes nucleotide-binding (HEPN) domain-containing nuclease fam

50 Plant nucleotide-binding (NB) leucine-rich repeat (LRR) recept

51 ting is mediated by the intracellular cyclic nucleotide-binding domain (CNBD) connected to the pore-f

52 e-causing mutations located within the first nucleotide-binding domain (NBD1) of the cystic fibrosis

53 Pm5e encodes a nucleotide-binding domain leucine-rich-repeat-containing

54 tion of EGFR, protease-activated receptor 2, nucleotide-binding domain, leucine-rich-containing famil

55 Here we identify epigenetic regulation of nucleotide-binding leucine rich repeat or Nod-Like Recep

56 d that narrowed the Ptr1 candidates to eight nucleotide-binding leucine-rich repeat protein (NLR)-enc

57 s, including a detailed multi-genome-derived nucleotide-binding leucine-rich repeat protein repertoir

58 ptides) activate innate immune cells through nucleotide-binding oligomerization domain (NOD) 1 and/or

59 atory effects of the innate immune molecule, nucleotide-binding oligomerization domain-like receptors

60 insights into the dynamic process of guanine nucleotide-binding protein (G-protein) activation.

61 se that communication between the actin- and nucleotide-binding regions of myosin assures a proper ac

62 couples structural changes in the actin- and nucleotide-binding regions with force generation.

63 rived from WEW, which encodes a coiled-coil, nucleotide-binding site and leucine-rich repeat protein

64 plants, on top of existing phytohormone and nucleotide-binding-leucine-rich-repeat (NLR) networks, t

65 th proteins involved in inhibition of purine nucleotide biosynthesis and with GTPases that control ri

66 BAP1 mutant UM cells utilize glycolytic and nucleotide biosynthesis pathways, whereas OXPHOS(low) BA

67 a stem containing a precisely located single-nucleotide bulge and a GNRA tetraloop.

68 al responses could be identified for several nucleotides by 1-dimensional (1D) imino (1)H NMR as well

69 nal functionalities, ranging from individual nucleotide changes that increase efficiency of on-target

70 ffer by an additional 31 noncoding or silent nucleotide changes.

71 carry sequences that match enhancer boundary nucleotide composition.

72 ergoes a conformational change at the higher nucleotide concentration, which allows DnaA oligomerizat

73 ast kinesin-8, Kip3, under varying loads and nucleotide conditions using high-precision optical tweez

74 ctors, compartmentalized signaling of cyclic nucleotides confers specificity to extracellular stimuli

75 variants; and a model that includes extended nucleotide contexts (e.g. surrounding 3 bases on either

76 that can load structures with over 1 million nucleotides, create videos from simulation trajectories,

77 tive site compared with other zinc-dependent nucleotide deaminases.

78 The structures explain the nucleotide dependence of mHsp60 ring formation, and reve

79 Ras superfamily of small GTPases are guanine-nucleotide-dependent switches essential for numerous cel

80 ction, and it has been suggested that purine nucleotide depletion, or accumulation of other toxic pur

81 The average number of pairwise nucleotide differences among the whole genomes was found

82 moter-proximal pause (PPP) sites located ~60 nucleotides downstream of the transcriptional start site

83 ific driver gene mutations, such as the four-nucleotide duplication in the oncogene nucleophosmin (NP

84 the prebiotic formation of the components of nucleotides-either via the synthesis of ribose and the c

85 domain of one chain of P is bound near the L nucleotide entry site.

86 iro[4,4]nonane nucleus to target the guanine nucleotide exchange activity of DOCK5, which is essentia

87 rent classes and either stimulate or inhibit nucleotide exchange depending on the G-protein subtype.

88 aluated the structure and stability, guanine nucleotide exchange factor (GEF) and GTPase-activating p

89 ly, expression of a single gene, Rap guanine nucleotide exchange factor 3 (Rapgef3), was strongly up-

90 GBF1 encodes a guanine-nucleotide exchange factor that facilitates the activati

91 RET technique enables the linking of guanine nucleotide exchange factor-induced Eu(3+)-GTP associatio

92 es can generate patterns by coupling guanine nucleotide exchange factors (GEF) to effectors, generati

93 The synaptic Ras homologous (Rho) guanine nucleotide exchange factors (GEFs) Kalirin and Trio have

94 the RAS interaction with activating guanine nucleotide exchange factors (GEFs) or receptor tyrosine

95 s, are controlled by 145 multidomain guanine nucleotide exchange factors (RhoGEFs) and GTPase-activat

96 d ligation assay, BioID, to identify guanine nucleotide exchange factors that activate Cdc42 in immor

97 Upon growth factor stimulation, the guanine-nucleotide exchange modulator dissociates Galphai*betaga

98 tion observed for Galpha(i), DAPLE inhibited nucleotide exchange on Galpha(s) and Galpha(q) These fin

99 ts that would engage eIF2alpha during active nucleotide exchange, thereby discouraging both binding e

100 inding to Galpha(s) and Galpha(q) Unlike the nucleotide-exchange acceleration observed for Galpha(i),

101 eferentially bound to HSPA1L, and the Hsp110 nucleotide-exchange factor HSPH2 preferred HSPA1A.

102 Nucleotide excision repair (NER) in eukaryotes is orches

103 Nucleotide excision repair (NER) is a major DNA repair p

104 In yeast, nucleosomes inhibit nucleotide excision repair (NER) of the nontranscribed s

105 Transcription-coupled nucleotide excision repair (TC-NER) is an important DNA

106 duct DDB2 (damaged DNA binding protein 2), a nucleotide excision repair protein, is upregulated by hy

107 roles in cells including an association with nucleotide excision repair, base excision repair, mismat

108 In nucleotide excision repair, bulky DNA lesions such as UV

109 brief primer on the biological synthesis of nucleotides, followed by an extensive focus on the prebi

110 nly amino acids, but sugars, fatty acids and nucleotides for biosynthesis, conferring resistance to t

111 e present a crystal structure of BchL in the nucleotide-free form where a conserved, flexible region

112 y specifically engaging motor domains in the nucleotide-free or ADP states.

113 molecular dynamics simulations on EMB in its nucleotide-free state and a derivative homology model co

114 ha beta sheet and switch II to stabilize the nucleotide-free state of Galpha.

115 gh an unusual set of contacts that displaces nucleotide from the kinase active site.

116 s implicate both Brugia osm-9 and the cyclic nucleotide-gated (CNG) channel subunit tax-4 in larval c

117 s of both hyperpolarization-activated cyclic nucleotide-gated (HCN) and small conductance calcium-act

118 r the hyperpolarization-activated and cyclic nucleotide-gated channel HCN2 in the family of so-called

119 posed for hyperpolarization-activated cyclic nucleotide-gated channels(5), and may represent an unexp

120 The alarmone nucleotides guanosine tetraphosphate and pentaphosphate,

121 Support for chemically modified residues and nucleotides has been significantly improved along with t

122 structural features in the enzyme, such as a nucleotide hydrolysis site or multiple intermediate conf

123 rpoB sequences from cultured specimens (99% nucleotide identity cutoff).

124 entification using 16S rRNA gene and average nucleotide identity, 2) determination of virulence facto

125 dividual genomes based on reciprocal average nucleotide identity, we refer to groups circumscribed in

126 ses with sequences that shared 98-100% HIV-1 nucleotide identity.

127 ing step in the de novo synthesis of guanine nucleotides, impacting the cellular pools of GMP, GDP an

128 g often model the targeting probability of a nucleotide in a motif-based fashion, assuming that the s

129 s technique which allows the addition of one nucleotide in a one-pot reaction of sequential coupling,

130 ds or n-grams in language, or amino acids or nucleotides in bioinformatics, are generally represented

131 e CRISPR system, which also generates cyclic nucleotides in response to viral infection.

132 The importance of different nucleotides in the 5' stem-loop is revealed by mutagenes

133 nsive investigation of the importance of NTR nucleotides in the context of the entire nairovirus repl

134 TNA sequences with a preference for C and G nucleotides in the immediately flanking 5' and 3' region

135 Modified nucleotides in tRNA are critical components of the trans

136 ound to a lesion, has a strong commitment to nucleotide incorporation and thus repair.

137 Moreover, we found that following nucleotide incorporation, Rev1 converts the pyrophosphat

138 a coli RNAP without altering the fidelity of nucleotide incorporation.

139 established that cooperative binding between nucleotides inside a CA hexamer cavity results in energe

140 The origin of nucleotides is a major question in origins-of-life resea

141 and modified pentaphosphorylated magic spot nucleotides is generated in a highly efficient way.

142 Akita learns predictive nucleotide-level features of genome folding, revealing e

143 Genome-wide annotations revealed 1,516 nucleotide-level variations at different positions throu

144 ation, and S phase progression upon limiting nucleotide levels.

145 ccuracy by 25 to 70% in homopolymers up to 9 nucleotides long.

146 ein-coding transcripts that are at least 200 nucleotides long.

147 The additional three nucleotides may protect the inhibitor from excision by t

148 s largely a function of being intractable to nucleotide-mediated excision compared with similar nucle

149 Long intergenic non-coding RNA-Nucleotide Metabolism Regulator (lincNMR) is a long non-

150 mechanisms that regulate mRNA fate, covalent nucleotide modification has emerged as a major way of co

151 cytosines (m(5) C) is a post-transcriptional nucleotide modification of RNA found in all kingdoms of

152 ms a key step of de novo characterization of nucleotide modifications, shedding light on the interpre

153 steric gating and regulation of CN-gated and nucleotide-modulated channels and CNG channel-related ch

154 SthK, a cyclic nucleotide-modulated ion channel from Spirochaeta thermo

155 e departure, through the mobile arch, of the nucleotide monophosphate product from the catalytic site

156 ated in diet bioassay, which showed a single nucleotide mutation can have a significant impact or abo

157 G-I signaling less effective, whereas single nucleotide mutation of m(6)A consensus motif of viral RN

158 f non-standard mutation types, such as tetra-nucleotide mutation types.

159 form to build and test every possible single nucleotide mutation within the PTC-ring, A-loop and P-lo

160 are useful markers in cancer studies, single-nucleotide mutations are equally important, both in canc

161 The ability to identify single-nucleotide mutations is critical for probing cell biolog

162 DNA gaps greater than 1 nucleotide (nt) pose an architectural and logistical pro

163 DNA binding correlates with nucleotide occupancy: five MCM subunits are bound to eit

164 ome the limitations of introducing modifying nucleotides, often required to derive phasing informatio

165 bacteriophages, and bacterial DNA/RNA hybrid nucleotide oligomers.

166 We describe the effects of nucleotides on the assembly of a catalytically competent

167 polymerases that have evolved to incorporate nucleotides opposite DNA lesions.

168 ivery is based on the premise that 5'-and 3'-nucleotide overhangs negate Cas9/sgRNA catalytic activit

169 ing protein DksA, together with the alarmone nucleotides (p)ppGpp, mediates the stringent response to

170 heterogeneity requires the production of the nucleotides (p)ppGpp, which we show are sufficient to in

171 ively small size that recognizes a novel two-nucleotide PAM sequence.

172 found that a prevalent nonsynonymous single-nucleotide polymorphism (C/T, rs2034310) of the human CD

173 ne microsatellite markers and > 9,000 single nucleotide polymorphism (SNP) markers generated using th

174 ort suggested that the rs73185306 C/T single-nucleotide polymorphism (SNP) represents a favorable pre

175 The G allele of the lead risk single nucleotide polymorphism (SNP) rs67180937 was associated

176 We further calculated the single-nucleotide polymorphism (SNP)-based heritability of 12 s

177 ogy has made it practical to estimate single-nucleotide polymorphism (SNP)-heritability among distant

178 encing coverage to detect significant single nucleotide polymorphism (SNP)-trait associations, which

179 However, higher 52-single nucleotide polymorphism AMD genetic risk score was not a

180 , addresses this issue by aggregating single nucleotide polymorphism associations to nearest genes.

181 Single nucleotide polymorphism data were produced from a restri

182 nce among individuals, and decomposes single-nucleotide polymorphism effects as either additive, part

183 Patients were genotyped for rs4680, a single nucleotide polymorphism of COMT, and randomly allocated

184 Recent evidence associates a single nucleotide polymorphism rs174547 within the FADS1 gene,

185 entified optimal prediction with a 44 single-nucleotide polymorphism score and cutoff at the 30th per

186 f Yp pagP gene sequences identified a single-nucleotide polymorphism that results in a premature stop

187 e the first node is one specific SNP (Single Nucleotide Polymorphism) variant and the end is disease

188 ioid receptor gene, notably the A118G single nucleotide polymorphism, have been linked to individual

189 We developed a polygenic single nucleotide polymorphism-based predictor of LV mass in 7,

190 y, which may be due to non-synonymous single nucleotide polymorphisms (nsSNPs) within the AT1R gene.

191 continuous evolution with over 10,000 single nucleotide polymorphisms (SNP) variants in many subtypes

192 351,824 Single-Nucleotide Polymorphisms (SNPs) and 38 imputed Human Leu

193 tested the hypothesis that individual single nucleotide polymorphisms (SNPs) and gene-level variants

194 The functional genes or single nucleotide polymorphisms (SNPs) are not obvious due to l

195 ion studies (GWAS) have identified 14 single nucleotide polymorphisms (SNPs) associated with cutaneou

196 INVENT) consortium to examine whether single nucleotide polymorphisms (SNPs) associated with GDF-15 l

197 Many single nucleotide polymorphisms (SNPs) associated with type 2 d

198 iagnosis of FMD were genotyped for 18 single-nucleotide polymorphisms (SNPs) from 14 candidate genes.

199 We assessed germline single-nucleotide polymorphisms (SNPs) in 180 mCRC patients (An

200 Single nucleotide polymorphisms (SNPs) in Apolipoprotein E (APO

201 mated the age of more than 45 million single-nucleotide polymorphisms (SNPs) in the human genome and

202 technology allow for the detection of single-nucleotide polymorphisms (SNPs) in the pathogen genomes

203 on their parental inbred lines using single nucleotide polymorphisms (SNPs) markers obtained via gen

204 etary adherence were genotyped for 95 single nucleotide polymorphisms (SNPs) related to energy homeos

205 s and quality control, association of single nucleotide polymorphisms (SNPs) with log-transformed FGF

206 distinct positional distributions of single-nucleotide polymorphisms (SNPs) within and outside essen

207 ssociation studies (GWAS) to identify single nucleotide polymorphisms (SNPs), associated with agronom

208 netic basis, including 1) deleterious single-nucleotide polymorphisms (SNPs), in-frame indels, and de

209 e the genomic distance was 5 or fewer single-nucleotide polymorphisms (SNPs), whereas reinfection wit

210 We genotyped 21 single-nucleotide polymorphisms associated with atrial fibrilla

211 otein binding, it has been shown that single nucleotide polymorphisms can affect RNA secondary struct

212 dary structure, and here we show that single nucleotide polymorphisms can affect RNA-protein interact

213 ross-validation summaries out to 1000 single-nucleotide polymorphisms identified optimal prediction w

214 Six correlated single nucleotide polymorphisms located in a brain-expressed li

215 Genotypes of 33 single nucleotide polymorphisms previously assigned to the comp

216 cific PCR targeting outbreak-specific single nucleotide polymorphisms was applied to 290 isolates, wh

217 Similarly, the presence of FcyR single nucleotide polymorphisms was unimpactful.

218 repeats, large repeat sequences, and single nucleotide polymorphisms were identified, which are valu

219 Up to 94 single-nucleotide polymorphisms were used as instrumental varia

220 Loci were identified as clusters of single nucleotide polymorphisms where frequencies of the polymo

221 Studies regarding the association of single nucleotide polymorphisms with AVNFH, transcriptomics, pr

222 ng insulin, comprising 65, 43, and 13 single nucleotide polymorphisms, respectively.

223 Single-nucleotide polymorphisms-dense regions support a hypothe

224 h trait was associated with different single nucleotide polymorphisms.

225 ociation studies using 1000-G imputed single-nucleotide polymorphisms.

226 does not cause ECM, differ in only 21 single nucleotide polymorphysims (SNPs).

227 equired for ROS buildup and oxidation of the nucleotide pool.

228 though the impact of these contributions on nucleotide pools depends on the degree to which the memb

229 conditions that require expansion of guanine nucleotide pools.

230 guide-complementary DNA and RNA with single nucleotide precision, greatly increasing the fractions o

231 o post-transcriptional changes of individual nucleotides-remains under-appreciated.

232 We found di-nucleotide repeat motif were more frequent (4684) within

233 T3-regulated RNAs and their binding sites at nucleotide resolution in intact colorectal cancer (CRC)

234 We developed a nucleotide resolution transcriptome-wide, single molecul

235 i-BLESS labels DSBs with single-nucleotide resolution, allows detection of ultrarare bre

236 ide quantitative mapping of ac(4)C at single-nucleotide resolution.

237 ' ends of individual RNA molecules at single-nucleotide resolution.

238 d DSBs in mouse spermatocytes genome-wide at nucleotide resolution.

239 inting CodY-binding sites at close to single-nucleotide resolution.

240 ases able to resolve melt curves with single-nucleotide resolution.

241 tituents attached to the 5'- and 3'-terminal nucleotides, respectively, provided insight into the ori

242 For nucleotide reverse transcriptase inhibitor DRMs, sensiti

243 These findings uncover differences in nucleotide salvage and de novo biosynthesis using a hist

244 bacteria resist antibiotic lethality through nucleotide sanitization by MutTs, and in the absence of

245 ) enzymes are immune sensors that synthesize nucleotide second messengers and initiate antiviral resp

246 ella and gliding Mycoplasma We observed high nucleotide selectivity for ATP driving motor rotation, n

247 lls) express several TLRs, including TLR3, a nucleotide sensing receptor that recognizes double-stran

248 "cap-snatching," where IAV snatches a short nucleotide sequence from capped host RNA.

249 of model outcome, in addition to the actual nucleotide sequence of the guide DNA strand.

250 system is based on the analysis of the input nucleotide sequence using models built from curated RefS

251 was found to be 788.690 with a diversity in nucleotide sequences (0.04889 +/- S.D. 0.00468) and hapl

252 Importantly, four motifs of conserved nucleotide sequences (CNSs) were also determined, which

253 annotations, different transcript isoforms, nucleotide sequences and protein information, including

254 We retrieved 687, 667, 101 and 248 nucleotide sequences of HCV NS3 genotypes 1a, 1b, 2b, an

255 of infected hosts for enriching metadata in nucleotide sequences repositories like National Center o

256 us to assemble their complete amino acid and nucleotide sequences.

257 and cytosine-adenine (CA) repeats in IFNG by nucleotide sequencing in 647 patients with CL caused by

258 d by the three partners of the International Nucleotides Sequencing Database Collaboration (INSDC) (C

259 electrostatic interactions to finely control nucleotide signaling.

260 indings highlight the crucial role of cyclic nucleotide signalling in the conflict between viruses an

261 transmission may arise from impaired cyclic nucleotide signalling, resulting from compromised phosph

262 scripts are processed by DICER-LIKE3 into 24-nucleotide small interfering RNAs (siRNAs) that guide RN

263 regulated by actin-binding proteins, but the nucleotide state of actin is also an important factor.

264 zed to be controlled by the conformation and nucleotide state of tubulin dimers within the microtubul

265 We show that neutral evolution and nucleotide substitution rates up to forty-fold faster th

266 Simple sequence-based methods to detect nucleotide substitution variants have error rates (about

267 Cytosine base editors (CBEs) generate C-to-T nucleotide substitutions in genomic target sites without

268 Although nucleotide substitutions in the transcription apparatus

269 ses with respect to cellular levels of their nucleotide substrates.

270 p60 ring formation, and reveal an inter-ring nucleotide symmetry consistent with the absence of negat

271 p, including DNA replication, transcription, nucleotide synthesis, ribosome biogenesis and function,

272 sion decreases NADP production, PPP flux and nucleotide synthesis, while decreasing invasion in cell

273 Causal variants were enriched at conserved nucleotides, tended to have low derived allele frequency

274 e, we describe the synthesis of a photocaged nucleotide that releases guanosine within microseconds u

275 -rich stretches of generally several hundred nucleotides that are often associated with housekeeping

276 primarily through detection of extracellular nucleotides that are released by dying or infected cells

277 frequently contain tandem repeats of guanine nucleotides that can form stacked structures stabilized

278 li's 1C-metabolism, reduces the provision of nucleotides to the host, and exacerbates DNA toxicity an

279 Proteomics screening identified adenine nucleotide translocase 3 (ANT3) as a previously unknown

280 Reactive oxygen species (ROS) oxidize nucleotide triphosphate pools (e.g., 8-oxodGTP), which m

281 tRNAs universally carry a CCA nucleotide triplet at their 3'-ends.

282 pe exhibits a triplet involving the unpaired nucleotide U40 and the base pair A43-U66 in the GAUC/GAU

283 RNP consisting of two core components: a ~60-nucleotide U7 snRNA and a ring of seven proteins, with L

284 ADMs can model dependencies between adjacent nucleotides, unlike PPMs.

285 re called individually instead of as a multi-nucleotide variants (MNV).

286 mplification (n = 20), FGFR2 or FGFR3 single-nucleotide variants (n = 19), or FGFR1 or FGFR3 fusions

287 ope chiefly to address this issue for single nucleotide variants (SNVs) and insertions/deletions (ind

288 Somatic mosaicism, manifesting as single nucleotide variants (SNVs), mobile element insertions, a

289 different alteration types, including single-nucleotide variants (SNVs), small insertions and deletio

290 comparison of a fixed number of core single nucleotide variants alone cannot be used to infer cross-

291 However, the causal nature of single-nucleotide variants and small insertions and deletions i

292 Analysis of single nucleotide variants and their expression in single cells

293 Fifteen and one single-nucleotide variants for resting Tpe and Tpe response to

294 Globally, there is an enrichment of single nucleotide variants in active binding sites for TEAD4 (P

295 Williams-Beuren syndrome (WBS), while single nucleotide variants in ELN cause nonsyndromic supravalva

296 and 55 were independent BP-associated single-nucleotide variants within known BP-associated regions.

297 g sites and reactivity differences at single-nucleotide variants.

298 t trios were interrogated for de novo single-nucleotide variants/indels (dnSNVs/indels) and de novo c

299 We observed that, when a purine nucleotide was in the first coding position, DNA synthes

300 nctions as novel chain-terminating antiviral nucleotide when misincorporated by viral RNA-dependent R