ライフサイエンスコーパス: nucleotide excision repair

1 adducts which could influence the ability of nucleotide excision repair.

2 d plays essential roles in transcription and nucleotide excision repair.

3 oside and camptothecin, suggesting a role in nucleotide excision repair.

4 fficient substrate for transcription-coupled nucleotide excision repair.

5 Mutational burden increased with impaired nucleotide excision repair.

6 pair proteins that reduced the efficiency of nucleotide excision repair.

7 known for its role in transcription-coupled nucleotide excision repair.

8 ysis suggests may result from less-effective nucleotide excision repair.

9 on of genes encoding molecules important for nucleotide excision repair.

10 compromises DNA break rejoining and base and nucleotide excision repair.

11 volved in the initial steps of global genome nucleotide excision repair.

12 nylation but were nevertheless inhibitory to nucleotide excision repair.

13 are the primary initiators of global genome nucleotide excision repair.

14 on in addition to its well-known function in nucleotide excision repair.

15 Rad14p is a DNA damage recognition factor in nucleotide excision repair.

16 the unwinding of a damaged DNA duplex during nucleotide excision repair.

17 tial fate of excised oligonucleotides during nucleotide excision repair.

18 ted the importance of the targeted genes for nucleotide excision repair.

19 ucleotide oligonucleotides by the process of nucleotide excision repair.

20 s lesion and its ability to be recognized by nucleotide excision repair.

21 rA2 dimer finds lesions in DNA and initiates nucleotide excision repair.

22 pair of the branched-chain lesions relied on nucleotide excision repair.

23 be mediated by a TTF-1-imposed alteration on nucleotide excision repair.

24 to essentially all DNA damages processed by nucleotide excision repair.

25 or required for transcription initiation and nucleotide excision repair.

26 bulky lesions more commonly associated with nucleotide excision repair.

27 f about 500 kDa, TFIIH is also essential for nucleotide excision repair.

28 DE-dG), which are removed from the genome by nucleotide excision repair.

29 st contractions, but through BER rather than nucleotide excision repair.

30 e (Pol) II and trigger transcription-coupled nucleotide excision repair.

31 hesis of up to 30 nucleotides during base or nucleotide excision repair.

32 air pathways of homologous recombination and nucleotide excision repair.

33 with the drug by removal of the damages with nucleotide excision repair.

34 ranscription-coupled repair, a subpathway of nucleotide excision repair.

35 compromised arises via transcription-coupled nucleotide excision repair, a previously identified cont

36 rs the DNA unwinding activity of XPD and the nucleotide excision repair activity of TFIIH.

37 UvrD helicase is required for nucleotide excision repair, although its role in this pr

38 ingly, we find that the loss of p21 restores nucleotide excision repair and apoptosis in Ddb2(-/-) mi

39 ated an antagonistic role of DDB2 and p21 in nucleotide excision repair and apoptosis.

40 TFIIH, and these mutations lead to impaired nucleotide excision repair and basal transcription.

41 of the CRL4-CSN complex, thereby regulating nucleotide excision repair and cell death.

42 duced a protein that had full capacities for nucleotide excision repair and cisplatin resistance.

43 Here, we aimed to better define the roles of nucleotide excision repair and DNA damage in platinum ch

44 oint, and Ercc1(-/Delta7) mice, defective in nucleotide excision repair and inter-strand cross-link r

45 B2), a nuclear protein, participates in both nucleotide excision repair and mRNA transcription.

46 -peptide conjugates, which can be subject to nucleotide excision repair and replication bypass.

47 ol kappa), which has been implicated in both nucleotide excision repair and trans-lesion synthesis, r

48 tains a [4Fe-4S] cluster and is critical for nucleotide excision repair and transcription.

49 mplex is a versatile factor involved in both nucleotide excision repair and transcriptional coactivat

50 Mfd couples transcription to nucleotide excision repair, and acts on RNA polymerases

51 ch a scenario reflects a natural step during nucleotide excision repair, and given that the germline

52 unctions in methyl-directed mismatch repair, nucleotide excision repair, and homologous recombination

53 structure-specific endonuclease required for nucleotide excision repair, and incision-defective XPG m

54 to global genome repair-specific elements of nucleotide excision repair, and suggests that TCR is a m

55 Mitochondria lack nucleotide excision repair, and therefore, it is importa

56 mologous recombination, DNA mismatch repair, nucleotide excision repair, and translesion DNA synthesi

57 recognition of such DNA lesions by the human nucleotide excision repair apparatus, are discussed.

58 scription-coupled DNA repair (TCR) branch of nucleotide excision repair, are hypersensitive to cispla

59 Consequently, nucleotide excision repair at an actively transcribed ge

60 roles in cells including an association with nucleotide excision repair, base excision repair, mismat

61 These lesions are removed through nucleotide excision repair because humans lack a DNA gly

62 nd recruits the enzymes involved in base and nucleotide excision repair (BER and NER).

63 In nucleotide excision repair, bulky DNA lesions such as UV

64 V600E) and ARF deletion synergize to inhibit nucleotide excision repair by epigenetically repressing

65 oderma pigmentosum C (XPC) complex initiates nucleotide excision repair by recognizing DNA lesions be

66 r essential for initiating the global genome nucleotide excision repair by recognizing the DNA lesion

67 ntrols general transcription and UVR-induced nucleotide excision repair by transactivation of GTF2H1

68 ty is modulated by the transcription-coupled nucleotide excision repair capacity.

69 e absence of DNA damage the yeast Rad4-Rad23 nucleotide excision repair complex binds to the promoter

70 n yeast as well as human cells, and that the nucleotide excision repair complex, Rad10-Rad1(ERCC1-XPF

71 ognized by the xeroderma pigmentosum C (XPC) nucleotide excision repair complex.

72 XPD, a 5'-3' helicase involved in nucleotide excision repair, contains a [4Fe-4S] cluster

73 portant for genomic stability including XPD (nucleotide excision repair), DDX11 (sister chromatid coh

74 XP patients have a nucleotide excision repair defect and a 10,000-fold incr

75 n on UV-damaged DNA, which is independent of nucleotide excision repair, demonstrating a clear requir

76 essive diseases that belong to the family of nucleotide excision repair disorders.

77 into DNA double-strand breaks (DSBs) by the nucleotide excision repair endonucleases XPF and XPG.

78 air by promoting backtracking and recruiting nucleotide excision repair enzymes to exposed lesions.

79 shielded by blocked RNA polymerase, allowing nucleotide excision repair enzymes to gain access to sit

80 a suggest that the key transcription-coupled nucleotide excision repair factor (TC-NER) Cockayne synd

81 se activity but independent of the essential nucleotide excision repair factor XPA.

82 Here we have used purified core nucleotide excision repair factors (RPA, XPA, XPC, TFIIH

83 Among these, nucleotide excision repair factors promote CDT1 destruct

84 corporation during replication, or incorrect nucleotide excision repair following oxidative damage.

85 a critical DNA damage recognition factor in nucleotide excision repair for which genetic deficiency

86 that MrfAB function independent of canonical nucleotide excision repair, forming a novel excision rep

87 In contrast, even though nucleotide excision repair gene homologs have been found

88 Human nucleotide excision repair generates two incisions surro

89 single-nucleotide polymorphisms of selected nucleotide excision repair genes and arterial stiffness

90 mic instability resulting from the defective nucleotide excision repair genes ERCC1 and XPD (Ercc1(d/

91 Mutations in nucleotide excision repair genes were associated with su

92 a mechanism for its anticancer activity, the nucleotide excision repair genes were studied in bone ma

93 n initiates the global genomic subpathway of nucleotide excision repair (GG-NER) for removal of UV-in

94 We recently demonstrated that global genome-nucleotide excision repair (GG-NER) in chromatin is orga

95 modeled at lesion sites in the global genome nucleotide excision repair (GG-NER) pathway.

96 for by selective resistance to global-genome nucleotide excision repair (GG-NER).

97 sruption of Xpc, essential for global-genome nucleotide excision repair (ggNER) of helix-distorting n

98 have been found in plants, the mechanism of nucleotide excision repair has not been investigated.

99 4 (D4) revealed no particular sensitivity to nucleotide excision repair, homologous recombination rep

100 how the protein functions within and beyond nucleotide excision repair in cells.

101 Nucleotide excision repair in Escherichia coli is stimul

102 at the G*[C8-N3]T* lesions are substrates of nucleotide excision repair in human cell extracts.

103 ficient substrates for transcription-coupled nucleotide excision repair in human cells.

104 leotide excision repair system in E. coli by nucleotide excision repair in humans.

105 e congruence of in vivo and in vitro data on nucleotide excision repair in humans.

106 at the 8-MOP photoadducts are substrates for nucleotide excision repair in mammalian cells.

107 nd (6-4)PP photolyases, as well as genes for nucleotide excision repair in plants, such as Arabidopsi

108 , we examined a potential role for canonical nucleotide excision repair in the removal of ribonucleot

109 method have enabled genome-wide analysis of nucleotide excision repair in various organisms at singl

110 approach for studying the mechanism of human nucleotide excision repair in vivo.

111 Nucleotide excision repair is a major DNA repair mechani

112 Nucleotide excision repair is a versatile mechanism to r

113 Nucleotide excision repair is an important and highly co

114 or that mediates both ATR-CHK1 signaling and nucleotide excision repair is replication protein A, and

115 leotide single-stranded DNA gap generated by nucleotide excision repair is the signal that activates

116 Nucleotide excision repair is the sole mechanism for rem

117 These results suggest that nucleotide excision repair is unlikely to play a major r

118 If the nucleotide excision repair machinery does not promptly r

119 zyme from the DNA, and recruits the Uvr(A)BC nucleotide excision repair machinery via UvrA binding.

120 ts normally recognized by Fanconi anemia and nucleotide excision repair machinery, although the mecha

121 teness of the DNA damage to be mended by the nucleotide excision repair machinery.

122 lly mutagenic if not properly removed by the nucleotide excision repair machinery.

123 tandem duplications suggests that errors in nucleotide excision repair may be resolved via a similar

124 Mitochondria lack a functional nucleotide excision repair mechanism to repair DNA adduc

125 acity in any four of the following pathways: nucleotide excision repair, mismatch repair, base excisi

126 d cisplatin-induced gap-filling synthesis in nucleotide excision repair (NER) and a reduced dATP leve

127 ve demonstrated that certain proteins of the nucleotide excision repair (NER) and base excision repai

128 ependent role in stabilizing DDB2 to promote nucleotide excision repair (NER) and govern cisplatin re

129 ultiple DNA damage repair pathways including nucleotide excision repair (NER) and inter-strand crossl

130 oup A (XPA) is a crucial factor in mammalian nucleotide excision repair (NER) and nuclear import of X

131 Global nucleotide excision repair (NER) and transcription-coupl

132 sions, cdG and cdA are repaired by the human nucleotide excision repair (NER) apparatus.

133 Given the use of nucleotide excision repair (NER) as a backup pathway for

134 35 (ATR-pS435), a modification that enhances nucleotide excision repair (NER) by facilitating recruit

135 Mutations in nucleotide excision repair (NER) components (e.g. XPA-1

136 Nucleotide excision repair (NER) consists of global geno

137 -coupled DNA repair (TCR) is a subpathway of nucleotide excision repair (NER) dedicated to rapid remo

138 s affecting TFIIH has been attributed to the nucleotide excision repair (NER) defect as well as to im

139 Nucleotide excision repair (NER) defects are associated

140 N(2)-dG (G*), manifests large differences in nucleotide excision repair (NER) efficiencies in DNA dup

141 formation and resulted in 2- to 3-fold lower nucleotide excision repair (NER) efficiencies in Escheri

142 Nucleotide excision repair (NER) efficiencies of DNA les

143 Chl are efficiently repaired by a dedicated Nucleotide Excision Repair (NER) enzyme.

144 Nucleotide excision repair (NER) excises bulky DNA lesio

145 We have performed nucleotide excision repair (NER) experiments in human He

146 , a central DNA damage recognition factor in nucleotide excision repair (NER) extensively regulated b

147 n NSs is similar to OmegaXaV motifs found in nucleotide excision repair (NER) factors and transcripti

148 The transcription of ERCC1 and other nucleotide excision repair (NER) genes is strongly influ

149 Nucleotide excision repair (NER) has long been known to

150 acologically-induced cAMP signaling promotes nucleotide excision repair (NER) in a cAMP-dependent pro

151 A prominent role for nucleotide excision repair (NER) in disease caused by My

152 Nucleotide excision repair (NER) in eukaryotes is orches

153 an tissues and whether it is a substrate for nucleotide excision repair (NER) in vivo.

154 Nucleotide excision repair (NER) is a conserved and vers

155 Nucleotide excision repair (NER) is a highly conserved p

156 Nucleotide excision repair (NER) is a major DNA repair p

157 Nucleotide excision repair (NER) is a major repair pathw

158 Nucleotide excision repair (NER) is a very important def

159 Nucleotide excision repair (NER) is an evolutionarily co

160 Nucleotide excision repair (NER) is critical for maintai

161 Nucleotide excision repair (NER) is critical for the rep

162 Nucleotide excision repair (NER) is responsible for prot

163 Nucleotide excision repair (NER) is responsible for the

164 Nucleotide excision repair (NER) is shown to not play a

165 Nucleotide excision repair (NER) is the key DNA repair s

166 Nucleotide excision repair (NER) is the principal pathwa

167 Nucleotide excision repair (NER) is the sole mechanism i

168 How the nucleotide excision repair (NER) machinery gains access

169 sitioning of repair factors in multi-protein nucleotide excision repair (NER) machinery.

170 tial scaffolding protein in the multiprotein nucleotide excision repair (NER) machinery.

171 The molecular basis of resistance to nucleotide excision repair (NER) of certain bulky DNA le

172 In yeast, nucleosomes inhibit nucleotide excision repair (NER) of the nontranscribed s

173 Strains with mutations in the nucleotide excision repair (NER) pathway genes uvrC or u

174 G adducts can be efficiently repaired by the nucleotide excision repair (NER) pathway in normal human

175 Effective repair of such lesions by the nucleotide excision repair (NER) pathway is required to

176 XPA is an essential protein in the nucleotide excision repair (NER) pathway, in charge of r

177 terations in another DNA repair pathway, the nucleotide excision repair (NER) pathway, which may exhi

178 hotosensitive diseases with mutations in the nucleotide excision repair (NER) pathway, which repairs

179 dual-incision endonuclease in the bacterial nucleotide excision repair (NER) pathway.

180 lease, is best known for its function in the nucleotide excision repair (NER) pathway.

181 cal role in the repair of DNA damage via the nucleotide excision repair (NER) pathway.

182 fic DNA lesions, which are the substrates of nucleotide excision repair (NER) pathway.

183 sed skin cancer, is caused by defects in the nucleotide excision repair (NER) pathway.

184 uplex DNA, these lesions are repaired in the nucleotide excision repair (NER) pathway.

185 ases and can potentially be repaired via the nucleotide excision repair (NER) pathway.

186 4)-POBdT could be subjected to repair by the nucleotide excision repair (NER) pathway.

187 DNA-binding protein that participates in the nucleotide excision repair (NER) pathway.

188 response to UV light-induced DNA damage, the nucleotide excision repair (NER) pathways are activated

189 Nucleotide excision repair (NER) plays a vital role in p

190 Nucleotide excision repair (NER) protects against sunlig

191 Nucleotide excision repair (NER) protects cells against

192 Nucleotide excision repair (NER) proteins have been foun

193 We find that the nucleotide excision repair (NER) proteins UvrA, UvrB, an

194 eIF3a negatively regulates the synthesis of nucleotide excision repair (NER) proteins, and, in turn,

195 study this, we measured the distribution of nucleotide excision repair (NER) rates for UV-induced le

196 However, whether SIRT6 regulates nucleotide excision repair (NER) remains unknown.

197 Nucleotide excision repair (NER) removes a wide range of

198 Nucleotide excision repair (NER) removes chemically dive

199 Nucleotide excision repair (NER) removes these photoprod

200 Nucleotide excision repair (NER) removes various DNA les

201 that can yield mechanistic information about nucleotide excision repair (NER) stimulated by cAMP-depe

202 red the stability of 26 proteins involved in nucleotide excision repair (NER) under normal growth con

203 Here we report that USP7 regulates nucleotide excision repair (NER) via deubiquitinating xe

204 ity, small changes in mismatch repair (MMR), nucleotide excision repair (NER), and homologous recombi

205 UV-DDB, a key protein in human global nucleotide excision repair (NER), binds avidly to abasic

206 ch two-strand mutations depend on functional nucleotide excision repair (NER), but the molecular mech

207 NA double-strand break (DSB) repair, but not nucleotide excision repair (NER), coevolves with longevi

208 In nucleotide excision repair (NER), damage recognition by

209 Nucleotide excision repair (NER), interstrand cross-link

210 uble-stranded DNA junctions and has roles in nucleotide excision repair (NER), interstrand crosslink

211 to DNA repair by base excision repair (BER), nucleotide excision repair (NER), mismatch repair (MMR),

212 ajor endpoints for assessing the activity of nucleotide excision repair (NER), the most versatile DNA

213 re hypersensitive to KP1019, suggesting that nucleotide excision repair (NER), translesion synthesis

214 Using repair-defective nucleotide excision repair (NER)-, mismatch repair-, and

215 We report here that a nucleotide excision repair (NER)-associated-factor is re

216 ged sites in a DNA replication-dependent but nucleotide excision repair (NER)-independent manner.

217 human cell extracts yields a characteristic nucleotide excision repair (NER)-induced ladder of short

218 IIH) is essential for both transcription and nucleotide excision repair (NER).

219 cisplatin-modified DNA in the nucleus by the nucleotide excision repair (NER).

220 ct of the initial damage recognition step in nucleotide excision repair (NER).

221 tial for RNA polymerase II transcription and nucleotide excision repair (NER).

222 d be expected to be more readily repaired by nucleotide excision repair (NER).

223 ge by flagging O(6)-alkylguanine lesions for nucleotide excision repair (NER).

224 l of ultraviolet (UV)-induced DNA lesions by nucleotide excision repair (NER).

225 XPC-RAD23B, a key initiator of global-genome nucleotide excision repair (NER).

226 ly mutagenic UVB-induced DNA photolesions by nucleotide excision repair (NER).

227 NA lesions caused by exposure to UV light is nucleotide excision repair (NER).

228 nator and structure-specific endonuclease in nucleotide excision repair (NER).

229 ion group A (XPA) mice that are deficient in nucleotide excision repair (NER).

230 anslational event required for cAMP-enhanced nucleotide excision repair (NER).

231 r for skin cancers, is primarily repaired by nucleotide excision repair (NER).

232 e associated with somatic alterations in the nucleotide- excision repair (NER) pathway has not yet be

233 toproducts are recognized and removed by the nucleotide-excision repair (NER) pathway.

234 or total DNA polymerase-blocking lesions and nucleotide excision repair of (6-4) photoproducts in vit

235 excision repair sequencing (XR-seq) to study nucleotide excision repair of DNA adducts in humans, mic

236 Hrq1 supports the nucleotide excision repair of DNA damage caused by the c

237 ys essential roles in both transcription and nucleotide excision repair of nuclear DNA, however, whet

238 XPC/Rad4 initiates eukaryotic nucleotide excision repair on structurally diverse helix

239 licative DNA polymerases and are repaired by nucleotide excision repair or bypassed by translesion po

240 DNA damage requires upstream involvement of nucleotide excision repair or UVDE repair enzymes.

241 AG repeats does not involve mismatch repair, nucleotide excision repair, or transcription, processes

242 -RAD23B complex is one of the key factors of nucleotide excision repair participating in the primary

243 ways, here we show its role in the versatile nucleotide excision repair pathway (NER) that removes a

244 have defects in seven of the proteins of the nucleotide excision repair pathway and in DNA polymerase

245 t 89% of tumors had at least one mutation in nucleotide excision repair pathway genes in African Amer

246 f UvrA and UvrD1, thought to be parts of the nucleotide excision repair pathway of M. tuberculosis.

247 The nucleotide excision repair pathway removes ultraviolet (

248 epaired damaged DNA utilizing genes from the nucleotide excision repair pathway without provoking PAE

249 ERCC2 is indispensable for nucleotide excision repair pathway, and its functional p

250 onent of the protein homeostasis network and nucleotide excision repair pathway, as a modifier of the

251 ires a specific sub-branch of the DNA damage nucleotide excision repair pathway, termed transcription

252 DNA after the lesion has been excised by the nucleotide excision repair pathway, while others partici

253 plays an essential role in DNA repair in the nucleotide excision repair pathway.

254 and XPF involves two major components of the nucleotide excision repair pathway.

255 ssential for the repair of DNA damage by the nucleotide excision repair pathway.

256 known to function in the mismatch repair and nucleotide excision repair pathways and has also been su

257 aryotes, DNA double-strand break repair, and nucleotide excision repair pathways.

258 into global genome or transcription-coupled nucleotide excision repair pathways.

259 We determined that nucleotide excision repair plays a key role in the remov

260 repair, the process of transcription-coupled nucleotide excision repair plays a role in the removal o

261 Nucleotide excision repair prevents up to 99% of point m

262 The nucleotide excision repair protein complex ERCC1-XPF is

263 uctural features and interactions with other nucleotide excision repair protein factors of the two en

264 Here, we show that the mammalian nucleotide excision repair protein homolog MMS19 can sim

265 with the RNA polymerase subunit RpoB and the nucleotide excision repair protein UvrA.

266 duct DDB2 (damaged DNA binding protein 2), a nucleotide excision repair protein, is upregulated by hy

267 USP22-sensitive ubiquitylome identified the nucleotide excision repair protein, XPC, as a critical m

268 col, the excised oligomers, generated in the nucleotide excision repair reaction, are isolated by cel

269 o psoralen crosslinks was independent of the nucleotide excision repair recognition factor, XPC.

270 ction exhibit essentially normal activity in nucleotide excision repair, revealing RPA separation of

271 ovided a 60 bp duplex, which is suitable for nucleotide excision repair studies.

272 leic acid (DNA) lesions by the global genome nucleotide excision repair subpathway is performed by th

273 factor II H (TFIIH) is a major actor of both nucleotide excision repair subpathways of which transcri

274 and results obtained in cells defective for nucleotide excision repair suggest that breakage of DNA

275 gested that ATLs target alkyl lesions to the nucleotide excision repair system (NER).

276 his damage is repaired by photolyase and the nucleotide excision repair system in E. coli by nucleoti

277 es are not efficiently targeted by the human nucleotide excision repair system in vitro or in culture

278 ggest that M. genitalium possesses an active nucleotide excision repair system, possibly representing

279 that possess mutations in components of the nucleotide excision repair system.

280 ubgroups with impaired transcription coupled nucleotide excision repair (TC-NER) (category 1: XP-A, B

281 formation requires the transcription-coupled nucleotide excision repair (TC-NER) factor Cockayne synd

282 Transcription-coupled nucleotide excision repair (TC-NER) is an important DNA

283 otoxicity by promoting transcription-coupled nucleotide excision repair (TC-NER) of cisplatin-induced

284 in cells deficient in transcription-coupled nucleotide excision repair (TC-NER) or global genomic NE

285 known for its role in transcription-coupled nucleotide excision repair (TC-NER), contains a ubiquiti

286 due to the activity of transcription-coupled nucleotide excision repair (TC-NER).

287 Transcription-coupled nucleotide excision repair (TCR) accelerates the removal

288 important and well-conserved sub-pathway of nucleotide excision repair that preferentially removes D

289 ual incisions, and repair resynthesis during nucleotide excision repair, the fate of the dual incisio

290 Here we show that E-cadherin promotes nucleotide excision repair through positively regulating

291 cells, however, disruption of Nrf1 impaired nucleotide excision repair through suppressing the trans

292 tes activate a specific repair pathway, i.e. nucleotide excision repair, to remove UVB-induced DNA le

293 en involves multiple repair pathways such as nucleotide-excision repair, translesion DNA synthesis (T

294 n coupled repair (TC-NER) is a subpathway of nucleotide excision repair triggered by stalling of RNA

295 es involved in removal of photo-damage (e.g. nucleotide excision repair uvrABC, recombinases recBCD a

296 ontrast, a deletion mutant for the predicted nucleotide excision repair uvrC gene showed growth defec

297 Previous reports have shown that both nucleotide excision repair, which is the sole pathway in

298 single strand breaks that are formed during nucleotide excision repair, which primarily removes bulk

299 The lesions can only be repaired by nucleotide excision repair with a low efficiency.

300 N1 5' nuclease superfamily members acting in nucleotide excision repair (XPG), mismatch repair (EXO1)