ライフサイエンスコーパス: null allele

1 null alleles) and LCA (four missense and one null allele).

2 1g(js) or Pcdh15(av-3J) alleles, or an Ush1c null allele.

3 y to self-associate cannot complement an lfy null allele.

4 retention of beta1B, generating a functional null allele.

5 not be forced to segregate to a homokaryotic null allele.

6 cts indistinguishable from those caused by a null allele.

7 as well as the partial lethality of the p38b null allele.

8 nd rescued the male lethality of the Bpa(1H) null allele.

9 lethality in female embryos homozygous for a null allele.

10 trap represents a hypomorphic rather than a null allele.

11 nthesis in sorghum, and the bmr6 mutant is a null allele.

12 , we generated mice with a conditional Hdac3 null allele.

13 o, we generated mice with a conditional PKD1-null allele.

14 ous deletion in Ddr2 to produce an effective null allele.

15 cognition target (FRT)-dependent conditional null allele.

16 ail to rescue the loss of Cdk8 and behave as null alleles.

17 erosis, nor do his relatives who carry APOL1 null alleles.

18 ease observed for each of two distinct fog-3 null alleles.

19 nse mutations than in those heterozygous for null alleles.

20 LacZ reporter allele, resulted in functional null alleles.

21 atio was highest among heterozygotes for VWF null alleles.

22 cngc16-1 and 16-2 were both loss-of-function null alleles.

23 causality is commonly tested with homozygous null alleles.

24 ltures harboring either two wild-type or two null alleles.

25 ess demyelination/dysmyelination than in the null alleles.

26 he function of yar was defined by generating null alleles.

27 mited by genetic redundancy and/or a lack of null alleles.

28 velopment [7, 11]; and tissue-specific hlh-2 null alleles.

29 among loci, a pattern usually suggestive of null alleles.

30 ockout mice, suggesting that these represent null alleles.

31 TPA suppression, indicating they function as null alleles.

32 llagen V, and is most often caused by COL5A1 null alleles.

33 iate between MYMK wild type, hypomorphic and null alleles.

34 n tumors and are thought to give rise to p53-null alleles.

35 3 patients with no VWFpp were homozygous for null alleles.

36 s often results in the generation of mutant (null) alleles.

37 Neither the missense nor the null allele affected TLR-induced secretion of IL-6.

38 premature termination mutations resulting in null alleles among ELN point mutations.

39 trast to our previous studies using the Hip1 null allele, an inhibition of tumorigenesis was not obse

40 X6 compound inheritance that combines a rare null allele and a common hypomorphic allele at the TBX6

41 In addition, using the Gli1 null allele and a Gli3 repressor allele, we reveal a spe

42 le CRE recombinase strain, a conditional p53-null allele and a loxP-stop-loxP activatable oncogenic K

43 we engineered a novel conditional p16(INK4a)-null allele and combined this allele with a melanocyte-s

44 We utilized mice heterozygous for a Snap25 null allele and deficient in SNAP-25 expression to model

45 containing the EDA isoform or contain an EDA-null allele and express only FN lacking EDA, with or wit

46 variant (T596A) of Sting that functions as a null allele and fails to produce detectable protein.

47 Here, we generated a Nek8-null allele and found that homozygous mutant mice die at

48 activity phenocopied the effects of an E2f8 null allele and led to HCC.

49 ecapitulated in knock-in mice that carry one null allele and one mutant allele of the p53 gene.

50 Compound inheritance of a rare null allele and one of two low-frequency SNPs in the reg

51 Transgenic mice heterozygous for a Trp53-null allele and overexpressing EGFR in Schwann cells had

52 We generated a nos-2 null allele and show that nos-2; xnd-1 double mutants di

53 nd cancer cell-enriched protein) conditional-null allele and showed that neural-specific knockout of

54 Mature plants of the regenerated null allele and the weak allele display remarkable flora

55 on, we tested specific Trbl antisera, a trbl null allele and Trbl transgenes bearing site-directed mu

56 Using unmarked Brn3-null alleles and Brn3 conditional alleles in which gene

57 opods (e.g., [5, 6]) and often segregate for null alleles and gene deletions [3, 4, 7, 8].

58 opportunity to test causality between APOL1 null alleles and glomerulosclerosis.

59 Null alleles and knockdowns of pumpkin were viable but c

60 Overall, given the null alleles and phenotypic assays used, we did not find

61 and takes into account of allelic dropouts, null alleles and prior knowledge of inbreeding.

62 nsistent with synergism between recG and ruv null alleles and reinforced when the protein was shown t

63 in patients with RP (three missense and two null alleles) and LCA (four missense and one null allele

64 nterpreted as technical issues (for example, null alleles), and that it is important to take such fac

65 isely delete foraging, generating the for(0) null allele, and used recombineering to reintegrate a fu

66 ed these results using genetic deficiencies, null alleles, and inducible RNAi transgenes.

67 ome case has yet been associated with COL5A2 null alleles, and phenotypes that might result from such

68 ly polymorphic, exhibited low frequencies of null alleles, and were easy to interpret with the aid of

69 ce we previously showed that CLPR2 and CLPR4 null alleles are always sterile and die on soil.

70 allele of the autonomous pathway gene fy (fy null alleles are embryo lethal) displayed background-spe

71 clv1 alleles are dominant negative, and clv1 null alleles are weak in phenotype, suggesting additiona

72 ngly, the hypersensitivity phenotype of ARP5 null allele arp5-1 is stronger than the severe knockdown

73 the common R555W mis-sense allele and a DYSF-null allele, as well as control human myoblast cultures

74 1g/L, respectively, whereas N variant was a 'null' allele associated with the absence of alphas1-case

75 ted mice that have one mutant allele and one null allele at the Tgfb1 locus, reasoning that these mic

76 4.2-fold increased risk for MI; carriers of null alleles at LDLR were at even higher risk (13-fold d

77 Drosophila apoptosis, we produced authentic null alleles at this locus.

78 we demonstrate that introduction of a Trp53-null allele attenuates the vertebral defects found in Pd

79 mutations, which act as the equivalent of a null allele because they result in the generation of sma

80 mline heterozygosity of mouse Sdhb/Sdhc/Sdhd null alleles blunts chronic hypoxia-induced increases in

81 on the I1 inner arm dynein (dynein f) and a null allele, bop5-2, defective in the gene encoding the

82 gon-2 loss-of-function mutants (including a null allele) can be suppressed by gain-of-function mutat

83 The null alleles cannot heat-acclimate as light-grown plants

84 CDH23 null alleles cause deaf-blindness (Usher syndrome type 1

85 Homozygosity for a null allele caused embryonic death, but hypomorphic alle

86 nse mutation FIG4(I41T) combined with a FIG4 null allele causes Charcot-Marie-Tooth 4J disease, a sev

87 The mouse Hinfp(LacZ) null allele causes early embryonic lethality due to a bl

88 mosaic eye imaginal discs, while ph(del), a null allele, causes only non-autonomous overgrowth, ph(5

89 with Ift172(avc1) and Ift172(wim), an Ift172 null allele: cilia were present on 42% of avc1 mouse emb

90 o-severe AD in European populations have FLG-null alleles compared with a general population frequenc

91 heterozygous for the patient mutation and a null allele (Copb2R254C/Zfn) show a severe perinatal phe

92 omparative leaf proteome analyses of a CLPR4 null allele demonstrate a central role of Clp protease i

93 ecp2 heterozygotes, which are mosaic for the null allele, demonstrated that electrical hyperexcitabil

94 These null alleles, designated as y1-ww1 and y1-ww4, do not ac

95 vo setting, mice heterozygous for an MT1-MMP-null allele display a distinct survival advantage and re

96 Mice heterozygous for either Pcbp1 or Pcbp2 null alleles display a mild and nondisruptive defect in

97 otype, mice heterozygous for a Ccm1- or Ccm2-null allele do not develop CCM lesions.

98 protein lacking the catalytic domain, or the null allele du1-R4059.

99 The null allele e resulted from an insertional disruption in

100 Embryos bearing null alleles exhibited laminin deficiency prior to mesen

101 stases were primarily negative for the fgfr1 null allele, exhibited high FGFR1 expression, and a neur

102 Although statistical support for null alleles existed, their presence would also be expec

103 Plants with NRB4 null alleles express profound insensitivity to SA, even

104 A targeted Zfp318 null allele extinguished IgD expression on mature B cell

105 ing seed development the effect of the cac1a null allele first becomes apparent at 3-d after flowerin

106 mained untested in the mouse, we generated a null allele for Cv2 which was crossed to Tsg and Chd mut

107 A mouse line with a null allele for Glut3 has been developed.

108 We isolated a zebrafish opa3 null allele for which homozygous mutants display increas

109 ccharomyces cerevisiae led us to reconstruct null alleles for both genes and prove that yrdC is essen

110 By contrast, null alleles for CLPP5 were embryo lethal.

111 Null alleles for CLPR2 and CLPR4 showed delayed embryoge

112 generated animals containing combinations of null alleles for each receptor, especially animals expre

113 unction during retinal development, multiple null alleles for optix have been generated.

114 elopment, we used mice harboring conditional null alleles for Sox4 and a Cre transgene.

115 Null alleles for the COL5A1 gene and missense mutations

116 We describe mice with null alleles for the Col5a2.

117 in double mutants combining bk4 with bk2 or null alleles for two CesA genes, confirmed interaction o

118 Twenty-eight mutations were novel, with null alleles frequently found in trans to missense mutat

119 Mice homozygous for the null allele had a defect in spermatogenesis that resulte

120 nd the glutathione-S-transferase-mu1 (GSTM1) null allele have been shown separately to associate with

121 to other tasiR-ARF biogenesis mutants, dcl4 null alleles have an uncharacteristically mild phenotype

122 However, COL5A2 null alleles have yet to be associated with cEDS or othe

123 lusive since Crb1 mouse mutants, including a null allele, have failed to mimic the early-onset of LCA

124 e presence of technical issues (for example, null alleles), hierarchical structure (for example, host

125 Mdh1 null allele homozygotes show reductions in tolerance.

126 In ry506 (null allele) homozygotes or hemizygotes, JH III or pyrip

127 Screening of the ATM gene revealed a null allele in 2 of 23 (8.7%) patients of European ances

128 Plants homozygous for a null allele in AAO4 showed a reduction of 30% to 45% in

129 vivo model, we used mice heterozygous for a null allele in Bmpr2 (Bmpr2(+/-)) and wild-type litterma

130 to the y locus and showed the same recessive null allele in homozygosis: Deltay A set of molecular an

131 We generated a Wbp11 null allele in mouse using CRISPR-Cas9 targeting.

132 activity to levels comparable to the fad2-1 null allele in nearly all transgenic events.

133 Furthermore, a phyB null allele in the abp1-5 background is likely causative

134 ion J (orJ) mouse, which harbors a recessive null allele in the Vsx2 gene.

135 amed Aoba, represents the first functionally null allele in this species.

136 is to develop a screening method to generate null alleles in a human cell line haploid for all chromo

137 but the early embryonic lethality of Dicer1 null alleles in mice has limited our ability to address

138 (dysb), in isolation or in combination with null alleles in the dysb network component Blos1.

139 Null alleles in the genes encoding each enzyme were cons

140 Since null alleles in the heterozygous state lead to suppressi

141 inducible Cre transgene and Sox9 conditional null alleles in the mouse, we show that Sox9 is required

142 Null alleles in these genes result in an oogenesis block

143 c differences between drosha and pasha/dgcr8 null alleles in two postembryonic lineages in the Drosop

144 Here, we identify QIL1 null alleles in two siblings displaying multiple clinica

145 utant animals by simplifying the creation of null alleles in virtually any organism.

146 proaches for synthetic genetic analysis with null-alleles in metazoans have not been feasible.

147 s, while HA-1(R) has been suggested to be a "null allele" in terms of T cell reactivity.

148 such as false alleles and allelic dropouts (null alleles) in situations such as SNPs from low-covera

149 nscription factor Cdx2, alone or with a Cdx1 null allele, in the adult gastrointestinal tract.

150 oss-of-function alleles, including a natural null allele, in three other accessions, all of which had

151 These null alleles include copy-number variants (12 instances

152 Surprisingly, our characterization of a seh1 null allele indicates that, although required in the fem

153 GN results in the same phenotypes as the pgn null allele, indicating that a tight regulation of the P

154 rgeting this pathway, we introduced the Fn14 null allele into the MRL-lpr/lpr lupus mouse strain.

155 A mpk6, but not a mpk3, null allele is able to suppress the effects of this domi

156 ciliopathy Joubert syndrome, while the mouse null allele is embryonic lethal.

157 ss-of-function from enhanced inactivation or null alleles is rare and has been associated with myasth

158 The seed-specific phenotype of bcat2 null alleles, its strong transcription induction during

159 wnregulated in reproductive meristems of the null allele kn1-e1.

160 Importantly, mice heterozygous for the K9-null allele (Krt9(+/-)) show neither an overt nor histol

161 P2 knockout mice and human patients with RP2 null alleles leads to XLRP resembling recessive rod-cone

162 ventional gene targeting of Jak2, creating a null allele, leads to a block in definitive erythropoies

163 We isolated a null allele (lre-5) of LORELEI, which encodes a putative

164 Igf2r null-allele maternal transmission results in placenta an

165 ontrast to waltzer mice, which carry a CDH23 null allele mimicking USH1D, hair cell development is un

166 n this study, we generated an inducible Drd2 null-allele mouse strain that circumvented developmental

167 Mice homozygous for a MTAP null allele (Mtap(lacZ)) have an embryonic lethal phenot

168 hile, we regenerated a mature plant from the null allele mtnam-1.

169 r, differences between the phenotypes of the null allele mutants suggest that they play different rol

170 geneity and gene dosage effects in the mouse null alleles muted (Bloc1s5(mu/mu)) and dysbindin (Bloc1

171 ice homozygous for the Prkdc(scid) and Il2rg(null) alleles (NSG mice) permit engraftment of a wide-ra

172 the WAK2 dominant allele is suppressed by a null allele of a pectin methyl esterase (PME3) whose act

173 ermline phenotypes of flies homozygous for a null allele of asun (asun(d93)).

174 ith this prediction, mice heterozygous for a null allele of Bicc1 had low BMD.

175 arrying the Bmp7(R-G) allele together with a null allele of Bmp2 or Bmp4 die during embryogenesis wit

176 hronotoxicity of APAP, we used a conditional null allele of brain and muscle Arnt-like 1 (Bmal1, aka

177 We generated a null allele of car to test its requirement for trafficki

178 0 (Cep290(rd16/+)) but not of a heterozygous null allele of Cep290 (Cep290(null/+)) or of other cilio

179 Mice harboring a null allele of Csnk1e showed an increase in locomotor ac

180 Here we characterize a novel null allele of Dnaaf2 obtained from the International Mo

181 A transcriptional null allele of exo70a2 also suppressed the hpat1/3 ferti

182 To understand this further, we introduced a null allele of Fancc (Fancc-), encoding a member of the

183 The toku phenotype was attributed to a null allele of Gk5, encoding glycerol kinase 5 (GK5), a

184 a systematic reverse genetic screen using a null allele of HMT1 and the synthetic genetic array (SGA

185 We developed a conditional-null allele of Ifnar1 and used tissue-specific induction

186 Complementation testing with an engineered null allele of Il2ra, however, showed that jal is a muta

187 ve mouse mutants, we identified a functional null allele of inositol polyphosphate-5-phosphatase E (I

188 tic cell line that expresses a conditionally null allele of Ku86.

189 ic and respiratory phenotypes of mice with a null allele of Mecp2 to mice with Mecp2 removed from the

190 ve identified sister of open brain (sopb), a null allele of mouse Intraflagellar transport protein 12

191 Here we report that a null allele of mouse nucleoporin Nup133, a structural su

192 We identified a null allele of mouse Ttbk2 based on loss of Sonic hedgeh

193 ut class genes, small RNA populations from a null allele of mut-16 as well as a regulatory mut-16(mg4

194 Furthermore, mice heterozygous for a null allele of Nrip1 showed a CAKUT-spectrum phenotype.

195 ution of Ntn1 to development, we generated a null allele of Ntn1 and re-examined tissues exhibiting p

196 We then produced a viable null allele of oga (oga(del.1)) in Drosophila allowing v

197 n double heterozygous embryos also carried a null allele of p53.

198 Embryos that are homozygous for Splotch, a null allele of Pax3, have a severe neural crest cell (NC

199 Mice heterozygous for a null allele of prkar1a (Prkar1a(+/-)), the primary recep

200 present the identification of an unreported null allele of Pun1 from a non-pungent accession of Caps

201 ogical approaches indicate that tvrm148 is a null allele of Rpe65.

202 A genetic null allele of rpk confirms its critical role in touch r

203 To explore these issues, we created a null allele of Set7/9 in mice.

204 rthermore, germ-line clones homozygous for a null allele of shaggy (Drosophila GSK-3beta) both fail t

205 ALB/c background, or when heterozygous for a null allele of superoxide dismutase 2 (Sod2(+/-)).

206 V) collagen chains by generating mice with a null allele of the alpha3(V) gene Col5a3 (Col5a3-/- mice

207 In contrast, transfer DNA insertional null allele of the CAC1A gene is embryo lethal and delet

208 orn1)) mice are homozygous for a spontaneous null allele of the destrin (Dstn) gene, which is also kn

209 nur7/nur7) mice that were heterozygous for a null allele of the gene that encodes the enzyme UDP-gala

210 f type 2 diabetes in mice heterozygous for a null allele of the insulin receptor and an N-ethyl-N-nit

211 ease iRhom2, which was not complemented by a null allele of the same gene.

212 ) and was mimicked by a CRISPR/Cas9-targeted null allele of the same gene.

213 We generated a null allele of the single Drosophila ortholog to gain fu

214 Here, we have generated a definitive null allele of the Skt/Etl4 gene and analysed homozygous

215 ccurs in the context of heterozygosity for a null allele of the tumor suppressor gene Pten, there is

216 oelectrics of neonatal mice homozygous for a null allele of Tmem16a (Tmem16a(-/-)) to investigate the

217 to develop by birth in mice homozygous for a null allele of Tmem16a (Tmem16a(tm1Bdh)(/tm1Bdh)) and di

218 We report that all mice homozygous for a null allele of Tmem16a died within one month of birth an

219 ked Klein-Zschocher (KLZ) mutation created a null allele of Yipf6, a member of a gene family believed

220 We generated mice with a conditional null allele of Zfp148 (ZBP-89(FL/FL)) using homologous r

221 z1Delta is synthetic sick or lethal with the null alleles of about 200 nonessential genes.

222 We performed mutant analysis with the null alleles of ABP1, abp1-c1 and abp1-TD1, and the TILL

223 nic Kras allele (Kras(mut) ) and conditional null alleles of Apc and Trp53 (iKAP).

224 We utilized point mutations and null alleles of BBS proteins to disrupt assembly of the

225 of emerin and LEM2 in somatic cells, we used null alleles of both genes to generate C. elegans animal

226 s severely affected in male embryos carrying null alleles of both Spry1 and Spry2.

227 between male C57BL/6J mice heterozygous for null alleles of Cacna1c and Tcf7l2 and wild-type females

228 itional mutant crd1Deltapsd1Delta containing null alleles of CRD1 (CL synthase) and PSD1 (mitochondri

229 We use hypomorphic and null alleles of Foxc1 to study the effect of meningeal d

230 Next, we produced conditional null alleles of Glutamic acid decarboxylase 1 (Gad1) and

231 d between mice and humans carrying biallelic null alleles of JAK3, TYK2, STAT1, or STAT5B.

232 animals were crossed to mice homozygous for null alleles of MMP-2, MMP-7, or MMP-9 genes.

233 Two null alleles of ns3, and RNAi, demonstrate the necessity

234 eye and ear is similar to that reported for null alleles of Pax2.

235 unctional interaction between RIP1 and FADD, null alleles of RIP1 were crossed into Fadd(-/-) mice.

236 Null alleles of SIEL are embryonic lethal.

237 rity between hypomorphic alleles of AGO1 and null alleles of SQN and by the genetic interaction betwe

238 We have exploited viable null alleles of the enzymes of O-GlcNAc cycling to exami

239 Null alleles of the gene encoding NEMO (NF-kappaB essent

240 The mutations generated null alleles of the saiR gene and resulted in elevated s

241 It was unclear why two null alleles of the same gene would give different pheno

242 We generated null alleles of the single Drosophila ZO protein Polycha

243 titatively assessed their ability to produce null alleles of their target gene by antibody staining a

244 nses to dilute octanol in animals containing null alleles of these 5-HT receptors.

245 generated using conditional hypomorphic and null alleles of Tsc2 combined with the neuron-specific s

246 Two null alleles of TUP5 caused a reduced viability of gamet

247 By generating a conditional null allele, one study proposed that the dpp stripe is c

248 e in JAZ1, JAZ3, JAZ4, JAZ9, and JAZ10, phyB null alleles only weakly alleviated the growth and repro

249 d that introduction of the gamma-sarcoglycan-null allele onto the DBA/2J background confers a more se

250 sion is eliminated or diminished in an hlh-8 null allele or in hlh-2 (CeE/DA) RNAi, respectively.

251 is in mice homozygous for either the Tyrc-2J null allele or the Tyrc-h allele, which model OCA-1A and

252 Previous animal models carrying either a null allele or transgenic manipulation of Ngf or Trka ha

253 al explants from embryos with different Sfrp-null alleles or explants overexpressing ADAM10 extend ax

254 in cells with missense alleles, but not with null alleles, or by over-expressing calnexin, a calcium-

255 and ethylene, resembling the sunn-4 presumed null allele phenotype.

256 plementation testing between jal and a Gata3 null allele produced doubly heterozygous, phenotypically

257 A null allele recq4(19) causes a failure in cell prolifera

258 related to amplification anomalies, such as null alleles, relative to loci with more limited use.

259 cells, and cells expressing a Foxp3 reporter null allele revealed that the majority of Foxp3-dependen

260 Two independent null alleles revealed that Copb2 is essential for early

261 n addition, phenotypic analysis of a mett-10 null allele reveals that METT-10 enables mitotic cell cy

262 Frequency of the Duffy-null allele (rs2814778; an African ancestral variant ado

263 b(+/W)) with mice heterozygous for the Scn1b-null allele (Scn1b(+/-)) to determine whether the C121W

264 Null alleles (sgb11/esk1-7) of ESK1 restore to wild-type

265 le heterozygotes carrying both Pten and Tsc2-null alleles showed no increase relative to Pten(+/-) he

266 mutations, but 12Gso is clearly not a global null allele since homozygotes survive into adulthood.

267 bstitution and the presence of low-frequency null alleles suggest a postduplication relaxation of pur

268 th these phenotypes, mice carrying the fgfr1 null allele survived significantly longer than those wit

269 plementation of the phenotype of the diploid null allele, tam-2 2C by a genomic fragment containing t

270 Null-allele test on cDNA from patients' fibroblasts of b

271 We generated a genetic null allele that reveals Socs36E is required in the ante

272 The Prpf31-knockout mice mimic the null alleles that result from the majority of mutations

273 In addition, we find several "null" alleles that have mutations on the derived Dox bac

274 Unlike a perR null allele, the perR991 allele (F51S) derepresses KatA,

275 p.W253X) in the first exon is likely to be a null allele; the second, a missense mutation (p.I201F) w

276 Here we used mice with a conditional null allele to establish the timing and cell type that u

277 nd cooperates with heterozygosity for a Pten null allele to promote hyperactive PI3K/AKT signaling.

278 We then produced Rp2-null allele using transgenic mice that expressed Cre-rec

279 The Duffy-null allele was associated with TNBC risk in our cohort.

280 A Dmap1-null allele was generated to study the role of DMAP1 in

281 f the protein fragment produced by the MARF1 null allele was incorrectly labelled as '34aa' rather th

282 In contrast, we found that the DOalpha F114L null allele was linked with viral clearance.

283 Similar circumstances existed when the CMAH null allele was polymorphic in ancestral hominins, just

284 tase-dead PTEN mutant (C124S) and maintain 1 null allele, we show that PTEN phosphatase activity is r

285 Using newly generated null alleles, we demonstrate that polychaetoid (pyd), th

286 Here, using null alleles, we demonstrate that the regulation of Axin

287 the cholesterol-binding domain of APP or APP null alleles, we found that while CE also regulate Abeta

288 omozygous or heterozygous for the Tau (Mapt) null allele were found to exhibit increasing levels of a

289 animals heterozygous for the germline Stat5 null allele were subjected to CHS.

290 nse alleles and two T-DNA insertion, protein null alleles were characterized.

291 Sprn null alleles were produced that delete all protein codin

292 bop5-3, bop5-4, and bop5-5 are null alleles, whereas bop5-6 is an intron mutation that

293 Some AEBP1 mutations were null alleles, whereas others resulted in expressed prote

294 To test this hypothesis, we bred an Xpa null allele, which eliminates NER, into the TNR mouse mo

295 ions in RanGAP levels by combining a RanGAP1 null allele with different RanGAP2 alleles.

296 se mouse is required for the generation of a null allele with the IKMC cassette.

297 ve adhesion phenotype in embryos bearing the null allele with those carrying the 'traditional' knocko

298 Null alleles with ACC2 nonsense mutations, frameshift mu

299 We compare the phenotypes of Mmp1 null alleles with alleles that have specific hemopexin d

300 The correlation of null alleles with human phenotypes can provide insight i