ライフサイエンスコーパス: null mice

1 activity (determined using A(1)AR or A(3)AR null mice).

2 -wounding but are completely absent in TSG-6-null mice.

3 also observed in nonobese wild-type and LepR-null mice.

4 Syn1 and Bdnf in the embryonic brain of Arx-null mice.

5 emperature in wild-type mice but not in Opn5-null mice.

6 ynia in female WT mice, but not in the HCAR2-null mice.

7 h human and mouse platelets but not in PTPN7-null mice.

8 he dystrophic phenotype in alpha-sarcoglycan-null mice.

9 However, some loci are unaffected in Zfp57-null mice.

10 gene expression in PPK-like lesions of Krt16-null mice.

11 itive neutrophils was transferrable to OLFM4 null mice.

12 xybutyrate (BHB) in wild-type (WT) and HCAR2-null mice.

13 d on OL progenitor cells purified from Thap1 null mice.

14 eased rate of arrhythmia in heterozygous and null mice.

15 -type C57BL/6 mice, cIAP2-null mice, or XIAP-null mice.

16 econstitute the vascular dysfunction in CD36-null mice.

17 ce but are profoundly impaired in BK channel-null mice.

18 of Whsc1 prevented tumor progression in PTEN-null mice.

19 PPARgamma suppression causes alopecia in VDR-null mice.

20 icantly increased in Mybphl heterozygous and null mice.

21 autophagy inhibition is attenuated in FGF15-null mice.

22 del of CKD-mineral bone disorder and alphaKL-null mice.

23 gets and in genes upregulated in miR-132/212 null mice.

24 e in the lung of wildtype but not caveolin-1-null mice.

25 th increased metastasis as compared with p53-null mice.

26 in (AG) and UAG were abolished in male GHS-R-null mice.

27 CYP2A13/2F1-humanized mice than in Cyp2abfgs-null mice.

28 the exaggerated fibrosis observed in Twist1-null mice.

29 lial-to-mesenchymal transition (EMT) in Pten-null mice.

30 ng persistent DNA damage in p53R172H and p53-null mice.

31 were measured in 16HBE cells and claudin-18 null mice.

32 ked the defective hypoxic responses of Epas1-null mice.

33 tagonist or is completely abolished in Trpv1 null mice.

34 reviously reported for Rnaseh2b- or Rnaseh2c-null mice.

35 le acid metabolism was also evident in Gpat3-null mice.

36 tion compensates for PKMzeta loss in PKMzeta-null mice.

37 ol6a2Deltaex5 mice than in gamma-sarcoglycan-null mice.

38 nt or at the onset of RTT phenotype in Mecp2-null mice.

39 eletal muscle pathology in gamma-sarcoglycan-null mice.

40 btained from the developing calvaria of DSPP-null mice.

41 ge was seen among matrix metalloproteinase-8 null mice.

42 rginally higher compared with Akita and Ncf1 null mice.

43 ntagonist reduced ileal inflammation in SHIP-null mice.

44 ent, that were significantly induced in PGRN null mice.

45 esis, we crossed DYT1 knock-in with p58(IPK)-null mice.

46 mammary fat pad of wild-type mice and Gpr81-null mice.

47 expression in the cortex of WT but not MMP-9-null mice.

48 wide expression of mutant ATXN1 and in ATXN1 null mice.

49 4.1B and betaII spectrin expression in Caspr-null mice.

50 rements confirm a thermogenic defect in NCLX-null mice.

51 ed adipose tissue lipid mobilization in CT-1 null mice.

52 is genes FASN and ACC1 is impaired in IQGAP1-null mice.

53 nction of this receptor in vivo using Jedi-1 null mice.

54 tion deficits observed in the Neurexophilin4 null mice.

55 similar to the protection observed in SARM1-null mice.

56 letal phenotypes similar to those of Cyp27b1-null mice.

57 adiponectin null mice, but not in T-cadherin null mice.

58 ficit or the cochlear abnormalities of BACE1 null mice.

59 type animals, but not in the retina of GPR81-null mice.

60 posure also was observed in the AM from RAGE null mice.

61 enotype seen in the cerebral cortex of Vldlr(null) mice.

62 in WT versus paranode defective (i.e., Caspr-null) mice.

63 ut not purified immunoglobulin, into obese B(null) mice.

64 ) (ATP binding cassette subfamily B member 4 null) mice.

65 lure of right ventricular formation in Hand2-null mice(4).

66 patients but distinct from those of miR-140-null mice(6).

67 crossed Idh1-KI mice with conditional Trp53 null mice, a well-characterized model of T-cell malignan

68 This effect was completely lost in the HCAR2-null mice after a 2-d starvation protocol, in which the

69 tion development gradually increased as PTEN null mice aged.

70 Here, AhR-null mice (AhR-/-) were used to explore whether AhR cont

71 or initiated, and consistent with this LRBA-null mice also demonstrate resistance to lethal GvHD.

72 ASPN-null mice also demonstrated a significant reduction in l

73 Interestingly, the null mice also displayed low serum phosphate levels, whi

74 Upf3b-null mice also have a profound defect in prepulse inhibi

75 omain of CIZ1 and the E repeats of Xist CIZ1-null mice, although viable, display fully penetrant fema

76 dney epithelial cells derived from both Pkd1-null mice and ADPKD patients.

77 ia, we engineered a novel strain of Nbce1b/c-null mice and assessed them for signs of pRTA.

78 tion of the mouse mammary gland in the Wasf3 null mice and brain development was normal.

79 the in vivo role of RTN1, we generated RTN1-null mice and compared the effects of RTN1 and RTN3 on B

80 We generated Zcchc8-null mice and found that heterozygotes, similar to human

81 explain the parturition differences in Cox-1 null mice and gestation-matched wild type (WT) controls.

82 In human beta-globin transgenic Eto2 null mice and in human CD34+ erythroid progenitor cells

83 t patterns downstream of single cones in Bax null mice and may serve to maintain constancy in both th

84 A and completely rescue both survival of Smn null mice and motor neuron electrophysiology demonstrati

85 ophages from heme overload in heme-loaded Hx-null mice and reduces production of cytokines and reacti

86 we investigated the bone phenotype in Bmpr1b null mice and the impacts of loss of Bmpr1b on osteoblas

87 By using intravital microscopy with DREAM-null mice and their bone marrow chimeras, we demonstrate

88 s clearance in NSG -( K(b) D(b)) (null) ( IA(null)) mice and NSG mice was comparable.

89 y higher tumorigenesis in NOD/Scid/IL2Rgamma-null mice, and immunostaining of mouse CD31 revealed tha

90 hasone responses were compromised in Angptl4-null mice (Angptl4(-/-)).

91 early death; on the other hand heterozygous null mice are apparently normal.

92 t from being prone to tumor development, Arf-null mice are blind, and their male germ cells exhibit d

93 conserved and is essential for life, as Dhps-null mice are embryonic lethal.

94 Fewer Wbp11 heterozygous null mice are found than expected due to embryonic and p

95 Moreover, because RIAM-null mice are healthy, fertile, and display no bleeding

96 Full-body Galpha(z)-null mice are protected from hyperglycemia and glucose i

97 Porcn-null mice are rescued from radiation lethality by treatm

98 D1 dopamine receptor (Drd1)-null mice are resistant to diet-induced obesity, metabol

99 Additionally, DDX58-null mice are resistant to the ability of dsRNA to inhib

100 dependent DAergic neurotransmission in RGS12-null mice are restricted to the nucleus accumbens.

101 Importantly, Wbp11 heterozygous null mice are small and exhibit defects in axial skeleto

102 increased chromosome instability, and Abro1-null mice are tumor-prone.

103 Scleraxis-null mice are viable and have a range of tendon and bone

104 display a reduced fetal size, whereas PRMT6 null mice are viable, which permits the generation of do

105 have been conducted in male Mecp2 hemizygous null mice as offspring of heterozygous dams.

106 duced G protein activation are seen in RGS12-null mice, as well as enhanced sensitivity to KOR agonis

107 We collected intestines from SHIP-null mice, as well as Inpp5d(+/+) mice (controls), and m

108 hmt (betaine-homocysteine methyltransferase)-null mice at age 4, 12, 24, and 52 wk (N = 8) and observ

109 d found to be significantly delayed in Cox-1 null mice at term.

110 nd elevated progesterone levels in the Cox-1 null mice at term.

111 In contrast, macrophages from ACE knockout (null) mice averaged only 28% of the ATP levels found in

112 TLR4 null and EDA null mice blocked Ad5.TGFbeta-induced ocular hypertensio

113 Lastly, mRNA from tuberous sclerosis-1/2-null mice brain tissue exhibiting ER stress had increase

114 rupts late-LTP and spatial memory in PKMzeta-null mice but not in wild-type mice.

115 adiponectin was also observed in adiponectin null mice, but not in T-cadherin null mice.

116 PF-06869206 had no effect on Npt2a-null mice, but promoted phosphate excretion and reduced

117 t delay in AML progression in NOD/SCID/IL2Rg(null) mice, but the persistence of adoptively transferre

118 Therefore, Xist-null mice can develop to term in spite of a deficiency o

119 Patients who lack PLP1 expression, and Plp1-null mice, can display comparatively mild phenotypes, su

120 Apoe null mice challenged with high-fat diet showed similar m

121 ity, were significantly increased in nAChRa7 null mice (Chrna7(-/-)) relative to wild-type mice.

122 unchanged in cultured DRG neurons from TrpC3 null mice compared to wild type.

123 observed increased plaque formation in CD47 null mice compared to wild-type controls.

124 MHCII(hi)-immune cells in tumors from Gpr81-null mice compared with tumors from wild-type mice.

125 Tumor growth was suppressed in Gpr81-null mice compared with wild-type mice.

126 of cell death in intestinal tissue of cIAP1-null mice, compared with wild-type C57BL/6 mice, cIAP2-n

127 e mTert gene in the first generation of Tert null mice compromised tumor growth, with reduced VEGF ex

128 nputs at end stages of disease (>/=P56 Mecp2 null mice) concomitant with synapse loss.

129 ysltr2 (-/-)) compared with WT and CysLT(1)R-null mice (Cysltr1 (-/-)).

130 cells are significantly reduced in CysLT(2)R-null mice (Cysltr2 (-/-)) compared with WT and CysLT(1)R

131 of IgG was studied using IgG mu heavy chain-null mice deficient in mature B cells and by IgG transfe

132 Ldlr(-/-) (low-density lipoprotein receptor null) mice deficient in miR-146a develop less atheroscle

133 Similar to SMGs from alpha3-null mice, deletion of alpha3 alleles in mSG-PAC1 cells

134 Finally, the hearts of VWF-null mice demonstrate an abnormal endothelial phenotype

135 Ptrh2 null mice demonstrate multiple degenerating and regenera

136 Homozygous null mice demonstrated significantly prolonged survival

137 gest attenuated oxidative stress in the RAGE null mice despite comparable CS exposure and lung leukoc

138 Here, we show that Atxn1-null mice develop a more severe experimental autoimmune

139 Krt16-null mice develop footpad lesions that mimic PC-associat

140 -null and haematopoietic hypocretin-receptor-null mice develop monocytosis and accelerated atheroscle

141 Lmna null mice develop these disorders and have a lifespan of

142 Instead, C9orf72 null mice developed progressive splenomegaly and lymphad

143 Strikingly, these conditional gp96-null mice developed spontaneous colitis, had increased l

144 our previous studies, we showed that Trim32 null mice developed Th2-biased skin inflammation in resp

145 In Pten;Trp53-null mice developing MM, the Galphai2-coupled receptor s

146 As Alpl-null mice die before weaning, we aimed to generate mouse

147 In the PNS of Caspr-null mice, diffusion trapping mediated by the NF186 ecto

148 Here we show that SUN2-null mice display cardiac hypertrophy coincident with en

149 We show that GPR55-null mice display decreased insulin sensitivity in these

150 fects, cortical pyramidal neurons from Upf3b-null mice display deficient dendritic spine maturation i

151 The miR-183/96/182 null mice display impairment of the visual, auditory, ve

152 Here we report that Naa10-null mice display partial embryonic lethality, growth re

153 ort that mice lacking Nogo receptors (NgR123-null mice) display complete CC agenesis due to axon misd

154 Similar to Rac1 knockouts, Cdc42 null mice displayed a severe loss of pigmentation, and m

155 Notably, Kv3.1-null mice displayed baseline hyperlocomotion, reduced an

156 ly, tumors growing in C/EBPalpha conditional null mice displayed greater MDSC infiltration, increased

157 Contrary to expectation, Cox-1 null mice displayed normal uterine contractility; theref

158 By 18 months of age, P2X7-null mice displayed phenotypic characteristics consisten

159 d macrophages (BMDMs) isolated from RORgamma-null mice displayed reduced capacity to secrete IL-1beta

160 NgR123-null mice displayed reduced motor coordination and hyper

161 of reeler mutants, while Reln(CTRdel)/Vldlr(null) mice do not.

162 y, expression of Mg29 in the hearts of Csrp3 null mice (encoding muscle LIM protein, MLP) partially r

163 sion only in GABAergic neurons of male Mecp2 null mice enhanced inhibitory signaling, extended lifesp

164 Unexpectedly, male UTX-null mice escape embryonic lethality due to expression o

165 urrent is absent in cochlear cells of Piezo2-null mice, even though the normal MT current persists.

166 Independent studies have shown that Sox3 null mice exhibit a spermatogenic block as young adults,

167 These Upf3b-null mice exhibit deficits in fear-conditioned learning,

168 Moreover, InSyn1 null mice exhibit elevated neuronal firing patterns in t

169 Axons of SARM1-null mice exhibit greatly delayed AxD after transection

170 We previously reported that RGS12-null mice exhibit increased dopamine transporter-mediate

171 nsistent with computational predictions, Id3-null mice exhibit increased numbers of cells expressing

172 oss of MyHC-emb function in vitro Adult Myh3 null mice exhibit scoliosis, a characteristic phenotype

173 Conversely, RGS12-null mice exhibited attenuated KOR-induced conditioned p

174 static synaptic scaling [3-6], but TNF-alpha-null mice exhibited no apparent cognitive or emotional a

175 P53-null mice expressing the MDMX(W) (200S/W201G) mutant, de

176 ly, in contrast to lamin A/C-null mice, SUN2-null mice fail to show coincident fibrosis or upregulati

177 Indirect calorimetry showed that Cyp2e1-null-mice fed FF exhibited consistently higher total ene

178 ls were cultured from wild-type and tryptase null mice, followed by an assessment of their profile of

179 We tested TrpC3 null mice for beta-alanine induced itch, and found that

180 advanced lung tumours from Kras(G12D/+);p53-null mice frequently exhibit Kras(G12D) allelic enrichme

181 The protection of Galpha(z)-null mice from HFD-induced diabetes is beta-cell autonom

182 Here, we find that in heterozygous gata3 null mice (gata3(+/-) ) outer hair cells (OHCs) differen

183 consistent with normal adipose mass in GPAT3-null mice, GPAT3 inhibition did not prevent the formatio

184 mice, whereas all WT mice survived, and Nrf2 null mice had a defect in clearance, particularly at the

185 Prostate tumor allografts in ASPN-null mice had a reduced number of tumor-associated MSCs,

186 Compared with wild-type mice, NgR123-null mice had a sharp increase in the glial marker glial

187 OLFM4 null mice had a significant 7-d survival benefit and les

188 Epithelial GR-null mice had elevated expression of proinflammatory che

189 The addition of I3C to the diet of AHR null mice had less of an impact than in AHR heterozygous

190 Claudin-18 null mice had significantly higher serum IgE levels and

191 At 12 months of age, P2X7-null mice had thickening of Bruchs membrane and retinal

192 ZnT8 null mice have a mild phenotype with a slight decrease i

193 In addition, neural stem cells from Upf3b-null mice have impaired ability to undergo differentiati

194 treated with anti-CD47 antibodies, and Cd47-null mice have impaired intestinal mucosal wound healing

195 Piezo2-null mice have largely normal hearing, exhibiting up to

196 Nbce1b/c-null mice have normal blood pH, but exhibit increased mo

197 ritical role in mammary gland function; ZnT2-null mice have profound defects in mammary epithelial ce

198 Our previous studies show that Shh null mice have smaller, aparathyroid primordia in which

199 In Ppara-null mice, hepatocyte Bcl6 ablation restores enhancer ac

200 The phenotype of Nbce1b/c-null mice highlights the physiologic importance of NBCe1

201 Female JDP2 null mice, however, exhibited early puberty, observed as

202 ge cells; early embryonic lethality in Bag-1 null mice, however, has limited the investigation of BAG

203 In Opn5-null mice, hyaloid vessels regress precociously.

204 ied evidence of partial lipoatrophy in Reep1 null mice in addition to prominent spastic paraparesis.

205 We used CD151-null mice in an in vivo model of IAV infection and clini

206 tudy was carried out with wild-type and CT-1 null mice in fed (ad libitum) and food-restricted condit

207 pR)-null, and melanocortin 4 receptor (MC4R)-null mice-in this study, we show that systemic celastrol

208 ctive prostasin are viable, unlike prostasin null mice, indicating that at least some prostasin funct

209 nocyte and fibroblast migration in the Rhamm-null mice, indicating that RHAMM suppresses keratinocyte

210 evated in the developing tooth germ of Smad7 null mice, indicating the hyperactivation of the canonic

211 Furthermore, crossing HSPB7 null mice into an Lmod2 null background rescued the elon

212 transplantation from platelet-specific ERK5 null mice into hyperlipidemic apolipoprotein E null mice

213 pite GC losses, retinal organization in Brn3 null mice is remarkably similar to that of wild-type con

214 ts from HFD-fed beta cell-specific Galpha(z)-null mice is significantly improved as compared with isl

215 n MDM2-ALT1 is ubiquitously expressed in p53 null mice it leads to increased incidence of spindle cel

216 We found that, unlike in WT mice, in Rhamm-null mice, keratinocyte migration initiates prematurely

217 or (VDR) only in the distal intestine of VDR null mice (KO/TG mice) results in the normalization of s

218 singly, damaged white matter tracts in Olig1-null mice lacked Olig2(+) OPCs, and instead proliferatin

219 docytopathy was completely preserved in MC1R-null mice, marked by reduced albuminuria and diminished

220 of pathology in dystrophic mice, dystrophin-null mice (mdx(betageo)) presented with a mildly exacerb

221 Reduced beta3 gene dosage in elastin-null mice mitigates pathological aortic muscularization,

222 The phenotype of Pierce1-null mice most closely resembled that of mutant mice wit

223 rmline liver fatty acid (FA) binding protein null mice (Mttp-LKO, i.e., double knockout mice) hepatic

224 cognitive impairment is not observed in tau-null mice or in mice treated with anti-tau antibodies, d

225 ophagy, but these effects are blunted in SHP-null mice or LSD1-depleted mice.

226 compared with wild-type C57BL/6 mice, cIAP2-null mice, or XIAP-null mice.

227 Finally, by crossing VPS35 KI and null mice, our data demonstrate that a single D620N VPS3

228 Consistent with these data, caveolin-1-null mice overexpressing K-Ras(G12D) display accelerated

229 eveloped in the embryos of Haao-null or Kynu-null mice owing to NAD deficiency.

230 gion, with 7 overlapping those found in Bhmt-null mice (P < 0.001).

231 ressor effect of I3C was not observed in Ahr null mice (P < 0.05).

232 autonomous, as beta cell-specific Galpha(z)-null mice phenocopy the full-body KOs.

233 ssue homeostasis, we generated germline PKM2-null mice (Pkm2(-/-)).

234 HSC aging and inflammation in young miR-146a-null mice, preceding development of aging-associated mye

235 tissues and intestinal macrophages from SHIP-null mice produced higher levels of IL1B and IL18 than i

236 imary tumor burden, Notch activation in Pten-null mice promoted epithelial-mesenchymal transition and

237 sfer experiments, matrix metalloproteinase-8 null mice receiving wild-type marrow had a survival adva

238 ric oxide synthase-deficient mice or alphaKL-null mice reduced serum phosphate levels.

239 ure rates are significantly delayed in TSG-6-null mice relative to wildtype mice.

240 Furthermore, MDM2-ALT1-expressing p53 null mice represent a novel mouse model of fusion-negati

241 sively in the somatosensory neurons of Mecp2-null mice rescues tactile sensitivity, anxiety-like beha

242 on of specific DNA loci in the liver of Bhmt-null mice results in repression of Iqgap2 and F2rl2 and

243 )-induced premature senescence in caveolin-1-null mice results in the formation of more abundant lung

244 Conversely, GPR81-null mice retina shows reduced inner vascular network fo

245 the fasting response in wild-type and IQGAP1-null mice revealed that transcriptional regulation of th

246 lysis of both male and female maternal Ube3a-null mice reveals that microcephaly in the AS mouse mode

247 In RTN3-null mice, RTN1 expression was slightly elevated.

248 We suggest Upf3b-null mice serve as a novel model system to decipher cell

249 Emd null mice show no overt pathology and have normal skelet

250 Opn5-null mice show overactive BAT, increased body temperatur

251 Experiments in Fmr1 null mice show that FMRP regulates axonal protein expres

252 Furthermore, Prkcz null mice showed compromised AD-like phenotypes in the M

253 ll mice into hyperlipidemic apolipoprotein E null mice showed decreased platelet accumulation and inc

254 g-term pressure overload both Atf6 and Atf6b null mice showed enhanced decompensation typified by inc

255 ively in OCs (CtskCreRor2 (fl/fl) ) in Sfrp4 null mice significantly reversed the increased number of

256 We find that Slc44a2 null mice (Slc44a2(KO)) have increased bleeding times an

257 We used wild-type and Olig1-null mice subjected to neonatal stroke and postnatal neu

258 orotic phenotype that is very similar to opg-null mice, suggesting that the antiresorption activity o

259 Surprisingly, in contrast to lamin A/C-null mice, SUN2-null mice fail to show coincident fibros

260 ium-phosphate cotransporter Npt2a in alphaKL-null mice supporting direct actions of cKL in the absenc

261 s, we exploited humanized NOD-scid IL2rgamma(null) mice systemically infected with HIV-1 to generate

262 e to death was significantly faster in PTPN7-null mice than in WT mice in a pulmonary thromboembolism

263 etory stage of amelogenesis, utilizing Mmp20-null mice that lack this essential protease.

264 ree different atherosclerosis models in ApoE null mice that prolonged systemic treatment with LyP-1 t

265 ted, streptozotocin-treated ghrelin receptor-null mice that were administered GcgR monoclonal antibod

266 In null mice, the prevention of NAD deficiency during gesta

267 Compared with Csf1r-null mice, the skeletal and neural phenotypes of the aff

268 Ldlr(-/-) (low-density lipoprotein receptor null) mice transplanted with bone marrow (BM) cells from

269 Gjb1-null mice treated with LV-Mpz.GJB1 compared with LV-Mpz.

270 efects that rendered adipose-specific PGRMC2-null mice unable to activate adaptive thermogenesis and

271 human IL-2 to NSG -( K(b) D(b)) (null) ( IA(null)) mice via adeno-associated virus vector increased

272 r formation observed in p53(5KR/5KR) and p53-null mice was suppressed upon the treatment of the mTOR

273 eveloped in p53 wild-type ((+/+)) versus p53 null ((-/-)) mice, we observed higher GMPS expression in

274 intrathecal injection into 6-month-old Gjb1-null mice, we confirmed expression of Cx32 in lumbar roo

275 tor, nitrobenzylthioinosine (NBTI), and ENT1-null mice, we demonstrated that ENT blockade elevated lu

276 Here, using male wildtype (WT) and Pxr-null mice, we examined PXR-mediated regulation of chroni

277 Using arrhythmic Bmal1-null mice, we generated animals with reconstituted circa

278 ased delta opioid receptor activity in Gpr88 null mice, we investigated the impact of GPR88 co-expres

279 Using MMP9- and MMP13-null mice, we observed no discernible effects of each pr

280 Msh2-null mice were also impaired in locomotive activity and

281 Gm15441-null mice were developed and shown to be more susceptibl

282 Male wild-type (WT) and Cyp2e1-null mice were fed standard chow or FF for 2, 12, and 24

283 Plaa-null mice were generated and prostaglandin E2 levels wer

284 Plaa-null mice were perinatal lethal with reduced brain level

285 elinated corpus callosum projections of Msh2-null mice were smaller than wild-type mice, whereas unmy

286 ctor-erythroid 2 p45-related factor 2 (Nrf2) null mice were studied.

287 Wild-type (WT) C57Bl/6 and OLFM4 null mice were subjected to intestinal IR injury and the

288 NOD-Scid-IL2Rgamma null mice were transplanted with human hematopoietic CD3

289 ysosomes in the gastric epithelium of trpml1-null mice, where they are protected from eradication the

290 an IgG clearance in NSG- B2M(null) ( IA IE) (null) mice whereas clearance in NSG -( K(b) D(b)) (null)

291 gly increased from 15 to 31 and 100% in Nrf2 null mice, whereas all WT mice survived, and Nrf2 null m

292 elay in the onset of prostate cancer in Pten-null mice, whereas Kdm5b loss alone caused no morphologi

293 n primary murine chondrocytes from A2AR(-/-) null mice, which develop spontaneous OA by 16 weeks, the

294 Similar to P4ha1 null mice, which die prenatally, the muscle tissue from

295 the complex pathological phenotypes of FUT8 null mice, which display defects in cellular signaling,

296 se to VRS using TRPV1 antagonism or in Trpv1 null mice while the response to passive stretch remains

297 ng hormone axons was reduced in adult Magel2-null mice, while the density of orexigenic agouti-relate

298 alphaKL-null mice with sustained AAV-cKL expression had a 74%-78

299 wed greater sensitivity to NA than Cyp2abfgs-null mice, with greater depletion of nonprotein sulfhydr

300 trials, increased the survival of Pten;Trp53-null mice without major toxicity.