ライフサイエンスコーパス: null mouse

1 l only in the acute liver-specific Hnf4alpha-null mouse.

2 in a neural cell line derived from a PrP(C)-null mouse.

3 7(rsq1) is a bona fide phenocopy of the TLR7 null mouse.

4 create the hepatic microsomal cytochrome b5 null mouse.

5 ment were examined using a conditional Wnt7b-null mouse.

6 bed the generation of a mast cell protease-6-null mouse.

7 nce of Nodal reported in the LPM of the Pkd2-null mouse.

8 sion to alleviate dystrophy in the delta sgc-null mouse.

9 created a conditional and cell-specific TLR null mouse.

10 in the vascular endothelial cells of the Ace null mouse.

11 exclusively in a single cell type of an Ace null mouse.

12 hese alterations are reproduced in the Kv1.1-null mouse.

13 AFP repression during development of the p53-null mouse.

14 frontal cortex of the dopamine D(1) receptor null mouse.

15 gy of NCB5OR and the phenotype of the Ncb5or-null mouse.

16 nd imbalanced glucose metabolism in the Igf2 null mouse.

17 alabsorption and, more recently, by the Pcft-null mouse.

18 o the affected brain areas in the myorg PFBC null mouse.

19 cantly elevated in the kidneys of the miR-22 null mouse.

20 increased in the processing-deficient (PC1/3 null) mouse.

21 and mast cell degranulation in the annexin 1(null) mouse.

22 for comparison, a fully EXO1-deficient (Exo1(null)) mouse.

23 periodontal defect was observed in the Dmp1 null mouse, a mouse model of hypophosphatemic rickets.

24 g cells, we examined secretion from Munc18-1-null mouse adrenal chromaffin cells expressing Munc18-1

25 In turn, anomalies of the p63-null mouse affecting the skin and skeleton are partially

26 n two genetic models of hemochromatosis (HFE-null mouse and HJV-null mouse) and in two nongenetic mod

27 Here, we generate an Ift25 null mouse and show that IFT25 is not required for cilia

28 reduced during early lactation in the AFAP1-null mouse and the localization of active cSrc at the ap

29 s of hemochromatosis (HFE-null mouse and HJV-null mouse) and in two nongenetic models of iron overloa

30 ly detected abnormal remodeling in the Cox-1 null mouse, and clearly demonstrated that the cervix pla

31 ekly beginning at 6-7 weeks in the NPC1(-/-) null mouse, and delivery of the plasmid DNA, and NPC1 mR

32 E), including the reversal of the caveolin-1-null mouse angiogenic phenotype.

33 y expressing human apoE3 or human apoE4 on a null mouse apoE background revealed that apoE4 expressio

34 s and lack of a cancer phenotype in the TP73 null mouse are inconsistent with a suppressor function b

35 on in a 'self-terminating' Atoh1 conditional null mouse (Atoh1-Cre; Atoh1(f/f)).

36 When expressed in Snap-25-null mouse autaptic neurons, region I mutations reduced

37 in RAW264.7 cells as well as the use of Hsf1 null mouse bone marrow cells demonstrated that 17-AAG-en

38 ry Mk cells from cultures initiated with p53-null mouse bone marrow mononuclear cells displayed highe

39 e MKS3, we analyzed phenotypes in the Tmem67 null mouse (bpck) and in zebrafish tmem67 morphants.

40 In the NG2 null mouse brain, pericyte investment of the tumor vascu

41 d in the maturation stage enamel of the Klk4 null mouse, but not in the Klk4 heterozygous or wild-typ

42 Studies with TIMP-3-null mouse cartilage indicated that CaPPS inhibition of

43 ve shown that mTOR is hyperactivated in Pkd1-null mouse cells due to failure of the HGF receptor c-Me

44 ane fusion can be readily visualized in OPA1-null mouse cells in vivo, but these events do not progre

45 rmal human mammary epithelial cells or STAT3-null mouse cells.

46 phological and proliferative defects of PFN1 null mouse chondrocytes.

47 d-type mouse colon but not in Pparbeta/delta-null mouse colon.

48 d luminal content was more acidic in slc26a3-null mouse colon.

49 Here, we report that presenilin-1 (PS1) null mouse cortical neuronal cultures have increased amo

50 Mecp2-null mouse cortical neurons have diminished Na(+),K(+)-A

51 By 6 mo of age, the Pkhd1-null mouse develops massive cystic hepatomegaly and prox

52 a7beta1 integrin expression in the delta sgc-null mouse did not alleviate muscular dystrophy in these

53 A CerS2 null mouse displays hepatopathy because of depletion of

54 f ADAR in PyV infection, we used genetically null mouse embryo fibroblast cells deficient in either A

55 , by using purified soluble Pref-1 in Pref-1 null mouse embryo fibroblasts (MEF), we show that Pref-1

56 target gene RAR-beta2 are impaired in ASC-2-null mouse embryo fibroblasts (MEFs) or in MEFs expressi

57 RIG-I null mouse embryo fibroblasts (MEFs) retained the abilit

58 yl oxidase is much reduced in cultures of FN-null mouse embryo fibroblasts (MEFs).

59 d in Tgif1; Tgif2-null embryos and in double-null mouse embryo fibroblasts (MEFs).

60 Egr1-null mouse embryo fibroblasts bypass replicative senesce

61 We conclude that late passage IGF-I receptor null mouse embryo fibroblasts can be transformed by SV40

62 SSeCKS-null mouse embryo fibroblasts displayed increased relati

63 DR5-null mouse embryo fibroblasts expressing E1A are resista

64 es of wild-type and HIF-1alpha- or AMPKalpha-null mouse embryo fibroblasts to determine whether AMPK

65 result from the loss of Pin1 predispose Pin1 null mouse embryo fibroblasts to undergo more rapid geno

66 ifferentiation of 3T3-L1 cells and in Pref-1-null mouse embryo fibroblasts transduced with Pref-1A.

67 with >2-fold differential expression in Egr1-null mouse embryo fibroblasts, including 143 known genes

68 ngth is also calcium-insensitive in gelsolin-null mouse embryo fibroblasts.

69 cell lines and fibroblasts derived from TACE-null mouse embryo.

70 H-beta by short hairpin RNA and P4H-alpha(I) null mouse embryonic fibroblast cells showed reduced sta

71 When transfected into PLC-gamma1-null mouse embryonic fibroblast cells, catalytically act

72 ure senescence are compromised in caveolin-1 null mouse embryonic fibroblasts (MEF).

73 Ajuba null mouse embryonic fibroblasts (MEFs) and lungs were d

74 ression was severely abrogated in C/EBP-beta-null mouse embryonic fibroblasts (MEFs) and primary C/EB

75 ne 27 trimethylation (H3K27me3) in both Pten null mouse embryonic fibroblasts (MEFs) and Pten null mo

76 compare the gene expression profiles of Pten null mouse embryonic fibroblasts (MEFs) cell lines and t

77 ly per unit length over mitochondria in Drp1-null mouse embryonic fibroblasts (MEFs) compared to wild

78 st-induced NFAT activation is reduced in p65 null mouse embryonic fibroblasts (MEFs) compared with wi

79 Indeed, ASC-2-null mouse embryonic fibroblasts (MEFs) have been demons

80 genes, we compared gene expression in STAT3-null mouse embryonic fibroblasts (MEFs) stably expressin

81 NA damage, we exposed wild-type and PKCdelta null mouse embryonic fibroblasts (MEFs) to UV radiation.

82 also reduced in Ras(V12)-expressing p19(Arf) null mouse embryonic fibroblasts (MEFs), and overall Egr

83 Activation of GSK-3 in Keap1-null mouse embryonic fibroblasts (MEFs), or in human lun

84 Similarly, in Kif3a null mouse embryonic fibroblasts (MEFs), the overall Ton

85 ore and after oxidative stress in caveolin-1-null mouse embryonic fibroblasts (MEFs), which do not ex

86 e senescence in wild-type but not caveolin-1 null mouse embryonic fibroblasts (MEFs).

87 Using Src, Yes, and Fyn null mouse embryonic fibroblasts (SYF cells), we show th

88 CDC3 expression is markedly reduced in TAp63-null mouse embryonic fibroblasts and brown adipose tissu

89 nscription assays were performed with IQGAP1-null mouse embryonic fibroblasts and HEK293 cells with I

90 Using ectopic expression studies in p53-null mouse embryonic fibroblasts and p53/PTEN-null PC3 c

91 well as STAT3 activation, we examined STAT5-null mouse embryonic fibroblasts and primary hepatocytes

92 Knockdown of GRB10 in nontumorigenic PTEN null mouse embryonic fibroblasts and tumorigenic PCa cel

93 d the spontaneous transformation of MdmX/p53-null mouse embryonic fibroblasts in vitro and with an in

94 ion, we showed that the loss of RNPC1 in p53-null mouse embryonic fibroblasts leads to reduced expres

95 ver, inhibition of deregulated TORC1 in TSC2-null mouse embryonic fibroblasts or in 293 cells by down

96 SIRT3-null mouse embryonic fibroblasts produced significantly

97 HDAC6-null mouse embryonic fibroblasts rescued by the nonphosp

98 ng-deficient mutants of vinculin in vinculin-null mouse embryonic fibroblasts revealed that PIP2 bind

99 d Ca(2+) imaging experiments with presenilin-null mouse embryonic fibroblasts to analyze ER Ca(2+) le

100 Here, we use wild-type and vimentin-null mouse embryonic fibroblasts to show that VIFs regul

101 E2F4-null mouse embryonic fibroblasts were less sensitive tha

102 In autophagy-deficient Atg5 or Atg3 null mouse embryonic fibroblasts, OFD1 accumulates at ce

103 Genotoxic-stressed ATF3-null mouse embryonic fibroblasts, or cells in which ATF3

104 cally expressed in oxidatively stressed OGG1-null mouse embryonic fibroblasts, suggests that acetylat

105 Furthermore, in FN-null mouse embryonic fibroblasts, we observed dramatical

106 junction (HJ) resolution activity in Rad51c-null mouse embryonic fibroblasts, we propose that this l

107 Using fibronectin-null mouse embryonic myofibroblasts, we identified a nov

108 ddress biology we previously generated trex2(null) mouse embryonic stem (ES) cells and expressed in t

109 performed a microarray analysis using Mef2c-null mouse embryos and identified a novel MEF2-regulated

110 Wt1-null mouse embryos develop CDH but the mechanisms regula

111 ution of prostaglandins from the uterus: COX null mouse embryos develop normally during embryogenesis

112 Moreover, we report that LEC-specific Reln-null mouse embryos develop smaller hearts, that RELN is

113 Although all Jun null mouse embryos die at mid-gestation with persistent

114 ssential for mouse development, as most Bmp4-null mouse embryos die at the onset of gastrulation and

115 Nkx2-5(-/-) null mouse embryos display severe OFT and RV hypoplasia

116 ome, which commence early in gestation, MMP9-null mouse embryos exhibit deficiencies in trophoblast d

117 Here we show that CLIC4-null mouse embryos exhibit impaired renal tubulogenesis.

118 Ndst1-null mouse embryos exhibited different degrees of phenot

119 In this report, we show that Frs2alpha-null mouse embryos have a defect in anterior-posterior (

120 Loss of muscle mass in Ihh null mouse embryos is accompanied by a dramatic increase

121 By contrast, Pou5f1-null mouse embryos maintained the expression of ortholog

122 Here, we show that removal of Gli3 in Ihh-null mouse embryos restored normal proliferation and mat

123 tient cells, and in tissues from Flna(Dilp2) null mouse embryos results in cellular phenotypes identi

124 Our studies using Akt1 null mouse embryos show a reduction in p-eNOS((S1177)) e

125 Accordingly, p63 null mouse embryos show marked cochlea abnormalities, an

126 Additionally, Barx1 null mouse embryos show visceral homeosis, with intestin

127 y in Xenopus as well as the analysis of Dkk1-null mouse embryos transform the anterior neural fold in

128 ity partially rescued the phenotypes in Chd7-null mouse embryos, demonstrating that p53 contributes t

129 In constitutive Pcdh-gamma null mouse embryos, many interneuron populations undergo

130 from chromatin remodeling ATPase LSH (HELLS)-null mouse embryos, which lack DNA methylation from cent

131 unctions in vivo, we have generated Aurora A null mouse embryos, which show severe defects at 3.5 d.p

132 r patterning present in Sonic hedgehog (Shh) null mouse embryos.

133 ippocampal neurons from wild-type and Ctnnd2 null mouse embryos.

134 Strikingly, the Mmp20 null mouse enamel organ morphology is noticeably dysplas

135 portance of UTX in bivalency resolution, Utx-null mouse ESCs and UTX-depleted NT2/D1 cells displayed

136 ssion of the Bcl2l1 transgene into PKC-theta null mouse failed to rescue NKT cell development.

137 c-myb-null mouse fetuses lack definitive erythrocytes but cont

138 Fog2 null mouse fetuses or fetuses homozygous for a targeted

139 Sox6-null mouse fetuses present misshapen and nucleated eryth

140 Here we show that pol lambda null mouse fibroblasts are hypersensitive to oxidative D

141 pression of mutated caveolin-1 in caveolin-1-null mouse fibroblasts failed to induce formation of cav

142 ular BER capacity, in wild-type and beta-pol null mouse fibroblasts, was next ascertained.

143 Using PKR inhibitors and PKR null mouse fibroblasts, we verified that ethanol-induced

144 ed to correct the vacuolar phenotype of Fig4-null mouse fibroblasts.

145 ack of cell surface cadherin 11, cadherin 11-null mouse FLS cells still formed intimate cell-cell con

146 Adamts1 mRNA was absent in the ADAMTS1 null mouse frontal cortex, but there was no change in th

147 knockdown of miR-491-5p in primary Ink4a-Arf-null mouse glial progenitor cells exacerbated cell proli

148 essing cone structure and function in Gbeta3-null mouse (Gnb3(-/-)).

149 Although the Col6a1(-/-) null mouse has an extremely mild neuromuscular phenotype

150 Echocardiography of Mybphl heterozygous and null mouse hearts exhibited a 36% reduction in fractiona

151 However, MLP-null mouse hearts had 1.2-fold higher LV-to-body weight

152 eat-containing E3 ubiquitin protein ligase 1-null mouse hearts was associated with increased PLN leve

153 -type and myosin-binding protein C (cMyBP-C)-null mouse hearts.

154 emic functional recovery in WT but not in AR-null mouse hearts.

155 ts performed using pregnane X receptor (PXR)-null mouse hepatocytes revealed that EFV-mediated XBP1 s

156 processed CRS4C in protein extracts of MMP-7-null mouse ileum demonstrates the in vivo requirement fo

157 ed in a dose-dependent phenocopy of the Tbx1 null mouse including loss of caudal pa and pharyngeal ar

158 ein complex-lacking Scgd (delta-sarcoglycan) null mouse, indicating that dysferlin functionality is n

159 Breeding of Kbtbd5 null mouse into the E2F1 null background rescues the let

160 The CD36-null mouse is protected from diet-induced weight gain bu

161 Leptin secretion in the CD36-null mouse is strongly responsive to glucose intake, whe

162 Embryonic survival of this zeta-null mouse is variable and strongly influenced by geneti

163 ts of Ca(2+) dynamics in wild-type and Kv2.1 null mouse islets.

164 ified 155 that reduced the viability of Pkd1-null mouse kidney cells with minimal effects on wild-typ

165 s reduced throughout collecting ducts of AE1-null mouse kidney, where increased fractional excretion

166 It was reported previously that Pkd1(null/null) mouse kidney epithelial cells are unresponsive to

167 mental defects of TRAF6- and integrin alpha3-null mouse kidneys are similar.

168 Thus, VX-809 treatment of pkd1-null mouse kidneys significantly affected CFTR, NHE3, an

169 erized a genuine estrogen receptor (ER) beta-null mouse line (named ERbeta(ST)(L-/L-)) and showed tha

170 In this study, we characterized Spns2-null mouse line carrying the Spns2(tm1a(KOMP)Wtsi) allel

171 We have made a true RGS7-null mouse line with exons 6-8 deleted.

172 A null mouse line, stra6 -/-, was generated.

173 Arhgef5 were investigated using an Arhgef-5-null mouse line.

174 Comparison of wild-type and p53-null mouse liver tissue by using chromatin immunoprecipi

175 immunoprecipitation assays of normal and p53-null mouse liver tissue showed that TA-p73 binds at a pr

176 bserved in the sphingolipid profile of CerS2 null mouse liver, including elevated C16-ceramide and sp

177 hallenged wild-type (WT), TrxR1-null, or Gsr-null mouse livers exhibited similarly low DNA damage ind

178 otein levels in wild-type, but not PPARalpha-null, mouse livers, with no changes in HNF4alpha mRNA.

179 Cd151-null mouse lung endothelial cells (MLECs) showed normal

180 endothelial cell deficiency, isolated CD151-null mouse lung endothelial cells showed diminished supp

181 n to extracellular matrix deposited by CD151-null mouse lung endothelial cells.

182 Studies revealed that Ahr-null mouse lung tissue had a 4-fold increase in AhR-medi

183 e confirmed in vivo using wild type and cd73 null mouse lung tissue.

184 in this process by complementation of Bard1-null mouse mammary carcinoma cells.

185 ESPL1 RNA was also increased in p53-null mouse mammary cells in vivo by 18 h of hormone stim

186 The p53 null mouse mammary epithelial transplant model is charac

187 Using a syngeneic p53-null mouse mammary gland tumor model that closely mimics

188 mmary tumors derived from transplantable p53 null mouse mammary outgrowth lines revealed significant

189 Furthermore, this p53-null mouse mammary tumor model may allow us to identify

190 , we demonstrate that TICs isolated from p53 null mouse mammary tumors repair DNA damage following in

191 mammary epithelial cells isolated from Cav-1 null(-/-)/mouse mammary tumor virus-CR-1 transgenic anim

192 se line, expressing the human MAPT gene in a null mouse Mapt background.

193 in invertebrates and suggest that the Dlgh-1 null mouse may be a useful animal model to study certain

194 pathogenesis in a RTT mouse model, the Mecp2 null mouse (Mecp2(tm1.1Bird/y)).

195 D, with distinct defects from both the Aipl1-null mouse mimicking LCA and the Aipl1-hypomorphic mice

196 esis, we analyzed tooth development in a Bsp null ((-/-)) mouse model.

197 To date, only one null mouse model (A7KO) is available which is non-condit

198 ion in adult skeletal muscle using a cMyBP-C null mouse model (cMyBP-C((t/t))).

199 Phi) by creating a MPhi-specific GH receptor-null mouse model (MacGHR KO).

200 s question, we used a conditional p16(INK4a) null mouse model and determined the impact of p16(INK4a)

201 Here we show that a Magel2 null mouse model and fibroblast cell lines from individu

202 To this end, we used a cPLA2alpha-null mouse model and found that cPLA2alpha has a signifi

203 O(6)MeG-dependent apoptosis, we used an Mgmt-null mouse model combined with either the Msh6-null muta

204 Importantly, the Igf2 null mouse model does not represent a simple delay of gr

205 In accordance, cells derived from a parkin-null mouse model exhibited increased levels of cyclin D1

206 omplete ablation of Dicer activity in a Pten null mouse model for prostate cancer significantly halts

207 Our findings using a VGLUT2 conditional-null mouse model indicate that glutamate is essential fo

208 Using a syngeneic TP53-null mouse model of breast cancer, we identified distinc

209 re neuromuscular pathology seen in the Lama2-null mouse model of MDC1A.

210 Dietary restriction does not affect a PTEN-null mouse model of prostate cancer, but it significantl

211 This CD null mouse model provides a tool to explore the in vivo

212 An SRC-1-null mouse model reveals that the mouse SRC-1 gene has a

213 this scar analysis approach, a fibromodulin-null mouse model that heals with increased scar was also

214 Additionally, we use a Sox3 null mouse model to define a potential role for this fac

215 Here, we used our calpain-1 null mouse model to evaluate the function of calpain-1 i

216 create a targeted tendon and ligament Col5a1-null mouse model, Col5a1(Deltaten/Deltaten).

217 pecifically designed Drosha-null/conditional-null mouse model, generated using the conditional by inv

218 Using a Mta-1 null mouse model, here we provide genetic evidence to su

219 resent results of a study using a novel GHSR-null mouse model, in which ghrelin administration fails

220 ific ligand (L165041) and the PPARbeta/delta-null mouse model, that PPARbeta/delta enhances postnatal

221 Thus, utilizing this Mta1-null mouse model, we identified a distinct contribution

222 C-MS)-based metabolomics platform and Cyp2e1-null mouse model.

223 and prevents photoreceptor death in the Bbs4-null mouse model.

224 utes to the increased mortality in the FGF23-null mouse model.

225 a CCAAT/enhancer binding protein (C/EBPbeta)-null mouse model.

226 been prevented by the lack of a Cav-1 (-/-)-null mouse model.

227 munodeficient IL2 receptor gamma (IL2rgamma)-null mouse model.

228 tion of Rbm38 in vivo, we generated an Rbm38-null mouse model.

229 the potential use of the NOD-scid IL2rgamma(null) mouse model to evaluate vaccine safety and further

230 ion, we used the humanized NOD/SCID/gamma(c)(null) mouse model, which becomes populated with human B

231 aftment potential in the NOD/SCID/IL2Rgamma2(null) mouse model.

232 cell lymphoma in a xenogeneic NOD/SCID/IL2rg(null) mouse model.

233 utilized conditional expression and genetic-null mouse models of Spry1 in adipocytes using the fatty

234 To address this question, we generated H3.3-null mouse models through classical genetic approaches.

235 Here, we have used Scn1b null mouse models to understand better the relation betw

236 K8 overexpression, and K8-null or K18-null mouse models, indicate that a K8-greater-than-K18 e

237 bserved in immune cells cultured from Samhd1 null mouse models, these mice are physically healthy, sp

238 Using multiple sarcoglycan null mouse models, we show that loss of alpha-sarcoglyca

239 microscope level were unchanged in either Cx null mouse models.

240 ormalities similar to those seen in complete null mouse models; however, these occur at a later time

241 COX-2-null mouse Muller cells treated with increasing concentr

242 Meiob-null mouse mutants exhibit a failure in meiosis and ster

243 ent, based on clinical score, of conditional null mouse mutants lacking S1P(1) in CNS cell lineages a

244 AFM in Vcl heterozygous null mouse myocytes showed a significant decrease in mem

245 In the math1 null mouse, neuroblasts never populate the external germ

246 analyzed subcellular transcriptomes of FMRP-null mouse neuronal cells to identify transcripts that d

247 erating a megakaryocyte lineage-specific FAK-null mouse (Pf4-Cre/FAK-floxed).

248 rocarbon core nanoparticles (PFC-NP) in ApoE null mouse plaques with [(19)F] magnetic resonance spect

249 d secretion responses were diminished in HS1-null mouse platelets after stimulation of GPVI and prote

250 Both Pfn1-null mouse platelets and platelets isolated from WAS pat

251 duced platelet functional responses in GIRK2-null mouse platelets, suggesting that functional channel

252 and hair phenotype of a whole-body PPARgamma-null mouse (Pparg(Delta/Delta)), obtained by preserving

253 Importantly, FABP4-null mouse preadipocytes as well as macrophages exhibite

254 5) in tooth development using laminin alpha5-null mouse primary dental epithelium and tooth germ orga

255 We used the Pten-null mouse prostate cancer model to investigate the func

256 mouse embryonic fibroblasts (MEFs) and Pten null mouse prostate tissues.

257 gression might be activated in indolent Pten-null mouse prostate tumours and that inactivation of suc

258 e upon genetic deletion of Smad4 in the Pten-null mouse prostate.

259 after adoptive transfer into NOD scid gammac(null) mouse recipients, verifying the effects in vivo.

260 esults in embryonic lethality, the calpain-1 null mouse remains the only experimental model available

261 of either Msh6 or Exo1 function in the Mgmt-null mouse renders these rapidly proliferating tissues a

262 , ShH10, transduces Muller cells in the Dp71-null mouse retina efficiently and specifically (2,3).

263 Myo7a-null mouse retinas and purified RPE melanosomes were ana

264 V-null, CA XIV-null, and CA IV/CA XIV-double-null mouse retinas.

265 cological and behavioral studies in the D(1) null mouse should be interpreted in the context of possi

266 Thy-1, we discuss the phenotype of the Thy-1 null mouse, signaling pathways modulated by Thy-1, the r

267 Furthermore, Ras-transformed p53- and Cry-null mouse skin fibroblasts are more sensitive than p53

268 COX-2) is significantly greater, in PPARbeta-null mouse skin in response to TPA compared with wild-ty

269 oxidative stress in keratinocytes from Krt16 null mouse skin, a model for pachyonychia congenita (PC)

270 l-13-acetate (TPA) as compared with PPARbeta-null mouse skin.

271 his study, we show that MSUC occurs in Spo11-null mouse spermatocytes with extensive asynapsis but la

272 control and carcinogenesis, we used a Cdc25A-null mouse strain we recently generated.

273 in-2 receptor-gamma-null (NOD-SCID IL2Rgamma(null)) mouse strain that expressed human stem cell facto

274 ure ghrelin in various prohormone convertase null mouse strains generated in our laboratory and have

275 ls and patterns are not altered in the SPARC null mouse, suggesting that SC1 does not compensate for

276 ntly generated a ceramide synthase 2 (CerS2) null mouse that cannot synthesize very long acyl chain (

277 Therefore, we generated a GPC1 null mouse that combines pancreas-specific Cre-mediated

278 A functional alpha2delta2-null mouse, the ducky mouse (du), showed elevated audito

279 luble extracts from various C57BL/6J and Ahr-null mouse tissues were also analyzed for the presence o

280 ific alterations of mtDNA copy number in ATM null mouse tissues, the latter being recapitulated in ti

281 The present study used an Aldh1a1 null mouse to assess the influence of ALDH1A1 on the fun

282 We have used the Tbx1 null mouse to understand the tooth phenotype reported in

283 ability of the use of the NOD-scid IL2rgamma(null) mouse to study osteoarticular brucellosis and exam

284 A liver-Cpr-null mouse was also studied to test whether hepatic P450

285 A Wfdc1-null mouse was generated to assess core functions.

286 as caused by EP1 receptor inhibition, an EP1-null mouse was generated using a "hit-and-run" strategy

287 The Sonic hedgehog (Shh)-null mouse was initially described as a phenotypic mimic

288 The enamel layer in the Klk4 null mouse was normal in thickness and contained decussa

289 The lung-Cpr-null mouse was studied to resolve whether pulmonary P450

290 er the role of STAT1, a corresponding STAT-1-null mouse was used.

291 glia to spongiform degeneration in the Fig4 null mouse, we expressed Fig4 under the control of the n

292 transduced embryonic fibroblasts from a CSL-null mouse, we generated cell lines that express either

293 ific epidermal growth factor receptor (EGFR) null mouse, we show that exendin-4 induced an increase i

294 Finally, using a Sox1-null mouse, we show that the formation of this Sox2/Sox9

295 o occurred in a lead-treated metallothionein-null mouse, whereas none occurred in WT mice.

296 SFRP1 (secreted frizzled-related protein-1)-null mouse, which exhibits activated WNT signaling and a

297 Leptin levels are doubled in the CD36-null mouse, which has impaired cellular fatty acid uptak

298 aling by using a ceramide synthase 2 (CerS2) null mouse, which is unable to synthesize very long acyl

299 Here, we report a Tbx22(null) mouse, which has a submucous cleft palate (SMCP) a

300 manner, and have attempted to rescue the Ihh-null mouse with the Gli2 activator, either alone or in c