ライフサイエンスコーパス: numbering

1 F(2495), NPLY(2519), and DPF(2534) (315-HARE numbering).

2 serine protease domain (G216 in chymotrypsin numbering).

3 idues 184A, 185, 221A, and 224 (chymotrypsin numbering).

4 esidues 148, 348, 404, and 504 (ovine PGHS-1 numbering).

5 is located at position 290 (Escherichia coli numbering).

6 ), 226(M1), and 254(M2) (using alpha subunit numbering).

7 e Ile16-Asp194 salt bridge (chymotrypsinogen numbering).

8 n the loop at position 159 (Escherichia coli numbering).

9 pped by MCPF-CoA as Cys-114 (mature sequence numbering).

10 , 699, 703, and 710 (chicken skeletal myosin numbering).

11 thylation of residue G2470 (Escherichia coli numbering).

12 ally conserved "perturbing" Lys-194 (E. coli numbering).

13 S(1) pocket (position 189, chymotrypsinogen numbering).

14 ine of the TrkA domain (Y785 in TrkA residue numbering).

15 288L/F290V (all mutants given T. californica numbering).

16 3 and by the residue at position 119 (CYP4A3 numbering).

17 vative substitutions (N291G and P294K; human numbering).

18 enosine-1518 and -1519 (all Escherichia coli numbering).

19 he residue at position 192 (chymotrypsinogen numbering).

20 putative catalytic Glu-458 (Escherichia coli numbering).

21 on the 39-loop of the protease (chymotrypsin numbering).

22 igosaccharide side chain at position 146 (N2 numbering).

23 s at positions 27, 31, and 34 (based on ChTX numbering).

24 been deleted (TolR(62-133), Escherichia coli numbering).

25 mutated in silico to PVVV (P407V in the 2A79 numbering).

26 residues 81 to 83 and 117 to 122 of HA1 (H5 numbering).

27 with conserved Arg122 (PfDHFR-TS amino acid numbering).

28 d residue for ATP contact is Lys(6)(9) (P2X2 numbering).

29 (superscripts refer to Ballesteros-Weinstein numbering).

30 contributions at positions 37 and 69 (pcDHFR numbering).

31 the non-hydrogen-bonded Val 38 (eubacterial numbering).

32 e are straightforward based on the universal numbering.

33 STVs are associated with anomalous vertebral numbering.

34 om a population of citizens aged >/=50 years numbering 1.71 million in 2000 and 1.87 million in 2010

35 Roma (numbering 6 million) and the disabled (numbering 100 million) on a leading Hungarian carpooling

36 e AR gene and introduce CAG repeat mutations numbering 100 or more triplets.

37 from four subjects showed additional phyla (numbering 2), genera (numbering 28), and SLOTUs (numberi

38 epeat number) within the two large kindreds, numbering 22 and 23 repeat units.

39 rRNA nucleotides 2618-2620 (Escherichia coli numbering 2583-2585) and 2541(2506), thereby reorienting

40 is positioned by nucleotides A2637 (E. coli numbering, 2602) and (methyl)U2619(2584).

41 owed additional phyla (numbering 2), genera (numbering 28), and SLOTUs (numbering 65).

42 of G protein-coupled receptors, the Tas2rs, numbering 3 to approximately 66, depending on the specie

43 he superscripts denote Ballesteros-Weinstein numbering(3)) is experimentally observed and seems to be

44 rity groups in the European Union: the Roma (numbering 6 million) and the disabled (numbering 100 mil

45 ering 2), genera (numbering 28), and SLOTUs (numbering 65).

46 of saturable binding sites (KD = 1 microM), numbering 8.6 x 10(5) sites/cell.

47 and the number of black USMD GY1 residents, numbering 859, declined from the previous year.

48 We identified 66Y (N1 numbering), a highly conserved amino acid that was criti

49 terotrimer crystal structure, Glu153 (B'beta numbering) abuts the catalytic site on the C subunit, an

50 A single-site mutation of Pro(101) in EPSPS (numbering according to the enzyme from Escherichia coli)

51 ly identical, with the exception of Met-118 (numbering according to the mature BR sequence), which is

52 hose at positions 36 and 75 modulate fusion (numbering according to the Newcastle disease virus [NDV]

53 stal structures have suggested that Lys-110 (numbering according to the Sulfolobus solfataricus enzym

54 141 and Glu275 are in adenylosuccinate lyase numbering), acts as the general base in most fumarase cl

55 46/Val439 sequence differences (BRD4 BD1/BD2 numbering) allowed the identification of compound 27 dem

56 work reaches from betaL328 (Escherichia coli numbering) and betaQ441 via alphaQ399, betaR398, and alp

57 nhibitory phosphorylation at Ser287 (Xenopus numbering) and docking of 14-3-3.

58 r (15)-NH2 (1) (a somatostatin agonist, SRIF numbering) and H-Cpa (2)-c[DCys (3)-Tyr (7)-DTrp (8)-Lys

59 otein surface (D132, Rhodobacter sphaeroides numbering) and leads to another acidic residue near the

60 superscripts refer to Ballesteros-Weinstein numbering) and non-polar interactions with residues in H

61 modified at the DPhe(7) position (alpha-MSH numbering) and pharmacologically characterized for agoni

62 n modified at the Trp(9) position (alpha-MSH numbering) and pharmacologically characterized for agoni

63 n modified at the His(6) position (alpha-MSH numbering) and pharmacologically characterized for agoni

64 ified the electrophilic cysteine as C759 (B1 numbering) and prepared a mixed disulfide between E. col

65 of both the Weinreb amide at C3 (beta-lactam numbering) and the amino acid side chain at C4 are well-

66 in KD1 interacts with Asp-189 (chymotrypsin numbering) and with the carbonyl oxygens of Gly-219 and

67 ct cells started at amino acid 4 (cystatin C numbering), and displayed reversible inhibition of papai

68 Asp 63, Tyr 95, Tyr 188, and His 249 (N-lobe numbering), and to two oxygens from carbonate.

69 an intestine harbors a beneficial microbiota numbering approximately 10(12) organisms per gram of col

70 O-Alu is a representative of an Alu subclass numbering approximately 400,000 copies, suggesting many

71 , Asp114 (TM3), and Asp118 (TM3) (mouse MC4R numbering) are important for melanocortin-based peptide

72 amembrane residues, Lys-28 and Ser-26 (Abeta numbering), as the critical determinants for efficient i

73 )-Lys(9)-Thr(10)-Cys(11)]Thr(12)-NH(2) (SRIF numbering), at the five known human somatostatin recepto

74 cysteine of the channel (Cys-910, rat NaV1.2 numbering; at site 8).

75 erved serine residues, Ser(18) and Ser(20), (numbering based on isoform 1c) form at least one phospho

76 ked a threonine or arginine at position 319 (numbering based on the HXB2 genome) with AOP-RANTES resi

77 assignment of provisional subtypes, subtype numbering beyond "w," and the nomenclature of intergenot

78 drug-resistance (e.g., H275Y NA mutation [N1 numbering]) but revealed mutations outside the NA active

79 Armagh numbering ca. 140 mature trees.

80 itions 163, 288, 289, 444, and 454 (PsAMADHs numbering) can, directly or not, significantly modulate

81 amino acid position 275 (H274Y, universal N2 numbering), conferring resistance against oseltamivir (T

82 esence of a tyrosine at position 249 (PpNRH1 numbering) confers high hydrolase activity for purine ri

83 There is currently no universally accepted numbering convention for the antiviral drug-related resi

84 36, Trp62, Phe64, and Trp72 (kringle residue numbering convention) in ligand binding.

85 ifications, an automated tool for HA subtype numbering conversion, linkouts to disease event data and

86 Note that the numbering corresponds to full-length headpiece.

87 11 and alanine at positions 35 and 39 (hCRF numbering) decreases CRF1R activity and increases CRF2R

88 2, U2506, U2584, and A2602 (Escherichia coli numbering), demonstrating its potential for the analysis

89 utations at A2451, U2585, and C2063 (E. coli numbering) did not significantly affect either of the re

90 f the two conserved Met252 and Met428 (Kabat numbering) disrupted the interface interactions between

91 A new exon 1 has been found that changes the numbering established for the human VDR gene.

92 ues Asp-179(4.60) and Asp-275(6.58) (residue numbering follows the Ballesteros-Weinstein scheme), wit

93 APP that is phosphorylated at Thr668 (pAPP; numbering for APP695), we show that a phosphorylated, ca

94 Thus the sequence alignment and numbering for CH1 domains has been revised to be consist

95 1 in vitro at Ser-692, Ser-695, and Ser-852 (numbering for human isoform).

96 s 491 to 500 (Los Alamos National Laboratory numbering for the HXB2 strain).

97 The E337 and C550 residues (numbering from hChAT) were previously shown to dictate t

98 idly survey a broad collection of compounds, numbering from tens of thousands to millions of members,

99 in this sequence (designated G6 and A7, with numbering from the promoter -10 region).

100 served Asn(633) of the PSI PsaB polypeptide (numbering from the Synechococcus elongatus crystal struc

101 ivation region (viz, A or C at position 1002 numbering from the translation start site of Ik-1) withi

102 residues 238-277 (58-97 in chymotrypsinogen numbering) from the protease domain of factor X bound on

103 single amino acid change at position 226 (H3 numbering), from glutamine (Q226) to leucine (L226), wit

104 t (position 5.38 using Ballesteros-Weinstein numbering) functions as a microswitch for regulating rec

105 Numbering GA733-2 cysteines sequentially from the N term

106 nd slave oscillators, with groups of candles numbering greater than two, creating a synchronised moti

107 ssociated with drug resistance, NA-R292K (N2 numbering), has been found in some H7N9 clinical isolate

108 involving Glu235 (Glu70 in chymotrypsinogen numbering; hereafter, the numbers in brackets refer to t

109 R157K in the gene encoding hemagglutinin (H3 numbering), I109T in the gene encoding nucleoprotein, an

110 catalytic site (R152W, A246T, and D293N, N2 numbering), (ii) subtype-independent substitutions (E119

111 p(105), Val(120), and Leu(158), using OXA-48 numbering) impact on the relative levels of beta-lactone

112 regions (FIV numbering, with equivalent HIV numbering in superscript): I37(32)V in the active core r

113 y in an increasingly high number of channels numbering in the 100s to 1000s.

114 nts in common eiders (Somateria mollissima), numbering in the hundreds to thousands of dead birds, ha

115 Although numbering in the hundreds, only a few RNA modifications

116 he7-d-Trp8-Lys9-Thr10-Phe11], L-363,301 (the numbering in the sequence refers to the position of the

117 ies are abundant in all human serum, usually numbering in the thousands.

118 or down-regulation is Thr(11)Gln(17)Thr(19) (numbering in TM).

119 rotein VP-1 region (positions 1740-1833, Dun numbering) in 49 biopsies obtained from 24 patients with

120 g the side chain of Tyr 71 (Tyr 75 in pepsin numbering) in a novel orientation.

121 for one residue at the 101st position (Kabat numbering) in CDR3 of the variable heavy chain (V(H)), h

122 ue 399 in the B loop of HA2 (residue 72, HA2 numbering) in different monomers of the trimeric A(H1N1)

123 16S rRNA C1054 nucleobase (Escherichia coli numbering) in helix 34, and the carbamoylated gulosamine

124 Arg-15 (bovine pancreatic trypsin inhibitor numbering) in KD1 interacts with Asp-189 (chymotrypsin n

125 stitutions M19V, A232V, D248N, and I436V (N1 numbering) in pH1N1low-1 and pH1N1low-2.

126 Site-directed mutation of Lys-1374 (human numbering) in RBF to Arg or Ile residues almost complete

127 16S rRNA at residues 1540 and 1541 (E. coli numbering) in the anti-Shine-Dalgarno mRNA binding seque

128 ferent residues, including Ser-675 (APP(695) numbering) in the APP cytoplasmic domain has been found

129 Arg(74), Arg(75), and Lys(78) (chymotrypsin numbering) in the catalytic function of activated protei

130 eration of a free radical at Tyr-385 (PGHS-1 numbering) in the cyclooxygenase active site; the Tyr-38

131 ition 292 (using the convention of rhodopsin numbering) in the dolphin LWS cone pigment results in a

132 acing the gatekeeper residue (Thr-338; c-Src numbering) in the inhibitor-binding site with a bulkier

133 on, lysine to glutamine, at position 166 (H3 numbering) in the major antigenic site of HA was reporte

134 ed a cysteine residue at position 442 (EU/OU numbering) in the third constant domain (C(H)3) of the h

135 o acid substitutions at PrP codon 164 (mouse numbering), in the beta2-alpha2 loop region of the prion

136 etion of a single residue, V(H)Ser113 (Kabat numbering), in the elbow region linking the V(H) and C(H

137 ifically at amino-acid residue T668 (APP-695 numbering) increases during staurosporine-induced apopto

138 leucine (L) residue at position HA1-226 (H3 numbering), indicative of human-like receptor binding po

139 acids at position 100 and/or 107 (sequential numbering) into the unmutated Ab 36-65.

140 H257, Y260, H143, Y28, R80, and D91 (residue numbering is from RmL).

141 e polymorphisms at -1082, -819, and -592 bp (numbering is relative to the transcription start site).

142 e c oxidase, Asp407 (Rhodobacter sphaeroides numbering) is at the interface of subunit I and subunit

143 In serine proteases, Gly193 (chymotrypsin numbering) is conserved with rare exception.

144 The data suggest that E89II (E. coli numbering) is critical for the function of the heme copp

145 ) (superscripts denote Ballesteros-Weinstein numbering) is experimentally observed and appears to be

146 (nucleotides 2042 to 2628; Escherichia coli numbering) is implicated in peptidyltransferase activity

147 We found that glycosite "N165" (H3 numbering) is occupied by high-mannose glycans in H3 HA

148 1081 of large subunit rRNA (Escherichia coli numbering) is part of a domain targeted by antibiotics a

149 the conserved Trp256 (murine ferrochelatase numbering) is partially responsible for the observed por

150 erved AKR catalytic tetrad, His(120) (AKR1D1 numbering), is substituted by a glutamate in AKR1D1.

151 A2451 in 23S ribosomal RNA (Escherichia coli numbering) led to the proposal of a mechanism of rRNA ca

152 residues 263-271 (using the DENV serotype 3 numbering) located between the two globular domains of N

153 the single-amino acid R844H exchange (human numbering) located in the 310 helix of the C2A domain of

154 MCADH, while that in LCADH is Glu255 (MCADH numbering), located over 100 residues away in its primar

155 Our calculations show that adding CP-AMPARs numbering <5% of existing synaptic AMPARs is sufficient

156 proteases (residues 143-154 in chymotrypsin numbering) may be responsible for their differential rea

157 Numbering microparticles, including LMPs, might be usefu

158 Numbering more than 600 members, these ligases represent

159 and Trp-107, Mycobacterium tuberculosis KatG numbering) (MYW).

160 additional heteroatom at position 4 (oxazole numbering, N > O > CH) substantially increases activity

161 represent the Ballesteros-Weinstein residue numbering nomenclature(7)) and N86(2.50)D, obtained in c

162 a carboxylic acid, most likely E-242 (bovine numbering), occurred in P(M) and relaxed back in F.

163 (8)-Lys(9)-Thr(10)-Phe(11)-Cys(14)]-OH (SRIF numbering) (ODT-8) by one of the four conformationally b

164 (8)-Lys(9)-Thr(10)-Phe(11)-Cys(14)]-OH (SRIF numbering) (ODT-8) that is potent at all SRIF receptor s

165 the side chain of His -18 (see Figure 1 for numbering of amino acids) of the beta-polypeptide.

166 rvey the entire spine and provide definitive numbering of disks and vertebrae was compared with neuro

167 ine or lysine at position 88 (using sequence numbering of E. coli RNHI), while the handle region popu

168 specially the Arg238-Glu459 salt bridge (the numbering of residues follows myosin II in Dictyostelium

169 ote: In the AOP version of this article, the numbering of the author affiliations was incorrect.

170 IDR, pcaReduce and mpath), as well as to the numbering of the bold-text annotations in the reference

171 sidues, F47, F51, and F58 (denoted using the numbering of the larger headpiece protein).

172 ided with the original annotations and plate numbering of the paper atlas and enable viewing the mate

173 nd Arg134 constitute the catalytic site; the numbering of the residues includes the signal sequence.

174 ality was evaluated by using visual scoring, numbering of visible bronchi, and quantitative measureme

175 amino acids 326-336 (143-154 in chymotrypsin numbering) of factor X (fX) comprise a flexible surface

176 ent study indicated that Tyr99 (chymotrypsin numbering) of factor Xa and Thr99 of activated protein C

177 posed helix 330-338 (162-170 in chymotrypsin numbering) of IXa in its interaction with VIIIa.

178 loops (amino acids 143-154, chymotrypsinogen numbering) of plasma serine proteases play key roles in

179 to-uracil transition at position 70 (E. coli numbering) of RNase P.

180 mutation at position 2058 (Escherichia coli numbering) of the 23S rRNA gene.

181 mediated by the residue at position 374 (HA0 numbering) of the HA2 subdomain as critical for HA trime

182 tions at either position 19, 79 or 81 (Kabat numbering) of the heavy chain strikingly converts h4A11.

183 structured portion (residues 7-29, glucagon numbering) of the micelle-bound 27-residue peptide is 1.

184 acids [aa] 61 to 87 using PB1-F2 amino acid numbering) of the PB1-F2-derived C-terminal peptides fro

185 le mutant (F86L/T93P/S118T; bovine rhodopsin numbering) of the tiger salamander UV cone pigment appea

186 vate the DRN with ON DRN-projecting RGCs out numbering OFF DRN-projecting RGCs.

187 -Phe-Trp(8)-Lys-Thr-Phe-Cys-OH (somatostatin numbering; OLT-8, 9) substituted by imBzl-l- or -d-His a

188 When attacking an Utetheisa egg cluster (numbering on average 20 eggs), the larva subjects it to

189 ve site of 23S rRNA, A2602 (Escherichia coli numbering), on the peptidyl transferase activity of the

190 ential RNA (RPR) and protein subunits (RPPs) numbering one in bacteria, and at least four in archaea

191 -I222T, rg-H274Y, rg-N294S, and rg-R371K, N2 numbering) or zanamivir (rg-E119A and rg-R371K) failed t

192 other Callophycus secondary metabolites, now numbering over 50, are tightly controlled by stereoelect

193 s loop (residues 143-154 in chymotrypsinogen numbering) plays a pivotal role in determining the macro

194 ates that amino acid residue 90 (B. fragilis numbering) plays an important role in conferring substra

195 n of APP, lysine 624, on the basis of APP695 numbering (position 28 relative to Abeta) that plays a c

196 An arginine (R481) (Rhodobacter sphaeroides numbering), positioned between the D-propionates of the

197 ution occurred at C(10) and C(9a) (mitomycin numbering) providing a CD(3) ether and a CD(3) hemiamina

198 4R, C725S, A728S, D730S, and C731S (Na(v)1.4 numbering) reduced block of Na(v)1.4 by 4-, 86-, 12-, 18

199 s3-Xxx7-DTrp8-Lys9-Thr10-Cys14]-Thr-NH2 (the numbering refers to the position in native SRIF), with X

200 y(8)-Lys(9)-Thr(10)-Zzz(11)-Cys(14)]-OH (the numbering refers to the position in native SRIF), with X

201 the flavin-(N3), has been included (residue numbering refers to the yeast sequence).

202 he other extends from positions -73 to -103 (numbering relative to the transcription start site of cf

203 ted at sites 1917 and 1951 (Escherichia coli numbering), respectively, in the 23S rRNA gene of C. bur

204 rt, and integrase), in which the amino acid numbering restarts at the first codon position of each d

205 yrosyl radical on R2 (Y122, Escherichia coli numbering) reversibly generates the transient thiyl radi

206 (The numbering scheme for gp41 (e.g., gp41(553-590) for 1) ad

207 utein sequence begins with Gly121 (using the numbering scheme for the wild-type protein) and terminat

208 The IgStrand numbering scheme lays the foundation for the systematic

209 a conserved cysteine residue at position 83 (numbering scheme of the 140-residue form of FGF-1).

210 The numbering scheme powers an algorithm implemented in the

211 The "IgStrand numbering scheme" enables the identification of Ig struc

212 2 (TM7) equivalent to Lys(7.45) (Ballesteros numbering scheme) involved in covalently attaching retin

213 Multiple different numbering schemes exist, they vary in the nomenclature t

214 The chromosome numbering schemes of the genetic linkage and physical ma

215 nnotate sequences with the five most popular numbering schemes: Kabat, Chothia, Enhanced Chothia, IMG

216 ressed by phosphorylation at Ser287 (Xenopus numbering; Ser216 of human Cdc25C) and subsequent bindin

217 Numbering sFRP-1 cysteines sequentially from the N termi

218 saturated acyl chains at the stereospecific numbering (sn)-1 position from PC and likely a channelin

219 st that plant CPS prefers the stereospecific numbering (sn)-1 position whereas E. coli CPS acts on sn

220 nogonids (sea spiders) are marine arthropods numbering some 1,160 extant species.

221 d to Cys-305 (Cys-331 in human type II IMPDH numbering), suggesting that Cys-305 functions as a nucle

222 We establish a class D1 generic residue numbering system (CD1) to enable comparisons with orthol

223 achieved by the use of a computer encrypted numbering system at the National Cancer Institute) and b

224 A standardized numbering system for HBV polymerase is proposed.

225 ed on this information, we propose a uniform numbering system for the beta3 exons.

226 A revised numbering system has been adopted for cowpea chromosomes

227 (residue -34 to -15 and -11 to +6, using the numbering system in which the conserved histidine residu

228 The new consensus rt domain numbering system is genotype independent and allows inve

229 Finally, a rule-base module based on a teeth numbering system is proposed to match labels of detected

230 In BPR, Glu142 (the GPR numbering system is used) is deprotonated and can act as

231 otrypsin numbering system; for the urokinase numbering system it is Ile(159)-Lys(404)) and two point

232 at involves, principally, Lys345 and Glu211 (numbering system of enolase 1 from yeast).

233 s to HVS and KSHV ORFs and used the HVS/KSHV numbering system to designate these ORFs.

234 at position +4 in the beta-polypeptide (the numbering system used assigns position 0 to the His whic

235 in lacking the N-terminal pyroglutamate (the numbering system used has Asp2 as the N-terminal residue

236 ds to Gly(193) in chymotrypsin, which is the numbering system used subsequently.

237 m label was located at positions (patchoulol numbering system) C5 (both isotopomers, ca. 100%) and C1

238 rg59+Asn108 mutants (using the P. falciparum numbering system) exhibit no significant fitness defects

239 H310A, H435Q, H435R, and H310A/H435Q, Kabat numbering system) expressed well in mammalian cell cultu

240 Residue 192 (chymotrypsin numbering system) in thrombin, activated protein C, and

241 group of His157 (His159 in the yeast enolase numbering system) is in van der Waals contact (4.5 A) wi

242 acidic residue at position 144 (chymotrypsin numbering system) is the primary determinant of the dist

243 Lysine 72 (using the vertebrate numbering system) is trimethylated in cytochromes c from

244 ations for the 3-residue region 237-240 (ABL numbering system) of TEM-1 beta-lactamase.

245 riants (I253A, H310A, and H310A/H435Q; Kabat numbering system) that exhibited differential serum pers

246 Lys65, His66, and Tyr71 (using the thrombin numbering system), that were resistant to HCII inhibitio

247 due that occupies position 192 (chymotrypsin numbering system), which plays a pivotal role in determi

248 man, were aligned, using the now-known Kabat numbering system, and a quantitative measure, variabilit

249 equences were also aligned using a different numbering system, since the locations of their CDRs (31-

250 framework to replace the inconsistent clade numbering system, using informal taxonomic names: Glugei

251 eported at positions according to the E.coli numbering system.

252 d proteins for variant reporting and an exon numbering system.

253 sidues Ile(16)-Lys(243) (in the chymotrypsin numbering system; for the urokinase numbering system it

254 in the region and legacy exon and amino acid numbering systems.

255 mmon biological agents in the sea, typically numbering ten billion per litre.

256 erases of the exocyclic N6 of A2058 (E. coli numbering) that forms the macrolide binding site in the

257 e insertion loop at residue 60 (chymotrypsin numbering) that has been implicated in modeling studies

258 (NA)-like protein (NA-F144C and NA-T342A, N2 numbering) that increased the virus titers in three mamm

259 rm of the Abl tyrosine kinase (H396P; Abl-1a numbering) that is resistant to the Abl inhibitor imatin

260 fide bond (Cys(191)-Cys(220) in chymotrypsin numbering) that links two beta-loop structures that defi

261 g-73, Arg-75, and Arg-77 in chymotrypsinogen numbering) that play key roles in the function of thromb

262 erved tyrosine 837 (Saccharomyces cerevisiae numbering), that contacts the catalytic histidine of eIF

263 ines, R481 and R482 (Rhodobacter sphaeroides numbering), that interact directly with heme a and the h

264 D132(I) (subunit I; Rhodobacter sphaeroides numbering), the entrance of the K-channel has not been c

265 exchange or R915E, R916E substitutions (fly numbering) to effect local charge reversal at the 310 he

266 1) at Thr(697) and/or Thr(855) (rat sequence numbering) to inhibit phosphatase activity and increase

267 dine residue (His-287, murine ferrochelatase numbering) to leucine and reduced over 2 orders of magni

268 and that the NPXY tyrosine (Tyr743 by APP751 numbering, Tyr682 in APP695) is required for APP endocyt

269 hour) could be obtained via parallelization (numbering up) by simply wrapping several membrane tubing

270 ing of the base at position 1492 (by E. coli numbering) upon binding to the E. coli rRNA A site, but

271 both residues 145-157 and 201-212 (human p53 numbering used throughout).

272 ted that aspartate 143 (Escherichia coli TGT numbering) was involved in heterocyclic substrate recogn

273 eophilicity at the delta10 double bond (GGPP numbering) was synthesized and incubated with taxadiene

274 nizes MYPT1 phosphorylated at Thr(654) (M130 numbering), we determined that this calcium-independent

275 Automated disk-vertebra detection and numbering were concordant with neuroradiologist assignme

276 esidues (Tyr(677) and Tyr(701), using hFGFR1 numbering) were essential for bioactivity, but the remai

277 ovel NA-K432E and NA-T438I substitutions (N2 numbering) were identified at elevated frequencies (104/

278 Arg73, Arg75, and Arg77 in chymotrypsinogen numbering) were individually substituted with a Glu.

279 F linkage sites (using the original sequence numbering) were residue 39, which is at the beginning of

280 s(230), Arg(233), and Lys(239) (chymotrypsin numbering) were substituted with Ala in separate constru

281 teine at positions 3 and/or 14 (somatostatin numbering) were/was substituted with d-cysteine, norcyst

282 e chains of two residues, S353 and T354 (NIS numbering), were identified as the Na(+) ligands at Na2.

283 , Phe112Tyr, and Ala115Val (AgRP full-length numbering), were incorporated into the peptide macrocycl

284 tion, two substitutions, H274Y and R292K (N2 numbering), were introduced into each NA gene for compar

285 , or dual sulfation at both positions (Kabat numbering where H designates heavy chain) leads to an in

286 s Ser236 (Dictyostelium discoideum myosin II numbering) which was proposed to be involved in a hydrog

287 s (Gly22, His151, Lys243, and Glu321, atDGD2 numbering) which were entirely conserved between the str

288 ucleotide at position 1408 (Escherichia coli numbering), which is an adenosine in prokaryotic ribosom

289 This preference is linked to Phe902 (human numbering), which is responsible for low-affinity bindin

290 d, with the single exception of Glu-22 (IL-3 numbering), which is strictly conserved but nonetheless

291 ntains an aspartate residue [Asp157 (spinach numbering)], which is highly conserved in eukaryotic and

292 on, VRVIII (amino acids 586 to 591 [AAV8 VP1 numbering]), which lies on the surface of the protrusion

293 ernational ImMunoGeneTics information system numbering), whose presence rescued domain folding and st

294 Arg-173, Lys-175, and Lys-179; chymotrypsin numbering) with Ala, using an expression system that all

295 0d, K60f, E217, and R221 in chymotrypsinogen numbering) with alanine altered the substrate specificit

296 ite Ser-581 (full-length fatty acid synthase numbering) with alanine completely eliminated catalytic

297 His42, His124, and Glu126 (Aquifex aeolicus numbering), with particular attention paid to the effect

298 combinations of three critical regions (FIV numbering, with equivalent HIV numbering in superscript)

299 itions 1345-1350/1372-1376 (Escherichia coli numbering), within the three-way junction loop, which bi

300 rporation of a quaternary center at C-6 (THP numbering) would restore the facial selectivity with mor