ライフサイエンスコーパス: nurse cell

1 rs the endocycle and develops as a polyploid nurse cell.

2 um, and the cell exits meiosis and becomes a nurse cell.

3 n whether to differentiate as an oocyte or a nurse cell.

4 cause the presumptive oocyte to develop as a nurse cell.

5 ases during its maturation into a functional nurse cell.

6 the remaining fifteen cells become polyploid nurse cells.

7 pod classes, gametogenesis functions without nurse cells.

8 enter the endocycle and develop as polyploid nurse cells.

9 in the squamous stretch cells overlying the nurse cells.

10 e polyploid in preparation for their role as nurse cells.

11 e structures and the formation of binucleate nurse cells.

12 to the oocyte depends upon apoptosis of the nurse cells.

13 d the structural integrity of the oocyte and nurse cells.

14 ll cluster to resist compressive forces from nurse cells.

15 in the formation of egg chambers with extra nurse cells.

16 n the regulation of actin-bundle assembly in nurse cells.

17 the endoreplication defects in Elg1-depleted nurse cells.

18 is region are not necessary for apoptosis in nurse cells.

19 nterconnect the oocyte and its 15 associated nurse cells.

20 n the majority of cytoplasm is lost from the nurse cells.

21 by taking up materials transported from the nurse cells.

22 be inappropriately present in morula mutant nurse cells.

23 oid cell cycles to prepare for their role as nurse cells.

24 es the amount of satellite DNA propagated in nurse cells.

25 hile the remaining 15 cells differentiate as nurse cells.

26 ay participate in membrane biogenesis in the nurse cells.

27 ation often resulting in the formation of 16 nurse cells.

28 pool resources of oocyte-associated germline nurse cells.

29 the oocyte and exhibit variation within the nurse cells.

30 queeze into tiny spaces between cells called nurse cells.

31 ntents from the interconnected sister cells, nurse cells.

32 regulator of postmitotic growth in germline nurse cells.

33 ted in response to increased constriction by nurse cells.

34 chanical pressure imposed by the surrounding nurse cells.

35 study F-actin dynamics within the Drosophila nurse cells.

36 into six meiotic substages, as well as dying/nurse cells.

37 tain the meiotic cycle and develop as pseudo-nurse cells.

38 thway, and the remaining 15 differentiate as nurse cells.

39 ors Bicaudal D (BicD) and Egalitarian in the nurse cells.

40 operly or undergo DNA fragmentation in dying nurse cells.

41 tene cells appear to function transiently as nurse cells.

42 retch follicle cells to cannibalize adjacent nurse cells-a process necessary to remodel egg chambers

43 en the oocyte is removed from the egg field, nurse cells abort their differentiation program, undergo

44 ex accumulated in large processing bodies in nurse cells, accompanied by MT reorganization.

45 arly formed in Nasonia, except that anterior nurse cells accumulate significantly more nuage, in asso

46 ocalizes mRNAs and proteins deposited by the nurse cells across the oocyte.

47 ing, Enabled localizes to barbed ends of the nurse cell actin filaments, suggesting its mechanism of

48 In vivo, the assembly of nurse-cell actin bundles is accompanied by extensive per

49 Both nurse cell and oocyte chromosomes require cup to attain

50 lop to form a germline cyst consisting of 15 nurse cells and an oocyte.

51 hile nanos RNA is synthesized by the ovarian nurse cells and appears at the posterior pole of the ooc

52 s functional and localizes to nuclei of both nurse cells and follicle cells during oogenesis.

53 that both EcR-A and EcR-B1 are expressed in nurse cells and follicle cells throughout oogenesis.

54 al dynein actively moves microtubules within nurse cells and from nurse cells to the oocyte via the c

55 an exaggerated inflammatory response around nurse cells and in the pleural cavity.

56 ly assembles actin filaments into bundles in nurse cells and maintains their stability under fluctuat

57 ransport through the ring canals linking the nurse cells and oocyte appears to be independent of both

58 Gnu is normally expressed in the nurse cells and oocyte of the ovary and is degraded duri

59 i may regulate chromosome compaction in both nurse cells and oocyte.

60 n cystocytes for maturation into specialized nurse cells and oocyte.

61 eurons, the cardia (proventriculus), and the nurse cells and oocytes of the ovary.

62 nd mitotic clonal analysis reveals that both nurse cells and oocytes require SMN to maintain normal o

63 As GSC daughters differentiate into nurse cells and oocytes, nurse cells, like embryonic som

64 erate cystoblast daughters that develop into nurse cells and oocytes.

65 e reactivated, and DNA damage accumulates in nurse cells and oocytes.

66 n smn cause abnormal nuclear organization in nurse cells and oocytes.

67 protein is made but excluded from nuclei of nurse cells and oocytes; upon egg activation, YA acquire

68 he oocyte then comes to lie posterior to the nurse cells and signals through the Gurken/Egfr pathway

69 egg chambers that are supported by germline nurse cells and surrounded by somatic follicle cells.

70 lex involved in localizing mRNAs both within nurse cells and the developing oocyte.

71 transport of cytoplasmic components between nurse cells and the oocyte during previtellogenic stages

72 d traffic centrosomes and organelles between nurse cells and the oocyte to form the Balbiani body, a

73 unctate distribution in the cytoplasm of the nurse cells and the oocyte until the protein disappears

74 e defective in osk mRNA localization in both nurse cells and the oocyte.

75 that yl RNA is synthesized by the germ line nurse cells and then transported to the oocyte.

76 chanism of movement of gurken RNA within the nurse cells and towards and through ring canals connecti

77 Drosophila bicoid mRNA is synthesized in the nurse cells and transported to the oocyte where microtub

78 ale hawaiensis, a species whose ovaries lack nurse cells and whose eggs lack obvious polarity.

79 s in the cytoplasm and perinuclear region of nurse cells and, like Otu, moves to the periphery of the

80 ells have endoreplicated DNA (as observed in nurse cells), and (4) oocyte-specific cytoplasmic marker

81 in CifA in oogenesis localizes to stem cell, nurse cell, and oocyte nuclei, as well as embryonic DNA

82 ithelium, detach from it, invade neighboring nurse cells, and migrate as a coherent cluster.

83 volving acidification, similar to Drosophila nurse cells, and only infrequently by apoptosis.

84 f its cell types-the somatic epithelial, the nurse cells, and the oocyte.

85 n of the actin cytoskeleton and a failure of nurse cell apoptosis, each of which are required for nor

86 oth of these phenomena are manifestations of nurse-cell apoptosis.

87 We have determined that nurse cells are cleared from the Drosophila egg chamber

88 hambers, where the oocyte and 15 surrounding nurse cells are connected in a stereotypic network via i

89 rmeabilization, and DNA fragmentation of the nurse cells are impaired when phagocytosis is inhibited.

90 itude and prolonged nature of this response, nurse cells are rarely destroyed by infiltrating cells.

91 mic bridges, and determinants synthesized in nurse cells are transported through these bridges to the

92 ng oogenesis, Hsp70 inducibility was lost in nurse cells around stage 10, in a posterior-to-anterior

93 ted by intercellular bridges that develop as nurse cells as well as an oocyte.

94 e cells: the centripetally migrating and the nurse cell-associated follicle cells.

95 DNA fragmentation begins in nurse cells at stage 12, following the completion of cyt

96 endently regulating chromosome compaction in nurse cells at the end of the unique endoreplication cyc

97 During oogenesis in wild-type Drosophila, nurse cells become polyploid and do not contain cyclin B

98 is disrupted, membranes separating adjacent nurse cells break down and the structural integrity of t

99 es in the follicular epithelium that uncover nurse cells but not the oocyte.

100 These mRNAs originate in the nurse cells, but how they move into the oocyte remains p

101 proteins are expressed in both follicle and nurse cells, but they do not accumulate at detectable le

102 In Drosophila, each oocyte is connected to nurse cells by cytoplasmic bridges, and determinants syn

103 nein-mediated processes such as migration of nurse cell centrosomes into the oocyte during the early

104 chromosomes, neither protein is required for nurse cell chromosome development or oocyte production.

105 d plays a role both in mRNA localization and nurse cell chromosome organization, probably by regulati

106 Thus, loss-of-function mutations arrest nurse cell chromosome reorganization at the five-blob st

107 uired in germ-line cells for cyst formation, nurse cell chromosome structure and egg maturation.

108 ough loss of Su(Hw) causes global defects in nurse cell chromosome structure, we demonstrate that the

109 ell cycle, by studying changes in Drosophila nurse cell chromosomes throughout the 10 to 12 endocycle

110 CP190 extensively co-localize with Su(Hw) on nurse cell chromosomes, neither protein is required for

111 share another phenotype, persistent polytene nurse cell chromosomes.

112 Prior to initiating transfer, nurse cells co-cluster by scRNA-seq with their pro-oocyt

113 e show in live egg chambers that, within the nurse cell compartment, dynein actively transports green

114 by guided migration and invasion through the nurse cell complex toward the oocyte.

115 cell sheet involution between the oocyte and nurse cell complex which patterns the operculum structur

116 ion of the structural organization of oocyte-nurse cell complexes to generate multinucleate germline-

117 During Drosophila oogenesis, 15 nurse cells connected by ring canals to each other and t

118 tethering of nurse cell nuclei, "dumping" of nurse cell contents into the oocyte, establishment of oo

119 egeneration and a failure of the transfer of nurse cell contents to the oocyte, indicating that TGF-b

120 We provide evidence that in nurse cells, continuous filopodia-like actin cables, gro

121 positioning is crucial during dumping, when nurse cells contract and expel their contents into the o

122 When nurse cells contract, actin cables associate laterally w

123 No previously known mechanism explains how nurse cells coordinate growth collectively.

124 r to dumping, actin cables initiate from the nurse cell cortex and elongate toward their nuclei, push

125 led important roles in oocyte determination, nurse cell cortical integrity and nurse cell dumping, an

126 thin the oocyte, and proper execution of the nurse cell cycle (endoreplication of DNA) and the oocyte

127 erantia-bicoid mRNA complex formation in the nurse cell cytoplasm allows anterior-specific transport

128 r the formation of parallel actin bundles in nurse cell cytoplasm and bristle shaft cells.

129 reaming begins during stage 10B, just before nurse cell cytoplasm is dumped into the oocyte.

130 vities were necessary for normal transfer of nurse cell cytoplasm to the oocyte.

131 utation of dDP in the germline also prevents nurse cell cytoplasm transfer to the oocyte, resulting i

132 f follicle cell migration, and completion of nurse cell cytoplasm transport (dumping).

133 es and are sterile due to a severe defect in nurse cell cytoplasm transport caused by the absence of

134 kinked bristles and are fertile with a mild nurse cell cytoplasm transport defect.

135 Subsequently, to mix incoming nurse cell cytoplasm with ooplasm, a subcortical layer o

136 Nonetheless, bicoid mRNA injected into the nurse cell cytoplasm, withdrawn, and injected into a sec

137 tions indicate a rise in free calcium in the nurse-cell cytoplasm coincident with the permeabilizatio

138 g currents and thorough mixing of oocyte and nurse-cell cytoplasm.

139 n tumor is required for the formation of the nurse cell cytoplasmic actin array that is essential for

140 cytoplasm transport caused by the absence of nurse cell cytoplasmic actin bundles.

141 Prior to fertilization, the nurse cells' cytoplasmic contents are transported into t

142 g nurse cells may prevent destruction of the nurse cell cytoskeleton and the connected oocyte.

143 of a small subset of follicle cells prevents nurse cell death and cytoplasmic dumping.

144 ant, in which egg chambers undergo premature nurse cell death and degeneration.

145 and show dumpless egg chambers and premature nurse cell death in germline clones.

146 dcp-1 mutants are viable and nurse cell death in late oogenesis occurs normally.

147 ne, pita, leading to lethality and defective nurse cell death in late oogenesis.

148 ive Drice formed localized aggregates during nurse cell death in late oogenesis; however, active Dric

149 Early nurse cell death is not observed in the dcp-1/pita doubl

150 tage 13, indicating a block in developmental nurse cell death.

151 on the border cells and their substrate, the nurse cells; decreased border cell Myosin dynamics; and

152 Nurse cells die by a programmed cell death (PCD) pathway

153 As oogenesis proceeds, 15 nurse cells die for every oocyte that is produced.

154 However, in the presence of the oocyte, nurse cells differentiate and enter an unusual apoptosis

155 Progression through the nurse cell differentiation program requires the presence

156 ail to complete cytoplasm transport from the nurse cells, DNA fragmentation is markedly delayed and b

157 go multiple rounds of endoreplication as the nurse cells do in a normal egg chamber.

158 increased Puc activity result in incomplete nurse cell dumping and aberrant dorsal appendages.

159 Mouse oocyte development and nurse cell dumping are supported by dynamic, cell-specif

160 nsfer into the oocyte, events reminiscent of nurse cell dumping in Drosophila We propose that cytopla

161 ssion in the follicle cells and a failure of nurse cell dumping to coordinate with dorsal appendage e

162 ilaments in late nurse cells that facilitate nurse cell dumping, and migration of somatic border cell

163 rmination, nurse cell cortical integrity and nurse cell dumping, and support the idea that Capping pr

164 ablished Drosophila oogenesis, in particular nurse cell dumping, as a new model to determine how PGs

165 During nurse cell dumping, Enabled localizes to barbed ends of

166 anos localization initiates immediately upon nurse cell dumping, whereby diffusion, enhanced by micro

167 rd mitochondrial transport until the time of nurse cell dumping.

168 ia intracellular bridges by a process called nurse cell dumping.

169 red to coordinate centripetal migration with nurse cell dumping.

170 events occurring within the germline-derived nurse cells during Drosophila mid-oogenesis or follicle

171 r the death and removal of germ-line-derived nurse cells during late oogenesis.

172 transcripts, which are initially detected in nurse cells during mid-oogenesis, become localized to th

173 r cytoplasmic actin filament assembly in the nurse cells during oogenesis, although it may facilitate

174 cin is in the nuclei of the germline-derived nurse cells during stages 10B-12 (S10B-12) and at the nu

175 actin breakdown resulting in multi-nucleate nurse cells, early F-actin filament and aggregate format

176 for how actin structures position nuclei in nurse cells, employing evolutionary conserved machinery.

177 cle switching, migration, symmetry breaking, nurse-cell engulfment, egg-shell formation, and corpus l

178 cells) during their brief phagocytic role in nurse-cell engulfment.

179 sophila, where a small number of specialized nurse cells expel their contents into the enlarging oocy

180 ally decreases as they adopt the alternative nurse cell fate.

181 ther than forming oocytes, consistent with a nurse cell fate.

182 ubcortical actin breakdown and disruption of nurse cell-follicle cell contacts, followed by germ cell

183 s an important role in cortical integrity of nurse cells, formation of robust bundled actin filaments

184 The syncytium is a nurse cell formed within the roots of Glycine max by the

185 ed from DBA erythroid cells might impede the nurse cell function of central macrophages of erythrobla

186 etween border cells and their substrate, the nurse cells, functions in a positive feedback loop with

187 the oocyte-synthesized Dacapo protein to the nurse cells generates a network of coupled oscillators t

188 show that knockdown of Hop in the germ line nurse cells (GLKD) of Drosophila ovaries leads to activa

189 y other polyploid and polytene cells, during nurse cell growth the major satellite DNAs become highly

190 Unexpectedly, nurse cells in Akap200 mutant ovaries also had enlarged,

191 1 (EMS1) in forming the monolayer of tapetal nurse cells in Arabidopsis.

192 lution of sedentary endoparasitism and plant nurse cells in cyst and root-knot nematodes.

193 ox genes are expressed in Sertoli cells, the nurse cells in direct contact with developing male germ

194 Nurse cells in female-sterile alleles of morula begin to

195 ramming in germline companion cells, such as nurse cells in insects and vegetative nuclei in plants,

196 The death of nurse cells in late oogenesis is developmentally regulat

197 is stress-induced, whereas the cell death of nurse cells in late oogenesis is developmentally regulat

198 ive migration of the border cells in-between nurse cells in the Drosophila egg chamber.

199 ic mice reduces that protein specifically in nurse cells in the testis.

200 s cause a metaphase arrest, and endo cycling nurse cells inappropriately reenter mitosis in mr mutant

201 During stage 13, nurse cells increasingly contain highly fragmented DNA a

202 sues, produces a very different phenotype in nurse cells, inducing formation of highly enlarged lipid

203 esis its RNA is rapidly transported from the nurse cells into the oocyte where it accumulates specifi

204 ted with apoptosis and that apoptosis of the nurse cells is a necessary event for oocyte development.

205 responses occur at the site of infection, a nurse cell known as the syncytium.

206 Ichinohe occurs at the site of infection, a nurse cell known as the syncytium.

207 ppear in the germarium, suggesting that some nurse cells lack affinity for invading prefollicular cel

208 In mutant but not wild-type endomitotic nurse cells, "late S" patterns of bromodeoxyuridine inco

209 differentiate into nurse cells and oocytes, nurse cells, like embryonic somatic cells, silence genes

210 was highly expressed in SCID thymus and in a nurse cell line, but not in other thymic epithelial cell

211 t the cytoskeletal and nuclear events in the nurse cells make use of the machinery normally associate

212 This limited caspase activation in dying nurse cells may prevent destruction of the nurse cell cy

213 es show defects in actin filament formation, nurse cell membrane stability and border cell migration.

214 marium, but it is predominantly localized to nurse cell membranes.

215 LDs originate in nurse cells (NCs) and are transported to the oocyte.

216 BCs move between a group of cells, the nurse cells (NCs), that are enclosed by a monolayer of f

217 tes develop together with 15 sister germline nurse cells (NCs), which pass products to the oocyte thr

218 Loss-of-function mutations block nurse cell nuclear transitions at the five-blob stage an

219 accompanied by extensive perforation of the nurse-cell nuclear envelopes, and both of these phenomen

220 In Drosophila nurse cells, nuclear positioning is crucial during dumpi

221 the germline causes F-actin formation in the nurse cell nuclei and germinal vesicle during mid-oogene

222 ng oocyte maturation, is required for timely nurse cell nuclei clearing from mature egg chambers.

223 eggshell and embryonic patterning and arrest nurse cell nuclei during a stage-specific reorganization

224 icle cells and is essential for clearing the nurse cell nuclei in late oogenesis.

225 show a high percentage of egg chambers with nurse cell nuclei persisting past stage 13, indicating a

226 56 is required for bulk mRNA export from the nurse cell nuclei that supply most of the material to th

227 e oocyte cortex, actin-mediated tethering of nurse cell nuclei, "dumping" of nurse cell contents into

228 teins do bind to the polytene chromosomes in nurse-cell nuclei and enter the oocyte nucleus.

229 embryos, third instar larvae, and late stage nurse cells of adult females.

230 laments and aggregates, within the posterior nurse cells of S9 follicles; wild-type follicles exhibit

231 colocalizes with Exu in both the oocyte and nurse cells of the Drosophila egg chamber.

232 Here, we use the nutrient-storing nurse cells of the fly ovary to study the cellular effec

233 with this, dp53 RNA levels were high in the nurse cells of the ovary.

234 anterior pole of the egg chamber towards the nurse cell-oocyte boundary.

235 t the time follicle cells first surround the nurse cell-oocyte complex.

236 duce ovarian follicles with multiple sets of nurse cell-oocyte complexes.

237 he follicular epithelium that surrounds each nurse cell/oocyte cluster to form an egg chamber.

238 amples of intercellular RNA trafficking from nurse cells or somatic tissues to developing gametes.

239 The genes promoting oocyte development and nurse cell PCD are upregulated, whereas the genes that r

240 PRC2-dependent silencing globally, while in nurse cells Pcl declines and newly induced Scm concentra

241 ins to condense during late S phase and that nurse cell polytene chromosome structure is controlled b

242 The cytogenetic locations on the nurse cell polytene chromosomes have been determined for

243 ytogenetic map of An. funestus using ovarian nurse cell polytene chromosomes.

244 Sertoli cells, also known as 'mother' or 'nurse' cells, provide nutrients, paracrine factors, cyto

245 At a late stage in Drosophila oogenesis, nurse cells rapidly expel their cytoplasm into the oocyt

246 Nurse cells require microtubules and Exuperantia to supp

247 ctional communication between the oocyte and nurse cells, revealing the oocyte as a critical regulato

248 lized at the asymmetric actin baskets on the nurse cell side of the ring canals.

249 trong allele of cappuccino has multinucleate nurse cells, similar to those previously described in ch

250 d border cell Myosin dynamics; and increased nurse cell stiffness as measured by atomic force microsc

251 osin activity in the border cells to control nurse cell stiffness to promote migration.

252 ression of constitutively active RhoL led to nurse cell subcortical actin breakdown and disruption of

253 Mice depleted of WT1 in Sertoli nurse cells suffered from increased germ cell apoptosis,

254 sues supporting early development and single nurse cells supporting gametogenesis.

255 ogenesis, RCs connect the maturing oocyte to nurse cells supporting its growth.

256 terminally differentiated pollen vegetative nurse cell surrounding the sperm cells undergoes a progr

257 es as it attempts to develop a multinucleate nurse cell (syncytium) serving to nourish the nematode o

258 Following delivery of nurse cell-synthesized oskar mRNA into the oocyte by dyn

259 on of robust bundled actin filaments in late nurse cells that facilitate nurse cell dumping, and migr

260 e this unusual apoptosis program in immature nurse cells that have not completed differentiation.

261 ggest the presence of cytoplasmic factors in nurse cells that inhibit the initiation of DNA fragmenta

262 tiates into an oocyte, while the rest become nurse cells that supply the oocyte with mRNAs, proteins,

263 ge, develop into six oocytes supported by 24 nurse cells that transfer cytoplasm and organelles to ge

264 ocalization is limited to chromosomes within nurse cells, the specialized cells that support oocyte g

265 suggest PGs act in both the border cells and nurse cells, the substrate on which the border cells mig

266 in transfer of cytoplasm from the accessory nurse cells through the ring canals into the oocyte.

267 erials from the interconnected sister cells (nurse cells) through ring canals, the cytoplasmic bridge

268 hoL transgene in the Drosophila ovary caused nurse cells to collapse and fuse together.

269 border cells to promote migration and in the nurse cells to maintain cluster cohesion.

270 s eliminates excess germ cells that acted as nurse cells to provide cytoplasmic components to maturin

271 illators that controls the cell cycle of the nurse cells to regulate cyst growth.

272 th the incomplete transfer of cytoplasm from nurse cells to the developing oocyte.

273 c movements, translocates nanos RNA from the nurse cells to the ooctye posterior.

274 In addition, final cytoplasm transport from nurse cells to the oocyte depends upon apoptosis of the

275 ves microtubules within nurse cells and from nurse cells to the oocyte via the cytoplasmic bridges, t

276 completion of fast cytoplasm transport from nurse cells to the oocyte, an event critical for the pro

277 he completion of cytoplasm transfer from the nurse cells to the oocyte.

278 nals that allow cytoplasm transport from the nurse cells to the oocyte.

279 p (Shot) controls the direction of flow from nurse cells to the oocyte.

280 is to transport cytoplasmic materials from 'nurse' cells to oocytes, a critical process for developi

281 ation within the early oocyte, distinct from nurse-cell-to-oocyte RNA transport.

282 the effect of viscous drag from surrounding nurse cells together with confinement of all of the cell

283 During Drosophila oogenesis, nurse cells transfer their cytoplasmic contents to devel

284 his species primarily result from programmed nurse cell turnover after transfer rather than defective

285 We find that nurse cells undergo three distinct types of endocycle wh

286 dcp-1- nurse cells were defective in the cytoskeletal reorganiz

287 ts of epidermal cells, mesoderm, trachea and nurse cells were identified, but the majority of the str

288 oping females and their associated syncytial nurse cells were significantly smaller than in control p

289 gration of oskar mRNA in real time, from the nurse cells where it is produced to the posterior cortex

290 kinesin I activity elevates RNP motility in nurse cells, whereas disruption of dynein activity inhib

291 hila ovaries, perinuclear nuage forms in the nurse cells, while compositionally similar polar granule

292 three forms of particle movement within the nurse cells, while transport through the ring canals lin

293 In oocyte-contacting nurse cells with asymmetric cable arrays, nuclei move aw

294 owing the intracellular bridges that connect nurse cells with each o ther and to the developing oocyt

295 ession of Fascin increases, the frequency of nurse cells with high levels of nuclear actin, but neith

296 zygotes exhibit a reduction in the number of nurse cells with high nuclear actin levels.

297 could sense elevated cytoplasmic calcium; in nurse cells with reduced levels of Quail protein, villin

298 dhesions of developing germ cells to Sertoli nurse cells, with likely secondary degeneration of Serto

299 versing a network of large germ line-derived nurse cells within the ovary.

300 that many mutant egg chambers contain only 8 nurse cells without an oocyte which is phenocopied in di