ライフサイエンスコーパス: o-

1 o-(Pyrrolidinylmethyl)phenylboronic acid (4) and its com

2 o-(Trifluoromethyl)phenyl substituent contributes to ste

3 o can be determined to a precision of +/-0.2%o (+2sigma) using 1-10 microg of Mo.

4 )(CO)(10) (2-X, where X = o-, m- or p-NH(2); o-, m- or p- OH; p-H, -Br, -NO(2), -COOH or -CH(2)COOH)

5 activated complex, referred to as [4](2+) [((o-(Ph(2) P)C(6) H(4) )(2) (o-Ph(2) PO)C(6) H(4) )SbAuNTf

6 re length (1.9-2.2 mum) and external [Ca(2+)]o (1-2.5 mM), which produce an increase of TP, do not af

7 l/mg protein), and inhibited by guanosine-5'-o-(3-thiotriphosphate) (GTPgammaS) suggesting that these

8 oxidized with hydrogen peroxide to afford [((o-(Ph(2) P)C(6) H(4) )(2) (o-Ph(2) PO)C(6) H(4) )SbAuCl(

9 pyranopyridines can be prepared by allowing o-(1-alkynyl)arenecarboxaldehydes and ketones to react w

10 Heck cyclization of butenalide 22 having an o-(N-acetyl-N-benzylamino)phenyl substituent at C2 provi

11 nactive, as were aromatic species lacking an o- or m-nitrogen atom in the ring, or possessing multipl

12 to the more tractable trifluoride analogue ((o-(Ph2P)C6H4)2SbF3)AuCl (3-Cl) by treatment with a fluor

13 eadily available hydrazones of aldehydes and o-(trimethylsilyl)aryl triflates.

14 including pyrazolyl-substituted anilines and o-, m-, and p-phenylenediamine as pi-conjugated spacers.

15 s, namely [p-(Mes2B)C6H4(NMe3)]+ ([1]+) and [o-(Mes2B)C6H4(NMe3)]+ ([2]+).

16 ) H(4) )(2) Ge(IV) Cl(2) ]Pt(II) Cl(2) and [(o-(Ph(2) P)C(6) H(4) )(2) ClGe(III) ]Pt(III) Cl(3) , two

17 [((o-(Ph2P)C6H4)2SbCl)Au](+) ([1](+)) and [((o-(Ph2P)C6H4)2SbF3)Au](+) ([3](+)), which have been isol

18 At the average twist angle o ~ 1.56 , a theoretically predicted "magic angle" for t

19 eveal the rich physics at small twist angles o < 4( ), and identify a particular magic angle at which

20 -1H-indenes (from beta-alkyl-beta-alkyl/aryl-o-(alkynyl)styrenes) and 3-iodobenzofulvenes (from beta,

21 The alkene-based o-[1-(p-MeO-phenyl)vinyl]benzoates (PMPVB) donors that c

22 orescence, thiazole orange (TO)-PNA and [bis-o-(aminoethoxy)phenyl]pyrrolocytosine (BoPhpC)-PNA, we e

23 ation was promoted by 2-pentenal and also by o- and p-diphenols, but not by m-diphenols.

24 similar in < 10 nM Ca2+o and 100 microM Ca2+o (between 1 and 2 ms).

25 ut 45 ms in micromolar concentrations of Ca2+o (1-100 microM).

26 g (CS) and contractile responsiveness to Ca2+o ([Ca2+]o from(0) to 2 mM) in ARVM.

27 ude of Icat and the potency sequence was Ca2+o > Sr2+o > Ba2+o.

28 s increased without increasing average [Ca2+]o (by increasing sarcomere length), [NADH]m fell similar

29 H]m (since [NADH]m rapidly fell) or by [Ca2+]o (since work could also be increased at constant [Ca2+]

30 y were applied: cation concentrations ([Ca2+]o = 2 mM, [Mg2+]o = 1.7 mM, [K+]o = 3 mM) and recording

31 The present study found that elevated [Ca2+]o (2.5 mmol/L) enhanced proliferation of skeletal metast

32 A decrease in [Ca2+]o (from 2 to 1 mM) and an increase in [Mg2+]o (from 2 to

33 al amplification, while an increase in [Ca2+]o (from 2 to 8 mM) generated this behaviour in neurones

34 At extremely low [Ca2+]o (< 0.005 mM), morphine paradoxically increased BrdU in

35 A synthesis by increasing [Ca2+]i; low [Ca2+]o (0.3 mM) blocked this effect, while treatment with Ca2

36 r in Ringer's solution containing 1 mM [Ca2+]o + 50 microM verapamil (tg = 49.3 +/- 3.8 minutes).

37 ), which was blocked by nominally zero [Ca2+]o (n = 4) or by ICS205-930 (1 microM, n = 4).

38 Two candidates, o-(18)F-1 and p-(18)F-2, showed optimal brain uptake, fa

39 (in millimoles per liter per second) at [Cl-]o = 75 mmol/L (newborns; 0.15 +/- 0.04; weanlings; 0.2 +

40 ), elimination of the drug from the colon ( o ), fifty percent sensitive bacteria (P. multocida) kil

41 The gold chlorostibine complex ((o-(Ph2P)C6H4)2SbCl)AuCl (1-Cl) undergoes a clean oxidati

42 e corresponding trichlorostiborane complex ((o-(Ph2P)C6H4)2SbCl3)AuCl (2-Cl), which can be converted

43 t cleanly into the platinum germyl complex [(o-(Ph(2) P)C(6) H(4) )(2) ClGe(III) ]Pt(I) Cl with quant

44 he tetravalent platinum stiboranyl complex [(o-(Ph2P)C6H4)2(o-C6Cl4O2)Sb]PtCl2Ph (2) has been synthes

45 ford the dicationic chlorostibine complex [((o-(Ph2P)C6H4)2SbCl)PtCNCy](2+) ([3](2+)) as a bis-trifla

46 ily converted into the dicationic complex [((o-(Ph(2) P)C(6) H(4) )(2) (o-Ph(2) PO)C(6) H(4) )SbAuCl]

47 This complex, ((o-(Ph2P)C6H4)2SbOTf2)PtCl (2), which was obtained by tre

48 nthetic agonists Ace-Trp-Lys[NH(epsilon)CONH-o-(MePh)]-Asp-MePhe-NH(2) (GI5269) and the C1 N-isopropy

49 In contrast, o- and di-o-methoxy substituents significantly accelerat

50 SCs) were synthesized from the corresponding o- and p-nitro protecting group.

51 hyl)-2-nitroresorcinols to the corresponding o-(alkoxy-substituted) arylmethylnitrophenols.

52 ted), with selectivity for the corresponding o-(n-alkyl)toluene.

53 nto nuclear gene exons encoding the critical o- and n-subunits of NDH, respectively.

54 malous mole fraction effects observed for Cs+o + K+o mixtures, suggest that DR channels select for K+

55 s 31 pS at -67 mV with [Na+]o = 140 mM, [Cs+]o = 5 mM, [Na+]i = 88 mM, and [Cs+]i = 74 mM.

56 H also repressed the proton pumps cytochrome o (cyo) and NADH dehydrogenases I and II.

57 213 at 25 degrees C, corresponding to DeltaG'o = +2.3 kcal mol-1.

58 lic cyclization of the resulting N,N-dialkyl-o-(1-alkynyl)anilines using I2 in CH2Cl2.

59 d 3-iodobenzofulvenes (from beta,beta-diaryl-o-(alkynyl)styrenes) in good yields under mild reaction

60 of chloro-, nitro- dichloro-, and dinitro- (o-, m-, and p-) benzene guests.

61 hoxy-6-methyl-5,6,7,8-tetrahydro[1,3]-dioxol o-[4,5-g]isoquinolin-5-yl)isobenzo-furan-1(3H)-one (nosc

62 tom of the tridentate diphosphinobismuthine (o-(Ph(2)P)C(6)H(4))(2) BiCl behaves as a Z rather than L

63 III)Pt(I)Cl(o-dppp)(2)](+) ([1](+), o-dppp = o-(Ph(2)P)C(6)H(4)) by reaction of the new bis(phosphino

64 ed Cl2Sb(IV)Pt(III)Cl3(o-dppp)2 (2, o-dppp = o-(Ph2P)C6H4)), a complex featuring a highly oxidized [P

65 sized [Cl3Sb(V)Pd(II)Cl2(o-dppp)2] (o-dppp = o-(Ph2P)C6H4), a palladium dichloride complex featuring

66 ndoergic charge separation products (Delta E o = -0.6 V) remain after several minutes, which points t

67 sence of a tetraheme, low-redox-potential (E'o = -233 mV), cytochrome c-type cytochrome with a molecu

68 em representing one of these families, i.e., o- and p-xylene as aromatics, 1-octene as an alkene, and

69 lide or benzamide bonds were prepared (i.e., o-, m-, p-poly-1 and poly-2 series) and characterized bo

70 ime for the protein, phi p, of 4.7 ns; r(eff)o = 0.214 and phi p = 4.2 ns for the FKBP12/FK506 comple

71 mental evidence for the formation of elusive o-(MV(+))(2) dimeric species.

72 o- and bromo- substituted end groups (IC-FBr-o & IC-FBr-m), which were then employed to construct two

73 .1 nmol/min/ mg of protein were obtained for o-, m-, and p-cresol oxidation by wild-type T4MO, which

74 of these reactions indicate a preference for o- over p-substitution for electron donating groups, wit

75 the level of MMFF, theory predicts that for o- or m-oligophenylene ethynylenes, helix formation is e

76 The compounds are derived from o- and p-amino and p-methylamino aniline nitrogen mustar

77 effect on cross-linking in progressing from o- to p-PDM was on the alphagammagamma trimer, which is

78 f dimerization in the range 0.02 M < or = [G]o < or = 0.09 M.

79 ucleus (DRN), feedback activation by Galphai/o -coupled 5-HT1A autoreceptors reduces the excitability

80 l-based assays these dimers regulate Galphai/o- and Galphaq/11-mediated pathways.

81 shift in the product distribution, and gave o- and p-cresol in a 1:1 ratio.

82 it eosinophil migration in a CB2 receptor/Gi/o -dependent manner.

83 d (in COS-7 cells) with several different Gi/o- or Gs-coupled receptors, and ligand-induced increases

84 by designer drugs) receptors, we enhanced Gi/o- or Gs-protein-mediated signaling selectively in direc

85 lycosides is presented using stable glycosyl o-[1-(p-MeO-Phenyl)vinyl]benzoate (PMPVB) donors and emp

86 cationic, o-N,N,N-trimethylanilinium groups (o-[N(CH(3))(3)](+)) has recently been used to catalyze t

87 extracellular proton concentrations ([H(+) ]o ) on mouse TMEM16A expressed in HEK-293 cells using wh

88 inactive, and 2- and 3-hydroxyphenylalanine (o- and m-tyrosine) were inactive.

89 d by distinct classes of receptor (G(alpha)i/o- and G(alpha)q-coupled), providing dynamic regulation

90 biologically and pharmaceutically important o-(dimethylamino)aryl ketones, acridones, acridinium sal

91 lethanol, alpha-ionone, 3-methyl-1-indanone, o-(chloromethyl)phenyl sulfoxide, o-(bromomethyl)phenyl

92 tion of (o-(Ph2P)C6H4)3SbNi(PPh3) (1) into [(o-(Ph2P)C6H4)3ClSb]NiCl (2) is accompanied by a conversi

93 more phytotoxic than its structural isomers o- and p-tyrosine.

94 Three disubstituted benzene isomers ( o-, m-, and p-fluorophenyl piperazine) containing the di

95 ward current when extracellular K(+) ([K(+) ]o ) was increased.

96 -80 mV), via equilibration with 145 mm [K(+)]o (depolarization to approximately -5 mV), or during int

97 With saturating Na+i or K+o (150 and 15-20 mM, respectively), Ip was still stimula

98 At [K+]o = 18 mmol/L, slow action potentials generated by ICa(L

99 from neonatal rat hippocampus (20-22 C; [K+]o = 2.5 mM) revealed two previously recorded non-inactiv

100 Elevated [K+]o (30 or 40 mM) or phorbol esters (0.5 microM) also inhi

101 Elevation of extracellular [K+]o (from 5.9 to 12 mM) brought membrane potentials closer

102 Increased [K+]o (5-10 mM) in the superfusion, producing modest depolar

103 bellum, cultured in physiological levels [K+]o (5 mM) for 14 days, loose the majority of granule cell

104 Lower [K+]o (2.7 mM) reduced the steady state slope conductance as

105 further increased; SGN survival in 80 mM [K+]o (80K) is poor relative to survival in 30K.

106 being greater than that evoked by 20 mM [K+]o (which did cause constriction).

107 tions ([Ca2+]o = 2 mM, [Mg2+]o = 1.7 mM, [K+]o = 3 mM) and recording temperature (30-32 degrees C) we

108 hidin currents were smaller in a reduced [K+]o (EC50 = 0.2 mM).

109 Accordingly we have named them K-o ("koniocellular-orientation") cells.

110 when cells were depolarized by elevated [KCl]o (>12 mm).

111 High [KCl]o (65 mM) induced nearly comparable vasoconstriction to

112 depolarized (11-20 mV) by elevation of [KCl]o (12-20 mm).

113 nide bonding(15), concentrating on localized o-, n-, and d-bonding models paralleling d transition me

114 mologs of the barley mildew resistance locus o (MLO) protein biochemically shown to have a seven-tran

115 We found that maj-o (1) treatment presents potent cytotoxicity in various

116 the marine NP majusculamide D, majusculamide o (maj-o, 1), that has remarkable potency and selective

117 al and free software packages yielded a mean o = 51.1(4)%, ranging from 45.3(6)% for hexane to 60(1)%

118 significantly higher mean number of medium (o = 0.1 to 0.5 mm, P = 0.03), and large vessels (o >= 0.

119 ]o (from 2 to 1 mM) and an increase in [Mg2+]o (from 2 to 10 mM), or the addition of Ni2+ (2-3 mM), a

120 cation concentrations ([Ca2+]o = 2 mM, [Mg2+]o = 1.7 mM, [K+]o = 3 mM) and recording temperature (30-

121 ociations were reported for dioxin-like mono-o- and non-o-PCBs as well as for nondioxin-like estrogen

122 This allows the generation of 3 x (m + n + o + p) different peptide topologies because the fourth c

123 h cysteine can appear in any of the (m + n + o + p) randomized amino acid positions (X).

124 hanediyl bismethanethiosulfonate (3 A), N,N'-o- phenylenedimaleimide (6 A) and N,N'-p-phenylenedimale

125 he catalyst under mildly basic conditions, N-o-(trifluoromethane)benzenesulfonyl aziridine was effici

126 ted by a 10-fold molar excess over PDM of N-(o- and p-tolyl)succinimide, which are chemically inert s

127 n transient currents measured at normal Na(+)o (QNa).

128 e non-inactivating currents with Na+i and Na+o (0 K+).

129 ry conductance was 31 pS at -67 mV with [Na+]o = 140 mM, [Cs+]o = 5 mM, [Na+]i = 88 mM, and [Cs+]i =

130 two approaches: first, introduce a nitrogen o- or p- to the 3-OH group in the phenyl ring; second, r

131 henoxide anions by collisional activation of o-, m-, and p-nitrobenzoate.

132 adical anions and the electron affinities of o- and m-benzoquinone.

133 Electron affinities of o- and p-quinoniminyl radicals are measured to be 1.715

134 r than solvent, giving only trace amounts of o-/p-chloro adducts upon addition of chloride trap.

135 Radical anions of o-, m-, and p-benzoquinone were produced in a Fourier tr

136 The tert-butylimines of o-(1-alkynyl)benzaldehydes and analogous pyridinecarbald

137 The Suzuki-Miyaura couplings of o-, m-, and p-halophenols with o-, m-, and p-phenol boro

138 Richter cyclization of o-(1,3-butadiynyl)phenyltriazene produced 3-alkynyl-4-br

139 Structures and energetics of o-, m-, and p-quinonimide anions (OC6H4N(-)) and quinoni

140 cycles, we derived heats of hydrogenation of o-, m-, and p-benzoquinone (Delta(hyd)H degrees (1o, 1m,

141 he CYP4B1-mediated benzylic hydroxylation of o- and p-xylenes were fully expressed (k(H)/k(D) = 9.7 a

142 Mannich reaction performed on Boc-imines of o-(azidomethyl)benzaldehydes, followed by a one-pot Stau

143 n established sequence of iodocyclization of o-(buta-1,3-diynyl)thioanisoles followed by Sonogashira

144 res is varied systematically using a pair of o-, m-, or p-xylylene (o-, m-, or p-Xy) covalent linkers

145 chieved by stereoselective quaternization of o-(pinacolato)boronatophenylphosphine with beta- or gamm

146 mild reaction conditions by the reaction of o-(1-alkynyl)benzamides with ICl, I(2), and NBS.

147 mild reaction conditions by the reaction of o-(1-alkynyl)benzoates and (Z)-2-alken-4-ynoates with IC

148 ed on the 5-endo iodocyclization reaction of o-(alkynyl)styrenes, represents one of the scarce exampl

149 The reaction of o-(allyloxy)iodobenzene with [(phen) 2Cu][Cu(pyrr) 2] re

150 ailed analysis for this reaction a series of o-(2'-imidazolyl)naphthyl (4-nitrophenyl) phosphate isom

151 The first singlet excited states of o- and p-amino GFPSCs carry significant charge-transfer

152 Similar treatment of o- and p-(hydroxymethyl)benzoate derivatives results lar

153 data, it is shown that PhICl2 oxidation of (o-(Ph2P)C6H4)3SbNi(PPh3) (1) into [(o-(Ph2P)C6H4)3ClSb]N

154 rd this end, the dangling phosphine arm of ((o-(Ph(2) P)C(6) H(4) )(3) )SbCl(2) AuCl (1) was oxidized

155 Cl (2), which was obtained by treatment of ((o-(Ph2P)C6H4)2SbCl2)PtCl (1) with 2 equiv of AgOTf, is s

156 the Pt center, results in the formation of [(o-(Ph2P)C6H4)2(o-C6Cl4O2)SbF]PtClPh (3).

157 xyl isocyanide results in the formation of [(o-(Ph2P)C6H4)3(o-O2C6H4Sb)]Ni(CNCy) (4), a complex featu

158 ine, we have studied the photochemistry of [(o-(Ph(2) P)C(6) H(4) )(2) Ge(IV) Cl(2) ]Pt(II) Cl(2) and

159 Ph (2) has been synthesized by reaction of [(o-(Ph2P)C6H4)2SbClPh]PtCl (1) with o-chloranil.

160 of future chemosensing technologies based on o-(N,N-dialkylaminomethyl)arylboronate scaffolds that ar

161 ect that is not shown in single-phase (h- or o-) LFO.

162 hydroxy-4-(4'-phenoxy)-1butenyl)-7-oxabicycl o-[2.2.1]heptan-2-yl]-5-heptanoic acid, an agonist, with

163 day 1 = 59.0 6 27.0 vs. day 5 = 4.0 6 5.5, p o .05) as well as in comparison to the untreated control

164 0.9% for separation factor (for solute pair o- and p-xylene).

165 substituents (isopropyl, cyclohexyl, phenyl, o- or p-nitrophenyl) in beta anomeric configuration exhi

166 ,4-diynes in which the aryl group is phenyl, o-(methoxy)phenyl, or p-(methoxy)phenyl.

167 Protein tyrosine phosphatase o (PTPo, PTPRS), a receptor for PNNs, interacts with TRK

168 ther found that protein tyrosine phosphatase o (PTPo, PTPRS), receptor for CSPGs, interacts with TRKB

169 ologous recombination rely on DNA polymerase o (pol o) for repair of DNA double-strand breaks.

170 The translesion DNA polymerase o (Polo) carries a large insertion sequence in its catal

171 We show that DNA polymerase o (POLo)-mediated end joining (TMEJ) repairs DSBs arisin

172 suggests that in Arabidopsis, DNA polymerase o (PolQ) may be a crucial enzyme involved in T-DNA integ

173 teractions between the atomically positioned o-[N(CH(3))(3)](+) groups and the bound substrate.

174 of this precursor show rearranged protonated o-/p-aminophenols and solvent water adducts (catechol, h

175 kcal/mol, and delta G el= -2.8 kcal/mol (psi o = -30 mV).

176 lipid content = 40% (surface potential, psi o =-30 mV), conditions for which the protein has high ac

177 ) and KRT13 (PAML = 1.67 x 10 (-) (4); PSKAT-o = 1.07 x 10 (-) (5)), reaffirming variant-level analys

178 uded ACTBL2 (PAML = 3.23 x 10 (-) (5); PSKAT-o = 9.23 x 10 (-) (4)) and KRT13 (PAML = 1.67 x 10 (-) (

179 yrins wherein A = pentyl and B/C = pyridyl ( o-, m-, p-).

180 t electrophilic cyclization of the resulting o-(1-alkynyl)thioanisole derivatives.

181 S)-o- and (S)-m-methylphenylalanine; and (S)-o- and (S)-p-bromophenylalanine at preparative scale, si

182 s (S)-m- and (S)-p-methoxyphenylalanine; (S)-o- and (S)-m-methylphenylalanine; and (S)-o- and (S)-p-b

183 mplex of the Schiff base of glycine with (S)-o-[N-(N-benzylprolyl)amino]benzophenone and (S)- or (R)-

184 f the chiral Schiff base of glycine with (S)-o-[N-(N-benzylprolyl)amino]benzophenone.

185 dition where the substrate concentrations [S]o << Km.

186 electron-donating amino groups onto a simple o-(phenylazo)aniline platform dramatically accelerates i

187 d the corresponding cationic gold species [((o-(Ph2P)C6H4)2SbCl)Au](+) ([1](+)) and [((o-(Ph2P)C6H4)2

188 cat and the potency sequence was Ca2+o > Sr2+o > Ba2+o.

189 ins bearing three heterocyclic substituents (o-, m-, p-pyridyl) or four alkyl groups (ethyl, propyl,

190 e Pd-catalyzed cross-coupling of substituted o-(pseudo)halobenzoates and hydrazines with isocyanide i

191 -indanone, o-(chloromethyl)phenyl sulfoxide, o-(bromomethyl)phenyl sulfoxide, and ethyl p-tolylsulfon

192 c, vanillic, caffeic, chlorogenic, syringic, o- and p-coumaric, ferulic, rosmarinic, and tr-cinnamic

193 tion of the new bis(phosphino) telluroether (o-(Ph(2)P)C(6)H(4))(2)Te with (Et(2)S)(2)PtCl(2).

194 cal mol(-)(1), respectively, indicating that o- and p-benzoquinone should be excellent radical traps.

195 The o- and p-amino green-fluorescence-protein synthetic chro

196 The o-, m-, and p-phenylene bis(1,3-dioxolanium) dications (

197 A novel 1,4-palladium migration between the o- and o'-positions of biaryls has been observed in orga

198 The dianions are analogous to o-, m-, and p-benzyne and have the special feature of di

199 ere successfully performed while undermining o- and m-C-H activation.

200 ) and tetrameric (3) PACs with unprecedented o- and p-benzoquinone motifs (benzoquinonoid PACs).

201 arynes generated by the treatment of various o-(trimethylsilyl)aryl triflates with CsF results in [4

202 0.1 to 0.5 mm, P = 0.03), and large vessels (o >= 0.5 mm, P = 0.02).

203 The most potent of these compounds was o-(acetoxyphenyl)hept-2-ynyl sulfide (APHS).

204 ddition of a variety of diazo compounds with o-(trimethylsilyl)aryl triflates in the presence of CsF

205 ) complex of the Schiff base of glycine with o-[N-alpha-picolylamino]acetophenone, as a nucleophilic

206 )-complex of the Schiff base of glycine with o-[N-alpha-pycolylamino]acetophenone and (S)- or (R)-3-(

207 couplings of o-, m-, and p-halophenols with o-, m-, and p-phenol boronic acids were investigated for

208 mu-H)(mu-SC(6)H(4)X)(CO)(10) (2-X, where X = o-, m- or p-NH(2); o-, m- or p- OH; p-H, -Br, -NO(2), -C

209 cally using a pair of o-, m-, or p-xylylene (o-, m-, or p-Xy) covalent linkers to produce o-ExBox(4+)

210 cer), and 42.3% (GI cancer); mean age 60.3 y/o (range: 40-77); average > 3 years since last chemother

211 rifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl](o- tolyl)methanone (18).