ライフサイエンスコーパス: octamer

1 A-binding protein, non-POU-domain-containing octamer).

2 several aggregates (from dimers to at least octamers).

3 matin remodeler, SNF2h, distorts the histone octamer.

4 tely 1.7 times around a central core histone octamer.

5 mer and all of its oligomeric forms up to an octamer.

6 nucleotides 4-7, on the 3' flank of the Chi octamer.

7 spectroscopic characterization of the water octamer.

8 Spr3-Cdc3-Cdc10-Cdc10-Cdc3-Spr3-Spr28 hetero-octamer.

9 achieved, as well as the two-fold symmetric octamer.

10 /H2B dimers that remains associated with the octamer.

11 al made up from DNA wrapped around a histone octamer.

12 ding sites changes the product to the cyclic octamer.

13 oils of DNA wrapped around a central histone octamer.

14 rmation remained associated with the histone octamer.

15 dictates how DNA is wrapped around a histone octamer.

16 lation on the lateral surface of the histone octamer.

17 cilitating uncoiling of DNA from the histone octamer.

18 its left-handed wrapping around the histone octamer.

19 A is hindered by the presence of the histone octamer.

20 nucleosomal DNA partially uncoiled from the octamer.

21 affinity of these sequences for the histone octamer.

22 tal structure of ligand 10 shows it to be an octamer.

23 the formation of either the heptamer or the octamer.

24 water molecule in the classical cyclic water octamer.

25 intercalate between the DNA gyre and histone octamer.

26 ide of nucleosomal DNA away from the histone octamer.

27 extension plot and a >90 degrees flip of the octamer.

28 homochiral preference of the neutral serine octamer.

29 DNA minor groove faces away from the histone octamer.

30 around a positively charged histone protein octamer.

31 into stacks of desired size from dimer up to octamer.

32 to the same extended surface of the histone octamer.

33 eir monomeric and oligomeric forms up to the octamer.

34 l evolution in order to restrict assembly to octamers.

35 amers but failed to produce an intasome with octamers.

36 ents are assembled from apolar septin hetero-octamers.

37 d the core domain/lateral surface of histone octamers.

38 nces predicted to better accommodate histone octamers.

39 splay properties consistent with left-handed octamers.

40 one DNA molecule wrapped around two histone octamers.

41 at complement each other to exclusively form octamers.

42 ions of low salt and urea that dissociate H3 octamers.

43 th tunable ring size ranging from trimers to octamers.

44 thylation at R17 in CARM1-methylated histone octamers.

45 1-452) to form hydrodynamically well-behaved octamers.

46 force-induced unwrapping of DNA from histone octamers.

47 istone marks, and a region devoid of histone octamers.

48 the relative proportions of PA heptamers and octamers.

49 arated from the two subclasses forming R1-R2 octamers.

50 ) Cdc10-less hexamers natively co-exist with octamers.

51 N tetramers in contrast to one possessing IN octamers.

52 in structure by sliding and evicting histone octamers(3-8), creating DNA regions that become accessib

53 eric tetramers enabled assembly of SpyAvidin octamers (8 subunits) or eicosamers (20 subunits).

54 proximately two base pairs along the histone octamer accommodates the necessary DNA lifting from the

55 ch were experimentally found to have histone octamer affinities comparable to the highest-affinity se

56 her they face inward or outward from histone octamers along the DNA helix axis.

57 cells, genomic DNA is wrapped around histone octamers (an H3-H4 tetramer and two H2A-H2B dimers) to f

58 sensor selectively discriminated between the octamer analyte and another peptide of the same number o

59 ting tetramers can then interact, forming an octamer and a loop of the intervening DNA.

60 The placement of SWI/SNF between the octamer and DNA could make it easier to disrupt histone-

61 mediate key interactions between the histone octamer and DNA in forming the nucleosomal particle.

62 ed to refold together, the mixture formed an octamer and exhibited rapid fibrillation kinetics, simil

63 moter transcription and the distance between octamer and proximal sequence element of U6 promoter is

64 ng of two DNA duplexes wrapped around a Cse4 octamer and separated by a gap efficiently split into he

65 ctive and inactive conformations in both the octamer and the filament.

66 on of the catalytic core between the histone octamer and the unwrapped segment of DNA.

67 For example, both singly protonated serine octamers and anionic octamers complexed with two halogen

68 mutation was found in the interface between octamers and destabilized both monomeric and octameric r

69 However, based on this septin organization, octamers and hexamers would not be expected to copolymer

70 mes assembled with human recombinant histone octamers and nucleosome-positioning DNA containing cyclo

71 ons is that CENP-A nucleosomes cycle between octamers and tetramers in vivo.

72 retention, however a subset are secreted as octamers and the cause of their pathology is ill-defined

73 four transmembrane helices into channels of octamers and undecamers, respectively.

74 neutralizing the acidic patch of the histone octamer), and the removal of histone tails were investig

75 e lesions relative to the underlying histone octamer, and (iv) the distance between the lesion cluste

76 exists in monomer, dimer, tetramer, hexamer/octamer, and higher oligomeric forms that may be importa

77 two DNA molecules wrapped around two histone octamers, and an altosome complex that contains one DNA

78 sheets that further associate into hexamers, octamers, and dodecamers: the hexamers are trimers of di

79 brane protrusion sites harbor VP40 hexamers, octamers, and higher order oligomers.

80 The cyclic hexamer and octamer are predicted by density functional theory to ad

81 in lymphocytes and neural tissues, in which octamers are abundant but hexamers are rare.

82 ll the chemical steps of transposition, only octamers are active in vivo.

83 on of Abeta(1-42) in the sample, Abeta(1-42) octamers are also formed, made by two Abeta(1-42) tetram

84 We also find that histone octamers are easily transferred in trans from ssNucs to

85 rallel NCCN and especially the parallel NCNC octamers are stable and exhibit a favorable binding ener

86 ers: the hexamers are trimers of dimers; the octamers are tetramers of dimers; and the dodecamers con

87 e SEPT7-SEPT6-SEPT2-SEPT2-SEPT6-SEPT7, while octamers are thought to have the same core, but with SEP

88 Transcription factors (TFs) and histone octamers are two abundant classes of DNA binding protein

89 which consist of DNA wrapped around histone octamers, are dynamic, and their structure, including th

90 DNA looping mediated by the formation of CI octamers arising through the interaction of pairs of dim

91 1-286) determined whether an IN tetramer or octamer assembled with viral DNA.

92 pH but does not appear to be involved in the octamer assembly process.

93 Octamer assembly was shown to be a highly cooperative pr

94 It consists of a histone octamer associated with approximately 80 base pair (bp)

95 netics and thermodynamics of the DNA-histone octamer association that are required to remodel chromat

96 diester bonds by lifting DNA off the histone octamer at the site of integration.

97 These indicate that SARM1 homo-octamer avoids premature activation by assuming a packed

98 t CENP-A nucleosomes alter from tetramers to octamers before replication and revert to tetramers afte

99 dimers, which are in turn assembled into an octamer, best described as a tetramer of dimers.

100 elationship between DNA sequence and histone octamer binding affinity.

101 strength of both the chicken or frog histone octamer binding sites on each DNA, the results obtained

102 ny cells expressed stem cell markers such as octamer binding transcription factor 4 (Oct4) and stage-

103 amine rich (SFPQ), non-POU domain-containing octamer-binding protein (NONO), and RNA binding motif pr

104 riants are bound by the transcription factor octamer-binding protein 1 (Oct1/POU2F1) and TET2 and Oct

105 nt for the B-cell transcription factor OCT2 (octamer-binding protein 2, encoded by Pou2f2) in germina

106 ntrol of key pluripotency factors, including Octamer-binding protein 4 (Oct4) and Estrogen-related re

107 The transcription factor octamer-binding protein 4 (Oct4; encoded by POU5F1) has

108 r binding partners non-POU domain containing octamer-binding protein and splicing factor proline/glut

109 these cells expressed the stem cell markers octamer-binding transcription factor (Oct4) and stage-sp

110 quence analysis revealed a binding motif for octamer-binding transcription factor 1 (OCT-1) in the de

111 rase complex, and transcription factor OCT2 (octamer-binding transcription factor 2) bound cooperativ

112 K1/2) and AKT, as well as down-regulation of octamer-binding transcription factor 4 (Oct-4) expressio

113 Octamer-binding transcription factor 4 (OCT-4) is an imp

114 The octamer-binding transcription factor 4 (Oct3/4) is a mas

115 m from SALL4 TSS are within binding sites of octamer-binding transcription factor 4 (OCT4) and signal

116 Octamer-binding transcription factor 4 (Oct4) has been s

117 s, and this complex inhibits Sox2 binding to octamer-binding transcription factor 4 (Oct4)/Sox2 enhan

118 the pluripotency transcription factor Oct4 (octamer-binding transcription factor 4) plays an unappre

119 The expression levels of NANOG, octamer-binding transcription factor 4, and sex-determin

120 oligomeric models (ranging from pentamer to octamer), built by incremental addition of peptides to s

121 or the assembly of an intasome containing IN octamers but not for an intasome containing IN tetramers

122 2DeltaC) did not oligomerize to a hexamer or octamer, but formed a high molecular weight soluble aggr

123 splay low intrinsic affinity for the histone octamer, but its contribution to antagonizing RNA polyme

124 ationally phased with respect to the histone octamer by TG motifs.

125 observed in going from the serine monomer to octamer can be accommodated using a chemical model, grou

126 The octamer can provide not only multiple specific DNA-bindi

127 and histone combinations (H1, H2AH2B, H3H4, octamers) caused a dose-dependent aggregation of phospha

128 five septins comprise two species of hetero-octamers, Cdc11/Shs1-Cdc12-Cdc3-Cdc10-Cdc10-Cdc3-Cdc12-C

129 e two species of budding yeast septin hetero-octamers: Cdc11/Shs1-Cdc12-Cdc3-Cdc10-Cdc10-Cdc3-Cdc12-C

130 tions, which result in the formation of NSP2 octamer chains.

131 In the longest octamer, charge resonance vanishes and the cation is loc

132 itions results in unusually abundant gaseous octamer clusters that exhibit significant homochiral spe

133 e three-dimensional reconstruction of the NP/octamer complex generated by single-particle cryoelectro

134 but <=5.6% and ~0.6% of serine exists as an octamer complex in 10 mM and 100 muM solutions, respecti

135 ed integrase (IN), which forms a tetramer or octamer complex with the viral cDNA long terminal repeat

136 than that in the all-butadiyne-linked cyclic octamer complex, whereas the diatropic current in the 6+

137 ingly protonated serine octamers and anionic octamers complexed with two halogen ions strongly prefer

138 ts of 147 bp of DNA wrapped around a histone octamer composed of two copies each of the histones H2A,

139 pare a fully pai-conjugated cyclic porphyrin octamer, composed of both beta,meso,beta-edge-fused porp

140 show that it is a two-fold symmetric hetero-octamer comprising an intertwined network of subunits wi

141 t the complex between M2R and holo-Gi1 is an octamer comprising four copies of each, and that activat

142 two stacked rings of octamers, in which the octamers contain supercharged proteins of alternating ch

143 octameric build-up in solution and that this octamer contains a global shape that is significantly no

144 The octamer contains an H3-H4 tetramer and two H2A-H2B dimer

145 Here, we investigate anionic serine octamers coordinated with two chloride ions using a nove

146 We propose that such reshaping of the octamer core by Swi6 increases opportunities for multiva

147 opulation abundance of the protonated serine octamer decreases from 1% to 0.6% from the largest to th

148 re plastic than previously imagined and that octamer deformation plays different roles based on the t

149 where one SNF2h protomer promotes asymmetric octamer deformation to inhibit the second protomer, whil

150 Furthermore, SNF2h couples histone octamer deformation to nucleosome sliding, but the under

151 The other structure doesn't show octamer deformation, but surprisingly shows a 2 bp trans

152 a dimer that can swiftly oligomerize into an octamer depending on local protein concentrations.

153 leave a small portion of DNA attached to the octamer despite extended pulling.

154 Octamer dimerization is consistent with the adhesive fun

155 ucleotides, respectively, whereas the TbGMPR octamer dissociates into two tetramers when ATP is avail

156 Preventing octamer distortion by site-specific disulfide linkages i

157 nificantly inhibited ATP-independent histone octamer-DNA sliding.

158 are presumably tetramers and octamers, with octamers dominating above about 0.5 mM.

159 er, how DNA is propagated around the histone octamer during this process is unclear.

160 t, the model output matches the experimental octamer ee % when subliming solid serine with various in

161 ecedented series of dye stacks from dimer to octamer enabled a systematic study of the optical absorp

162 The CBS interacts with the histone octamer, engaging the H2A-H2B acidic patch in a manner s

163 ctive determination of an immunogenic gluten octamer epitope, PQQPFPQQ.

164 nce and absence of L-arginine and a tetramer-octamer equilibrium that shifted towards tetramers upon

165 M1 SAM (sterile alpha motif) domains form an octamer essential for axon degeneration that contributes

166 nucleosome sliding by SNF2h while promoting octamer eviction by the SWI-SNF complex, RSC.

167 In human cells, both hexamers and octamers exist, and crystallography studies predicted th

168 ping-rewrapping (breathing) dynamics and the octamer flips approximately 180 degrees and moves toward

169 The longer cross-link favors octamer formation, whereas the shorter one favors format

170 5T interferes with VP40 function by altering octamer formation.

171 c model where tetramers are intermediates of octamer formation.

172 e nucleosome and prevent dissociation of the octamer from the DNA while facilitating its mobility alo

173 DH trimers formed octamers in solution, each octamer harboring an amazing 192 c-type heme moieties.

174 spectrum confirms that the collected serine octamer has undergone chiral enrichment relative to the

175 NP-A nucleosomes have been shown to exist as octamers, hexamers, and tetramers.

176 rapping the nucleosomal DNA from the histone octamer (HO).

177 hrough their distal face, encage the histone octamer in a nucleosome-like conformation and prevent it

178 oligomers in most studied species and R1-R2 octamers in Escherichia coli To better understand the di

179 11) at the junctions between adjacent hetero-octamers in paired filaments is highly cooperative.

180 nd the isolated tandem SAM(1-2) domains form octamers in solution, and electron microscopy analysis r

181 iensis Interestingly, the HDH trimers formed octamers in solution, each octamer harboring an amazing

182 uantities of monomers, dimers, pentamers and octamers in the C-S-H structure are measured.

183 y of the E. coli RNR to form inhibited R1-R2 octamers in the presence of dATP but, unlike the E. coli

184 Here we report that Mit1 mobilizes histone octamers in vitro and requires ATP hydrolysis and conser

185 e 16-mer is composed of two stacked rings of octamers, in which the octamers contain supercharged pro

186 es extended surface areas encircling the gp1 octamer, indicating that DNA wraps around gp1 through ex

187 Notably, Abeta(1-42) tetramers and octamers inserted into lipid bilayers as well-defined po

188 we demonstrated that histones (H1 or histone octamers) interact with negatively charged bilayers and

189 ted either as the result of a rapid dimer-to-octamer interconversion on the chromatographic time scal

190 The serine octamer is separated from other neutral clusters in the

191 The deposited octamer is subsequently dissolved, and the solution is i

192 a charged, discrete worm-like chain, and the octamer is treated as a rigid cylinder carrying a positi

193 rus nonstructural protein NSP2, a functional octamer, is critical for the formation of viroplasms, wh

194 The octamer-like fold and its TBP-interacting region are sim

195 The octamer-like fold comprises the heterodimers Taf6-Taf9,

196 The core contains an octamer-like fold, flexibly links the enzymatic modules,

197 ubunits Taf5, Sgf73 and Spt20, and a histone octamer-like fold.

198 tially the histone components to assemble an octamer-like particle, and crosslinked octamers with hig

199 acktracks and nucleosomal DNA recoils on the octamer, locking Pol II in the arrested state.

200 strong homochiral preference in the neutral octamer (measured after its gentle ionization), while th

201 of polymerisation (or size) from trimers to octamers (monomers and dimers did not precipitate BSA),

202 ial affinity for an 8 bp DNA site termed the octamer motif, and are hence known as Oct proteins.

203 relevance for processes in which the histone octamer must be rapidly removed from or deposited onto t

204 Applied to recombinant histone octamers, NF1, and TBP in complex with DNA, our method i

205 lts indicate that the majority of protonated octamer observed in mass spectra under previous conditio

206 32 enzymes showed that formation of the SInv octamer occurs through a beta-sheet extension that seems

207 uples neighboring membranes together through octamer-octamer contacts, perhaps modulated by interacti

208 A monodisperse, C4-symmetric octamer of a guanine-perylene-3,4,9,10-bis(dicarboximide

209 mately 150 base pairs of DNA wraps around an octamer of core histones to form the nucleosome, the bas

210 An octamer of histone proteins wraps about 200bp of DNA int

211 of 147 bp of DNA wrapped around a symmetric octamer of histone proteins.

212 he nucleosome: 147bp of DNA wrapped about an octamer of histone proteins.

213 erent structures of tetramers, hexamers, and octamers of phosphorylated and unphosphorylated AMII mus

214 Here we isolated hexamers and octamers of specific composition from human cells and sh

215 resolved peaks could be observed for either octamer or dimer when analyzed at intermediate pH (5.5-6

216 , nucleosomes containing the canonical yeast octamer or, in particular, the Cse4 octamer were assembl

217 ed of IN subunits ranging from tetramers, to octamers, or to hexadecamers.

218 formed on several surfaces suggests that the octamer-pentamer defect motif acts as a flexible strain

219 The observation of octamer-pentamer rows in ice films formed on several sur

220 ls responded strongly and exclusively to the octamer peptide (173)SELEIKRY(180), HLA-B*44:03(+) indiv

221 Moreover, the octamer peptide bound more stably to HLA-B*18:01 than di

222 169)EECDSELEIKRY(180), which encompasses the octamer peptide.

223 Octamer plasticity may contribute to chromatin regulatio

224 ATP promotes octamer polymerization, whereas GTP promotes a compact,

225 from human cells and show that hexamers and octamers polymerize individually and, surprisingly, with

226 yeast septin complexes and how these hetero-octamers polymerize into filaments in solution and on Pt

227 The histone octamer presents different levels of constraints on BER,

228 tamer upon dimerization, suggesting that the octamer provides a stable interface for the construction

229 canonical and variant histone tetramers and octamers, providing theoretical quantifications and phys

230 Gemin2 forms oligomers spanning the dimer to octamer range.

231 EPT9 expression level directs the hexamer-to-octamer ratio, and that the isoform composition and expr

232 rate cell lines with controllable hexamer-to-octamer ratios and that express single SEPT9 isoforms, w

233 Here, we show that Cse4 octamers remain intact under conditions of low salt and

234 While the histone octamer remains intact, the DNA is lifted from the surfa

235 ations in the lateral surface of the histone octamer remains unclear.

236 the steric constraints placed by the histone octamer remains unknown.

237 An OCRE (OCtamer REpeat of aromatic residues) domain found in RBM

238 onine peptide only when it is seeded with an octamer replicator containing eight units of a serine bu

239 etic data suggest that formation of the beta-octamer represents a rate-limiting step in the assembly

240 nt of the lysosome, and a failure to form an octamer results in suboptimal catalytic activity (most l

241 ort the structure at 4.1 A, revealing double octamer rings not observed before.

242 ect rows made from face-sharing pentamer and octamer rings.

243 ree high-resolution crystal structures of an octamer RNA duplex [5'-GUA(f(5)C)GUAC-3']2 that have bee

244 eptamer (Saccharomyces cerevisiae) to hetero-octamer (Schizosaccharomyces pombe) to hetero-nonamer (M

245 Recruitment of Oct-1 protein to the octamer sequence of U6 promoter is critical for optimal

246 Mutation in octamer sequence significantly reduced the SB202190-stim

247 tion can be observed only in the presence of octamer sequence.

248 on of lateral surface lysines in the histone octamer serves as a crucial regulator of nucleosomal dyn

249 re on the interaction of NP with the histone octamer, showing that NP could bind sequentially the his

250 ed particle at the functional centromere and octamer-sized particles on chromosome arms, reconcile se

251 The integrase octamer solves a conundrum for betaretroviruses as well

252 The K1(S233L)/K10-1B octamer structure revealed S233L(K1) causes aberrant hyd

253 of PrP was also found to stabilize the beta-octamer, suggesting that it can influence susceptibility

254 l similarity among all simulated K18 and K19 octamers, suggesting that similar folding of K18/K19 may

255 which a stretch of DNA peels off the histone octamer surface as a result of thermal fluctuations or i

256 outer turn of DNA unwraps gradually and the octamer swivels about the taut linkers and flips a furth

257 New results show that FBN30 is a secreted octamer that binds to both P. berghei and clinically cir

258 6 bp of DNA wrapped around a histone protein octamer that controls DNA accessibility to transcription

259 o acid serine is known to form a very stable octamer that has properties that set it apart from serin

260 ched between two beta clamp rings to form an octamer that is stabilized by three discrete interfaces.

261 tural analyses revealed that TbGMPR forms an octamer that shows a transition between relaxed and twis

262 ntal unit of chromatin, comprising a protein octamer that wraps approximately 147 bp of DNA and has e

263 ne monophosphate dehydrogenase (IMPDH) forms octamers that polymerize into helical chains.

264 s partial unwrapping of DNA from the histone octamer; that the scaffolding protein XRCC1 enhances the

265 g the most to precipitate BSA (1000 mug) and octamer the least (50 mug).

266 dimer, and four dimers are assembled into an octamer through crystal symmetry.

267 votal role in stabilizing DNA binding to the octamer through direct interactions, core structural rea

268 locase domain to pump DNA around the histone octamer to enable sliding.

269 hrough its association with the core histone octamer to form the nucleosome core particle (NCP), a co

270 , NP was capable of transferring the histone octamers to DNA in vitro, assembling nucleosomes.

271 proteins EZH2 and SUZ12 as well as HDAC2 to octamer transcription factor 1 (OCT1) (POU2F1) binding s

272 a the activation of the transcription factor octamer transcription factor 1.

273 ly, active BRAF upregulates HMGCL through an octamer transcription factor Oct-1, leading to increased

274 pectrometry (ESI MS) to monitor the dimer-to-octamer transition as a function of both solution pH and

275 Notably, the heptamer-octamer transition proceeds through the acquisition of t

276 MS provides strong evidence of the dimer-to-octamer transition state that occurs when the analysis i

277 e conformational change in the retinoschisin octamer upon dimerization, suggesting that the octamer p

278 wave numbers, which were assigned to the h16 octamer via detailed isotope dilution experiments.

279 Protonated octamer was observed for all tip sizes with 10 mM serine

280 s of different macrocycle size (hexamers and octamers), we observed the emergence of hexamer replicat

281 -C-methyl guanosine incorporated into an RNA octamer were analysed by X-ray crystallography, and the

282 al yeast octamer or, in particular, the Cse4 octamer were assembled at distinct populations of locati

283 nins composed of epicatechin from monomer to octamer were isolated from cacao (Theobroma cacao, L.) s

284 lliptical cylinder of size hexa-, hepta-, or octamer, whereas MALS data indicate a hexamer.

285 The chimeric proteins form circular octamers, whereas the wild-type WzzB from S. flexneri wa

286 n the flux is sufficient, assembles into the octamer, which displays a much higher chiral purity than

287 of terminal nucleosomal DNA from the histone octamer, which increases DNA accessibility.

288 bilization is dominated by hexa-, hepta- and octamers, which conduct water, ions and small dyes.

289 ur findings lead us to propose that the NSP2 octamer with multiple enzymatic activities is a principa

290 A multifunctional RNA-binding NSP2 octamer with nucleotidyl phosphatase activity is central

291 The multifunctional enzyme NSP2, an octamer with RNA binding activity, is critical for virop

292 Comparison of the octamer with the hexadecamer structure indicated little

293 Crystal structure analyses of RNA octamers with (R)- or (S)-5'-C-methyl-2'-deoxy-2'-fluoro

294 Retinoschisin forms a dimer of octamers with each octameric ring adopting a planar prop

295 le an octamer-like particle, and crosslinked octamers with high affinity.

296 en K18 and K19 aggregates, here, K18 and K19 octamers with repeat 3 (R3) in U-shaped, L-shaped, and l

297 in this study were derived from pure histone octamers with their native marks.

298 compounds (ranging in size from dimers to an octamer) with 5-5 and/or beta-O-4 linkages, and three sy

299 These are presumably tetramers and octamers, with octamers dominating above about 0.5 mM.

300 tudies suggest one PLCbeta binds to one C3PO octamer without a change in the number of TRAX/translin