ライフサイエンスコーパス: octameric

1 yclic molecular aggregations, heptameric and octameric.

2 addition of substrate FolB is predominantly octameric.

3 merase extracted from spinach leaves is also octameric.

4 .5 s, at which time Abeta40 is approximately octameric.

5 of hydrazide A-B monomers self-assemble into octameric [2]-catenanes with high selectivity for [1(3)2

6 The classical type of KATP channel is an octameric (4:4) complex of two structurally unrelated su

7 The Huc catalytic subunits form an octameric 833 kDa complex around a membrane-associated s

8 rease in the proportion of AOX-HA present in octameric active AOX, suggesting that newly synthesized

9 Wza creates an octameric alpha-helical channel spanning the OM, but the

10 The quaternary structure of the enzyme is octameric and can be aptly described as a tetramer of di

11 We ranked all possible H-2K(b) octameric and H-2D(b) nonameric epitopes that span the g

12 herichia coli, followed by separation of the octameric and hexameric assemblies on an ion-exchange co

13 and activated ATP-PRTs from both the hetero-octameric and hexameric families.

14 e R240A hexamer supports the hypothesis that octameric and hexameric morpheeins of PBGS are very clos

15 s by EM confirmed that the heterooligomer is octameric and revealed that the subunits are arrayed in

16 at centromere nucleosomes are unlikely to be octameric and that the exposed surfaces holding the nucl

17 erminal tyrosines is very high in monomeric, octameric, and DNA-complexed TBP and comparable to that

18 An octameric aniline molecule ("octaniline") was incorporat

19 esent a crystal structure of a funnel-shaped octameric apoptosome complex from the nematode Caenorhab

20 The octameric architecture of the intasome of mouse mammary

21 The quaternary octameric arrangement of hBD2 is conserved in two crysta

22 ution method is exemplified by revealing the octameric arrangement of Xenopus nuclear pore complexes

23 Crystal forms of the octameric assembly formed by this sequence exhibit unusu

24 organisms, in the absence of magnesium, the octameric assembly is significantly destabilized, and th

25 The structure shows an octameric assembly of integrase, in which a pair of inte

26 tor although it does appear to stabilize the octameric assembly of the protein.

27 ATP-sensitive K+ channels are an octameric assembly of two proteins, a sulfonylurea recep

28 o-EM structure of human CALHM1, revealing an octameric assembly pattern similar to the non-mammalian

29 -hydroxymethyl-7,8-dihydropterin, reveals an octameric assembly similar to that seen in crystal struc

30 f dephosphorylated Wzc from E. coli shows an octameric assembly with a large central cavity formed by

31 each consist of two dimers, resulting in an octameric assembly.

32 an elongated structure which persists in the octameric assembly.

33 ith a dissociation constant of 4 muM, and is octameric at higher concentrations.

34 ylation and phosphate binding, the HisZ-HisG octameric ATP-PRT acquired the ability to initiate the s

35 Hetero-octameric ATP-PRTs consist of four HisGS catalytic subun

36 quaternary structures, hexameric and hetero-octameric ATRP-PRTs exhibit similar functional parameter

37 microtubule nucleation relies on the hetero-octameric augmin complex, but lack of structure informat

38 Crystal structures of McbBCD reveal an octameric B(4)C(2)D(2) complex with two bound substrate

39 We have determined the structure of the octameric bacterial form of PRK to a resolution of 2.5 A

40 cruciferin complex of Brassica napus has an octameric barrel-like structure, which represents a very

41 eukocidin B), a toxin that assembles into an octameric beta-barrel pore in the target cell membrane,

42 a tetramer, successfully recapitulating the octameric beta-peptide bundle complex Zwit-1F.

43 h the downstream half-site was the preferred octameric binding site of TR (TNAGGTCA).

44 acting polypeptides, which assemble into the octameric biogenesis of lysosome-related organelles comp

45 ide that assembles, with dysbindin, into the octameric BLOC-1 complex.

46 lices and displays a concentration-dependent octameric build-up in solution and that this octamer con

47 have a subunit composition equivalent to an octameric building block.

48 of residues from at least two strands of the octameric bundle structure.

49 rotational correlation time appropriate for octameric but not dimeric species.

50 Unlike exclusively octameric canonical H3 nucleosomes, CENP-A nucleosomes h

51 ull-length NS5 protein from dengue virus, an octameric cap-0 viral RNA substrate bearing the authenti

52 stent with in vitro evidence for left-handed octameric CenH3 nucleosomes.

53 NP-A and H3 nucleosomes, and report that the octameric CENP-A core particles and nucleosomes display

54 The results imply the octameric channels are stable.

55 The calculated conductance of octameric channels is markedly higher than the conductan

56 n to fully assembled and correctly regulated octameric channels.

57 The octameric Chi (chi) sequence is a recombination hotspot

58 tly reported x-ray crystal structure for the octameric chicken mitochondrial CK indicates that its nu

59 in the structure and function of dimeric and octameric CK: (a) presence of seven basic amino acids in

60 lar to results previously shown with the RSV octameric cleaved synaptic complex intasome produced wit

61 Serine forms neutral octameric clusters during sublimation, as demonstrated b

62 nced (by 120-fold), by formation of a hetero-octameric complex between CM and DAH7PS.

63 f phenylalanine specifically promotes hetero-octameric complex dissociation, with concomitant reducti

64 The exocyst is an evolutionarily conserved octameric complex involved in polarized exocytosis from

65 The exocyst is an octameric complex mediating vesicle targeting and tether

66 Histones form an octameric complex of basic proteins important in regulat

67 thological conditions.The KATP channel is an octameric complex of two unrelated types of subunit: a p

68 The exocyst is an octameric complex required for polarized secretion.

69 The structure of the surprising hetero-octameric complex reveals the close interaction between

70 ns, comprising a glycosylated D4 symmetrical octameric complex stabilized by an extensive disulfide n

71 The exocyst is a hetero-octameric complex that participates in tethering of vesi

72 iedl syndrome protein complex (BBSome) is an octameric complex that transports membrane proteins into

73 rentially bind RNA, provided they were in an octameric complex with H2A and H2B.

74 uvA was octameric in solution, and formed an octameric complex with the DNA junction.

75 ally desensitized 910-kD Class-2 PEPC hetero-octameric complex, arises from a tight interaction betwe

76 or this SUMO ligase include a subunit of the octameric complex, Smc5, and the DNA repair protein Yku7

77 t recruited to the PM sequentially but as an octameric complex.

78 show that the organization of hexameric and octameric complexes is inverted compared with its origin

79 acid, and exists in dimeric, tetrameric, and octameric complexes resistant to proteolysis.

80 They are octameric complexes, (SUR1/Kir6.2)(4), comprising sulfon

81 mposition that is consistent with the hetero-octameric configuration hypothesized for the related Mth

82 a change toward a significantly more compact octameric conformation.

83 An octameric consensus sequence with a conserved hexameric

84 omatin, individual nucleosome particles, nor octameric core histones reproduced any of these procoagu

85 re of full-length PaFS consists of a central octameric core of prenyltransferase domains, with the ei

86 key interactions at the heart of the CENP-A octameric core, wherein shearing of contacts within the

87 We also find that octameric Cse4 nucleosomes can be reconstituted in vitro

88 icroscopy reveals the formation of flexible, octameric cup-like structures, which are able to self-as

89 actions stabilizing tri-, tetra-, hexa-, and octameric cyclic peptoids (as free hosts and host-guest

90 No binding of adenyl DNG with octameric cytidyl DNA was observed, indicating that the

91 E contains two GATA-binding motifs and three octameric direct repeats.

92 lator-effector complex and is revealed as an octameric disc.

93 , which have been reported to be tetrameric, octameric, dodecameric, and hexadecameric, highlight how

94 rast, excitation of the mixtures of the homo-octameric donor and acceptor cages in solution did not l

95 ence of a strong ninth heptad interaction an octameric downstream half-site allosterically promotes R

96 w that Sec2p associates with the exocyst, an octameric effector of Sec4p involved in tethering secret

97 In plants GS is an octameric enzyme and is located either in the cytoplasm

98 dehydrogenase is an allosterically regulated octameric enzyme composed of four each of two homologous

99 dehydrogenase is an allosterically regulated octameric enzyme composed of four heterodimers of a cata

100 nase (IDH) of Saccharomyces cerevisiae is an octameric enzyme composed of four heterodimers of regula

101 ogenase (IDH) is an allosterically regulated octameric enzyme composed of two types of homologous sub

102 The packing of the octameric enzyme in this crystal form is unusual, becaus

103 The activated state of the octameric enzyme is characterized by an interstitial pho

104 The octameric enzyme possesses eight distinct binding sites,

105 odeaminase (FTCD), a 0.5 million Dalton homo-octameric enzyme, plays important roles in coupling hist

106 GS in plants is an octameric enzyme.

107 f wild-type (IDH1/IDH2) and IDH1/IDH2(C150S) octameric enzymes were conducted in the presence of dith

108 The octameric exocyst complex is associated with the junctio

109 We determined that the presence of an octameric exocyst complex is required for the formation

110 The evolutionarily conserved octameric exocyst complex tethers secretory vesicles to

111 es regulate the assembly interface of a full octameric exocyst complex through interaction with Sec5

112 The octameric exocyst complex, which tethers exocytic vesicl

113 coil interfaces stabilizing its 40-nm hetero-octameric fork architecture.

114 ned the steady state kinetics for the hetero-octameric form and characterized the active site by muta

115 .3 A, and the phosphoethanolamine (PE)-bound octameric form at 2.7 A.

116 tramer in solution and is transformed to its octameric form by autoacetylation.

117 The native octameric form has been refined at a resolution of 3 A,

118 orm found in all three kingdoms and a hetero-octameric form largely restricted to bacteria.

119 cal ultracentrifugation established that the octameric form of CrgA is the predominant species in sol

120 ore sensitive to neutralization by a soluble octameric form of the CD46 receptor, consistent with the

121 o) (M(pro)C) locks M(pro) into a hyperactive octameric form that is hypothesized to promote the early

122 U is essential for the proper assembly of an octameric form, a key conformational feature that determ

123 the purified enzyme was found to exist as an octameric form.

124 sts in an equilibrium between tetrameric and octameric forms in the typical concentration range and b

125 extrins effectively block the heptameric and octameric forms of PA(63) interchangeably, adding flexib

126 A non-immunogenic octameric fusion underwent rearrangements in vivo result

127 eviously determined at 3.3 A and revealed an octameric gating ring composed of eight intracellular li

128 nd-binding domains, the RCK domains, form an octameric gating ring in which Ca(2+) binding induces co

129 supporting the notion that the formation of octameric gating ring is a functionally relevant event i

130 hogen receptor glypican-3 (GPC3), forming an octameric glycoprotein complex.

131 lization which is present in all dimeric and octameric guanidino kinases.

132 s might interrupt the global condensation of octameric H3 arrays and present an asymmetric surface fo

133 Its perienteric fluid contains an octameric haemoglobin that binds oxygen nearly 25,000 ti

134 r any larger quaternary structure similar to octameric hBD2.

135 In the octameric Hda-beta clamp complex, the inability of Hda t

136 e with SEPT7-containing hexamers to generate octameric heteromers.

137 SEPT9, K562 cells contain both hexameric and octameric heteromers.

138 components, we find that CENP-C reshapes the octameric histone core of CENP-A nucleosomes, rigidifies

139 somes comprise ~147 bp DNA wrapped around an octameric histone protein core composed of two H2A-H2B d

140 h nucleosome is typically centered around an octameric histone protein core: one central tetramer plu

141 lculated average molecular mass of an intact octameric holoprotein.

142 Here, we reconstitute functional octameric human exocyst, demonstrating the basis for hol

143 Unbound MleRuvA was octameric in solution, and formed an octameric complex w

144 ur findings suggest that CID nucleosomes are octameric in vivo and that CID dimerization is essential

145 ssembly of wild-type cI was determined to be octameric, in agreement with Senear et al.

146 tones of two evolutionarily conserved hetero-octameric inner ring complexes.

147 crystallography, we determine an unexpected octameric integrase architecture for the intasome of the

148 We show that initial assembly of a small octameric intermediate is entropically driven, while fur

149 deduced amino-acid sequences for dimeric and octameric isoforms of creatine kinase (CK) from a protos

150 through membrane-embedded AQP0 in both its (octameric) junctional and (tetrameric) nonjunctional for

151 elongated, opposing (alphabeta gammadelta)2 octameric lobes.

152 ations into the biological relevance of this octameric M(pro) have stalled.

153 apping may provide insights into the role of octameric M(pro) in the early-stage viral replication of

154 e, this is the first report of a full-length octameric MCM helicase.

155 tion of higher order oligomers, of which the octameric McsB is essential for surviving stress situati

156 Bacterial phosphoribulokinases (PRKs) are octameric members of the adenylate kinase family of enzy

157 ric (sar-) and ubiquitous (ubi-) isoforms of octameric MiCK and muscle (M) and brain (B) isoforms of

158 The octameric MiCK cDNA is composed of 1703 nucleotides with

159 steps of dimerization that generate stable, octameric mini-filaments.

160 show that bipolar tetrameric, hexameric, and octameric minifilaments of AMII with the nonhelical tail

161 rminal 32 heptad repeats suffice to assemble octameric minifilaments; (4) A1378 is outside of the int

162 re demonstrated that the scattering curve of octameric MleRuvA in 65% and 100% 2H2O is explained by a

163 An octameric model channel has been constructed from the cr

164 f this enzyme family, the allosteric, hetero-octameric, NAD(+)-specific IDH from yeast in three forms

165 rom resolution reveal that ROOL RNAs form an octameric nanocage with a diameter of 28 nm and an axial

166 s, it has been debated whether the classical octameric nucleosomal arrangement of two copies of CENH3

167 nders with eight binding sites (representing octameric nucleosomal cores) into irregularly folded clu

168 ENP-A encodes enhanced distortability to the octameric nucleosome, which may allow for enhanced flexi

169 ed by the DNA sequence, leading to the final octameric nucleosome.

170 tible with symmetrical structures, including octameric nucleosomes and (Cse4/H4)2 tetrasomes.

171 els for hemisomes that briefly transition to octameric nucleosomes at specific cell cycle points or h

172 Reconstitution of octameric nucleosomes containing histones Cse4/H4/H2A/H2

173 some assembly factor, and that the resulting octameric nucleosomes do not contain Scm3 as a stably bo

174 , we find that CENP-A arrays are composed of octameric nucleosomes that assemble in a stepwise mechan

175 with its centromeric variant Cse4 results in octameric nucleosomes that organize DNA in a left-handed

176 lengths centered on 133 bp, consistent with octameric nucleosomes with DNA unwrapping at entry and e

177 one H3, human CENP-A chromatin complexes are octameric nucleosomes with two molecules of CENP-A at al

178 , yield one-half the dimensions of canonical octameric nucleosomes.

179 ease activity is subject to regulation by an octameric nucleotide sequence called chi.

180 assium channels (K(ATP) channels) are hetero-octameric nucleotide-gated ion channels that couple cell

181 We conclude that PA may form an octameric oligomeric state as a means to produce a more

182 in dimers and association of dimers to form octameric or decameric beta-barrels.

183 none (ANQ) were used to assemble either homo-octameric or mixed-ligand double cages.

184 The prototypic hetero-octameric OST complex from the yeast Saccharomyces cerev

185 izes" one or more components of the specific octameric outer and inner ring subcomplexes that then te

186 anasal immunization of C57BL/6 mice with the octameric OVA peptide and CT produced similar results wi

187 Both heptameric and octameric PA complexes can translocate LF and EF with si

188 maturely adopt the channel conformation, but octameric PA complexes remain in their soluble prechanne

189 LT complexes containing octameric PA possess enhanced stability, channel-forming

190 their ability to inhibit the heptameric and octameric PA(63) variants and PA(63)F427A mutant.

191 te more readily than LT complexes containing octameric PA.

192 te, we present the first structures of human octameric PAICS in complexes with native ligands.

193 inct types of G-interface present within the octameric particles, which must polymerize to form filam

194 A model of octameric pea PBGS was built to predict the location of

195 hese B cells, we developed a novel approach, octameric peptide display, to follow the dynamics and lo

196 Umami taste properties of a novel octameric peptide K(1)ADEDSLA(8) and its mutants p.A2G,

197 Arrays of octameric peptide libraries on cellulose paper were scre

198 -B8-restricted H-Y epitope is defined by the octameric peptide LPHNHTDL corresponding to aa residues

199 This octameric peptide was also presented on HLA-Cw1 with sim

200 s I MHC molecule HLA-A2 complexed with of an octameric peptide, Tax8 (LFGYPVYV), from human T cell ly

201 C pocket is responsible for the selection of octameric peptides as the preferred ligands for Kb and p

202 tides representing all possible hexameric or octameric peptides from the N. gonorrhoeae MS11 pilin se

203 , with weaker reactivity being seen with the octameric peptides in the other two VDs.

204 ins of mice reacted with several VD1 and VD3 octameric peptides, with weaker reactivity being seen wi

205 H-2Kb predominantly binds octameric peptides.

206 ctron microscopy reveals that Csx28 forms an octameric pore-like structure.

207 for bicomponent pore formation proposes that octameric pores, comprised of two separate secreted poly

208 reby forestalling the formation of complete, octameric pores.

209 factory formation is mediated in part by an octameric protein called NSP2.

210 The exocyst is an octameric protein complex essential for exocytosis and p

211 nclude the Sec5 component of the exocyst, an octameric protein complex implicated in tethering of ves

212 The exocyst is an octameric protein complex implicated in tethering post-G

213 The exocyst is an octameric protein complex implicated in the tethering of

214 The exocyst is an octameric protein complex required for tethering secreto

215 The exocyst is an octameric protein complex required to tether secretory v

216 The sec6/8 complex or exocyst is an octameric protein complex that functions during cell pol

217 ex, also known as the exocyst complex, is an octameric protein complex that has been implicated in te

218 The exocyst is an evolutionarily conserved octameric protein complex that tethers post-Golgi secret

219 The exocyst, an octameric protein complex, is an essential component of

220 yst, an essential phylogenetically conserved octameric protein complex.

221 Porphobilinogen synthase (PBGS) is a homo-octameric protein that catalyzes the complex asymmetric

222 c Ptr2, Ptr-H10 is a dimer; unlike Ptr2, the octameric Ptr-H16 poorly recruits TBP to the promoter, b

223 hibit distinguishing characteristics: unlike octameric Ptr2, Ptr-H10 is a dimer; unlike Ptr2, the oct

224 ct the remaining N-terminal structure of the octameric PTX3 complex, revealing two long tetrameric co

225 hydrate, occurs through an assembly of cubic octameric Q(3) (8) polyanions formed through cross-linki

226 we found that both proteins could assume an octameric quaternary structure in vivo.

227 d Acid-1Y* fold spontaneously into discrete, octameric quaternary structures that we refer to as beta

228 species, the recombinant spinach enzyme was octameric rather than dimeric, as assessed by gel filtra

229 ia coli, its activities are regulated by the octameric recombination hotspot, chi (5'-GCTGGTGG), whic

230 iring certain regions such as the Cu-binding octameric repeat region and the hydrophobic core.

231 The N-terminus of the protein contains an octameric repeat region with each of the four repeats co

232 However, the first binding is that to the octameric repeat region.

233 ng events occur at the fifth site and at the octameric repeat region.

234 ding events have lower affinities within the octameric repeat region.

235 a model was proposed for the structure of an octameric repressor that forms both in the presence and

236 Retinoschisin, an octameric retinal-specific protein, is essential for ret

237 octamers and destabilized both monomeric and octameric retinoschisin.

238 The data showed that endocytosis of the octameric RGD derivative was significantly higher by com

239 oschisin forms a dimer of octamers with each octameric ring adopting a planar propeller structure.

240 in the absence of nucleotide cofactor as an octameric ring and in the presence of ATP as a helical f

241 evidence for the association between one RCK octameric ring and two KtrB membrane proteins.

242 elicase from Pyrococcus abyssi in its single octameric ring assembly.

243 resence of ssDNA, Rep68 forms a large double-octameric ring complex.

244 sidues 12 to 60, depicts the formation of an octameric ring composed of antiparallel coiled-coil dime

245 structure of this protein in three different octameric ring conformations that resemble the RCK-domai

246 M(1-2) and found that it also forms a closed octameric ring in the crystal lattice.

247 m of activation and show that the RCK-domain octameric ring model is generally applicable to other io

248 and electron microscopy analysis reveals an octameric ring of SARM1.

249 ase-DNA complex reveals that Hermes forms an octameric ring organized as a tetramer of dimers.

250 cillus thermodenitrificans, showing a unique octameric ring with the potential to form a 16-meric sup

251 study, we found that SARM1 assembles into an octameric ring.

252 hus far only been observed to bind DNA as an octameric ring.

253 he pentraxin fold and a novel doubly stacked octameric ring.

254 1 but showed instead that this protein forms octameric rings and stacks of rings.

255 TRiC particle to be composed of two stacked octameric rings enclosing a folding cavity.

256 f Dronc-CARD that are sandwiched between two octameric rings of the Dark protein.

257 s hybrid ring structures where the OBD forms octameric rings while the HD forms heptamers.

258 first of a novel subclass of LTTRs that form octameric rings.

259 S1, a 16-mer composed of paired back-to-back octameric rings.

260 We show that hDmc1 forms octameric rings.

261 Novel features detected in the octameric RNA assembly include a new crystal form, evide

262 Cdc3, Cdc10, Cdc11, and Cdc12 form an apolar octameric rod with Cdc11 at each tip, which polymerizes

263 Septins form octameric rods that assemble into higher order filamento

264 hat Shs1 substitutes for Cdc11, resulting in octameric rods that do not polymerize into filaments but

265 septin protomers assemble into linear hetero-octameric rods with 2-fold rotational symmetry.

266 ARM1 ARM domain bound to NMN and of the homo-octameric SARM1 complex in the absence of ligands.

267 olecular dynamics simulations of PrP(90-231) octameric segments suggested that such linear fibrils, w

268 Thus, common octameric sequence elements are involved in periodic acc

269 We identified an evolutionarily conserved octameric sequence, CCCAGCAG, approximately 100 bases up

270 l gene regulation, including AP-1, GATA, and octameric sequences.

271 Translin is an octameric single-stranded DNA binding protein consisting

272 ein exists as a homodimer but converts to an octameric state in the mildly acidic environment of the

273 + binding stabilizes the RCK domains in this octameric state.

274 monomeric and tetrameric states but not the octameric state.

275 gomeric pore, which can assume heptameric or octameric states.

276 sight into the effect of the mutation on the octameric structure and biochemical activities of tsE NS

277 hose observed in vivo demonstrating that the octameric structure is physiologically relevant.

278 While this octameric structure is unique to both the phosphoribosyl

279 The octameric structure of MspA, its sharply defined constri

280 ouble mutation caused destabilization of the octameric structure of sMtCK and a profound reduction in

281 of protein-DNA complexes, translin forms an octameric structure that binds the DNA.

282 This revealed an octameric structure that strongly resembles that reporte

283 lorobium vibrioforme is shown to form a homo-octameric structure with 422 symmetry in which each subu

284 NP-A/H4)(2) tetramer is incongruent with the octameric structure, explaining many of the unusual dyna

285 To test the relevance of the octameric structure, we developed a new method to probe

286 Mitochondrial creatine kinases form octameric structures composed of four active and stable

287 rried out on 11 different hexa-, hepta-, and octameric systems.

288 partially shields the DNA binding saddle in octameric TBP, shifting upon dissociation to monomers to

289 To investigate the dynamic assembly of the octameric TPC at the plasma membrane (PM), we performed

290 asmuch as binding of activator protein-1 and octameric transcription factor 1 to DNA was not affected

291 MspA, an octameric transmembrane channel protein from Mycobacteri

292 ssociates stoichiometrically with the hetero-octameric Tubulin Chaperone Protein-1 (TCP-1) complex, w

293 ed that the heterodimers form multimers with octameric units in three potential arrangements, which m

294 PBGS from most organisms was believed to be octameric until work on a rare allele of human PBGS reve

295 The unusual hetero-octameric version of ATP-PRT includes four HisG(S) catal

296 eveal a new layer aggregation, L4(4)8(8), as octameric water aggregates in a stair conformation which

297 lly inhibited state shows that Gad1 forms an octameric web that encases the GajAB complex and inhibit

298 The former two CKs are either dimeric or octameric while FlgCKs are contiguous trimers consisting

299 cates that CENP-A-containing nucleosomes are octameric with conventional left-handed DNA wrapping, in

300 Like PurE, LarB is octameric with four active sites located at subunit inte