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1 peroxynitrite formation in response to this octapeptide.
2 T lymphocytes (CTL) to the fusion partner's octapeptide.
3 a transcription repression domain called the octapeptide.
4 ch contributes to hypertension caused by the octapeptide.
5 ased contractile response to cholecystokinin octapeptide.
6 o generate dose-response curves for the free octapeptide.
7 ion 4 in beta-sheet A of this serpin with an octapeptide.
8 Ki = 0.40 +/- 0.03 microM) than the starting octapeptide.
9 n Pax-B, having both the homeodomain and the octapeptide.
10 contain a paired-type homeodomain and/or an octapeptide.
11 roduct was identified as the SLVELTSL (SEL8) octapeptide.
12 s, ursodeoxycholic acid, and cholecystokinin-octapeptide.
13 rnifin beta contains 21 tandem repeats of an octapeptide.
14 ) supported a model for the synthesis of the octapeptide.
15 bling enabler, we generated a phosphorylated octapeptide.
16 or the lack of contacts normally made by the octapeptide.
17 the self-assembly of lanreotide, a cationic octapeptide.
18 ned with the upstream di-arginine-containing octapeptide.
19 (-1) for a small organic molecule and for an octapeptide.
20 (IC(50) = 2-4 nM) cyclic somatostatin (SRIF) octapeptides.
21 hown to be the case in 18-membered ring SRIF octapeptides.
22 various cancers expressing receptors for SST octapeptides.
23 ins of eight saccharides cross-linked by two octapeptides.
24 et bind to two and only two groups of nRNP A octapeptides.
25 mushrooms in the genus Amanita, are bicyclic octapeptides.
26 ravenous injection of either cholecystokinin octapeptide (200 mug/kg in 0.3 mL saline) or vehicle pla
27 ) selectivity, substitution of Trp(8) in the octapeptide 9 by imBzl-l- or -d-His(8) results in loss o
29 e obelin label in a controlled manner to the octapeptide, a fusion protein was produced using recombi
35 of poisonous Amanita mushrooms are bicyclic octapeptides (amatoxins) or heptapeptides (phallotoxins)
36 The cholecystokinin (26-33) [CCK (26-33)] octapeptide analog Asp-Tyr-D-Phe-Gly-Trp(N-Me)-Nle-Asp-P
37 though a number of synthetic hexapeptide and octapeptide analogs of SRIF bind selectively to SSTR2.
39 e-dimensional NMR structures of eight cyclic octapeptide analogues of somatostatin (SRIF) are describ
40 ative L,5D6 antagonist motif on somatostatin octapeptide analogues with a cyclic hexapeptide core.
42 tic secretion in response to cholecystokinin octapeptide and reduced pancreatic digestive enzyme prot
43 as gastrin/carboxy-terminal cholecystokinin octapeptide and selective cholecystokinin antagonists, c
44 ess responsive to vesicular stomatitis virus octapeptide and unresponsive to weak peptide agonists, a
45 Due to the high specificity of the displayed octapeptides and avidity effect of their multicopy displ
46 synthesized a library of over half a million octapeptides and exposed it to light and air in pH 7.4 b
47 ginyl endopeptidase, we prepared a series of octapeptides and mutant legumin B and G4 glycinin subuni
48 -scanning studies with overlapping deca- and octapeptides and polygonal rabbit and human infant immun
49 se activity (using hydrolysis of a synthetic octapeptide), and MMP-8 (using a Western blot) and the b
50 ability of other cyclic hexapeptides, cyclic octapeptides, and a cyclic nonapeptide is also investiga
51 (ELISA) screening against synthesized serial octapeptides, and ELISA screening, with anti-PM-Scl posi
55 ic forms of ACE both generate the vasoactive octapeptide angiotensin II (Ang II) with equal efficienc
56 eave angiotensin I (Ang I) to the vasoactive octapeptide angiotensin II (Ang II), but is also able to
59 d peptides of increasing size, including the octapeptide, angiotensin II, and the nonapeptide, oxytoc
61 ntification of novel disulfide-linked cyclic octapeptide antagonists of somatostatin is described.
63 d potential medical applications of a cyclic octapeptide as the first highly selective small-molecule
64 as solubilized by adding the very polar FLAG octapeptide (Asp-Tyr-Lys-Asp-Asp-Asp-Asp-Lys) to the N-t
65 of principle, we have appended an extraneous octapeptide at the N terminus of hepatitis B virus capsi
66 M were matched by incubating DC with cognate octapeptides at 1-10 pM, indicating that display of very
67 predicted to be essential for the binding of octapeptides based on the observation that SSTR1 can bin
70 entarity and greater number of contacts, the octapeptide binds with an affinity (KA = 2.5 x 10(5) M-1
72 H-2(b) mice specific for the VSV8 (RGYVYQGL) octapeptide bound to Kb, we identified a single weak ago
73 specific for the vesicular stomatitis virus octapeptide bound to the H-2K(b) molecule were compared
74 s high affinity for sulfated cholecystokinin octapeptide but has > or = 1000-fold lower affinity for
78 ubicin (AN-201) linked covalently to the SST octapeptide carrier RC-121 (D-Phe-Cys-Tyr-D-Trp-Lys-Val-
79 n applied to the discovery of a new class of octapeptide catalysts for the kinetic resolution of seco
81 for the ability of systemic cholecystokinin octapeptide (CCK) (0 or 10 microg/kg) to inhibit food in
82 Systemic administration of cholecystokinin octapeptide (CCK) slows gastric emptying, inhibits feedi
83 genic mice 5 min after 10 pM cholecystokinin octapeptide (CCK) stimulation was enhanced by 160% of co
84 2 mg/kg, i.p.), and sulfated cholecystokinin octapeptide (CCK-0.05 and 0.1 mg/kg, i.p.) were used to
86 cular (i.c.v.) injections of cholecystokinin-octapeptide (CCK-8) and somatostatin (SST) and the inter
88 by a continuous intravenous cholecystokinin octapeptide (CCK-8) infusion was determined by ultrasono
93 al injection of low doses of cholecystokinin octapeptide (CCK-8; 10-60 pmol); group B neurones respon
94 he density and distribution of sulphated CCK octapeptide (CCK8S) binding sites and preproCCK peptide
100 le amino acid carriers and to tripeptides or octapeptides containing tyrosine or histidine as central
101 nexpected functional properties of 1 and the octapeptide cyclo(3-14)H-Cys-Phe-Phe-Trp(8)-Lys-Thr-Phe-
102 the PG monomer revealed that the ramoplanin octapeptide D-Hpg-D-Orn-D-alloThr-Hpg-D-Hpg-alloThr-Phe-
103 MSO-d6, 300 K) and molecular modeling of the octapeptide D-Phe1-Cys2-Phe3-D-Trp4-Lys5-Thr6-Cys7+ ++-T
106 hapten-modified peptides, the immunodominant octapeptide derived from vesicular stomatitis virus nucl
107 TyrBm oxidation of three tyrosine-containing octapeptides derived from glycinin was analyzed by oxyge
110 helix with the additional involvement of the octapeptide domain and its N-terminal flanking amino aci
111 riant, c.547G>A (p.Gly183Ser), affecting the octapeptide domain of PAX5 that was found to segregate w
116 the contractile response to cholecystokinin octapeptide for up to 96 hours after endotoxin administr
117 N15 TCR [1-4] and its peptide-MHC ligand, an octapeptide fragment representing amino acids 52-59 of t
119 xyphenylalanine, is a potently antimicrobial octapeptide from the blood cells of the solitary tunicat
125 a)-methylated aminoglycine (Agl) scan of the octapeptide H-c[Cys(3)-Phe(6)-Phe(7)-dTrp(8)-Lys(9)-Thr(
126 pseudobactins from P. fluorescens A225, the octapeptide has the sequence Chr-Ser(1)-Ala-AcOHOrn-Gly-
127 the lack of the canonical B-chain C-terminal octapeptide, has similar receptor binding affinity to hu
128 A (D-ala(1)-peptide T-amide, a gp120-derived octapeptide homologous to VIP) prevent neuronal cell dea
130 +) release in response to angiotensin II, an octapeptide hormone that promotes cardiac hypertrophy.
132 nous application of sulfated cholecystokinin octapeptide in a reversible and concentration-dependent
134 the contractile response to cholecystokinin octapeptide in gallbladder strips 4 hours after endotoxi
135 support has been used to synthesize tri- to octapeptides in 28 to 97% yields using only 1.2 equiv of
138 rdiopulmonary resuscitation, cholecystokinin octapeptide induced mild hypothermia, attenuated postres
139 -free liposomes for 4 hours, cholecystokinin octapeptide-induced contraction, membrane cholesterol co
142 ce express a prion protein (PrP) with a nine-octapeptide insertion associated with a human familial p
143 sed Tg(PG14) mice, which express PrP with an octapeptide insertion associated with an inherited prion
144 olog of a mutant human PrP containing a nine octapeptide insertion associated with prion dementia.
145 ansgenic mice express PrP that harbor a nine-octapeptide insertional mutation homologous to one descr
146 port the development of mini-Ins-a human des-octapeptide insulin analog-as a structurally minimal, fu
147 monstrate that the incorporation of the FLAG octapeptide into the HI loop does not ablate fiber trime
148 d PA225-I, II), the serine(1) residue of the octapeptide is attached to the carboxylic acid group on
149 that, for a range of solid tumours, a cyclic octapeptide labelled with a near-infrared dye selectivel
150 des forming well-defined nanostructures, the octapeptide Lanreotide has been considered one of the be
151 H3K79 methyltransferase, interacts with the octapeptide/leucine zipper domain of AF10, and this regi
152 substrate specificity using tetrapeptide and octapeptide libraries in a positional scanning format, e
154 ently revised receptor-bound model for CCK-B octapeptide ligands and are in good agreement with the D
155 eptin docking site was mapped to a divergent octapeptide loop in the AGR2 superfamily between amino a
156 r the suggestion that the Cys-110 to Cys-117 octapeptide loop of human AGRP mimics the conformation o
157 rangement of the disulfide bonds predicts an octapeptide loop, and the chemical properties of four re
158 rotein that contains the naturally processed octapeptide LTFNYRNL (LYL8) presented by the Kb MHC mole
161 e of the pathogen Shigella flexneri Y and an octapeptide (Met-Asp-Trp-Asn-Met-His-Ala-Ala), a functio
164 ng PEPSCAN each mAb reacted with a number of octapeptides, most of which were derived from within the
166 Here, we rationally designed a high binding octapeptide, N-KSGKSKPR-C peptide for AFB1 detection, by
167 and vesicular stomatitis virus nucleoprotein octapeptide N52-59 relevant for the lymphocytic choriome
168 itioning of ions into a self-assembled (D,L)-octapeptide nanotube, cyclo[-(L-Ala-D-Ala)(4)-], are pre
174 9), and its interactions with the C-terminal octapeptide of cholecystokinin (CCK-8) have been determi
175 his study was undertaken to test whether the octapeptide of cholecystokinin (regular CCK-8) and pharm
176 The bimolecular complex of the C-terminal octapeptide of cholecystokinin, CCK-8, with the N-termin
179 EBNA-1 and the maximally overlapping unique octapeptides of EBNA-1 were tested by modified ELISAs.
180 receptor C-terminal sequence, as well as for octapeptides of eight other putative partner proteins of
181 uated the binding of lupus autoantibodies to octapeptides of nuclear ribonucleoprotein (nRNP) A, iden
182 sera by solid-phase scanning of overlapping octapeptides of variable domains (VDs) of the major oute
183 predominant that was converted to the final octapeptide only in presence of the appropriate MHC I mo
186 cted in mice with homozygous deletion of the octapeptide or partial homeodomain, both sequences were
187 monitoring the generation of an OVA-derived octapeptide, OVA257-264 (SL8), and its C-terminally exte
188 portion a nuclear localization signal and an octapeptide (PPPRMPPP) with similarity to a major B cell
189 p beta C8Ala, AspCD2Ala) mutant bound to the octapeptide PQpYEEIPI (where pY indicates a phosphotyros
190 sion in tumour-associated stromal cells, the octapeptide preferentially binds to the invasive edges o
191 molecules that mimic this epsilonPKC agonist octapeptide provide a powerful therapeutic approach to p
192 we describe an epsilonPKC-selective agonist octapeptide, psiepsilon receptor for activated C-kinase
193 ensus epitope via in vitro evolution yielded octapeptides QPEQAFPE and PFPEQxFP that identified omega
194 d in protegrins and tachyplesins whereas the octapeptide R8 (RLYRKVYG) consists of an R4 and a degene
196 otoxic hybrid analogs of somatostatin (SST), octapeptides RC-160 (D-Phe-Cys-Tyr-D-Trp- Lys-Val-Cys-Tr
197 is experiments, confirmed the presence of an octapeptide receptor-binding domain toward the amino ter
198 d-type affinity for sulfated cholecystokinin octapeptide, receptors with increasing amino-terminal co
200 rion disease caused by a prion protein (PrP) octapeptide repeat insertion mutation originates from so
201 tations P102L, D178N, E200K and 2-, 4- and 6-octapeptide repeat insertions) and show that the glycofo
203 a bacterial gene that encodes a glycine-rich octapeptide repeat protein with distinct variants capabl
204 to bind to the protein in a highly conserved octapeptide repeat region (sequence PHGGGWGQ) near the N
207 nic strength, confirming that the N-terminal octapeptide repeat region of PrPSc is not required for b
209 ing sites are localized predominantly in the octapeptide repeat region, whereas sites that bind both
210 lly, we explored somatic mosaicism of PRNP's octapeptide repeat region, which is a hypothetical cause
213 ecules expressing 7, 9, and 11 copies of the octapeptide repeat sequence showed altered cell surface
214 rion-related peptides differing in number of octapeptide repeat units (PHGGGWGQ), (PHGGGWGQ)(2), and
215 (IPD) include an insertion of six additional octapeptide repeats (6-OPRI) and a missense mutation (P1
216 on-protein-mediated zinc influx requires the octapeptide repeats and amino-terminal polybasic region
218 und that only a mutant containing nine extra octapeptide repeats failed to suppress Bax-induced cell
220 res the presence of at least one of the five octapeptide repeats normally present in the N-terminal h
221 oma cells, hamster PrP-sen with 5, 9, and 11 octapeptide repeats were expressed normally on the cell
222 e, hamster PrP molecules with greater than 7 octapeptide repeats were more aggregated and more protea
223 s a mutant prion protein (PrP) containing 14 octapeptide repeats whose human homologue is associated
224 express a pathogenic mutant with nine extra octapeptide repeats, also binds more strongly to GAG tha
227 tion of patients from the UK with four extra octapeptide repeats, which suggest that the risk of clin
237 ngly, the deduced BGAF sequence contained an octapeptide sequence (G(P/R)WGGSGG) repeated twice.
239 use treatment of patients with peptide T (an octapeptide sequence found in the human immunodeficiency
241 two-residue ay C(12) turn segment in a model octapeptide sequence Leu-Phe-Val-Aib-Xxx-Leu-Phe-Val (wh
243 ) contains four copies of a highly conserved octapeptide sequence, PHGGGWGQ, that is flanked by two p
244 different amino acids in a highly-conserved octapeptide sequence, Z8, located within the region remo
246 confers a conjugative mating response to an octapeptide sex pheromone (cAD1) secreted by plasmid-fre
247 a mating response induced by exposure to an octapeptide sex pheromone, cAD1, secreted by plasmid-fre
249 r a series of tripeptides and for two larger octapeptides, showing that the diagnostic phosphate OH s
251 65), fused to a polypeptide that contains an octapeptide (SIYRYYGL) agonist for a particular T cell r
252 d on the observation that SSTR1 can bind the octapeptide SMS-201-995 with reasonable affinity after a
253 i-PMScl positive sera did not react with any octapeptide spanning the major epitope area (aa 207-246)
254 on of a mass-labeled leucine monomer from an octapeptide spiked standard was employed as a measure of
255 of 2-pyrrolinodoxorubicin (AN-201) linked to octapeptide SRIF carrier RC-121, may overcome this resis
256 ral CCK receptor agonist CCK8S (sulfated CCK octapeptide) strongly depolarized the neurons, and this
257 CoA analogue [S-(2-oxo)pentadecylCoA] and an octapeptide substrate (GLYASKLA) to 2.5 A resolution.
259 those functional groups in the high-affinity octapeptide substrate GLYASKLS-NH2 1a necessary for tigh
260 nhibitors of Candida NMT with respect to the octapeptide substrate GNAASARR-NH2 with Ki(app) = 30 and
262 anti-apoptotic effect of MN10021 and derived octapeptides suggesting that their potent vasoprotective
265 we report the synthesis of Bzim-CP, a cyclic octapeptide that contains a benzimidazole functionality
266 with a paired-type homeobox, as well as the octapeptide that is found in many paired-type homeobox g
267 Argyrins are a family of naturally produced octapeptides that display promising antimicrobial activi
269 s, respectively; for three isomeric phospho-octapeptides, the accuracy becomes 4.1% and 11% for 17 m
270 s proof-of-concept applications, we used the octapeptide to detect tumour xenografts and metastatic l
271 cently we demonstrated that the fusion of an octapeptide to the C-terminus of a cysteine-free mutant
272 significantly better in the cholecystokinin octapeptide-treated animals when compared to the control
275 ommon ligand, the vesicular stomatitis virus octapeptide (VSV8) bound to H-2Kb, were studied to defin
277 heat capacity change (DeltaCp) for the 5HT2c octapeptide was determined to be -94 cal/mol, and a calc
279 ximal contraction induced by cholecystokinin octapeptide was significantly less in gallbladders with
280 -to-left synthetic approach to this bicyclic octapeptide was unsuccessful due to an inability to elab
281 ) and several lanthionine hexa-, hepta-, and octapeptides was carried out by using the method of cycl
282 nodoxorubicin (AN-201) linked to SST carrier octapeptide, was investigated in human renal cell carcin
283 sed approach and starting from a linear MLL1 octapeptide, we have designed a class of potent macrocyc
284 te formation induced by the full agonist CCK octapeptide were comparable for the wild-type receptor a
285 n response to 30 and 60 pmol cholecystokinin octapeptide were significantly lower in STZ-D rats compa
293 PLC) analysis of a tryptic digest yielded an octapeptide within the insert of PDE3A ((K)T(806)YNVTDDK