ライフサイエンスコーパス: octopamine

1 orm appetitive memory, even in flies lacking octopamine.

2 ear to mediate the wake-promoting effects of octopamine.

3 hort-term appetitive memory is reinforced by octopamine.

4 the beta-hydroxylation of tyramine to yield octopamine.

5 t dopamine is a stronger arousal signal than octopamine.

6 e neurons respond to in vitro application of octopamine.

7 ype levels by pharmacological treatment with octopamine.

8 esicular storage of dopamine, serotonin, and octopamine.

9 insensitive to the wake-promoting effects of octopamine.

10 other that detects another neurotransmitter, octopamine.

11 ne beta-hydroxylase to convert tyramine into octopamine.

12 0.5-1.5 microm), a subset of which contained octopamine.

13 ramine, beta-phenethylamine, tryptamine, and octopamine.

14 luminescence induced by the neurotransmitter octopamine.

15 ents, and from more nerves per segment, than octopamine.

16 ositive OC interneurons and its followers is octopamine.

17 o increase body temperature by administering octopamine.

18 mone that incorporates the neurotransmitter, octopamine.

19 ne, GABA, glutamate, serotonin, dopamine and octopamine.

20 e neurotransmitters dopamine, serotonin, and octopamine.

21 e effects are mimicked by the neuromodulator octopamine.

22 d from succinylation of the neurotransmitter octopamine.

23 ities as the less commonly reported feruloyl octopamine (1.2-5.2), 5-O-feruloyl quinic acid (0.1-7.5)

24 N-(11)C-guanyl-(-)-meta-octopamine ((11)C-GMO) has a much slower NET transport r

25 than reported in previous studies regarding octopamine (4.5 %) and glutamate release (31 %).

26 Bath application of octopamine, 5-HT, and dopamine at concentrations of 10(-

27 ocal axon modulation with the biogenic amine octopamine, abolished signal integration at the primary

28 We conclude that tyramine and octopamine act as neurotransmitters/modulators in distin

29 rate biogenic amines structurally related to octopamine acted as superagonists at the DmOctR but part

30 s define the cellular and molecular basis of octopamine action and suggest that the PI is a sleep:wak

31 Similarly, peripheral octopamine action on motoneurons has been reported to be

32 Here, we report that octopamine activity through the beta-adrenergic-like rec

33 Octopamine acts rapidly upon the onset of flight to modu

34 Octopamine also affects metabolism in invertebrate speci

35 f Neuron, Watanabe et al. (2017) uncover how octopamine, an invertebrate norepinephrine analog, modul

36 Octopamine and 5-hydroxytryptamine are not active (< 100

37 a mutation in dTdc2 lack neural tyramine and octopamine and are female sterile due to egg retention.

38 ition, they reconcile previous findings with octopamine and dopamine and suggest that reinforcement s

39 This study identifies the cognate actions of octopamine and dopamine signaling as a key neural mechan

40 ulatory circuits, especially those involving octopamine and dopamine.

41 changes in synaptic structure in response to octopamine and for starvation-induced increase in locomo

42 Octopamine and glutamate treatments increased the likeli

43 are wake-promoting and respond to dopamine, octopamine and light.

44 on of particular concentrations of the drugs octopamine and nicotine, but due to high environmental v

45 , Drosophila melanogaster, and Danio rerio - octopamine and norepinephrine play an essential role in

46 ing conditions also influenced antennal lobe octopamine and serotonin, neuromodulators involved in st

47 nd held at a potential sufficient to oxidize octopamine and the terminal stimulated by blue light.

48 dc expression contribute to a model in which octopamine and tyramine have distinct and separable neur

49 The two biogenic amines octopamine and tyramine have recently been shown to modu

50 Given various potential roles of octopamine and tyramine in the larval brain, such as loc

51 By using mutants having altered octopamine and tyramine levels and by genetic interferen

52 Therefore, octopamine and tyramine provide global but distinctly di

53 ng crowding and isolation, the activities of octopamine and tyramine signalings were respectively cor

54 Tbetah(nM18) mutants, with altered levels of octopamine and tyramine, have a locomotion deficit.

55 s well as an increase in cAMP in response to octopamine, and genetic manipulation of their electrical

56 ransport activity; norepinephrine, tyramine, octopamine, and histamine also have high affinity for th

57 invertebrate counterpart of norepinephrine, octopamine, and its biological precursor and functional

58 mechanism involving the VEGF2-like receptor, octopamine, and its receptor.

59 we have defined the roles of tyramine (TA), octopamine, and neuropeptides in the inhibition of avers

60 lso have lower levels of hemolymph dopamine, octopamine, and serotonin.

61 selective alpha-adrenergic receptor agonist, octopamine, and the specific alpha(1) agonist, phenyleph

62 Octopamine- and tyramine immunostaining in the central c

63 ing machinery, provides direct evidence that octopamine- and tyramine-based neuromodulation can be me

64 ned the patterns seen with the tyramine- and octopamine antisera.

65 In contrast, octopamine appears to inhibit 5-HT stimulation by activa

66 sed cAMP and intracellular Ca2+ levels after octopamine application.

67 tants unable to synthesize the catecholamine octopamine are also impaired in their ability to develop

68 mine, beta-phenylethylamine, tryptamine, and octopamine are biogenic amines present in trace levels i

69 e neurotransmitters serotonin, dopamine, and octopamine are converted to a large extent into the corr

70 nattractive flowers, however, is mediated by octopamine-associated modulation of antennal-lobe neuron

71 Facilitation is mimicked by bath applied octopamine at 5 microM.

72 nism, activation of Octss2R autoreceptors by octopamine at octopaminergic neurons initiated a cAMP-de

73 In-depth analysis of octopamine auditory function shows that it affects the m

74 re, we report the presence of an alternative octopamine autoreceptor, Octss1R, with antagonistic func

75 e-feedback mechanism that required Octbeta2R octopamine autoreceptors.

76 ein 90, and SBV-infected bees expressed more octopamine beta-2 receptor (Obeta-2R).

77 n intact neuronal circuit, with dopamine and octopamine bidirectionally influencing the generation of

78 Octopamine binds to receptors located on various cell ty

79 Mutations in the octopamine biosynthesis pathway produced a phenotype of

80 Octopamine biosynthesis requires tyrosine decarboxylase

81 e absence of TBH protein and blockage of the octopamine biosynthesis.

82 , the enzyme that catalyzes the last step in octopamine biosynthesis.

83 ult locomotion and startle behavior required octopamine, but a complementary role was observed for se

84 y produced tyramine is probably converted to octopamine by the host tyramine beta-hydroxylase enzyme.

85 Additionally, the tyrosine analogue octopamine can replace topoisomerase I derived peptides

86 that mimic those observed during flight, and octopamine cells that project to the optic lobes increas

87 We have examined the role of the octopamine-containing buccal OC interneuron in the ficti

88 rties of synaptic connections from the three octopamine-containing OC interneurons to identified bucc

89 defect in egg laying is associated with the octopamine deficit, because females that have retained e

90 couple of brain neurons modulate a specific octopamine-dependent behavior to adapt female physiology

91 an and that these cells do not control other octopamine-dependent behaviors such as female receptivit

92 rivation was accompanied by an activity- and octopamine-dependent extension of octopaminergic arbors

93 Moreover, octopamine-dependent memory formation requires signallin

94 energic-like OCTbeta2R receptor reveals that octopamine-dependent reinforcement also requires an inte

95 Investigating the biogenesis of these octopamine-derived ascarosides, we found that succinylat

96 The biogenic amine octopamine did not elicit pheromone production in isolat

97 igate the effect of several neuromodulators (octopamine, dopamine, acetylcholine, serotonin and proct

98 ransmitter release by biogenic amines, e.g., octopamine, dopamine, or serotonin.

99 They also block the octopamine-evoked inhibition of B3, N2 and N3 neurons.

100 Octopamine-evoked neuropeptide release also requires end

101 Pharmacological application of octopamine evokes responses in quiescent flies that mimi

102 Octopamine exposure mimics flight effects in one, wherea

103 In the locust, these neurons synthesize octopamine from tyramine stress-dependently.

104 rd-based and punishment-based learning while octopamine function is important only for reward.

105 OCTR-1, a putative octopamine G protein-coupled catecholamine receptor (GPC

106 Additionally, octopamine had direct effects on the STG, including the

107 insects, such as honeybees and fruit flies, octopamine has been shown to be a major stimulator of ad

108 Instead, octopamine has historically been considered to be the si

109 hed in seven steps in 10% overall yield from octopamine hydrochloride (17), N-(Boc)glycine (16), and

110 mine, in contrast, was strikingly similar to octopamine immunolabeling.

111 idence that the neurotransmitter between the octopamine-immunopositive OC interneurons and its follow

112 meres except in abdominal ganglion 5) and 48 octopamine-immunoreactive cell bodies (in brain and thor

113 The pattern of appearance of octopamine-immunoreactive cells is cell type-specific.

114 ods to examine the sequence of appearance of octopamine-immunoreactive neurons during development, an

115 ells appear at about the same time the first octopamine-immunoreactive neurons show staining.

116 ntennal lobes are supplied by at least three octopamine-immunoreactive neurons.

117 discussed with respect to recent studies on octopamine-immunoreactive organization in honey bees and

118 Octopamine-immunoreactive processes from one or more cel

119 In both taxa octopamine-immunoreactive processes invade only the gamm

120 markably similar to the previously described octopamine immunoreactivity in Drosophila.

121 onfocal immunocytochemistry revealed intense octopamine immunoreactivity in the anterior lateral asso

122 In contrast, octopamine immunostaining was present in two bilateral p

123 TBH), the enzyme that converts tyramine into octopamine in aminergic neurons, is increased by food de

124 athy, we uncovered an unprecedented role for octopamine in driving the conversion from toxic to neuro

125 that underlies the wake-promoting effects of octopamine in Drosophila.

126 The role of the biogenic amine octopamine in modulating cholinergic synaptic transmissi

127 tion center, thus confirming the presence of octopamine in neuropil regions containing fSR/BA1 synaps

128 s knowledge gap, we investigated the role of octopamine in olfactory conditioning.

129 e roles of the biogenic amines serotonin and octopamine in regulating locomotion behaviors associated

130 discussed with respect to possible roles of octopamine in sensory integration and association.

131 s and cockroaches and the suggested roles of octopamine in sensory processing, learning, and memory.

132 ut little is known about the distribution of octopamine in the brain.

133 its thus contributing to the many actions of octopamine in the central nervous system.

134 were able to induce hypothermia by depleting octopamine in the flight muscles.

135 It is suggested that these neurons release octopamine in the ventral nerve cord ganglia and, most l

136 g for TBH, the enzyme converting tyramine to octopamine, in contrast, was strikingly similar to octop

137 lyzes the synthesis of the neurotransmitter, octopamine, in insects.

138 Octopamine, in turn, targets the OCTR-1 octopamine recep

139 Octopamine increases the cycle frequency of the pyloric

140 When applied only to the stn-son junction, octopamine induced action potentials in the axons of the

141 (10(-6) M) had no significant effect on the octopamine-induced decrease in ACh responses.

142 uced by postsynaptic receptor block mirrored octopamine-induced Unc13 recruitment and required presyn

143 out the identity of the neurons that receive octopamine input and how they mediate octopamine-regulat

144 Octopamine is a major monoamine in invertebrates and aff

145 Octopamine is a neuroactive monoamine that functions as

146 Octopamine is a neuromodulator that mediates diverse phy

147 Although we showed that the neuromodulator octopamine is implicated, the identity of the involved n

148 he first evidence that endogenous release of octopamine is involved in state-dependent modulation of

149 Octopamine is likely to be an important neuroactive mole

150 ate protein source in mated females and that octopamine is specifically required to mediate homeostat

151 ramine are the preferred substrates, whereas octopamine is transported less efficiently, and serotoni

152 re we show that a Drosophila biogenic amine, octopamine, is a potent wake-promoting signal.

153 ve behavioral imaging, we show that 5-HT and octopamine jointly influence locomotor activity and quie

154 systemic injection with the receptor ligand octopamine leads to increased cAMP levels in this specif

155 eptor whose activation by its natural ligand octopamine leads to rapid and transient increases in cAM

156 T beta h-null flies are octopamine-less but survive to adulthood.

157 ensitivity to CO(2) in flight via changes in octopamine levels, along with Ir64a, quickly switches th

158 in as well as many midline perikarya provide octopamine-like immunoreactive processes to circumscribe

159 e brain as well as midline perikarya provide octopamine-like immunoreactive processes to the optic lo

160 clonal antibody to study the distribution of octopamine-like immunoreactivity in the brain of the haw

161 of octopamine, the receptor responsible for octopamine-mediated modulation could not be characterize

162 od deprivation increases locomotor speed via octopamine-mediated structural plasticity of neuromuscul

163 These results suggest that octopamine mediates consolidation of a component of olfa

164 Dopamine and octopamine modulated intracellular cAMP in spatially dis

165 y be an important circuit mechanism by which octopamine modulates behavior.

166 uding L-3,4-dihydroxyphenylalanine, N-acetyl octopamine, N-acetyldopamine, naTA, N-acetylserotonin, O

167 We further show that octopamine neurons are required for sustained behavioral

168 toinhibition is seen in spontaneously active octopamine neurons but is absent from spontaneously acti

169 Furthermore, we found that octopamine neurons contact Crz neurons in the subesophag

170 The first octopamine neurons express their transmitter phenotype a

171 We investigated the role of octopamine neurons in the flight-dependent modulation ob

172 ng flight, and blocking synaptic output from octopamine neurons inverts the valence assigned to CO(2)

173 In addition, octopamine neurons regulated the expansion of excitatory

174 ll five octopamine receptors express in Tdc2/octopamine neurons to varying degrees.

175 genetic tools to manipulate the activity of octopamine neurons, we find that they are both necessary

176 ity seems plausible: the three pairs of claw octopamine neurosecretory cells show immunostaining as a

177 Use of immunostaining for the octopamine neurotransmitter synthesis enzyme Tdc2, along

178 There is ample evidence linking octopamine (OA) and tyramine (TA) to several neurophysio

179 t that the biogenic amines tyramine (TA) and octopamine (OA) in Drosophila melanogaster females play

180 Here, we show a role of the neuromodulator octopamine (OA) in the female postmating response.

181 In Caenorhabditis elegans, tyramine (TA) and octopamine (OA) inhibit aversive responses to 100%, but

182 with a reduction in dMBD-R2 specifically in octopamine (OA) neurons exhibit courtship toward diverge

183 pathway requiring an alpha2A-adrenergic-like octopamine (OA) receptor, OCTR-1, and a 5-HT1A-like sero

184 Ovulation requires octopamine (OA) signaling from the central nervous syste

185 Octopamine (OA), a biogenic amine similar to norepinephr

186 rtex of follicle cells upon stimulation with octopamine (OA), a monoamine critical for Drosophila ovu

187 r biogenic amines, such as dopamine (DA) and octopamine (OA), have yet to be completed.

188 the response of tubules to the related amine octopamine (OA), indicating that OA can activate TAR2.

189 clude dopamine, epinephrine, norepinephrine, octopamine (OA), L-3, 4-dihydroxyphenylalanine, tyramine

190 Octopamine (OA), the insect homolog of NE, is known to p

191 Octopamine (OA), the invertebrate counterpart of norepin

192 nalytes, such as N-acetyltyramine (naTA) and octopamine (OA).

193 the Oamb gene, which encodes a receptor for octopamine (OA, the invertebrate homologue of norepineph

194 arning, whereas the octopamine-Octbeta1R and octopamine-OAMB pathways jointly facilitate appetitive,

195 Thus, the invertebrate-specific octopamine-OARalpha and tyramine-TAR signalings respecti

196 noamines dopamine (DA), serotonin (5HT), and octopamine (Oct) can each sculpt a unique motor pattern

197 sion assays indicate that the neuromodulator octopamine (OCT) is necessary for Drosophila males to co

198 Furthermore, we show that the octopamine-Octbeta1R and dopamine-dDA1 signals together

199 versive and appetitive learning, whereas the octopamine-Octbeta1R and octopamine-OAMB pathways jointl

200 Here, we demonstrate that the octopamine-Octbeta1R-cAMP pathway processes both aversiv

201 ially by insulin, suggesting that effects of octopamine on metabolism are independent of its effects

202 , we investigated its role in the effects of octopamine on sleep.

203 Effects of octopamine on sleep:wake are mediated by the cAMP-depend

204 if insulin signaling mediates the effects of octopamine on sleep:wake behavior, we assayed flies in w

205 These results demonstrate the dual action of octopamine on synaptic growth and behavioral plasticity,

206 ) has a hyperpolarizing agonist effect (like octopamine) on these neurons and also blocks their chemi

207 aggression has shown that the biogenic amine octopamine plays a role in the modulation of aggressive

208 Octopamine plays central roles in various learning types

209 To test more specifically what role octopamine plays in the antennal lobe, we used two treat

210 rward pairing of neuronal depolarization and octopamine produced a subadditive effect on cAMP.

211 Octopamine, produced by the RIC neurons, acts via SER-3

212 Local perfusion of 10(-4) M octopamine produces the same inhibitory membrane respons

213 Moreover, electrical silencing of octopamine-producing cells decreased wakefulness, wherea

214 e findings may be relevant to the control of octopamine production in insect cells.

215 stablished that, in Drosophila, dopamine and octopamine promote increased arousal.

216 CO(2) repulsion in well-fed animals, whereas octopamine promotes CO(2) attraction in starved animals.

217 Octopamine promotes wakefulness in the fly by acting thr

218 te-gated chloride channel (avermectins), the octopamine receptor (amitraz metabolite), and the calciu

219 hat dopaminergic neurons expressing the OAMB octopamine receptor [6] specifically convey the short-te

220 RNA interference verified that octopamine receptor alpha (OARalpha) signaling in gregar

221 mushroom bodies (OAMB), was identified as an octopamine receptor because human and Drosophila cell li

222 Furthermore, octopamine receptor disruption, and FAC-mediated oxidati

223 to mianserin/dsRNA treatment did not reverse octopamine receptor disruption-mediated inhibitory respo

224 l lobe, we used two treatments to disrupt an octopamine receptor from Apis mellifera brain (AmOAR) fu

225 equency of a mutation in the beta-adrenergic octopamine receptor gene (RmbetaAOR).

226 One new receptor, octopamine receptor in mushroom bodies (OAMB), was ident

227 promote ovulatory competency by upregulating octopamine receptor in mushroom body (OAMB), matrix meta

228 To identify an octopamine receptor mediating this function in Drosophil

229 Moreover, an octopamine receptor mRNA is selectively enriched in l-LN

230 aging) induced by starvation was elevated in octopamine receptor mutants, despite their high propensi

231 The octopamine receptor OAMB has two isoforms (OAMB-K3 and O

232 Octopamine, in turn, targets the OCTR-1 octopamine receptor on ASH nociceptive neurons to modula

233 d expression of a Galphas-coupled Drosophila octopamine receptor selectively in mouse hippocampal exc

234 on the heterologous expression of an Aplysia octopamine receptor, a G-protein-coupled receptor whose

235 The alpha-like octopamine receptors (OctR) are believed to be the evolu

236 ective motion-detecting neurons that express octopamine receptors elicits visual valence reversal in

237 ditional Tdc2-LexA driver, revealed all five octopamine receptors express in Tdc2/octopamine neurons

238 previously identified one of the Drosophila octopamine receptors named OAMB that produces increases

239 euronal expression was observed for all five octopamine receptors, yet distinct differences among the

240 n-Gal4 lines for each of the five Drosophila octopamine receptors.

241 ns, the biogenic amines serotonin (5-HT) and octopamine regulate a number of food-related behaviors.

242 eceive octopamine input and how they mediate octopamine-regulated behaviors.

243 The biogenic amine octopamine regulates critical physiological processes du

244 Furthermore, after consolidation, octopamine release becomes essential for recall, which s

245 Octopamine release by one such pathway in the honeybee a

246 a parsimonious model in which odor-activated octopamine release excites the motion detection pathway

247 anipulation in Type II varicosities to study octopamine release in Drosophila.

248 Tyramine and octopamine released from neurons expressing tyrosine dec

249 We observe 22700+/-4200 molecules of octopamine released per vesicle.

250 lation (-89.0 mV, S.E.M.=14.1, n=10) and the octopamine response of the B3 neurons (-84.7 mV, S.E.M.=

251 ct mechanisms: light-mediated suppression of octopamine responses was regulated by the circadian cloc

252 Although other Drosophila mutants that lack octopamine retain eggs completely within the ovaries, dT

253 A serum raised against octopamine reveals in cockroaches and honey bees structu

254 A serum raised against conjugated octopamine reveals structurally comparable systems of pe

255 These results demonstrate that serotonin and octopamine reversibly modulate the activity of the ASHs,

256 Octopamine's effects on cycle frequency require an under

257 AMB receptor is a key molecule mediating the octopamine's signal for appetitive olfactory learning an

258 MB in the mushroom body neurons mediates the octopamine's signal for appetitive olfactory learning.

259 sion to attraction such that animals lacking octopamine show a delayed shift to attraction.

260 Part of the octopamine signal requires the alpha-adrenergic-like OAM

261 icate that sweet taste engages a distributed octopamine signal that reinforces memory through discret

262 es are decreased in mutants with compromised octopamine signaling and elevated in flies with increase

263 otein kinase A (PKA) is a putative target of octopamine signaling and is also implicated in Drosophil

264 In this study, we present octopamine signaling as a neurochemical prerequisite for

265 Moreover, flies with increased octopamine signaling do not suppress sleep in response t

266 he oocytes of Caenorhabditis mutants lacking octopamine signaling fail to remain quiescent, but conti

267 We then blocked octopamine signaling in random areas of the fly brain an

268 Finally, octopamine signaling in the service of thermogenesis mig

269 to assume food-appropriate behavior, whereas octopamine signaling is required for animals to assume f

270 indispensable contributions of dopamine and octopamine signaling to aversive and appetitive learning

271 Genetic and pharmacologic approaches suggest octopamine signaling transmits changes in aggression upo

272 he starvation response of flies with altered octopamine signaling.

273 r dopamine overturns the previous model that octopamine signalled reward and dopamine punishment.

274 uires bacterially produced tyramine and host octopamine signalling.

275 Among them, octopamine stands out as an auditory modulator during sw

276 Serotonin, dopamine, and octopamine stimulate locomotion and grooming, showing di

277 gs initiate egg laying when transferred onto octopamine-supplemented food.

278 ng several mechanisms, notably through GABA, octopamine synapses, and the inhibition of acetylcholine

279 BH likely being the rate-limiting enzyme for octopamine synthesis in a small subpopulation of TDC-con

280 ed in the absence of extracellular Ca(2+) by octopamine, the arthropod homolog to norepinephrine.

281 Octopamine, the invertebrate analog of norepinephrine, i

282 We investigated the role of octopamine, the invertebrate counterpart of adrenaline a

283 Octopamine, the invertebrate homolog of mammalian adrena

284 and tolazoline both mimicked the actions of octopamine, the receptor responsible for octopamine-medi

285 Application of tyramine or octopamine to live preparations silenced dopaminergic ne

286 Octopamine triggers an increase in intracellular calcium

287 neurons immunoreactive with antisera against octopamine, tyramine, and the enzymes required for their

288 es to stimulate Ca(2+) increases through the octopamine/tyramine receptor (Oct-TyrR) and the transien

289 The expression of a cloned Drosophila octopamine/tyramine receptor (OctyR99AB) is described in

290 maps to 99B3-5, close to the position of the octopamine/tyramine receptor gene at 99A10-B1, suggestin

291 ractive behaviors, we have cloned a putative octopamine/tyramine receptor.

292 ates ecdysteroid biosynthesis in response to octopamine, uncovering a regulatory neuroendocrine syste

293 ify the roles of tyramine and its metabolite octopamine, we have cloned two TDC genes from Drosophila

294 octbeta1r brain exhibit blunted responses to octopamine when cAMP levels are monitored through the cA

295 abolomic profiling data identified a QTL for octopamine, which co-localised with the QTL for liver hi

296 ted in vivo in mice chronically treated with octopamine, which exhibited reduction in liver histopath

297 human primates with [11C]1e, N-[11C]guanyl-m-octopamine, which has a slow NET transport rate, showed

298 tion of Type II boutons evokes exocytosis of octopamine, which is detected through oxidization at the

299 Surprisingly, the application of octopamine, which is released during flight, reverses th

300 before and after mating: the biogenic amine octopamine, which regulates ovulation rate in Drosophila