ライフサイエンスコーパス: ocular surface

1 a ST-AMG for reconstruction or repair of the ocular surface.

2 um is altered, with a negative impact on the ocular surface.

3 r characterized by an abnormal tear film and ocular surface.

4 y innervated to sustain the integrity of the ocular surface.

5 nd infiltration of inflammatory cells to the ocular surface.

6 tory factors in promoting homeostasis at the ocular surface.

7 o produce enough tears to maintain a healthy ocular surface.

8 ree-dimensional (3D) coculture model for the ocular surface.

9 bular organ that protects and lubricates the ocular surface.

10 in 30.9% (51/165 eyes) to maintain a stable ocular surface.

11 maintenance of the epithelial barrier at the ocular surface.

12 a major prosecretory chloride channel at the ocular surface.

13 s occurring by instilling an allergen on the ocular surface.

14 eptor (NK1R), are reported to present on the ocular surface.

15 ich play an important role in protecting the ocular surface.

16 to rapid clearance (low residence time) from ocular surface.

17 secretion of the protective GC mucins on the ocular surface.

18 etion, and the loss of dendriform DCs at the ocular surface.

19 CFTR) is a major prosecretory channel at the ocular surface.

20 microbial commensals and inflammation on the ocular surface.

21 have applicability to other diseases of the ocular surface.

22 intenance of the integrity and health of the ocular surface.

23 of mast cells to allograft rejection at the ocular surface.

24 cells in promoting allosensitization at the ocular surface.

25 otal role in sustaining the integrity of the ocular surface.

26 h the secretion of factors directly onto the ocular surface.

27 lated environmental homeostasis of the human ocular surface.

28 al ischemia identified on OCTA images of the ocular surface.

29 ere bilateral corneal blindness but with wet ocular surfaces.

30 order to improve drug bioavailability on the ocular surfaces.

31 atients in category 2 had significantly more ocular surface abnormalities than patients in category 1

32 ncluded select patients with typically large ocular surface abnormalities that required reconstructio

33 aturation of antigen-presenting cells at the ocular surface after exposure to desiccating stress.

34 capacity of licensed vaccines to protect the ocular surface against infection is limited.

35 lows successful and sustained restoration of ocular surface anatomy with functional improvement, in e

36 while 15.2% (25/165) maintained an improved ocular surface and 12.1% (20/165) developed total surfac

37 um and modeling various pathologies of human ocular surface and adnexa.

38 eatment period was able to restore a healthy ocular surface and corneal barrier function with compara

39 Mild ocular surface and corneal disease may be treated effect

40 rocedure has a less pronounced impact on the ocular surface and corneal innervation compared with LAS

41 n; however, these medications may affect the ocular surface and elicit ocular discomfort when preserv

42 Initial correlation between OSA and ocular surface and eyelid markers was calculated through

43 cuity, dry eye severity, and scarring of the ocular surface and eyelids were assessed after follow-up

44 resident commensal microbiome exists on the ocular surface and identify the cellular mechanisms unde

45 duction/cleavage of CX3CL1 may contribute to ocular surface and LG inflammation in SS.

46 tein ablation on the physiology of the mouse ocular surface and Meibomian glands (MGs).

47 FPR2 receptor to maintain homeostasis of the ocular surface and regulate histamine responses and coul

48 rm and clear thin layer that conforms to the ocular surface and resists clearance from blinking, incr

49 olution at 3 weeks, epithelialization of the ocular surface and symblepharon.

50 Severity of ocular surface and systemic disease was graded.

51 complex 3D model as a recapitulation of the ocular surface and tear film system, which can be furthe

52 multifactorial disease of the interpalpebral ocular surface and tear film that leads to discomfort, f

53 ts, one of the peptides was noncytotoxic for ocular surfaces and had comparable antimicrobial efficac

54 Lubricant ointment use, a compromised ocular surface, and bandage contact lens use are associa

55 cant ointment use, presence of a compromised ocular surface, and bandage contact lens use were associ

56 requent blinking limit drug retention on the ocular surface, and gelling drops typically form clumps

57 antity of corneal astigmatism, health of the ocular surface, and other ocular comorbidities.

58 Our findings help explain some of the ocular surface anomalies seen in children with EB.

59 al povidone-iodine (PI) is widely used as an ocular surface antiseptic for intravitreal injections (I

60 Attainment and maintenance of a stable ocular surface, as assessed by change in the ocular surf

61 arly inducible gene 1, also increased at the ocular surface at both the protein and gene levels.

62 7 cells are critical effectors mediating the ocular surface autoimmunity in dry eye disease (DED).

63 clearly demonstrate that Th17 cells mediate ocular surface autoimmunity through both IL-17A and IFN-

64 teolytic cleavage may contribute to impaired ocular surface barrier function.

65 portance of formulations that conform to the ocular surface before viscosity enhancement for increase

66 ificant differences in miR expression at the ocular surface between pSS patients and healthy controls

67 and vision restoration in unilateral chronic ocular surface burns.

68 port the safety of predatory bacteria on the ocular surface, but future studies are warranted regardi

69 ntive and measurable impacts not only on the ocular surface, but on quality of life and visual functi

70 treatment for periocular cancers and 2% for ocular surface cancers.

71 ttle is known about the toxicity of SiNPs on ocular surface cells such as human corneal epithelial ce

72 d overproduced Th2 cytokine were observed in ocular surface, cervical lymph nodes and isolated CD4(+)

73 eal surface sensitivity often with secondary ocular surface changes.

74 We compared patient pain scores, ocular surface characteristics, and antimicrobial effica

75 sity enhancement for increased and prolonged ocular surface contact and drug absorption.

76 On ocular surface, corneal epithelial stem cells (SC) resid

77 C function resulted in MG disease and severe ocular surface damage that phenocopied aspects of human

78 inflammatory activity rapidly, triggering an ocular surface deterioration.

79 Povidone-iodine demonstrated greater ocular surface discomfort and corneal epitheliopathy com

80 eusis in situ (2 eyes), and undifferentiated ocular surface disease (4 eyes).

81 , yeasts were the predominant isolates, with ocular surface disease (OSD) being the leading risk fact

82 The purpose of our study was to compare Ocular Surface Disease (OSD) signs and symptoms of Taflu

83 ing body of research that links androgens to ocular surface disease and DED.

84 Ocular surface disease and its complications were associ

85 Rapid blinking is associated with worse ocular surface disease and tear stability.

86 es, such as Meckel syndrome, present several ocular surface disease conditions of unclear pathogenesi

87 tative markers of eyelid laxity or secondary ocular surface disease in a sleep clinic population.

88 trols, at baseline, included mean scores for Ocular Surface Disease Index (31.7 vs 4.1, P < 0.0001),

89 ion of patients by DED parameters including, Ocular Surface Disease Index (OSDI) (<=13, >13) and Schi

90 ation including symptom assessment using the Ocular Surface Disease Index (OSDI) and corneal fluoresc

91 al microscopy (IVCM) and were surveyed using Ocular Surface Disease Index (OSDI) and Glaucoma Symptom

92 LSCM, IC, and the ocular surface disease index (OSDI) and National Eye Ins

93 ptoms of ocular GVHD were assessed using the Ocular Surface Disease Index (OSDI) and Symptom Assessme

94 Ocular Surface Disease Index (OSDI) questionnaire scores

95 An interviewer-assisted Ocular Surface Disease Index (OSDI) questionnaire was us

96 mic assessment including a detailed history, Ocular Surface Disease Index (OSDI) questionnaire, and o

97 Patient symptoms were assessed using the Ocular Surface Disease Index (OSDI) questionnaire.

98 y, Schirmer I, blink interval timing and the Ocular Surface Disease Index (OSDI) questionnaire.

99 (VAS) for dry eye symptoms VAS severity, and Ocular Surface Disease Index (OSDI) questionnaire.

100 rity, Schirmer I, blink interval timing, and Ocular Surface Disease Index (OSDI) questionnaire.

101 howed 3 of the following 4 dry eye criteria: ocular surface disease index (OSDI) score of more than 1

102 Outcome variables were the Ocular Surface Disease Index (OSDI) symptom questionnair

103 Higher Ocular Surface Disease Index (OSDI) symptom scores were

104 al Function Questionnaire (NEI-VFQ), and the Ocular Surface Disease Index (OSDI) were included.

105 of dry eye disease (DED) as assessed by the Ocular Surface Disease Index (OSDI), a 12-item symptom f

106 bum quality, meibomian gland expressability, ocular surface disease index (OSDI), and standard patien

107 c tests for dry eye disease (DED), including ocular surface disease index (OSDI), tear breakup time (

108 Symptoms were evaluated using the Ocular Surface Disease Index (OSDI).

109 in (1) tear osmolarity and (2) DED symptoms (Ocular Surface Disease Index [OSDI] score) between days

110 ich included vision-related quality of life (Ocular Surface Disease Index [OSDI]), clinical examinati

111 Dry eye symptoms (Ocular Surface Disease Index [OSDI]), signs (tear break-

112 mptoms (5-Item Dry Eye Questionnaire [DEQ5], Ocular Surface Disease Index [OSDI], and Neuropathic Pai

113 onjunctival staining, meibomian grading, and Ocular Surface Disease Index and SF-36v2 questionnaires

114 After 4 weeks, the Ocular Surface Disease Index decreased significantly in

115 t months 4, 8, 12, 18 patients underwent the Ocular Surface Disease Index questionnaire (OSDI), tear

116 estionnaire (NEI-VFQ 25); and c) the 12-item Ocular Surface Disease Index Questionnaire (OSDI).

117 The Ocular Surface Disease Index questionnaire was given to

118 smometer, along with other diagnostic tests (Ocular Surface Disease Index questionnaire, Tear film br

119 articipants in the PROWL-2 study with normal Ocular Surface Disease Index scores were 44% (95% CI, 38

120 articipants in the PROWL-1 study with normal Ocular Surface Disease Index scores were 55% (95% CI, 48

121 y where the residents were studied using the Ocular Surface Disease Index, together with diagnostic t

122 festations noted were hyperopia and signs of ocular surface disease owing to nocturnal lagophthalmos

123 y of Life 17 (Glau-QoL17) questionnaire, and Ocular Surface Disease Quality of Life (OSD-QoL) questio

124 wo thirds of pediatric patients with chronic ocular surface disease related to SJS/TEN and results in

125 In a large cohort of patients with chronic ocular surface disease related to SJS/TEN, PROSE treatme

126 Here, we used a mouse model of ocular surface disease to reveal that commensals were pr

127 Ocular surface disease was significantly more common in

128 Eyelid laxity and ocular surface disease were assessed on bedside ophthalm

129 Dry eye is a complicated ocular surface disease whose exact pathogenesis is not y

130 sented with intraocular inflammation, 2 with ocular surface disease, and 1 with orbital myopathy.

131 d with greater irritation, tear instability, ocular surface disease, and blink rate.

132 -negative ulcers, viral etiology, coexistent ocular surface disease, and multiple grafts were exclude

133 VR)-induced skin pigmentation, skin cancers, ocular surface disease, and, in some patients, sunburn a

134 ta-thalassemia ocular manifestations include ocular surface disease, as demonstrated by tear function

135 method capable of assisting the diagnosis of ocular surface disease, predicting the qualities of a le

136 ective device for rehabilitation in advanced ocular surface disease, resulting in a significant impro

137 bsent ENaC function in the MG and associated ocular surface disease.

138 or serious ophthalmic complications owing to ocular surface disease.

139 developed treatment for patients with severe ocular surface disease.

140 was given to measure subjective symptoms of ocular surface disease.

141 baseline) and on postoperative day 90: MRD1, Ocular-Surface-Disease-Index (OSDI), Schirmer test 2, te

142 Except cataract surgery, all ocular surface diseases, intraocular diseases, trauma or

143 Tear film stability is the key event in ocular surface diseases.

144 accine and therapeutic development for other ocular surface diseases.

145 discuss recent advances in MSC for treating ocular surface diseases.

146 with mechanical irritation accompanying many ocular surface disorders.

147 ntity that can cause evaporative dry eye and ocular surface disruption, leading to dry eye symptoms i

148 UT and blink rate and greater irritation and ocular surface dye staining with 1 or both esthesiometer

149 rafting (MMG), prosthetic replacement of the ocular surface ecosystem (PROSE) contact lenses, or both

150 the impact of prosthetic replacement of the ocular surface ecosystem (PROSE) treatment on visual acu

151 zones is indicative of lineage, spanning the ocular surface ectoderm, lens, neuro-retina, and retinal

152 ics, resembling neuroectoderm, neural crest, ocular-surface ectoderm, or surface ectoderm.

153 es, including retinal cells, lens cells, and ocular-surface ectoderm.

154 te this we show that cells isolated from the ocular surface ectodermal zone of the SEAM can be sorted

155 mined by the direct autoimmune insult to the ocular surface epithelia, whereas in MGD patients, with

156 l of the SEAM, cells within it that resemble ocular-surface epithelia can be isolated by pipetting an

157 s, lead to an inflammatory cycle that causes ocular surface epithelial disease and neural stimulation

158 n activates stress signaling pathways in the ocular surface epithelium and resident immune cells.

159 Expression of ICAM-1 by ocular surface epithelium decreased significantly in bot

160 eye by combining in vivo PAM imaging and an ocular surface estimation method based on a machine lear

161 Patients had their ocular surface evaluated with slit-lamp biomicroscopy, a

162 ity with tear MUC5AC concentration and other ocular surface evaluation factors.

163 our knowledge, this is the first prospective ocular surface evaluation in children with EB to include

164 e and smoking questionnaires, in addition to ocular surface evaluation.

165 face Disease Index (OSDI) questionnaire, and ocular surface examination.

166 status, and medication use and underwent an ocular surface examination.

167 (3) contaminating the bottle by contact with ocular surface, eyelashes, and skin.

168 XP is frequently associated with ocular surface, eyelid, and other head and neck malignan

169 n developed that can release the drug on the ocular surface for a longer duration of time than drops,

170 We performed this study to build a new Ocular Surface Frailty Index (OSFI) and assess its predi

171 We built a tool to assess ocular surface frailty.

172 d new technologies to evaluate the tears and ocular surface have improved the ability to diagnose, cl

173 ial cell transplantation improves vision and ocular surface health and subjective visual perceptions.

174 It seems reasonable to optimize ocular surface health and to delay PK.

175 ting the pivotal role of meibum secretion in ocular surface health that should be targeted in MGD the

176 ms, the final OSFI, including 10 deficits in ocular surface health, factors potentially able to affec

177 Secondary outcomes included tolerability, ocular surface health, quality of life, disease progress

178 =50% improvement of symptoms, improvement in ocular-surface health, reduction in artificial tear use,

179 the mucous layer of the tear film to sustain ocular surface homeostasis and has potential as a novel

180 Recently, we showed an altered ocular surface homeostasis in unmanipulated NK1R(-/-) mi

181 suggesting the role of SP-NK1R signaling in ocular surface homeostasis under steady-state.

182 ecrete mucins into the tear film to preserve ocular surface homeostasis.

183 was trained end-to-end directly using 5,325 ocular surface images from a retrospective dataset.

184 fibrosis while alluding to broader roles in ocular surface immunity and allogenic organ transplantat

185 TOPIC: To discuss the pathology, causes, and ocular surface impact of meibomian gland disease (MGD),

186 terms of pathophysiology, risk factors, and ocular surface impact, and the relationship to dry eye.

187 that even PF formulations may lead to a mild ocular surface impairment.

188 tem cell transplantation, there was a stable ocular surface in 12 of 14 eyes (86%) and improvement in

189 otic membrane transplant (AMT) on the entire ocular surface in addition to the medical treatment prov

190 ort providing an up-to-dated analysis of the ocular surface in an affected patient.

191 entional MT in maintaining BCVA and a stable ocular surface in cases of acute ocular SJS.

192 late Cl(-)-driven fluid secretion across the ocular surface in mice.

193 bnormalities were in the periocular skin and ocular surface, including interpalpebral conjunctival me

194 and epidemic keratoconjunctivitis, a severe ocular surface infection.

195 pidemic keratoconjunctivitis (EKC), a severe ocular surface infection.

196 especially helpful to identify patients with ocular surface inflammation and autoimmune disease and m

197 The ocular microbiota alters ocular surface inflammation and may influence dry eye di

198 dry eye tests and identified the presence of ocular surface inflammation in 40% of confirmed dry eye

199 ural component of blueberries, in preventing ocular surface inflammation using an in vitro culture mo

200 Ocular surface inflammation was common during the acute

201 40% of SJS and 75% of TEN patients had acute ocular surface inflammation.

202 Fourteen patients (56%) presented with ocular surface inflammation.

203 Schirmer test results, and expression of the ocular surface inflammatory markers human leukocyte anti

204 types to restore the limbal niche following ocular surface injury or disease.

205 nificant improvements in tear production and ocular surface integrity were observed in patients treat

206 0 eyes) using an interferometer (LipiView(R) ocular surface interferometer, TearScience Inc, Morrisvi

207 m insufficiency and signs and/or symptoms of ocular surface irritation.

208 The ocular surface is a unique mucosal immune compartment in

209 rophils, eosinophils, and lymphocytes to the ocular surface is due to establishing various chemokine

210 to the mucosal graft when the anatomy of the ocular surface is least altered with best outcomes.

211 However, the ocular surface is one of the more complex biological bar

212 The implementation of diagnosing ocular surface lesions has been explored in previous stu

213 Aggressive ocular surface lubrication is recommended, including the

214 no ocular/adnexal tumor, 86 (72%) developed ocular surface malignancy, 15 (13%) developed eyelid mal

215 Of the 86 patients with ocular surface malignancy, 48 (56%) had unilateral tumor

216 Notch signaling pathway in regulating normal ocular surface morphogenesis and its role in the pathoge

217 on and activates mucin 5/ac synthesis during ocular surface morphogenesis.

218 nsive eye wipe behaviors when applied to the ocular surface of an awake rat.

219 vides evidence of neutrophil activity on the ocular surface of oGVHD patients.

220 chondroitin sulfate preservative free on the ocular surface of patients with dry eye disease during 6

221 bacteria did not induce inflammation on the ocular surface of rabbit eyes, with and without corneal

222 his highlights the pernicious effects on the ocular surface of the office environment, which poses a

223 When transplanted to the ocular surfaces of rabbits, the tissue survived for up t

224 Eighteen cases of ocular surface or ocular adnexal invasive squamous cell

225 We investigated the ocular surface (OS) system modifications after completel

226 significant improvement in not touching the ocular surface (P = 0.046), the eyelashes (P = 0.020), o

227 among patients with and without corneal and ocular surface pain at initial and follow-up visits over

228 ltidimensional quantification of corneal and ocular surface pain intensity, and QoL.

229 The scores of 12 ocular surface parameters correlated significantly with

230 al acuity (CDVA), severity scores of various ocular surface parameters, and the occurrence of complic

231 NaC MG KO mice (5 to 11 months), significant ocular surface pathologies were noted, including corneal

232 Lid and periocular abnormalities, ocular surface pathologies, neuro-ophthalmologic abnorma

233 egment delivery after topical application is ocular surface penetration and existing models are in vi

234 termed meibogenesis-plays a critical role in ocular surface physiology.

235 an approximately 8.5 mV hyperpolarization in ocular surface potential difference.

236 ase of CCL22 could also recruit Tregs to the ocular surface potentially mediating inflammation and sy

237 Ocular surface protection while achieving disease contro

238 ss, and therapeutic goals (improved comfort, ocular surface protection, or resolution of keratopathy)

239 and without control children, suggests that ocular surface pyogenic granulomas respond to topical ti

240 nted of 4 consecutive children with acquired ocular surface pyogenic granulomas treated at Boston Chi

241 Ocular surface reconstruction (OSR) using tissue-enginee

242 lly correctable with scar tissue removal and ocular surface reconstruction, without needing medial re

243 ee corneal epithelial tissue engineering for ocular surface reconstruction.

244 thick amniotic membrane grafts (ST-AMGs) for ocular surface reconstruction.

245 AMGs should be considered an alternative for ocular surface reconstruction.

246 s with an interest in eye development and/or ocular-surface regeneration.

247 associated with chronic inflammation of the ocular surface remain unclear.

248 In the absence of eye protection, the human ocular surface remains vulnerable to infection with aero

249 optosis and caused a severe pathology of the ocular surface resembling Meibomian gland dysfunction.

250 e of preformed mediators underlies the acute ocular surface response while the secondary influx of in

251 ); using the LogMAR scale, a multiparametric ocular surface score (OSS), and the Schirmer's test.

252 0.85; 95% CI, -0.33 to 0.62; P = .40) or an ocular surface score (regression coefficient, 1.09; 95%

253 lysis, male sex was associated with a higher ocular surface score, while older age and diabetes were

254 n was measured by the Schirmer's 1 test, and ocular surface sensitivity was measured using an aesthes

255 The total ocular surface severity scores improved from a mean preo

256 ocular surface, as assessed by change in the ocular surface severity scores was the primary outcome m

257 l domains of the OSDI, even though objective ocular surface signs are no worse.

258 ne therapy is effective not only in reducing ocular surface signs in DED patients, but also especiall

259 ents (6%) presented to ophthalmologists with ocular surface signs related to XP, before any formal di

260 reating conjunctival lesions suspected to be ocular surface squamous neoplasia (OSSN) based on the cl

261 To compare the surgical outcomes of ocular surface squamous neoplasia (OSSN) following wide

262 l features are unreliable for distinguishing ocular surface squamous neoplasia (OSSN) from benign con

263 Ocular surface squamous neoplasia (OSSN) is an aggressiv

264 terferon-alpha 2b (IFNalpha2b) treatment for ocular surface squamous neoplasia (OSSN).

265 Ocular surface squamous neoplasia in HIV-positive indivi

266 Ocular surface squamous neoplasia includes a spectrum of

267 Ocular surface squamous neoplasia specimens were analyze

268 une biomarkers, PD-L1 and PD-L2, in invasive ocular surface squamous neoplasia.

269 e, allograft OSST can provide true long-term ocular surface stability and successful visual outcomes.

270 Ocular surface stability was achieved in 72.7% (120/165)

271 ics, symptoms, best-corrected visual acuity, ocular surface stability, adverse events, and additional

272 Ocular surface stability, best-corrected visual acuity (

273 jects, blink rate positively correlated with ocular surface staining and irritation and inversely cor

274 ical signs (tear stability, tear production, ocular surface staining, bulbar and limbal redness, tear

275 evaporation, tear hyperosmolarity, increased ocular surface staining, increased inflammation, symptom

276 film break-up time, Ocular Protection Index, Ocular Surface Staining, Schirmer I test, Meibomian glan

277 lar pressure, lisamine green and fluorescein ocular surface stains.

278 of and interventions for epithelial healing, ocular surface status post healing (grade of symblepharo

279 metrics of improvement in dry eye symptoms, ocular-surface status, artificial tear use, contact lens

280 To investigate the long-term outcomes of ocular surface stem cell allograft transplantation (OSST

281 or developing advanced epithelial grafts for ocular surface surface reconstruction.

282 y preoperative sign) was a good predictor of ocular surface symptom onset (odds ratio, 9.45; 95% conf

283 eed to take glaucoma drops, not experiencing ocular surface symptoms (e.g., red eyes, teary eyes), an

284 The percentage of patients with postsurgical ocular surface symptoms was 17%.

285 helper cell 17-mediated inflammation of the ocular surface that may cause persistent damage to the c

286 Similar to other proteins placed on the ocular surface, the durability of its effect is limited

287 tes matrix metalloproteinase 9 (MMP9) at the ocular surface through a c-Fos-dependent mechanism of ER

288 Poor ocular surface, topical corticosteroid use, previous ocu

289 hitecture by use of an automated method; and ocular surface touch sensitivity by use of contact esthe

290 There were events of ocular surface tumor recurrence (n = 55 eyes, 44%), eyel

291 me measures were the occurrence of eyelid or ocular surface tumor, globe salvage, locoregional and sy

292 carcinoma (n = 51, 41%) was the most common ocular surface tumor.

293 tial, especially in screening for eyelid and ocular surface tumors.

294 to test the tolerability of bacteria on the ocular surface using in vitro and in vivo models.

295 cript explores a novel strategy to reach the ocular surface via receptor-mediated transcytosis across

296 ession of her LSCD, and stabilization of her ocular surface was achieved.

297 Ocular risk factors, especially poor ocular surface, were identified in the vast majority of

298 icelles results in enhanced contact with the ocular surface while their small size allows better tiss

299 19% of the asymptomatic patients) with frail ocular surfaces who showed a significantly higher risk o

300 Epithelialization of the ocular surface without primary symblepharon formation wa