ライフサイエンスコーパス: ocular tissue

1 rejection without inducing damage to normal ocular tissue.

2 eceptor ligand (GITRL) and its regulation by ocular tissue.

3 necrosis were histologically evident within ocular tissue.

4 during degeneration of post-mitotic cells of ocular tissue.

5 ing genes in cultured cells and in vivo into ocular tissue.

6 tative analysis of mucin expression in human ocular tissue.

7 ivated protease IV (200 ng) had no effect on ocular tissue.

8 nd modulating inflammation and thrombosis in ocular tissue.

9 the mouse genital tract and nonhuman primate ocular tissue.

10 y is essential for maintaining the health of ocular tissue.

11 Rs) are expressed in leukocytes and in every ocular tissue.

12 with those of whole embryo body (WB) lacking ocular tissue.

13 g degenerative loss of post-mitotic cells of ocular tissue.

14 s confirmed by immunohistochemistry on human ocular tissue.

15 ual Noggin producing, MyoD-positive cells in ocular tissues.

16 ession of PD-L2 on either normal or inflamed ocular tissues.

17 The FcRn receptor is expressed in multiple ocular tissues.

18 ize the distribution of the FcRn receptor in ocular tissues.

19 hus coordinating the patterning of these two ocular tissues.

20 e diffusion studies of different analytes in ocular tissues.

21 ns of these two ocular pigments in serum and ocular tissues.

22 space resulted in high levels of CsA in most ocular tissues.

23 that have previously been identified in the ocular tissues.

24 hat occur as primary and secondary tumors in ocular tissues.

25 asma lipoprotein origin accumulated in other ocular tissues.

26 tive effect through upregulation of STRA6 in ocular tissues.

27 corneal stroma and endothelium nor in other ocular tissues.

28 erformed to validate TGIF gene expression in ocular tissues.

29 gents also provide improved penetration into ocular tissues.

30 d CD63 was conducted on control and inflamed ocular tissues.

31 ed budesonide levels in the retina and other ocular tissues.

32 25 hours postinfection (PI), as measured in ocular tissues.

33 roxidase (MPO) and PLA(2) were quantified in ocular tissues.

34 inflammatory eye disease that affected most ocular tissues.

35 that negatively regulate vascular growth in ocular tissues.

36 their roles in normal, damaged, and diseased ocular tissues.

37 that TGFbeta1 can substitute for TGFbeta2 in ocular tissues.

38 r and SSTR2-ir were observed in all analyzed ocular tissues.

39 antibodies resulted in disruption of ventral ocular tissues.

40 oids at a prereceptor level in human and rat ocular tissues.

41 appears to be present in low amounts in non-ocular tissues.

42 detected in embryonic craniofacial and adult ocular tissues.

43 agnostic tool for high-resolution imaging of ocular tissues.

44 gated whether TTase is also present in other ocular tissues.

45 death caused a fourfold elevation of ET-1 in ocular tissues.

46 with the 2.4-kilobase transcript enriched in ocular tissues.

47 scale sequencing of cDNAs derived from human ocular tissues.

48 tive peptides that are widely distributed in ocular tissues.

49 cted to the lens, apply to other transparent ocular tissues.

50 as a model for the use of vitamin E by human ocular tissues.

51 ajor ALDH1 transcript in both ocular and non-ocular tissues.

52 and aging stages showed notable toxicity to ocular tissues.

53 stribution of therapeutic molecules into the ocular tissues.

54 approach and involves minimal disruption of ocular tissues.

55 to other barrier epithelia are expressed in ocular tissues.

56 omolog 1 (Siah1), was recently identified in ocular tissues.

57 o examine OA transporter expression in human ocular tissues.

58 e trabecular meshwork, optic nerve and other ocular tissues.

59 expression, indicating its direct impact on ocular tissues.

60 oprotein that is expressed in ocular and non-ocular tissues.

61 d by anticancer agents are also expressed in ocular tissues.

62 TM and CNTNAP4 were shown to be expressed in ocular tissues.

63 le-body autoradiography and radioanalysis of ocular tissues.

64 d, high-resolution cross-sectional images of ocular tissues.

65 l vectors with limited effect on surrounding ocular tissues.

66 n an imbalance of VEGF-A and sVR-1 levels in ocular tissues.

67 lates in the human plasma, major organs, and ocular tissues.

68 e marrow derived and have a slow turnover in ocular tissues (3-6 months).

69 ave shown a mechanism for HTRA1 to instigate ocular tissue abnormalities.

70 lial cells and PDGF (A- and B-chains) in the ocular tissues adjacent to the lens suggests that PDGF s

71 The ocular tissue affected by JXG included the iris (21/31,

72 These results document the first ocular tissue affected by Pitx2 gene dose in a model org

73 d epithelial (RPE) layer is one of the major ocular tissues affected by oxidative stress and is known

74 neither lack of Fas nor lack of FasL on the ocular tissues affected expression of EAU.

75 n expression profiles were examined in mouse ocular tissue after spaceflight.

76 There was no permanent histologic damage to ocular tissue after the inflammation cleared in these an

77 humanized model of MAC deposition on murine ocular tissues allows testing of human complement regula

78 ssion and release of inflammatory markers in ocular tissues, along with the attenuation of NF-kappaB

79 Previous studies have shown that ocular tissue also expresses functional Fas ligand (FasL

80 ly retaining the ability to replicate within ocular tissue and allowing the eye to serve as a portal

81 h) has been implicated in both patterning of ocular tissue and direct guidance of RGC axons.

82 ficiency leads to apoptotic defects in mouse ocular tissue and downregulation of eye development mark

83 This takes place within the ocular tissue and is supported by retinoic acid, which i

84 actors, with minimal side effects to healthy ocular tissue and other organs.

85 amide derivatives, that can permeate across ocular tissue and reduce the behavioral responses induce

86 his study was to evaluate CMV persistence in ocular tissue and to determine the potential for reactiv

87 MF is rare, but the involvement of different ocular tissues and a highly variable clinical presentati

88 These proteins interact with each other in ocular tissues and also in a heterologous system.

89 integrity and relax resistance arterioles in ocular tissues and brain through a mechanism involving a

90 In addition to ocular tissues and cartilage, opticin mRNA and protein h

91 FKN is expressed in various ocular tissues and cells.

92 Pharmacokinetic distribution in all ocular tissues and fluids was studied at 0.5, 1, 2, 4, 6

93 lls are present in diabetic fibrocontractive ocular tissues and generate tractional forces in respons

94 T had higher immune cell infiltration in the ocular tissues and higher CD4+-cell cytokine expression

95 py treatments with less collateral damage to ocular tissues and may allow reduced systemic dosage and

96 tern blot analyses of proteins from cultured ocular tissues and microdissected outer and inner retina

97 Both ocular tissues and systemic organs (brain, liver, kidney

98 type XVIII collagen is broadly expressed in ocular tissues and that it may have a role in wound heal

99 ce support greater replication and spread in ocular tissues and the nervous system.

100 melatonin receptor subtype proteins in chick ocular tissues and to examine the role of the circadian

101 support the existence of the drug target in ocular tissues and via a PPARalpha-dependent mechanism.

102 TTase was found in most ocular tissues and was concentrated in the anterior segm

103 lasts (HCF) stimulated with TGF-beta, normal ocular tissues and wounded corneas.

104 ntly identified in diabetic fibrocontractive ocular tissues and, in response to insulin-like growth f

105 athologic alterations were identified within ocular tissue, and SARS-CoV-2 RNA was localized to multi

106 t tissues of the adult human body, including ocular tissues, and a comparison of expression data with

107 ngiogenic factors in the anterior surface of ocular tissues, and analyzed the mitogenic and angiogeni

108 the increase in vascular conductance in all ocular tissues, and blocked the decrease in mean arteria

109 trum of activity, increased penetration into ocular tissues, and delayed propensity to the developmen

110 tered parasites in the retina, in nonretinal ocular tissues, and in the brain.

111 tion of EP(1) and FP receptor mRNAs in human ocular tissues appears to be localized in the functional

112 notypes raise the possibility that different ocular tissues are differently sensitive to specific mut

113 fication of analytes transport in epithelial ocular tissues are extremely important for therapy and d

114 Ocular tissues are protected by the blood-ocular barrier

115 from the posterior segment of the eye, that ocular tissues are rich in bone marrow-derived LYVE-1(+)

116 How these telencephalic and ocular tissues are specified coordinately to ensure dire

117 a normally avascular and densely innervated ocular tissue, as a model.

118 that chrdl1 is specifically expressed in the ocular tissue at late developmental stages.

119 on of the alternative pathway, especially in ocular tissues but also on a systemic level.

120 teins have been identified in high levels in ocular tissues, but no experimental model is available f

121 plice sites of AF-6 were identified in chick ocular tissues, but only two were expressed in RPE.

122 on, expression of alpha-MSH was evaluated in ocular tissue by immunocytochemistry.

123 ELOVL4 protein is evident in the ocular tissues by E10.5 and becomes restricted predomina

124 ity and blood flow, respectively, induced in ocular tissues by IV infusion of recombinant human VEGF1

125 Plasma and ocular tissue carotenoid analyses, fundus photography, a

126 was to quantify the morphological changes of ocular tissues caused by formalin fixation and cryosecti

127 usion, we found that mitotically incompetent ocular tissue cells contain adult NCDPs that exhibit a p

128 ical regulator of the developing lens, other ocular tissues, central nervous system, and pancreas.

129 In ocular tissue, CFH was detected in the distalmost optic

130 expressed in the iris and ciliary body, the ocular tissues closest to the germinative zone of the le

131 Extension of this approach to other ocular tissue components will facilitate eye disease gen

132 er the superior conjunctiva bilaterally, and ocular tissue concentration was determined using Western

133 ith L and/or Z increased the mean plasma and ocular tissue concentrations of these carotenoids and th

134 pidly growing fetal relative to normal adult ocular tissue (confirmed by RT-qPCR).

135 mouse, rat, and rabbit whole eyes and rabbit ocular tissues contained abundant amounts of C-terminal

136 determine the tropism of EBOV in 7 different ocular tissues: cornea, anterior sclera with bulbar conj

137 uxtacanalicular trabecular meshwork (TM), an ocular tissue critical for aqueous fluid outflow.

138 consists of highly organized and specialized ocular tissues critical for normal vision.

139 Also, apparently viable organisms persist in ocular tissues despite prolonged exposure to antifungal

140 that human fibroblasts derived from distinct ocular tissues differ in their responses to IL-1beta and

141 More importantly, ocular tissue displays functional TRAIL as determined by

142 These compounds demonstrate preferential ocular tissue distribution and efficacy after oral admin

143 stigate the role of CTLA-4 on CD4 T cells in ocular tissue during EAU.

144 tment of leukocytes to the immune-privileged ocular tissues during acute inflammation.

145 of CFH expression is maintained in different ocular tissues during development and aging.

146 nt expression of endogenous keratocan in non-ocular tissues during embryonic development was confirme

147 al Wnt signaling components are expressed in ocular tissues during eye development including Dkk2, en

148 Ocular tissue ET-3 levels were unaffected by diabetes.

149 E-lycopene were detected in nearly all human ocular tissues examined.

150 ributed as single cells, was detected in all ocular tissues except the central cornea.

151 Ocular tissue flatmounts from normal or enhanced green f

152 he HLA-G-1 and -5 transgenes in the targeted ocular tissues following a single intravitreal injection

153 subjects without AMD (controls), as well as ocular tissue from 40 pathological sections with AMD and

154 Ocular tissue from diabetic patients shows PAR-2 colocal

155 a v beta 3 and alpha v beta 5 in neovascular ocular tissue from patients with subretinal neovasculari

156 isease similar to that observed in diabetes, ocular tissue from transgenic mice that overexpress huma

157 We analyzed ocular tissues from abcr(-/-) mice for A2E oxiranes by m

158 Here, we identify three precursors of A2E in ocular tissues from abcr-/- mice and humans with ABCR-me

159 P) protein adducts that are more abundant in ocular tissues from AMD than normal human donors.

160 barrier and the ocular environment protects ocular tissues from autoimmune attack.

161 Ocular tissues from five time points (1, 3, 7, 14, and 3

162 r techniques in the diagnostic evaluation of ocular tissues from HTLV-1 patients, and clinical studie

163 on that may have evolved to protect delicate ocular tissues from immune-mediated damage.

164 Ocular tissues from rhesus monkeys (Macaca mulatta) were

165 Comparison of ocular tissues from seven subjects revealed no heterogen

166 ead, aqueous humor partially protected these ocular tissues from starvation-induced cell death.

167 Ocular tissues from these animals were also evaluated fo

168 ion of the laser, its biophysical effects on ocular tissues from which it derives its name (light-amp

169 Human ocular tissue gene expression analysis showed that most

170 Each of the ocular tissues had distinctive patterns of Hsp25 and -90

171 Viral transmission through ocular tissues has not been substantiated.

172 l persistence of emerging viral pathogens in ocular tissues, highlight the importance of an ophthalmi

173 l activity was transiently found in some non-ocular tissues, i.e. ears, snout, and limbs of embryos o

174 , based on DNaseI hypersensitivity data from ocular tissue in the ENCODE project.

175 on of melatonin alters the growth of several ocular tissues in both control and form-deprived eyes su

176 Histopathology showed normal ocular tissues in both dogs and rabbits 6 months after i

177 tologic evidence of immune cell reduction in ocular tissues in corticosteroid-treated eyes implies a

178 ted specification of early telencephalic and ocular tissues in humans and establish resources for stu

179 unoblot analysis and to cryostat sections of ocular tissues in immunofluorescence studies.

180 that PEDF transcripts are present in all the ocular tissues in the human eye; in the bovine eye, it i

181 d to explore the role of the conjunctiva and ocular tissues in the transmission of disease.

182 ng the interface between the SPG-178 and the ocular tissue (in this case scleral) to clear the surgic

183 293F cells and as a major band of 150 kDa in ocular tissues including ciliary body, sclera, cornea, a

184 of MAC deposition on murine cells and murine ocular tissues including RPE and cornea was developed to

185 cular region and later contribute to various ocular tissues including the cornea, ciliary body and ir

186 or proper differentiation of the surrounding ocular tissues including the cornea, iris and ciliary bo

187 ne, myocilin, is expressed in ocular and non-ocular tissues including the peripheral nervous system,

188 des were efficiently distributed to numerous ocular tissues, including retina, ciliary body, and opti

189 changes in the trabecular meshwork (TM), an ocular tissue involved in regulating IOP, which can lead

190 The ocular tissues involved in the phenotype are the retinal

191 mRNA was isolated from human ocular tissues (iris/ciliary body, retina, and choroid)

192 The presence of eosinophilic granulocytes in ocular tissue is a hallmark of the host response to envi

193 The most commonly involved ocular tissue is the eyelid skin, but intraocular involv

194 Neovascularization of ocular tissues is a major predisposing factor in scar de

195 Its occurrence on ocular tissues is even rarer.

196 To determine how HNE is detoxified in ocular tissues, its metabolism in cultured human lens ep

197 The results show that ocular tissue kills via either ligand, suggesting a comp

198 Also in contrast to the skin, pigmented ocular tissue lacked expression of the alpha-MSH ligand,

199 surements were macroscopic assessment of the ocular tissue layers and the insertion forces required f

200 venular walls in the retina and in vital non-ocular tissues (lung and liver).

201 aucoma suggests increased viscoelasticity of ocular tissues may have a protective role against glauco

202 ), that are specifically concentrated within ocular tissues, may play important roles in maintaining

203 mice suggest that control of MCMV latency in ocular tissue might involve other regulatory events that

204 by an ab interno approach, minimal trauma to ocular tissue, moderate efficacy, an excellent safety pr

205 cryosectioning are good choices for studying ocular tissue morphology and structure, as they do not c

206 f a fibrillar extracellular material in many ocular tissues, most commonly seen on the pupillary bord

207 In the rat ocular tissues mRNAs encoding glucocorticoid receptor, m

208 Outcome data were collected from the UK Ocular Tissue National Transplant database and supplemen

209 Paraffin sections of human ocular tissues obtained after death were analyzed by imm

210 and eye and a higher level of nitrite in the ocular tissue of mutant strains than in the wild type.

211 kines IL1beta and IFNgamma was quantified in ocular tissues of aire-deficient mice and patients with

212 vels, along with downregulation of ADAM17 in ocular tissues of an age-related macular degeneration mo

213 Melanin content in ocular tissues of both the strains was determined by sod

214 In ocular tissues of healthy house finches, we identified 5

215 regulated by all-trans-retinoic acid in non-ocular tissues of mice.

216 ET-3 were determined by radioimmunoassay in ocular tissues of normal rats, and in rats with streptoz

217 sion of IL1beta and IFNgamma was elevated in ocular tissues of patients with SS and aire-deficient mi

218 es are expressed in retinal and extraretinal ocular tissues of the chick eye.

219 els were detected in the normal vascularized ocular tissues of the monkey: the conjunctiva, iris, ret

220 n A contact lens is beneficial in protecting ocular tissues of the rabbit against the harmful effects

221 o protect against UVB-induced effects on the ocular tissues of the rabbit in vivo.

222 The mean levels of L and Z in plasma and ocular tissues of the rhesus monkeys increase with suppl

223 ting through specific melatonin receptors in ocular tissues, plays a role in ocular growth and develo

224 Epigenetic regulatory mechanisms in ocular tissues represent exciting areas of research that

225 disease and the number of genes expressed in ocular tissue residing on the X-chromosome.

226 Immunocytochemical analysis of chick ocular tissues revealed the cellular distribution of the

227 from June 19, 2015, through April 30, 2017, ocular tissue samples from 4 deceased fetuses with a dia

228 Ocular tissue samples from the 4 deceased fetuses (2 fem

229 DNA libraries from fetal and adult brain and ocular tissue samples were generated and used for candid

230 ug was administered, and celecoxib levels in ocular tissues (sclera, choroid-RPE, retina, vitreous, l

231 Human ocular tissue sections from patients with geographic atr

232 Immunohistochemical studies of ocular tissue showed a specific AnxA1 posttranslational

233 abcr accumulate toxic lipofuscin pigments in ocular tissues, similar to affected humans.

234 ced expression patterns of genes involved in ocular tissue specification (Pax6, Pax2, and Otx2) and d

235 role of CpG methylation in the regulation of ocular tissue-specification and described hypermethylati

236 This knowledge is particularly important for ocular tissues studies, where tissues obtained post-mort

237 is a retinol dehydrogenase expressed in non-ocular tissues such as the liver and testis and in the r

238 By contrast, ocular tissues, such as the corneal endothelium and iris

239 Moreover, expression data from ocular tissue support the role of these CNV-implicated g

240 Murine PE cells cultured from different ocular tissues suppress T cell activation by differing m

241 retain HA in the articular joint and to bind ocular tissue surfaces.

242 d samples of peripheral blood leukocytes and ocular tissue (Tenon's ocular fibroblasts).

243 The TMEM98 gene was expressed in all ocular tissues tested including sclera and optic nerve h

244 Among all the ocular tissues tested, iris showed the highest TTase act

245 The trabecular meshwork (TM) is an ocular tissue that maintains intraocular pressure (IOP)

246 with AP-2alpha expressed in a number of the ocular tissues that exhibited defects in the mutants, in

247 iven that Bves has been reported in multiple ocular tissues, the authors hypothesize that Bves plays

248 as and FasL expression on lymphocytes and on ocular tissues, the occurrence of apoptosis, and the fre

249 nti-inflammatory and antiangiogenic roles in ocular tissues through inhibition of canonical Wnt signa

250 orescence microscopy were performed on human ocular tissue to examine the in vivo protein expression

251 CFH gene and localization of this protein in ocular tissues to gain insight into its role in the eye.

252 pression, indicating that IgG transport from ocular tissues to the blood system may use this receptor

253 ates in the retina and propagates across all ocular tissues to the sclera.

254 cross-reactivity of anti-tumor T cells with ocular tissues (Type 1a) or expansion of eye-specific T

255 Thus, our results suggest that various ocular tissues up-regulate the expression of Crry and CD

256 ected and quantitated labeled carotenoids in ocular tissue using both HPLC-coupled mass spectrometry

257 Ocular tissue was analyzed histologically and in retinal

258 Microdissected eye-bank ocular tissue was characterized by western blot analysis

259 Ocular tissue was obtained from 1 patient at autopsy.

260 Plaque assay of homogenized ocular tissue was used to determine the frequency of vir

261 expression pattern of the candidate gene in ocular tissues was analyzed by reverse transcriptase-pol

262 The drug toxicity in the ocular tissues was assessed by histopathology and high-r

263 Specificity of the antibody to MMP-1 in ocular tissues was confirmed by western blot analysis wi

264 Distribution of ADM in the ocular tissues was determined by RIA.

265 , and Mel(1c) melatonin receptor proteins in ocular tissues was examined by Western blot analyses, sl

266 presence of this enzyme transcript in these ocular tissues was further confirmed by the positive slo

267 uctural organization of the retina and other ocular tissues was maintained in all experimental condit

268 Delayed appearance of macrophages in ocular tissues was observed in Tgfb2(-/-) mice.

269 ver, in situ expression of PD-L1 in inflamed ocular tissues was remarkably upregulated compared with

270 Apoptosis of inflammatory cells and cells in ocular tissues was seen, and a greater frequency of CD8(

271 To study virus-host interactions in ocular tissue, we infected primary human corneal and con

272 Single-cell suspensions from ocular tissues were also prepared and were analyzed by f

273 Ocular tissues were analyzed by immunohistology, and ser

274 Drug levels in various ocular tissues were analyzed by liquid chromatography-ta

275 ithin 38 (+/-4) hours after splashdown, mice ocular tissues were collected for analysis.

276 ours of splashdown, mice were euthanized and ocular tissues were collected for analysis.

277 s of various adrenergic antagonists in these ocular tissues were compared with their affinities for t

278 ear factor kappa B (NF-kappaB) expression in ocular tissues were determined immunohistochemically.

279 The drug affinities in all four human ocular tissues were highly correlated (correlation coeff

280 om nondiabetic rats and separated from other ocular tissues were incubated for several hours in incub

281 al edema, with minimal or no inflammation in ocular tissues were observed in all 21 cases evaluated.

282 Ocular tissues were obtained from 25 patients with COVID

283 Ocular tissues were obtained from 58 dogs with mucopolys

284 Ocular tissues were obtained from six aged control donor

285 18 concentration time profiles in plasma and ocular tissues were quantified by liquid scintillation c

286 properties of small specimens of orbital and ocular tissues were reliably characterized over a wide r

287 Total RNA extracted from human and bovine ocular tissues were screened by Northern blot analysis w

288 id absorption, and transport from serum into ocular tissues were similar to results observed in most

289 The carotenoid profiles in quail and frog ocular tissues were somewhat similar to those in humans,

290 Parabulbar and ocular tissues were studied by light microscopy for evid

291 es and have not evaluated cells derived from ocular tissue, which better represent the glaucomatous d

292 he trabecular meshwork (TM) is a specialized ocular tissue, which is responsible, together with the S

293 at these receptors are present in mammalian ocular tissues, which regulate aqueous humor formation a

294 AC-II and AC-IV were characterized in ocular tissue with reverse transcription-polymerase chai

295 ha v beta 3 was observed on blood vessels in ocular tissues with active neovascularization from patie

296 al drops the exposure was minimal in all the ocular tissues with greater systemic exposure.

297 f type XVIII collagen was performed in mouse ocular tissue, with polyclonal antibodies to the hinge d

298 ectioning caused only minimal changes to the ocular tissues, with average percentage parameter differ

299 abeled AMG 386 was widely distributed across ocular tissues, with highest concentrations in the choro

300 odifying the refractive index of transparent ocular tissues without apparent tissue destruction.