ライフサイエンスコーパス: oculomotor

1 The oculomotor abnormalities with isolated infarction of the

2 ith gait ataxia, dysarthria, dysmetria, mild oculomotor abnormalities, and diffuse cerebellar atrophy

3 ink between tactile temporal expectation and oculomotor action.

4 odal coupling between tactile perception and oculomotor action.

5 d emotional face information guides distinct oculomotor actions depending on the type of threat conve

6 a quantifiable trial-by-trial reflection of oculomotor activation, comparable to the monosynaptic mo

7 e activity provides a sensitive indicator of oculomotor activation, we show that single pulses of TMS

8 timulation pulses and varied with endogenous oculomotor activity at the time of stimulation.

9 ir eyes, and it has long been suggested that oculomotor activity enhances fine pattern vision.

10 evoked from the FEFs increased when presumed oculomotor activity was higher at the time of stimulatio

11 s a method to augment existing therapies for oculomotor alignment disorders.

12 of the split LR muscle can achieve excellent oculomotor alignment in some cases of third nerve palsy.

13 Oculomotor analyses revealed specific deficits related t

14 le phenotypes that include misrouting of the oculomotor and abducens nerves.

15 ns and suggest that the interrelationship of oculomotor and attention-related mechanisms extends to p

16 wing condition, thereby producing equivalent oculomotor and behavioural engagement.

17 hat suggest fundamental similarities between oculomotor and cephalomotor control, as well as a concep

18 FEF microcircuitry and its contributions to oculomotor and cognitive functions.SIGNIFICANCE STATEMEN

19 emonstrates the dose-dependent impairment in oculomotor and ocular behaviours across a range of ultra

20 ted the dose dependence of the impairment in oculomotor and ocular behaviours caused by EtOH administ

21 We took repeated measures of oculomotor and ocular performance from sixteen participa

22 We evaluated the framework in a series of oculomotor and reaching decision tasks and found that it

23 irection, but its role in the integration of oculomotor and visual orientation signals for updating g

24 ific cortical modules for the integration of oculomotor and visual signals for grasp updating.SIGNIFI

25 tion of the image-forming, nonimage forming, oculomotor, and accessory optic, vision-associated syste

26 The prefrontal cingulate area (Cg), visual, oculomotor, and auditory areas provide strong input to t

27 Manual, oculomotor, and perceptual sequence learning all support

28 onsistent phenotype of recessive ataxia with oculomotor apraxia (AOA).

29 hic lateral sclerosis (ALS4) and ataxia with oculomotor apraxia (AOA2).

30 ith three neuropathological diseases: ataxia oculomotor apraxia 1, spinocerebellar ataxia with neuron

31 d by heritable APTX mutations in ataxia with oculomotor apraxia 1.

32 and that, if mutated, results in ataxia with oculomotor apraxia 4 (AOA4) and microcephaly with early-

33 gressive cerebellar degeneration, ataxia and oculomotor apraxia in man.

34 APTX-deficient cell lines, human Ataxia with Oculomotor Apraxia Type 1 (AOA1) and DT40 chicken B cell

35 Ataxia oculomotor apraxia type 1 (AOA1) is an autosomal recessi

36 Ataxia with oculomotor apraxia type 1 (AOA1) is an early onset progr

37 ETX cause the recessive disorder ataxia with oculomotor apraxia type 2 (AOA2) and a dominant juvenile

38 two neurodegenerative disorders: ataxia with oculomotor apraxia type 2 (AOA2) and amyotrophic lateral

39 Ataxia oculomotor apraxia type 2 (AOA2) is a rare autosomal rec

40 by congenital cerebellar ataxia, hypotonia, oculomotor apraxia, and mental retardation.

41 e mid-hindbrain and cerebellar malformation, oculomotor apraxia, irregular breathing, developmental d

42 otonia, developmental delay, typical facies, oculomotor apraxia, polydactyly, and subtle posterior fo

43 izures (MCSZ) to neurodegeneration in ataxia oculomotor apraxia-4 (AOA4) and Charcot-Marie-Tooth dise

44 isability, profound ataxia, camptocormia and oculomotor apraxia.

45 sponses of neurons in every known visual and oculomotor area, but whether such modulations can accoun

46 nce, using eye tracking to measure implicit (oculomotor) avoidance of disgusting images (feces) befor

47 pha2-chimaerin signaling is required for key oculomotor axon guidance decisions, and provide a zebraf

48 Accordingly, during oculomotor behavior in mice and rhesus monkeys, mean irr

49 y, despite the drastic changes introduced by oculomotor behavior in real life.

50 This link between auditory expectation and oculomotor behavior reveals a multimodal perception acti

51 The results suggest that free-viewing oculomotor behavior reveals cognitive and emotional fact

52 ideo of the real-life visual scene, and free oculomotor behavior were simultaneously recorded in huma

53 ances on the mechanisms and purposes of fine oculomotor behavior, a rigorous assessment of the precis

54 it is outside the temporal regime of typical oculomotor behavior.

55 uit-specific requirements for dscaml1 during oculomotor behavior.

56 aging and single-cell electroporation during oculomotor behaviors to map VPNI neural activity in zebr

57 at exploration and fixation are two distinct oculomotor behaviors.

58 therefore essential for reliable read-out of oculomotor behaviour.

59 Oculomotor behaviours are commonly used to evaluate sens

60 Changes in oculomotor behaviours are often used as metrics of senso

61 reflected in the ongoing neural activity in oculomotor brain circuits, it is not known whether the d

62 ynamical characterization of attentional and oculomotor capture that is not only qualitatively consis

63 F pathway, which was correlated with greater oculomotor CD abnormalities and more severe psychotic sy

64 s) via the mediodorsal thalamus (MD) conveys oculomotor CD associated with saccadic eye movements in

65 nnectivity of this MD-FEF pathway relates to oculomotor CD functioning in schizophrenia.

66 e role of the MD-FEF pathway in transmitting oculomotor CD signals and suggest that disturbances in t

67 igate is the superior colliculus, a midbrain oculomotor center responsible for the generation of sacc

68 These results suggest that oculomotor centers keep track of visual, auditory and au

69 h modalities are represented in eye-centered oculomotor centers.

70 nd medial subdivisions, which project to the oculomotor cerebellum and the vestibulocerebellum.

71 In contrast, projections to the oculomotor cerebellum in hummingbirds and zebra finches

72 s from the lateral LM; the projection to the oculomotor cerebellum largely arises from the medial LM.

73 plays a key role in assembling a functional oculomotor circuit.

74 d find that contrary to the classical model, oculomotor circuits in hindbrain rhombomeres 5-6 develop

75 Information flows from prefrontal to oculomotor circuits in the striatum, and directional err

76 Probing the oculomotor circuits with these decision-irrelevant sacca

77 dscaml1 resulted in impairments in specific oculomotor circuits, providing a new animal model to inv

78 y for a comprehensive assembly of functional oculomotor circuits.

79 the incoming retinal signals lead to robust oculomotor commands because corrections are observed if

80 s time-varying retinal signals into saccadic oculomotor commands.

81 sed saccade curvature to investigate whether oculomotor competition across eye movements is represent

82 formed a sequence of saccades and we induced oculomotor competition by briefly presenting a task-irre

83 lei related to motor function, including the oculomotor complex and motor nucleus of the fourth, fift

84 ntion [4-10] and for mediodorsal thalamus in oculomotor control [11].

85 s species for decades, circuit mechanisms of oculomotor control and adaptation remain elusive.

86 r the pervasiveness of visual sensitivity in oculomotor control brain regions.

87 Oculomotor control calls on a distributed set of brain s

88 al cortex that has descending projections to oculomotor control centers.

89 ntate nuclei (DN) contribution to volitional oculomotor control has recently been hypothesized but no

90 We tested parietal neurons involved in oculomotor control in a task in which monkeys made sacca

91 tail and suggest that a reduced precision in oculomotor control may be responsible for the visual acu

92 ditionally to maintain the accuracy of these oculomotor control processes across the lifespan, ongoin

93 ally, text is presented binocularly, and the oculomotor control system precisely coordinates the two

94 c consequence of damage to the substrates of oculomotor control, often is resistant to pharmacotherap

95 etal brain areas that play a pivotal role in oculomotor control, such as the lateral intraparietal co

96 Caffeine exerts a protective effect on oculomotor control, which could be related to up-regulat

97 es a unique opportunity to study DN in human oculomotor control.

98 d apply these tools to a classic question in oculomotor control.

99 bdivisions, with the former also involved in oculomotor control.

100 The properties of the oculomotor corollary discharge can be probed by asking s

101 ve shown that some distance cues, especially oculomotor cues such as vergence and accommodation, can

102 To investigate the consequences of this oculomotor cycle on the dynamics of perception, we combi

103 ay builds on the information dynamics of the oculomotor cycle.

104 thought to mediate response selection during oculomotor decision tasks.

105 w that parietal cortical neurons involved in oculomotor decisions encode, before an information sampl

106 ings suggest that parietal cells involved in oculomotor decisions show uncertainty-dependent boosts o

107 nerve myelin sheath formation and results in oculomotor deficits sharing many features with our patie

108 al/brainstem motor system generating greater oculomotors deficits and swallowing difficulty; atrophy

109 etal cortical areas in monkeys performing an oculomotor, delayed match-to-sample task.

110 new type of eye movement serving a distinct oculomotor demand, namely the resetting of eye torsion,

111 The frequency of receded NPC and oculomotor diagnoses were determined.

112 ual learning supported generalisation to the oculomotor direct tests but did not support the consciou

113 find that domperidone significantly reduces oculomotor disgust avoidance following incentivized expo

114 potential circuit deficits underlying human oculomotor disorders.

115 Of these, 70 (95%) had oculomotor disorders; 30 (41%) had disorders of accommod

116 y provides strong evidence that, even though oculomotor distance cues have been shown to modulate the

117 contrast to informal clinical evaluations of oculomotor dysfunction frequency (previous studies: 38%,

118 Because treatment options for the various oculomotor dysfunctions differ, it is prudent that these

119 Associated with numerous underlying oculomotor dysfunctions, the clinical finding of a reced

120 eye's orbit and extra-ocular muscles, or in oculomotor dysfunctions.

121 dy shows that dscaml1 mutants have a host of oculomotor (eye movement) deficits.

122 These findings portray oculomotor freezing as a marker of crossmodal temporal e

123 th reduced task performance, suggesting that oculomotor freezing mitigates potential detrimental, con

124 Our results demonstrate that oculomotor function can be affected by decision formatio

125 Oculomotor function critically depends on how signals re

126 re have been no systematic analyses of basic oculomotor function in this population.

127 isually evoked eye movements rapidly restore oculomotor function in wild-type mice but are profoundly

128 The oculomotor function remained intact.

129 othesis that the NPH, beyond its traditional oculomotor function, plays a critical role in conveying

130 the AER, restoring lost higher control over oculomotor function.

131 m frontal areas that have been implicated in oculomotor functions, whereas area 6Va received stronger

132 We define the oculomotor horopter: the surface of 3D positions to whic

133 ion value for paralyzed patients with severe oculomotor impairments.

134 finding reveals that the visual system uses oculomotor-induced temporal modulations to sequentially

135 These results suggest that oculomotor influences on visual processing, long thought

136 the main target of stabilizing extra-retinal oculomotor influences.

137 d subjects' gaze, thus overlooking potential oculomotor influences.

138 These results show that oculomotor information variably enhances auditory spatia

139 This oculomotor inhibition effect could be considered a marke

140 These findings show that oculomotor inhibition occurs prior to auditory targets.

141 prefrontal saccade regions (consistent with oculomotor input) and anterior intraparietal sulcus/supe

142 tion comes from visually guided reaching and oculomotor integration, in which the time course and tra

143 sired eye position was imaged throughout the oculomotor integrator after saccadic or optokinetic stim

144 ioral benefit possibly arising from auditory-oculomotor interactions at an earlier level of processin

145 HCI H2-K(b)/H2-D(b) (K(b)D(b-/-)), exhibited oculomotor learning deficits.

146 Oculomotor learning supported the use of conscious knowl

147 o examine this process, we designed a set of oculomotor learning tasks with more than one visual obje

148 error signals to reach the flocculus during oculomotor learning.

149 these results, we suggest a novel theory for oculomotor learning: a distributed representation of lea

150 of the gaze control system, irrespective of oculomotor limitations.

151 The oculomotor loop controls eye movements and can direct re

152 re of failure of prefrontal control over the oculomotor loop.

153 es, but also suggest nonmotor recruitment of oculomotor machinery in decision making.

154 tions in retinotopicaly organized visual and oculomotor maps.

155 directly fit the synaptic connectivity of an oculomotor memory circuit to a broad range of anatomical

156 iour, it did influence spatial selection and oculomotor metrics in a free-choice control task.

157 oculomotor targets rather than generation of oculomotor movements.

158 ion of the lateral rectus muscle by aberrant oculomotor nerve branches, which form at developmental d

159 eceptor CXCR4 and its ligand CXCL12 regulate oculomotor nerve development; mice with loss of either m

160 ation of the lateral rectus by fibers of the oculomotor nerve in DRS is secondary to absence of the a

161 All embryos show oculomotor nerve misrouting, ranging from complete mispr

162 s is an institutional study on patients with oculomotor nerve palsy with aberrant innervation who had

163 a selective vulnerability of the developing oculomotor nerve to perturbations of the axon cytoskelet

164 The developing axons of the oculomotor nerve's superior division stall in the proxim

165 ervation of the lateral rectus muscle by the oculomotor nerve.

166 ervation of the lateral rectus muscle by the oculomotor nerve.

167 motor structures in the midbrain, including oculomotor nerves or nuclei, vertical supranuclear sacca

168 The hippocampus and the oculomotor network are well connected anatomically throu

169 step trials, greater activation in a frontal oculomotor network, including frontal and supplementary

170 SIGNIFICANCE STATEMENT: The hippocampal and oculomotor networks have each been studied extensively f

171 ontrolling jaw musculature and ALS-resistant oculomotor neurons (OMNs) controlling eye musculature in

172 nship between populations of visual neurons, oculomotor neurons and behavior during detection and dis

173 All subgroups of oculomotor neurons are present, as well as their input a

174 hat disrupting cadherin adhesivity in dorsal oculomotor neurons impairs the larval optokinetic reflex

175 ion in zebrafish, and increase the number of oculomotor neurons in the developing mouse in vitro and

176 Manipulation of chimaerin signaling in oculomotor neurons in vitro led to changes in microtubul

177 obe spatial and temporal organization of the oculomotor (nIII) and trochlear (nIV) nuclei in the larv

178 MIF motoneurons lie around the periphery of oculomotor nuclei and have premotor inputs different fro

179 the NPH has historically been defined as an oculomotor nuclei and therefore its role in contributing

180 in the anteromedian nucleus and between the oculomotor nuclei.

181 ted ventrolaterally and rostrally within the oculomotor nucleus (III).

182 Within the oculomotor nucleus, a much sparser ipsilateral projectio

183 of A- and B-group motoneurons lay within the oculomotor nucleus, but those of the C-group motoneurons

184 lar formation (cMRF), located lateral to the oculomotor nucleus, contains premotor neurons potentiall

185 In the oculomotor nucleus, CR was specifically found in punctat

186 c neuron, interneuron, abducens nucleus, and oculomotor nucleus, is developed to examine saccade dyna

187 ie adjacent to the dorsomedial border of the oculomotor nucleus, whereas MR neurons are located farth

188 ich lies rostral, dorsal, and ventral to the oculomotor nucleus.

189 re found caudally, dorsal and ventral to the oculomotor nucleus.

190 s in vitro and in vivo, but has no effect on oculomotor or red nucleus neurogenesis.

191 In both manual (covert) and oculomotor (overt) response modalities, and in both huma

192 The combination of the well-tolerated oculomotor paradigm and the sensitivity of the model-bas

193 Using a novel oculomotor paradigm, combined with reinforcement learnin

194 which neuronal responses remain invariant to oculomotor parameters and viewing conditions.

195 s review primarily discusses the role of the oculomotor part of the vermal cerebellum [the oculomotor

196 A non-oculomotor perceptual task (global motion processing) wa

197 , this view is contrary to the idea that the oculomotor periphery has privileged access to short-late

198 Notably, the oculomotor phenotypes in dscaml1 mutants are reminiscent

199 e relative contribution of each input to the oculomotor physiology, single-unit recordings from media

200 suggest task specificity in the learning of oculomotor plans in response to changes in front-end sen

201 e domain-specific representations of learned oculomotor plans in the brain.SIGNIFICANCE STATEMENT The

202 instantiated in FEF as a competition between oculomotor plans, in agreement with model predictions.

203 idbrain is presented to drive a muscle fiber oculomotor plant during horizontal monkey saccades.

204 Such oculomotor plasticity has generally been studied under c

205 Here we examine oculomotor plasticity when error signals are independent

206 sing these interneuronal correlations yields oculomotor predictions that are more accurate and also l

207 imal model to investigate the development of oculomotor premotor pathways and their associated human

208 We suggest the posterior cortical atrophy oculomotor profile (e.g. exacerbation of the saccadic ga

209 ial attention is not coupled to the executed oculomotor program but instead can be deployed unrestric

210 rming that covert attention is not driven by oculomotor programming.

211 successful implantation of a novel magnetic oculomotor prosthesis in a patient.

212 2-part, titanium-encased, rare-earth magnet oculomotor prosthesis, powered to damp nystagmus without

213 new field of implantable therapeutic devices-oculomotor prosthetics-designed to modify eye movements

214 was presented within or beyond participants' oculomotor range during both fixation and saccade prepar

215 ent disorders and healthy participants whose oculomotor range had been experimentally reduced have be

216 restricted to locations within the so-called oculomotor range that is accessible by saccadic eye move

217 ts to locations within and beyond observers' oculomotor range via their disruptive, attention capturi

218 genous attention both inside and outside the oculomotor range, demonstrating that exogenous attention

219 al cue was presented inside or outside their oculomotor range.

220 ations either within or beyond participants' oculomotor range.

221 oss blinks or might depend on a more general oculomotor recalibration mechanism adapting gaze positio

222 to be adaptively adjusted relative to other oculomotor reflexes and thereby ensuring image stability

223 During delayed oculomotor response tasks, neurons in the lateral intrap

224 auditory midbrain nucleus, shows visual and oculomotor responses [4-6] and modulations of auditory a

225 tion, as evident in trial-to-trial imprecise oculomotor responses.

226 st the C-group motoneurons serve a different oculomotor role than the others.

227 related with increased activation across the oculomotor saccade system.

228 balance of this competition-as reflected in oculomotor signatures of internal attention-predicts the

229 ric disorders, producing measurable atypical oculomotor signatures.

230 spondingly, excess CXCL12 applied to ex vivo oculomotor slices causes axon misrouting, similar to inh

231 interpreted as a priority map for saccades (oculomotor-specific) or a salience map of space (not eff

232 t corollary discharge signal is generated by oculomotor structures and communicated to sensory system

233 ether the decision-related activity in those oculomotor structures interacts with eye movements that

234 Although the motor-related activity within oculomotor structures seems a likely source of the enhan

235 ive mixture of motor and decision signals in oculomotor structures, but also suggest nonmotor recruit

236 Oculomotor studies in ALS have described deficits in ant

237 edicted individual differences in associated oculomotor switch costs, reflecting reactive reconfigura

238 nesis in mice, while reduced function causes oculomotor synkinesis in humans.

239 the oculomotor system; complete loss causes oculomotor synkinesis in mice, while reduced function ca

240 Oculomotor synkinesis is the involuntary movement of the

241 ment; mice with loss of either molecule have oculomotor synkinesis.

242 are elicited by preceding activation in the oculomotor system [2], it has been claimed that attentio

243 this study we examine central fatigue in the oculomotor system after prolonged exercise.

244 We conclude that the oculomotor system also participates in focusing attentio

245 ings therefore demonstrate a coupling of the oculomotor system and ongoing heartbeat, which provides

246 Our findings implicate the oculomotor system as a potential substrate for how cogni

247 e results advance the suitability of the NHP oculomotor system as an animal model for TMS.

248 Here, we demonstrate that the oculomotor system can spontaneously and rapidly adopt a

249 Here, we show that the oculomotor system constantly recalibrates gaze direction

250 The oculomotor system contains a simple example, a hindbrain

251 logically plausible, none have looked to the oculomotor system for design constraints or parameter sp

252 cts retinal image slip and reports it to the oculomotor system for reflexive image stabilization.

253 observation, it has been postulated that the oculomotor system has access to hand efference copy, the

254 A leading hypothesis is that the oculomotor system has access to hand motor signals.

255 It is currently thought that the primate oculomotor system has evolved distinct but interrelated

256 d clear evidence for dysfunctional CD in the oculomotor system in patients with schizophrenia.

257 Our results highlight the flexibility of the oculomotor system in reacting to environmental events an

258 The oculomotor system incorporates the oculomotor, trochlear

259 The oculomotor system integrates a variety of visual signals

260 The impact of central fatigue on the oculomotor system is currently unexplored.

261 The human oculomotor system is impaired by strenuous exercise of t

262 The oculomotor system keeps the eyes steady in expectation o

263 r also accompany covert orienting; hence the oculomotor system may provide an alternative substrate f

264 Encoding horizontal eye position in the oculomotor system occurs through temporal integration of

265 The oculomotor system of nonhuman primates (NHPs) offers a p

266 Here we investigate whether the oculomotor system of the brain also participates in atte

267 mate, because both the visual system and the oculomotor system process information faster.

268 While it has been proposed that the oculomotor system quickly updates and informs the visual

269 mination task enabled us to test whether the oculomotor system shows an analogous preparatory respons

270 e fields (FEFs), a cortical component of the oculomotor system strongly connected to the intermediate

271 The oculomotor system therefore provides a plausible pathway

272 ned that, if the output of M1 is used by the oculomotor system to keep track of the target, on top of

273 Efference copy from the oculomotor system to the visual system has been suggeste

274 ine-tuning eye movements extends even to the oculomotor system's smallest saccades and add to a growi

275 ral evidence of altered CD, including in the oculomotor system, has been observed in schizophrenia pa

276 n previously, pursuit trials potentiated the oculomotor system, producing anticipatory eye velocity o

277 t, if hand motor signals are accessed by the oculomotor system, this is upstream of M1.

278 t, if hand motor signals are accessed by the oculomotor system, this is upstream of M1.SIGNIFICANCE S

279 larval zebrafish (sexually undifferentiated) oculomotor system, where behavior, circuit function, and

280 visual stimulation, and are specific to the oculomotor system.

281 fore the efference copy could be used by the oculomotor system.

282 important regulator of axon guidance in the oculomotor system; complete loss causes oculomotor synki

283 l analysis of the accommodation and vergence oculomotor systems with a view to understanding factors

284 cate greater impairment of identification of oculomotor targets rather than generation of oculomotor

285 accades and antisaccades, a well established oculomotor task for testing cognitive control.

286 Combining TMS with an oculomotor task revealed state dependency, with TMS evok

287 dings from previous eye movement research on oculomotor tasks and saliency analyses during natural im

288 Many oculomotor tasks depend on integration of eye-velocity s

289 estigated PFC functions with arm-reaching or oculomotor tasks, thus leaving unclear whether, and to w

290 laminae provides a subcortical basis for the oculomotor theory of attention.

291 manual baseline condition and the manual to oculomotor transfer condition differed in the magnitude

292 tions given by different eye movements, with oculomotor transitions primarily acting by regulating th

293 f transgene expression, whereas those in the oculomotor, trigeminal, and facial nuclei are spared.

294 The oculomotor system incorporates the oculomotor, trochlear and abducens cranial nerve nuclei

295 , and visual nuclei) and motor nuclei (e.g., oculomotor, trochlear, trigeminal motor, abducens, and v

296 culomotor part of the vermal cerebellum [the oculomotor vermis (OMV)] in the control of visually guid

297 Optical stimulation of the oculomotor vermis caused saccade dysmetria.

298 lude that the plasticity at the level of the oculomotor vermis is more fundamentally important for fo

299 e we analysed Purkinje-cell discharge in the oculomotor vermis of behaving rhesus monkeys (Macaca mul

300 xhibited stimulus specificity, including the oculomotor vermis, a key area associated with eye moveme