ライフサイエンスコーパス: odorant

1 evated 7 days after exposure to the aversive odorant.

2 but increase odor response if mixed with an odorant.

3 they refrain from licking for the unrewarded odorant.

4 he conditioned and less to the unconditioned odorant.

5 d a stronger percentage of 'chemical' impact odorants.

6 the MLI responses did not differ between the odorants.

7 the perception of smells to the chemistry of odorants.

8 o complex mixtures using responses to single odorants.

9 HP and TD, based on the concentrations of 23 odorants.

10 e attraction to body heat as well as to skin odorants.

11 ficult task using mixtures of highly similar odorants.

12 ysically mixed with activating human-derived odorants.

13 G contained the lowest levels of most of the odorants.

14 emical and perceptual characteristics of the odorants.

15 bGCs were strongly and broadly responsive to odorants.

16 y in MB neurons, altering their responses to odorants.

17 n on the intra-oral aroma release of certain odorants.

18 nes, and a range of more traditional general odorants.

19 actory bulb of mice learning to discriminate odorants.

20 ase for rewarded and decrease for unrewarded odorants.

21 E. viridissima is broadly tuned to multiple odorants.

22 to be activated in combinatorial fashion by odorants.

23 floral and fecal odors-by a set of 36 tested odorants.

24 show excitatory responses are excited by one odorant, 1-octen-3-ol, which is contained in host emanat

25 droxycitronellyl acetate as the least potent odorant (1261ng/Lair).

26 the extent of perceptual similarity between odorants(2).

27 offspring to these odors, expression of M71 odorant (Ace-responsive) and MOR23 odorant (Lyral-respon

28 odor quality.Humans and animals recognize an odorant across a range of odorant concentrations, but wh

29 e also discovered several previously unknown odorants activating MOR18-2 glomeruli, and obtained deta

30 directed antagonists allosterically inhibit odorant activation of ORs and we previously showed that

31 during tasting, by retronasal perception of odorant aglycones released in-mouth.

32 SPW exposures, olfactory responses to a food odorant and a pheromone were reduced to a similar degree

33 ided identification of chavibetol as the key odorant and antioxidant in the betel (Piper betle L., Ba

34 lick a spout in the presence of the rewarded odorant and avoid a timeout when they refrain from licki

35 om licking in the presence of the unrewarded odorant and had difficulty becoming proficient when MLIs

36 e abolishes iL3 attraction to a host-emitted odorant and prevents activation.

37 dipped staves and micro-oxygenation), on the odorant and sensory profile of a wine spirit, using Limo

38 suppresses behavioral odor responses across odorants and concentrations.

39 c response profiles to a diagnostic panel of odorants and identified three paralogous receptors-Olfr7

40 he shape of temporal response filters across odorants and ORNs extend these relationships to fluctuat

41 Sensitivities across odorants and ORNs follow a power-law distribution.

42 sory signaling molecules including air-borne odorants and pheromones.

43 xtracting new knowledge linking chemistry of odorants and psychology of smells, our results provide a

44 A good relation among the impact odorants and the sensory descriptors was observed.

45 nts who smelled 242 different multicomponent odorants and used these data to refine a predictive mode

46 oncentrations, detection thresholds of three odorants, and general olfactory acuity.

47 In complex mixtures of up to 12 odorants, antagonistic interactions are stronger and mor

48 In aquatic and terrestrial environments, odorants are dispersed by currents that create concentra

49 demonstrate that representations of similar odorants are maximally separated, measured by the distan

50 d in the piriform cortex, whose responses to odorants are sparsely distributed across the cortex.

51 ion, two key characteristics of the space of odorants, are encoded by the odorant transduction proces

52 e perceived intensity and pleasantness of 68 odorants at two concentrations, detection thresholds of

53 hila larva across a broadly sampled panel of odorants at varying concentrations.

54 targets that will aid in the development of odorant-based fly management strategies.

55 over time, with representations of different odorants becoming more distinct.

56 Odorant binding data suggests that these variants lead t

57 belong to major urinary protein ("MUP") and odorant binding protein ("OBP") families.

58 ito led to an in increased expression of the odorant binding protein 22 (AeOBP22) within the mosquito

59 signal of divergent selection, including an odorant binding protein and another in close proximity w

60 , Wigglesworthia, up-regulates expression of odorant binding protein six in the gut of intrauterine t

61 Odorant binding proteins (Obps) are expressed at extreme

62 develop sensitive olfactory biosensors using odorant binding proteins (OBPs) as sensing materials.

63 The binding pockets of odorant binding proteins from Anopheles gambiae (OBP1 an

64 sory related genes are repressed, especially odorant binding proteins.

65 aking advantage of the tertiary structure of odorant binding proteins.

66 ors (ORs) are believed to be a complex of an odorant binding subunit, OrX, and an ion channel forming

67 mJHBP is a member of the odorant-binding protein (OBP) family, and orthologs are

68 Herein, we identified a total of 25 putative odorant-binding receptors (OBPs), 4 single-copy chemosen

69 useful in further expanding our knowledge of odorant-binding site structures in ORs of disease vector

70 unctional analyses using agonists to map the odorant-binding sites of these receptors have been limit

71 tse-specific genes are enriched in protease, odorant-binding, and helicase activities.

72 We discover an expansion of odorant-binding-protein genes, some expressed specifical

73 ept for their increased responses to several odorants, blood-fed mosquitoes generally evoked reduced

74 onstrate sexually dimorphic neural coding of odorants by olfactory sensory neurons (OSNs), primary se

75 w that protracted exposure to kin or non-kin odorants changes the number of dopamine (DA)- or gamma a

76 rst, we built a new database containing 1689 odorants characterized by physicochemical properties and

77 nd its olfactory mode of action requires the odorant co-receptor orco [2, 3, 6].

78 ory sensilla that respond to human or animal odorants, CO(2), sex and alarm pheromones, or other odor

79 In total, 35 odorant compounds were detected.

80 Eight odorant compounds, such as trimethylamine, 1-octen-3-one

81 levant physical characteristics of component odorant-compounds.

82 the neural code of both odorant identity and odorant concentration and advances the state-of-the-art

83 ding, and the resulting relationship between odorant concentration and the bound receptor fraction is

84 as captured by the Hill equation, transforms odorant concentration into response levels in a way that

85 ceptor binding rate tensor, modulated by the odorant concentration profile, and an odorant-receptor d

86 imals recognize an odorant across a range of odorant concentrations, but where in the olfactory proce

87 from the input and output across a range of odorant concentrations.

88 The quantitative reduction of these odorants correlated with the organoleptic difference.

89 I calcium responses, and the identity of the odorant could be decoded from the differential response.

90 Odorant-dependent behaviors in insects are triggered by

91 lation state of Orco (S289) is altered in an odorant-dependent manner and changes in phosphorylation

92 By measuring odorant-dependent sniffing, we gain a sensitive measure

93 Results showed odorants differed significantly in habituation, highligh

94 coded from peak PRP in animals proficient in odorant discrimination, but not in naive mice.

95 The odorant-dissociation rate is only available for a few od

96 intraorally delivered tastants and tasteless odorants dissolved in water and whether/how these two mo

97 similar responses to palatable tastants and odorants dissolved in water.

98 .SIGNIFICANCE STATEMENT Repeated sampling of odorants during high-frequency respiration (sniffing) is

99 ncrease in the intra-oral release of certain odorants (e.g. linalool, beta-ionone), while flavonoids

100 nd in their ratio of natural emission, these odorants elicit attraction by host-seeking mosquitoes, e

101 With learning, the rewarded odorant elicited a large increase in MLI calcium respons

102 PAC changes throughout learning, and odorant-elicited changes in PRP increase for rewarded an

103 The odorants eliciting diminished responses in female mosqui

104 nd antennal lobe responses to representative odorants emitted by D. wrightii In a wind-tunnel setting

105 rsistently reduced behavioral response to an odorant encountered for 4 continuous days and occurs tog

106 rties, that together preserved the timing of odorant encounters in ORN spiking, regardless of intensi

107 male and female mice was not perceived as an odorant equivalent cue.

108 ld be replaced by a vector containing just 3 odorants (ethyl 2-methylbutyrate, ethyl butyrate and hex

109 in vivo optical neurophysiology to visualize odorant-evoked OSN synaptic output into olfactory bub gl

110 s network transformed glomerular patterns of odorant-evoked sensory input (taken from previously-publ

111 e (ASM) and uncovered a complex mechanism of odorant-evoked signaling properties that regulate excita

112 clinically relevant odor consisting of >400 odorants, evokes responses from 144 ORs and 3 TAARs in f

113 phosphorylated in the sensitized state, and odorant exposure triggers dephosphorylation and desensit

114 at this residue is dynamically regulated by odorant exposure with concomitant modulation of odorant

115 istance between MBON activity vectors of two odorants for the same level of KC population sparseness.

116 tual similarity estimates of 49,788 pairwise odorants from 199 participants who smelled 242 different

117 The recent discovery of sensory (tastant and odorant) G protein-coupled receptors on the smooth muscl

118 neurons might represent a substrate for how odorants gain the quality of tastants.

119 on can explain why plasticity induced by the odorant geranyl acetate (which is attractive) shows no C

120 an odor, which are nearly always mixtures of odorants, give rise to parts of the pattern.

121 while simultaneously inhibiting methane and odorant (H(2)S and VOC) emissions.

122 ificant decrease of the representative green odorants (i.e., hexanal, (E)-2-nonenal, (E,E)-2,4-decadi

123 logical testing of three prolonged-activator odorants identified originally in Aedes aegypti also sho

124 Contextual odorant identity (is the odorant rewarded?) can be decod

125 We model odorant identity and concentration using an odorant-rece

126 In bed bugs, both the odorant identity and concentrations play important roles

127 on for understanding the neural code of both odorant identity and odorant concentration and advances

128 to also respond sensitively to a variety of odorants in Aedes aegypti.

129 neural representations of chemically related odorants in females compared to males during stimulus pr

130 of the harvesting date on concentrations of odorants in Moristel wines of two vintages.

131 tributed, analogous to the representation of odorants in piriform cortex.

132 ve of this study was to identify the primary odorants in rice protein slurries using static headspace

133 model in which many sensilla can respond to odorants in the absence of Obps, and many Obps are not e

134 enable the detection of thousands of unique odorants in the environment and consequently play a crit

135 ition of these nanoparticles to a mixture of odorants, including ethyl butyrate, eugenol, and carvone

136 ane lactones constitute a family of powerful odorants, including the isomers of mintlactone and menth

137 to transform the spatial information of the odorant into the asymmetry between the axonal activities

138 combines 21 physicochemical features of the odorants into a single number-expressed in radians-that

139 actory sensory neurons (OSNs) that transduce odorants into neural electrical signals.

140 Much of receptor sensitivity to odorants is accounted for by a single geometrical proper

141 now reveals that inhibition of receptors by odorants is comparably prevalent and combinatorial.

142 ed peripheral processing of a broad range of odorants is occurring in the main olfactory bulb of the

143 s, CO(2), sex and alarm pheromones, or other odorants known to attract or repel tsetse.

144 Experimentally, increased exposure to odorants leads variously, but reproducibly, to increased

145 s in insects are triggered by the binding of odorant ligands to the variable subunits of heteromeric

146 imary human keratinocytes in the presence of odorant ligands.

147 on of M71 odorant (Ace-responsive) and MOR23 odorant (Lyral-responsive) receptor-expressing cell popu

148 essing of semiochemicals peripherally, these odorants may be processed in a more nuanced and combinat

149 hiol is a critical component of a simplified odorant mixture designed to mimic cigarette smoke odor.

150 s normalization of OSN ensemble responses to odorant mixtures is the rule rather than the exception.

151 model is competitive binding (CB): Only one odorant molecule can attach to a receptor binding site a

152 response to the interaction of a particular odorant molecule with many different olfactory receptors

153 oteins are believed to transport hydrophobic odorant molecules across the aqueous lymph present in an

154 Odorant molecules are detected through the combinatorial

155 Olfaction is mediated by the binding of odorant molecules to olfactory receptors (ORs).

156 rank probable activity of a library of 1280 odorant molecules.

157 rface and selectively and sensitively detect odorant molecules.

158 ultiple environmental cues, including light, odorants, morphogens, growth factors, and contact with c

159 of either sex identify 1-pentanethiol as the odorant most critical for perception of the artificial m

160 olfactometric profiles of the ice ciders, 23 odorants not previously found in Spanish still ciders, a

161 2-Furfurylthiol, a key odorant of coffee, was at the same level in SD and HP co

162 In the present study, key odorants of medium (MRC) and dark roasted Turkish coffee

163 solvent extracts revealed the presence of 76 odorants of which 75 were successfully identified.

164 ized the effects of a wide range of volatile odorants on the contractile state of airway smooth muscl

165 reliably detectable when sampling simulated odorants on the order of seconds, and provides the most

166 ther exclusively to tastants, exclusively to odorants, or to both (bimodal).

167 perceptual similarity between multicomponent odorant pairs.

168 in vitro OR function correlated with in vivo odorant perception using a functional assay.

169 ictive model that links odorant structure to odorant perception(3).

170 OR was frequently associated with changes in odorant perception, and we validated 10 cases in which i

171 We demonstrate striking functions of Orco in odorant perception, reproductive physiology, and social

172 sults also reveal that sub- or perithreshold odorants play outstanding roles on the overall odour int

173 Their volatile compounds with odorant power coming from the distillate and from the wo

174 e from both sexes, and found that in females odorant presentation evoked more rapid OSN signaling ove

175 However, AON activation during odorant presentation reliably suppressed behavioral odor

176 ys, in response to acetophenone and eugenol, odorants previously identified as potential ligands for

177 action by decreasing the amount of volatile odorants reaching ORNs.

178 gests this gene family may underlie the keen odorant reception of chondrichthyans.

179 urbation of OSN function via knockout of the odorant receptor (OR) co-receptor, Orco, results in dras

180 tects myriad volatile chemicals using >1,000 odorant receptor (OR) genes, which are organized into tw

181 istry coincides with rapid divergence in few odorant receptor (OR) genes.

182 of the C. elegans amphid apparatus serve as odorant receptor cells and regulate neuronal output and

183 odorant receptors (ORs) contain a conserved odorant receptor co-receptor (Orco) subunit which is an

184 (DEET) and IR3535 did not activate Anopheles odorant receptor co-receptor (Orco)-expressing olfactory

185 In vivo, the odorant receptor coreceptor (Orco) is an obligatory comp

186 and characterized several antagonists of the odorant receptor coreceptor of the African malaria vecto

187 insights concerning the molecular aspects of odorant receptor function.

188 odor binding to ORco, the common subunit of odorant receptor heteromers, may allosterically alter ol

189 Odorant receptor neurons (ORNs) express specific odorant

190 mentalization of Ca(2+) signals dictates the odorant receptor OR2W3-induced ASM relaxation and identi

191 This chemosensory odorant receptor response was not mediated by adenylyl c

192 ionary conservation of an important class of odorant receptor.

193 odorant identity and concentration using an odorant-receptor binding rate tensor, modulated by the o

194 by the odorant concentration profile, and an odorant-receptor dissociation rate tensor, and quantitat

195 ew experiments for massively identifying the odorant-receptor dissociation rates of relevance to flie

196 issociation rate is only available for a few odorant-receptor pairs.

197 enable the estimation of the affinity of the odorant-receptor pairs.

198 trates that the currently available data for odorant-receptor responses only enable the estimation of

199 such as H. saltator, the 9-exon subfamily of odorant receptors (HsOrs) responds to CHCs, and ectopic

200 nts evolved via expansions in the numbers of odorant receptors (ORs) and antennal lobe glomeruli.

201 The insect chemosensory repertoires of Odorant Receptors (ORs) and Gustatory Receptors (GRs) to

202 ncoded by large gene families, including the odorant receptors (ORs) and the variant ionotropic recep

203 Insect odorant receptors (ORs) are believed to be a complex of

204 ble odorant specificity subunits, all insect odorant receptors (ORs) contain a conserved odorant rece

205 ant receptor neurons (ORNs) express specific odorant receptors (ORs) encoded by a dramatically expand

206 es of volatile components, competing to bind odorant receptors (ORs) expressed in olfactory sensory n

207 erisation of the near-complete repertoire of odorant receptors (Ors) expressed in this tissue, to fra

208 of information about the structure of insect odorant receptors (ORs) hinders the development of more

209 hemosensory proteins (CSPs) and 53 candidate odorant receptors (ORs) using a newly generated whole-ge

210 an obligatory component for the function of odorant receptors (ORs), a major receptor family involve

211 s of a critical class of chemoreceptors, the odorant receptors (ORs), from the ponerine ant Harpegnat

212 sting of distinct patterns of responses from odorant receptors (ORs), trace-amine associated receptor

213 ly of Aedes aegypti olfactory receptors, the odorant receptors (ORs), was not sufficient to reduce ho

214 The odorant receptors (OrXs) Or10a, Or22a, and Or71a from th

215 the first step towards using purified insect odorant receptors alone in biosensors to enable the deve

216 pattern shown to include responses from both odorant receptors and trace-amine associated receptors,

217 SNs expressing about 1000 different types of odorant receptors are precisely organized and sorted out

218 ave enhanced representation for M71 or MOR23 odorant receptors in the olfactory system, as is observe

219 t, and can amplify odorant signaling through odorant receptors in vitro However, the functional signi

220 e mechanisms underlying regulation of insect odorant receptors in vivoSIGNIFICANCE STATEMENT We have

221 Chemoreception, mediated by the odorant receptors on the membrane of olfactory sensory n

222 Herein, we present that insect odorant receptors reconstituted into the lipid bilayers

223 Yet many odorant receptors remain only partially characterized, a

224 Odorant receptors signal through the olfactory-specific

225 s by reducing the constitutive activities of odorant receptors, inhibiting the basal spike firing in

226 has been conducted to characterize different odorant receptors, neuroanatomy and odorant response pro

227 cessing in the downstream neuropils, such as odorant recognition and olfactory associative learning.

228 compared with tufted cells (TCs), leading to odorant representations that were more distinct after re

229 itantly implies an increase in the amount of odorant required to keep the intensity of the aroma vect

230 c OR enrichment and distinctive OR subfamily odorant response profiles, our findings suggest that whe

231 ifferent odorant receptors, neuroanatomy and odorant response properties of the early olfactory syste

232 x circumvents these problems and renders the odorant response robust and reliable.

233 the small space of olfactory cilia during an odorant response.

234 [Formula: see text] concentration during an odorant response.

235 2-tert-butyl-6-methylphenol (BMP) inhibited odorant responses in electroantennogram and single sensi

236 The enhancement of the odorant responses induced by the endogenous zinc nanopar

237 Importantly, MLIs switched odorant responses when the valence of the stimuli was re

238 occurs together with the growth of specific, odorant-responsive glomeruli in the antennal lobe.

239 Here we demonstrate that odorant responsiveness and OR transport is regulated by

240 pplied at ratios measured in larval and male odorants resulted in the discrimination observed between

241 w that olfactory stimulation with particular odorants results in modulation of dozens of OSN subtypes

242 The semi-quantification of key odorants revealed a significant decrease of the represen

243 Contextual odorant identity (is the odorant rewarded?) can be decoded from peak PRP in anima

244 spiration (sniffing) is a hallmark of active odorant sampling by mammals; however, the adaptive funct

245 We found that repeated odorant sampling differentially affected responses in MC

246 To test the impact of repeated odorant sampling on MTC responses, we used two-photon im

247 several seconds; the impact of such repeated odorant sampling on odor representations remains unclear

248 homimetic allele, Orco(S289D) , has enhanced odorant sensitivity compared with wild-type controls.

249 sphorylate this position, have low intrinsic odorant sensitivity that is independent of altered expre

250 rant exposure with concomitant modulation of odorant sensitivity.

251 s obtained for ten chemical families and ten odorant series visualize the changes for each condition.

252 olfactory Galphaolf subunit, and can amplify odorant signaling through odorant receptors in vitro How

253 tegrate signals reflecting a wide variety of odorants.SIGNIFICANCE STATEMENT Inhibitory circuits in t

254 ion to optimize discrimination of particular odorants.SIGNIFICANCE STATEMENT Lateral inhibition is a

255 In other words, why do some odorants smell like fruits and others like flowers?

256 r740 gene family with ~800 perfumery-related odorants spanning a range of chemical scaffolds and func

257 potentially impart evolutionarily adaptive, odorant-specific features to behavioral plasticity.SIGNI

258 tion patterns, SACs are capable of mediating odorant-specific patterns of inhibition between glomerul

259 In addition to variable odorant specificity subunits, all insect odorant recepto

260 RNA-transfected keratinocytes in response to odorant stimulation with acetophenone and eugenol was as

261 on of skin-induced chemosensory responses to odorant stimulation, which might modulate differential n

262 Removal of the odorant stimulus only during the critical period leads t

263 data to refine a predictive model that links odorant structure to odorant perception(3).

264 A group 123 components, including key-odorants, technological and botanical tracers, were mapp

265 physiological and behavioral response to an odorant that affects oviposition.

266 ding both cuticular hydrocarbons and general odorants that are likely to mediate distinct behaviors.

267 The identification of a suite of natural odorants that can be used to modify the CO(2)-detection

268 y, the high sensitivity for the detection of odorants that contain benzene rings.

269 -off in the measure: pairs of multicomponent odorants that were within 0.05 radians of each other or

270 As the animal learns to discriminate the odorants the dimensionality of PRP decreases.

271 man odour, reveals a subset of salient human odorants to be detected by Ors at physiological relevant

272 eening and machine learning, we selected 214 odorants to characterise the response of MOR18-2 and its

273 By applying male odorants to females to increase resident male aggressive

274 esponses of the interneurons to the training odorants to generate learned olfactory behavior.

275 By contrast, the rules for mixing odorants to make a target odor remain elusive.

276 believed essential for carrying hydrophobic odorants to odor receptors.

277 iption factors, constraining emission of the odorants to sporulating colonies.

278 aldehyde, as well as lipid oxidation derived odorants to the overall odor of rice proteins.

279 ponses to mixtures of up to 12 monomolecular odorants to within 15% of experimental observations and

280 fruit fly OSNs as a cascade consisting of an odorant transduction process (OTP) and a biophysical spi

281 remain only partially characterized, and the odorant transduction process and the axon hillock spikin

282 Detailed molecular models of the odorant transduction process are, however, scarce for fr

283 of the space of odorants, are encoded by the odorant transduction process.

284 Compared to H(2)O and a novel odorant, vanilla, mice exposed to TMT in the home cage s

285 ach ORN scales with the concentration of any odorant via a fixed dose-response function with a variab

286 the responses of olfactory sensilla to these odorants was examined as well.

287 Concentrations of 30 important odorants were compared for SD, HP (50 degrees C) and TD

288 Twenty-seven odorants were detected by GC-O.

289 A total of 26 and 28 key odorants were detected in the MRC and DRC samples, respe

290 a extract dilution analysis (AEDA), nineteen odorants were detected.

291 The key odorants were ethyl propionate, ethyl octanoate, propano

292 tive neurons does not affect the response to odorants, whereas fusion between chemoattractive and che

293 a repulsive sensory response to the training odorants, which together decouple the responses of the i

294 es Reserva (MRE) had 'buttery-lactic' impact odorants, while 'empyreumatic' and 'sweet' aromas stood

295 higher percentage of 'grassy-vegetal' impact odorants, while 'spicy' compounds highlighted the Pedro

296 h ask subjects to discriminate monomolecular odorants whose difference in odor cannot be quantified.

297 The results showed that aldehydes were the odorants with the highest aromatic impact in starch-base

298 g the first olfactory relay are inhibited by odorants (Zhang and Gaudry, 2016).

299 ified a fragrant lactone corresponding to an odorant zone reminiscent of coconut and dried figs as 5,

300 he presence of those lactones to interesting odorant zones, reminiscent of mint, detected in the stud