ライフサイエンスコーパス: olfactory receptor

1 lelic neural genes (e.g., protocadherins and olfactory receptors).

2 byx mori enhanced the sensitivity of a mouse olfactory receptor.

3 mixtures are discriminated by relatively few olfactory receptors.

4 nsive rule in odorant detection by mammalian olfactory receptors.

5 somal genes were annotated, 22 of which were olfactory receptors.

6 ression and ligand-induced responses of some olfactory receptors.

7 ck by ablating or odorant targeting mosquito olfactory receptors.

8 ands to the variable subunits of heteromeric olfactory receptors.

9 epends on the selectivity and sensitivity of olfactory receptors.

10 presentation of odorants at the level of the olfactory receptors.

11 urons that did not receive direct input from olfactory receptors.

12 hange is in part driven by the expression of olfactory receptors.

13 man trace amine-associated receptor, and two olfactory receptors.

14 itionally, we detailed the expression of 140 olfactory receptors.

15 ionotropic receptor (IR) family of putative olfactory receptors.

16 of the combined response of several hundred olfactory receptors.

17 ticular odorant molecule with many different olfactory receptors.

18 factory sensory neurons expressing different olfactory receptors.

19 elements of biological smell systems are the olfactory receptors.

20 Mouse olfactory receptor 23 (MOR23, olfr16) and its human orth

21 ure up-regulated HBD-3 and LL-37 through the olfactory receptor 2AT4 and induced phosphorylation of e

22 This response requires olfactory receptor activity and the Notch ligand Delta.

23 It is also subject to regulatory inputs from olfactory receptor activity in other ORNs.

24 Frameshift (FS) indels are enriched in olfactory receptor activity while non-frameshift (NFS) i

25 isms with both developmentally hardwired and olfactory receptor activity-dependent components that es

26 y unobserved pathways, including non-sensory olfactory receptor activity.

27 7 candidate genes significantly clustered in olfactory receptors activity (GO:0004984, p = 4 x 10(- 1

28 h PME and valeric acid traits, as well as 17 olfactory receptors activity genes for PME traits relate

29 methylase activity in activation of a single olfactory receptor allele and suppression of the rest of

30 factory bulb (dOB) innervated by the MOR18-2 olfactory receptor, also known as Olfr78, with human ort

31 ynaptic refinement requires the OSN-specific olfactory receptor and downstream activity.

32 produced by predators that activates a mouse olfactory receptor and produces an innate behavioral res

33 lfactory neuron will usually select a single olfactory receptor and repress remaining members of larg

34 s, but also constrains relationships between olfactory receptors and behavior.

35 sensory neurons that express highly related olfactory receptors and display similar central projecti

36 fluctuation, building on the linkage between olfactory receptors and HLA, we hypothesized that olfact

37 In contrast to mammalian and Drosophila olfactory receptors and mammalian taste receptors, which

38 bility to enhance heterologous expression of olfactory receptors and other difficult to express G pro

39 ounds present in the food that interact with olfactory receptors and produce a perceptual response in

40 ny implausible genes (such as those encoding olfactory receptors and the muscle protein titin), sugge

41 in part due to poor functional expression of olfactory receptors and/or limited solubility of some od

42 The olfactory receptors are employed as a biological element

43 Olfactory receptors are G protein-coupled receptors that

44 Our evidence suggests a model in which olfactory receptors are regulated epigenetically and the

45 The identification of the olfactory receptors as the largest family of GPCRs catap

46 We identify 814 associated loci, including olfactory receptor associations with fruit and tea intak

47 e detected within genomic regions containing olfactory receptor, ATP-binding cassette, and major hist

48 e glial cells disappears after the period of olfactory receptor axon ingrowth, but may be important d

49 revious attempts at constructing a mammalian olfactory receptor-based artificial odorant sensing syst

50 ntial in the future development of practical olfactory receptor-based odorant sensors.

51 However, no ligands for fish olfactory receptor class A related genes (ORA) had been

52 lar structures where afferents from a single olfactory receptor class synapse with uniglomerular proj

53 , which first contribute to the formation of olfactory receptor compartments and then form a multi-ch

54 DB1 regulate the assembly and maintenance of olfactory receptor compartments, Greek island hubs and o

55 genome-wide introgression signatures include olfactory receptor complexes into both species, hyperten

56 Olfactory receptors composed 47% of CN differentiated ge

57 aracterisation of the gene family coding the olfactory receptors contributed to the elaboration and d

58 ition was due to efficient blocking of Orco (olfactory receptor coreceptor) function.

59 ignificant position is the Arginine from the Olfactory receptor "DRY" motif, which has more variants

60 hese contacts are orchestrated by intergenic olfactory receptor enhancers, the 'Greek islands', which

61 We find that Olfr78, an olfactory receptor expressed in the kidney, responds to

62 thermophoresis measurements showed that one olfactory receptor expressed using peptide surfactants b

63 can confer sensitive and robust responses of olfactory receptors expressed in yeast.

64 ns, in improving odor-mediated activation of olfactory receptors expressed in yeast.

65 Moreover, Tet3 overexpression disrupts olfactory receptor expression and the targeting of axons

66 d transcription factor (Acj6) only regulates olfactory receptor expression in one ORN type and only w

67 urons (OSNs) at an immature state and alters olfactory receptor expression, but the mechanism remains

68 folded protein response in the regulation of olfactory receptor expression, unveiling molecular playe

69 Mammalian olfactory receptor families are segregated into differen

70 This olfactory receptor family member is required for HCMV at

71 protein-coupled receptors, particularly, the olfactory receptor family, and inhibiting the transcript

72 ctory system, with its hundreds of different olfactory receptors, far outperforms the other senses in

73 The identification of a sensitive zebrafish olfactory receptor for these diamines provides a molecul

74 Overall HLOF genes are enriched for olfactory receptor function and are expressed in testes

75 eceptor heteromers, may allosterically alter olfactory receptor function and profoundly affect subseq

76 This assembly reveals the duplication of an olfactory receptor gene (OR3), which we demonstrate enha

77 he stabilization and establishment of single olfactory receptor gene choice.

78 ory neurons and their progenitors shows that olfactory receptor gene clusters from 18 chromosomes mak

79 h and 94.7% DNA sequence identity located in olfactory receptor gene clusters, indicating nonallelic

80 Olfactory receptor gene families are significantly expan

81 a tentative assignment of odor responses to olfactory receptor gene families.

82 The insect olfactory receptor gene family is absent from S. maritim

83 ated ora genes are a small, highly conserved olfactory receptor gene family of only six genes, whose

84 or allele and suppression of the rest of the olfactory receptor gene family, thereby locking in the e

85 Here we show that the olfactory receptor gene Olfr78 is highly and selectively

86 d deleterious missense common variant in the olfactory receptor gene OR2AG2 that segregated with a ri

87 ancer that associates with the single active olfactory receptor gene.

88 set of 166 dispensable genes was enriched in olfactory receptor genes (41 genes).

89 We found that orthologs for both classes of olfactory receptor genes (mORs and Oras) appear to be hi

90 he placenta also expressed most of the known olfactory receptor genes (Olfr), which may allow the pla

91 ted by heterozygosity hotspots, enriched for olfactory receptor genes and other genes with high level

92 We focused on the expression profiles of olfactory receptor genes and transcription factors-the t

93 obin gene expression whereas silent flanking olfactory receptor genes are unaffected.

94 -redundant fashion, and that individual main olfactory receptor genes can contribute substantially to

95 The 41 dispensable olfactory receptor genes displayed a relaxation of selec

96 ptation in the functional diversification of olfactory receptor genes in a bird lineage that relies e

97 sh v2r genes are intermingled with all other olfactory receptor genes in a single sensory surface.

98 We also found extensive expansion of olfactory receptor genes in these turtles.

99 Olfactory receptor genes, upstream effectors of the MAPK

100 However, we found very few olfactory receptor genes, very few trace amine-associate

101 34B7.4 gene, a novel antisense gene to three olfactory receptor genes.

102 is implicated in rodenticide resistance, and olfactory receptor genes.

103 nstraints similar to that observed for other olfactory receptor genes.

104 positive selection acting on paralogous main olfactory receptor genes.

105 ompassing the beta-globin locus and flanking olfactory receptor genes.

106 alternative solution for amine detection by olfactory receptors highlights the tremendous structural

107 ional analysis indicates roles for different olfactory receptors in long- and short-range attraction

108 cient transport of food volatiles toward the olfactory receptors in the nasal cavity.

109 oked activity and reversible inactivation of olfactory receptors in the nasal epithelium significantl

110 te olfactory system, which requires that new olfactory receptors integrate into segregated and functi

111 genitor cell transplant, such that a ventral olfactory receptor is expressed after stem and progenito

112 r, which is due to the fact that each of the olfactory receptors is coded with different gene and usu

113 This remodeling does not result from olfactory receptor loss or OSN degeneration, but rather

114 Our study suggests that OR2AG2 and other olfactory receptors may contribute to asthma pathophysio

115 t - unlike in Drosophila and as in mammals - olfactory receptors may play a role, providing new insig

116 e nucleotide identities for orthologous main olfactory receptor (mOR) genes with nucleotide identitie

117 n electron microscopy to reconstruct all the olfactory receptor neuron (ORN) axons that target a left

118 mbly of the Drosophila olfactory circuit, 50 olfactory receptor neuron (ORN) classes and 50 projectio

119 Odors typically activate multiple olfactory receptor neuron (ORN) classes and are therefor

120 hila olfactory circuit assembly, axons of 50 olfactory receptor neuron (ORN) classes and dendrites of

121 Drosophila uses 50 different olfactory receptor neuron (ORN) classes that are cluster

122 secreted semaphorin, Sema-2b, in Drosophila olfactory receptor neuron (ORN) development, we identifi

123 transcription factor combinations specifying olfactory receptor neuron (ORN) fates.

124 zation scales with the total activity of the olfactory receptor neuron (ORN) population.

125 odor representations in vivo by imaging from olfactory receptor neuron (ORN) terminals during control

126 One notable exception is the vertebrate olfactory receptor neuron (ORN), where the transduction

127 ach receiving input from a different type of olfactory receptor neuron (ORN).

128 e report here the signaling threshold of the olfactory receptor neuron (ORN).

129 As flies explore a circular arena, their olfactory receptor neuron (ORNs) are optogenetically act

130 to an inhibitory chemical synapse between an olfactory receptor neuron and an interneuron changed the

131 2 is unable to protect transected Drosophila olfactory receptor neuron axons in vivo, mutant Nmnat2s

132 it seems to be a common feature of amphibian olfactory receptor neuron axons to frequently bifurcate

133 sparse cell electroporation to trace single olfactory receptor neuron axons.

134 pil that contain input and output processes: olfactory receptor neuron nerve terminals (input) and mi

135 Little is known about how an olfactory receptor neuron selects a receptor, or how the

136 l number are selected for expression by each olfactory receptor neuron.

137 We show that a bursting subset of primary olfactory receptor neurons (bORNs) in lobster has the un

138 lations of rhythmically active or 'bursting' olfactory receptor neurons (bORNs) to extract and encode

139 Olfactory receptor neurons (ORNs) 'A' and 'B' in the tri

140 ample is the olfactory system, as individual olfactory receptor neurons (ORNs) adopt unique sensory i

141 synaptic-depression at the synapses between olfactory receptor neurons (ORNs) and neurons within the

142 SDns received glomerulus-specific input from olfactory receptor neurons (ORNs) and projection neurons

143 ion to a limited set of neurons that include olfactory receptor neurons (ORNs) and the mushroom body

144 Vertebrate olfactory receptor neurons (ORNs) are stimulated in a rh

145 orant receptor co-receptor (Orco)-expressing olfactory receptor neurons (ORNs) at any concentration,

146 re we show that compartmentalized Drosophila olfactory receptor neurons (ORNs) communicate with each

147 pulses and steps, but it remains unclear how olfactory receptor neurons (ORNs) detect the intensity a

148 hat calcium signals in the axon terminals of olfactory receptor neurons (ORNs) do not follow the same

149 orur-Shandilya et al., 2017) that Drosophila olfactory receptor neurons (ORNs) expressing the co-rece

150 hat Psidin is required in several classes of olfactory receptor neurons (ORNs) for survival and subse

151 ophila, axons of approximately 50 classes of olfactory receptor neurons (ORNs) form one-to-one connec

152 This study shows that olfactory receptor neurons (ORNs) function upstream of a

153 he Drosophila antenna, different subtypes of olfactory receptor neurons (ORNs) housed in the same sen

154 a, we show that Notch is activated in select olfactory receptor neurons (ORNs) in an odorant-specific

155 tegration of olfactory information begins in olfactory receptor neurons (ORNs) in Drosophila.

156 ypes of olfactory sensilla, which harbor the olfactory receptor neurons (ORNs) in the Drosophila ante

157 Olfactory receptor neurons (ORNs) in the nasal cavity de

158 hamsters and that induction of apoptosis in olfactory receptor neurons (ORNs) in the OSE resulted in

159 to bombykol and is expressed in specialized olfactory receptor neurons (ORNs) in the pheromone sensi

160 ensory identities of Drosophila melanogaster olfactory receptor neurons (ORNs) involved in sex-specif

161 Olfactory transduction in vertebrate olfactory receptor neurons (ORNs) involves primarily a c

162 e Drosophila olfactory system, 50 classes of olfactory receptor neurons (ORNs) make precise synaptic

163 roup housing increases the response of Or47b olfactory receptor neurons (ORNs) only in mature males.

164 Olfactory receptor neurons (ORNs) produce a constant syn

165 In Drosophila, most individual olfactory receptor neurons (ORNs) project bilaterally to

166 The Drosophila olfactory receptor neurons (ORNs) provide an excellent s

167 originates almost entirely from the primary olfactory receptor neurons (ORNs) rather than from spont

168 a supported, in part, by the assumption that olfactory receptor neurons (ORNs) respond to odorants wi

169 Individual olfactory receptor neurons (ORNs) selectively express on

170 t studies have identified a subpopulation of olfactory receptor neurons (ORNs) that consist of intrin

171 The basis for host odor responses resides in olfactory receptor neurons (ORNs) that express chemorece

172 The responses of olfactory receptor neurons (ORNs) to odors have complex

173 he FEZF1 product is known to enable axons of olfactory receptor neurons (ORNs) to penetrate the CNS b

174 information about odors is transferred from olfactory receptor neurons (ORNs) to projection neurons

175 Olfactory receptor neurons (ORNs) transform scant chemic

176 otonin indirectly inhibits odor responses in olfactory receptor neurons (ORNs) via GABAergic local in

177 How the activity patterns of primary olfactory receptor neurons (ORNs), at the individual and

178 and odorant receptors expressed in different olfactory receptor neurons (ORNs), but the origin of tem

179 In Drosophila olfactory receptor neurons (ORNs), DEET is detected thro

180 inding to membrane receptors on the cilia of olfactory receptor neurons (ORNs), thereby activating a

181 eactive processes relative to each other, to olfactory receptor neurons (ORNs), to projection neurons

182 pond to odors depends on the function of its olfactory receptor neurons (ORNs), which in turn depends

183 iating inhibitory odorant input to mammalian olfactory receptor neurons (ORNs).

184 s from their presynaptic partners, the adult olfactory receptor neurons (ORNs).

185 g in patterning axon targeting of Drosophila olfactory receptor neurons (ORNs).

186 elated with changes in the firing pattern of olfactory receptor neurons (ORNs).

187 how these ionotropic inputs are amplified in olfactory receptor neurons (ORNs).

188 blem: on the basis of noisy information from olfactory receptor neurons (the neurons that transduce c

189 The functional synaptic connectivity between olfactory receptor neurons and principal cells within th

190 a we have confirmed the connectivity between olfactory receptor neurons and their postsynaptic target

191 st two layers of this system: the peripheral olfactory receptor neurons and their postsynaptic target

192 d to the kinetics of odor tracking in insect olfactory receptor neurons and to the latency of initial

193 ion times and pulse tracking capabilities of olfactory receptor neurons are faster than previously re

194 lar increases in sleep are not observed when olfactory receptor neurons are silenced or when other se

195 erties of presynaptic glutamate release from olfactory receptor neurons are similar between mitral an

196 amily ligand GDF11, regulates the genesis of olfactory receptor neurons by inhibiting proliferation o

197 Thus, insect olfactory receptor neurons can track stimuli of very sho

198 ly, LN innervation required interaction with olfactory receptor neurons during development, and some

199 ction, and we find that a specific subset of olfactory receptor neurons encodes absolute salinity con

200 In the mouse, each class of olfactory receptor neurons expressing a given odorant re

201 ansgenic lines of Anopheles gambiae in which olfactory receptor neurons expressing the odorant recept

202 Olfactory receptor neurons extend axons into the olfacto

203 cortex explaining incoming activity from the olfactory receptor neurons in terms of a mixture of odor

204 Although olfactory receptor neurons in the nose face similar stim

205 histochemistry revealed segregation of CR-ir olfactory receptor neurons in the olfactory mucosa and t

206 In the olfactory bulb, afferent olfactory receptor neurons respond to increasing concent

207 em has a three-layer architecture: The fly's olfactory receptor neurons send odor information to the

208 rganized into glomerular compartments, where olfactory receptor neurons synapse onto projection neuro

209 Primary olfactory receptor neurons terminate in anatomically and

210 times more pore plates and three times more olfactory receptor neurons than females.

211 The response of olfactory receptor neurons to odor mixtures is not well

212 ghwire and c-Jun N-terminal kinase basket in olfactory receptor neurons weaken the sleep-promoting ef

213 etronasal odorants can effectively reach the olfactory receptor neurons, eliciting glomerular respons

214 s have a role in the long-term protection of olfactory receptor neurons, possibly through its antioxi

215 rent odors excite overlapping populations of olfactory receptor neurons, so the central challenge of

216 Odours generate activity in olfactory receptor neurons, whose axons contact the dend

217 ells receive direct, monosynaptic input from olfactory receptor neurons.

218 ir through the nasal cavity to stimulate the olfactory receptor neurons.

219 channel defined by inputs from one class of olfactory receptor neurons.

220 ce expressing the Ca(2+) indicator GCaMP3 in olfactory receptor neurons.

221 ular rind, overlapping with the terminals of olfactory receptor neurons.

222 y of citronellal-evoked action potentials in olfactory receptor neurons.

223 an age-dependent reduction in the number of olfactory receptor neurons.

224 A human taste receptor, hT2R4, and an olfactory receptor of Caenorhabditis elegans (C. elegans

225 Olfactory receptor (Olfr) genes comprise the largest gen

226 OSNs, and promotes the selection of specific olfactory receptor (Olfr) genes for expression in mature

227 A short-chain fatty acid olfactory receptor Olfr78, recently implicated in CB fun

228 The activation of G-protein-coupled olfactory receptors on the olfactory sensory neurons (OS

229 Insect olfactory receptors operate as ligand-gated ion channels

230 ithelium (OE) each express a single dominant olfactory receptor (OR) allele from among roughly 1,000

231 anscriptional activation of one out of ?2800 olfactory receptor (OR) alleles is a poorly understood p

232 The molecular mechanisms regulating olfactory receptor (OR) expression in the mammalian nose

233 Olfactory receptor (OR) expression requires the transcri

234 expresses only one out of up to thousands of olfactory receptor (OR) gene alleles; at the organism le

235 d of 10 million cells and each expresses one olfactory receptor (OR) gene from a pool of over 1000.

236 cular, our results showed contraction of the Olfactory Receptor (OR) gene repertoire in the last comm

237 because of the hierarchical structure of the olfactory receptor (OR) gene superfamily: expansion or c

238 However, OSNs exhibited an interior bias for olfactory receptor (OR) genes and enhancers, in clear co

239 We show that 98.9% of intact olfactory receptor (OR) genes are expressed in mature OS

240 how that, in the mouse olfactory epithelium, olfactory receptor (OR) genes are marked in a highly dyn

241 The olfactory receptor (OR) genes are the largest mammalian

242 how that, in mouse olfactory neurons, silent olfactory receptor (OR) genes from different chromosomes

243 Furthermore, the organization, detection and olfactory receptor (Or) genes of MP-OSNs are conserved i

244 ccording to the identity of the co-expressed olfactory receptor (OR).

245 vate ACIII, presumably through the canonical olfactory receptor (OR).

246 y stage of odorant recognition by the rat I7 olfactory receptor (OR-I7) is investigated.

247 Each ORN type expresses a unique olfactory receptor, or a combination thereof, and sends

248 d gene-sets related with sensory perception (olfactory receptors, OR) and phenylpyruvate tautomerase/

249 ixed, a response mainly due to the conserved olfactory receptor, Or42b.

250 ocarbons was suppressed by a mutation in the olfactory receptor Or47b.

251 propriate ORNs the expression of fru and two olfactory receptors (Or47b and Ir84a) involved in sex-sp

252 While the larval OSN expresses the olfactory receptor Or49a and is tuned to the Leptopilina

253 In this study we detected the olfactory receptor OR51E2 at the transcript and the prot

254 s detected through a mechanism employing the olfactory receptor, OR83b.

255 give rise to three major neuronal classes - olfactory receptor (ORNs), vomeronasal (VRNs) and gonado

256 ic expression of only one out of >1000 mouse olfactory receptor (ORs) genes requires the formation of

257 Ectopic olfactory receptors (ORs) are found in the skin, but the

258 Olfactory receptors (ORs) are G protein-coupled receptor

259 Olfactory receptors (ORs) are G protein-coupled receptor

260 factory system, including those encoding the olfactory receptors (ORs) CpomOR1, CpomOR3 and CpomOR6a,

261 Expression of olfactory receptors (ORs) has been reported in many huma

262 The family of olfactory receptors (ORs) subserves the sense of smell a

263 Humans use a family of more than 400 olfactory receptors (ORs) to detect odors, but there is

264 Olfactory receptors (ORs), encoded by the largest verteb

265 heterologously overexpress and purify insect olfactory receptors (ORs).

266 f chemoreceptors in human keratinocytes, the olfactory receptors (ORs).

267 mmals sense odors through the gene family of olfactory receptors (ORs).

268 iated by the binding of odorant molecules to olfactory receptors (ORs).

269 hereby locking in the expression of a single olfactory receptor per sensory neuron.

270 actory sensory neurons expressing particular olfactory receptors project to specific reproducible loc

271 neurons and the antisymmetric expression of olfactory receptor proteins in the AWC neurons.

272 ing affinity are ejected before reaching the olfactory receptor, rendering them susceptible to degrad

273 the TAARs are evolutionarily retained in the olfactory receptor repertoire to mediate high-sensitivit

274 otential to enable systems level analysis of olfactory receptor repertoires in organisms.

275 TAAR5 is an evolutionarily conserved olfactory receptor required for a species-specific behav

276 to an objective procedure to obtain specific olfactory receptor responses by manipulating mixtures in

277 ct with the PAMs membrane protein OR5M11, an olfactory receptor, resulting in the high-level secretio

278 neering analyses, the study reveals that the olfactory receptor selection system is optimally designe

279 ENT We have uncovered a mechanism underlying olfactory receptor sensitivity regulation in Drosophila

280 nd provide an algorithm for predicting which olfactory receptors should increase or decrease in abund

281 Our findings thus suggest that activation of olfactory receptor signaling by external compounds can i

282 in family, known to contain the chemosensory olfactory receptor subfamily.

283 unique subset of approximately 400 different olfactory receptor subtypes.

284 Furthermore, olfactory receptors that detect cadaverine and putrescin

285 This suggests the olfactory receptors that remain, such as the ionotropic

286 tional ablation of a family of Aedes aegypti olfactory receptors, the odorant receptors (ORs), was no

287 rine olfactory epithelium (OE) differ by the olfactory receptor they express as well as other molecul

288 second mode relies on the signaling from the olfactory receptors through CamK and histone acetyl tran

289 ATEMENT Odor information is transmitted from olfactory receptors to olfactory bulb, and then to pirif

290 They use olfactory receptors to process chemical signals in their

291 rations of cadaverine expresses a particular olfactory receptor, trace amine-associated receptor 13c

292 a mouse chemosignal, trimethylamine, and its olfactory receptor, trace amine-associated receptor 5 (T

293 receptor compartments, Greek island hubs and olfactory receptor transcription, providing mechanistic

294 that each MOR23 neuron has higher levels of olfactory receptor transcripts and also expresses more C

295 wasps of all sizes to have a large number of olfactory receptor types, to maintain olfactory precisio

296 Olfactory receptor usage is highly heterogeneous, with s

297 The function of expressed olfactory receptors was further validated using MDL12330

298 Olfactory receptors, which belong to the family of G-pro

299 genes (centered on p53, topoisomerase 1, and olfactory receptors) whose down-regulation caused the ce

300 at IR8a is a subunit that forms a functional olfactory receptor with IR64a in vivo to mediate odor de