ライフサイエンスコーパス: oligoclonal

1 eactive response may be narrowly focused, or oligoclonal.

2 lpha and beta V regions in the cell line was oligoclonal.

3 ool, CMV-specific CTL remained monoclonal or oligoclonal.

4 accination and in unvaccinated controls were oligoclonal.

5 l integration indicated that the disease was oligoclonal.

6 hat the vascular IgA response in acute KD is oligoclonal.

7 ociated TCRbeta were observed to be commonly oligoclonal.

8 repertoire of Ara h 2-specific antibodies is oligoclonal.

9 The potency of oligoclonal Ab was primarily due to a large increase in

10 tralized toxin, a combination of three mAbs (oligoclonal Ab) neutralized 450,000 50% lethal doses of

11 Both in humans and mice, OS is mediated by oligoclonal activated T and B cells.

12 mmation, with massive tissue infiltration of oligoclonal activated T cells are the hallmark of Omenn

13 nt revealed that protein vaccination induced oligoclonal activation of MAGE-A3-specific CD4+ T cells.

14 B cell response in MCB and showed that it is oligoclonal and directed against an intracellular protei

15 These expanded plasmablasts are oligoclonal and exhibit extensive somatic hypermutation,

16 Whether this oligoclonal and polyclonal IgG is directed against a dis

17 arly CD4(+) T cell response in these mice is oligoclonal and reflects the expansion of Vbeta4/ Valpha

18 a h 2-specific B-cell receptor repertoire is oligoclonal and somatically hypermutated and shares simi

19 f both pathogen-derived Ags and self-Ags are oligoclonal and typically private.

20 and allergen specific, whereas IgE in AR is 'oligoclonal' and allergen specific.

21 olysaccharide Ab responses in mice are often oligoclonal, and the mechanisms involved in Ag-specific

22 These results indicate that oligoclonal aneuploidy and supernumerary centrosomes are

23 al potentials); and intrathecal synthesis of oligoclonal antibody (examination by lumbar puncture of

24 rate inflamed tissues in acute KD, producing oligoclonal, antigen-driven antibodies.

25 a revealed highly dynamic shaping of complex oligoclonal architectures, specifically upon treatment w

26 ccelerated by APRIL; both mouse strains were oligoclonal at 4 months.

27 rtual absence of B cells and the presence of oligoclonal autoreactive T cells.

28 s of rearranged VDJ genes revealed clonal or oligoclonal B cell expansions in all cases.

29 ases, ascites associated with monoclonal and oligoclonal B cell neoplasms.

30 These data suggest an in situ Ag-driven oligoclonal B cell response to a variety of tumor- and b

31 memory to polysaccharide Ags, we studied an oligoclonal B cell response to alpha-1,3 dextran (DEX) e

32 type mice and quasimonoclonal (QM) mice with oligoclonal B cells and TCR Vbeta diversity 7% that of w

33 ild-type values of 1.1 x 10(8); in mice with oligoclonal B cells, the TCR V beta diversity of thymocy

34 Isolated islets contained oligoclonal B lymphocytes enriched for the germinal cent

35 tigen targeted by the dominant clones in the oligoclonal B lymphoplasmacytic response in both patient

36 HCDR3 spectrotype analysis demonstrated oligoclonal B-cell activation and expansion after sepsis

37 These abnormal markers may be produced by oligoclonal B-cell populations or PTLD tumor cells and c

38 The oligoclonal B-cell response in MS cerebrospinal fluid is

39 progenitor cell expansion that evolved into oligoclonal B-lineage ALL in 3% of the transgenic zebraf

40 p to 2-fold differences in the odds of being oligoclonal band positive and 7.75% of the variation in

41 f rs9807334, near the ELAC1/SMAD4 genes, for oligoclonal band status (P = 8.45 x 10(-7)).

42 previously suggested association signals for oligoclonal band status in the major histocompatibility

43 haplotype (P = 1.59 x 10(-22)), shared with oligoclonal band status, and an additional independent e

44 However, the underlying differences between oligoclonal band-positive and -negative patients with mu

45 on polymerase chain reaction testing, and no oligoclonal banding.

46 tries for two traits, presence or absence of oligoclonal bands (n = 3026) and immunoglobulin G index

47 Fifty-five patients (10%) had APB, 48 had oligoclonal bands (OB), and 23 had an apparent isotype s

48 By contrast, the findings of intrathecal oligoclonal bands (OCB) and beneficial effects of steroi

49 bsence of both immunoglobulin (Ig) G and IgM oligoclonal bands (OCB) was blindly examined in paired c

50 ence of cerebrospinal fluid immunoglobulin G oligoclonal bands (OCB; HR = 3.69, 95% CI = 2.32-5.86, p

51 Oligoclonal bands (OCBs) unique to the cerebrospinal flu

52 Four of these subjects had oligoclonal bands (OCBs).

53 For example, the intrathecally synthesized oligoclonal bands (OGBs) in diseases such as subacute sc

54 ation in space, the presence of CSF-specific oligoclonal bands allows a diagnosis of multiple scleros

55 ral nervous system, expressed as presence of oligoclonal bands and/or an increased immunoglobulin G i

56 Studies have shown that these oligoclonal bands are antibodies directed against the ag

57 Increased IgG and oligoclonal bands are found in cerebrospinal fluid of hu

58 More importantly, the major CSF oligoclonal bands from MS patients did not react to C. p

59 amounts of intrathecally synthesized IgG and oligoclonal bands have long been recognized as a hallmar

60 The presence of oligoclonal bands in cerebrospinal fluid (CSF) in multip

61 presence of lipid-specific immunoglobulin M oligoclonal bands in cerebrospinal fluid (CSF; IgM bands

62 in lesions on MR images, and had two or more oligoclonal bands in cerebrospinal fluid.

63 oural change, raised CSF protein and matched oligoclonal bands in CSF and serum was associated with n

64 For example, the intrathecally synthesized oligoclonal bands in diseases such as subacute sclerosin

65 sence of B-cell follicle-like structures and oligoclonal bands in MS patients indicates that certain

66 diagnosis of MS, include the recognition of oligoclonal bands in the cerebrospinal fluid as a possib

67 Of 12 patients who had oligoclonal bands in the cerebrospinal fluid at baseline

68 ectric focusing, we detected SPAG16-specific oligoclonal bands in the cerebrospinal fluid of 5 of 23

69 is the presence of IgG Abs, which appear as oligoclonal bands in the cerebrospinal fluid.

70 mal effect on circulating autoantibodies and oligoclonal bands in the cerebrospinal fluid.

71 There are reports of oligoclonal bands in the CSF of stroke patients, suggest

72 ultiple sclerosis); and cerebrospinal fluid (oligoclonal bands lacking).

73 more likely to have intrathecal synthesis of oligoclonal bands on presentation (64 versus 29%, not si

74 us and inflammatory diseases of known cause, oligoclonal bands represent antibody directed against th

75 CSF oligoclonal bands were found in only one, but bands matc

76 ronal antibodies were present in 43% and CSF oligoclonal bands were present in 46% of patients with p

77 Cerebrospinal fluid (CSF) oligoclonal bands were rare in MOGAD (5/30 (17%)) and AQ

78 with CIS (>/= 2 brain MRI lesions and >/= 2 oligoclonal bands) enrolled in the Observational Study o

79 nt risk factors for MS (spinal cord lesions, oligoclonal bands, and dissemination in time on MRI) and

80 particular sequences that correspond to the oligoclonal bands, and substantial somatic mutation of m

81 at presentation, sex ratio, the presence of oligoclonal bands, clinical symptoms or initial severity

82 cytosis with eosinophils and/or neutrophils, oligoclonal bands, glial fibrillary acidic protein in th

83 have high concentrations of IgG, manifest as oligoclonal bands, in the brain and CSF.

84 Age, positive cerebrospinal fluid for oligoclonal bands, infratentorial lesions on MRI, and sp

85 who only had temporal lobe epilepsy without oligoclonal bands, may represent restriction to the firs

86 Further testing included oligoclonal bands, serum levels of glial fibrillar acidi

87 forts to identify an antigenic target of CSF oligoclonal bands, the presence of idiotope (Id)-bearing

88 s, and the later features with appearance of oligoclonal bands.

89 athecal synthesis of IgG and the presence of oligoclonal bands.

90 obulin G (IgG) synthesis and the presence of oligoclonal bands.

91 oncentration, and three of five examined had oligoclonal bands.

92 al fluid and brain contain increased IgG and oligoclonal bands.

93 normal, <5.9 mg/dL); however, there were no oligoclonal bands.

94 MS are clinically silent MRI lesions and CSF oligoclonal bands; weak or uncertain risk factors includ

95 g the skin biopsies of patients with SSc are oligoclonal, beta-chain TCR transcripts from T cells inf

96 ells in vivo, it has been hard to prove that oligoclonal BV expansions are actually HIV specific.

97 er BMT was concomitant with the detection of oligoclonal CD3(+)CD8(+)CD45RO(+) cells.

98 g of T-cell receptor genes revealed distinct oligoclonal CD4(+) and CD8(+) T-cell repertoires in the

99 her, the results also suggest that the major oligoclonal CD4(+) T cell expansions present in RA joint

100 ized by noncaseating epithelioid granulomas, oligoclonal CD4(+) T cell infiltrates, and immune comple

101 involving T lymphocytes that are composed of oligoclonal CD4+ T cells.

102 petic skin lesions consistently demonstrated oligoclonal CDR3 DNA length distribution, indicating the

103 nt are in-frame until late gestation; 3) the oligoclonal CDR3 spectratype of 30-day fetal liver becom

104 unoglobulin heavy and light chains from each oligoclonal CLL-cell population.

105 We constructed genealogic trees of these oligoclonal CLL-cell subgroups and assessed the effects

106 the T-cell repertoire with the emergence of oligoclonal/clonal lymphoid populations have been found

107 In most patients, multiple monoclonal and oligoclonal complementarity-determining region 3 (CDR3)

108 cytotoxic T-lymphocyte activity, and had an oligoclonal component.

109 he antigen-specific serum immune response is oligoclonal, comprising antibodies encoding 34 different

110 Remarkably, the tumors were frequently oligoclonal, consistent with accelerated genetic changes

111 icity to MPO, 2) the anti-MPO Ab response is oligoclonal, consistent with Ag selection, and 3) MPO is

112 ecificity, we examined the TCR repertoire of oligoclonal CTL expansions found in human blood and tiss

113 l lesions and in atherosclerotic plaques are oligoclonal, derived from few expanding cells.

114 These results suggest a model of 2-step oligoclonal development of male germ cells in mice, the

115 erent samples consistent with multiclonal or oligoclonal disease in a significant proportion of MF pa

116 t acute myeloid leukemia is a highly dynamic oligoclonal disease.

117 Interestingly, monoclonal or oligoclonal dominance was seen in the reactive Vbeta+ ce

118 The VDJ sequences of Vbeta6 chains were oligoclonal during the early stages of the infection, su

119 ptor revision, codon insertion/deletion, and oligoclonal expansion had occurred within the B and plas

120 se T cell receptor Vbeta repertoires with an oligoclonal expansion in CDR3 of T cell receptor Vbeta14

121 autoreactive T-cells that likely arise from oligoclonal expansion in response to autoantigen exposur

122 In contrast to oligoclonal expansion observed in systemic autoimmune di

123 n antigen or infectious agent leading to the oligoclonal expansion of B and T cells is unknown.

124 d by CD8(+) and CD4(+) T cells and exhibited oligoclonal expansion of specific T cell subsets.

125 TCRbeta deep sequencing revealed oligoclonal expansion of specific TCRbeta clonotypes in

126 ed natural killer (NK) cell infiltration and oligoclonal expansion of T cells were detected.

127 Intratumoral oligoclonal expansion of TIL-B was demonstrated by a pre

128 We observed a consistent oligoclonal expansion of Vbeta4(+) T cells during the pe

129 polyclonal TCR pattern, without evidence of oligoclonal expansion, or a preferred usage of certain V

130 genes but not for CD4(+) T cell activation, oligoclonal expansion, or accumulation in the liver.

131 d in some microdissected regions, suggesting oligoclonal expansion.

132 te in CNS lesions of MS patients and display oligoclonal expansion.

133 ewed TCR repertoires, which is indicative of oligoclonal expansion; these skewed repertoires and the

134 bly, these CD5(+) B cell populations include oligoclonal expansions already found in young healthy ad

135 Biliary atresia is associated with oligoclonal expansions of CD4(+) and CD8(+) T cells with

136 In utero CMV infection induced oligoclonal expansions of fetal CD4(+) and CD8(+) T lymp

137 We report massive oligoclonal expansions of intraepithelial CTLs that exhi

138 In addition, oligoclonal expansions of lung T cells have been observe

139 patients with rheumatoid arthritis (RA) have oligoclonal expansions of peripheral blood CD8+ T cells

140 nsplantation, and all patients had transient oligoclonal expansions of T cells expressing specific Vb

141 that chronic cigarette smoke exposure causes oligoclonal expansions of T cells isolated from the lung

142 We found that primary infection elicited oligoclonal expansions of T(H)1-like EBV-specific CD4(+)

143 is injury and determine whether the numerous oligoclonal expansions of this disease represent extreme

144 Moreover, they encompassed oligoclonal expansions paralleling an expansion of effec

145 ne smoking cessation for 6 mo, revealed that oligoclonal expansions persisted.

146 TCR Vbeta repertoire analyses revealed oligoclonal expansions predominantly occurred in lung CD

147 ical spastic paraparesis (HAM/TSP), mono- or oligoclonal expansions were detected in the CD4+ T cell

148 riable (TCRBV) sequencing confirmed that the oligoclonal expansions were largely related to HSV-speci

149 four of five CBD patients studied, different oligoclonal expansions within the Vbeta3 subset were fou

150 acultative help for autoantibody production, oligoclonal expansions, and proliferations driven by an

151 o 66 (M158-66), which simultaneously lead to oligoclonal expansions, including the usage of a single

152 ased with LCMV epitope-specific T cells with oligoclonal expansions.

153 at p53 knockout thymic lymphomas arose in an oligoclonal fashion, with tumors evolving dominant clone

154 toires are diverse and others restricted or "oligoclonal" has been unknown.

155 ged and young hematopoietic clones confirmed oligoclonal hematopoiesis and revealed mutations in at l

156 Furthermore, exome sequencing revealed that oligoclonal hematopoiesis emerged in Casp9-deficient bon

157 of AML cases demonstrated residual aberrant oligoclonal hematopoiesis.

158 ponses to immunodominant viral antigens were oligoclonal, highly skewed, and exhibited diverse clonot

159 Oligoclonal Ig bands (OCBs) of the cerebrospinal fluid a

160 uction by the malignant plasma cell clone or oligoclonal Ig production during recovery of B-cell func

161 These findings, and the fact that the oligoclonal IgA and IgM repertoires in a noninductive si

162 Previously, we showed that oligoclonal IgA plasma cells infiltrate coronary arterie

163 Molecular analysis of the oligoclonal IgA response in acute KD led to production o

164 The identification of an oligoclonal IgA response in KD strongly suggests that th

165 ions (>3 vertebral segments), and absence of oligoclonal IgG bands .

166 Oligoclonal IgG bands are rarely found in patients with

167 date infectious antigens, we showed that the oligoclonal IgG in cerebrospinal fluid of a patient with

168 ervous system infections have shown that the oligoclonal IgG is antibody directed against the agent t

169 hecal IgG synthesis, persistence of bands of oligoclonal IgG, and memory B-cell clonal expansion are

170 se in identifying and purifying the relevant oligoclonal IgGs in inflammatory central nervous system

171 t clonality by immunofluorescence supporting oligoclonal immune responses, the presence of deposit su

172 We have previously reported that oligoclonal immunoglobulin A plasma cells infiltrate acu

173 mphocytes (7-32), elevated protein, multiple oligoclonal immunoglobulin bands, and CRMP-5-IgG.

174 ting the rheumatoid arthritis (RA) joint are oligoclonal, implicating an Ag-driven process, but the p

175 ining usage did not appear to be random, but oligoclonal in nature, with some preference shown for T

176 that although the response in each donor was oligoclonal in terms of variable gene usage, the combina

177 In contrast, oligoclonal innate lymphocyte populations are efficientl

178 opulation, leaving an expanded population of oligoclonal, intermediate affinity (and residual high af

179 persistence and expansion of a population of oligoclonal, intermediate affinity T cells is involved i

180 present for several years in AIE-associated, oligoclonal, intestinal T-cell infiltrate.

181 nses to serovar Typhi in Ty21a vaccinees are oligoclonal, involving multiple TCR Vbeta families.

182 ntigens important in the pathogenesis of KD, oligoclonal KD antibodies were prepared in vitro and tes

183 ifying combination therapies tailored to the oligoclonal landscape of heterogenous tumors.

184 Adoptive transfers of the oligoclonal lines into either C3H x Rag-/- or severe com

185 Monoclonal line PD-F4 and oligoclonal lines ND-R4 and TD-B4 were CD3(+)CD4(+)CD8(-

186 Nine CTL clones and two oligoclonal lines obtained from three unrelated individu

187 nor histocompatibility antigens, we detected oligoclonal liver Vbeta2(+) T cells in 40% of GVHD mice

188 CD4(+)CD28(null) T cells are oligoclonal lymphocytes rarely found in healthy individu

189 naive T cells, their partial replacement by oligoclonal memory populations, and the consequent const

190 (-)CD57(+)), highly proliferative (Ki67(+)), oligoclonal, memory-like CD4 and CD8 T cells (CCR7(-)CD4

191 ke the WT EBV tumors, Delta3A lymphomas were oligoclonal/monoclonal, with typically one dominant IGHV

192 vealed that all of the independently derived oligoclonal mouse tumors had a deletion in the Pten gene

193 FLT3-ITDs induced an oligoclonal myeloproliferative disorder in mice, charact

194 The findings also demonstrate the oligoclonal nature of retrovirus-induced lymphomas by de

195 Oligoclonal, NF-containing bursas lacked detectable c-my

196 Vbeta subsets from CD8-positive cells showed oligoclonal or monoclonal CDR3 size patterns.

197 sease to be immune-independent and typically oligoclonal or monoclonal.

198 his selection occurred in the presence of an oligoclonal or polyclonal T cell response using soluble

199 lantation (BMT), patients' PBMC displayed an oligoclonal or skewed T cell repertoire, low TCR excisio

200 ease, including the coronary artery, and are oligoclonal, or antigen-driven.

201 a subsets, then cloned and sequenced skewed, oligoclonal, or monoclonal peaks.

202 tive aggregates demonstrated a polyclonal or oligoclonal pattern of immunoglobulin (Ig) gene rearrang

203 Nonrandom oligoclonal patterns were found for VB6, VB14-16, VB21,

204 8(-)) are approximately 90% reduced, whereas oligoclonal plasma cell precursors are 3-fold expanded,

205 T cells in 60% of the day 14 GVHD mice were oligoclonal, pointing to a response to minor histocompat

206 We found that apoB(+) T cells build an oligoclonal population in lymph nodes of healthy mice th

207 ifically identifying a peripherally expanded oligoclonal population of activated regulatory T lymphoc

208 n in embryonic bursal precursors leads to an oligoclonal population of developing bursal follicles, s

209 ls when they were introduced as a monoclonal/oligoclonal population versus being part of a polyclonal

210 undiversified by hypermutation while later, oligoclonal populations are dominated by mutated rearran

211 the T cell repertoire with the emergence of oligoclonal populations have been described in patients

212 Oligoclonal populations occupied 71%-95% of each expande

213 Clonal or oligoclonal populations of CD8+ T cells were found to do

214 with Ag occur frequently enough to maintain oligoclonal populations of inflationary CD8(+) T cells,

215 Four infants had rash, lymphadenopathy, and oligoclonal populations of T cells in the periphery.

216 The presence of oligoclonal populations of T cells in the rejected graft

217 These expansions were composed of oligoclonal populations of T cells that had already been

218 nically resolved psoriatic lesions contained oligoclonal populations of T cells that produced IL-17A

219 Each Vbeta subset expansion was composed of oligoclonal populations of T cells.

220 ons from 8 of 10 patients with AAA contained oligoclonal populations of T cells.

221 -mutant pre-B cells resulted in long-latency oligoclonal pre-B-ALL, which demonstrates that loss of I

222 Oligoclonal predominance among tumor-infiltrating B cell

223 gesting the GCs were formed by a polyclonal (oligoclonal) process.

224 toires, consisting of absent, monoclonal, or oligoclonal profiles for the majority of Vbeta subfamili

225 in the chronic phase of infection by driving oligoclonal proliferation of infected T cells.

226 Full Treg reconstitution prevented the rapid oligoclonal proliferation that gives rise to pathogenic

227 /- 0.5 expansions/recipient) attributable to oligoclonal proliferations.

228 splenic lymphocytes from a single mouse with oligoclonal PtC-reactive cells, outgrowth of cells expre

229 ntibodies mimicked the disease pattern, with oligoclonal reactivity to a few antigens that varied bet

230 Further insight into this oligoclonal regulatory T-cell population will be fundame

231 ologous viral challenge resulted in a narrow oligoclonal repertoire with dominant clones with unpredi

232 towards specific genetic variants displayed oligoclonal repertoires, unique to each individual.

233 ell percentages were greatest in valves with oligoclonal repertoires.

234 Adventitial oligoclonal resident B cells of atherosclerotic patients

235 CR Vbeta gene usage, consistent with a local oligoclonal response.

236 via a variable HLA-C contact, generating an oligoclonal response.

237 sponsive gamma9delta2 T cells, expressing an oligoclonal set of T cell receptor (TCR) sequences which

238 urthermore, regulatory T cells showed marked oligoclonal skewing, suggesting that their peripheral ex

239 e unable to clear RV, possibly because their oligoclonal specificities may be ineffective against RV

240 identified 2 patients with multiple related (oligoclonal) subgroups of CLL cells.

241 ressed on CD4(+)CD28(null) T cells, a highly oligoclonal subset of T cells that is expanded in patien

242 fatal cases of KD to determine whether it is oligoclonal, suggesting an Ag-driven process, or polyclo

243 The activated TCR Vdelta1 cells were oligoclonal, suggesting clonal expansion, and upon repea

244 Escape mutations were oligoclonal, suggesting fitness constraints.

245 ice, STI571-treated murine CML was generally oligoclonal, suggesting that STI571 eliminated or severe

246 ertoires of iBA and BASM disease groups were oligoclonal supporting a role for an antigen-driven immu

247 id motifs, which strongly suggests Ag-driven oligoclonal T cell expansion.

248 ce showed a biased TCR repertoire indicating oligoclonal T cell expansion.

249 ileaflet aortic valves revealed considerable oligoclonal T cell expansion.

250 on, indicating the presence of monoclonal or oligoclonal T cell expansion.

251 n autoimmune muscle disease characterized by oligoclonal T cell infiltrates mediating myocytotoxicity

252 r, some of these variants were recognized by oligoclonal T cell lines from MSP2 vaccinates, indicatin

253 ls and with the expansion and persistence of oligoclonal T cell populations.

254 vealed surface expression of CD3 and CD8 and oligoclonal T cell populations.

255 Tregs to DCs and thereby inhibit spontaneous oligoclonal T cell proliferation.

256 We identified a highly oligoclonal T cell receptor repertoire, which we localiz

257 l populations further revealed highly skewed oligoclonal T cell receptor repertoires comprising exclu

258 T cells that express mainly monospecific or oligoclonal T cell receptors (TCRs).

259 ed preferential activation of T cells and an oligoclonal T cell response with skewed expansion of cer

260 the Vbeta4 family in BALB.B mice, suggesting oligoclonal T cell responses to a limited number of miHA

261 hese expanded CD4(+) T cells are composed of oligoclonal T cell subsets, suggesting their recruitment

262 To determine whether oligoclonal T cells are present in coronary arteries of

263 atients, strongly suggesting the presence of oligoclonal T cells in these infiltrates.

264 The finding of oligoclonal T cells infiltrating the skin of patients wi

265 t rejection in the atypical subjects who had oligoclonal T cells that could cause rejection.

266 nated Bacillus Calmette-Guerin infection and oligoclonal T cells with no naive markers.

267 ns or who develop rash, lymphadenopathy, and oligoclonal T cells.

268 me polyclonal in patients who presented with oligoclonal T cells.

269 erved, clearly demonstrating the presence of oligoclonal T cells.

270 proliferation, elevated IgE, and hyperactive oligoclonal T cells.

271 r-like phenotype associated with progressive oligoclonal T-cell expansion (Vbeta/HPRT ratio) and grad

272 g-acting IL-10 receptor agonist that induces oligoclonal T-cell expansion and has single-agent activi

273 in the CD8/Treg ratio and further encourages oligoclonal T-cell expansion.

274 penia within 2 to 3 weeks, accompanied by BM oligoclonal T-cell infiltration and severe marrow hypopl

275 gs of subjects with severe emphysema contain oligoclonal T-cell populations, suggesting their accumul

276 ed spectratypes, representative of clonal or oligoclonal T-cell populations, was 7.6 in MDS patients

277 R3 size distribution deviation indicative of oligoclonal T-cell proliferation was increased (44% +/-

278 Oligoclonal T-cell receptor (TCR) Vbeta families and mis

279 ck in T-cell differentiation resulting in an oligoclonal T-cell receptor repertoire and enhanced cyto

280 We studied oligoclonal T-cell receptors (TCRs) that recognize a sha

281 The residual T lymphocytes had an oligoclonal T-cell repertoire and exhibited a profound T

282 gins to populate the thymus, as evidenced by oligoclonal T-cell-receptor gene rearrangements.

283 nt versus N nucleotide addition in a classic oligoclonal, T-independent Ab response (alpha 1-->3 dext

284 er(+) cells isolated from naive mice show an oligoclonal TCR repertoire with predominant usage of the

285 In contrast, NOD-derived monoclonal/oligoclonal TCR transgenic beta cell-autoreactive T cell

286 Thus, this successful case of ACT included oligoclonal TCRs of high affinity recognizing distinct c

287 onal expansion occurred at the tumor site as oligoclonal TCRs were distinct from PBL TCRs from the sa

288 s of elite controllers frequently consist of oligoclonal to near-monoclonal clusters of intact provir

289 HIV-1 infections usually arise from mono- or oligoclonal transmission.

290 we demonstrate that CTC clusters arise from oligoclonal tumor cell groupings and not from intravascu

291 en (PyMT) gene (RCAS-PyMT) induced multiple, oligoclonal tumors within 3 weeks in infected mammary gl

292 R spectratyping of T suppressor cells showed oligoclonal usage of TCR-Vbeta families, indicating that

293 Further analysis of the oligoclonal Vbeta products showed dominant peaks in the

294 usage varied among volunteers, we identified oligoclonal Vbeta subset expansions in individual volunt

295 osal tissues of uninfected rhesus monkeys is oligoclonal, whereas the CD8(+) T cell repertoire in blo

296 d a TCR Vbeta repertoire that was strikingly oligoclonal, whereas the Vbeta repertoire of CD18(dim) T

297 ls that the DEJ CD8alphaalpha(+) T cells are oligoclonal with diverse usage of TCR variable-beta gene

298 he human Ab response to certain pathogens is oligoclonal, with preferred IgV genes being used more fr

299 quencing has confirmed that most cancers are oligoclonal, with subpopulations of neoplastic cells har

300 23F pneumococcal capsular polysaccharide is oligoclonal within the individual, with one or two parat