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1 (2) expression by their respective antisense oligodeoxyribonucleotide.
2 otin linkage and annealed to a complementary oligodeoxyribonucleotide.
3 comprised of a G-rich 18-mer triplex forming oligodeoxyribonucleotide.
4 N-acetoxy-PhIP, with a single-stranded 11mer oligodeoxyribonucleotide.
5 tive on the 5'-terminus of the support-bound oligodeoxyribonucleotide.
6 as incorporated into a short single-stranded oligodeoxyribonucleotide.
7 able to repair O6-benzylguanine in a 16-mer oligodeoxyribonucleotide.
8 er and was specifically competed by an Oct-1 oligodeoxyribonucleotide.
9 a cells to a calpain small subunit antisense oligodeoxyribonucleotide.
10 tween fivefold and 27-fold, depending on the oligodeoxyribonucleotide.
11 osphoramidite and used in the preparation of oligodeoxyribonucleotides.
12 ble and nonexchangeable protons for all four oligodeoxyribonucleotides.
13 from formal nucleotide deletion in synthetic oligodeoxyribonucleotides.
14 emolytic complement lysis than do control PS oligodeoxyribonucleotides.
15 such behavior in double- and triple-stranded oligodeoxyribonucleotides.
16 cts the ATPase activity of RecA protein with oligodeoxyribonucleotides.
17 hosphorothioate (PS) and phosphodiester (PO) oligodeoxyribonucleotides.
18 shed by pretreatment with antisense TGFbeta1 oligodeoxyribonucleotides.
19 nity for binding to native DNA and substrate oligodeoxyribonucleotides.
20 ibution, stability and radiotoxicity of 125I-oligodeoxyribonucleotides (125I-ODN) in human fibrosarco
23 solution structure of a duplex consisting of oligodeoxyribonucleotide 5'-TGATTATCTG-3' conjugated at
29 eins adjuvanted with immunostimulatory (CpG) oligodeoxyribonucleotides admixed with either Alhydrogel
30 stranded 8-bromoguanine-containing synthetic oligodeoxyribonucleotide alone and in a duplex construct
31 rotein levels by PKCdelta-specific antisense oligodeoxyribonucleotides also inhibited 15-LO expressio
32 oligomers therefore represent a new class of oligodeoxyribonucleotide analogs having phosphorus- carb
33 n excess amount of a single base substituted oligodeoxyribonucleotide and distinguishes single nucleo
34 ort the synthesis of a novel trithiol-capped oligodeoxyribonucleotide and gold nanoparticle conjugate
35 serve as lateral spacers between neighboring oligodeoxyribonucleotides and as a linker arm between th
37 ic method was developed for the synthesis of oligodeoxyribonucleotides and oligodeoxyribonucleoside m
38 nD were investigated by using JunD antisense oligodeoxyribonucleotides and transient transfection wit
39 ch as ribozymes, antisense RNA and antisense oligodeoxyribonucleotides, and for optimizing the design
40 complexes formed with 16-, 30-, and 80-base oligodeoxyribonucleotides are 3.8 +/- 0.3, 5.3 +/- 0.2,
41 this prediction showing that antisense junD oligodeoxyribonucleotides are mitogenic for differentiat
42 ion of 5-iodouridine at thymine sites of the oligodeoxyribonucleotide as an additional photoreactive
43 re introduced onto the 5'-end of a synthetic oligodeoxyribonucleotide as the last step of an automate
45 bility of RecA protein to hydrolyze UTP with oligodeoxyribonucleotides as cofactor and the ability of
46 sequence was observed using 12-mer synthetic oligodeoxyribonucleotides as substrates and as DNA seque
47 2) protein expression, mediated by antisense oligodeoxyribonucleotides (AS-ODN) specific for cPLA(2)
48 yethoxy (MOE) nucleotides into the antisense oligodeoxyribonucleotide (ASO) of the heteroduplex to al
49 ding small-molecule inhibitors and antisense oligodeoxyribonucleotides (ASON), are undergoing clinica
50 odified nucleotides were introduced into the oligodeoxyribonucleotide at the catalytic site of the he
51 Ribozyme efficacy was first assessed by an oligodeoxyribonucleotide-based assay to identify the mos
52 n of PKC epsilon protein levels by antisense oligodeoxyribonucleotides blocks MAPK activation in resp
53 d from monothiol and cyclic disulfide-capped oligodeoxyribonucleotides, but comparable hybridization
54 gth impurities was isolated from a synthetic oligodeoxyribonucleotide by PAGE and labeled with 35S.
55 arboxamide was incorporated into a series of oligodeoxyribonucleotides by solid-phase phosphoramidite
57 that gamma irradiation of a synthetic duplex oligodeoxyribonucleotide can give rise to an intrastrand
59 isense but not by sense or missense TGFbeta1 oligodeoxyribonucleotides caused essentially complete in
60 ssion of synexin was down-regulated using an oligodeoxyribonucleotide complementary to the synexin mR
63 ion at room temperature with a complementary oligodeoxyribonucleotide containing 2-fluoro-2'-deoxyino
64 hyltransferase (M.HhaI), AdoMet and a target oligodeoxyribonucleotide containing 5-fluorocytosine con
66 -l-homocysteine and a double-stranded 13-mer oligodeoxyribonucleotide containing DZCyt at the target
67 8,9-epoxide) to a specific guanine within an oligodeoxyribonucleotide containing multiple guanines wa
68 new method is reported for the synthesis of oligodeoxyribonucleotides containing 2-aminopurine resid
70 de-induced chemical ligation, four 27-member oligodeoxyribonucleotides containing a pyrophosphate int
71 poration into DNA, we chemically synthesized oligodeoxyribonucleotides containing a single dG(s) (11
72 iazoacetate exposure, and the preparation of oligodeoxyribonucleotides containing a site-specifically
73 sequence context, we used 13 different 25 bp oligodeoxyribonucleotides containing a unique hypoxanthi
77 for antisense therapeutics, we have prepared oligodeoxyribonucleotides containing more than 200 diffe
78 examined whether human AGT could react with oligodeoxyribonucleotides containing multiple b(6)G resi
79 both ATL proteins bind with high affinity to oligodeoxyribonucleotides containing O(6)-alkylguanines
80 as also observed with single-stranded 16-mer oligodeoxyribonucleotides containing O(6)-methylguanine,
83 In order to trap a covalent AGT-DNA complex, oligodeoxyribonucleotides containing the novel nucleosid
87 between HhaI methyltransferase (M.HhaI) and oligodeoxyribonucleotides containing ZCyt at the target
93 tudies are reported for two nine-residue DNA oligodeoxyribonucleotides, d(CATGGGTAC).d(GTACNCATG) (1)
94 stability and conformation of the antisense oligodeoxyribonucleotides, d[CGCGTT x TTGCGC] [x = phosp
96 ically modified and stereochemically defined oligodeoxyribonucleotides derived from the covalent reac
98 nor hearts with a phosphorothioate antisense oligodeoxyribonucleotide directed against Egr-1 before o
99 onor lungs with a phosphorothioate antisense oligodeoxyribonucleotide directed against the Egr-1 tran
100 Transfecting cortical neurons with antisense oligodeoxyribonucleotides directed against NP1 mRNA (NP1
103 the interactions of NF-kappaB proteins with oligodeoxyribonucleotide duplexes containing kappaB site
104 ame complex was also shown to bind synthetic oligodeoxyribonucleotide duplexes containing the nonnatu
105 stics of bends in site-specifically modified oligodeoxyribonucleotide duplexes induced by single (+)-
106 scarbamylase (OTC) by recursive PCR using 18 oligodeoxyribonucleotides, each 70-80 nucleotides in len
107 de and was attached to the 5'-terminus of an oligodeoxyribonucleotide following a reverse coupling pr
108 interventional phase III trials of antisense oligodeoxyribonucleotides for a cancer indication will b
109 The major hurdle associated with utilizing oligodeoxyribonucleotides for therapeutic purposes is th
111 thesis and triplex stabilizing properties of oligodeoxyribonucleotides functionalized at the 5'- and/
112 cence studies using 2-aminopurine-containing oligodeoxyribonucleotides further revealed the sequentia
115 cytosine in G-C-G-C sites in double-stranded oligodeoxyribonucleotides had a similar effect on methyl
116 e recombinant human MPG protein from a 39 bp oligodeoxyribonucleotide harboring a unique hypoxanthine
122 ditions, only the perfectly sequence-matched oligodeoxyribonucleotide hybridized to each probe, while
123 etric data indicate that the single-stranded oligodeoxyribonucleotides hydrate very similarly to dupl
124 potent as inhibitors of DNA methylation than oligodeoxyribonucleotides identical in sequence containi
125 en antigen, conjugated to a phosphorothioate oligodeoxyribonucleotide immunostimulatory sequence of D
128 STAT1 and STAT3 transcription factor decoys oligodeoxyribonucleotides into PC12 cells, nicotine indu
129 DNA methyltransferase covalently bound to an oligodeoxyribonucleotide is not efficiently excised by u
131 s on spectral bands in these single-stranded oligodeoxyribonucleotides is markedly different from suc
134 DNA and related synthetic immunostimulatory oligodeoxyribonucleotides (ISS-ODN) stimulate innate imm
136 g., CD40L) and TLRs (e.g., immunostimulatory oligodeoxyribonucleotides (ISS-ODNs)) is crucial for max
138 e with 1,2-dibromoethane and single-stranded oligodeoxyribonucleotides led to the formation of covale
139 yzed in reactions in which the cofactors are oligodeoxyribonucleotides less than approximately 50 nt
142 id duplex formed by a methylphosphonate (MP) oligodeoxyribonucleotide (MPO) and its target oligoribon
144 f novel nucleic acid analogs, alpha-anomeric oligodeoxyribonucleotide N3'-->P5' phosphoramidates, are
145 dation of 1-methyladenine in poly(dA), short oligodeoxyribonucleotides, nucleotides, and nucleoside t
147 e marrow and treated with NF-kappaB-specific oligodeoxyribonucleotide (ODN) in vitro (NF-kappaB ODN D
148 ng three different adjuvants showed that CpG oligodeoxyribonucleotide (ODN) induces very low levels o
149 with polyethylene glycol was used to improve oligodeoxyribonucleotide (ODN) loading, stability of the
150 ived a daily injection of TNFalpha antisense oligodeoxyribonucleotide (ODN) or control on days 1 thro
151 esigned and tested prototype NIR fluorescent oligodeoxyribonucleotide (ODN) reporters that can sense
153 though iPLA(2)beta or cPLA(2)alpha antisense oligodeoxyribonucleotide (ODN)-treated monocytes display
154 e designed a new class of modified antisense oligodeoxyribonucleotides (ODN) consisting of a central
155 ir maturation was arrested by treatment with oligodeoxyribonucleotides (ODN) specifically against nuc
156 dual PKC isoforms, we chose to use antisense oligodeoxyribonucleotides (ODN) to specifically reduce P
158 nthetic polyamines on the conformation of an oligodeoxyribonucleotide (ODN1) harboring the estrogen r
159 hosphodiester (PO) and phosphorothioate (PS) oligodeoxyribonucleotides (ODNs) (21-mer) targeted to th
160 in 15-LO expression, we generated antisense oligodeoxyribonucleotides (ODNs) against Tyk2 and Jak2.
163 n containing a tryptophan (Trp) reporter and oligodeoxyribonucleotides (ODNs) containing a fluorescen
164 ch can be blocked by double-stranded "decoy" oligodeoxyribonucleotides (ODNs) containing binding site
165 we have identified partial phosphorothioate oligodeoxyribonucleotides (ODNs) containing C-5 propynyl
167 Sequencing reactions were conducted with oligodeoxyribonucleotides (ODNs) containing d(Me)isoC an
168 port, for the first time, the preparation of oligodeoxyribonucleotides (ODNs) containing individual d
169 cess for the first time to a wide variety of oligodeoxyribonucleotides (ODNs) containing O6-alkylguan
171 ense, but not sense, nonsense, or scrambled, oligodeoxyribonucleotides (ODNs) decreased DNA synthesis
174 of transduction with high-affinity antisense oligodeoxyribonucleotides (ODNs) designed to target the
175 highest binding affinities, while pyrimidine oligodeoxyribonucleotides (ODNs) did not show appreciabl
176 ted, solid-phase synthesis of mixed backbone oligodeoxyribonucleotides (ODNs) having 1,2,3-triazolylp
178 ofuranosyl nucleosides)] into antisense (AS) oligodeoxyribonucleotides (ODNs) should greatly improve
179 cultures treated with HSV DNA or HSV-derived oligodeoxyribonucleotides (ODNs) showed strong prolifera
180 e we report the synthesis of phosphotriester oligodeoxyribonucleotides (ODNs) that are stable to the
182 the native, endogenous mRNA is probed using oligodeoxyribonucleotides (ODNs) to identify RNase H-acc
183 lently linked to the 5' or 3' end of several oligodeoxyribonucleotides (ODNs) totally complementary o
184 or the highly efficient chemical ligation of oligodeoxyribonucleotides (ODNs) using cyanogen bromide
189 addition of micromolar concentrations of an oligodeoxyribonucleotide of arbitrary sequence to the tu
190 he target strands compared with an all 3'-5'-oligodeoxyribonucleotide of the same sequence and length
192 ated synthesis on 0.2-1.0 micromol scales of oligodeoxyribonucleotides, of length 6-20 bases, contain
194 RT-PCR using human cerebral cortex mRNA and oligodeoxyribonucleotide (oligo) primers derived from th
195 Following Edman degradation, three 17-mer oligodeoxyribonucleotide (oligo) probes corresponding to
197 that the nuclear factor binding to the FP160 oligodeoxyribonucleotide (oligo) was competed by oligos
199 edure for generating long primers from short oligodeoxyribonucleotides (oligos) to incorporate DNA cr
201 ichia coli RNA polymerase of single-stranded oligodeoxyribonucleotides (oligos) with the sequence of
202 HER2/neu-specific phosphorothioate antisense oligodeoxyribonucleotides on HER2/neu expression, tumor
203 when incubated with a mixture of two 16-mer oligodeoxyribonucleotides, one containing O6-benzylguani
204 ynthesis and biophysical characterization of oligodeoxyribonucleotides (ONs) modified with 2'-amino-a
206 dites were synthesized and incorporated into oligodeoxyribonucleotides (ONs), which were then charact
208 ansferases to generate unique DPC adducts in oligodeoxyribonucleotides or plasmids to monitor both in
209 biological origin, such as oligopeptides and oligodeoxyribonucleotides, or with intact native protein
210 Dicer-substrate siRNAs equipped with CpG oligodeoxyribonucleotides overcome the major hurdle in c
211 Homopurine (AG) and homopyrimidine (CT) oligodeoxyribonucleotides predicted to form triple-helic
212 ted from an 18-nucleotide (nt) oligoribo- or oligodeoxyribonucleotide primer complementary to the pri
213 (KF) as a model proofreading polymerase and oligodeoxyribonucleotide primer/templates as model DNA s
214 microorganisms in clinical specimens employ oligodeoxyribonucleotide primers and probes for specific
216 the synthesis of a radioactive, photolabile oligodeoxyribonucleotide probe and its exploitation in i
217 the synthesis of a radioactive, photolabile oligodeoxyribonucleotide probe and its exploitation in i
218 te constants and thermodynamic affinities of oligodeoxyribonucleotide probes binding to simple synthe
221 yuridine in both single- and double-stranded oligodeoxyribonucleotides provided much better substrate
222 ing gene-specific antisense phosphorothioate oligodeoxyribonucleotides (PS-ODNs) by the addition of 5
223 specific antisense phosphorothioate-modified oligodeoxyribonucleotides (PS-ODNs) targeting different
224 dicals, G(-H)* in single- or double-stranded oligodeoxyribonucleotides (rate constant of 4.7 +/- 1.0
225 '-5'-ribonucleoside incorporation into 3'-5'-oligodeoxyribonucleotides reduces binding to the target
226 e preparation of phosphorothioate-containing oligodeoxyribonucleotides rely on the reaction of phosph
227 Analysis of MPG protein binding to the 39 bp oligodeoxyribonucleotide revealed that the apparent diss
228 We have developed a system to carry out oligodeoxyribonucleotide-RNA and ribozyme-RNA binding ex
230 g site incorporated within a double-stranded oligodeoxyribonucleotide sequence even in the presence o
231 r, the nature of the protein domain, and the oligodeoxyribonucleotide sequences flanking the platinat
233 th, double-stranded, hypoxanthine-containing oligodeoxyribonucleotides show that the footprinted regi
234 re, by transfecting monocytes with the decoy oligodeoxyribonucleotides specific for Egr-1 and CREB, w
235 ecific molecularly imprinted single-stranded oligodeoxyribonucleotide (ss-ODN) biosensor was fabricat
236 talytic turnover using a hydrolyzable duplex oligodeoxyribonucleotide substrate containing a uracil:2
238 , together with the preparation of authentic oligodeoxyribonucleotide substrates housing these two le
239 otides of single-stranded or double-stranded oligodeoxyribonucleotide substrates led to complete inhi
241 talyzed reaction with small, single-stranded oligodeoxyribonucleotide substrates under single-turnove
243 active group conjugated to a triplex forming oligodeoxyribonucleotide (TFO) that binds in the major g
244 e within a mammalian gene, a triplex-forming oligodeoxyribonucleotide (TFO) that binds with high affi
246 To explore the ability of triplex-forming oligodeoxyribonucleotides (TFOs) to inhibit genes respon
247 substituent, adamantylcarbamoyl, yielded an oligodeoxyribonucleotide that dissociated with a T m of
249 backbone on the reactions of cisplatin with oligodeoxyribonucleotides that lack or contain a GTG seq
250 that endo VIII removes from double-stranded oligodeoxyribonucleotides the stable oxidative products
251 c AP site-lysine-cross-linked peptide and an oligodeoxyribonucleotide, the method was used to determi
252 sequence d(TG)n than with any homopolymeric oligodeoxyribonucleotide; thus, it shows a strong sequen
253 tracerebroventricular injection of antisense oligodeoxyribonucleotide to Kv1.1 reduces expression of
254 th specific antibodies showed that antisense oligodeoxyribonucleotide to Kv1.4 microinjected intraven
256 e, when M21 cells transfected with antisense oligodeoxyribonucleotide to the hnRNP L RNA-binding site
257 chemistry with subunit-specific 35S-labelled oligodeoxyribonucleotides to examine these mRNAs in adul
260 duplex DNA sequence recognized by a G/T-rich oligodeoxyribonucleotide under conditions favoring purin
261 accuracy was adequate to verify sequences of oligodeoxyribonucleotides up to 9500-Da molecular mass.
262 mino groups can be coupled to thiol-modified oligodeoxyribonucleotides using a heterobifunctional cro
263 e of the phosphodiester linkage by NaOH, the oligodeoxyribonucleotide was attached to streptavidin-co
266 ed phosphonoacetate and thiophosphonoacetate oligodeoxyribonucleotides were chemically synthesized an
267 thods for controlling the surface density of oligodeoxyribonucleotides were explored: in the first, b
269 ected with 9-fluorenylmethyloxycarbonyl, and oligodeoxyribonucleotides were synthesized on controlled
273 e this process, pDCs were activated with CpG oligodeoxyribonucleotides, which stimulated the secretio
275 nting experiments with the MPG protein on an oligodeoxyribonucleotide with a unique hypoxanthine at a
277 utarate Fe(II) dioxygenase activity using an oligodeoxyribonucleotide with a unique modification show
283 ome commonly used fluorophores conjugated to oligodeoxyribonucleotides with different primary and sec
284 bles successful incorporation of SP TpT into oligodeoxyribonucleotides with high efficiency via stand
285 mide moiety, was incorporated into synthetic oligodeoxyribonucleotides with the use of a benzoyl prot
286 -benzyl or -methyl groups when present in an oligodeoxyribonucleotide without altering the reaction w
287 for cleavage and deprotection of dye-labeled oligodeoxyribonucleotides without any degradation or mod